metabolism

Summary

Summary: The sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosysthesis) and catabolism; the buildup and breakdown of molecules for utilization by the body.

Top Publications

  1. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
  2. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
  3. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
  4. ncbi Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
  5. ncbi Network biology: understanding the cell's functional organization
    Albert Laszlo Barabasi
    Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Nat Rev Genet 5:101-13. 2004
  6. ncbi The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    M Hucka
    Control and Dynamical Systems, MC 107 81, California Institute of Technology, Pasadena, CA 91125, USA
    Bioinformatics 19:524-31. 2003
  7. ncbi Hierarchical organization of modularity in metabolic networks
    E Ravasz
    Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 297:1551-5. 2002
  8. pmc The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    Charles E Massie
    CRUK Cambridge Research Institute, Cambridge, UK
    EMBO J 30:2719-33. 2011
  9. pmc Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood
    Elinor L Sullivan
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroendocrinology 93:1-8. 2011
  10. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005

Research Grants

  1. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen Beverley; Fiscal Year: 2009
  2. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  4. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
  5. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 2000
  6. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 2002
  7. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 2001
  8. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 1999
  9. Administrative Resource
    Reese T Jones; Fiscal Year: 2011
  10. ALTERED METABOLISM AND CARCINOGENESIS BY DES
    CORAL LAMARTINIERE; Fiscal Year: 1990

Detail Information

Publications293 found, 100 shown here

  1. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
    ..The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes...
  2. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
    ..Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions...
  3. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
    ..More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks...
  4. ncbi Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
    The alterations in myocardial energy substrate metabolism that occur in heart failure, and the causes and consequences of these abnormalities, are poorly understood...
  5. ncbi Network biology: understanding the cell's functional organization
    Albert Laszlo Barabasi
    Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Nat Rev Genet 5:101-13. 2004
  6. ncbi The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    M Hucka
    Control and Dynamical Systems, MC 107 81, California Institute of Technology, Pasadena, CA 91125, USA
    Bioinformatics 19:524-31. 2003
    ..Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively...
  7. ncbi Hierarchical organization of modularity in metabolic networks
    E Ravasz
    Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 297:1551-5. 2002
    ..Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization...
  8. pmc The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    Charles E Massie
    CRUK Cambridge Research Institute, Cambridge, UK
    EMBO J 30:2719-33. 2011
    ..cancer and regulates cancer cell growth via its unexpected role as a hormone-dependent modulator of anabolic metabolism. In conclusion, it is possible to progress from transcriptional studies to a promising therapeutic target by ..
  9. pmc Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood
    Elinor L Sullivan
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroendocrinology 93:1-8. 2011
    ..The perinatal environment plays an important role in programming many aspects of physiology and behavior including metabolism, body weight set point, energy balance regulation and predisposition to mental health-related disorders such as ..
  10. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005
    ..model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as the cell cycle...
  11. ncbi At the crossroad between immunity and metabolism: focus on leptin
    Javier Conde
    Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammation Disease, Building C, Level 2, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Calle Choupana s n, Santiago de Compostela, 15706, Spain
    Expert Rev Clin Immunol 6:801-8. 2010
    ..most important adipokines secreted by fat cells, with a variety of physiological roles related to the control of metabolism, energy homeostasis and inflammatory response...
  12. pmc A role for gene duplication and natural variation of gene expression in the evolution of metabolism
    Daniel J Kliebenstein
    Department of Plant Sciences, University of California Davis, Davis, California, United States of America
    PLoS ONE 3:e1838. 2008
    ..Finally, the ability of gene duplicates to diverge may be limited by their biological function...
  13. doi Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences
    Nicholas A Burd
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster Univ, 1280 Main St, West Hamilton, ON, Canada L8S 4K1
    J Appl Physiol (1985) 106:1692-701. 2009
    ..Furthermore, we examine the underlying anabolic signaling pathways and molecules that regulate these processes...
  14. ncbi The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Biochem 43:732-44. 2010
    ..Its metabolism methylates homocysteine to methionine, also producing N,N-dimethylglycine...
  15. pmc Expansion of the BioCyc collection of pathway/genome databases to 160 genomes
    Peter D Karp
    Bioinformatics Research Group, SRI International EK207, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Nucleic Acids Res 33:6083-9. 2005
    ..Only by harnessing the expertise of many scientists we can hope to produce biological databases, which accurately reflect the depth and breadth of knowledge that the biomedical research community is producing...
  16. pmc Coral larvae under ocean acidification: survival, metabolism, and metamorphosis
    Masako Nakamura
    Sesoko Station, Tropical Biosphere Research Center, University of the Ryukyus, Okinawa, Japan
    PLoS ONE 6:e14521. 2011
    ..These results imply that acidified seawater impacts larval physiology, suggesting that suppressed metabolism and metamorphosis may alter the dispersal potential of larvae and subsequently reduce the resilience of coral ..
  17. ncbi FGFs and metabolism
    Alexei Kharitonenkov
    Eli Lilly and Company, Lilly Research Laboratories, Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Curr Opin Pharmacol 9:805-10. 2009
    ..morphogenesis, angiogenesis, hematopoiesis, and survival, this decade provided clues on FGF roles in metabolism. In particular, 'hormone-like' FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, ..
  18. pmc The KEGG databases at GenomeNet
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 30:42-6. 2002
    ..The KEGG databases are updated daily and made freely available (http://www.genome.ad.jp/kegg/)...
  19. ncbi Epigenetics and metabolism in 2011: Epigenetics, the life-course and metabolic disease
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Rev Endocrinol 8:74-6. 2012
    ..Data published in 2011 suggest that epigenetic analysis could potentially have utility as a marker of early metabolic pathology and might enable early life prophylaxis...
  20. ncbi A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum
    Uly Nasution
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Metab Eng 10:10-23. 2008
    The relation between central metabolism and the penicillin biosynthesis pathway in Penicillium chrysogenum was studied by manipulating the steady-state flux in both pathways...
  21. ncbi Metabolite profiling for plant functional genomics
    O Fiehn
    Max Planck Institute of Molecular Plant Physiology, 14424 Potsdam, Germany
    Nat Biotechnol 18:1157-61. 2000
    ..These results demonstrate the use of metabolite profiling as a tool to significantly extend and enhance the power of existing functional genomics approaches...
  22. doi Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)
    Ravi Kumar Sangeetha
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, CSIR, Mysore, 570 020, India
    Mol Cell Biochem 333:299-310. 2010
    This study reports bioavailability and metabolism of fucoxanthin (FUCO) from brown algae Padina tetrastromatica in rats. Rats were divided into two groups (n = 25/group)...
  23. ncbi Internal desynchronization in a model of night-work by forced activity in rats
    R Salgado-Delgado
    Departamento de Anatomia, Facultad de Medicina, Edificio B 4 Piso, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
    Neuroscience 154:922-31. 2008
    ..The present data suggest that in the night worker the combination of work and eating during working hours may be the cause of internal desynchronization...
  24. ncbi Diet, metabolism and lifespan in Drosophila
    Matthew D W Piper
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Gerontol 40:857-62. 2005
    ..Current data indicate lifespan-extension by DR is likely to involve both enhancement of various defense and detoxification mechanisms and a complex range of metabolic alterations that make energy available for these processes...
  25. ncbi From measurements of metabolites to metabolomics: an 'on the fly' perspective illustrated by recent studies of carbon-nitrogen interactions
    Mark Stitt
    Departments of Metabolic Networks and Molecular Physiology, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Curr Opin Biotechnol 14:136-44. 2003
    ..A major future challenge concerns the integration of the information gained from metabolite profiling into an accessible body of knowledge...
  26. pmc Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008
    ..To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial...
  27. pmc Choline metabolism and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 22:2045-52. 2008
    Choline is an essential nutrient required for methyl group metabolism, but its role in carcinogenesis and tumor progression is not well understood...
  28. pmc Dynamic flux balance analysis of diauxic growth in Escherichia coli
    Radhakrishnan Mahadevan
    Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716 USA
    Biophys J 83:1331-40. 2002
    ..Therefore, dynamic FBA provides a framework for analyzing the transience of metabolism due to metabolic reprogramming and for obtaining insights for the design of metabolic networks.
  29. pmc The hypocretins as sensors for metabolism and arousal
    Antoine Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5742, USA
    J Physiol 587:33-40. 2009
    ..Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions...
  30. ncbi Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response
    Valerio Gozzoli
    Surgical Intensive Care Division, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Intensive Care Med 30:401-7. 2004
    ..We investigated the metabolic, hemodynamic, and inflammatory responses of pharmacological and physical therapies aimed at reducing body temperature in febrile critically ill patients...
  31. pmc Metabolism strikes back: metabolic flux regulates cell signaling
    Christian M Metallo
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 24:2717-22. 2010
    ..This mechanism ensures that cells do not engage in anabolic metabolism when nutrients are limiting, and highlights how substrate availability for protein modifications can modulate ..
  32. ncbi Regulation of growth and metabolism by imprinted genes
    F M Smith
    Centre for Regenerative Medicine and Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath, UK
    Cytogenet Genome Res 113:279-91. 2006
    ..to influence energy homeostasis and some, including Igf2 and Grb10, may coordinate growth with glucose-regulated metabolism. Since perturbation of fetal growth can be correlated with metabolic disorders in adulthood these imprinted ..
  33. pmc From sirtuin biology to human diseases: an update
    Carlos Sebastian
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 287:42444-52. 2012
    ..In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas...
  34. doi NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology
    Muireann Coen
    Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK
    Chem Res Toxicol 21:9-27. 2008
    ..The use of biological fluids as a source of whole organism metabolic information enhances the use of this approach in minimally invasive longitudinal studies...
  35. ncbi 13C metabolic flux analysis
    W Wiechert
    Department of Simulation, IMR, University of Siegen, Paul Bonatz Strasse 9 11, D 57068 Siegen, Germany
    Metab Eng 3:195-206. 2001
    ..It allows the detailed quantification of all intracellular fluxes in the central metabolism of a microorganism...
  36. pmc Computational prediction of human metabolic pathways from the complete human genome
    Pedro Romero
    Bioinformatics Research Group, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Genome Biol 6:R2. 2005
    ..Pathway assignments place genes in their larger biological context, and are a necessary first step toward quantitative modeling of metabolism.
  37. ncbi Genome-scale microbial in silico models: the constraints-based approach
    Nathan D Price
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 2093 0412, USA
    Trends Biotechnol 21:162-9. 2003
    ..These results are useful as a basis for iterative model building and for several practical applications...
  38. ncbi The fourth dimension of life: fractal geometry and allometric scaling of organisms
    G B West
    Theoretical Division, MS B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 284:1677-9. 1999
    ..These design principles are independent of detailed dynamics and explicit models and should apply to virtually all organisms...
  39. ncbi Bow ties, metabolism and disease
    Marie Csete
    Emory Anesthiology Research Labs, 1462 Clifton Rd NE, Room 420, Atlanta GA 30322, USA
    Trends Biotechnol 22:446-50. 2004
    ..Large-scale organizational frameworks such as the bow tie are necessary starting points for higher-resolution modeling of complex biologic processes..
  40. ncbi Evidence for a proximate influence of winter temperature on metabolism in passerine birds
    D L Swanson
    Department of Biology, University of South Dakota, Vermillion, SD 57069 2390, USA
    Physiol Biochem Zool 72:566-75. 1999
    ..Least-squares regression revealed significant negative relationships for normalized basal and summit metabolism against mean winter temperature for all species pooled (R2=0.62 to 0.69, P</=0.001)...
  41. pmc Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
    David Leitsch
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Antimicrob Chemother 66:1756-65. 2011
    ..Resistance to metronidazole has been associated with down-regulation of PFOR and Fd. The aim of this study was to determine whether the PFOR/Fd couple is the only pathway involved in metronidazole activation in Giardia...
  42. doi Bone and metabolism: a complex crosstalk
    Liesbet Lieben
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Horm Res 71:134-8. 2009
    Until recently, communication from metabolism to bone was considered purely unidirectional, involving complex interactions among an adipocyte-derived factor (leptin), the sympathetic nervous system and neuropeptides...
  43. doi PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism
    Beatrice Desvergne
    Center of Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Cell Metab 7:467-9. 2008
    ..In two studies by Kang et al. (2008) and Odegaard et al. (2008) in this issue of Cell Metabolism, we learn that alternative activation (M2a) of resident macrophages in liver and adipose tissue depends highly ..
  44. ncbi H2S induced hypometabolism in mice is missing in sedated sheep
    Philippe Haouzi
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States
    Respir Physiol Neurobiol 160:109-15. 2008
    ..We measured metabolism in conscious mice (24 g) exposed to H(2)S (60 ppm) at an ambient temperature of 23-24 degrees C...
  45. doi Diabetes and protein metabolism
    Niels Møller
    Medical Department M, Aarhus University Hospital, Medical Research Laboratories, Aarhus C 8000, Denmark
    Diabetes 57:3-4. 2008
  46. ncbi Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, Purdue UAB Botanicals Center for Age Related Disease, UAB Center for Nutrient Gene Interaction in Cancer Prevention, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Pharm 4:846-64. 2007
    ..behavior of these compounds following oral ingestion is needed as well as their absorption, distribution, metabolism, and excretion (ADME)...
  47. ncbi Organizational invariance and metabolic closure: analysis in terms of (M,R) systems
    Juan Carlos Letelier
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    J Theor Biol 238:949-61. 2006
    ..formulation of (M,R) systems in terms of mappings and sets of mappings, which is grounded in the metaphor of metabolism as a mathematical mapping...
  48. ncbi Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression
    Weiling Zhao
    Department of Radiation Oncology, Brain Tumor Center of Wake Forest University, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Clin Cancer Res 12:3823-30. 2006
    ..As such, the aim of the present study was to identify candidate genes involved in the development of radiation injury in the murine kidney and brain using microarray analysis...
  49. pmc Hypothalamic sites of leptin action linking metabolism and reproduction
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9077, USA
    Neuroendocrinology 93:9-18. 2011
    ..In this review, we discuss the recent advances in the field focused on the identification of potential site(s) or specific neuronal populations involved in leptin's effects in the neuroendocrine reproductive axis...
  50. doi Transplantation of adipose tissue and stem cells: role in metabolism and disease
    Thien T Tran
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Nat Rev Endocrinol 6:195-213. 2010
    ..metabolic effects, subcutaneous white adipose tissue and brown adipose tissue have the potential to benefit metabolism by improving glucose homeostasis and increasing energy consumption...
  51. doi The circadian clock and metabolism
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Clin Sci (Lond) 120:65-72. 2011
    ..and physiological functions in addition to the expression and/or activity of enzymes and hormones involved in metabolism. In turn, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism...
  52. ncbi A salvage pathway for phytol metabolism in Arabidopsis
    Till Ischebeck
    Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    J Biol Chem 281:2470-7. 2006
    ..Thus, Arabidopsis contains a distinct enzymatic machinery for redirecting free phytol released from chlorophyll degradation into chloroplast lipid metabolism.
  53. ncbi Adenine nucleotide metabolism in human blood--important roles for leukocytes and erythrocytes
    S Heptinstall
    Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, University of Nottingham, UK
    J Thromb Haemost 3:2331-9. 2005
    ..Rapid metabolism of ADP and ATP by endothelial cells is important in protecting platelets from their effects...
  54. pmc HMDB: the Human Metabolome Database
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 35:D521-6. 2007
    ..HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world...
  55. ncbi Effects of olanzapine and haloperidol on the metabolic status of healthy men
    Solrun Vidarsdottir
    Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 95:118-25. 2010
    ..The aim of this study was to determine the effect of short-term olanzapine (atypical antipsychotic drug) and haloperidol (conventional antipsychotic drug) treatment on glucose and lipid metabolism.
  56. ncbi Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    John C Lindon
    Biological Chemistry, Biomedical Sciences, Division, Faculty of Medicine, Imperial College London, UK
    Biomarkers 9:1-31. 2004
    ..review, metabonomics, a combination of data-rich analytical chemical measurements and chemometrics for profiling metabolism in complex systems, is described and its applications are reviewed...
  57. ncbi Chemometrics in metabonomics
    Johan Trygg
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Sweden
    J Proteome Res 6:469-79. 2007
    ..This is illustrated by examples from the literature...
  58. ncbi Transcriptional regulation of metabolism
    Beatrice Desvergne
    Center for Integrative Genomics, National Centre of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Physiol Rev 86:465-514. 2006
    Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made towards elucidating the mechanisms controlling the major regulatory pathways are now being rewarded...
  59. doi Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
    Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science...
  60. doi Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation
    Christoph Handschin
    Biozentrum, University of Basel, Basel and Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Clin Exp Pharmacol Physiol 36:1139-43. 2009
    1. In higher eukaryotes, metabolism and immunity are tightly coupled...
  61. ncbi In vitro fertilization improves childhood growth and metabolism
    Harriet L Miles
    The National Research Centre for Growth and Development and Liggins Institute, University of Auckland, Auckland 1010, New Zealand
    J Clin Endocrinol Metab 92:3441-5. 2007
    ..There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase in rare imprinted gene disorders such as Beckwith-Wiedemann syndrome has been reported...
  62. ncbi Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats
    Anthony Fardet
    Unite de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Recherche de Clermont Ferrand Theix, F 63122 St Genes Champanelle, France
    J Nutr 138:1282-7. 2008
    ..The latter can be characterized by a metabolomics approach. In this work, we compared the metabolism of lignins to that of the structurally related ferulic acid (FA) and sinapic acid (SA)...
  63. pmc A minimal model of metabolism-based chemotaxis
    Matthew D Egbert
    Centre for Computational Neuroscience and Robotics, University of Sussex, Brighton, United Kingdom
    PLoS Comput Biol 6:e1001004. 2010
    Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption...
  64. ncbi Mitotic activity of rat muscle satellite cells in response to serum stimulation: relation with cellular metabolism
    Aude E Barani
    Laboratoire de Physiologie, Groupe Physiologie et Physiopathologie de l Exercice et du Handicap, Groupement d Intérêt Public Exercice Sport Santé, Faculte de Medecine, 15 rue Ambroise Paré, 42023 Saint Etienne, France
    Exp Cell Res 283:196-205. 2003
    ..of energetic and proteolytic metabolisms, including an increase in the relative contribution of glycolytic metabolism for energy production, an increase in proteasome and matrix metalloproteinases 2 and 9 activities, and a ..
  65. ncbi Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms
    Hongwu Ma
    GBF German Research Center for Biotechnology, Microbial Systems, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Bioinformatics 19:270-7. 2003
    ..These networks are often very large and complex. To properly understand and analyze the global properties of metabolic networks, methods for rationally representing and quantitatively analyzing their structure are needed...
  66. ncbi Altered body composition and metabolism in the male offspring of high fat-fed rats
    Alexandra J Buckley
    School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
    Metabolism 54:500-7. 2005
    ..fat can modify the programming of an offspring's glucose tolerance, insulin sensitivity, body composition, lipid metabolism, and insulin signaling...
  67. doi Conserved metabolic regulatory functions of sirtuins
    Bjoern Schwer
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Cell Metab 7:104-12. 2008
    ..The earliest function of sirtuins therefore may have been regulation of cellular metabolism in response to nutrient availability...
  68. pmc MicroRNAs in metabolism and metabolic diseases
    V Rottiers
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Cold Spring Harb Symp Quant Biol 76:225-33. 2011
    ..NAD(+)-dependent sirtuin SIRT6, and the insulin signaling intermediate IRS2, key regulators of glucose and lipid metabolism. These results have revealed a highly integrated microRNA (miRNA)-host gene circuit governing cholesterol/lipid ..
  69. doi Intracellular mechanisms of metabolism regulation: the role of signaling via the mammalian target of rapamycin pathway and other routes
    Vincenzo Flati
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Am J Cardiol 101:16E-21E. 2008
    ..Our observations provide molecular evidence that supports the use of anabolic nutrients such as AAs, together with standard therapies, to overcome insulin resistance syndrome...
  70. pmc Integrating cellular metabolism into a multiscale whole-body model
    Markus Krauss
    Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany
    PLoS Comput Biol 8:e1002750. 2012
    Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology...
  71. ncbi Online monitoring of cellular metabolism in the MCF-7 carcinoma cell line treated with phytoestrogen extracts
    S Abarzua
    Department Biological Sciences, University of Rostock, Institute of Biological Sciences, Rostock, Germany
    Anticancer Res 30:1587-92. 2010
    ..The aim of this study was to isolate phytoestrogens from the flax root of Linum usitatissimum and to test their effect on cellular metabolism in the human mammalian carcinoma cell line MCF-7 using the Bionas 2500 analysis system.
  72. doi Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function
    Mads Halbirk
    Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark
    Am J Physiol Heart Circ Physiol 299:H1220-5. 2010
    ..In conclusion, acipimox caused minor changes in whole body metabolism and decreased the FFA supply, but a long-term reduction in circulating FFAs with acipimox did not change ..
  73. pmc A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor
    Daniel Rozas
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    PLoS ONE 7:e31760. 2012
    ..Therefore, this two-component system in S. coelicolor seems to influence various processes characterised by the transition from primary to secondary metabolism, as determined by proteomic and transcriptomic analyses.
  74. ncbi Effects of short-term oral salbutamol administration on exercise endurance and metabolism
    K Collomp
    Laboratoire National de Dépistage du Dopage, Chatenay Malabry, France
    J Appl Physiol (1985) 89:430-6. 2000
    ....
  75. pmc CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Sci Signal 2:re3. 2009
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development...
  76. ncbi Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients
    B J Bequette
    Department of Animal and Avian Sciences, University of Maryland, College Park, 20742, USA
    J Anim Sci 84:E50-9. 2006
    ..This paper highlights aspects of animal nutrition and metabolism in which [U-13C] substrates and MID can be applied to investigations of amino acid, carbohydrate, and fat ..
  77. doi Effects of intermittent hydrostatic pressure and BMP-2 on osteoarthritic human chondrocyte metabolism in vitro
    R L Smith
    Bone and Joint RR and D Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Orthop Res 29:361-8. 2011
    ....
  78. doi Nutrition and metabolism: non-alcoholic fatty liver disease - pathogenesis, cardiovascular risk and therapy
    Gerald F Watts
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Lipidol 19:92-4. 2008
  79. ncbi Regulatory roles of leptin in reproduction and metabolism: a comparative review
    D A Zieba
    Animal Reproduction Laboratory, Texas A and M University Agricultural Research Station, 3507 Hwy 59E, Beeville, TX 78102, USA
    Domest Anim Endocrinol 29:166-85. 2005
    ..Future therapeutic uses for recombinant leptin that exploit states of nutritional hypersensitization, and identification of genetic markers for genotypic variation in leptin resistance, are currently under investigation...
  80. ncbi Evolution of the protein repertoire
    Cyrus Chothia
    Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 300:1701-3. 2003
    ..Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes...
  81. ncbi Sir2 links chromatin silencing, metabolism, and aging
    L Guarente
    Department of Biology, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts 02139 USA
    Genes Dev 14:1021-6. 2000
  82. ncbi Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
    Fu Yang
    Department of Medical Genetics, Second Military Medical University, Shanghai, PR China
    J Hepatol 48:12-9. 2008
    ....
  83. ncbi In silico techniques for the study and prediction of xenobiotic metabolism: a review
    S A Kulkarni
    Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
    Xenobiotica 35:955-73. 2005
    Knowledge about metabolism is very important to understand the health risks posed by chemicals...
  84. ncbi Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery
    Mark P Styczynski
    Department of Chemical Engineering, Massachusetts Institute of Technology, Room 56 469c, Cambridge, Massachusetts 02139, USA
    Anal Chem 79:966-73. 2007
    ..By systematically cataloguing conserved metabolite peaks prior to data analysis methods, our approach broadens the scope of metabolomics and facilitates biomarker discovery...
  85. ncbi Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
    Marc Emmanuel Dumas
    Imperial College London, Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Genet 39:666-72. 2007
    ....
  86. ncbi Metabolism in the era of molecular biology
    Richard W Hanson
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 280:1705-15. 2005
  87. ncbi Influence of temperature on metabolism and breathing during mammalian ontogenesis
    Jacopo P Mortola
    Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Que, Canada H3G 1Y6
    Respir Physiol Neurobiol 149:155-64. 2005
    ..Presumably, this indicates that respiratory regulation develops independently from the individual's metabolic history...
  88. ncbi The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects
    M Boschmann
    Franz Volhard Clinical Research Center, Charité Campus Buch and HELIOS Klinikum, Berlin, Berlin, Germany
    Horm Metab Res 38:323-9. 2006
    ..The phenomenon could be related to a direct angiotensin II effect on tissue metabolism. To address the issue, we recruited eighteen obese hypertensive patients...
  89. ncbi From prebiotic chemistry to cellular metabolism--the chemical evolution of metabolism before Darwinian natural selection
    Enrique Meléndez-Hevia
    Instituto del Metabolismo Celular, Calle Manuel de Falla no 15, La Laguna, 38208 Tenerife, Canary Islands, Spain
    J Theor Biol 252:505-19. 2008
    It is generally assumed that the complex map of metabolism is a result of natural selection working at the molecular level...
  90. pmc 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking
    Mercedes Pozuelo Rubio
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 379:395-408. 2004
    ..cell growth, regulators of cell proliferation, including enzymes of DNA replication, proteins of anti-oxidative metabolism, regulators of actin dynamics and cellular trafficking, and proteins whose deregulation has been implicated in ..
  91. ncbi Metabolism and calcium antagonism of sodium alginate oligosaccharides
    Takamitsu Chaki
    Central Research Institute, Maruha Group Inc, Tsukuba, Ibaraki, Japan
    Biosci Biotechnol Biochem 71:1819-25. 2007
    ..Our results suggest that NaAOs are substantially excreted into the feces, although some of them may be absorbed internally, exerting antagonist activity towards the calcium channels, especially voltage-operated calcium channels...
  92. ncbi Depression of cell metabolism and proliferation by membrane-permeable and -impermeable modulators: role for AMP-to-ATP ratio
    Michael A Menze
    Division of Cellular, Developmental and Integrative Biology, Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Am J Physiol Regul Integr Comp Physiol 288:R501-10. 2005
    ..a nonhydrolyzable analog of 5'-AMP and potent activator of AMP-activated protein kinase, significantly depresses metabolism and proliferation of macrophages...
  93. ncbi The trade-off between rate and yield in the design of microbial metabolism
    S A Frank
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    J Evol Biol 23:609-13. 2010
    ....
  94. pmc A network perspective on metabolism and aging
    Quinlyn A Soltow
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Integr Comp Biol 50:844-54. 2010
    ..Here, we advocate the use of metabolic networks to expand the work from genomics and proteomics. As metabolism is the final fingerprint of functionality and has been implicated in multiple theories of aging, metabolomic ..
  95. ncbi The modulation of androgen metabolism by estradiol, minocycline, and indomethacin in a cell culture model
    A Tilakaratne
    Department of Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka
    J Periodontol 73:585-90. 2002
    ..to clarify the proanabolic effects of minocycline and indomethacin by studying their effects on androgen metabolism and mediation by estradiol...
  96. ncbi Effects of dietary fatty acids and exercise on body-weight regulation and metabolism in rats
    Michael Pellizzon
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA
    Obes Res 10:947-55. 2002
    To assess the interaction of high-fat diets (HF) made with different dietary fatty acids and exercise on body-weight regulation, adiposity, and metabolism.
  97. ncbi Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme
    Cynthia B Elias
    Animal Cell Technology Dept, Biotechnology Research Institute, Montreal, Quebec, Canada H4P 2R2, and Cell Culture Technology Dept, German Research Centre for Biotechnology mbH, Braunschweig, Germany
    Biotechnol Prog 19:90-7. 2003
    ..Differences in the amino acid utilization pattern were also observed, indicating changes in the basic metabolism of the cells...
  98. doi Sleep and metabolism: shared circuits, new connections
    Antoine Adamantidis
    Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA 94304 5742, USA
    Trends Endocrinol Metab 19:362-70. 2008
    ..New optical tools that remotely control neuronal circuit activity provide an effective means to understand the cooperativity of shared circuits in regulating hypothalamic functions such as sleep and metabolism.
  99. ncbi Hydroxycitrate has long-term effects on feeding behavior, body weight regain and metabolism after body weight loss in male rats
    Monika Leonhardt
    Institute of Animal Sciences, Swiss Federal Institute of Technology, CH 8603 Schwerzenbach, Switzerland
    J Nutr 132:1977-82. 2002
    ..The fact that HCA did not change plasma BHB concentration does not support a role for increased hepatic fatty acid oxidation in the anorectic effect of HCA...
  100. ncbi Metabonomics in toxicology: a review
    Donald G Robertson
    Metabonomics Evaluation Group, Department of World Wide Safety Sciences, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Sci 85:809-22. 2005
    ..The jargon, logistics, and applications of the technology are covered in some detail with emphasis on recent work in the field...
  101. ncbi METATOOL: for studying metabolic networks
    T Pfeiffer
    Humboldt University Berlin, Institute of Biology, Invalidenstrasse 42, D 10115 Berlin, Germany
    Bioinformatics 15:251-7. 1999
    ..In addition, we define 'enzyme subsets' to be groups of enzymes that operate together in fixed flux proportions in all steady states of the system...

Research Grants87

  1. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen Beverley; Fiscal Year: 2009
    ..identified through the study of antifolate-resistant Leishmania parasites, which has lead us into studies of the metabolism of the unconjugated pteridine biopterin and the conjugated pteridine folate, and the development and application ..
  2. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  4. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  5. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 2000
    ..Dr. Tompkins' research interests in tissue engineering and artificial organs development and in metabolism and physiological transport in injury are supported by competitive outside funding. Dr...
  6. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 2002
    ..Dr. Tompkins' research interests in tissue engineering and artificial organs development and in metabolism and physiological transport in injury are supported by competitive outside funding. Dr...
  7. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 2001
    ..Dr. Tompkins' research interests in tissue engineering and artificial organs development and in metabolism and physiological transport in injury are supported by competitive outside funding. Dr...
  8. TRAINING IN BURNS AND TRAUMA RESEARCH
    Ronald Tompkins; Fiscal Year: 1999
    ..Dr. Tompkins' research interests in tissue engineering and artificial organs development and in metabolism and physiological transport in injury are supported by competitive outside funding. Dr...
  9. Administrative Resource
    Reese T Jones; Fiscal Year: 2011
    ..This is a powerful tool in studies of pharmacokinetics and metabolism, frequently used in bioavailability studies...
  10. ALTERED METABOLISM AND CARCINOGENESIS BY DES
    CORAL LAMARTINIERE; Fiscal Year: 1990
    ..of rats to hormones or hormonally-active xenobiotics alters endocrine secretion, sexual behavior, hepatic metabolism and susceptibility for genotoxicity and carcinogenesis in adult animals...
  11. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2012
    ..neuropeptide Y through the central thyroid axis and the melanocortin 4 receptor through hepatic thyroid hormone metabolism resulted in a 1st-author publication in Cell Metabolism...
  12. NUTRITION IN RETT SYNDROME
    KATHLEEN MOTIL; Fiscal Year: 2000
    The OBJECTIVE of this proposal is to characterize the components of protein and calcium metabolism that are altered and to estimate their contribution to the overall protein and calcium requirements of RS girls...
  13. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2010
    ..Thus, B6 nutrition is linked many vital cellular processes such as the synthesis of nucleotides and glutathione, metabolism of most amino acids, including sulfur amino acids, methylation processes, and gluconeogenesis...
  14. GCRC - CAP - Joan C. Lo, MD
    Haile Debas; Fiscal Year: 2002
    ..of important metabolic complications involving abnormalities of fat distribution, carbohydrate and lipid metabolism, and bone mineralization...
  15. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2009
    ..eCB/CB1 receptor signaling is involved in the regulation of food consumption and metabolism via multiple mechanisms: it regulates the rewarding properties of food via effects on central mesolimbic ..
  16. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    RUSSELL WILKE; Fiscal Year: 2009
    ..eCB/CB1 receptor signaling is involved in the regulation of food consumption and metabolism via multiple mechanisms: it regulates the rewarding properties of food via effects on central mesolimbic ..
  17. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2010
    ..eCB/CB1 receptor signaling is involved in the regulation of food consumption and metabolism via multiple mechanisms: it regulates the rewarding properties of food via effects on central mesolimbic ..
  18. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): One-carbon metabolism is a critical pathway in cancer epigenetics because it directs the methylation of DNA and RNA and is involved in DNA synthesis and repair...
  19. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): One-carbon metabolism is a critical pathway in cancer epigenetics because it directs the methylation of DNA and RNA and is involved in DNA synthesis and repair...
  20. TOXICOLOGICAL SIGNIFICANCE OF ALKYLBENZENE METABOLISM
    Wayne Backes; Fiscal Year: 1999
    ..Benzene has been reported to be one of the most hazardous of the small aromatic hydrocarbons due to its metabolism by aromatic hydroxylation via reactive epoxide intermediates...
  21. TOXICOLOGICAL SIGNIFICANCE OF ALKYLBENZENE METABOLISM
    Wayne Backes; Fiscal Year: 2000
    ..Benzene has been reported to be one of the most hazardous of the small aromatic hydrocarbons due to its metabolism by aromatic hydroxylation via reactive epoxide intermediates...
  22. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..One adverse action of alcohol involves promotion of tissue and organ damage by impairing retinoid metabolism and actions in liver (where 70% of the body's retinoid is stored) and in peripheral tissues...
  23. Retinoid Metabolism and Alcohol Induced Disease
    WILLIAM BLANER; Fiscal Year: 2009
    ..One adverse action of alcohol involves promotion of tissue and organ damage by impairing retinoid metabolism and actions in liver (where 70% of the body's retinoid is stored) and in peripheral tissues...
  24. Cellular Efflux and Metabolism of Protease Inhibitors
    Ashim Mitra; Fiscal Year: 2002
    ..of this study is to classify all anti-AIDS drugs, currently used clinically, under a new proposed Absorption-Metabolism Classification System (AMCS)...
  25. Cellular Efflux and Metabolism of Protease Inhibitors
    Ashim Mitra; Fiscal Year: 2003
    ..of this study is to classify all anti-AIDS drugs, currently used clinically, under a new proposed Absorption-Metabolism Classification System (AMCS)...
  26. Cellular Efflux and Metabolism of Protease Inhibitors
    Ashim Mitra; Fiscal Year: 2004
    ..of this study is to classify all anti-AIDS drugs, currently used clinically, under a new proposed Absorption-Metabolism Classification System (AMCS)...
  27. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2007
    ..is to characterize how specific types of triglycerides (TG) in intravenous (IV) lipid emulsions affect particle metabolism and impact upon the biological potentials of their component lipids...
  28. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    Keywords;Absorption;Distribution;Metabolism;Excretion;ADME;Metabolite identification;toxicokinetics;Mechanisms of toxicity;2,3-butanedione;diacetyl;N,N-dimethylacetoacetamide;obliterative bronchiolitis;CYP;eugenol;safrole;estragole;..
  29. DETERMINANTS OF PUBERTAL CHANGES IN BONE MINERAL METABOLISM
    Steven Abrams; Fiscal Year: 1999
    ..relationships among balance, biochemical, hormonal, kinetic and densitometric parameters of bone mineral metabolism in early adolescent girls...
  30. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley Britigan; Fiscal Year: 2009
    ..Lung myeloid dendritic cells are a newly recognized reservoir of M.tb during lung infection. M.tb metabolism in macrophages and dendritic cells may differ. Iron (Fe) acquisition is critical for M.tb growth...
  31. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
    ..identified through the study of antifolate-resistant Leishmania parasites, which has lead us into studies of the metabolism of the unconjugated pteridine biopterin and the conjugated pteridine folate, and the development and application ..
  32. COOXIDATION AND THE TOXICITY OF CYCLOPHOSPHAMIDE
    JAMES KEHRER; Fiscal Year: 1992
    ..which is unstable and spontaneously breaks down to alkylating species, and to determine the importance of such metabolism in the lung and bladder toxicity of this drug...
  33. Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid Metabolism
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2011
    ..development and thereafter remain quiescent unless inappropriately activated in cancer, in regulation of hepatic metabolism through its interaction with FoxO1, a transcription factor known to modulate insulin sensitivity...
  34. ROUTES OF IFOSFAMIDE METABOLISM
    Lowell Anthony; Fiscal Year: 1992
    ..The specific aims of this project include: a) developing techniques to quantitate the metabolism of IFOS b) to compare the metabolism of CPA to IFOS and identify factors significantly influencing IFOS' ..
  35. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    WILLIAM PANDAK; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Proposal Summary/Abstract Disordered regulation of hepatic lipid metabolism is found in a variety of important disorders...
  36. Initiation, persistence, and progression of hepatocellular carcinoma
    Edward E Schmidt; Fiscal Year: 2010
    ..However, the complexities of liver metabolism have kept this goal out of reach...
  37. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2009
    Regulation of methylation is intimately associated with folate metabolism. These two metabolic processes are connected by the enzyme, glycine N-methyltransferase, which is abundant in liver, exocrine pancreas and prostate as well as in ..
  38. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2009
    Regulation of methylation is intimately associated with folate metabolism. These two metabolic processes are connected by the enzyme, glycine N-methyltransferase, which is abundant in liver, exocrine pancreas and prostate as well as in ..
  39. CONTROL OF PROTEIN AND ENERGY METABOLISM BY EPINEPHRIN
    Dwight Matthews; Fiscal Year: 1999
    ..These results suggest that the effect of epinephrine infusion on amino acid metabolism is to increase the metabolic efficiency of amino acid metabolism allowing rates of amino acid flux to proceed ..
  40. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2010
    Regulation of methylation is intimately associated with folate metabolism. These two metabolic processes are connected by the enzyme, glycine N-methyltransferase, which is abundant in liver, exocrine pancreas and prostate as well as in ..
  41. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael Donnino; Fiscal Year: 2010
    ..Vitamin B1 (thiamine) is a co-factor for pyruvate dehydrogenase, an essential enzyme for aerobic metabolism. In the absence of thiamine, the conversion of pyruvate to acetyl-CoA is inhibited and pyruvate cannot enter the ..
  42. REGULATION OF LIPID METABOLISM IN BACTERIA
    Charles O Rock; Fiscal Year: 2011
    ..The long term goal of the research program is to understand the biochemical and genetic regulation of lipid metabolism and membrane homeostasis in bacteria...
  43. Interrelationships among nutrients involved in one-carbon metabolism in Banglades
    MEGAN NINA HALL; Fiscal Year: 2010
    ..study management and oversight, 2) advanced nutritional biochemistry and the mathematical modeling of one-carbon metabolism, and 3) laboratory sciences...
  44. THE ROLE OF LIPOXINS IN BONE CELL METABOLISM
    Dimitris Tatakis; Fiscal Year: 1991
    ..that leukotrienes (arachidonic acid metabolites derived from the lipoxygenase pathway) may also affect bone metabolism. However, there appears to be no information available about the possible role of lipoxins in bone physiology...
  45. SURGERY--PROTEIN BREAKDOWN AND ENDOGENOUS OPIATES
    Naji Abumrad; Fiscal Year: 1993
    ..characterized by alterations in the neuroendocrine responses and in abnormalities in carbohydrate and amino acid metabolism. The abnormalities in glucose metabolism occur early and are characterized by sustained hyperglycemia resulting ..
  46. Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate
    MARY VELESCA GAMBLE; Fiscal Year: 2011
    ..As (InAs) is methylated to methylarsonic (MMA) and dimethylarsinic (DMA) acids via folate- dependent one-carbon metabolism. A reduced capacity to fully methylate As to DMA is associated with reduced urinary elimination of As...
  47. NEUROPEPTIDE Y--EFFECTS ON ENERGY METABOLISM
    Charles Billington; Fiscal Year: 1993
    This proposal focuses on the possibility that a central controller of energy metabolism might exist, a controller which influences not only food intake but provides complementary regulation of energy metabolism as well...
  48. Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate
    MARY VELESCA GAMBLE; Fiscal Year: 2010
    ..As (InAs) is methylated to methylarsonic (MMA) and dimethylarsinic (DMA) acids via folate- dependent one-carbon metabolism. A reduced capacity to fully methylate As to DMA is associated with reduced urinary elimination of As...
  49. NEUROPEPTIDE Y--EFFECTS ON ENERGY METABOLISM
    Charles Billington; Fiscal Year: 1992
    This proposal focuses on the possibility that a central controller of energy metabolism might exist, a controller which influences not only food intake but provides complementary regulation of energy metabolism as well...
  50. Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate
    MARY VELESCA GAMBLE; Fiscal Year: 2011
    ..As (InAs) is methylated to methylarsonic (MMA) and dimethylarsinic (DMA) acids via folate- dependent one-carbon metabolism. A reduced capacity to fully methylate As to DMA is associated with reduced urinary elimination of As...
  51. NEUROPEPTIDE Y--EFFECTS ON ENERGY METABOLISM
    Charles Billington; Fiscal Year: 1991
    This proposal focuses on the possibility that a central controller of energy metabolism might exist, a controller which influences not only food intake but provides complementary regulation of energy metabolism as well...
  52. Homocysteine, Adiponectin, and Alcoholic Liver Disease
    Zhenyuan Song; Fiscal Year: 2009
    ..an adipokine predominantly secreted by adipose tissue, plays a central role in the regulation of energy metabolism, lipid and carbohydrate metabolism...
  53. Homocysteine, Adiponectin, and Alcoholic Liver Disease
    Zhenyuan Song; Fiscal Year: 2010
    ..an adipokine predominantly secreted by adipose tissue, plays a central role in the regulation of energy metabolism, lipid and carbohydrate metabolism...
  54. Perilipin and cellular triacylglycerol metabolism
    Dawn L Brasaemle; Fiscal Year: 2010
    ..Dysregulation of adipose TAG metabolism in obese individuals leads to release of excess fatty acids into circulation, which contributes to the ..
  55. Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT
    Donna Parker; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT Principal Investigator: Parker, Donna R...
  56. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1992
    ..Apo E plays an important role in cholesterol metabolism by virtue of its interaction with cell surface receptors...
  57. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1993
    ..Apo E plays an important role in cholesterol metabolism by virtue of its interaction with cell surface receptors...
  58. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    Mary Reyland; Fiscal Year: 1990
    ..Apo E plays an important role in cholesterol metabolism by virtue of its interaction with cell surface receptors...
  59. POLY-A FUNCTION AND METABOLISM IN SACCHAROMYCES CEREVIS
    Alan Sachs; Fiscal Year: 1990
    How genes are differentially regulated by altering the metabolism of their mature mRNA is a key question in molecular biology...
  60. NITROSAMINE METABOLISM AND ESOPHAGEAL CANCER
    SIDNEY MIRVISH; Fiscal Year: 1992
    ..The following new studies are proposed. 1. Microsomal metabolism of NMAA: We will improve our method of isolating rat esophageal microsomes, study NMAA and N-..
  61. BIOCHEMISTRY OF SUPPLEMENTAL CHOLINE IN THE PRENATAL RAT
    Steven Zeisel; Fiscal Year: 1999
    ..We described changes in fetal and metal choline metabolism when mother's choline intake was varied. We characterized the choline content of human milk and infant formulas...
  62. BIOCHEMISTRY OF SUPPLEMENTAL CHOLINE IN THE PRENATAL RAT
    Steven Zeisel; Fiscal Year: 2000
    ..We described changes in fetal and metal choline metabolism when mother's choline intake was varied. We characterized the choline content of human milk and infant formulas...
  63. BIOCHEMISTRY OF SUPPLEMENTAL CHOLINE IN THE PRENATAL RAT
    Steven Zeisel; Fiscal Year: 2001
    ..We described changes in fetal and metal choline metabolism when mother's choline intake was varied. We characterized the choline content of human milk and infant formulas...
  64. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The uptake and metabolism of ketone bodies in brain have been of interest to researchers and clinicians for decades but how they affect the coupling of blood flow and glucose metabolism, especially ..
  65. Energy Balance During Ketosis in Rat Brain
    Joseph LaManna; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The uptake and metabolism of ketone bodies in brain have been of interest to researchers and clinicians for decades but how they affect the coupling of blood flow and glucose metabolism, especially ..
  66. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia Ulrich; Fiscal Year: 2009
    ..of genetic variability and biomarkers in two specific pathways - inflammation and folate-mediated one-carbon metabolism - in colorectal cancer etiology within a large cohort of women...
  67. PUBERTAL CHANGES IN BONE MINERAL METABOLISM
    Steven Abrams; Fiscal Year: 1999
    ..accumulation is maximal during puberty, it is essential to understand the factors associated with mineral metabolism during this period of time...
  68. PUBERTAL CHANGES IN BONE MINERAL METABOLISM
    Steven Abrams; Fiscal Year: 1999
    ..accumulation is maximal during puberty, it is essential to understand the factors associated with mineral metabolism during this period of time...
  69. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ..This revision also serves to create new research objectives to explore the associations of nicotine metabolism and oxidative stress genetics outside of the scope of the parent grant, and will be completed in less than one ..
  70. Chiral Microchip Electrophoresis - Mass Spectrometric Methods for Metabolic Studi
    Yiming Liu; Fiscal Year: 2010
    ..provided by applicant): The research is to determine the effects of chemical stimuli on the biosynthesis and metabolism of (R)-NMSal (a Parkinsonian neurotoxin) and to characterize the cellular uptake and release of D-Ser (a ..
  71. PUBERTAL CHANGES IN BONE MINERAL METABOLISM
    Steven Abrams; Fiscal Year: 2000
    ..accumulation is maximal during puberty, it is essential to understand the factors associated with mineral metabolism during this period of time...
  72. PUBERTAL CHANGES IN BONE MINERAL METABOLISM
    Steven Abrams; Fiscal Year: 1999
    ..accumulation is maximal during puberty, it is essential to understand the factors associated with mineral metabolism during this period of time...
  73. PUBERTAL CHANGES IN BONE MINERAL METABOLISM
    Steven Abrams; Fiscal Year: 2000
    ..accumulation is maximal during puberty, it is essential to understand the factors associated with mineral metabolism during this period of time...
  74. Quantitation of Tocopherol Metabolism in Humans
    Andrew Clifford; Fiscal Year: 2009
    ..Still, more research on vitamin E is needed to fully understand its metabolism and function(s). The IOM/NAS has listed key research recommendations for vitamin E...
  75. Nicotine Metabolism and the Development of Addiction in Adolescent Light Smokers
    Mark Rubinstein; Fiscal Year: 2009
    ..have shown that adult smokers with the presence of certain genetic markers associated with slower nicotine metabolism smoke fewer cigarettes and are more likely to quit...
  76. The Use of 2-Deoxyglucose in Head and Neck Cancer Therapy
    Douglas Spitz; Fiscal Year: 2009
    Cancer cells in general, relative to normal cells, demonstrate increased glucose metabolism but the mechanism for this is unknown...
  77. The Use of 2-Deoxyglucose in Head and Neck Cancer Therapy
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2010
    Cancer cells in general, relative to normal cells, demonstrate increased glucose metabolism but the mechanism for this is unknown...
  78. The Use of 2-Deoxyglucose in Head and Neck Cancer Therapy
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2011
    Cancer cells in general, relative to normal cells, demonstrate increased glucose metabolism but the mechanism for this is unknown...
  79. CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE
    Cynthia Morris; Fiscal Year: 1990
    The importance of maintaining dietary calcium intake and normal calcium metabolism for optimal regulation of arterial pressure in humans and experimental models has been demonstrated by us and other investigators...
  80. DICHLOROACETATE KINETICS, METABOLISM AND HUMAN TOXICOLOGY
    PETER STACPOOLE; Fiscal Year: 1999
    Dichloroacetate (DCA) is a product of water chlorination and the metabolism of the industrial solvents tri-chloroethylene and perchlorethylene...
  81. DYNAMICS OF IRON METABOLISM IN NEUROGLIA
    James Connor; Fiscal Year: 1993
    Because iron is an essential component of oxidative metabolism and a potent toxin, an exquisite system for regulating the availability of iron has been developed...
  82. DICHLOROACETATE KINETICS, METABOLISM AND HUMAN TOXICOLOGY
    PETER STACPOOLE; Fiscal Year: 1999
    Dichloroacetate (DCA) is a product of water chlorination and the metabolism of the industrial solvents tri-chloroethylene and perchlorethylene...
  83. C MYC--TRANSCRIPTION AND APOPTOSIS
    CHI DANG; Fiscal Year: 2009
    ..genome wide measure of nuclear run-on rates reveal a new link between MYC and E2F, regulation of nucleotide metabolism and cell cycle transit...