Summary: The sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosysthesis) and catabolism; the buildup and breakdown of molecules for utilization by the body.

Top Publications

  1. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
  2. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
  3. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
  4. ncbi Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
  5. ncbi Network biology: understanding the cell's functional organization
    Albert Laszlo Barabasi
    Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Nat Rev Genet 5:101-13. 2004
  6. ncbi The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    M Hucka
    Control and Dynamical Systems, MC 107 81, California Institute of Technology, Pasadena, CA 91125, USA
    Bioinformatics 19:524-31. 2003
  7. ncbi Hierarchical organization of modularity in metabolic networks
    E Ravasz
    Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 297:1551-5. 2002
  8. pmc The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    Charles E Massie
    CRUK Cambridge Research Institute, Cambridge, UK
    EMBO J 30:2719-33. 2011
  9. pmc Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood
    Elinor L Sullivan
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroendocrinology 93:1-8. 2011
  10. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005

Detail Information

Publications294 found, 100 shown here

  1. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
    ..The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes...
  2. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
    ..Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions...
  3. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
    ..More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks...
  4. ncbi Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
    The alterations in myocardial energy substrate metabolism that occur in heart failure, and the causes and consequences of these abnormalities, are poorly understood...
  5. ncbi Network biology: understanding the cell's functional organization
    Albert Laszlo Barabasi
    Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Nat Rev Genet 5:101-13. 2004
  6. ncbi The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    M Hucka
    Control and Dynamical Systems, MC 107 81, California Institute of Technology, Pasadena, CA 91125, USA
    Bioinformatics 19:524-31. 2003
    ..Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively...
  7. ncbi Hierarchical organization of modularity in metabolic networks
    E Ravasz
    Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 297:1551-5. 2002
    ..Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization...
  8. pmc The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    Charles E Massie
    CRUK Cambridge Research Institute, Cambridge, UK
    EMBO J 30:2719-33. 2011
    ..cancer and regulates cancer cell growth via its unexpected role as a hormone-dependent modulator of anabolic metabolism. In conclusion, it is possible to progress from transcriptional studies to a promising therapeutic target by ..
  9. pmc Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood
    Elinor L Sullivan
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroendocrinology 93:1-8. 2011
    ..The perinatal environment plays an important role in programming many aspects of physiology and behavior including metabolism, body weight set point, energy balance regulation and predisposition to mental health-related disorders such as ..
  10. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005
    ..model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as the cell cycle...
  11. pmc Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
    Robert Schuetz
    Institute of Molecular Systems Biology, ETH Zurich, Switzerland
    Mol Syst Biol 3:119. 2007
  12. ncbi At the crossroad between immunity and metabolism: focus on leptin
    Javier Conde
    Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammation Disease, Building C, Level 2, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Calle Choupana s n, Santiago de Compostela, 15706, Spain
    Expert Rev Clin Immunol 6:801-8. 2010
    ..most important adipokines secreted by fat cells, with a variety of physiological roles related to the control of metabolism, energy homeostasis and inflammatory response...
  13. pmc A role for gene duplication and natural variation of gene expression in the evolution of metabolism
    Daniel J Kliebenstein
    Department of Plant Sciences, University of California Davis, Davis, California, United States of America
    PLoS ONE 3:e1838. 2008
    ..Finally, the ability of gene duplicates to diverge may be limited by their biological function...
  14. ncbi Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences
    Nicholas A Burd
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster Univ, 1280 Main St, West Hamilton, ON, Canada L8S 4K1
    J Appl Physiol (1985) 106:1692-701. 2009
    ..Furthermore, we examine the underlying anabolic signaling pathways and molecules that regulate these processes...
  15. ncbi FGFs and metabolism
    Alexei Kharitonenkov
    Eli Lilly and Company, Lilly Research Laboratories, Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Curr Opin Pharmacol 9:805-10. 2009
    ..morphogenesis, angiogenesis, hematopoiesis, and survival, this decade provided clues on FGF roles in metabolism. In particular, 'hormone-like' FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, ..
  16. pmc Expansion of the BioCyc collection of pathway/genome databases to 160 genomes
    Peter D Karp
    Bioinformatics Research Group, SRI International EK207, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Nucleic Acids Res 33:6083-9. 2005
    ..Only by harnessing the expertise of many scientists we can hope to produce biological databases, which accurately reflect the depth and breadth of knowledge that the biomedical research community is producing...
  17. pmc Coral larvae under ocean acidification: survival, metabolism, and metamorphosis
    Masako Nakamura
    Sesoko Station, Tropical Biosphere Research Center, University of the Ryukyus, Okinawa, Japan
    PLoS ONE 6:e14521. 2011
    ..These results imply that acidified seawater impacts larval physiology, suggesting that suppressed metabolism and metamorphosis may alter the dispersal potential of larvae and subsequently reduce the resilience of coral ..
  18. ncbi The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Biochem 43:732-44. 2010
    ..Its metabolism methylates homocysteine to methionine, also producing N,N-dimethylglycine...
  19. pmc The KEGG databases at GenomeNet
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 30:42-6. 2002
    ..The KEGG databases are updated daily and made freely available (
  20. ncbi Epigenetics and metabolism in 2011: Epigenetics, the life-course and metabolic disease
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Rev Endocrinol 8:74-6. 2012
    ..Data published in 2011 suggest that epigenetic analysis could potentially have utility as a marker of early metabolic pathology and might enable early life prophylaxis...
  21. ncbi Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)
    Ravi Kumar Sangeetha
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, CSIR, Mysore, 570 020, India
    Mol Cell Biochem 333:299-310. 2010
    This study reports bioavailability and metabolism of fucoxanthin (FUCO) from brown algae Padina tetrastromatica in rats. Rats were divided into two groups (n = 25/group)...
  22. ncbi Metabolite profiling for plant functional genomics
    O Fiehn
    Max Planck Institute of Molecular Plant Physiology, 14424 Potsdam, Germany
    Nat Biotechnol 18:1157-61. 2000
    ..These results demonstrate the use of metabolite profiling as a tool to significantly extend and enhance the power of existing functional genomics approaches...
  23. ncbi A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum
    Uly Nasution
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Metab Eng 10:10-23. 2008
    The relation between central metabolism and the penicillin biosynthesis pathway in Penicillium chrysogenum was studied by manipulating the steady-state flux in both pathways...
  24. ncbi Internal desynchronization in a model of night-work by forced activity in rats
    R Salgado-Delgado
    Departamento de Anatomia, Facultad de Medicina, Edificio B 4 Piso, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
    Neuroscience 154:922-31. 2008
    ..The present data suggest that in the night worker the combination of work and eating during working hours may be the cause of internal desynchronization...
  25. ncbi Diet, metabolism and lifespan in Drosophila
    Matthew D W Piper
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Gerontol 40:857-62. 2005
    ..Current data indicate lifespan-extension by DR is likely to involve both enhancement of various defense and detoxification mechanisms and a complex range of metabolic alterations that make energy available for these processes...
  26. pmc Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008
    ..To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial...
  27. ncbi From measurements of metabolites to metabolomics: an 'on the fly' perspective illustrated by recent studies of carbon-nitrogen interactions
    Mark Stitt
    Departments of Metabolic Networks and Molecular Physiology, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Curr Opin Biotechnol 14:136-44. 2003
    ..A major future challenge concerns the integration of the information gained from metabolite profiling into an accessible body of knowledge...
  28. pmc Choline metabolism and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 22:2045-52. 2008
    Choline is an essential nutrient required for methyl group metabolism, but its role in carcinogenesis and tumor progression is not well understood...
  29. pmc Dynamic flux balance analysis of diauxic growth in Escherichia coli
    Radhakrishnan Mahadevan
    Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716 USA
    Biophys J 83:1331-40. 2002
    ..Therefore, dynamic FBA provides a framework for analyzing the transience of metabolism due to metabolic reprogramming and for obtaining insights for the design of metabolic networks.
  30. ncbi Regulation of growth and metabolism by imprinted genes
    F M Smith
    Centre for Regenerative Medicine and Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath, UK
    Cytogenet Genome Res 113:279-91. 2006 influence energy homeostasis and some, including Igf2 and Grb10, may coordinate growth with glucose-regulated metabolism. Since perturbation of fetal growth can be correlated with metabolic disorders in adulthood these imprinted ..
  31. ncbi Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response
    Valerio Gozzoli
    Surgical Intensive Care Division, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Intensive Care Med 30:401-7. 2004
    ..We investigated the metabolic, hemodynamic, and inflammatory responses of pharmacological and physical therapies aimed at reducing body temperature in febrile critically ill patients...
  32. ncbi Genome-scale microbial in silico models: the constraints-based approach
    Nathan D Price
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 2093 0412, USA
    Trends Biotechnol 21:162-9. 2003
    ..These results are useful as a basis for iterative model building and for several practical applications...
  33. ncbi Bow ties, metabolism and disease
    Marie Csete
    Emory Anesthiology Research Labs, 1462 Clifton Rd NE, Room 420, Atlanta GA 30322, USA
    Trends Biotechnol 22:446-50. 2004
    ..Large-scale organizational frameworks such as the bow tie are necessary starting points for higher-resolution modeling of complex biologic processes..
  34. pmc The hypocretins as sensors for metabolism and arousal
    Antoine Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5742, USA
    J Physiol 587:33-40. 2009
    ..Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions...
  35. ncbi NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology
    Muireann Coen
    Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK
    Chem Res Toxicol 21:9-27. 2008
    ..The use of biological fluids as a source of whole organism metabolic information enhances the use of this approach in minimally invasive longitudinal studies...
  36. pmc Computational prediction of human metabolic pathways from the complete human genome
    Pedro Romero
    Bioinformatics Research Group, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Genome Biol 6:R2. 2005
    ..Pathway assignments place genes in their larger biological context, and are a necessary first step toward quantitative modeling of metabolism.
  37. pmc Metabolism strikes back: metabolic flux regulates cell signaling
    Christian M Metallo
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 24:2717-22. 2010
    ..This mechanism ensures that cells do not engage in anabolic metabolism when nutrients are limiting, and highlights how substrate availability for protein modifications can modulate ..
  38. pmc Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
    David Leitsch
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Antimicrob Chemother 66:1756-65. 2011
    ..Resistance to metronidazole has been associated with down-regulation of PFOR and Fd. The aim of this study was to determine whether the PFOR/Fd couple is the only pathway involved in metronidazole activation in Giardia...
  39. pmc From sirtuin biology to human diseases: an update
    Carlos Sebastian
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 287:42444-52. 2012
    ..In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas...
  40. ncbi The fourth dimension of life: fractal geometry and allometric scaling of organisms
    G B West
    Theoretical Division, MS B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 284:1677-9. 1999
    ..These design principles are independent of detailed dynamics and explicit models and should apply to virtually all organisms...
  41. ncbi Evidence for a proximate influence of winter temperature on metabolism in passerine birds
    D L Swanson
    Department of Biology, University of South Dakota, Vermillion, SD 57069 2390, USA
    Physiol Biochem Zool 72:566-75. 1999
    ..Least-squares regression revealed significant negative relationships for normalized basal and summit metabolism against mean winter temperature for all species pooled (R2=0.62 to 0.69, P</=0.001)...
  42. ncbi 13C metabolic flux analysis
    W Wiechert
    Department of Simulation, IMR, University of Siegen, Paul Bonatz Strasse 9 11, D 57068 Siegen, Germany
    Metab Eng 3:195-206. 2001
    ..It allows the detailed quantification of all intracellular fluxes in the central metabolism of a microorganism...
  43. ncbi Organizational invariance and metabolic closure: analysis in terms of (M,R) systems
    Juan Carlos Letelier
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    J Theor Biol 238:949-61. 2006
    ..formulation of (M,R) systems in terms of mappings and sets of mappings, which is grounded in the metaphor of metabolism as a mathematical mapping...
  44. doi Diabetes and protein metabolism
    Niels Møller
    Medical Department M, Aarhus University Hospital, Medical Research Laboratories, Aarhus C 8000, Denmark
    Diabetes 57:3-4. 2008
  45. ncbi PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism
    Beatrice Desvergne
    Center of Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Cell Metab 7:467-9. 2008
    ..In two studies by Kang et al. (2008) and Odegaard et al. (2008) in this issue of Cell Metabolism, we learn that alternative activation (M2a) of resident macrophages in liver and adipose tissue depends highly ..
  46. ncbi Bone and metabolism: a complex crosstalk
    Liesbet Lieben
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Horm Res 71:134-8. 2009
    Until recently, communication from metabolism to bone was considered purely unidirectional, involving complex interactions among an adipocyte-derived factor (leptin), the sympathetic nervous system and neuropeptides...
  47. ncbi Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, Purdue UAB Botanicals Center for Age Related Disease, UAB Center for Nutrient Gene Interaction in Cancer Prevention, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Pharm 4:846-64. 2007
    ..behavior of these compounds following oral ingestion is needed as well as their absorption, distribution, metabolism, and excretion (ADME)...
  48. pmc Hypothalamic sites of leptin action linking metabolism and reproduction
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9077, USA
    Neuroendocrinology 93:9-18. 2011
    ..In this review, we discuss the recent advances in the field focused on the identification of potential site(s) or specific neuronal populations involved in leptin's effects in the neuroendocrine reproductive axis...
  49. ncbi Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression
    Weiling Zhao
    Department of Radiation Oncology, Brain Tumor Center of Wake Forest University, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Clin Cancer Res 12:3823-30. 2006
    ..As such, the aim of the present study was to identify candidate genes involved in the development of radiation injury in the murine kidney and brain using microarray analysis...
  50. ncbi Transplantation of adipose tissue and stem cells: role in metabolism and disease
    Thien T Tran
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Nat Rev Endocrinol 6:195-213. 2010
    ..metabolic effects, subcutaneous white adipose tissue and brown adipose tissue have the potential to benefit metabolism by improving glucose homeostasis and increasing energy consumption...
  51. ncbi H2S induced hypometabolism in mice is missing in sedated sheep
    Philippe Haouzi
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States
    Respir Physiol Neurobiol 160:109-15. 2008
    ..We measured metabolism in conscious mice (24 g) exposed to H(2)S (60 ppm) at an ambient temperature of 23-24 degrees C...
  52. ncbi A salvage pathway for phytol metabolism in Arabidopsis
    Till Ischebeck
    Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    J Biol Chem 281:2470-7. 2006
    ..Thus, Arabidopsis contains a distinct enzymatic machinery for redirecting free phytol released from chlorophyll degradation into chloroplast lipid metabolism.
  53. ncbi Adenine nucleotide metabolism in human blood--important roles for leukocytes and erythrocytes
    S Heptinstall
    Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, University of Nottingham, UK
    J Thromb Haemost 3:2331-9. 2005
    ..Rapid metabolism of ADP and ATP by endothelial cells is important in protecting platelets from their effects...
  54. ncbi The circadian clock and metabolism
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Clin Sci (Lond) 120:65-72. 2011
    ..and physiological functions in addition to the expression and/or activity of enzymes and hormones involved in metabolism. In turn, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism...
  55. pmc HMDB: the Human Metabolome Database
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 35:D521-6. 2007
    ..HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world...
  56. ncbi Effects of olanzapine and haloperidol on the metabolic status of healthy men
    Solrun Vidarsdottir
    Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 95:118-25. 2010
    ..The aim of this study was to determine the effect of short-term olanzapine (atypical antipsychotic drug) and haloperidol (conventional antipsychotic drug) treatment on glucose and lipid metabolism.
  57. ncbi Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    John C Lindon
    Biological Chemistry, Biomedical Sciences, Division, Faculty of Medicine, Imperial College London, UK
    Biomarkers 9:1-31. 2004, metabonomics, a combination of data-rich analytical chemical measurements and chemometrics for profiling metabolism in complex systems, is described and its applications are reviewed...
  58. ncbi Chemometrics in metabonomics
    Johan Trygg
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Sweden
    J Proteome Res 6:469-79. 2007
    ..This is illustrated by examples from the literature...
  59. pmc A minimal model of metabolism-based chemotaxis
    Matthew D Egbert
    Centre for Computational Neuroscience and Robotics, University of Sussex, Brighton, United Kingdom
    PLoS Comput Biol 6:e1001004. 2010
    Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption...
  60. ncbi Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
    Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science...
  61. ncbi Transcriptional regulation of metabolism
    Beatrice Desvergne
    Center for Integrative Genomics, National Centre of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Physiol Rev 86:465-514. 2006
    Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made towards elucidating the mechanisms controlling the major regulatory pathways are now being rewarded...
  62. ncbi Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats
    Anthony Fardet
    Unite de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Recherche de Clermont Ferrand Theix, F 63122 St Genes Champanelle, France
    J Nutr 138:1282-7. 2008
    ..The latter can be characterized by a metabolomics approach. In this work, we compared the metabolism of lignins to that of the structurally related ferulic acid (FA) and sinapic acid (SA)...
  63. ncbi Mitotic activity of rat muscle satellite cells in response to serum stimulation: relation with cellular metabolism
    Aude E Barani
    Laboratoire de Physiologie, Groupe Physiologie et Physiopathologie de l Exercice et du Handicap, Groupement d Intérêt Public Exercice Sport Santé, Faculte de Medecine, 15 rue Ambroise Paré, 42023 Saint Etienne, France
    Exp Cell Res 283:196-205. 2003
    ..of energetic and proteolytic metabolisms, including an increase in the relative contribution of glycolytic metabolism for energy production, an increase in proteasome and matrix metalloproteinases 2 and 9 activities, and a ..
  64. ncbi Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms
    Hongwu Ma
    GBF German Research Center for Biotechnology, Microbial Systems, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Bioinformatics 19:270-7. 2003
    ..These networks are often very large and complex. To properly understand and analyze the global properties of metabolic networks, methods for rationally representing and quantitatively analyzing their structure are needed...
  65. ncbi In vitro fertilization improves childhood growth and metabolism
    Harriet L Miles
    The National Research Centre for Growth and Development and Liggins Institute, University of Auckland, Auckland 1010, New Zealand
    J Clin Endocrinol Metab 92:3441-5. 2007
    ..There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase in rare imprinted gene disorders such as Beckwith-Wiedemann syndrome has been reported...
  66. ncbi Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation
    Christoph Handschin
    Biozentrum, University of Basel, Basel and Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Clin Exp Pharmacol Physiol 36:1139-43. 2009
    1. In higher eukaryotes, metabolism and immunity are tightly coupled...
  67. ncbi Altered body composition and metabolism in the male offspring of high fat-fed rats
    Alexandra J Buckley
    School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
    Metabolism 54:500-7. 2005
    ..fat can modify the programming of an offspring's glucose tolerance, insulin sensitivity, body composition, lipid metabolism, and insulin signaling...
  68. ncbi Online monitoring of cellular metabolism in the MCF-7 carcinoma cell line treated with phytoestrogen extracts
    S Abarzua
    Department Biological Sciences, University of Rostock, Institute of Biological Sciences, Rostock, Germany
    Anticancer Res 30:1587-92. 2010
    ..The aim of this study was to isolate phytoestrogens from the flax root of Linum usitatissimum and to test their effect on cellular metabolism in the human mammalian carcinoma cell line MCF-7 using the Bionas 2500 analysis system.
  69. ncbi Conserved metabolic regulatory functions of sirtuins
    Bjoern Schwer
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Cell Metab 7:104-12. 2008
    ..The earliest function of sirtuins therefore may have been regulation of cellular metabolism in response to nutrient availability...
  70. ncbi Intracellular mechanisms of metabolism regulation: the role of signaling via the mammalian target of rapamycin pathway and other routes
    Vincenzo Flati
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Am J Cardiol 101:16E-21E. 2008
    ..Our observations provide molecular evidence that supports the use of anabolic nutrients such as AAs, together with standard therapies, to overcome insulin resistance syndrome...
  71. pmc MicroRNAs in metabolism and metabolic diseases
    V Rottiers
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Cold Spring Harb Symp Quant Biol 76:225-33. 2011
    ..NAD(+)-dependent sirtuin SIRT6, and the insulin signaling intermediate IRS2, key regulators of glucose and lipid metabolism. These results have revealed a highly integrated microRNA (miRNA)-host gene circuit governing cholesterol/lipid ..
  72. ncbi Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function
    Mads Halbirk
    Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark
    Am J Physiol Heart Circ Physiol 299:H1220-5. 2010
    ..In conclusion, acipimox caused minor changes in whole body metabolism and decreased the FFA supply, but a long-term reduction in circulating FFAs with acipimox did not change ..
  73. pmc Integrating cellular metabolism into a multiscale whole-body model
    Markus Krauss
    Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany
    PLoS Comput Biol 8:e1002750. 2012
    Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology...
  74. pmc A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor
    Daniel Rozas
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    PLoS ONE 7:e31760. 2012
    ..Therefore, this two-component system in S. coelicolor seems to influence various processes characterised by the transition from primary to secondary metabolism, as determined by proteomic and transcriptomic analyses.
  75. ncbi Effects of intermittent hydrostatic pressure and BMP-2 on osteoarthritic human chondrocyte metabolism in vitro
    R L Smith
    Bone and Joint RR and D Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Orthop Res 29:361-8. 2011
  76. ncbi Effects of short-term oral salbutamol administration on exercise endurance and metabolism
    K Collomp
    Laboratoire National de Dépistage du Dopage, Chatenay Malabry, France
    J Appl Physiol (1985) 89:430-6. 2000
  77. ncbi Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients
    B J Bequette
    Department of Animal and Avian Sciences, University of Maryland, College Park, 20742, USA
    J Anim Sci 84:E50-9. 2006
    ..This paper highlights aspects of animal nutrition and metabolism in which [U-13C] substrates and MID can be applied to investigations of amino acid, carbohydrate, and fat ..
  78. pmc CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Sci Signal 2:re3. 2009
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development...
  79. ncbi Sir2 links chromatin silencing, metabolism, and aging
    L Guarente
    Department of Biology, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts 02139 USA
    Genes Dev 14:1021-6. 2000
  80. ncbi In silico techniques for the study and prediction of xenobiotic metabolism: a review
    S A Kulkarni
    Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
    Xenobiotica 35:955-73. 2005
    Knowledge about metabolism is very important to understand the health risks posed by chemicals...
  81. ncbi Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
    Fu Yang
    Department of Medical Genetics, Second Military Medical University, Shanghai, PR China
    J Hepatol 48:12-9. 2008
  82. ncbi Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
    Marc Emmanuel Dumas
    Imperial College London, Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Genet 39:666-72. 2007
  83. doi Nutrition and metabolism: non-alcoholic fatty liver disease - pathogenesis, cardiovascular risk and therapy
    Gerald F Watts
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Lipidol 19:92-4. 2008
  84. ncbi Evolution of the protein repertoire
    Cyrus Chothia
    Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 300:1701-3. 2003
    ..Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes...
  85. ncbi Regulatory roles of leptin in reproduction and metabolism: a comparative review
    D A Zieba
    Animal Reproduction Laboratory, Texas A and M University Agricultural Research Station, 3507 Hwy 59E, Beeville, TX 78102, USA
    Domest Anim Endocrinol 29:166-85. 2005
    ..Future therapeutic uses for recombinant leptin that exploit states of nutritional hypersensitization, and identification of genetic markers for genotypic variation in leptin resistance, are currently under investigation...
  86. ncbi Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery
    Mark P Styczynski
    Department of Chemical Engineering, Massachusetts Institute of Technology, Room 56 469c, Cambridge, Massachusetts 02139, USA
    Anal Chem 79:966-73. 2007
    ..By systematically cataloguing conserved metabolite peaks prior to data analysis methods, our approach broadens the scope of metabolomics and facilitates biomarker discovery...
  87. ncbi From prebiotic chemistry to cellular metabolism--the chemical evolution of metabolism before Darwinian natural selection
    Enrique Meléndez-Hevia
    Instituto del Metabolismo Celular, Calle Manuel de Falla no 15, La Laguna, 38208 Tenerife, Canary Islands, Spain
    J Theor Biol 252:505-19. 2008
    It is generally assumed that the complex map of metabolism is a result of natural selection working at the molecular level...
  88. pmc 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking
    Mercedes Pozuelo Rubio
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 379:395-408. 2004
    ..cell growth, regulators of cell proliferation, including enzymes of DNA replication, proteins of anti-oxidative metabolism, regulators of actin dynamics and cellular trafficking, and proteins whose deregulation has been implicated in ..
  89. ncbi Depression of cell metabolism and proliferation by membrane-permeable and -impermeable modulators: role for AMP-to-ATP ratio
    Michael A Menze
    Division of Cellular, Developmental and Integrative Biology, Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Am J Physiol Regul Integr Comp Physiol 288:R501-10. 2005
    ..a nonhydrolyzable analog of 5'-AMP and potent activator of AMP-activated protein kinase, significantly depresses metabolism and proliferation of macrophages...
  90. ncbi The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects
    M Boschmann
    Franz Volhard Clinical Research Center, Charité Campus Buch and HELIOS Klinikum, Berlin, Berlin, Germany
    Horm Metab Res 38:323-9. 2006
    ..The phenomenon could be related to a direct angiotensin II effect on tissue metabolism. To address the issue, we recruited eighteen obese hypertensive patients...
  91. ncbi Metabolism in the era of molecular biology
    Richard W Hanson
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 280:1705-15. 2005
  92. ncbi Influence of temperature on metabolism and breathing during mammalian ontogenesis
    Jacopo P Mortola
    Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Que, Canada H3G 1Y6
    Respir Physiol Neurobiol 149:155-64. 2005
    ..Presumably, this indicates that respiratory regulation develops independently from the individual's metabolic history...
  93. ncbi Metabolism and calcium antagonism of sodium alginate oligosaccharides
    Takamitsu Chaki
    Central Research Institute, Maruha Group Inc, Tsukuba, Ibaraki, Japan
    Biosci Biotechnol Biochem 71:1819-25. 2007
    ..Our results suggest that NaAOs are substantially excreted into the feces, although some of them may be absorbed internally, exerting antagonist activity towards the calcium channels, especially voltage-operated calcium channels...
  94. pmc A network perspective on metabolism and aging
    Quinlyn A Soltow
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Integr Comp Biol 50:844-54. 2010
    ..Here, we advocate the use of metabolic networks to expand the work from genomics and proteomics. As metabolism is the final fingerprint of functionality and has been implicated in multiple theories of aging, metabolomic ..
  95. ncbi The trade-off between rate and yield in the design of microbial metabolism
    S A Frank
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    J Evol Biol 23:609-13. 2010
  96. ncbi The modulation of androgen metabolism by estradiol, minocycline, and indomethacin in a cell culture model
    A Tilakaratne
    Department of Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka
    J Periodontol 73:585-90. 2002 clarify the proanabolic effects of minocycline and indomethacin by studying their effects on androgen metabolism and mediation by estradiol...
  97. ncbi Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme
    Cynthia B Elias
    Animal Cell Technology Dept, Biotechnology Research Institute, Montreal, Quebec, Canada H4P 2R2, and Cell Culture Technology Dept, German Research Centre for Biotechnology mbH, Braunschweig, Germany
    Biotechnol Prog 19:90-7. 2003
    ..Differences in the amino acid utilization pattern were also observed, indicating changes in the basic metabolism of the cells...
  98. ncbi Effects of dietary fatty acids and exercise on body-weight regulation and metabolism in rats
    Michael Pellizzon
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA
    Obes Res 10:947-55. 2002
    To assess the interaction of high-fat diets (HF) made with different dietary fatty acids and exercise on body-weight regulation, adiposity, and metabolism.
  99. ncbi Sleep and metabolism: shared circuits, new connections
    Antoine Adamantidis
    Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA 94304 5742, USA
    Trends Endocrinol Metab 19:362-70. 2008
    ..New optical tools that remotely control neuronal circuit activity provide an effective means to understand the cooperativity of shared circuits in regulating hypothalamic functions such as sleep and metabolism.
  100. ncbi Hydroxycitrate has long-term effects on feeding behavior, body weight regain and metabolism after body weight loss in male rats
    Monika Leonhardt
    Institute of Animal Sciences, Swiss Federal Institute of Technology, CH 8603 Schwerzenbach, Switzerland
    J Nutr 132:1977-82. 2002
    ..The fact that HCA did not change plasma BHB concentration does not support a role for increased hepatic fatty acid oxidation in the anorectic effect of HCA...
  101. ncbi Metabonomics in toxicology: a review
    Donald G Robertson
    Metabonomics Evaluation Group, Department of World Wide Safety Sciences, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Sci 85:809-22. 2005
    ..The jargon, logistics, and applications of the technology are covered in some detail with emphasis on recent work in the field...

Research Grants45

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  4. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..overload, heart disease, liver disease, endocrine dysfunction, nutritional deficiencies and disorders of bone metabolism. Our future goals include expanded screening for cardiac iron deposition using newly available MRI technology ..
  5. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..of human immune response genes using ~200,000 SNPs 2) A panel of ~ 200,000 SNPs covering the genes in human metabolism. 3) A [unreadable]genotyping[unreadable] platform capable of measuring DNA methylation in human samples using ..
  6. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..ranging from production and secretion of proteins such as albumin, clotting factors and antiproteases, to metabolism and excretion of exogenous compounds such as drugs or toxins as well as endogenous compounds like hormones, ..
  7. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..These changes may be due to direct ovarian effects on lipoprotein metabolism, and/or steroids secreted from the ovary having systemic effects on the liver or other organs...
  8. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..generation of GSH and the MTh flavonolignans are inducers of many cellular enzymes participating in GSH metabolism, including GSH-reductase (GSH-R), GSH-peroxidase (GSH-Px), GSH-S-transferases (GST) and superoxide dismutase (..
  9. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..standardized measures of vascular endothelial function, biomarkers of oxidant stress, modulators of nitric oxide metabolism and iron loading is critical for the understanding of sickle vasculopathy and must be accomplished before an ..
  10. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..eCB/CB1 receptor signaling is involved in the regulation of food consumption and metabolism via multiple mechanisms: it regulates the rewarding properties of food via effects on central mesolimbic ..
  11. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..maintenance of body weight are regulated by a concerted action of sensing peripheral nutrient status and energy metabolism to the brain which integrates the signals with central inputs of circadian rhythm and psychological stressors...
  12. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..Aim 2: We investigate the physiological requirement for PRDI\/I16 in BAT and whole body metabolism by creating and characterizing tissue-specific PRD/Wt6-deficient mice...
  13. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    ..a bone- derived hormone implicated in the pathogenesis of many human diseases including disorders of mineral metabolism and chronic kidney disease...
  14. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..g. reduced MW, LogP) and would provide one dimensional metabolism, pharmacokinetics, and safety profiles as opposed to co-administering two drugs where development metrics are ..
  15. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..Alterations in lysophospholipid metabolism and signaling also contribute to drug and radiation resistance, tumor angiogenesis, and progression of many ..
  16. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..So far, not a single study has examined the effects of CPAP on glucose metabolism specifically in prediabetes, a potentially reversible state in which the development of overt diabetes and its ..
  17. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..neuropeptide Y through the central thyroid axis and the melanocortin 4 receptor through hepatic thyroid hormone metabolism resulted in a 1st-author publication in Cell Metabolism...
  18. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Of particular interest are adaptive changes in proteins associated with metabolism, oxidative stress, and cell death...
  19. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..TRT on body composition (muscle CSA, VAT, %FM) and the metabolic profiles (glucose and lipid metabolism) in individuals with motor complete SCI...
    Patrice G Guyenet; Fiscal Year: 2013
    ..stresses such as infection, hypotension, pain and hypoxia and they also contribute to the regulation of glucose metabolism. Collectively, these data suggest that the C1 cells mediate neuroendocrine responses (sympathoadrenal activation,..
  21. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012 the principle biological methyl donor that is made in all mammalian cells as the first product of methionine metabolism, catalyzed by methionine adenosylmethionine (MAT)...
  22. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Mitochondrial dysfunction and abnormal fuel metabolism are linked to the development of obesity, diabetes and cardiovascular disease...
  23. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..CBS is a metabolic enzyme involved in the metabolism of sulfur containing amino acid such as methionine (Met)...
  24. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..B12 in the development of liver cancer;(4) to assess the role of genetic polymorphisms influencing methyl group metabolism in the development of liver cancer, and their modifying effect on the associations between methyl groups and ..
  25. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    ..These CYP26 inhibitors are also called retinoic acid metabolism blocking agents (RAMBAs)...
  26. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..In the INS resistant state, myocardial and skeletal muscle glucose uptake and metabolism is impaired, leading to diastolic dysfunction, attenuated myocardial and skeletal muscle blood flow, and ..
  27. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..Sphingolipids serve structural membrane functions, whereas their metabolism produces signaling molecules involved in regulating mammalian development, immune function, inflammation and ..
  28. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..I will develop a working knowledge of immunological function and understand the impact of cytokines and TRP-KYN metabolism on neuroinflammatory processes in the CNS. This training will take place under the mentorship of Drs...
  29. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..Directed changes in bacterial metabolism are made by modifying specific biochemical reactions or by introducing new ones...
  30. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..will determine whether one of two resistance exercise protocols improves pain, physical function, and cartilage metabolism in older persons with knee OA. This is a repeated-measures, three group design...
  31. Med1 in Liver Metabolism, Regeneration and Cancer
    Janardan K Reddy; Fiscal Year: 2013
    ..a pivotal role in energy homeostasis by orchestrating biochemical pathways of carbohydrate, fat, and protein metabolism and exhibits inherent compensatory regeneration capacity to regain partially lost metabolic functions...
    Gary Cecchini; Fiscal Year: 2013
    ..Reducing equivalents generated by the TCA cycle and fatty acid metabolism are used by NADH-ubiquinone reductase (complex I), succinate-ubiquinone reductase (complex II), and ETF-quinone ..
    Maureen J Charron; Fiscal Year: 2010
    ..studies are proposed to test the response of high fat IU offspring to diets that alter body weight and metabolism including a high fat diabetogenic diet or a weight loss ketogenic diet during their adult life...
  34. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009 whether MYCN overexpression in NB cells impacts endogenous ODC and other metabolic enzymes of polyamine metabolism, and whether this translates into changes in polyamine pools, cell cycle progression, and cell proliferation...
  35. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    DESCRIPTION: Androgen action is the net result of opposing pathways of steroid biosynthesis and metabolism. It is now widely recognized that testosterone (T) is an androgenic precursor of the more potent 5[unreadable]-dihydrotestosterone ..
  36. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..In the course of this work, other important and heretofore unknown connections between dietary iron and metabolism emerged...
  37. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..One adverse action of alcohol involves promotion of tissue and organ damage by impairing retinoid metabolism and actions in liver (where 70% of the body's retinoid is stored) and in peripheral tissues...
  38. Cellular Efflux and Metabolism of Protease Inhibitors
    Ashim Mitra; Fiscal Year: 2004
    ..of this study is to classify all anti-AIDS drugs, currently used clinically, under a new proposed Absorption-Metabolism Classification System (AMCS)...
  39. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    Keywords;Absorption;Distribution;Metabolism;Excretion;ADME;Metabolite identification;toxicokinetics;Mechanisms of toxicity;2,3-butanedione;diacetyl;N,N-dimethylacetoacetamide;obliterative bronchiolitis;CYP;eugenol;safrole;estragole;..
    Stephen M Beverley; Fiscal Year: 2010
    ..identified through the study of antifolate-resistant Leishmania parasites, which has lead us into studies of the metabolism of the unconjugated pteridine biopterin and the conjugated pteridine folate, and the development and application ..
    Dimitris Tatakis; Fiscal Year: 1991
    ..that leukotrienes (arachidonic acid metabolites derived from the lipoxygenase pathway) may also affect bone metabolism. However, there appears to be no information available about the possible role of lipoxins in bone physiology...
  42. Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT
    Donna Parker; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT Principal Investigator: Parker, Donna R...
  43. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The uptake and metabolism of ketone bodies in brain have been of interest to researchers and clinicians for decades but how they affect the coupling of blood flow and glucose metabolism, especially ..
  44. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ..This revision also serves to create new research objectives to explore the associations of nicotine metabolism and oxidative stress genetics outside of the scope of the parent grant, and will be completed in less than one ..
    Cynthia Morris; Fiscal Year: 1990
    The importance of maintaining dietary calcium intake and normal calcium metabolism for optimal regulation of arterial pressure in humans and experimental models has been demonstrated by us and other investigators...