t cell antigen receptor specificity

Summary

Summary: The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule.

Top Publications

  1. ncbi Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8+ T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ER
    Farah Aladin
    Division of Medical Microbiology, University of Liverpool, Daulby Street, Liverpool, UK
    Cancer Immunol Immunother 56:1143-52. 2007
  2. ncbi An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    J Immunol 178:1285-92. 2007
  3. pmc Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice
    Agnieszka Boesen
    Department of Microbiology and Immunology, City University of New York Medical School, New York, New York 10031, USA
    Clin Diagn Lab Immunol 12:1223-30. 2005
  4. pmc Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities
    Matthias Wolfl
    Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA
    Blood 110:201-10. 2007
  5. ncbi Mcl-1 and anticancer vaccination: identification of an HLA-A2-restricted epitope
    R S Andersen
    Leukemia 22:668-9. 2008
  6. pmc Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray
    Xujing Wang
    The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and The Children s Hospital Research Institute of Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 8:329. 2007
  7. ncbi Identification of an immunogenic EWS-FLI1-derived HLA-DR-restricted T helper cell epitope
    Friederike Meyer-Wentrup
    Department of Pediatrics, Children s Hospital Medical Center, Munich University of Technology, Munchen, Germany
    Pediatr Hematol Oncol 22:297-308. 2005
  8. ncbi Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic control
    K S K Tung
    Department of Pathology, Health Science Center, University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA
    Curr Top Microbiol Immunol 293:209-47. 2005
  9. ncbi Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection
    A Coutinho
    Laboratoire Européen Associé au CNRS, Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Curr Top Microbiol Immunol 293:43-71. 2005
  10. ncbi The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology
    C S Hsieh
    Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USA
    Curr Top Microbiol Immunol 293:25-42. 2005

Research Grants

  1. T CELLS IN GRANULOMATOUS IMMUNE RESPONSES
    Matyas Sandor; Fiscal Year: 2004
  2. Adoptive T Cell Therapy of Melanoma Targeting NY-ESO-1
    Cassian Yee; Fiscal Year: 2007
  3. Indirect recognition of microbes by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
  4. Antibody induced T cell mediated neonatal autoimmunity
    Kenneth Tung; Fiscal Year: 2007
  5. The role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2007
  6. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
  7. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
  8. In Situ Analysis of Hepatitis B virus-specific T cells
    Dorian McGavern; Fiscal Year: 2006
  9. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2006
  10. Role of DM in Generation of Immunodominant Epitope(s)
    Scheherazade Sadegh Nasseri; Fiscal Year: 2010

Detail Information

Publications129 found, 100 shown here

  1. ncbi Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8+ T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ER
    Farah Aladin
    Division of Medical Microbiology, University of Liverpool, Daulby Street, Liverpool, UK
    Cancer Immunol Immunother 56:1143-52. 2007
    ..Thus, for immunotherapeutic approaches to target SCLC and other tumours with defects in the MHC class I antigen processing pathway it will be important to consider strategies that address tapasin-defects...
  2. ncbi An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    J Immunol 178:1285-92. 2007
    ..These experiments provide insights that may be of value for adoptive immunotherapy, where careful consideration of both the activation state and the number of effector cells is required...
  3. pmc Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice
    Agnieszka Boesen
    Department of Microbiology and Immunology, City University of New York Medical School, New York, New York 10031, USA
    Clin Diagn Lab Immunol 12:1223-30. 2005
    ..These findings provide direct evidence for the existence of LV-derived GP epitopes that may be useful in the development of protective immunogens for this hemorrhagic virus...
  4. pmc Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities
    Matthias Wolfl
    Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA
    Blood 110:201-10. 2007
    ....
  5. ncbi Mcl-1 and anticancer vaccination: identification of an HLA-A2-restricted epitope
    R S Andersen
    Leukemia 22:668-9. 2008
  6. pmc Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray
    Xujing Wang
    The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and The Children s Hospital Research Institute of Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 8:329. 2007
    ..We have used the memory T cell repertoire to an influenza-derived peptide as a test case for developing such a method...
  7. ncbi Identification of an immunogenic EWS-FLI1-derived HLA-DR-restricted T helper cell epitope
    Friederike Meyer-Wentrup
    Department of Pediatrics, Children s Hospital Medical Center, Munich University of Technology, Munchen, Germany
    Pediatr Hematol Oncol 22:297-308. 2005
    ..The authors report the identification of the first EFT-specific immunogenic T-cell epitope so far. Its identification will lead to a better understanding of EFT immunology and may improve DC-based immunotherapy...
  8. ncbi Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic control
    K S K Tung
    Department of Pathology, Health Science Center, University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA
    Curr Top Microbiol Immunol 293:209-47. 2005
    ..The candidate genes include Pdcd1, TNFR superfamily genes, H2, Il2, Tgfb, Nalp5 or Mater, an oocyte autoAg that reacts with autoantibody in sera of d3tx mice...
  9. ncbi Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection
    A Coutinho
    Laboratoire Européen Associé au CNRS, Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Curr Top Microbiol Immunol 293:43-71. 2005
    ..1974) and in the system's evolution (Coutinho 1975, 1980) as well. After all, major transitions in evolution were cooperative (Maynard-Smith and Szathmary 1995)...
  10. ncbi The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology
    C S Hsieh
    Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USA
    Curr Top Microbiol Immunol 293:25-42. 2005
    ..Here, we will review the available evidence regarding naturally arising TR TCR specificity in the context of TR development, function, and homeostasis...
  11. ncbi The immunogenicity of dendritic cell-derived exosomes
    Ben J C Quah
    School of Biochemistry and Molecular Biology, Building 41, Linnaeus Way, Australian National University, Canberra, ACT 0200, Australia
    Blood Cells Mol Dis 35:94-110. 2005
    ..The possible function of immature DC and their exosomes in maintenance of tolerance and in the induction of immunity is discussed...
  12. ncbi Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus
    Louise Jones
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford, UK
    Eur J Immunol 37:3393-403. 2007
    ..In summary these data implicate persistent low-level or recurrent VZV antigen exposure in healthy immune donors and are compatible with a role for IE63-specific CD4+ T cells in the control of viral reactivation...
  13. ncbi Differential lysis of tumors by polyclonal T cell lines and T cell clones specific for hTERT
    Dih Yih Chen
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 6:1991-6. 2007
    ..Thus, I540-specific T cells can vary in cytotoxic potential depending on the method of generation, isolation and expansion...
  14. ncbi Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    Jie Yu
    Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Med Virol 78:1147-57. 2006
    ..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
  15. ncbi Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patients
    Tomohiro Kozako
    Division of Host Response, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Immunol 177:5718-26. 2006
    ..These results suggest that decreased frequency, diversity, and function of anti-HTLV-1 Tax CD8+ T cell clones may be one of the risks of ATL development...
  16. pmc Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberation
    Yoshinori Ito
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Virol 80:883-90. 2006
    ....
  17. ncbi Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor
    Stefan Gattenlohner
    Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany
    Cancer Res 66:24-8. 2006
    ....
  18. pmc Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
    Joseph P Casazza
    Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2865-77. 2006
    ..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes...
  19. ncbi Assessment of CD4+ T cells specific for the tumor antigen SSX-1 in cancer-free individuals
    Emmanuelle Godefroy
    Ludwig Institute Clinical Trial Center, Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Immunol Immunother 56:1183-92. 2007
    ....
  20. ncbi H2-M3-restricted T cells participate in the priming of antigen-specific CD4+ T cells
    Michael T Chow
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 177:5098-104. 2006
    ..These results reveal a novel function for H2-M3- and Qa-1-restricted T cells; provision of help to CD4+ Th cells during the primary response...
  21. ncbi Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo
    Christopher Chiu
    Department of Immunology, Wright Fleming Institute, Imperial College, London, and John Radcliffe Hospital, Oxford, UK
    Blood 109:1086-94. 2007
    ..However, T-cell proliferation was not observed until 48 hours. We therefore conclude that clonal expansion rather than acquisition of effector function is the rate-limiting step in the development of a primary CTL response...
  22. ncbi Impact of Gag sequence variability on level, phenotype, and function of anti-HIV Gag-specific CD8(+) cytotoxic T lymphocytes in untreated chronically HIV-infected patients
    Mariola Lopez
    Infectious Diseases and Haematology Unit, Hospital Carlos III, 28029 Madrid, Spain
    AIDS Res Hum Retroviruses 22:884-92. 2006
    ..These results suggest that viral mutations driven by immune selection pressure may play an important role in evading the immunological response in chronically HIV-infected individuals...
  23. ncbi Identification of novel foot-and-mouth disease virus specific T-cell epitopes in c/c and d/d haplotype miniature swine
    Wilhelm Gerner
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey, UK
    Virus Res 121:223-8. 2006
    ..This is the first report on FMDV specific T-cell epitopes recognized by swine leukocyte antigen (SLA) inbred swine and provides information useful for the design of novel vaccines against FMDV...
  24. ncbi Virus-specific T-cell responses associated with hepatitis C virus (HCV) persistence in the liver after apparent recovery from HCV infection
    Juan A Quiroga
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 78:1190-7. 2006
    ....
  25. ncbi CD28 and CD27 costimulation of CD8+ T cells: a story of survival
    Douglas V Dolfi
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Adv Exp Med Biol 590:149-70. 2007
    ....
  26. ncbi CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells
    Alexandre Corthay
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Adv Exp Med Biol 590:195-208. 2007
  27. ncbi Immunological changes and cytokine gene expression during primary infection with human T-cell leukaemia virus type 1 in squirrel monkeys (Saimiri sciureus)
    Jean Michel Heraud
    Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, BP6010, 97306 Cayenne, French Guiana, France
    Virology 361:402-11. 2007
    ..Further studies will be needed to determine the effective role of these cytokines and other immune system modulators in the control of viral replication during primary HTLV-1 infection or latency...
  28. ncbi Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate
    Hirokuni Kitamei
    Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    J Leukoc Biol 79:1193-201. 2006
    ..Regulation of NF-kappaB pathway in the lesion could be a novel target for the successful control of uveoretinitis...
  29. pmc Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C
    Tobias Manigold
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4424-32. 2006
    ..This result suggests that HCV infection alters the population of Foxp3(+)CD4(+)CD25(+) T(Reg) cells...
  30. ncbi Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancer
    Michael J Anderson
    Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, National Cancer Institute, National Institutes of Health, Frederick, MD 21701, USA
    J Immunol 178:1268-76. 2007
    ....
  31. pmc Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells
    Eddie W Adams
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immununology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Chembiochem 9:294-303. 2008
    ..Taken together, our data suggest that a DC targeting strategy that is based upon carbohydrate-lectin interactions is a promising approach for enhancing antigen presentation via class I and class II molecules...
  32. ncbi Uptake and presentation of hepatitis C virus-like particles by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Blood 105:3605-14. 2005
    ..Furthermore, HCV-LP-mediated DC activation and efficient antigen presentation may explain the marked immunogenicity of HCV-LPs in vivo...
  33. ncbi Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection
    Ester M M van Leeuwen
    Department of Internal Medicine, and Laboratory of for Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 173:1834-41. 2004
    ..Thus, CD4(+)CD28(-) T cells emerge as a consequence of CMV infection...
  34. doi Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Immunother 31:199-206. 2008
    ..Adoptive T-cell transfer could potentially restore T-cell immunity against adenovirus after allogeneic stem cell transplantation...
  35. ncbi Regulatory T cells and organ transplantation
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
    Semin Immunol 16:119-26. 2004
    ..The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination...
  36. ncbi Antigen-specific regulatory T cells--their induction and role in infection
    Kingston H G Mills
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Semin Immunol 16:107-17. 2004
    ..Tr1 or Th3 cells are capable of suppressing Th1 and Th2 responses and function in infection to limit pathogen-induced immunopathology, but can also be exploited in therapies for immune-mediated diseases...
  37. pmc T-cell promiscuity in autoimmune diabetes
    Li Li
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 57:2099-106. 2008
    ..Nevertheless, the molecular basis for recognition of beta-cell-specific epitopes by pathogenic T-cells remains ill defined; we seek to further explore this issue...
  38. ncbi Detection of antigen-specific T cells in experimental immune-mediated blepharoconjunctivitis in DO11.10 T cell receptor transgenic mice
    Akemi Ozaki
    Laboratory of Immunology, Department of Ophthalmology, Kochi Medical School, Japan
    Microbiol Immunol 48:39-48. 2004
    ..The challenge of OVA peptide 323-339 induced EC in DO11.10 TcR-Tg mice without prior sensitization. The response was mediated by CD4(+) Ag-specific T cells. The trafficking of Ag-specific T cells in EC was clearly visualized...
  39. doi Immune responses during acute and chronic infection with hepatitis C virus
    Shigeaki Ishii
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Clin Immunol 128:133-47. 2008
    ..Resolution of these outstanding questions is important to the development of a prophylactic vaccine as well as improving therapeutic options for those with chronic infection...
  40. ncbi Identification of an HLA-A*02 restricted immunogenic peptide derived from the cancer testis antigen HOM-MEL-40/SSX2
    Claudia Wagner
    Med Klinik I, Saarland University Medical School, D 66424 Homburg, Germany
    Cancer Immun 3:18. 2003
    ..p103-111 holds promise as a broadly applicable peptide vaccine for patients with HOM-MEL-40/SSX2 positive neoplasms...
  41. pmc CD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naïve and antigen-primed T cells
    Kapilan Kugathasan
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    BMC Immunol 9:48. 2008
    ....
  42. pmc Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice
    Kazuyuki Kawamura
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249
    J Immunol 181:3202-11. 2008
    ....
  43. doi Identification of human antigen-specific T cells using MHC class I and class II tetramers
    Lori A Krueger
    Beckman Coulter Inc, San Diego, California, USA
    Curr Protoc Cytom . 2004
    ..To minimize nonspecific tetramer binding contributed by irrelevant cell populations, a cumulative gating strategy using positive selection and/or exclusion gating is described...
  44. ncbi B cell lipid rafts regulate both peptide-dependent and peptide-independent APC-T cell interaction
    Niclas Setterblad
    Institut National de la Sante et de la Recherche Medicale Unite 396, Institut Universitaire d Hematologie, Hopital St Louis, Paris, France
    J Immunol 173:1876-86. 2004
    ..Such peptide-independent conjugates did not retain the ability to activate T cells. Thus, B cell lipid rafts are bifunctional by regulating T cell activation and imposing peptide stringency...
  45. ncbi Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR
    Jürgen Kuball
    Department of Hematology and Oncology, Johannes Gutenberg University, 55101 Mainz, Germany
    Immunity 22:117-29. 2005
    ..The intentional redirection of both CD4+ Th cells and CD8+ CTL by the same high-affinity, CD8-independent, tumor-specific TCR could provide the basis for novel broad-spectrum cancer immunotherapeutics...
  46. ncbi Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma
    Carmen Choi
    Tumor Immunology Program, The German Cancer Research Center, INF 280, 69 120 Heidelberg, Germany
    Blood 105:2132-4. 2005
    ..BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon gamma (IFN-gamma) secretion, perforin production, and cytotoxicity...
  47. ncbi Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes
    Divya J Mekala
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, D 4047, Memphis, TN 38105, USA
    Blood 105:2090-2. 2005
    ..These results provide proof of principal for a novel approach to enforce the interaction of regulatory and pathologic T lymphocytes, thereby facilitating the treatment of autoimmune disease...
  48. pmc Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cells
    Yi Zeng
    University of Arizona, Department of Pediatrics, Steele Memorial Children s Center, 1501 N Campbell Ave, PO Box 245073, Tucson, AZ 85724 5073, USA
    Blood 105:2016-22. 2005
    ....
  49. doi Long-term phenotypic, functional and genetic stability of cancer-specific T-cell receptor (TCR) alphabeta genes transduced to CD8+ T cells
    A Hiasa
    Department of Immuno Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan
    Gene Ther 15:695-9. 2008
    ..Our results indicate that TCR-transduced alphabeta T cells by retroviral transduction represent an efficient and promising strategy for adoptive T-cell transfer for long term...
  50. pmc Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection
    Christopher C Kemball
    Molecular and Integrative Neurosciences Dept, SP30 2110, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 82:4331-42. 2008
    ..Finally, our findings have implications for the biological significance of cross-priming, a process thought by some to be important for the induction of antiviral CD8(+) T-cell responses...
  51. ncbi Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele
    Guido Ferrari
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 173:2126-33. 2004
    ....
  52. doi T-cell allorecognition: a case of mistaken identity or déjà vu?
    Julia K Archbold
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Trends Immunol 29:220-6. 2008
    ....
  53. ncbi Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 173:1966-77. 2004
    ....
  54. pmc Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections
    L K Selin
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA
    J Exp Med 183:2489-99. 1996
    ..This demonstrates that virus infections do not occur in immunological isolation, and that CD8+ T cell responses are continually being modulated by other infectious agents...
  55. doi Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Neurosci 29:15397-409. 2009
    ..Thus, electrical silencing is an immediate consequence of MHC I-restricted interaction of CD8(+) T cells with neurons. This mechanism is clearly perforin-dependent and precedes, but is not causally linked, to neuronal cell death...
  56. ncbi Coreceptor CD8-driven modulation of T cell antigen receptor specificity
    Hugo A van den Berg
    Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 249:395-408. 2007
    ..The functional diversity of the TCR repertoire would therefore be greatly augmented by coreceptor-mediated ligand focussing...
  57. doi Bispecific T-cell engaging antibodies for cancer therapy
    Patrick A Baeuerle
    Micromet Inc, Bethesda, Maryland, USA
    Cancer Res 69:4941-4. 2009
    ..Recent results from clinical studies with a CD19/CD3-bispecific BiTE antibody suggest that this therapeutic paradigm is finally showing promise for treatment of both bulky and minimal residual disease...
  58. ncbi A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity
    E M Schad
    Department of Molecular Biophysics, Center for Chemistry and Chemical Engineering, Lund University, Sweden
    J Mol Biol 269:270-80. 1997
    ..A common Zn2(+)-binding site was identified in both staphylococcal enterotoxin A and C2 that is superimposable but differs somewhat in its coordination geometry between the two molecules...
  59. pmc Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells
    Remy Bosselut
    Laboratory of Immune Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 197:1709-19. 2003
    ..These results challenge classical concepts of lineage commitment but fulfill predictions of the kinetic signaling model...
  60. pmc Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability
    Scott R Burrows
    Cellular Immunology Laboratory, Queensland Institute of Medical Research and Australian Centre for Vaccine Development, Brisbane 4029, Australia
    Proc Natl Acad Sci U S A 107:10608-13. 2010
    ..Collectively, our findings reveal the inherent adaptability of the TCR in maintaining peptide recognition while accommodating changes to the central docking site on the pMHC-I...
  61. pmc T cell receptor specificity for major histocompatibility complex proteins
    Philippa Marrack
    Howard Hughes Medical Institute, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Immunol 20:203-7. 2008
    ..These amino acids may therefore have been selected evolutionarily to predispose T cell receptors toward recognition of MHC ligands...
  62. ncbi The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    Xiao He
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Nature 433:826-33. 2005
    ....
  63. ncbi CD4-CD8 lineage commitment: an inside view
    Dietmar J Kappes
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Nat Immunol 6:761-6. 2005
    ..Finally, identification of the transcription factor Th-POK as a central component of the CD4 lineage-determining pathway has provided a new starting point from which to unravel this intriguing process 'from the inside out'...
  64. ncbi Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    Z X Zhang
    Department of Laboratory of Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada
    Nat Med 6:782-9. 2000
    ..These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression...
  65. doi Activated T cells recruit exosomes secreted by dendritic cells via LFA-1
    Esther N M Nolte-'t Hoen
    Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, Utrecht, The Netherlands
    Blood 113:1977-81. 2009
    ..These results imply that DC exosomes secreted in the extracellular milieu during cognate T-cell-DC interactions are targeted to T cells activated in that microenvironment...
  66. doi Kickstarting Foxp3 with c-Rel
    Chyi Song Hsieh
    Department of Internal Medicine, Division of Rheumatology, Washington University, Saint Louis, MO 63110, USA
    Immunity 31:852-3. 2009
    ..2009) and Ruan et al. (2009) suggest that the transcription factor NF-kappaB-c-Rel is an important molecular mechanism by which T cell receptor-specificity for self-antigens instructs the selection of Foxp3(+) regulatory T cells...
  67. ncbi Clinical experience with gene therapy and bispecific antibodies for T cell-based therapy of cancer
    Patrick A Baeuerle
    MGEN Research Munich GmbH, Munich, Germany
    Curr Pharm Biotechnol 13:1399-408. 2012
    ..Initial experience has recently been gained in the clinic with both technologies such that their fundamental differences can now be discussed on the basis of patient data...
  68. ncbi Increased induction of allogeneic-specific cord blood CD4+CD25+ regulatory T (Treg) cells: a comparative study of naïve and antigenic-specific cord blood Treg cells
    Chih Chao Chang
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Exp Hematol 33:1508-20. 2005
    ..In this study, we investigated if cord blood (CB) CD4(+)CD25(+) T cells play a significant role in reducing the immune responses of allo-reactive CD4(+)CD25(-) T lymphocytes...
  69. doi Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 33:42-9. 2009
    ....
  70. doi Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
    Ed Palmer
    Department of Nephrology and Biomedicine, Laboratory of Transplantation Immunology, University Hospital Basel, Basel, Switzerland
    Nat Rev Immunol 9:207-13. 2009
    ....
  71. doi Benefits and burden of the maternally-mediated immunological imprinting
    Hilmar Lemke
    Biochemical Institute of the Medical Faculty of the Christian Albrechts University at Kiel, Germany
    Autoimmun Rev 8:394-9. 2009
    ..Hence, immunological imprinting by maternal IgG antibodies will mostly be beneficial, but in case of autoantibodies can also be a burden for the initial development of the nascent immune system...
  72. pmc The specificity of T cell regulation that enables self-nonself discrimination in the periphery
    Yilun Wu
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:534-9. 2009
    ....
  73. ncbi Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clones
    Kenji Yoshida
    Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita 565 0871, Japan
    Int Immunol 14:1439-47. 2002
    ..The results suggest that our islet-reactive T cell clones recognize in islet beta cells a natural ligand that is similar to these peptides...
  74. ncbi Impact of antigen-unloaded immature dendritic cells on antileukemic T-cell cytotoxicity
    Ulf Harnack
    Medical Clinic of Oncology and Hematology, Charite Universitatsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany
    Anticancer Res 28:2831-5. 2008
    ..Immature dendritic cells (iDC) loaded with antigens are able to induce tolerance in antigen-specific T-cells. The potential of antigen-unloaded iDC to regulate the antileukemic cytotoxicity of autologous T-cells was determined...
  75. doi High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function
    Peter Nickel
    Department of Nephrology and Intensive Care, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Transpl Immunol 20:238-42. 2009
    ..The aim of this study was to define the relation of CMV-specific T-cell responses to acute rejection, donor-reactive memory T cells, and allograft function after kidney transplantation...
  76. pmc How the thymus designs antigen-specific and self-tolerant T cell receptor sequences
    Andrej Kosmrlj
    Departments of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:16671-6. 2008
    ..A dominant role for negative selection in mediating antigen specificity of mature T cells and a molecular mechanism for TCR recognition of antigen are described...
  77. ncbi TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model
    Michele Fiscella
    Department of Preclinical Discovery, Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Nat Biotechnol 21:302-7. 2003
    ..Therefore, combining functional genomics with high-throughput cell-based screening is a valuable and efficient approach to identifying immunomodulatory activities for novel proteins...
  78. ncbi Immunoregulation in the tissues by gammadelta T cells
    Adrian Hayday
    Peter Gorer Department of Immunobiology, Guy s, King s and StThomas Medical School, King s College, London SE1 9RT, UK
    Nat Rev Immunol 3:233-42. 2003
    ..In this article, we look at immunoregulatory gammadelta T cells, and the growing evidence for tissue-associated immunoregulation mediated by both gammadelta T cells and alphabeta T cells...
  79. ncbi What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?
    Dominique Housset
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale J P Ebel, CEA CNRS UJF, 41 rue Jules Horowitz, F 38027 Grenoble Cedex 1, France
    Trends Immunol 24:429-37. 2003
  80. doi Minor role of bystander tolerance to fetal calf serum in a peptide-specific dendritic cell vaccine model against autoimmunity: comparison with serum-free cultures
    Susanne Röner
    Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    J Immunother 31:656-64. 2008
    ..Together, our data show that presentation of bystander antigens by peptide-specific DC vaccinations may have little influence on T-cell responses in vivo if the bystander antigen cannot be recalled by specific T cells...
  81. pmc NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain
    Chandra Deb
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurovirol 14:261-6. 2008
    ....
  82. doi IL-7 adjuvant treatment enhances long-term tumor-antigen-specific CD8+ T-cell responses after immunization with recombinant lentivector
    Sara Colombetti
    Ludwig Institute for Cancer Research Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, Epalinges, Switzerland
    Blood 113:6629-37. 2009
    ..Altogether, these data show that IL-7 adjuvant treatment can enhance long-term antigen-specific CD8+ T-cell responses. However, its efficacy depends on the expression of IL-7Ralpha at the surface of effector CD8+ T cells...
  83. ncbi TCR specificity dictates CD94/NKG2A expression by human CTL
    Bana Jabri
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Immunity 17:487-99. 2002
    ..These findings suggest that TCR antigenic specificity dictates NKG2A commitment, which critically regulates subsequent activation of CTL...
  84. doi Experimental autoimmune encephalomyelitis in the rat
    Mark Mannie
    Department of Microbiology and Immunology, East Carolina University, Brody School of Medicine, Greenville, North Carolina, USA
    Curr Protoc Immunol . 2009
    ..This unit also provides a brief discussion of the basic characteristics of these models...
  85. doi T-cell receptor specificity of CD8(+) Tregs in allotransplantation
    Elodie Picarda
    INSERM U643, Nantes, F44000, France
    Immunotherapy 3:35-7. 2011
    ..Identification of the antigenic targets and TCR repertoire of CD8(+) Tregs will allow a better understanding of their recognition properties and will highlight the potential of such of specific population in cell-based treatment...
  86. pmc Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection
    William W Reiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 107:19408-13. 2010
    ..Our findings suggest that antigen-specific T-cell responses are maintained during chronic mycobacterial infection through the continual production of terminal effector cells from a proliferating precursor population...
  87. pmc TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
    Rachel A Gottschalk
    Department of Immunology, Howard Hughes Medical Institute, New York, NY 10021, USA
    J Exp Med 207:1701-11. 2010
    ..However, in the persistence of induced Foxp3(+) T cells, TCR ligand potency and density are noninterchangeable factors that influence the route to peripheral tolerance...
  88. doi Kinetics of cytomegalovirus (CMV) pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells during episodes of viral DNAemia in allogeneic stem cell transplant recipients: potential implications for the management of active CMV infection
    Nuria Tormo
    Microbiology Service, Clinic University Hospital, Valencia, Spain
    J Med Virol 82:1208-15. 2010
    ..Data obtained in the present study may be helpful in the design of therapeutic strategies for the management of active CMV infections in the allo-SCT recipient...
  89. ncbi CD3+CD4-CD8- alphabeta-TCR+ T cell as immune regulatory cell
    Z X Zhang
    Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, 101 College Street, CCRW2 815, Toronto, M5A 1E7, Canada
    J Mol Med (Berl) 79:419-27. 2001
    ....
  90. doi Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques
    Maximillian Rosario
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford, UK
    Eur J Immunol 40:1973-84. 2010
    ..Thus, by improving both the HIV-1-derived immunogen and vector regimen/delivery, this approach could induce stronger, broader, and theoretically more protective T-cell responses than vaccines previously used in humans...
  91. doi Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection
    Aleksandra Leligdowicz
    Weatherall Institute of Molecular Medicine, Medical Research Council Human Immunology Unit, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 40:1963-72. 2010
    ..We propose that in chronic HIV-2 infection, the maintenance of early-differentiated, highly avid CD8(+) T cells could account for the non-progressive course of disease. Such responses may be desirable from an HIV vaccine...
  92. pmc Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization
    Maytal Bivas-Benita
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 84:5764-74. 2010
    ..These findings suggest that pulmonary PEI-DNA immunization might be a useful approach for immunizing against pulmonary pathogens and might also protect against infections initiated at other mucosal sites...
  93. ncbi NKT cells derive from double-positive thymocytes that are positively selected by CD1d
    L Gapin
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Nat Immunol 2:971-8. 2001
    ..models propose that NKT cells branch off the mainstream developmental pathway because of their T cell antigen receptor specificity, whereas stochastic models would propose that they develop from precursor cells committed to this ..
  94. doi Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells
    Simone Cuff
    Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:607-14. 2010
    ..These data provide a rationale for previously unexplained data identifying contrasting roles for CD8+ T cells in tumor progression...
  95. ncbi Oligoclonal accumulations of T-cell clones in gingivitis and periodontitis lesions
    H Itoh
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Microbiol Immunol 17:324-9. 2002
    ..It remains to be determined, however, what role these antigen-specific T cells play and what antigens the T cells recognize in the pathogenesis of periodontal disease...
  96. doi Antigen recognition by CD1d-restricted NKT T cell receptors
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Grattan St, Parkville, Victoria 3010, Australia
    Semin Immunol 22:61-7. 2010
    ....
  97. doi Alloantigen specific T regulatory cells in transplant tolerance
    Bruce M Hall
    Department of Medicine, The University of New South Wales, Liverpool Hospital, Liverpool, NSW, Australia
    Int Immunopharmacol 9:570-4. 2009
    ..These findings suggest that Th1 and Th2 responses activate two pathways of alloantigen specific Tregs that can mediate transplant tolerance but are dependent upon cytokines produced by ongoing Th1 and/or Th2 immune responses...
  98. ncbi Distinguishing the tritope from the interaction antigen models
    Melvin Cohn
    Trends Immunol 25:8-9; author reply 9-10. 2004
  99. ncbi Molecular aspects of regulatory T cell development
    Jason D Fontenot
    Howard Hughes Medical Institute, Box 357370, Health Science Bldg I604I, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Semin Immunol 16:73-80. 2004
    ..This review highlights the major molecular pathways that have been implicated to date in the development of this T cell lineage...
  100. ncbi Evaluation of intervention strategy based on CMV-specific immune responses after allogeneic SCT
    G Avetisyan
    Division of Haematology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Bone Marrow Transplant 40:865-9. 2007
    ..01). There was no effect as regards the type of conditioning, donor type, stem cell source or acute GVHD. Monitoring the immunity of SCT patients may allow more targeted use of antiviral therapy...
  101. pmc Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens
    Sjoerd H van der Burg
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 104:12087-92. 2007
    ..Our findings offer a plausible explanation for the observed failure of the tumor-specific immune response in patients with cervical carcinoma...

Research Grants93

  1. T CELLS IN GRANULOMATOUS IMMUNE RESPONSES
    Matyas Sandor; Fiscal Year: 2004
    ..abstract_text> ..
  2. Adoptive T Cell Therapy of Melanoma Targeting NY-ESO-1
    Cassian Yee; Fiscal Year: 2007
    ..abstract_text> ..
  3. Indirect recognition of microbes by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
    ....
  4. Antibody induced T cell mediated neonatal autoimmunity
    Kenneth Tung; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Nurnbet_ Face Page .................................................................................................................................................. 1 Description, ..
  5. The role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2007
    ..The experimental results derived from the proposed experiments could provide important insights into the mechanisms for the beneficial and potentially harmful effects of such a blockade. ..
  6. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
    ....
  7. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
    ..Compare peptide repertoires of DO-/-, DM-/- and WT thymic stromal cells 3b. Generate mice expressing a DR1 mutant (DRbG86Y) that participates in short-lived complexes and study thymocyte selection. ..
  8. In Situ Analysis of Hepatitis B virus-specific T cells
    Dorian McGavern; Fiscal Year: 2006
    ..The main objective of this research is to more precisely define the contribution of HBV-specific CTL to viral clearance and pathogenesis by providing the first comprehensive analysis of these cells in situ. ..
  9. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2006
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  10. Role of DM in Generation of Immunodominant Epitope(s)
    Scheherazade Sadegh Nasseri; Fiscal Year: 2010
    ..This research has great impacts on discovering immunodominant epitopes of infectious agents relevant to biodefense. ..
  11. Indirect recognition of microbes by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..
  12. Antibody induced T cell-mediated neonatal autoimmunity.
    Kenneth S K Tung; Fiscal Year: 2010
    ....
  13. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..
  14. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2009
    ..Understanding how the immune system supports hematopoiesis is needed to develop strategies for the prevention and treatment of pancytopenia in AIDS patients. ..
  15. IEL and NKG2 Receptors in Celiac Disease
    Bana Jabri; Fiscal Year: 2009
    ..Collectively, these studies will dissect the fine regulation of human effector CTLs in a diseased intestinal epithelium by a novel ligand/receptor system linking innate and adaptive immunity. ..
  16. Zona Pellucida - Immunopathological Study
    Kenneth Tung; Fiscal Year: 2009
    ..By exploiting appropriate autoimmune disease models, we aim to elucidate important cellular mechanisms whereby the autoimmune process is normally controlled, and how clinical autoimmunity is induced. ..
  17. Development of a Universal Influenza Seasonal Vaccine
    David B Weiner; Fiscal Year: 2010
    ..comprising immunologically relevant, highly conserved viral components would be more cost-effective than purifying vaccine from viral culture in chicken eggs and potentially more broadly effective than the traditional methodology ..
  18. Zona Pellucida - Immunopathological Study
    Kenneth S K Tung; Fiscal Year: 2010
    ..By exploiting appropriate autoimmune disease models, we aim to elucidate important cellular mechanisms whereby the autoimmune process is normally controlled, and how clinical autoimmunity is induced. ..
  19. Integrative genomics to to dissect the genetic regulation of T1D onset
    Xujing Wang; Fiscal Year: 2007
    ..The management of T1D is difficult particularly in the young, and in recent decades incidence in the young is rising rapidly. ..
  20. T Cell Immunity & Liver Fibrosis in HCV/HIV Coinfection
    Chihiro Morishima; Fiscal Year: 2003
    ..Finally, we will test the hypotheses that HCV/HIV coinfected subjects treated with HAART will demonstrate improved HCV-specific CD4+ T cell function that is not fibrogenic, and is sequestered to the liver. ..
  21. ANTIGEN PRESENTATION BY CD1 MOLECULES
    Mitchell Kronenberg; Fiscal Year: 2000
    ....
  22. ZONA PELLUCIDA--IMMUNOPATHOLOGIC STUDY
    Kenneth Tung; Fiscal Year: 1999
    ....
  23. ZONA PELLUCIDA--IMMUNOPATHOLOGIC STUDY
    Kenneth Tung; Fiscal Year: 2004
    ..abstract_text> ..
  24. ANTIGEN PRESENTING FUNCTION OF THE TL AND CD1 MOLECULES
    Mitchell Kronenberg; Fiscal Year: 1999
    ....
  25. Antibody induced T cell mediated neonatal autoimmunity
    Kenneth Tung; Fiscal Year: 2003
    ..This proposal will therefore address fundamental mechanisms responsible for autoimmune induction and prevention, and specifically, neonatal autoimmune diseases including systemic lupus-related congenital heart block. ..
  26. Regulation of Human IELs by CD94 and HLA-E
    Bana Jabri; Fiscal Year: 2005
    ....
  27. T cell Interactions in the CNS During Viral Persistence
    Dorian McGavern; Fiscal Year: 2005
    ..The main objective of this research is to define the immunologic parameters that contribute to viral clearance versus persistence in the CNS and foster approaches that tip the balance in favor of clearance. ..
  28. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
    ..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
  29. MOLECULAR BASIS FOR NK T CELL RECOGNITION AND FUNCTION
    Mitchell Kronenberg; Fiscal Year: 2004
    ..abstract_text> ..
  30. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2004
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  31. NKT Cell Recognition of Streptococcus Pneumoniae
    Mitchell Kronenberg; Fiscal Year: 2007
    ..The results from these studies should help in understanding iNKT cell biology and the response to S. pneumoniae, which could lead to the development of more effective vaccines against this organism. ..
  32. Regulation of normal human IEL by NKG2D and IL-15
    Bana Jabri; Fiscal Year: 2007
    ....
  33. Poly-functional analyses of vaccine-induced T cell responses
    Guido Ferrari; Fiscal Year: 2007
    ..Overall, these findings will shed new insights on the importance and fate of vaccine-induced T cell responses in controlling HIV-infection. ..
  34. Antibody induced T cell mediated neonatal autoimmunity
    Kenneth Tung; Fiscal Year: 2006
    ..This proposal will therefore address fundamental mechanisms responsible for autoimmune induction and prevention, and specifically, neonatal autoimmune diseases including systemic lupus-related congenital heart block. ..