Genomes and Genes
t cell antigen receptor specificity
Summary: The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule.
Publications167 found, 100 shown here
- Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturationJoseph P Casazza
Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 203:2865-77. 2006..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes...
- Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infectionChristopher C Kemball
Molecular and Integrative Neurosciences Dept, SP30 2110, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
J Virol 82:4331-42. 2008..Finally, our findings have implications for the biological significance of cross-priming, a process thought by some to be important for the induction of antiviral CD8(+) T-cell responses...
- Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis CTobias Manigold
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 107:4424-32. 2006..This result suggests that HCV infection alters the population of Foxp3(+)CD4(+)CD25(+) T(Reg) cells...
- Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCRJürgen Kuball
Department of Hematology and Oncology, Johannes Gutenberg University, 55101 Mainz, Germany
Immunity 22:117-29. 2005..The intentional redirection of both CD4+ Th cells and CD8+ CTL by the same high-affinity, CD8-independent, tumor-specific TCR could provide the basis for novel broad-spectrum cancer immunotherapeutics...
- Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantationTobias Feuchtinger
Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
J Immunother 31:199-206. 2008..Adoptive T-cell transfer could potentially restore T-cell immunity against adenovirus after allogeneic stem cell transplantation...
- T-cell promiscuity in autoimmune diabetesLi Li
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Diabetes 57:2099-106. 2008..Nevertheless, the molecular basis for recognition of beta-cell-specific epitopes by pathogenic T-cells remains ill defined; we seek to further explore this issue...
- Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myelomaCarmen Choi
Tumor Immunology Program, The German Cancer Research Center, INF 280, 69 120 Heidelberg, Germany
Blood 105:2132-4. 2005..BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon gamma (IFN-gamma) secretion, perforin production, and cytotoxicity...
- Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytesDivya J Mekala
Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, D 4047, Memphis, TN 38105, USA
Blood 105:2090-2. 2005..These results provide proof of principal for a novel approach to enforce the interaction of regulatory and pathologic T lymphocytes, thereby facilitating the treatment of autoimmune disease...
- CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cellsAlexandre Corthay
Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
Adv Exp Med Biol 590:195-208. 2007
- Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cellsYi Zeng
University of Arizona, Department of Pediatrics, Steele Memorial Children s Center, 1501 N Campbell Ave, PO Box 245073, Tucson, AZ 85724 5073, USA
Blood 105:2016-22. 2005....
- Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cellsEddie W Adams
Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immununology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
Chembiochem 9:294-303. 2008..Taken together, our data suggest that a DC targeting strategy that is based upon carbohydrate-lectin interactions is a promising approach for enhancing antigen presentation via class I and class II molecules...
- Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic miceKazuyuki Kawamura
Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249
J Immunol 181:3202-11. 2008....
- Immunological changes and cytokine gene expression during primary infection with human T-cell leukaemia virus type 1 in squirrel monkeys (Saimiri sciureus)Jean Michel Heraud
Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, BP6010, 97306 Cayenne, French Guiana, France
Virology 361:402-11. 2007..Further studies will be needed to determine the effective role of these cytokines and other immune system modulators in the control of viral replication during primary HTLV-1 infection or latency...
- The immunogenicity of dendritic cell-derived exosomesBen J C Quah
School of Biochemistry and Molecular Biology, Building 41, Linnaeus Way, Australian National University, Canberra, ACT 0200, Australia
Blood Cells Mol Dis 35:94-110. 2005..The possible function of immature DC and their exosomes in maintenance of tolerance and in the induction of immunity is discussed...
- The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biologyC S Hsieh
Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USA
Curr Top Microbiol Immunol 293:25-42. 2005..Here, we will review the available evidence regarding naturally arising TR TCR specificity in the context of TR development, function, and homeostasis...
- Mcl-1 and anticancer vaccination: identification of an HLA-A2-restricted epitopeR S Andersen
Leukemia 22:668-9. 2008
- Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarrayXujing Wang
The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and The Children s Hospital Research Institute of Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
BMC Genomics 8:329. 2007..We have used the memory T cell repertoire to an influenza-derived peptide as a test case for developing such a method...
- Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberationYoshinori Ito
Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
J Virol 80:883-90. 2006....
- Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic miceAgnieszka Boesen
Department of Microbiology and Immunology, City University of New York Medical School, New York, New York 10031, USA
Clin Diagn Lab Immunol 12:1223-30. 2005..These findings provide direct evidence for the existence of LV-derived GP epitopes that may be useful in the development of protective immunogens for this hemorrhagic virus...
- Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virusLouise Jones
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford, UK
Eur J Immunol 37:3393-403. 2007..In summary these data implicate persistent low-level or recurrent VZV antigen exposure in healthy immune donors and are compatible with a role for IE63-specific CD4+ T cells in the control of viral reactivation...
- Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptorStefan Gattenlohner
Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany
Cancer Res 66:24-8. 2006....
- Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancerMichael J Anderson
Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, National Cancer Institute, National Institutes of Health, Frederick, MD 21701, USA
J Immunol 178:1268-76. 2007....
- Long-term phenotypic, functional and genetic stability of cancer-specific T-cell receptor (TCR) alphabeta genes transduced to CD8+ T cellsA Hiasa
Department of Immuno Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan
Gene Ther 15:695-9. 2008..Our results indicate that TCR-transduced alphabeta T cells by retroviral transduction represent an efficient and promising strategy for adoptive T-cell transfer for long term...
- Identification of an immunogenic EWS-FLI1-derived HLA-DR-restricted T helper cell epitopeFriederike Meyer-Wentrup
Department of Pediatrics, Children s Hospital Medical Center, Munich University of Technology, Munchen, Germany
Pediatr Hematol Oncol 22:297-308. 2005..The authors report the identification of the first EFT-specific immunogenic T-cell epitope so far. Its identification will lead to a better understanding of EFT immunology and may improve DC-based immunotherapy...
- Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic controlK S K Tung
Department of Pathology, Health Science Center, University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA
Curr Top Microbiol Immunol 293:209-47. 2005..The candidate genes include Pdcd1, TNFR superfamily genes, H2, Il2, Tgfb, Nalp5 or Mater, an oocyte autoAg that reacts with autoantibody in sera of d3tx mice...
- Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selectionA Coutinho
Laboratoire Européen Associé au CNRS, Instituto Gulbenkian de Ciencia, Oeiras, Portugal
Curr Top Microbiol Immunol 293:43-71. 2005..1974) and in the system's evolution (Coutinho 1975, 1980) as well. After all, major transitions in evolution were cooperative (Maynard-Smith and Szathmary 1995)...
- Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 alleleGuido Ferrari
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 173:2126-33. 2004....
- Identification of human antigen-specific T cells using MHC class I and class II tetramersLori A Krueger
Beckman Coulter Inc, San Diego, California, USA
Curr Protoc Cytom . 2004..To minimize nonspecific tetramer binding contributed by irrelevant cell populations, a cumulative gating strategy using positive selection and/or exclusion gating is described...
- Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA allelesHomayoun Shams
Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
J Immunol 173:1966-77. 2004....
- T-cell allorecognition: a case of mistaken identity or déjà vu?Julia K Archbold
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
Trends Immunol 29:220-6. 2008....
- Identification of an HLA-A*02 restricted immunogenic peptide derived from the cancer testis antigen HOM-MEL-40/SSX2Claudia Wagner
Med Klinik I, Saarland University Medical School, D 66424 Homburg, Germany
Cancer Immun 3:18. 2003..p103-111 holds promise as a broadly applicable peptide vaccine for patients with HOM-MEL-40/SSX2 positive neoplasms...
- Virus-specific T-cell responses associated with hepatitis C virus (HCV) persistence in the liver after apparent recovery from HCV infectionJuan A Quiroga
Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
J Med Virol 78:1190-7. 2006....
- Impact of Gag sequence variability on level, phenotype, and function of anti-HIV Gag-specific CD8(+) cytotoxic T lymphocytes in untreated chronically HIV-infected patientsMariola Lopez
Infectious Diseases and Haematology Unit, Hospital Carlos III, 28029 Madrid, Spain
AIDS Res Hum Retroviruses 22:884-92. 2006..These results suggest that viral mutations driven by immune selection pressure may play an important role in evading the immunological response in chronically HIV-infected individuals...
- Differential lysis of tumors by polyclonal T cell lines and T cell clones specific for hTERTDih Yih Chen
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 6:1991-6. 2007..Thus, I540-specific T cells can vary in cytotoxic potential depending on the method of generation, isolation and expansion...
- Detection of antigen-specific T cells in experimental immune-mediated blepharoconjunctivitis in DO11.10 T cell receptor transgenic miceAkemi Ozaki
Laboratory of Immunology, Department of Ophthalmology, Kochi Medical School, Japan
Microbiol Immunol 48:39-48. 2004..The challenge of OVA peptide 323-339 induced EC in DO11.10 TcR-Tg mice without prior sensitization. The response was mediated by CD4(+) Ag-specific T cells. The trafficking of Ag-specific T cells in EC was clearly visualized...
- Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivoChristopher Chiu
Department of Immunology, Wright Fleming Institute, Imperial College, London, and John Radcliffe Hospital, Oxford, UK
Blood 109:1086-94. 2007..However, T-cell proliferation was not observed until 48 hours. We therefore conclude that clonal expansion rather than acquisition of effector function is the rate-limiting step in the development of a primary CTL response...
- Antigen-specific regulatory T cells--their induction and role in infectionKingston H G Mills
Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
Semin Immunol 16:107-17. 2004..Tr1 or Th3 cells are capable of suppressing Th1 and Th2 responses and function in infection to limit pathogen-induced immunopathology, but can also be exploited in therapies for immune-mediated diseases...
- H2-M3-restricted T cells participate in the priming of antigen-specific CD4+ T cellsMichael T Chow
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
J Immunol 177:5098-104. 2006..These results reveal a novel function for H2-M3- and Qa-1-restricted T cells; provision of help to CD4+ Th cells during the primary response...
- Assessment of CD4+ T cells specific for the tumor antigen SSX-1 in cancer-free individualsEmmanuelle Godefroy
Ludwig Institute Clinical Trial Center, Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Cancer Immunol Immunother 56:1183-92. 2007....
- CD28 and CD27 costimulation of CD8+ T cells: a story of survivalDouglas V Dolfi
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Adv Exp Med Biol 590:149-70. 2007....
- Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infectionEster M M van Leeuwen
Department of Internal Medicine, and Laboratory of for Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
J Immunol 173:1834-41. 2004..Thus, CD4(+)CD28(-) T cells emerge as a consequence of CMV infection...
- B cell lipid rafts regulate both peptide-dependent and peptide-independent APC-T cell interactionNiclas Setterblad
Institut National de la Sante et de la Recherche Medicale Unite 396, Institut Universitaire d Hematologie, Hopital St Louis, Paris, France
J Immunol 173:1876-86. 2004..Such peptide-independent conjugates did not retain the ability to activate T cells. Thus, B cell lipid rafts are bifunctional by regulating T cell activation and imposing peptide stringency...
- Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamateHirokuni Kitamei
Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
J Leukoc Biol 79:1193-201. 2006..Regulation of NF-kappaB pathway in the lesion could be a novel target for the successful control of uveoretinitis...
- Identification of novel foot-and-mouth disease virus specific T-cell epitopes in c/c and d/d haplotype miniature swineWilhelm Gerner
Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey, UK
Virus Res 121:223-8. 2006..This is the first report on FMDV specific T-cell epitopes recognized by swine leukocyte antigen (SLA) inbred swine and provides information useful for the design of novel vaccines against FMDV...
- Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infectionsL K Selin
Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA
J Exp Med 183:2489-99. 1996..This demonstrates that virus infections do not occur in immunological isolation, and that CD8+ T cell responses are continually being modulated by other infectious agents...
- Coreceptor CD8-driven modulation of T cell antigen receptor specificityHugo A van den Berg
Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, UK
J Theor Biol 249:395-408. 2007..The functional diversity of the TCR repertoire would therefore be greatly augmented by coreceptor-mediated ligand focussing...
- Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell deathSven G Meuth
Department of Neurology, University of Wurzburg, D 97070 Wurzburg, Germany
J Neurosci 29:15397-409. 2009..Thus, electrical silencing is an immediate consequence of MHC I-restricted interaction of CD8(+) T cells with neurons. This mechanism is clearly perforin-dependent and precedes, but is not causally linked, to neuronal cell death...
- A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarityE M Schad
Department of Molecular Biophysics, Center for Chemistry and Chemical Engineering, Lund University, Sweden
J Mol Biol 269:270-80. 1997..A common Zn2(+)-binding site was identified in both staphylococcal enterotoxin A and C2 that is superimposable but differs somewhat in its coordination geometry between the two molecules...
- Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cellsRemy Bosselut
Laboratory of Immune Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
J Exp Med 197:1709-19. 2003..These results challenge classical concepts of lineage commitment but fulfill predictions of the kinetic signaling model...
- Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptabilityScott R Burrows
Cellular Immunology Laboratory, Queensland Institute of Medical Research and Australian Centre for Vaccine Development, Brisbane 4029, Australia
Proc Natl Acad Sci U S A 107:10608-13. 2010..Collectively, our findings reveal the inherent adaptability of the TCR in maintaining peptide recognition while accommodating changes to the central docking site on the pMHC-I...
- CD4-CD8 lineage commitment: an inside viewDietmar J Kappes
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Nat Immunol 6:761-6. 2005..Finally, identification of the transcription factor Th-POK as a central component of the CD4 lineage-determining pathway has provided a new starting point from which to unravel this intriguing process 'from the inside out'...
- T cell receptor specificity for major histocompatibility complex proteinsPhilippa Marrack
Howard Hughes Medical Institute, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Curr Opin Immunol 20:203-7. 2008..These amino acids may therefore have been selected evolutionarily to predispose T cell receptors toward recognition of MHC ligands...
- Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppressionZ X Zhang
Department of Laboratory of Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada
Nat Med 6:782-9. 2000..These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression...
- The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitmentXiao He
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
Nature 433:826-33. 2005....
- Activated T cells recruit exosomes secreted by dendritic cells via LFA-1Esther N M Nolte-'t Hoen
Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, Utrecht, The Netherlands
Blood 113:1977-81. 2009..These results imply that DC exosomes secreted in the extracellular milieu during cognate T-cell-DC interactions are targeted to T cells activated in that microenvironment...
- Kickstarting Foxp3 with c-RelChyi Song Hsieh
Department of Internal Medicine, Division of Rheumatology, Washington University, Saint Louis, MO 63110, USA
Immunity 31:852-3. 2009..2009) and Ruan et al. (2009) suggest that the transcription factor NF-kappaB-c-Rel is an important molecular mechanism by which T cell receptor-specificity for self-antigens instructs the selection of Foxp3(+) regulatory T cells...
- Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expressionKaren Bunting
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Vitam Horm 74:105-45. 2006..The mechanisms that control IL-2 gene transcription have been studied in detail for the past 20 years and our current understanding of the nature of the inducible and tissue-specific controls will be discussed...
- Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patientsTomohiro Kozako
Division of Host Response, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
J Immunol 177:5718-26. 2006..These results suggest that decreased frequency, diversity, and function of anti-HTLV-1 Tax CD8+ T cell clones may be one of the risks of ATL development...
- Nef interference with HIV-1-specific CTL antiviral activity is epitope specificSama Adnan
Division of Infectious Diseases, 37 121 CHS, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90095, USA
Blood 108:3414-9. 2006..The data thus indicate that HLA-C-restricted CTLs may have an under-appreciated antiviral role in the setting of Nef in vivo and suggest a benefit of promoting HLA-C-restricted CTLs for immunotherapy or vaccine development...
- Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing miceKenneth F May
Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH, USA
Blood 109:253-8. 2007..The immunocompetence of T cells generated in an antigen-bearing host is also confirmed in a skin graft transplantation model...
- Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificitiesMatthias Wolfl
Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA
Blood 110:201-10. 2007....
- Bispecific T-cell engaging antibodies for cancer therapyPatrick A Baeuerle
Micromet Inc, Bethesda, Maryland, USA
Cancer Res 69:4941-4. 2009..Recent results from clinical studies with a CD19/CD3-bispecific BiTE antibody suggest that this therapeutic paradigm is finally showing promise for treatment of both bulky and minimal residual disease...
- Genome-scale search of tumor-specific antigens by collective analysis of mutations, expressions and T-cell recognitionJia Jia
Bioinformatics and Drug Design Group, Department of Pharmacy, and Centre for Computational Science and Engineering, National University of Singapore, Singapore 117543, Singapore
Mol Immunol 46:1824-9. 2009..Such a collective approach has not been explored in spite of the availability and usage of individual methods...
- Investigation of the role of cholera toxin in assisting the initiation of the antigen-specific Th2 responseBai Sui Feng
Department of Gastroenterology, Zhengzhou University School of Medicine, Zhengzhou, China
Immunol Invest 37:782-97. 2008....
- HIV-specific T-cells accumulate in the liver in HCV/HIV co-infectionBahareh Vali
Institute of Medical Science, Department of Medicine, University of Toronto, Toronto, Canada
PLoS ONE 3:e3454. 2008..We examined whether HIV-specific T-cells are identified in the liver of HCV/HIV co-infected individuals and promote liver inflammation through bystander immune responses...
- Non-equilibrium and differential function between intraepithelial and lamina propria virus-specific TCRalphabeta(+) CD8alphabeta(+) T cells in the small intestinal mucosaD Isakov
Molecular Immunogenetics and Vaccine Research Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, Maryland, USA
Mucosal Immunol 2:450-61. 2009..The restricted migration of cells from each of these mucosal compartments could partly account for a founder effect we observed in the IEL TCRalphabeta CD8alphabeta epitope-specific repertoire that might impact protective efficacy...
- Immune responses during acute and chronic infection with hepatitis C virusShigeaki Ishii
Infectious Disease Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Clin Immunol 128:133-47. 2008..Resolution of these outstanding questions is important to the development of a prophylactic vaccine as well as improving therapeutic options for those with chronic infection...
- CD28(-)CD8(+) T cells do not contain unique clonotypes and are therefore dispensableBirgit Weinberger
Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
Immunol Lett 127:27-32. 2009..The elimination of effector T cells would not lead to the loss of important specificities, as relevant clonotypes could be recruited and propagated from naïve or early memory T cell subsets in the case of exposure to pathogen...
- Thymic regulatory T cellsEnrico Maggi
Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
Autoimmun Rev 4:579-86. 2005..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens...
- CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patientsHiroyoshi Nishikawa
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 32 Rm K 817, New York, NY 10021, USA
Blood 106:1008-11. 2005..Memory populations were less sensitive than naive populations to CD4+CD25+ regulatory T cells. We propose that CD4+CD25+ regulatory T cells are involved in the generation and regulation of NY-ESO-1-specific antitumor immunity...
- The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAPBoris V Schmid
Institute of Theoretical Biology, Utrecht University, Utrecht, The Netherlands
PLoS ONE 3:e3525. 2008..We estimate that upon transmission of a virus to a new host 39%-66% of the mutations that caused epitope precursor escapes are released from immune selection pressure...
- Molecular insights for optimizing T cell receptor specificity against cancerMichael Hebeisen
Department of Oncology, Lausanne University Hospital Center CHUV, University of Lausanne, Lausanne, Switzerland
Front Immunol 4:154. 2013....
- T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapyMatthias Leisegang
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Clin Cancer Res 16:2333-43. 2010..We analyzed tumor-infiltrating lymphocytes (TIL) from RCC to identify T-cell specificities with shared tumor-specific recognition to develop T-cell receptor (TCR)-engineered T lymphocytes for adoptive therapy of RCC...
- HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumorsNabil Ahmed
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 16:474-85. 2010....
- Peptide-specific, TCR-alpha-driven, coreceptor-independent negative selection in TCR alpha-chain transgenic miceAnna L Furmanski
Department of Immunology, Hammersmith Hospital, Imperial College London, London, United Kingdom
J Immunol 184:650-7. 2010..These data demonstrate that, in comparison with mature T cells, alphabetaTCR+ immature thymocytes can recognize and transduce signals in response to specific MHC-peptide complexes with relaxed binding requirements...
- Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humansErika Assarsson
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
J Virol 82:12241-51. 2008..These results enable further functional studies of T-cell responses during influenza virus infection and provide a potential base for the development of a universal influenza vaccine...
- T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytesFelix Bohne
Molecular Infectiology, University Hospital Cologne, Koeln, Germany
Gastroenterology 134:239-47. 2008..We therefore aimed at eliminating persistently infected hepatocytes carrying HBV cccDNA by redirecting cytolytic T cells toward HBsAg-producing cells...
- Substantial envelope-specific CD8 T-cell immunity fails to control SIV diseaseViv Peut
Department of Microbiology and Immunology, University of Melbourne, Parkville Victoria, Australia
Virology 384:21-7. 2009..We conclude Env-specific CTL may not be the most effective response to induce by vaccination...
- Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8+ T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ERFarah Aladin
Division of Medical Microbiology, University of Liverpool, Daulby Street, Liverpool, UK
Cancer Immunol Immunother 56:1143-52. 2007..Thus, for immunotherapeutic approaches to target SCLC and other tumours with defects in the MHC class I antigen processing pathway it will be important to consider strategies that address tapasin-defects...
- CD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naïve and antigen-primed T cellsKapilan Kugathasan
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
BMC Immunol 9:48. 2008....
- Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1Beenu Moza
Boston Biomedical Research Institute, Watertown, MA 02472, USA
EMBO J 26:1187-97. 2007..Our data also suggest that protein plasticity plays an exceptionally significant role in this affinity maturation process that results in more than a 3000-fold increase in affinity...
- [Application of molecular modeling to new therapeutic cancer approaches]Olivier Michielin
Centre du cancer de Lausanne, Lausanne
Bull Cancer 94:763-8. 2007..The architecture of this translational research project is presented together with its implications both at the level of basic research as well as in the clinics...
- Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandinsAnnie L Neild
Yale University School of Medicine, Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA
J Immunol 175:8181-90. 2005....
- [Chemokine receptor expression of hepatitis B virus-specific CD8+ lymphocyte in chronic B viral infection]Chun Kyon Lee
Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Koyang, Korea
Taehan Kan Hakhoe Chi 8:363-70. 2002..This study was intended to analyse the pattern of chemokine receptor expression of HBV specific CD 8+ cells in chronic B viral infection...
- A TIP on malaria (genomics)Szymon Kaczanowski
Nat Biotechnol 21:733. 2003
- "T"-ing off on nasopharynx cancerFred Wang
Harvard Medical School, Boston, MA, USA
Blood 105:1841-2. 2005....
- Basic science for the clinician 36: protecting against autoimmunity: tolerance and aire, the immunologic shadow, and other mechanisms of negative selection in the thymusLeonard H Sigal
Pharmaceutical Research Institute, Bristol Myers Squibb, Princeton, NJ 08543 4000, USA
J Clin Rheumatol 12:44-6. 2006..The absence of aire leads to autoimmune polyendocrinopathy, proof that aire is the center of an amazing "filtering" system. These and other molecular mechanisms underlying tolerance are explored in this and the next paper in this series...
- Uptake and presentation of hepatitis C virus-like particles by human dendritic cellsHeidi Barth
Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
Blood 105:3605-14. 2005..Furthermore, HCV-LP-mediated DC activation and efficient antigen presentation may explain the marked immunogenicity of HCV-LPs in vivo...
- Innovative cell-based therapies in onco-hematology: what are the clinical facts ?Martino Introna
Laboratory of Cellular and Gene Therapy G Lanzani, Division of Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy
Haematologica 89:1253-60. 2004..From then on much research has focused on the use of cells to treat different aspects of oncologic diseases from leukemia relapse to development in BMT recipients...
- Regulatory T cells and organ transplantationHerman Waldmann
Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
Semin Immunol 16:119-26. 2004..The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination...
- On immunity against infections and vaccines: credo 2004R M Zinkernagel
Institute of Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Scand J Immunol 60:9-13. 2004..T cells not only play an essential role in maintaining T-help-dependent memory antibody titres, but also in controlling the many infections that persist in a host at rather low levels (such as tuberculosis, measles and HIV)...
- Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infectionJie Yu
Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
J Med Virol 78:1147-57. 2006..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
- Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoidGianfranco Di Genova
Cancer Sciences Division, University of Southampton School of Medicine, Southampton, UK
Eur J Immunol 40:976-85. 2010..This crosstalk between a stimulated CD4(+) memory T-cell response and CD4(+) T cells activated by an unrelated antigen could be important in human subjects continually buffeted by environmental antigens...
- Immunotherapeutic relief from persistent infections and amyloid disordersDorian B McGavern
Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
Neurology 66:S59-64. 2006....
- Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infectionAngel M Padilla
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
J Immunol 183:1245-52. 2009..cruzi by administration of ligands for TLR2 and TLR9 at the time of infection. These studies highlight a previously unappreciated mechanism of immune evasion, the surreptitious establishment of infection, by the protozoan T. cruzi...
- The Eighth Human Leucocyte Differentiation Antigen (HLDA8) Workshop: natural killer cell section reportHilary S Warren
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Cell Immunol 236:17-20. 2005..These were NKG2D (CD314), LAIR-1 (CD305), NKp46 (CD335), NKp44 (CD336), NKp30 (CD337), CRACC (CD319), and NKG2C (CD159c)...
- Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantationIan Horkheimer
Departments of Medicine, Duke University Medical Center, Durham, NC 2771, USA
Blood 113:5330-9. 2009..Collectively, these results may suggest effective immunotherapeutic strategies for treating cancer after stem cell transplantation...
- T-cell tolerance to inhaled allergens: mechanisms and therapeutic approachesMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
Expert Opin Biol Ther 8:769-77. 2008..Specific immune response to allergens is decisive in the development of clinically healthy or allergic states...
- MAPK3 deficiency drives autoimmunity via DC armingIvo Bendix
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Eur J Immunol 40:1486-95. 2010..Therefore, triggering of MAPK3 in the periphery might be a therapeutic option for the treatment of neuroinflammation since absence of this kinase in the immune system leads to severe EAE...
- An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cellsJohn Stambas
Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
J Immunol 178:1285-92. 2007..These experiments provide insights that may be of value for adoptive immunotherapy, where careful consideration of both the activation state and the number of effector cells is required...
- Costimulation of memory T-cells by ICOS: a potential therapeutic target for autoimmunity?R A Sporici
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Clin Immunol 100:263-9. 2001..ICOS, a receptor that appears to be involved in the costimulation of previously activated T-cells, may be an attractive alternative...
- PROTECTIVE AUTOREACTIVE T CELL CLONES FROM NOD MICEHELEN TAN; Fiscal Year: 1999..Studies directed at delineating elements that promote development of protective T effector functions could point to new strategies for therapeutic intervention. ..
- NKT Cell Recognition of Streptococcus PneumoniaeMitchell Kronenberg; Fiscal Year: 2008..pneumoniae, which could lead to the development of more effective vaccines against this organism. [unreadable] [unreadable] [unreadable] [unreadable]..
- Activation and Tolerance in Neonatal T Cells and Recent Thymic EmigrantsDAVID RANDOLPH; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- 2007 Immunobiology and Immunochemistry Gordon Research ConferenceMitchell Kronenberg; Fiscal Year: 2007..Participation by women and under represented minorities[unreadable] is actively sought. In this application, we seek support for this important and prestigious[unreadable] conference. ..
- Regulation of normal human IEL by NKG2D and IL-15Bana Jabri; Fiscal Year: 2010....
- Transcriptional Control of AICDA ExpressionFerenc Livak; Fiscal Year: 2005..abstract_text> ..
- Cellular Immunotherapy for Neuroblastoma With CTL clonesMichael Jensen; Fiscal Year: 2002..4.) To assess in this patient population the development of antibody and cellular immune responses against the scFvFc:zeta and HyTK chimeric proteins. ..
- Poly-functional analyses of vaccine-induced T cell responsesGuido Ferrari; Fiscal Year: 2010..Overall, these findings will shed new insights on the importance and fate of vaccine-induced T cell responses in controlling HIV-infection. ..
- Glioma Immunotherapy Usingengineered T-CellsMichael Jensen; Fiscal Year: 2006..These data will form the basis for designing Phase I/II trials using enhanced T-cell dosing schedules, imaging techniques, and surrogate marker endpoints. ..
- Immune cell dynamics during central nervous system viral infectionJUAN DE LA TORRE; Fiscal Year: 2008..abstract_text> ..
- Novel Vaccines for SmallpoxDavid Weiner; Fiscal Year: 2007..Together these studies will establish if this simple and novel approach can bridge the current situation and produce a safer more effective smallpox vaccine. [unreadable] [unreadable]..
- Antigen Presentation Pathway by CD1 MoleculesMitchell Kronenberg; Fiscal Year: 2006..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
- Recognition of bacterial antigens by NKT cellsMitchell Kronenberg; Fiscal Year: 2010..abstract_text> ..
- T Cell Immunity & Liver Fibrosis in HCV/HIV CoinfectionChihiro Morishima; Fiscal Year: 2003..Finally, we will test the hypotheses that HCV/HIV coinfected subjects treated with HAART will demonstrate improved HCV-specific CD4+ T cell function that is not fibrogenic, and is sequestered to the liver. ..
- Structure/biology of short-lived MHC II-ligand complexesScheherazade Sadegh Nasseri; Fiscal Year: 2007..Compare peptide repertoires of DO-/-, DM-/- and WT thymic stromal cells 3b. Generate mice expressing a DR1 mutant (DRbG86Y) that participates in short-lived complexes and study thymocyte selection. ..
- In Situ Analysis of Hepatitis B virus-specific T cellsDorian McGavern; Fiscal Year: 2006..The main objective of this research is to more precisely define the contribution of HBV-specific CTL to viral clearance and pathogenesis by providing the first comprehensive analysis of these cells in situ. ..
- Immunochemistry & Immunobiology 2008 Gordon Research ConferenceMitchell Kronenberg; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- T cell Interactions in the CNS During Viral PersistenceDorian McGavern; Fiscal Year: 2005..The main objective of this research is to define the immunologic parameters that contribute to viral clearance versus persistence in the CNS and foster approaches that tip the balance in favor of clearance. ..
- Autoimmune Oophoritis: Consequences of Gamete VaccinesKenneth Tung; Fiscal Year: 2006..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
- ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1Mitchell Kronenberg; Fiscal Year: 2004..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..