t cell antigen receptor specificity

Summary

Summary: The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule.

Top Publications

  1. pmc Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
    Joseph P Casazza
    Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2865-77. 2006
  2. pmc Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection
    Christopher C Kemball
    Molecular and Integrative Neurosciences Dept, SP30 2110, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 82:4331-42. 2008
  3. pmc Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C
    Tobias Manigold
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4424-32. 2006
  4. ncbi Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR
    Jürgen Kuball
    Department of Hematology and Oncology, Johannes Gutenberg University, 55101 Mainz, Germany
    Immunity 22:117-29. 2005
  5. ncbi Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Immunother 31:199-206. 2008
  6. pmc T-cell promiscuity in autoimmune diabetes
    Li Li
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 57:2099-106. 2008
  7. ncbi Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma
    Carmen Choi
    Tumor Immunology Program, The German Cancer Research Center, INF 280, 69 120 Heidelberg, Germany
    Blood 105:2132-4. 2005
  8. ncbi Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes
    Divya J Mekala
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, D 4047, Memphis, TN 38105, USA
    Blood 105:2090-2. 2005
  9. ncbi CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells
    Alexandre Corthay
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Adv Exp Med Biol 590:195-208. 2007
  10. pmc Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cells
    Yi Zeng
    University of Arizona, Department of Pediatrics, Steele Memorial Children s Center, 1501 N Campbell Ave, PO Box 245073, Tucson, AZ 85724 5073, USA
    Blood 105:2016-22. 2005

Detail Information

Publications167 found, 100 shown here

  1. pmc Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
    Joseph P Casazza
    Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2865-77. 2006
    ..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes...
  2. pmc Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection
    Christopher C Kemball
    Molecular and Integrative Neurosciences Dept, SP30 2110, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 82:4331-42. 2008
    ..Finally, our findings have implications for the biological significance of cross-priming, a process thought by some to be important for the induction of antiviral CD8(+) T-cell responses...
  3. pmc Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C
    Tobias Manigold
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4424-32. 2006
    ..This result suggests that HCV infection alters the population of Foxp3(+)CD4(+)CD25(+) T(Reg) cells...
  4. ncbi Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR
    Jürgen Kuball
    Department of Hematology and Oncology, Johannes Gutenberg University, 55101 Mainz, Germany
    Immunity 22:117-29. 2005
    ..The intentional redirection of both CD4+ Th cells and CD8+ CTL by the same high-affinity, CD8-independent, tumor-specific TCR could provide the basis for novel broad-spectrum cancer immunotherapeutics...
  5. ncbi Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Immunother 31:199-206. 2008
    ..Adoptive T-cell transfer could potentially restore T-cell immunity against adenovirus after allogeneic stem cell transplantation...
  6. pmc T-cell promiscuity in autoimmune diabetes
    Li Li
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 57:2099-106. 2008
    ..Nevertheless, the molecular basis for recognition of beta-cell-specific epitopes by pathogenic T-cells remains ill defined; we seek to further explore this issue...
  7. ncbi Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma
    Carmen Choi
    Tumor Immunology Program, The German Cancer Research Center, INF 280, 69 120 Heidelberg, Germany
    Blood 105:2132-4. 2005
    ..BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon gamma (IFN-gamma) secretion, perforin production, and cytotoxicity...
  8. ncbi Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes
    Divya J Mekala
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, D 4047, Memphis, TN 38105, USA
    Blood 105:2090-2. 2005
    ..These results provide proof of principal for a novel approach to enforce the interaction of regulatory and pathologic T lymphocytes, thereby facilitating the treatment of autoimmune disease...
  9. ncbi CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells
    Alexandre Corthay
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Adv Exp Med Biol 590:195-208. 2007
  10. pmc Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cells
    Yi Zeng
    University of Arizona, Department of Pediatrics, Steele Memorial Children s Center, 1501 N Campbell Ave, PO Box 245073, Tucson, AZ 85724 5073, USA
    Blood 105:2016-22. 2005
    ....
  11. pmc Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells
    Eddie W Adams
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immununology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Chembiochem 9:294-303. 2008
    ..Taken together, our data suggest that a DC targeting strategy that is based upon carbohydrate-lectin interactions is a promising approach for enhancing antigen presentation via class I and class II molecules...
  12. pmc Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice
    Kazuyuki Kawamura
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249
    J Immunol 181:3202-11. 2008
    ....
  13. ncbi Immunological changes and cytokine gene expression during primary infection with human T-cell leukaemia virus type 1 in squirrel monkeys (Saimiri sciureus)
    Jean Michel Heraud
    Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, BP6010, 97306 Cayenne, French Guiana, France
    Virology 361:402-11. 2007
    ..Further studies will be needed to determine the effective role of these cytokines and other immune system modulators in the control of viral replication during primary HTLV-1 infection or latency...
  14. ncbi The immunogenicity of dendritic cell-derived exosomes
    Ben J C Quah
    School of Biochemistry and Molecular Biology, Building 41, Linnaeus Way, Australian National University, Canberra, ACT 0200, Australia
    Blood Cells Mol Dis 35:94-110. 2005
    ..The possible function of immature DC and their exosomes in maintenance of tolerance and in the induction of immunity is discussed...
  15. ncbi The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology
    C S Hsieh
    Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USA
    Curr Top Microbiol Immunol 293:25-42. 2005
    ..Here, we will review the available evidence regarding naturally arising TR TCR specificity in the context of TR development, function, and homeostasis...
  16. ncbi Mcl-1 and anticancer vaccination: identification of an HLA-A2-restricted epitope
    R S Andersen
    Leukemia 22:668-9. 2008
  17. pmc Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray
    Xujing Wang
    The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and The Children s Hospital Research Institute of Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 8:329. 2007
    ..We have used the memory T cell repertoire to an influenza-derived peptide as a test case for developing such a method...
  18. pmc Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberation
    Yoshinori Ito
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Virol 80:883-90. 2006
    ....
  19. pmc Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice
    Agnieszka Boesen
    Department of Microbiology and Immunology, City University of New York Medical School, New York, New York 10031, USA
    Clin Diagn Lab Immunol 12:1223-30. 2005
    ..These findings provide direct evidence for the existence of LV-derived GP epitopes that may be useful in the development of protective immunogens for this hemorrhagic virus...
  20. ncbi Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus
    Louise Jones
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford, UK
    Eur J Immunol 37:3393-403. 2007
    ..In summary these data implicate persistent low-level or recurrent VZV antigen exposure in healthy immune donors and are compatible with a role for IE63-specific CD4+ T cells in the control of viral reactivation...
  21. ncbi Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor
    Stefan Gattenlohner
    Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany
    Cancer Res 66:24-8. 2006
    ....
  22. ncbi Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancer
    Michael J Anderson
    Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, National Cancer Institute, National Institutes of Health, Frederick, MD 21701, USA
    J Immunol 178:1268-76. 2007
    ....
  23. ncbi Long-term phenotypic, functional and genetic stability of cancer-specific T-cell receptor (TCR) alphabeta genes transduced to CD8+ T cells
    A Hiasa
    Department of Immuno Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan
    Gene Ther 15:695-9. 2008
    ..Our results indicate that TCR-transduced alphabeta T cells by retroviral transduction represent an efficient and promising strategy for adoptive T-cell transfer for long term...
  24. ncbi Identification of an immunogenic EWS-FLI1-derived HLA-DR-restricted T helper cell epitope
    Friederike Meyer-Wentrup
    Department of Pediatrics, Children s Hospital Medical Center, Munich University of Technology, Munchen, Germany
    Pediatr Hematol Oncol 22:297-308. 2005
    ..The authors report the identification of the first EFT-specific immunogenic T-cell epitope so far. Its identification will lead to a better understanding of EFT immunology and may improve DC-based immunotherapy...
  25. ncbi Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic control
    K S K Tung
    Department of Pathology, Health Science Center, University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA
    Curr Top Microbiol Immunol 293:209-47. 2005
    ..The candidate genes include Pdcd1, TNFR superfamily genes, H2, Il2, Tgfb, Nalp5 or Mater, an oocyte autoAg that reacts with autoantibody in sera of d3tx mice...
  26. ncbi Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection
    A Coutinho
    Laboratoire Européen Associé au CNRS, Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Curr Top Microbiol Immunol 293:43-71. 2005
    ..1974) and in the system's evolution (Coutinho 1975, 1980) as well. After all, major transitions in evolution were cooperative (Maynard-Smith and Szathmary 1995)...
  27. ncbi Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele
    Guido Ferrari
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 173:2126-33. 2004
    ....
  28. doi Identification of human antigen-specific T cells using MHC class I and class II tetramers
    Lori A Krueger
    Beckman Coulter Inc, San Diego, California, USA
    Curr Protoc Cytom . 2004
    ..To minimize nonspecific tetramer binding contributed by irrelevant cell populations, a cumulative gating strategy using positive selection and/or exclusion gating is described...
  29. ncbi Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 173:1966-77. 2004
    ....
  30. ncbi T-cell allorecognition: a case of mistaken identity or déjà vu?
    Julia K Archbold
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Trends Immunol 29:220-6. 2008
    ....
  31. ncbi Identification of an HLA-A*02 restricted immunogenic peptide derived from the cancer testis antigen HOM-MEL-40/SSX2
    Claudia Wagner
    Med Klinik I, Saarland University Medical School, D 66424 Homburg, Germany
    Cancer Immun 3:18. 2003
    ..p103-111 holds promise as a broadly applicable peptide vaccine for patients with HOM-MEL-40/SSX2 positive neoplasms...
  32. ncbi Virus-specific T-cell responses associated with hepatitis C virus (HCV) persistence in the liver after apparent recovery from HCV infection
    Juan A Quiroga
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 78:1190-7. 2006
    ....
  33. ncbi Impact of Gag sequence variability on level, phenotype, and function of anti-HIV Gag-specific CD8(+) cytotoxic T lymphocytes in untreated chronically HIV-infected patients
    Mariola Lopez
    Infectious Diseases and Haematology Unit, Hospital Carlos III, 28029 Madrid, Spain
    AIDS Res Hum Retroviruses 22:884-92. 2006
    ..These results suggest that viral mutations driven by immune selection pressure may play an important role in evading the immunological response in chronically HIV-infected individuals...
  34. ncbi Differential lysis of tumors by polyclonal T cell lines and T cell clones specific for hTERT
    Dih Yih Chen
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 6:1991-6. 2007
    ..Thus, I540-specific T cells can vary in cytotoxic potential depending on the method of generation, isolation and expansion...
  35. ncbi Detection of antigen-specific T cells in experimental immune-mediated blepharoconjunctivitis in DO11.10 T cell receptor transgenic mice
    Akemi Ozaki
    Laboratory of Immunology, Department of Ophthalmology, Kochi Medical School, Japan
    Microbiol Immunol 48:39-48. 2004
    ..The challenge of OVA peptide 323-339 induced EC in DO11.10 TcR-Tg mice without prior sensitization. The response was mediated by CD4(+) Ag-specific T cells. The trafficking of Ag-specific T cells in EC was clearly visualized...
  36. ncbi Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo
    Christopher Chiu
    Department of Immunology, Wright Fleming Institute, Imperial College, London, and John Radcliffe Hospital, Oxford, UK
    Blood 109:1086-94. 2007
    ..However, T-cell proliferation was not observed until 48 hours. We therefore conclude that clonal expansion rather than acquisition of effector function is the rate-limiting step in the development of a primary CTL response...
  37. ncbi Antigen-specific regulatory T cells--their induction and role in infection
    Kingston H G Mills
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Semin Immunol 16:107-17. 2004
    ..Tr1 or Th3 cells are capable of suppressing Th1 and Th2 responses and function in infection to limit pathogen-induced immunopathology, but can also be exploited in therapies for immune-mediated diseases...
  38. ncbi H2-M3-restricted T cells participate in the priming of antigen-specific CD4+ T cells
    Michael T Chow
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 177:5098-104. 2006
    ..These results reveal a novel function for H2-M3- and Qa-1-restricted T cells; provision of help to CD4+ Th cells during the primary response...
  39. ncbi Assessment of CD4+ T cells specific for the tumor antigen SSX-1 in cancer-free individuals
    Emmanuelle Godefroy
    Ludwig Institute Clinical Trial Center, Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Immunol Immunother 56:1183-92. 2007
    ....
  40. ncbi CD28 and CD27 costimulation of CD8+ T cells: a story of survival
    Douglas V Dolfi
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Adv Exp Med Biol 590:149-70. 2007
    ....
  41. ncbi Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection
    Ester M M van Leeuwen
    Department of Internal Medicine, and Laboratory of for Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 173:1834-41. 2004
    ..Thus, CD4(+)CD28(-) T cells emerge as a consequence of CMV infection...
  42. ncbi B cell lipid rafts regulate both peptide-dependent and peptide-independent APC-T cell interaction
    Niclas Setterblad
    Institut National de la Sante et de la Recherche Medicale Unite 396, Institut Universitaire d Hematologie, Hopital St Louis, Paris, France
    J Immunol 173:1876-86. 2004
    ..Such peptide-independent conjugates did not retain the ability to activate T cells. Thus, B cell lipid rafts are bifunctional by regulating T cell activation and imposing peptide stringency...
  43. ncbi Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate
    Hirokuni Kitamei
    Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    J Leukoc Biol 79:1193-201. 2006
    ..Regulation of NF-kappaB pathway in the lesion could be a novel target for the successful control of uveoretinitis...
  44. ncbi Identification of novel foot-and-mouth disease virus specific T-cell epitopes in c/c and d/d haplotype miniature swine
    Wilhelm Gerner
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey, UK
    Virus Res 121:223-8. 2006
    ..This is the first report on FMDV specific T-cell epitopes recognized by swine leukocyte antigen (SLA) inbred swine and provides information useful for the design of novel vaccines against FMDV...
  45. pmc Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections
    L K Selin
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA
    J Exp Med 183:2489-99. 1996
    ..This demonstrates that virus infections do not occur in immunological isolation, and that CD8+ T cell responses are continually being modulated by other infectious agents...
  46. ncbi Coreceptor CD8-driven modulation of T cell antigen receptor specificity
    Hugo A van den Berg
    Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 249:395-408. 2007
    ..The functional diversity of the TCR repertoire would therefore be greatly augmented by coreceptor-mediated ligand focussing...
  47. ncbi Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Neurosci 29:15397-409. 2009
    ..Thus, electrical silencing is an immediate consequence of MHC I-restricted interaction of CD8(+) T cells with neurons. This mechanism is clearly perforin-dependent and precedes, but is not causally linked, to neuronal cell death...
  48. ncbi A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity
    E M Schad
    Department of Molecular Biophysics, Center for Chemistry and Chemical Engineering, Lund University, Sweden
    J Mol Biol 269:270-80. 1997
    ..A common Zn2(+)-binding site was identified in both staphylococcal enterotoxin A and C2 that is superimposable but differs somewhat in its coordination geometry between the two molecules...
  49. pmc Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells
    Remy Bosselut
    Laboratory of Immune Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 197:1709-19. 2003
    ..These results challenge classical concepts of lineage commitment but fulfill predictions of the kinetic signaling model...
  50. pmc Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability
    Scott R Burrows
    Cellular Immunology Laboratory, Queensland Institute of Medical Research and Australian Centre for Vaccine Development, Brisbane 4029, Australia
    Proc Natl Acad Sci U S A 107:10608-13. 2010
    ..Collectively, our findings reveal the inherent adaptability of the TCR in maintaining peptide recognition while accommodating changes to the central docking site on the pMHC-I...
  51. ncbi CD4-CD8 lineage commitment: an inside view
    Dietmar J Kappes
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Nat Immunol 6:761-6. 2005
    ..Finally, identification of the transcription factor Th-POK as a central component of the CD4 lineage-determining pathway has provided a new starting point from which to unravel this intriguing process 'from the inside out'...
  52. pmc T cell receptor specificity for major histocompatibility complex proteins
    Philippa Marrack
    Howard Hughes Medical Institute, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Immunol 20:203-7. 2008
    ..These amino acids may therefore have been selected evolutionarily to predispose T cell receptors toward recognition of MHC ligands...
  53. ncbi Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    Z X Zhang
    Department of Laboratory of Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada
    Nat Med 6:782-9. 2000
    ..These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression...
  54. ncbi The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    Xiao He
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Nature 433:826-33. 2005
    ....
  55. ncbi Activated T cells recruit exosomes secreted by dendritic cells via LFA-1
    Esther N M Nolte-'t Hoen
    Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, Utrecht, The Netherlands
    Blood 113:1977-81. 2009
    ..These results imply that DC exosomes secreted in the extracellular milieu during cognate T-cell-DC interactions are targeted to T cells activated in that microenvironment...
  56. ncbi Kickstarting Foxp3 with c-Rel
    Chyi Song Hsieh
    Department of Internal Medicine, Division of Rheumatology, Washington University, Saint Louis, MO 63110, USA
    Immunity 31:852-3. 2009
    ..2009) and Ruan et al. (2009) suggest that the transcription factor NF-kappaB-c-Rel is an important molecular mechanism by which T cell receptor-specificity for self-antigens instructs the selection of Foxp3(+) regulatory T cells...
  57. ncbi Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expression
    Karen Bunting
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Vitam Horm 74:105-45. 2006
    ..The mechanisms that control IL-2 gene transcription have been studied in detail for the past 20 years and our current understanding of the nature of the inducible and tissue-specific controls will be discussed...
  58. ncbi Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patients
    Tomohiro Kozako
    Division of Host Response, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Immunol 177:5718-26. 2006
    ..These results suggest that decreased frequency, diversity, and function of anti-HTLV-1 Tax CD8+ T cell clones may be one of the risks of ATL development...
  59. pmc Nef interference with HIV-1-specific CTL antiviral activity is epitope specific
    Sama Adnan
    Division of Infectious Diseases, 37 121 CHS, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Blood 108:3414-9. 2006
    ..The data thus indicate that HLA-C-restricted CTLs may have an under-appreciated antiviral role in the setting of Nef in vivo and suggest a benefit of promoting HLA-C-restricted CTLs for immunotherapy or vaccine development...
  60. pmc Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice
    Kenneth F May
    Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH, USA
    Blood 109:253-8. 2007
    ..The immunocompetence of T cells generated in an antigen-bearing host is also confirmed in a skin graft transplantation model...
  61. pmc Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities
    Matthias Wolfl
    Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA
    Blood 110:201-10. 2007
    ....
  62. ncbi Bispecific T-cell engaging antibodies for cancer therapy
    Patrick A Baeuerle
    Micromet Inc, Bethesda, Maryland, USA
    Cancer Res 69:4941-4. 2009
    ..Recent results from clinical studies with a CD19/CD3-bispecific BiTE antibody suggest that this therapeutic paradigm is finally showing promise for treatment of both bulky and minimal residual disease...
  63. ncbi Genome-scale search of tumor-specific antigens by collective analysis of mutations, expressions and T-cell recognition
    Jia Jia
    Bioinformatics and Drug Design Group, Department of Pharmacy, and Centre for Computational Science and Engineering, National University of Singapore, Singapore 117543, Singapore
    Mol Immunol 46:1824-9. 2009
    ..Such a collective approach has not been explored in spite of the availability and usage of individual methods...
  64. ncbi Investigation of the role of cholera toxin in assisting the initiation of the antigen-specific Th2 response
    Bai Sui Feng
    Department of Gastroenterology, Zhengzhou University School of Medicine, Zhengzhou, China
    Immunol Invest 37:782-97. 2008
    ....
  65. pmc HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection
    Bahareh Vali
    Institute of Medical Science, Department of Medicine, University of Toronto, Toronto, Canada
    PLoS ONE 3:e3454. 2008
    ..We examined whether HIV-specific T-cells are identified in the liver of HCV/HIV co-infected individuals and promote liver inflammation through bystander immune responses...
  66. pmc Non-equilibrium and differential function between intraepithelial and lamina propria virus-specific TCRalphabeta(+) CD8alphabeta(+) T cells in the small intestinal mucosa
    D Isakov
    Molecular Immunogenetics and Vaccine Research Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, Maryland, USA
    Mucosal Immunol 2:450-61. 2009
    ..The restricted migration of cells from each of these mucosal compartments could partly account for a founder effect we observed in the IEL TCRalphabeta CD8alphabeta epitope-specific repertoire that might impact protective efficacy...
  67. ncbi Immune responses during acute and chronic infection with hepatitis C virus
    Shigeaki Ishii
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Clin Immunol 128:133-47. 2008
    ..Resolution of these outstanding questions is important to the development of a prophylactic vaccine as well as improving therapeutic options for those with chronic infection...
  68. ncbi CD28(-)CD8(+) T cells do not contain unique clonotypes and are therefore dispensable
    Birgit Weinberger
    Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
    Immunol Lett 127:27-32. 2009
    ..The elimination of effector T cells would not lead to the loss of important specificities, as relevant clonotypes could be recruited and propagated from naïve or early memory T cell subsets in the case of exposure to pathogen...
  69. ncbi Thymic regulatory T cells
    Enrico Maggi
    Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
    Autoimmun Rev 4:579-86. 2005
    ..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens...
  70. ncbi CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients
    Hiroyoshi Nishikawa
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 32 Rm K 817, New York, NY 10021, USA
    Blood 106:1008-11. 2005
    ..Memory populations were less sensitive than naive populations to CD4+CD25+ regulatory T cells. We propose that CD4+CD25+ regulatory T cells are involved in the generation and regulation of NY-ESO-1-specific antitumor immunity...
  71. pmc The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAP
    Boris V Schmid
    Institute of Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 3:e3525. 2008
    ..We estimate that upon transmission of a virus to a new host 39%-66% of the mutations that caused epitope precursor escapes are released from immune selection pressure...
  72. pmc Molecular insights for optimizing T cell receptor specificity against cancer
    Michael Hebeisen
    Department of Oncology, Lausanne University Hospital Center CHUV, University of Lausanne, Lausanne, Switzerland
    Front Immunol 4:154. 2013
    ....
  73. ncbi T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy
    Matthias Leisegang
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Clin Cancer Res 16:2333-43. 2010
    ..We analyzed tumor-infiltrating lymphocytes (TIL) from RCC to identify T-cell specificities with shared tumor-specific recognition to develop T-cell receptor (TCR)-engineered T lymphocytes for adoptive therapy of RCC...
  74. pmc HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 16:474-85. 2010
    ....
  75. ncbi Peptide-specific, TCR-alpha-driven, coreceptor-independent negative selection in TCR alpha-chain transgenic mice
    Anna L Furmanski
    Department of Immunology, Hammersmith Hospital, Imperial College London, London, United Kingdom
    J Immunol 184:650-7. 2010
    ..These data demonstrate that, in comparison with mature T cells, alphabetaTCR+ immature thymocytes can recognize and transduce signals in response to specific MHC-peptide complexes with relaxed binding requirements...
  76. pmc Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humans
    Erika Assarsson
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 82:12241-51. 2008
    ..These results enable further functional studies of T-cell responses during influenza virus infection and provide a potential base for the development of a universal influenza vaccine...
  77. ncbi T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes
    Felix Bohne
    Molecular Infectiology, University Hospital Cologne, Koeln, Germany
    Gastroenterology 134:239-47. 2008
    ..We therefore aimed at eliminating persistently infected hepatocytes carrying HBV cccDNA by redirecting cytolytic T cells toward HBsAg-producing cells...
  78. ncbi Substantial envelope-specific CD8 T-cell immunity fails to control SIV disease
    Viv Peut
    Department of Microbiology and Immunology, University of Melbourne, Parkville Victoria, Australia
    Virology 384:21-7. 2009
    ..We conclude Env-specific CTL may not be the most effective response to induce by vaccination...
  79. ncbi Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8+ T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ER
    Farah Aladin
    Division of Medical Microbiology, University of Liverpool, Daulby Street, Liverpool, UK
    Cancer Immunol Immunother 56:1143-52. 2007
    ..Thus, for immunotherapeutic approaches to target SCLC and other tumours with defects in the MHC class I antigen processing pathway it will be important to consider strategies that address tapasin-defects...
  80. pmc CD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naïve and antigen-primed T cells
    Kapilan Kugathasan
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    BMC Immunol 9:48. 2008
    ....
  81. pmc Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1
    Beenu Moza
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    EMBO J 26:1187-97. 2007
    ..Our data also suggest that protein plasticity plays an exceptionally significant role in this affinity maturation process that results in more than a 3000-fold increase in affinity...
  82. ncbi [Application of molecular modeling to new therapeutic cancer approaches]
    Olivier Michielin
    Centre du cancer de Lausanne, Lausanne
    Bull Cancer 94:763-8. 2007
    ..The architecture of this translational research project is presented together with its implications both at the level of basic research as well as in the clinics...
  83. ncbi Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandins
    Annie L Neild
    Yale University School of Medicine, Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA
    J Immunol 175:8181-90. 2005
    ....
  84. ncbi [Chemokine receptor expression of hepatitis B virus-specific CD8+ lymphocyte in chronic B viral infection]
    Chun Kyon Lee
    Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Koyang, Korea
    Taehan Kan Hakhoe Chi 8:363-70. 2002
    ..This study was intended to analyse the pattern of chemokine receptor expression of HBV specific CD 8+ cells in chronic B viral infection...
  85. ncbi A TIP on malaria (genomics)
    Szymon Kaczanowski
    Nat Biotechnol 21:733. 2003
  86. ncbi "T"-ing off on nasopharynx cancer
    Fred Wang
    Harvard Medical School, Boston, MA, USA
    Blood 105:1841-2. 2005
    ....
  87. ncbi Basic science for the clinician 36: protecting against autoimmunity: tolerance and aire, the immunologic shadow, and other mechanisms of negative selection in the thymus
    Leonard H Sigal
    Pharmaceutical Research Institute, Bristol Myers Squibb, Princeton, NJ 08543 4000, USA
    J Clin Rheumatol 12:44-6. 2006
    ..The absence of aire leads to autoimmune polyendocrinopathy, proof that aire is the center of an amazing "filtering" system. These and other molecular mechanisms underlying tolerance are explored in this and the next paper in this series...
  88. ncbi Uptake and presentation of hepatitis C virus-like particles by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Blood 105:3605-14. 2005
    ..Furthermore, HCV-LP-mediated DC activation and efficient antigen presentation may explain the marked immunogenicity of HCV-LPs in vivo...
  89. ncbi Innovative cell-based therapies in onco-hematology: what are the clinical facts ?
    Martino Introna
    Laboratory of Cellular and Gene Therapy G Lanzani, Division of Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Haematologica 89:1253-60. 2004
    ..From then on much research has focused on the use of cells to treat different aspects of oncologic diseases from leukemia relapse to development in BMT recipients...
  90. ncbi Regulatory T cells and organ transplantation
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
    Semin Immunol 16:119-26. 2004
    ..The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination...
  91. ncbi On immunity against infections and vaccines: credo 2004
    R M Zinkernagel
    Institute of Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Scand J Immunol 60:9-13. 2004
    ..T cells not only play an essential role in maintaining T-help-dependent memory antibody titres, but also in controlling the many infections that persist in a host at rather low levels (such as tuberculosis, measles and HIV)...
  92. ncbi Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    Jie Yu
    Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Med Virol 78:1147-57. 2006
    ..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
  93. ncbi Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid
    Gianfranco Di Genova
    Cancer Sciences Division, University of Southampton School of Medicine, Southampton, UK
    Eur J Immunol 40:976-85. 2010
    ..This crosstalk between a stimulated CD4(+) memory T-cell response and CD4(+) T cells activated by an unrelated antigen could be important in human subjects continually buffeted by environmental antigens...
  94. ncbi Immunotherapeutic relief from persistent infections and amyloid disorders
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Neurology 66:S59-64. 2006
    ....
  95. ncbi Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection
    Angel M Padilla
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    J Immunol 183:1245-52. 2009
    ..cruzi by administration of ligands for TLR2 and TLR9 at the time of infection. These studies highlight a previously unappreciated mechanism of immune evasion, the surreptitious establishment of infection, by the protozoan T. cruzi...
  96. ncbi The Eighth Human Leucocyte Differentiation Antigen (HLDA8) Workshop: natural killer cell section report
    Hilary S Warren
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Cell Immunol 236:17-20. 2005
    ..These were NKG2D (CD314), LAIR-1 (CD305), NKp46 (CD335), NKp44 (CD336), NKp30 (CD337), CRACC (CD319), and NKG2C (CD159c)...
  97. pmc Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation
    Ian Horkheimer
    Departments of Medicine, Duke University Medical Center, Durham, NC 2771, USA
    Blood 113:5330-9. 2009
    ..Collectively, these results may suggest effective immunotherapeutic strategies for treating cancer after stem cell transplantation...
  98. ncbi T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Expert Opin Biol Ther 8:769-77. 2008
    ..Specific immune response to allergens is decisive in the development of clinically healthy or allergic states...
  99. ncbi MAPK3 deficiency drives autoimmunity via DC arming
    Ivo Bendix
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Eur J Immunol 40:1486-95. 2010
    ..Therefore, triggering of MAPK3 in the periphery might be a therapeutic option for the treatment of neuroinflammation since absence of this kinase in the immune system leads to severe EAE...
  100. ncbi An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    J Immunol 178:1285-92. 2007
    ..These experiments provide insights that may be of value for adoptive immunotherapy, where careful consideration of both the activation state and the number of effector cells is required...
  101. ncbi Costimulation of memory T-cells by ICOS: a potential therapeutic target for autoimmunity?
    R A Sporici
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Clin Immunol 100:263-9. 2001
    ..ICOS, a receptor that appears to be involved in the costimulation of previously activated T-cells, may be an attractive alternative...

Research Grants21

  1. PROTECTIVE AUTOREACTIVE T CELL CLONES FROM NOD MICE
    HELEN TAN; Fiscal Year: 1999
    ..Studies directed at delineating elements that promote development of protective T effector functions could point to new strategies for therapeutic intervention. ..
  2. NKT Cell Recognition of Streptococcus Pneumoniae
    Mitchell Kronenberg; Fiscal Year: 2008
    ..pneumoniae, which could lead to the development of more effective vaccines against this organism. [unreadable] [unreadable] [unreadable] [unreadable]..
  3. Activation and Tolerance in Neonatal T Cells and Recent Thymic Emigrants
    DAVID RANDOLPH; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. 2007 Immunobiology and Immunochemistry Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2007
    ..Participation by women and under represented minorities[unreadable] is actively sought. In this application, we seek support for this important and prestigious[unreadable] conference. ..
  5. Regulation of normal human IEL by NKG2D and IL-15
    Bana Jabri; Fiscal Year: 2010
    ....
  6. Transcriptional Control of AICDA Expression
    Ferenc Livak; Fiscal Year: 2005
    ..abstract_text> ..
  7. Cellular Immunotherapy for Neuroblastoma With CTL clones
    Michael Jensen; Fiscal Year: 2002
    ..4.) To assess in this patient population the development of antibody and cellular immune responses against the scFvFc:zeta and HyTK chimeric proteins. ..
  8. Poly-functional analyses of vaccine-induced T cell responses
    Guido Ferrari; Fiscal Year: 2010
    ..Overall, these findings will shed new insights on the importance and fate of vaccine-induced T cell responses in controlling HIV-infection. ..
  9. Glioma Immunotherapy Usingengineered T-Cells
    Michael Jensen; Fiscal Year: 2006
    ..These data will form the basis for designing Phase I/II trials using enhanced T-cell dosing schedules, imaging techniques, and surrogate marker endpoints. ..
  10. Immune cell dynamics during central nervous system viral infection
    JUAN DE LA TORRE; Fiscal Year: 2008
    ..abstract_text> ..
  11. Novel Vaccines for Smallpox
    David Weiner; Fiscal Year: 2007
    ..Together these studies will establish if this simple and novel approach can bridge the current situation and produce a safer more effective smallpox vaccine. [unreadable] [unreadable]..
  12. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2006
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  13. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..
  14. T Cell Immunity & Liver Fibrosis in HCV/HIV Coinfection
    Chihiro Morishima; Fiscal Year: 2003
    ..Finally, we will test the hypotheses that HCV/HIV coinfected subjects treated with HAART will demonstrate improved HCV-specific CD4+ T cell function that is not fibrogenic, and is sequestered to the liver. ..
  15. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
    ..Compare peptide repertoires of DO-/-, DM-/- and WT thymic stromal cells 3b. Generate mice expressing a DR1 mutant (DRbG86Y) that participates in short-lived complexes and study thymocyte selection. ..
  16. In Situ Analysis of Hepatitis B virus-specific T cells
    Dorian McGavern; Fiscal Year: 2006
    ..The main objective of this research is to more precisely define the contribution of HBV-specific CTL to viral clearance and pathogenesis by providing the first comprehensive analysis of these cells in situ. ..
  17. Immunochemistry & Immunobiology 2008 Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  18. T cell Interactions in the CNS During Viral Persistence
    Dorian McGavern; Fiscal Year: 2005
    ..The main objective of this research is to define the immunologic parameters that contribute to viral clearance versus persistence in the CNS and foster approaches that tip the balance in favor of clearance. ..
  19. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
    ..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
  20. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2004
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..