immunologic dose response relationship

Summary

Summary: A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.

Top Publications

  1. ncbi The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent
    M J Smyth
    Cancer Immunology, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    J Immunol 165:2665-70. 2000
  2. ncbi Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination
    Sandra Ebert
    Department of Neurology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Neuroimmunol 159:87-96. 2005
  3. ncbi Direct observation of ligand recognition by T cells
    Darrell J Irvine
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 419:845-9. 2002
  4. ncbi Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection
    David H Dockrell
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
    J Immunol 171:5380-8. 2003
  5. ncbi More is not necessarily better: prozone-like effects in passive immunization with IgG
    Carlos P Taborda
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 170:3621-30. 2003
  6. ncbi Hazard characterisation in food allergen risk assessment: the application of statistical approaches and the use of clinical data
    R W R Crevel
    Safety and Environmental Assurance Centre, Unilever, Bedford MK44 1LQ, UK
    Food Chem Toxicol 45:691-701. 2007
  7. ncbi Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro
    M B Lutz
    Department of Dermatology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 30:1048-52. 2000
  8. ncbi A novel mouse model of experimental asthma
    Sampson B Sarpong
    Department of Pediatrics and Child Health, National Human Genome Center, Howard University, Washington DC 20060, USA
    Int Arch Allergy Immunol 132:346-54. 2003
  9. ncbi A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much?
    S L Taylor
    University of Nebraska, Food Allergy Research and Resource Program, Lincoln, NE 68583, USA
    Clin Exp Allergy 34:689-95. 2004
  10. ncbi A TNF family member LIGHT transduces costimulatory signals into human T cells
    Xiaochun Wan
    Laboratory of Transplantation Immunology, Center Hospitalier de l Universite de Montreal, University of Montreal, Montreal, Quebec, Canada
    J Immunol 169:6813-21. 2002

Research Grants

  1. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
  2. Role of RALBP1 in Xenobiotic and Radiation Resistance
    Sanjay Awasthi; Fiscal Year: 2008
  3. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
  4. Regulation of murine neonatal Th2 function
    REBECCA D ADKINS; Fiscal Year: 2010
  5. Novel Antimicrobial Agents Against M. tuberculosis
    MARCUS HORWITZ; Fiscal Year: 2008
  6. GENETIC TRACING STRATEGIES FOR THE RAT NERVOUS SYSTEM
    Pietro Sanna; Fiscal Year: 2005
  7. Development of tumor based antigen presenting cells
    James Riley; Fiscal Year: 2008
  8. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
  9. T-Cell Responses Predict Influenza Risk in Older Adults
    Janet McElhaney; Fiscal Year: 2004
  10. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003

Detail Information

Publications247 found, 100 shown here

  1. ncbi The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent
    M J Smyth
    Cancer Immunology, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    J Immunol 165:2665-70. 2000
    ..Overall, both NK and NKT cells can contribute to natural and IL-12-induced immunity against tumors, and the relative role of each population is tumor and therapy dependent...
  2. ncbi Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination
    Sandra Ebert
    Department of Neurology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Neuroimmunol 159:87-96. 2005
    ..Costimulation with submaximum concentrations was additive or supraadditive, suggesting that even low concentrations of products of infectious agents can lead to microglial activation via TLRs...
  3. ncbi Direct observation of ligand recognition by T cells
    Darrell J Irvine
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 419:845-9. 2002
    ..This sensitivity is highly dependent on CD4, because blocking this molecule with antibodies renders T cells unable to detect less than about 30 ligands...
  4. ncbi Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection
    David H Dockrell
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
    J Immunol 171:5380-8. 2003
    ..These results suggest that AM play a key role in clearance of bacteria from the lung during subclinical infection and that induction of AM apoptosis contributes to the microbiologic host defense against pneumococci...
  5. ncbi More is not necessarily better: prozone-like effects in passive immunization with IgG
    Carlos P Taborda
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 170:3621-30. 2003
    ..Our findings have implications for the potential contribution of Ab responses to defense against microbial diseases because Ab-mediated immunity may be protective, nonprotective, or even deleterious to the host...
  6. ncbi Hazard characterisation in food allergen risk assessment: the application of statistical approaches and the use of clinical data
    R W R Crevel
    Safety and Environmental Assurance Centre, Unilever, Bedford MK44 1LQ, UK
    Food Chem Toxicol 45:691-701. 2007
    ....
  7. ncbi Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro
    M B Lutz
    Department of Dermatology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 30:1048-52. 2000
    ..These findings might contribute to the understanding of reduced T cell immunity in the course of septic shock and find application in DC-mediated tolerogenic immunotherapy strategies...
  8. ncbi A novel mouse model of experimental asthma
    Sampson B Sarpong
    Department of Pediatrics and Child Health, National Human Genome Center, Howard University, Washington DC 20060, USA
    Int Arch Allergy Immunol 132:346-54. 2003
    ..The tested hypothesis was that there are enhanced effects of exposure to r Bla g 2 and r Der f 1 allergens in the airway inflammatory response in A/J mice...
  9. ncbi A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much?
    S L Taylor
    University of Nebraska, Food Allergy Research and Resource Program, Lincoln, NE 68583, USA
    Clin Exp Allergy 34:689-95. 2004
    ..While low-dose challenge trials have been conducted on an appreciable number of allergic individuals, a variety of different clinical protocols were used making the estimation of the threshold dose very difficult...
  10. ncbi A TNF family member LIGHT transduces costimulatory signals into human T cells
    Xiaochun Wan
    Laboratory of Transplantation Immunology, Center Hospitalier de l Universite de Montreal, University of Montreal, Montreal, Quebec, Canada
    J Immunol 169:6813-21. 2002
    ..These data suggest that TR6 delivers costimulation through its ligand(s) on the T cell surface, and at least the major part of such costimulation is via LIGHT...
  11. ncbi Depending on their maturation state, splenic dendritic cells induce the differentiation of CD4(+) T lymphocytes into memory and/or effector cells in vivo
    Magali de Heusch
    Institut de Biologie et Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    Eur J Immunol 34:1861-9. 2004
    ..These observations, together with data in the literature, suggest that DC may induce tolerance, memory, or immunity depending on their maturation state...
  12. ncbi Gene gun bombardment with gold particles displays a particular Th2-promoting signal that over-rules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines
    Richard Weiss
    Institute of Chemistry and Biochemistry, University of Salzburg, Hellbrunner Street 34, A 5020 Salzburg, Austria
    Vaccine 20:3148-54. 2002
    ..Furthermore, the data also indicate a strong and even systemic adjuvant effect of the gene gun shot itself...
  13. ncbi Histone peptide-induced nasal tolerance: suppression of murine lupus
    Henry Yim Wu
    Infection and Immunity Research Group, Division of Life Sciences, King s College London, London, United Kingdom
    J Immunol 169:1126-34. 2002
    ..Finally, chronic nasal instillation of mice with the H471 peptide not only suppressed the development of autoantibodies, but also altered the severity of glomerulonephritis in lupus-prone SNF(1) mice...
  14. ncbi The induction of systemic and mucosal immunity to protein vaccines delivered through skin sites exposed to UVB
    Elena Y Enioutina
    Department of Pathology, University of Utah, 30 N 1900 East, Salt Lake City 84132 2501, USA
    Vaccine 20:2116-30. 2002
    ..Our data indicates that the skin, as a vaccination site, can be manipulated to allow efficient induction of common mucosal and systemic immune responses...
  15. pmc Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS-independent T-cell apoptosis
    Christian Termeer
    Department of Dermatology, University of Freiburg, Germany
    Immunology 109:32-40. 2003
    ..Taken together, we found that perturbation of distinct epitopes of CD44 on DC interfere with early Ca2+ signalling events during the activation of CD4+ T cells, resulting in T-cell apoptosis...
  16. ncbi Outer membrane protein A of Acinetobacter baumannii induces differentiation of CD4+ T cells toward a Th1 polarizing phenotype through the activation of dendritic cells
    Jun Sik Lee
    Department of Pharmacy, Pusan National University College of Pharmacy, Busan 609 735, South Korea
    Biochem Pharmacol 74:86-97. 2007
    ..Our findings suggest that AbOmpA induces maturation of DCs and drives Th1 polarization, which are important properties for determining the nature of immune response against A. baumannii...
  17. ncbi IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity
    S Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 13:1471-8. 2001
    ..These observations indicate that IL-1alpha, but not IL-1beta, plays a crucial role in TNCB-induced CHS by sensitizing TNP-specific T cells...
  18. ncbi Activation of dendritic cells and induction of T cell responses by HPV 16 L1/E7 chimeric virus-like particles are enhanced by CpG ODN or sorbitol
    Eva Jasmin Freyschmidt
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Antivir Ther 9:479-89. 2004
    ..Implementing our results in clinical trial protocols may lead to improved activity of therapeutic HPV vaccines for the treatment of HPV-induced cancer...
  19. pmc Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure
    Seong Ok Park
    Department of Microbiology, College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju, Republic of Korea
    Immunology 123:426-37. 2008
    ..These results suggest that primary TCR stimulation is important for developing optimal effectors during initial antigen exposure to confer long-lasting memory CD4+ T cells in response to secondary exposure...
  20. pmc Immunization onto bare skin with synthetic peptides: immunomodulation with a CpG-containing oligodeoxynucleotide and effective priming of influenza virus-specific CD4+ T cells
    Anne Sophie Beignon
    Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Immunology 105:204-12. 2002
    ..Furthermore, with the selection and combination of the appropriate type of adjuvants, immune responses can be modulated towards the desired type of Th phenotype...
  21. ncbi T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody
    Alison L Tutt
    Tenovus Research Laboratory, Cancer Sciences Division, University School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 168:2720-8. 2002
    ..These data underline the ability of anti-CD40 mAb to potentiate CTL responses and the potency of cellular immunity in eradicating large quantities of syngeneic tumor...
  22. ncbi Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3052, Australia
    Vaccine 20:1877-86. 2002
    ..Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-gamma and IL-4 production when compared to unconjugated controls...
  23. ncbi Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen
    Wataru Ise
    Department of Applied Biological Chemistry, University of Tokyo, Japan
    J Immunol 168:3242-50. 2002
    ..Thus, in the primary response, naive CD4(+) T cells can exhibit different functions depending on the dose of Ag...
  24. ncbi Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Victoria, Australia
    J Immunol 173:4643-51. 2004
    ..Of general significance, the findings also indicate that the nature of the stimulus is quite critical in determining whether a particular inflammatory mediator, such as GM-CSF, plays a role in an ensuing inflammatory reaction...
  25. ncbi Dendritic cells pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MHC class I-restricted cytotoxic T cells
    Detlef Stober
    Institute of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany
    Eur J Immunol 32:1099-108. 2002
    ..HBsAg particles thus efficiently enter an alternative processing pathway in DC that leads to presentation of epitopes to MHC class I-restricted CTL...
  26. ncbi IgE- and FcepsilonRI-mediated enhancement of surface CD69 expression in basophils: role of low-level stimulation
    Maho Suzukawa
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 143:56-9. 2007
    ..Upregulated CD69 expression on locally accumulated basophils in bronchial asthma may be attributed at least in part to a combination of local cytokines, especially IL-3, plus exposure to low levels of IgE-crosslinking allergens...
  27. ncbi Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses
    Fabienne Anjuere
    Institut National de la Sante et de la Recherche Medicale, Nice, France
    J Immunol 170:1586-92. 2003
    ....
  28. pmc Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release
    M Arredouani
    Laboratory for Experimental Immunology, Gasthuisberg University Hospital, Leuven, Belgium
    Immunology 108:144-51. 2003
    ..We conclude that Hp plays a modulating role on the Th1/Th2 balance by promoting a dominant Th1 cellular response. This points to a role of acute-phase proteins in balancing immune responses...
  29. ncbi Opposing signals from pathogen-associated molecular patterns and IL-10 are critical for optimal dendritic cell induction of in vivo humoral immunity to Streptococcus pneumoniae
    Jesus Colino
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 171:3508-19. 2003
    ..These data demonstrate a requirement for properly balanced positive and negative signaling in DC to optimize an in vivo immune response to a pathogen...
  30. ncbi Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells
    Fred D Finkelman
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 172:3808-13. 2004
    ....
  31. pmc The primary responses of murine neonatal lymph node CD4+ cells are Th2-skewed and are sufficient for the development of Th2-biased memory
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    Clin Dev Immunol 10:43-51. 2003
    ..These results suggest that the early development of Th2-dominant responses by lymph node CD4+ cells contributes substantially to the subsequent development of Th2-dominant memory in neonates...
  32. ncbi Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    J Immunol 172:5553-60. 2004
    ....
  33. ncbi Individual analysis of mice vaccinated against a weakly immunogenic self tumor-specific antigen reveals a correlation between CD8 T cell response and antitumor efficacy
    Antonio Rosato
    Immunology Section, Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    J Immunol 171:5172-9. 2003
    ..These results highlight the critical need to identify reliable, specific immunological parameters that may predict success or failure of an immune response against cancer...
  34. ncbi Maximum immunobioactivity of murine small intestinal intraepithelial lymphocytes resides in a subpopulation of CD43+ T cells
    Heuy Ching Wang
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, 6516 M D Anderson Boulevard, Houston, TX 77030, USA
    J Immunol 173:6294-302. 2004
    ..These findings define two functionally distinct populations of IELs based on CD43 expression independent of TCR class, and they identify a subset of IELs that may serve as a target to better control intestinal inflammation...
  35. ncbi Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) is a potent enhancer of mixed Th1/Th2 immune responses in mice immunized with influenza virus antigens
    George Mutwiri
    Vaccine and Infectious Disease Organization, 120 Veterinary Road, Saskatoon, SK, Canada S7N 5E3
    Vaccine 25:1204-13. 2007
    ..In contrast, PCEP was associated with production of both IFNgamma and IL-4. We conclude that PCEP is a potent enhancer of antigen-specific Th1 and Th2 immune responses and is a promising adjuvant for vaccine applications...
  36. ncbi Leishmania-induced inhibition of macrophage antigen presentation analyzed at the single-cell level
    Courtney L Meier
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Immunol 171:6706-13. 2003
    ..This study represents the first direct single-cell analysis of the impact of intracellular infection on the interaction of macrophages with T cells and serves to emphasize the subtle influence Leishmania has on APC function...
  37. ncbi The cholera toxin B subunit directly costimulates antigen-primed CD4+ T cells ex vivo
    M Wang
    Islet Discovery Research, Novo Nordisk A S, Bagsvaerd, Denmark
    Scand J Immunol 58:342-9. 2003
    ..This new insight might be valuable in the future rational design of bacterial toxin-based vaccines...
  38. pmc The role of antigen-presenting cells and interleukin-12 in the priming of antigen-specific CD4+ T cells by immune stimulating complexes
    Neil C Robson
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, UK
    Immunology 110:95-104. 2003
    ..We suggest that DC are the principal APC responsible for the priming of CD4+ T cells by ISCOMs in vivo and that directed targeting of these vectors to DC may enhance their efficancy as vaccine adjuvants...
  39. ncbi Selective induction of high avidity CTL by altering the balance of signals from APC
    SangKon Oh
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:2523-30. 2003
    ..Our data also suggested that dendritic cells play an important role in induction of high avidity CD8(+) CTL in vivo. This strategy to selectively induce higher avidity CTL may lead to more effective vaccines for viruses and cancer...
  40. ncbi A pool of central memory-like CD4 T cells contains effector memory precursors
    J Magarian Blander
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520, USA
    J Immunol 170:2940-8. 2003
    ..Having these properties, the L51S TCR transgenic memory CD4 T cells cannot be classified as either strict central memory or effector memory, but, rather, as a pool of memory T cells containing effector memory precursors...
  41. ncbi CD28 signal enhances apoptosis of CD8 T cells after strong TCR ligation
    Xue Zhong Yu
    Human Immunogenetics Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 170:3002-6. 2003
    ..These results indicate that the CD28 signal can down-regulate peripheral T cell responses by increasing apoptosis when TCR ligation exceeds a critical threshold...
  42. pmc Tolerization of an established alphaB-crystallin-reactive T-cell response by intravenous antigen
    Richard Verbeek
    Department of Biosciences, TNO Quality of Life, Leiden, The Netherlands
    Immunology 121:416-26. 2007
    ..In contrast, serum antibody levels were markedly increased. Our data clarify that in the absence of any natural form of immune regulation, antigen-specific memory/effector T cells can be effectively silenced by intravenous antigen...
  43. ncbi Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4+CD25+ regulatory T cells in vivo
    Susanna Grundström
    Active Biotech Research AB, Lund, Sweden
    J Immunol 170:5008-17. 2003
    ....
  44. ncbi T helper responses to Japanese encephalitis virus infection are dependent on the route of inoculation and the strain of mouse used
    C Ramakrishna
    Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
    J Gen Virol 84:1559-67. 2003
    ..001), where an initial Th2-type response reverted to a Th1 response after repeated immunization. Live JEV induced a Th1 response while the commercial killed vaccine induced a predominant Th2 profile...
  45. pmc Induction of T-cell activation or anergy determined by the combination of intensity and duration of T-cell receptor stimulation, and sequential induction in an individual cell
    Tomohiro Yamamoto
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Immunology 121:383-91. 2007
    ..We also show that the calcineurin signal controlled the induction of activation or anergy depending on the activity. This study contributes to better understanding of the precise mechanism for inducing T-cell anergy...
  46. ncbi Regulatory roles of IL-2 and IL-4 in H4/inducible costimulator expression on activated CD4+ T cells during Th cell development
    Junji Yagi
    Department of Microbiology and Immunology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Immunol 171:783-94. 2003
    ..These data suggest that IL-4 induced by IL-2 is critical to the maintenance of high H4/ICOS expression on BALB/c-activated CD4(+) T cells...
  47. ncbi Adjuvant costimulation during secondary antigen challenge directs qualitative aspects of oral tolerance induction, particularly during the neonatal period
    Iriani T Tobagus
    Telethon Institute for Child Health Research, and Center for Child Health Research, Faculty of Medicine and Dentistry, University of Western Australia, Perth, Western Australia, Australia
    J Immunol 172:2274-85. 2004
    ....
  48. ncbi Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells
    H Shirota
    First Department of Internal Medicine and Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 167:66-74. 2001
    ..The DNA-mediated promotion of Ag uptake would be advantageous for evoking host immune responses against invading microorganisms...
  49. ncbi IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation
    L A Geiselhart
    Laboratory of Experimental Immunology, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Immunol 166:3019-27. 2001
    ..These findings may suggest a unique clinical niche for IL-7 in that IL-7 therapy may increase T cell numbers and enhance responses to specific antigenic targets while avoiding a general, nonspecific activation of the T cell population...
  50. ncbi Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets
    Gi Young Kim
    Department of Microbiology and Immunology, and National Research Lab of Dendritic Cell Differentiation and Regulation and Medical Research Institute, Pusan National University College of Medicine, Pusan, South Korea
    J Immunol 174:8116-24. 2005
    ..These novel findings open perspectives for the understanding of the immunopharmacological role of curcumin and therapeutic adjuvants for DC-related acute and chronic diseases...
  51. ncbi The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFN-gamma production
    Katrin D Mayer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:7732-9. 2005
    ..Highly eYFP fluorescent cells produced elevated levels of proinflammatory cytokines and chemokines in addition to IFN-gamma, suggesting their coregulated expression as a functional unit in highly differentiated effector T cells...
  52. ncbi Acquisition of CD80 (B7-1) by T cells
    H Sabzevari
    Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2505-13. 2001
    ..Thus we demonstrate both immunostimulatory and immunoregulatory functions as a result of CD80 acquisition by different T cell populations...
  53. ncbi Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression
    Maria Cecilia Rodriguez-Galan
    Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 174:2796-804. 2005
    ....
  54. ncbi Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin
    An De Creus
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 174:2037-45. 2005
    ..These data suggest that comparatively low expression of TLR4 by liver DC may limit their response to specific ligands, resulting in reduced or altered activation of hepatic adaptive immune responses...
  55. ncbi CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo
    E Assarsson
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Immunol 165:3673-9. 2000
    ..1+CD8+ T cells in the lungs of influenza virus-infected mice. These data suggest that CD8+ T cells can acquire NK1.1 and other NK cell-associated molecules upon appropriate stimulation in vitro and in vivo...
  56. ncbi Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice
    M N Kweon
    Department of Oral Biology, The Immunobiology Vaccine Center, University of Alabama at Birmingham 35294, USA
    J Immunol 160:1687-93. 1998
    ..g., IL-4), which provided help for systemic OVA-specific serum IgG1 and IgG2b Ab responses. These findings clearly indicate a central role for IFN-gamma in the induction and maintenance of mucosally induced tolerance...
  57. ncbi Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigen
    Sarah Buchan
    Molecular Immunology Group, Southampton University Hospitals Trust, Southampton, United Kingdom
    J Immunol 174:6292-8. 2005
    ..Therefore, boosting may not require viral vectors, but simply a physical change in delivery, facilitating application to the cancer clinic...
  58. ncbi Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo Th cell responses
    Y Hamano
    Department of Molecular Genetics, Chiba University Graduate School of Medicine, Japan
    J Immunol 164:6113-9. 2000
    ..Therefore, they suggest that the FcRs on APCs mediate efficient priming of Th cell responses in vivo in an immune complex-dependent manner...
  59. ncbi Generation and characterization of a novel anti-rat CD40L antibody with inhibitory activities in vitro and in vivo
    Annelein M Stax
    Department Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol Methods 335:46-52. 2008
    ..Elucidating the effect of AS1 in various rat models for human diseases will provide more insight into blocking the CD40-CD40L interaction as a therapeutic strategy to prevent human diseases...
  60. ncbi Nasal exposure to Staphylococcal enterotoxin enhances the development of allergic rhinitis in mice
    M Okano
    Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Exp Allergy 35:506-14. 2005
    ..Staphylococcal enterotoxins (SEs) appear to play a role in the pathogenesis of allergic disease. However, little is known whether the nasal exposure to SE affects the development of allergic rhinitis (AR)...
  61. pmc Modulation of a heterologous immune response by the products of Ascaris suum
    Jacqueline C M Paterson
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, USA
    Infect Immun 70:6058-67. 2002
    ..Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths...
  62. ncbi Fas/Fas ligand pathway, apoptosis, and clonal anergy involved in systemic acetylcholine receptor T cell epitope tolerance
    C Deng
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 166:3458-67. 2001
    ..The findings implicate the possible role of Fas-/Fas ligand-mediated apoptosis and the resulting clonal anergy as the mechanisms of high dose AChR alpha 146--162 peptide-induced tolerance on CD4 cells...
  63. ncbi Interleukin-11 modulates Th1/Th2 cytokine production from activated CD4+ T cells
    M Bozza
    Department of Molecular Medicine, Genetics Institute, Andover, MA 01810, USA
    J Interferon Cytokine Res 21:21-30. 2001
    ..rHuIL-11 had no effect on T cell proliferation. The ability of rHuIL-11 to modulate cytokine production from activated CD4(+) T cells provides a mechanism through which rHuIL-11 may ameliorate such inflammatory diseases as psoriasis...
  64. ncbi Different respiratory syncytial virus and Quillaja saponin formulations induce murine peritoneal cells to express different proinflammatory cytokine profiles
    K F Hu
    Faculty of Veterinary Medicine, Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    FEMS Immunol Med Microbiol 31:105-12. 2001
    ..Peak values for production of TNF-alpha and IL-6 were at 8 h and for IL-1alpha at 72 h following stimulation with ISCOM. The delayed appearance of IL-1alpha may reflect the cell-bound nature of this cytokine...
  65. ncbi Whole blood cytokine response as a measure of immunotoxicity
    I Langezaal
    Biochemical Pharmacology, University of Konstanz, 78457 Konstanz, Germany
    Toxicol In Vitro 15:313-8. 2001
    ..This report summarizes our own use of this model with special emphasis on immunotoxicological studies. Our own listed bibliography gives access to the variety of applications of the human whole blood model since its introduction in 1982...
  66. pmc gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovani
    Swati Bhowmick
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700032, India
    Infect Immun 76:1003-15. 2008
    ..Our results demonstrated that stable cationic liposomes containing gp63 acted as a potent adjuvant for protein antigen to induce long-term protection against L. donovani that represents an alternative to DNA vaccination...
  67. ncbi Prolonged culture of vaccine-primed lymphocytes results in decreased antitumor killing and change in cytokine secretion
    Jeffrey J Sussman
    Department of Surgery, Division of Surgical Oncology, University of Cincinnati, Cincinnati, Ohio, USA
    Cancer Res 64:9124-30. 2004
    ..The T-cell cytokine secretion pattern predicts decreased effector cell function and may explain the decreased antitumor effect...
  68. ncbi The immunogenicity of a conformationally restricted peptide mimetic of meningococcal lipooligosaccharide
    H Tiwana
    Centre for Medical Microbiology, Hampstead Campus, University College London, UK
    Scand J Immunol 62:385-92. 2005
    ..There was no serum bactericidal activity observed against the meningococcus...
  69. ncbi Effects of interferon-beta on the cytokine production of astrocytes
    Kazumasa Okada
    Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu 807 8555, Japan
    J Neuroimmunol 159:48-54. 2005
    ..IFN-gamma augmented the effect of IFN-beta on IL-6 production. These results suggest that IFN-beta has an activity to modulate inflammatory and immune responses by up-regulating IL-6 in the CNS of MS...
  70. ncbi Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    C A Piccirillo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 167:1137-40. 2001
    ....
  71. ncbi Actin polymerization enhances Pasteurella haemolytica leukotoxicity
    R J Basaraba
    Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, USA
    Vet Microbiol 64:307-21. 1999
    ..The interaction between P. haemolytica and actin is potentially detrimental to the host by inducing polymerization of actin into insoluble filaments and by enhancing leukotoxicity...
  72. pmc The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease
    Shreeram Akilesh
    The Jackson Laboratory, Bar Harbor, Maine, USA
    J Clin Invest 113:1328-33. 2004
    ..The results suggest that FcRn is a potential therapeutic target that links the initiation and effector phases of humoral autoimmune disease...
  73. ncbi High-dose immunoglobulin therapy for Guillain-Barré syndrome in Japanese children
    Junichi Yata
    Pediatr Int 45:543-9. 2003
    ..However, a well-controlled study of pediatric GBS has not been conducted in Japan. Therefore, to evaluate the efficacy of IVIg in the treatment of GBS, an open-labeled study was performed in pediatric patients...
  74. ncbi Occupational issues of allergic contact dermatitis
    Klaus E Andersen
    Department of Dermatology, Odense University Hospital, 5000 Odense, Denmark
    Int Arch Occup Environ Health 76:347-50. 2003
    ..The local lymph node assay (LLNA), which is an objective and sensitive mouse assay has now been internationally validated and accepted...
  75. ncbi Synthesis, immunosuppressive activity and structure-activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues
    Mi Yeon Jang
    Catholic University of Leuven, Rega Institute, Laboratory of Medicinal Chemistry, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Bioorg Med Chem Lett 20:844-7. 2010
    ..Evaluation of their immunosuppressive activity in a Mixed Lymphocyte Reaction (MLR) assay revealed that the most potent compound has an IC(50)-value of 66 nM and therefore deserves attention for further medicinal chemistry optimization...
  76. pmc Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis
    P T Brinkkoetter
    V Department of Medicine Nephrology, University Hospital Mannheim, University of Heidelberg, Germany
    Clin Exp Immunol 146:524-32. 2006
    ..Activation of Rho, Rac and Ras were strongly reduced in AT-treated T cells, suggesting that impaired geranylation of these molecules might underlie the inhibitory effect of AT on T cell proliferation...
  77. ncbi Long-term repetitive sodium lauryl sulfate-induced irritation of the skin: an in vivo study
    Nara Branco
    Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143 0989, USA
    Contact Dermatitis 53:278-84. 2005
    ..Alternative models should be developed to prove or disprove the accommodation hypothesis...
  78. ncbi Bronchoprovocation studies in basidiospore-sensitive allergic subjects with asthma
    M Lopez
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112
    J Allergy Clin Immunol 84:242-6. 1989
    ..These results demonstrate that basidiospore extracts can induce bronchospasm in subjects with asthma who demonstrate IgE antibodies to basidiospore allergens...
  79. ncbi Comparison study of the immunogenicity and safety of 5- and 10-microgram dosages of a recombinant hepatitis B vaccine in healthy children
    J Goldfarb
    Rainbow Babies and Children s Hospital, Cleveland Clinic Children s Hospital, OH, USA
    Pediatr Infect Dis J 15:768-71. 1996
    ..To compare the immunogenicity and safety of 5 micrograms with 10 micrograms of Engerix-B recombinant hepatitis B vaccine when given to healthy children, 2 to 6 years of age...
  80. ncbi Evaluation of protective immunity of 28KD-GST as a vaccine against experimental Schistosoma mansoni
    Mohsen M Hassan
    Department of Parsitology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Governorate, Egypt
    J Egypt Soc Parasitol 39:403-12. 2009
    ..On the other hand, highly significant (P < 0.001) decrease in circulating antigen, grnuloma number and size in the same group...
  81. pmc Respiratory allergy to Blomia tropicalis: immune response in four syngeneic mouse strains and assessment of a low allergen-dose, short-term experimental model
    Tiana Baqueiro
    Departamento de Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Av, Reitor Miguel Calmon, Canela, Salvador, Bahia, CEP 40110902, Brasil
    Respir Res 11:51. 2010
    ..The relevance and reproducibility of experimental animal models of allergy depends on the genetic background of the animal, the molecular composition of the allergen and the experimental protocol...
  82. ncbi Acute renal failure complicating high-dose intravenous immunoglobulin therapy for acquired haemophilia
    M D McColl
    Haemophilia Centre, Royal Infirmary, Glasgow, UK
    Haemophilia 5:124-6. 1999
    ..All patients receiving such treatment should have renal function carefully monitored both during and after the infusion...
  83. ncbi Induction of TARC production by lipopolysaccharide and interleukin-4 in nasal fibroblasts
    Akira Fukumoto
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Int Arch Allergy Immunol 145:291-7. 2008
    ..Second, we investigated whether there was any heterogeneity in TARC production among fibroblasts derived from different airway sites...
  84. ncbi Dietary intake of Lactobacillus rhamnosus HNOO1 enhances production of both Th1 and Th2 cytokines in antigen-primed mice
    Martin L Cross
    Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
    Med Microbiol Immunol 191:49-53. 2002
    ....
  85. pmc Modulation of human monocytes by Escherichia coli heat-labile enterotoxin B-subunit; altered cytokine production and its functional consequences
    Victor Turcanu
    University of Bristol, Department of Pathology and Microbiology, School of Medical Sciences, UK
    Immunology 106:316-25. 2002
    ..Sorting experiments showed that IL-10 secreting T cells from the MLR cultures were strong suppressors of T-cell proliferation following their addition into a fresh primary MLR...
  86. pmc A novel model of sensitization and oral tolerance to peanut protein
    Jessica Strid
    Immunobiology Unit, Institute of Child Health, University College London, UK
    Immunology 113:293-303. 2004
    ....
  87. ncbi Evaluation of immunogenicity and protective properties of inactivated poliovirus vaccines: a new surrogate method for predicting vaccine efficacy
    Eugenia M Dragunsky
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA
    J Infect Dis 190:1404-12. 2004
    ..This animal model may be used for the assessment of new IPVs and of combination vaccines containing an IPV component...
  88. ncbi Immune response to two different dosing schedules of the anthrax vaccine precipitated (AVP) vaccine
    Matthew J Hepburn
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Wiltshire, United Kingdom
    Vaccine 25:6089-97. 2007
    ..Extending the interval between the first two AVP vaccinations may produce a stronger immune response, but persistence of this effect needs further study...
  89. ncbi Second thoughts on the flu vaccine
    Nancy Shute
    US News World Rep 137:80. 2004
  90. ncbi Effect of gonadal steroids on proliferative responses and subset alterations in cultured chicken lymphocytes
    T Landsman
    Department of Animal Sciences, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel
    Poult Sci 80:1329-38. 2001
    ..The enhancement of proliferation in response to mitogens by low doses of EB may support this assumption, because the biphasic effects of steroids on gene transcription are well documented...
  91. ncbi [Immunogenicity and long-term persistence of anti-HAV in groups with different attenuated and inactived hepatitis A vaccine dosage]
    X Wang
    Department of Epidemiology, Medical Centre of Fudan University, Shanghai 200032, China
    Zhonghua Liu Xing Bing Xue Za Zhi 22:111-3. 2001
    ..The vaccine, whose titer was 10(6.83)TCID(50), had good immunogenicity and long-term persistence. Booster dose was not needed within short time after initial vaccination...
  92. ncbi A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals
    Joel M Palefsky
    Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    AIDS 20:1151-5. 2006
    ....
  93. pmc Cytosolic entry controls CD8+-T-cell potency during bacterial infection
    Keith S Bahjat
    Cerus Corporation, 2411 Stanwell Drive, Concord, CA 94520, USA
    Infect Immun 74:6387-97. 2006
    ..These results reveal a crucial role for phagosomal escape, not for delivery of antigen to the class I major histocompatibility complex pathway but for establishing the appropriate cellular context during CD8+-T-cell priming...
  94. ncbi Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells
    Yunhua Mei
    Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Immunol Lett 110:29-35. 2007
    ..Such CIH-suppression is dose- and frequency-dependent. The suppressive effect was associated with inhibition of several major inflammatory mediators, pro-inflammatory cytokines and chemokines...
  95. ncbi Generation of phosphatidylinositol-specific antibodies and their characterization
    C L Thomas
    Molecular Neuropathobiology, Imperial Cancer Research Fund, London, UK
    Biochem Soc Trans 27:648-52. 1999
  96. ncbi Competition between MHC class I alleles for cell surface expression alters CTL responses to influenza A virus
    Sophie Tourdot
    Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK
    J Immunol 169:5615-21. 2002
    ..Therefore, certain MHC class I molecules compete with each other for cell surface expression, and the resulting low cell surface expression of specific alleles can lead to a severe reduction in the ability to generate a CTL response...
  97. ncbi Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model
    Niels Hagenaars
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Vaccine 26:6555-63. 2008
    ....
  98. ncbi Induction of apoptosis in human basophils by anti-Fas antibody treatment in vitro
    Kenji Matsumoto
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Arch Allergy Immunol 146:40-6. 2008
    ..In the present study, the expression and function of Fas in human basophils were investigated in vitro...
  99. pmc Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization
    Steevenson Nelson
    Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 4:e1000060. 2008
    ..Thus, in addition to a role in facilitating viral entry, changes in E protein arrangement associated with maturation modulate neutralization sensitivity and introduce an additional layer of complexity into humoral immunity against WNV...
  100. ncbi Differential modulation of interleukin-4 and interleukin-13 secretion from human peripheral blood mononuclear cells
    W Luttmann
    Department of Pneumology, Medical University Clinics, Freiburg i Br, Germany
    Immunol Lett 69:225-31. 1999
    ..In conclusion in this study evidence is provided that IL-4 and IL-13 production are regulated differently which might explain their functional redundancy...
  101. pmc Binding capacity and pathophysiological effects of IgA1 from patients with IgA nephropathy on human glomerular mesangial cells
    Y Wang
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, China
    Clin Exp Immunol 136:168-75. 2004
    ..This suggests that direct interaction between IgA1 and HMC and subsequential pathophysiological responses may play an important role in the pathogenesis for IgAN...

Research Grants76

  1. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
    ....
  2. Role of RALBP1 in Xenobiotic and Radiation Resistance
    Sanjay Awasthi; Fiscal Year: 2008
    ..abstract_text> ..
  3. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
  4. Regulation of murine neonatal Th2 function
    REBECCA D ADKINS; Fiscal Year: 2010
    ..This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..
  5. Novel Antimicrobial Agents Against M. tuberculosis
    MARCUS HORWITZ; Fiscal Year: 2008
    ..mammalian GS, and test the toxicity of the analogs in mice. 2) Test the novel MSO analogs for their capacity to inhibit M. tuberculosis growth in broth culture, in human macrophages, and in guinea pigs. ..
  6. GENETIC TRACING STRATEGIES FOR THE RAT NERVOUS SYSTEM
    Pietro Sanna; Fiscal Year: 2005
    ..The results of the present R21 will contribute to the development and refinement of strategies for the regulated delivery of recombinant tracers and, in follow-up studies, other reporters such as functional biosensors. ..
  7. Development of tumor based antigen presenting cells
    James Riley; Fiscal Year: 2008
    ..Furthermore, these studies will provide the foundation for conducting a clinical trial. ..
  8. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
  9. T-Cell Responses Predict Influenza Risk in Older Adults
    Janet McElhaney; Fiscal Year: 2004
    ..The goal is to define an immunologic test that measures influenza risk, a measure critical to future vaccine development and targeted prophylaxis in older adults. ..
  10. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  11. ACTIVITY OF LYMPHOTACTIN IN CHILDHOOD MALIGNANCY
    Malcolm Brenner; Fiscal Year: 2001
    ..The results obtained with neuroblastoma cells should be generally applicable with other human cancers. ..
  12. Apoptotic nucleosomal DNA and its relevance in SLE
    Roberto Caricchio; Fiscal Year: 2006
    ..abstract_text> ..
  13. COCKROACH ALLERGEN EXPOSURE IN CHILDHOOD ASTHMA
    Sampson Sarpong; Fiscal Year: 2002
    ..Insights gained from this work may lead to preventive measures which may reduce the prevalence and morbidity of childhood asthma. ..
  14. M TUBERCULOSIS GLUTAMINE SYNTHETASE EXPORT & INHIBITION
    MARCUS HORWITZ; Fiscal Year: 2002
    ..tuberculosis glutamine synthetase, they hope to develop more active entities than the parent compound and thereby to develop a new antibiotic against M. tuberculosis. ..
  15. Study of Genetics, Endotoxin and Allergen (SAGE)
    Karin Pacheco; Fiscal Year: 2007
    ....
  16. Effects of Alcohol on the BNST-Cellular Neurobiology
    Pietro Sanna; Fiscal Year: 2005
    ..abstract_text> ..
  17. Mouse Allergen and Asthma Intervention Trial
    Elizabeth Matsui; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. CD200 Expression on Apoptotic DCs and Immune Tolerance
    ROBERT TRUITT; Fiscal Year: 2005
    ..These studies will also provide new insight into a novel molecular pathway that is a target for enhancement of antitumor immunity and for prevention of graft rejection. ..
  19. Regulation of human T cell activation by the CD28 family
    James Riley; Fiscal Year: 2008
    ..The data generated from these studies will better define the relationship between antigen dependent and independent signals and enable new strategies to modulate T cell activation for therapeutic applications. ..
  20. Expansion of HIV infected T cells for immunotherapy
    James Riley; Fiscal Year: 2005
    ..Successful completion of these aims will pave the way for second generation autologous transfusion trials in which the ability of selected subsets of expanded T cells to fight opportunistic and HIV infection(s) can be measured. ..
  21. Therapeutic use of inhibitory DNA sequences in animal models of lupus
    Petar Lenert; Fiscal Year: 2006
    ..Future extension of these studies to humans may lead to the design of novel therapeutic agents for human SLE. [unreadable] [unreadable] [unreadable]..
  22. Phase II trial of 17-AAG in melanoma patients
    Paul Chapman; Fiscal Year: 2007
    ..post-treatment specimens, clinically responding tumors vs. non-responding tumors, and mutant BRAF vs. wild-type BRAF tumors. [unreadable] [unreadable] [unreadable]..
  23. Control of Dendritic Cell Generation and Function by Tumor
    Michael Shurin; Fiscal Year: 2008
    ..Additionally, understanding the mechanisms responsible for DC dysfunction in cancer will serve as a basis for developing novel therapeutic approaches for patients with cancer. ..
  24. Jo-1-specific T Cell Responses in Polymyositis
    DANA ASCHERMAN; Fiscal Year: 2007
    ..These studies are intended to also provide insight concerning the relative roles of altered T cell repertoire and antigen presentation in the expression of Jo-1+ polymyositis. ..
  25. Tracking Mucosal T cells to Commensal Microbes in Vivo
    Massimo Costalonga; Fiscal Year: 2006
    ..The data will be important to human health, establishing a framework to study in vivo mucosal infectious agents and oral vaccines. ..
  26. Inhibition of Macrophage Innate Immunity in Tuberculosis
    WILLIAM NAUSEEF; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. Role of proteoglycans in cocaine dependence
    Pietro Sanna; Fiscal Year: 2004
    ..The elucidation of the neurobiological bases for the transition from non-dependent drug use to addiction is of crucial importance for the development of novel and more effective therapeutic approaches. ..
  28. Neuroprotection and ERK activation by HSV-2 gene ICP10PK
    Laure Aurelian; Fiscal Year: 2007
    ..The studies will provide significant information required for the development of ICP10PK based therapies for the treatment of acute and chronic neurodegenerative diseases that are associated with apoptosis. ..
  29. Targeting FcRs on DCs for Ag-Specific Tolerance
    Adam Boruchov; Fiscal Year: 2008
    ..They should also reveal new insights into the pathophysiology of immune complex-mediated autoimmune diseases. ..
  30. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2007
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  31. M TUBERCULOSIS PHAGOSOME
    MARCUS HORWITZ; Fiscal Year: 2002
    ..tuberculosis to survive and multiply within its host cells and should facilitate the development of new strategies for prevention and treatment of tuberculosis. ..
  32. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
    ..abstract_text> ..
  33. PHARMACOLOGIC T CELL COSTIMULATION IN HIV DISEASE
    Patrick Haslett; Fiscal Year: 2005
    ..If the results support the study hypothesis, a new approach to immune-based therapy for HIV disease will be suggested, as well as a rationale for clinical applications of an oral immune adjuvant drug. ..
  34. Characterization of the M. tuberculosis phagosome
    MARCUS HORWITZ; Fiscal Year: 2007
    ..These experiments will advance our understanding of the cell biology and pathogenic mechanisms of M. tuberculosis and facilitate the development of new strategies to combat tuberculosis. [unreadable] [unreadable]..
  35. Chimeric Adenovirus Vaccine Vectors for HIV/SIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Within the two-year time frame of this award, sufficient data will be generated with candidate chimeric rAd vaccines to justify further vaccine/challenge studies in rhesus monkeys. ..
  36. Mechanisms of acute bowel injury Role of NF-KB
    ISABELLE DE PLAEN; Fiscal Year: 2008
    ..This could prevent its progression toward irreversible intestinal damage and improve the survival of premature infants. [unreadable] [unreadable]..
  37. ALLOGENIC PANCREATIC TUMOR VACCINE CELL LINE
    Elizabeth Jaffee; Fiscal Year: 2003
    ..g. breast and prostate). In addition, characterization of pancreatic tumor antigens may lead to the development of recombinant vaccines that can more efficiently activate antitumor immunity. ..
  38. Haploidentical Allogeneic Transplantation
    Malcolm Brenner; Fiscal Year: 2002
    ..Upon completion of this project, both the maximum safe dose and in vivo fate of the infused non-alloreactive T cells should be clear. ..
  39. Mineralization: Integrins and Focal Adhesion Kinase
    Galen Schneider; Fiscal Year: 2003
    ..This will allow for development of new therapeutic approaches that in turn could lead to novel treatments and tissue-engineered biological applications to increase the quality of life for many patients. ..
  40. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2003
    ....
  41. Differential Gene Expresion in Yersinia pestis
    Kathleen McDonough; Fiscal Year: 2005
    ..Characterization of Y. pestis-specific genes and their proteins in future studies will also identify potential mechanisms by which Y. pestis emerged as a new pathogen distinct from Yptb. ..
  42. TUMOR ASSOCIATED DENDRITIC CELLS
    Michael Shurin; Fiscal Year: 2002
    ....
  43. C REACTIVE PROTEIN IN HOST DEFENSE
    ALEXANDER SZALAI; Fiscal Year: 2002
    ..These studies will increase the understanding of innate host defense mechanisms and their interaction with acquired immunity. ..
  44. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  45. Novel Adenovirus Vaccine Vectors for HIV/SIV
    Dan H Barouch; Fiscal Year: 2010
    ..abstract_text> ..
  46. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2009
    ....
  47. NATURAL HISTORY OF ANAL NEOPLASIA IN HIV INFECTED MEN
    Joel Palefsky; Fiscal Year: 2002
    ....
  48. IDENTIFICATION OF CD8+ T CELL TARGETS ON RENAL CANCER
    Elizabeth Jaffee; Fiscal Year: 2004
    ..abstract_text> ..
  49. THE ROLE OF ALPHA-DEFENSINS IN CYSTIC FIBROSIS LUNG DISE
    L Spencer; Fiscal Year: 2004
    ..Following completion of this training and research, my long-term career interest will remain in the area of pathogenesis and applied clinical intervention of neutrophil-mediated pulmonary disease in pediatric patients. ..
  50. Monocyte / Macrophage TLR4 Expression and Signaling: A Link between Obesity and C
    Brian McFarlin; Fiscal Year: 2008
    ..The primary purpose of this investigation is to determine if obesity status alters TLR4 signaling and/or inflammatory cytokine production in blood monocyte and adipose tissue macrophage. [unreadable] [unreadable] [unreadable]..
  51. COMBINATION CHEMOTHERAPY FOR PANDEMIC INFLUENZA
    Robert Webster; Fiscal Year: 2005
    ....
  52. COACTIVATION SIGNALS REGULATE THYMOCYTE DEVELOPMENT
    David McKean; Fiscal Year: 2005
    ..These analyses will determine how signals integrated from different co-inducer receptors stimulate cross-talk between signaling pathways that affects the outcome of thymocyte selection. ..
  53. Recombinant Sendai Virus as a Novel HIV Vaccine Vector
    KAREN SLOBOD; Fiscal Year: 2004
    ..Studies described in this application may ultimately identify rSV as an effective intranasal vaccine vehicle useful in the prevention of HIV. ..
  54. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  55. 2nd International Conference on Prostate Cancer Research
    David Lubaroff; Fiscal Year: 2002
    ..Selection of the travel awardees will be made by a subcommittee of the Organizing Committee and will be based upon the quality of the research contained in the submitted abstracts. ..
  56. PhaseI/II Clinical Trial of hHB22.7 anti-CD22 Monoclonal Antibody for Lymphoma
    ROBERT O DONNELL; Fiscal Year: 2007
    ..This clinical study is designed to see if hHB22.7 is safe, and promising enough to proceed to additional clinical trials. [unreadable] [unreadable] [unreadable]..
  57. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    ROBERT IRVING contact LEHRER; Fiscal Year: 2010
    ..anthracis spores in mouse models as per the revised Specific Aims. All remaining Aims can be addressed in a two-year time period. PHS ..
  58. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  59. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  60. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  61. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  62. DEFENSINS--ANTIMICROBIAL PEPTIDES OF HUMAN NEUTROPHILS
    Robert Lehrer; Fiscal Year: 2002
    ..The work with murine neutrophils, whose content of endogenous antimicrobial polypeptides differs greatly from those of humans, will provide essential information relevant to the interpretation of murine models of human infection. ..
  63. Motor Neuron Protection through Glutamate Degradation
    Paul Fishman; Fiscal Year: 2002
    ....
  64. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2003
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  65. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  66. HEALTH AND SOCIOECONOMIC CONSEQUENCES OF NSBRI
    Carrie Redlich; Fiscal Year: 2003
    ..This information is critical for the development of interventions to prevent and/or ameliorate the adverse consequences of NSBRI. ..
  67. Microbial Fingerprinting Chip and Automated Analysis
    DON DALY; Fiscal Year: 2003
    ..Because the method and DNA chip is "universal", it may be applicable for the identification of other microorganism, as demonstrated in our preliminary studies with Salmonella, Xanthomonas and E. coli pathogens. ..
  68. Biacore 3000 SPR Instrument
    Robert Lehrer; Fiscal Year: 2004
    ..These include the development of new agents and approaches to prevent and treat infections caused by HIV-1 and other viral pathogens, and fundamental issues related to cell targeting and survival. ..
  69. Pretargeting mouse tumor with anti-PSMA antibody-MORF
    Guozheng Liu; Fiscal Year: 2005
    ..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
  70. Immune Responses to CMV DNA Vaccination
    Mary Wloch; Fiscal Year: 2005
    ..Lastly, we will further the field of measurement of CMV neutralization, which will be critical in the area of maternal-fetal disease prevention and possible universal vaccination. ..
  71. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2001
    ..The long-term objectives for this research are to learn how lipophilin contributes to corneal and conjuctival health, and to explore its potential for creating new diagnostic and therapeutic modalities. ..
  72. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2007
    ..Specific Aim 2 will be realized by a combination of microchemical techniques, including surface plasmon resonance, tandem mass spectrometry, and state-of-the-art lectinomic and peptidomic chemistry. ..
  73. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 2001
    ..S. are sexually transmitted. According to CDC estimates, STDs other than AIDS add 10 billion dollars to the nation's annual health care I costs. The proposed studies could lead to novel approaches for STD prophylaxis. ..
  74. BACTERIAL LIVE VECTOR-BASED VACCINE AGAINST MALARIA
    Myron Levine; Fiscal Year: 2004
    ..falciparum, and by these effects working in concert, we will ultimately be able to prevent disease completely in some subjects and to markedly ameliorate disease severity in others. ..
  75. Immune Pathways as Prerequisites for Adjuvants' Efficacy
    George Hui; Fiscal Year: 2004
    ....
  76. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2008
    ..abstract_text> ..