immunologic cytotoxicity

Summary

Summary: The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.

Top Publications

  1. ncbi Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    Michael R Betts
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
    J Immunol Methods 281:65-78. 2003
  2. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
  3. ncbi Natural killer cells in antiviral defense: function and regulation by innate cytokines
    C A Biron
    Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Immunol 17:189-220. 1999
  4. ncbi Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    D Kagi
    Department of Pathology, University of Zurich, Switzerland
    Nature 369:31-7. 1994
  5. ncbi Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    M A Cooper
    Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH, USA
    Blood 97:3146-51. 2001
  6. ncbi Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
    A Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Annu Rev Immunol 19:197-223. 2001
  7. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
  8. ncbi Lymphocyte-mediated cytotoxicity
    John H Russell
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Immunol 20:323-70. 2002
  9. ncbi Control of effector CD8+ T cell function by the transcription factor Eomesodermin
    Erika L Pearce
    Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 302:1041-3. 2003
  10. ncbi Recognition of viral hemagglutinins by NKp44 but not by NKp30
    T I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Eur J Immunol 31:2680-9. 2001

Detail Information

Publications268 found, 100 shown here

  1. ncbi Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    Michael R Betts
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
    J Immunol Methods 281:65-78. 2003
    ....
  2. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
    ..In addition, we will discuss other cell-surface receptors expressed differentially by human NK-cell subsets and the distinct functional properties of these subsets...
  3. ncbi Natural killer cells in antiviral defense: function and regulation by innate cytokines
    C A Biron
    Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Immunol 17:189-220. 1999
    ....
  4. ncbi Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    D Kagi
    Department of Pathology, University of Zurich, Switzerland
    Nature 369:31-7. 1994
    ..The mice fail to clear lymphocytic choriomeningitis virus and they eliminate fibrosarcoma tumour cells with reduced efficiency. Perforin is therefore a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis...
  5. ncbi Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    M A Cooper
    Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH, USA
    Blood 97:3146-51. 2001
    ..It is proposed that human CD56(bright) NK cells have a unique functional role in the innate immune response as the primary source of NK cell-derived immunoregulatory cytokines, regulated in part by differential monokine production...
  6. ncbi Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
    A Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Annu Rev Immunol 19:197-223. 2001
    ..Indeed, in patients with the X-linked lymphoproliferative disease, the inability to control Epstein-Barr virus infections may be consequent to a major dysfunction of 2B4 that exerts inhibitory instead of activating functions...
  7. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
    ..These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein...
  8. ncbi Lymphocyte-mediated cytotoxicity
    John H Russell
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Immunol 20:323-70. 2002
    ..host disease, but oversuppression of these pathways may also lead to increased viral susceptibility and/or decreased tumor cell killing...
  9. ncbi Control of effector CD8+ T cell function by the transcription factor Eomesodermin
    Erika L Pearce
    Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 302:1041-3. 2003
    ..We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity...
  10. ncbi Recognition of viral hemagglutinins by NKp44 but not by NKp30
    T I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Eur J Immunol 31:2680-9. 2001
    ..221 cells expressing MHC class I proteinsresulted in the abrogation of the inhibition by NK clones expressing high levels of NKp44. In addition, the binding of NKp44 to HA improves the ability of some NK clones to lyse IV infected cells...
  11. ncbi Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells
    Brian A Rabinovich
    Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    J Immunol 170:3572-6. 2003
    ..Our data provide a basis for studying a role for NK cells in T cell regulation...
  12. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
    ..Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction...
  13. ncbi CD107a as a functional marker for the identification of natural killer cell activity
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Massachusetts, USA
    J Immunol Methods 294:15-22. 2004
    ..Cumulatively, the data presented here demonstrate that CD107a is a sensitive marker of NK cell activity...
  14. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  15. ncbi An antimicrobial activity of cytolytic T cells mediated by granulysin
    S Stenger
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 282:121-5. 1998
    ..The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens...
  16. pmc NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo
    Tadepally Lakshmikanth
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Italy
    J Clin Invest 119:1251-63. 2009
    ....
  17. ncbi Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 279:1737-40. 1998
    ..Thus, these molecules may broadly regulate protective responses by the Vdelta1 gammadelta T cells in the epithelium of the intestinal tract...
  18. pmc NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis
    M Vitale
    Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, 16132 Genova, Italy
    J Exp Med 187:2065-72. 1998
    ....
  19. ncbi CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
    Edith M Janssen
    Division of Cellular Immunology and Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 421:852-6. 2003
    ..Our results demonstrate that T-cell help is 'programmed' into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen...
  20. pmc p46, a novel natural killer cell-specific surface molecule that mediates cell activation
    S Sivori
    Istituto di Istologia ed Embriologia Generale, Universita di Genova, Genova, Italy
    J Exp Med 186:1129-36. 1997
    ..Both the unique cellular distribution and functional capability of p46 molecules suggest a possible role in the mechanisms of non-major histocompatibility complex-restricted cytolysis mediated by human NK cells...
  21. ncbi DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes
    A Shibuya
    DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, California 94304 1104, USA
    Immunity 4:573-81. 1996
    ..In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity...
  22. ncbi Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
    Tal I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 6:515-23. 2005
    ..Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction with an activating receptor...
  23. pmc Differential tumor surveillance by natural killer (NK) and NKT cells
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia
    J Exp Med 191:661-8. 2000
    ..This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or alpha-galactosylceramide...
  24. ncbi Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    S Bauer
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 285:727-9. 1999
    ..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses...
  25. ncbi Immune responses in interleukin-2-deficient mice
    T M Kundig
    Institute of Experimental Immunology, University of Zurich, Switzerland
    Science 262:1059-61. 1993
    ..Natural killer cell activity was markedly reduced but inducible. These normal in vivo immune responses in IL-2-deficient mice question the importance of IL-2 as defined by in vitro studies...
  26. pmc Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells
    Diego Piccioli
    IRIS, Department of Immunology, Chiron S p A, 53100 Siena, Italy
    J Exp Med 195:335-41. 2002
    ..Resting NK cells also stimulated autologous DC maturation in a TNF-alpha/contact-dependent manner, however, increasing the NK/DC ratio only led to an enhancement of this effect...
  27. pmc Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 96:6879-84. 1999
    ..These results raise the possibility that an induced expression of MICA/B, by conditions that may be related to tumor homeostasis and growth, could play a role in immune responses against tumors...
  28. ncbi Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor
    Hatice Aldemir
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis Unité Mixte de Recherche 6097, Sophia Antipolis, France
    J Immunol 175:7791-5. 2005
    ..Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-gamma production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions...
  29. pmc Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
    D Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 190:1505-16. 1999
    ..Moreover, we show that NKp30 is encoded by the previously identified 1C7 gene, for which the function and the cellular distribution of the putative product were not identified in previous studies...
  30. pmc Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
    M J Smyth
    Cancer Immunology, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    J Exp Med 193:661-70. 2001
    ..These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma-mediated antimetastatic effects of IL-12 and alpha-GalCer...
  31. ncbi CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells
    R Jacobs
    Department of Clinical Immunology, Hannover Medical School, Hannover, Germany
    Eur J Immunol 31:3121-7. 2001
    ..The poor cytolytic capacity of CD56bright NK cells can be explained by weak ability in forming conjugates with target cells and low contents of perforin and granzyme A in their granules...
  32. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
    ..These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response...
  33. ncbi Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 172:3994-8. 2004
    ..As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors...
  34. doi Modulation of natural killer cell cytotoxicity and cytokine release by the drug glatiramer acetate
    K L Sand
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Cell Mol Life Sci 66:1446-56. 2009
    ..Further, GA inhibited the release of IFN-gamma 24 h but increased the release of TNF-alpha 48 h after incubation with NK cells...
  35. ncbi Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    W E Thierfelder
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 382:171-4. 1996
    ..However, all IL-12 functions tested were disrupted, including the induction of IFN-gamma, mitogenesis, enhancement of natural killer cytolytic function and Th1 differentiation...
  36. ncbi Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramide
    Kazuhiko Yanagisawa
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan
    J Immunol 168:6494-9. 2002
    ..These results suggest that some functions of NKT cells in cancer patients are impaired, and this observation carries significant implications for immunotherapy-based cancer treatments...
  37. pmc Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection
    S Balkow
    Max Planck Institut fur Immunbiologie, 79108 Freiburg, Universitat Freiburg, 79104 Freiburg, Germany
    J Virol 75:8781-91. 2001
    ....
  38. pmc NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
    C Cantoni
    Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, 16132 Genova, Italy
    J Exp Med 189:787-96. 1999
    ..Unlike genes coding for other receptors involved in NK cell triggering or inhibition, the NKp44 gene is on human chromosome 6...
  39. ncbi The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    Michael R Betts
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6407-17. 2004
    ..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response...
  40. ncbi IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells
    Steven J Burgess
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 176:1490-7. 2006
    ..These data indicate that IL-21 is able to channel NK and CD8+ T cell function by altering the expression pattern of activation/costimulatory receptors...
  41. pmc Reciprocal activating interaction between natural killer cells and dendritic cells
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
    J Exp Med 195:327-33. 2002
    ..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation...
  42. ncbi Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity
    Anna K Palucka
    Baylor Institute for Immunology Research, Sammons Cancer Center, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 29:545-57. 2006
    ..Thus, the present results justify the design of larger follow-up studies to assess the clinical response to DC vaccines loaded with killed allogeneic tumor cells in patients with metastatic melanoma...
  43. ncbi NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity
    Per A Albertsson
    Department of Oncology, Sahlgrenska University Hospital, S 41345, Goteborg, Sweden
    Trends Immunol 24:603-9. 2003
    ..New insights into the migration of NK cells, their activation status and production of matrix-degrading proteases might help to overcome this localization defect, with implications for the treatment of human cancer...
  44. ncbi Centrosome polarization delivers secretory granules to the immunological synapse
    Jane C Stinchcombe
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Nature 443:462-5. 2006
    ..These data show that CTLs use a previously unreported mechanism for delivering secretory granules to the immunological synapse, with granule secretion controlled by centrosome delivery to the plasma membrane...
  45. ncbi Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells
    Anthony M Byers
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 171:17-21. 2003
    ..These findings strongly support the concept that a cytotoxic effector-memory CD8(+) T cell population operates in vivo to control this persistent viral infection...
  46. pmc Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity
    Christopher C Stebbins
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Mol Cell Biol 23:6291-9. 2003
    ..Such a mechanism explains how inhibitory receptors can block activating signals induced by different receptors...
  47. ncbi Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes
    H Kojima
    Laboratory of Cellular Immunology, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Immunity 1:357-64. 1994
    ..These data not only confirmed the primary role of perforin but simultaneously revealed a major contribution of a perforin-independent Fas-mediated pathway in antigen-specific cytolysis...
  48. ncbi Phenotypic classification of human CD8+ T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function
    Hiroko Tomiyama
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Honjo, Kumamoto, Japan
    Eur J Immunol 34:999-1010. 2004
    ..Phenotypic analyses of CD8(+) T cells using this classification will enable the characterization of antigen-specific CD8(+) T cells...
  49. ncbi Human natural killer cell receptors and co-receptors
    R Biassoni
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Immunol Rev 181:203-14. 2001
    ..Future studies will clarify whether also the altered expression and/or function of other NK-triggering molecules may represent a possible cause of immunological disorders...
  50. ncbi Deficient expression of NCR in NK cells from acute myeloid leukemia: Evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction
    Cyril Fauriat
    Laboratoire d Immunologie des Tumeurs, Institut National de la Santé et de la Recherche Médicale INSERM Unite Mixté de Recherche UMR 599, Marseille, France
    Blood 109:323-30. 2007
    ..The prognostic value of NCR expression is discussed, and pathophysiologic implication of the NCR phenotype will be further investigated in a larger study...
  51. pmc Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
    A Pessino
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    J Exp Med 188:953-60. 1998
    ..In conclusion, this study reports the first characterization of the molecular structure of a NK-specific receptor involved in the mechanism of NK cell activation during natural cytotoxicity...
  52. pmc Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells
    A Moretta
    Istiuto Nazionale per la Ricerca sul Cancro, Genova Italy
    J Exp Med 182:875-84. 1995
    ..abstract truncated at 400 words)..
  53. ncbi Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2
    Grazia Maria Spaggiari
    Centro di Eccellenza per la Ricerca Biomedica, Biologia e Genetica, Universita di Genova, Genova, Italy
    Blood 111:1327-33. 2008
    ..Finally, we demonstrate that indoleamine 2,3-dioxygenase and prostaglandin E2 represent key mediators of the MSC-induced inhibition of NK cells...
  54. ncbi Rapid CD8+ T cell repertoire focusing and selection of high-affinity clones into memory following primary infection with a persistent human virus: human cytomegalovirus
    Elizabeth K Day
    Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, Hills Road, Cambridge, United Kingdom
    J Immunol 179:3203-13. 2007
    ..Thus, the oligoclonal T cell repertoire against an immunodominant persistent viral epitope is established early in primary infection by the rapid selection of public clonotypes, rather than being a stochastic process...
  55. doi Human and mouse granzyme A induce a proinflammatory cytokine response
    Sunil S Metkar
    Department of Medicine, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA
    Immunity 29:720-33. 2008
    ..Thus, the granule secretory pathway plays an unexpected role in inflammation, with GzmA acting as an endogenous modulator...
  56. ncbi Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Cancer Res 62:6178-86. 2002
    ..Our data suggest that the involvement of NKG2D in natural killer cell-mediated cytotoxicity strictly correlates with the expression and the surface density of MICA and ULBP on target cell tumors of different histotypes...
  57. ncbi Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia
    Regis T Costello
    Unité d Immunologie des Tumeurs Département d Hématologie, Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Blood 99:3661-7. 2002
    ..In few cases, however, this failure appears to involve a mechanism of tumor escape based on down-regulation of ligands relevant for NCR-mediated target cell recognition...
  58. ncbi Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells
    Casper Paludan
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 169:1593-603. 2002
    ..Therefore, adaptive immunity can be directed against Burkitt's lymphoma, and perhaps this role for CD4(+) Th1 cells extends to other tumors that escape MHC class I presentation...
  59. ncbi Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation
    Heather G Shilling
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 101:3730-40. 2003
    ..These results demonstrate that a majority of HLA-matched hematopoietic cell transplantations involve KIR mismatch and reveal differences in NK cell repertoire having potential impact for immune responsiveness and transplantation outcome...
  60. ncbi Natural killer cells and viral infections
    Anthony R French
    Howard Hughes Medical Institute, Rheumatology Division, Box 8045, Washington University Medical Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Immunol 15:45-51. 2003
  61. pmc Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
    Julian Pardo
    Departmento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, E 50009 Zaragoza, Spain
    J Cell Biol 167:457-68. 2004
    ..The ability of gzmA and gzmB to induce multiple independent cell death pathways may be the hosts response to circumvent evasion strategies of pathogens and tumors...
  62. ncbi HIV type 1-infected dendritic cells induce apoptotic death in infected and uninfected primary CD4 T lymphocytes
    Miriam Lichtner
    Antigen Presentation by Dendritic Cell Group, Departement d Immunologie, Institut Cochin, INSERM U567, UMR CNRS 8104, IFR 116 Paris V University, Paris, France
    AIDS Res Hum Retroviruses 20:175-82. 2004
    ..Therefore this new cytotoxic function of DCs may play an important role in innate and adaptive immunity during HIV infection...
  63. ncbi CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism
    D H Canaday
    Division of Infectious Diseases, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Immunol 167:2734-42. 2001
    ..Thus, perforin and CD95-CD95L were not involved in CD4(+) and CD8(+) T cell mediated restriction of MTB growth...
  64. pmc Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
    Yenan T Bryceson
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Exp Med 202:1001-12. 2005
    ..These data show that cytotoxicity by resting NK cells is controlled tightly by separate or cooperative signals from different receptors for granule polarization and degranulation...
  65. ncbi Cytotoxic T lymphocytes: all roads lead to death
    Michele Barry
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Nat Rev Immunol 2:401-9. 2002
    ..So, an understanding of the mechanisms that are used by CTLs to destroy targets and a knowledge of pathogen immune-evasion strategies will provide vital information for the design of new therapies...
  66. ncbi Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction
    Christoph Uherek
    Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, Frankfurt am Main, Germany
    Blood 100:1265-73. 2002
    ..These results demonstrate that efficient retargeting of NK-92 cytotoxicity can be achieved and might allow the generation of potent cell-based therapeutics for the treatment of ErbB2-expressing malignancies...
  67. pmc Evolutionary struggles between NK cells and viruses
    Lewis L Lanier
    Department of Microbiology and Immunology, and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Rev Immunol 8:259-68. 2008
    ..In addition to their participation in the immediate innate immune response against infection, interactions between NK cells and dendritic cells shape the nature of the subsequent adaptive immune response to pathogens...
  68. ncbi The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency
    Claire E Hirst
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    J Immunol 170:805-15. 2003
    ..In conclusion, the presence and subcellular localization of PI-9 in leukocytes and DCs are consistent with a protective role against ectopic or misdirected grB during an immune response...
  69. ncbi Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity
    Jennifer S Y Ma
    Center for Cancer and Immunology, Children s National Medical Center, Children s Research Institute, Washington, DC 20010, USA
    J Immunol 181:4716-22. 2008
    ....
  70. ncbi An activating immunoreceptor complex formed by NKG2D and DAP10
    J Wu
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 285:730-2. 1999
    ..Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors...
  71. ncbi KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential
    Mathias Faure
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 168:6208-14. 2002
    ..Therefore, KIR2DL4 has inhibitory potential in addition to its activating function...
  72. ncbi Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
    Denis Martinvalet
    The CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Immunity 22:355-70. 2005
    ..Superoxide scavengers also block apoptosis by CTLs expressing GzmA and/or GzmB. Therefore, mitochondrial damage is an essential first step in killer cell granule-mediated pathways of apoptosis...
  73. pmc B7H costimulates clonal expansion of, and cognate destruction of tumor cells by, CD8(+) T lymphocytes in vivo
    X Liu
    Department of Pathology and Comprehensive Cancer Center, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Exp Med 194:1339-48. 2001
    ..Taken together, our results reveal that B7H costimulates clonal expansion of, and cognate destruction by CD8(+) T lymphocytes in vivo...
  74. ncbi A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells
    V Screpanti
    Department of Immunology, Wenner Gren Institute, University of Stockholm, Stockholm, Sweden
    J Immunol 167:2068-73. 2001
    ..Moreover, our data indicate that death receptor-mediated apoptosis has a more prominent role in the clearance of NK-sensitive tumors than previously suggested...
  75. ncbi Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana, USA
    Nat Med 9:562-7. 2003
    ..Therefore, upregulation of B7-H1 on MDCs in the tumor microenvironment downregulates T-cell immunity. Blockade of B7-H1 represents one approach for cancer immunotherapy...
  76. ncbi Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity
    Cristina Cerboni
    Department of Experimental Medicine and Pathology, Istituto Pasteur Fondazione Cenci Bolognetti, University La Sapienza, 00161 Rome, Italy
    J Gen Virol 88:242-50. 2007
    ..These findings provide a novel insight into the mechanisms evolved by HIV-1 to escape from the NK-cell response...
  77. ncbi Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    William J Grossman
    Department of Pediatrics, Division of Hematology Oncology, St Louis Children s Hospital, St Louis, MO 63110, USA
    Immunity 21:589-601. 2004
    ..This cytotoxicity is dependent on CD18 adhesive interactions but is independent of Fas/FasL. Our findings suggest that the perforin/granzyme pathway is one of the mechanisms that Treg cells can use to control immune responses...
  78. ncbi Good manufacturing practices production of natural killer cells for immunotherapy: a six-year single-institution experience
    David H McKenna
    Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, University of Minnesota Medical School, Minnesota 55108, USA
    Transfusion 47:520-8. 2007
    ..Herein is a report on the experience of clinical-scale, good manufacturing practices (GMPs) production of NK cells to treat advanced cancer...
  79. ncbi Cutting edge: MHC class II-restricted killing in vivo during viral infection
    Evan R Jellison
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:614-8. 2005
    ..In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets...
  80. ncbi Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa, Chiba, Japan
    Clin Cancer Res 11:7891-900. 2005
    ....
  81. ncbi HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
    V M Braud
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nature 391:795-9. 1998
    ....
  82. ncbi NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46
    G M Spaggiari
    Laboratory of Immunology, National Cancer Research Institute, Genova, Italy
    Eur J Immunol 31:1656-65. 2001
    ..Altogether, these findings strongly suggest that NCR are responsible for the killing of autologous APC through the activation of PI-3 K...
  83. ncbi Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo
    C Y Koh
    Laboratory of Leukocyte Biology, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD, USA
    Blood 97:3132-7. 2001
    ..Therefore, strategies to block inhibitory receptors may be of potential use in increasing the efficacy of immunotherapy. (Blood. 2001;97:3132-3137)..
  84. pmc Response to influenza infection in mice with a targeted disruption in the interferon gamma gene
    M B Graham
    Beirne B, Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908
    J Exp Med 178:1725-32. 1993
    ..In this model of experimental influenza infection, IFN-gamma is not necessary for the development of an effective humoral or cellular immune response to challenge with this respiratory virus...
  85. doi CTL quality and the control of human retroviral infections
    Charles R M Bangham
    Department of Immunology, Imperial College, London, UK
    Eur J Immunol 39:1700-12. 2009
    ..e. in the frequency, phenotype and function or quality of T cells, are the causes or effects - or both - of the variation in the efficiency of virus control...
  86. ncbi T cell defined tumor antigens
    B J Van den Eynde
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Curr Opin Immunol 9:684-93. 1997
    ..The priority is now to demonstrate that immunization against some of these antigens is clinically valuable for antitumor therapy, and the first results of clinical pilot studies are now emerging...
  87. pmc Tumor-specific Th17-polarized cells eradicate large established melanoma
    Pawel Muranski
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Mark O Hatfield Clinical Research Center, Bethesda, MD 20892, USA
    Blood 112:362-73. 2008
    ..This principle should be considered in designing clinical trials involving adoptive transfer-based immunotherapy of human malignancies...
  88. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
    ....
  89. ncbi NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network
    Niels Bovenschen
    Department of Pathology, University Medical Center, Utrecht University, Utrecht, The Netherlands
    J Immunol 180:8184-91. 2008
    ..We conclude that GrM targets major components of the cytoskeleton that likely contribute to NK cell-induced cell death...
  90. pmc Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
    Guido Ferlazzo
    Laboratorio di Immunoterapia Cellulare, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 195:343-51. 2002
    ..We suggest that DCs are able to control directly the expansion of NK cells and that the lysis of immature DCs can regulate the afferent limb of innate and adaptive immunity...
  91. ncbi The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    G B Cohen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 10:661-71. 1999
    ..These results suggest that subpopulations of CTL and NK cells may be uniquely suited for combating HIV...
  92. pmc Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor
    D N Burshtyn
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Immunity 4:77-85. 1996
    ..These data imply that the inhibitory function of p58 is dependent on its tyrosine phosphorylation and on recruitment and activation of HCP...
  93. ncbi Induction of CD16+ CD56bright NK cells with antitumour cytotoxicity not only from CD16- CD56bright NK Cells but also from CD16- CD56dim NK cells
    E Takahashi
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Scand J Immunol 65:126-38. 2007
    ..The proliferation of CD16(+) CD56(bright) NK cells was also induced when PBMC were stimulated with penicillin-treated Streptococcus pyogenes, thus suggesting their role in tumour immunity and bacterial infections...
  94. ncbi Characterization of tumor reactivity of human V gamma 9V delta 2 gamma delta T cells in vitro and in SCID mice in vivo
    Dieter Kabelitz
    Institute of Immunology, Universitätsklinikum Schleswig Holstein Campus Kiel, Germany
    J Immunol 173:6767-76. 2004
    ....
  95. ncbi The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity
    R Biassoni
    Istituto Scientifico Tumori and Centro Biotecnologie Avanzate, Genova, Italy
    Eur J Immunol 29:1014-20. 1999
    ..This high homology together with the presence of a charged amino acid (Arg) in the transmembrane portion suggest that MAR-1 may associate at the cell membrane into a multimeric complex with ITAM containing polypeptides...
  96. pmc The protozoan Neospora caninum directly triggers bovine NK cells to produce gamma interferon and to kill infected fibroblasts
    Preben Boysen
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033 Oslo, Norway
    Infect Immun 74:953-60. 2006
    ....
  97. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction...
  98. doi Bovine natural killer cells
    Preben Boysen
    Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, PO Box 8146 Dep, Oslo NO 0033, Norway
    Vet Immunol Immunopathol 130:163-77. 2009
    ..In this review we will briefly summarize the current understanding of general NK cell biology, and then present the knowledge obtained thus far in the bovine species...
  99. pmc Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity
    Claire Dunn
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA
    J Exp Med 197:1427-39. 2003
    ..The intracellular sequestration of NKG2D ligands by UL16 represents a novel HCMV immune evasion mechanism to add to the well-documented viral strategies directed against antigen presentation by classical MHC molecules...
  100. ncbi Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
    R M Pitti
    Department of Molecular Oncology, Molecular Biology, and Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 396:699-703. 1998
    ..Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL...
  101. ncbi Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling
    Rajani Ravi
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 66:1730-9. 2006
    ..direct activation of caspase-3/-7 by granzyme B or Apo2L/TRAIL, and restores their susceptibility to immunologic cytotoxicity. These findings identify an important mechanism by which cancers evade elimination by immune effector ..

Research Grants165 found, 100 shown here

  1. CYTOTOXIC MECHANISMS IN CUTANEOUS DISEASE
    David Norris; Fiscal Year: 2001
    ..We have found that the epidermis is intrinsically resistant to immunologic cytotoxicity, due in large part to resistance of basal keratinocytes and melanocytes to apoptosis induced by ..
  2. CYTOTOXIC MECHANISMS IN CUTANEOUS DISEASE
    David Norris; Fiscal Year: 1990
    The objective of this project is to study immunologic cytotoxicity as a mechanism of discrete cellular lysis in cutaneous disease, with particular emphasis on antibody mediated mechanisms of lysis, especially antibody dependent cellular ..
  3. Using Targeted Immunotherapy to Enhance Chemotherapy of Colorectal Cancer
    Atul Bedi; Fiscal Year: 2009
    ..factor- related apoptosis-inducing ligand (Apo2L/TRAIL), a key effector of NK cell- and T cell-mediated immunologic cytotoxicity, to induce p53-independent apoptosis of colon cancer cells...
  4. Using Targeted Immunotherapy to Enhance Chemotherapy of Colorectal Cancer
    Atul Bedi; Fiscal Year: 2010
    ..factor- related apoptosis-inducing ligand (Apo2L/TRAIL), a key effector of NK cell- and T cell-mediated immunologic cytotoxicity, to induce p53-independent apoptosis of colon cancer cells...
  5. Using Targeted Immunotherapy to Enhance Chemotherapy of Colorectal Cancer
    Atul Bedi; Fiscal Year: 2007
    ..factor- related apoptosis-inducing ligand (Apo2L/TRAIL), a key effector of NK cell- and T cell-mediated immunologic cytotoxicity, to induce p53-independent apoptosis of colon cancer cells...
  6. CYTOTOXIC MECHANISMS IN CUTANEOUS DISEASE
    David Norris; Fiscal Year: 2007
    ..major objective of this grant over the past 20 years has been to study key aspects of the mechanisms of immunologic cytotoxicity in skin disease...
  7. CYTOTOXIC MECHANISMS IN CUTANEOUS DISEASE
    David Norris; Fiscal Year: 1993
    ..on the surface of epidermal keratinocytes is a prerequisite for leukocyte/keratinocyte attachment and immunologic cytotoxicity of keratinocytes...
  8. ACTIVITY OF EXPANDED GAMMA/DELTA T CELLS
    Michael Verneris; Fiscal Year: 2005
    ..Thus, the candidate will acquire the skills to secure a faculty position as a pediatric bone marrow transplantation clinical-scientist...
  9. Diversification of Cytotoxic Effector Cells Via LPS-activated DCs
    Anna Karolina Palucka; Fiscal Year: 2010
    ..Vaccination with DCs could become an option for patients with earlier disease stages. ..
  10. Cellular Immunity to BK Virus
    Simon Lacey; Fiscal Year: 2005
    ..Such information may be useful in guiding clinical management, and lay the foundation for possible future vaccines. ..
  11. Criteria for Protective Immunity to BK virus in Kidney Transplant Recipients
    Simon Lacey; Fiscal Year: 2007
    ..Information from the proposed study may allow identification of patients at risk of progression from BKV reactivation to clinical BKV disease and guide therapeutic interventions. ..
  12. INTRAEPITHELIAL LYMPHOCYTES RELATION TO EPITHELIAL CELLS
    Ellen Ebert; Fiscal Year: 1992
    ..Human IEL are a little-understood compartment of lymphocytes whose interactions with EC have never been studied. Yet, these interactions may be critical to the mucosal immune network...
  13. Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T Cells
    Anna Karolina Palucka; Fiscal Year: 2010
    ..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..
  14. Mice with Human Dendritic Cells to Test Vaccine Potency
    A Palucka; Fiscal Year: 2004
    ..The experiments proposed here would lay ground for further use of SCID-hu/DCs mice to study other vaccines and demonstrate development of protective immunity upon in vivo rechallenge. ..
  15. MOLECULAR MECHANISMS OF HIV IMMUNE EVASION
    Kathleen Collins; Fiscal Year: 2003
    ..In this proposal, we present experiments that will shed more light on the molecular mechanism of nef-mediated MHC class I downmodulation. ..
  16. Molecular Mechanisms of HIV's Immune Evasion
    Kathleen L Collins; Fiscal Year: 2010
    ..This grant proposal aims to more fully understand the viral mechanisms for immune escape and viral persistence in order to eradicate infected cells, cure disease and prevent new infection. ..
  17. Molecular Mechanisms of HIV Disease Pathogenesis
    Kathleen Collins; Fiscal Year: 2007
    ..This proposal is relevant to the mission of NIH in that it seeks to understand basic mechanisms of how HIV establishes a chronic infection. This work has the potential to have a significant impact on public health. ..
  18. Molecular Mechanisms of HIV's Immune Evasion
    Kathleen Collins; Fiscal Year: 2007
    ..Studies are proposed to better understand the detailed molecular mechanism of MHC-I downmodulation. These studies should aid in the development of inhibitors that disrupt HIV immune evasion. ..
  19. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
    ..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
  20. Suppressor CD8+ T cells in HIV infection
    Mohamed Elrefaei; Fiscal Year: 2007
    ..The expression by the IL- 10+ CD8+ Ts of various markers associated with regulatory T cells, such as CD25, FoxpS, CTLA-4 will also be assessed. ..
  21. Molecular Mechanisms of HIV Disease Pathogenesis
    Kathleen L Collins; Fiscal Year: 2011
    ..This proposal is relevant to the mission of NIH in that it seeks to understand basic mechanisms of how HIV establishes a chronic infection. This work has the potential to have a significant impact on public health. ..
  22. Dendritic Cells and Breast Cancer Immunity
    A Palucka; Fiscal Year: 2004
    ..Overall, this proposal will permit us to demonstrate that efficient breast cancer immunity can be generated and used to reject the tumor thus permitting development of novel treatment modalities in breast cancer. ..
  23. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  24. Molecular Mechanisms of HIV Disease Pathogenesis
    Kathleen Collins; Fiscal Year: 2003
    ..A complete understanding of the variables that affect CTL recognition of infected cells should help facilitate the development a vaccine and new approaches to the treatment of AIDS. ..
  25. CD8 T CELL ACTIVATION AND MIGRATION IN VIVO
    Leo Lefrancois; Fiscal Year: 2011
    ..Memory T cells are essential to provide protection against many infections so this research has substantial impact on understanding immunity and vaccine design. ..
  26. IMMUNOBIOLOGY OF INTESTINAL INTRAEPITHELIAL LYMPHOCYTES
    Leo Lefrancois; Fiscal Year: 1993
    ..The experiments proposed will significantly further our knowledge in this area...
  27. Mechanisms of Trichothecene Toxicity
    James Pestka; Fiscal Year: 2007
    ..abstract_text> ..
  28. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2007
    ..abstract_text> ..
  29. Role of IL-15 in CD8 T Cell Development and Response
    Leo Lefrancois; Fiscal Year: 2006
    ..These studies will provide a comprehensive analysis of the role of lL-15 in regulation of CD8 T cells. ..
  30. CHEMISTRY AND DEVELOPMENT OF TRANSPLANTATION ANTIGENS
    Michael Edidin; Fiscal Year: 2006
    ..Chaperones and export carriers, tapasin and BAP31 will also be tagged with FP as will viral proteins, the US3 protein of HCMV, and the MCMV proteins m4(p34) and m152. ..
  31. Influence of Lactation on Postpartum Stress and Immunity
    MAUREEN EDITH GROER; Fiscal Year: 2010
    ..The immunology and endocrinology of the postpartum provides a lens through which to study autoimmune disease, as the postpartum is a critical period for development or exacerbation of many autoimmune diseases. ..
  32. Mechanisms Of Trichothecene Immunotoxicity
    James Pestka; Fiscal Year: 2004
    ..Over the long term, this research will help characterize hazards associated with trichothecene exposure that can be used in human risk assessment. ..
  33. CD4 aptamer-siRNA chimeras to prevent HIV transmission
    Judy Lieberman; Fiscal Year: 2010
    ..We propose to investigate in this proposal a novel method for overcoming the major obstacle to extending the promising results for inhibiting HSV-2 transmission to HIV, namely getting small RNAs into the immune cells that HIV infects. ..