graft rejection

Summary

Summary: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.

Top Publications

  1. ncbi Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
  2. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
  3. ncbi Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
    C Wiebe
    Department of Medicine and Immunology, University of Manitoba, Canada
    Am J Transplant 12:1157-67. 2012
  4. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
  5. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004
  6. ncbi Regulatory T cells in transplantation tolerance
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Nat Rev Immunol 3:199-210. 2003
  7. ncbi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
  8. pmc Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting
    Alma J Nauta
    Laboratory of Experimental Hematology, Department of Hematology, D2 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Blood 108:2114-20. 2006
  9. ncbi Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
  10. pmc Tolerogenic dendritic cells and their role in transplantation
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
    Semin Immunol 23:252-63. 2011

Detail Information

Publications385 found, 100 shown here

  1. ncbi Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
    ..Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens...
  2. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
    ..The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known...
  3. ncbi Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
    C Wiebe
    Department of Medicine and Immunology, University of Manitoba, Canada
    Am J Transplant 12:1157-67. 2012
    ....
  4. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
    ..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
  5. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004
    ..However, the etiology of this concerning trend for worse death censored graft survival in recent years will warrant further investigation...
  6. ncbi Regulatory T cells in transplantation tolerance
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Nat Rev Immunol 3:199-210. 2003
    ....
  7. ncbi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
    ....
  8. pmc Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting
    Alma J Nauta
    Laboratory of Experimental Hematology, Department of Hematology, D2 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Blood 108:2114-20. 2006
    ..These properties may be of therapeutic value in allogeneic transplantation to prevent graft rejection and to prevent and treat graft-versus-host disease...
  9. ncbi Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
    ..This prospective cohort indicates that many actual failures after indication biopsies manifest phenotypic features of antibody-mediated or mixed rejection and also underscores the major role of nonadherence...
  10. pmc Tolerogenic dendritic cells and their role in transplantation
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
    Semin Immunol 23:252-63. 2011
    ..Evaluation of technical and therapeutic logistic issues is an important next step prior to the application of tolerogenic DC in clinical organ transplantation...
  11. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
    ..With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure...
  12. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
    ....
  13. ncbi Diabetes mellitus after kidney transplantation in the United States
    Bertram L Kasiske
    The United States Renal Data System Coordinating Center, Minneapolis, MN, USA
    Am J Transplant 3:178-85. 2003
    ..It is a strong, independent predictor of graft failure and mortality. Efforts should be made to minimize the risk of this important complication...
  14. pmc Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation
    Carmen Lefaucheur
    Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 21:1398-406. 2010
    ..Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients...
  15. ncbi Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance
    W Ge
    Department of Surgery, The University of Western Ontario, London, Ontario, Canada
    Am J Transplant 9:1760-72. 2009
    ..This study supports the clinical applicability of MSCs in transplantation...
  16. ncbi Immunosuppressive drugs for kidney transplantation
    Philip F Halloran
    Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    N Engl J Med 351:2715-29. 2004
  17. ncbi Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection
    Susan Stewart
    Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 26:1229-42. 2007
    ..This consensus revision of the working formulation was approved by the ISHLT board of directors in April 2007...
  18. ncbi Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection
    Susan Stewart
    International Society for Heart and Lung Transplantation, Addison, Texas, USA
    J Heart Lung Transplant 24:1710-20. 2005
    ..Technical considerations in biopsy processing are also addressed. This consensus revision of the Working Formulation was approved by the ISHLT Board of Directors in December 2004...
  19. ncbi A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
    A Durrbach
    Bicetre Hospital, Kremlin Bicetre, IFRNT, Universite Paris Sud, France
    Am J Transplant 10:547-57. 2010
    ....
  20. ncbi Antibody-mediated renal allograft rejection: diagnosis and pathogenesis
    Robert B Colvin
    Pathology Department, Thier 831, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Soc Nephrol 18:1046-56. 2007
    ..Clinical trials will be needed to ascertain the optimal treatment for the newly appreciated conditions chronic humoral rejection and accommodation...
  21. ncbi Incidence and impact of de novo donor-specific alloantibody in primary renal allografts
    Matthew J Everly
    Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA
    Transplantation 95:410-7. 2013
    ..This report details the dnDSA incidence and actual 3-year post-dnDSA graft outcomes...
  22. ncbi Tacrolimus once daily (ADVAGRAF) versus twice daily (PROGRAF) in de novo renal transplantation: a randomized phase III study
    B K Krämer
    V Medizinische Klinik, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Am J Transplant 10:2632-43. 2010
    ..Overall results obtained with either Tacrolimus QD or BID, without antibody induction, were good, supporting use of the once-daily formulation as an effective alternative to the established twice-daily formulation...
  23. ncbi Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model
    Paolo Sbano
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Siena, Italy
    Arch Dermatol Res 300:115-24. 2008
    ..Results of our study in a rat tissue transplantation model demonstrated a possible immunogenic role for donor (allogeneic) MSC, confirming the need of adequate preclinical experimentation before clinical use...
  24. ncbi Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')
    K Solez
    University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:518-26. 2007
    ..Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference...
  25. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  26. ncbi Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate
    F C Popp
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee, 11 93053 Regensburg, Germany
    Transpl Immunol 20:55-60. 2008
    ..In summary, we demonstrate that MSC constitute a promising tool for induction of non-responsiveness in solid organ transplantation that warrants further investigation in clinical trials...
  27. ncbi Mast cells are essential intermediaries in regulatory T-cell tolerance
    Li Fan Lu
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Nature 442:997-1002. 2006
    ..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
  28. ncbi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  29. ncbi Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection
    Lorraine C Racusen
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 3:708-14. 2003
    ..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
  30. pmc Predominance of intraglomerular T-bet or GATA3 may determine mechanism of transplant rejection
    Qiquan Sun
    Research Institute of Nephrology, Jinling Hospital, 305 East Zhong Shan Road, Nanjing 210002, China
    J Am Soc Nephrol 22:246-52. 2011
    ..In summary, predominance of intraglomerular T-bet expression correlates with antibody-mediated rejection and resistance to steroid treatment...
  31. ncbi Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients
    Hans H Hirsch
    Division of Infectious Diseases, University of Basel, Basel, Switzerland
    N Engl J Med 347:488-96. 2002
    ....
  32. ncbi A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants
    B Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 12:1168-79. 2012
    ..Thus any degree of microcirculation inflammation in late kidney transplant biopsies strongly indicates presence of DSA and predicts progression to graft failure...
  33. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
    ..We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy...
  34. ncbi Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs
    Clara Crescioli
    Center for Research Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Exp Cell Res 314:1337-50. 2008
    ....
  35. ncbi Posttransplant de novo donor-specific hla antibodies identify pediatric kidney recipients at risk for late antibody-mediated rejection
    F Ginevri
    Pediatric Nephrology, Istituto G Gaslini, Genova, Italy
    Am J Transplant 12:3355-62. 2012
    ..005). In our pediatric cohort, DSA identify patients at risk of renal dysfunction, AMR and graft loss; treatment started at Ab emergence might prevent AMR occurrence and/or progression to graft failure...
  36. pmc Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
    L Fan
    Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
    Am J Transplant 11:911-22. 2011
    ..In addition, these data indicate that neutralizing IL-17A or augmenting IL-10 could be therapeutic interventions to prevent OB...
  37. pmc CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    A D Kirk
    Division of Transplantation, University of Wisconsin Hospital, Madison, WI 53792, USA
    Proc Natl Acad Sci U S A 94:8789-94. 1997
    ....
  38. pmc Interleukin-17 promotes early allograft inflammation
    Victoria Gorbacheva
    Department of Immunology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Pathol 177:1265-73. 2010
    ..Targeting the IL-17 signaling network in conjunction with other graft-prolonging therapies may decrease this injury and improve the survival of transplanted organs...
  39. ncbi Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 87:1681-8. 2009
    ..The aims of this study were to investigate to which extent HLA-DSA detected by SAFB represent a risk for antibody-mediated rejection (AMR) and diminished allograft survival, and to define HLA-DSA characteristics predictive for AMR...
  40. ncbi All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies
    Po Chang Lee
    Department of Surgery, Medical College, University Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan, Taiwan 704
    Transplantation 74:1192-4. 2002
    ..Recent studies show that almost all patients who have rejected a kidney transplant had human leukocyte antigen (HLA) antibodies. In this study, we sought to determine whether patients develop HLA antibodies before chronic rejection...
  41. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    Rapamycin is an immunosuppressive compound that is currently used to prevent acute graft rejection in humans. In addition, rapamycin has been shown to allow operational tolerance in murine models...
  42. ncbi The Banff 2007 working classification of skin-containing composite tissue allograft pathology
    L C Cendales
    Emory Transplant Center, Emory University, Atlanta, GA, USA
    Am J Transplant 8:1396-400. 2008
    ..This classification refines proposed schemas, represents international consensus on this topic, and establishes a working collective classification system for CTA reporting of rejection in skin-containing CTAs...
  43. ncbi Composite tissue allotransplantation: classification of clinical acute skin rejection
    Linda C Cendales
    Office of the Clinical Director, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Department of Health and Human Resources, Bethesda, MD 20892 1102, USA
    Transplantation 81:418-22. 2006
    ..However, a systematic examination of this process has not been performed, and there are no standardized criteria for the description of severity or type of rejection...
  44. ncbi Messenger RNA for FOXP3 in the urine of renal-allograft recipients
    Thangamani Muthukumar
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 353:2342-51. 2005
    ..The outcome of renal transplantation after an episode of acute rejection is difficult to predict, even with an allograft biopsy...
  45. ncbi Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production
    Stephen R Mattarollo
    The University of Queensland Diamantina Institute, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    J Immunol 184:1242-50. 2010
    ..Suppression of graft rejection is associated with the accumulation of CD1d(hi)-expressing CD11c(+)F4/80(hi) myeloid cells in hyperplastic ..
  46. ncbi Pediatric cardiac transplantation in children with high panel reactive antibody
    Jeffrey P Jacobs
    The Congenital Heart Institute of Florida, All Children s Hospital, University of South Florida, St Petersburg, Florida, USA
    Ann Thorac Surg 78:1703-9. 2004
    ..We retrospectively reviewed our management strategy and outcome data for children undergoing heart transplantation with high PRA (> 10%)...
  47. ncbi Low levels of human leukocyte antigen donor-specific antibodies detected by solid phase assay before transplantation are frequently clinically irrelevant
    Vincent Aubert
    Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Hum Immunol 70:580-3. 2009
    ..The only AHR episode occurred in a recipient with pretransplantation DSA. More work should be performed to better delineate the precise clinical significance of detecting low titers of DSA before transplantation...
  48. pmc IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants
    William J Burlingham
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Clin Invest 117:3498-506. 2007
    ..These data suggest that while alloimmunity initiates lung transplant rejection, de novo autoimmunity mediated by col(V)-specific Th17 cells and monocyte/macrophage accessory cells ultimately causes progressive airway obliteration...
  49. ncbi Antibodies against MICA antigens and kidney-transplant rejection
    Yizhou Zou
    Transplantation Immunology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8886, USA
    N Engl J Med 357:1293-300. 2007
    ..We sought to determine whether an immune response to MICA antigens might play a role in the failure of kidney allografts...
  50. ncbi Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection
    Che Chuan Loong
    Department of Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Pathol 197:322-32. 2002
    ..These results demonstrate that hRECs exposed to IL-17 can produce inflammatory mediators with the potential to stimulate early alloimmune responses, which may also serve to give warning of acute renal allograft rejection...
  51. pmc A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy
    Xueli Yuan
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:3133-44. 2008
    ..These results have important implications for the development of novel therapies to target this intractable problem in clinical solid organ transplantation...
  52. ncbi Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
    Leo E Otterbein
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
    Nat Med 9:183-90. 2003
    ..These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent...
  53. ncbi Xenotransplantation: current status and a perspective on the future
    Yong Guang Yang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Rev Immunol 7:519-31. 2007
    ..This Review highlights the major obstacles impeding the translation of xenotransplantation into clinical therapies and the potential solutions, providing a perspective on the future of clinical xenotransplantation...
  54. ncbi Gene-expression profiling for rejection surveillance after cardiac transplantation
    Michael X Pham
    Stanford University Medical Center, Stanford, California, USA
    N Engl J Med 362:1890-900. 2010
    ..However, this procedure is uncomfortable, and there are risks associated with it. Gene-expression profiling of peripheral-blood specimens has been shown to correlate with the results of an endomyocardial biopsy...
  55. pmc Proteomic signatures in plasma during early acute renal allograft rejection
    Gabriela V Cohen Freue
    Prevention of Organ Failure PROOF Centre of Excellence, Vancouver, British Columbia, Canada
    Mol Cell Proteomics 9:1954-67. 2010
    Acute graft rejection is an important clinical problem in renal transplantation and an adverse predictor for long term graft survival...
  56. ncbi Inferior kidney allograft outcomes in patients with de novo donor-specific antibodies are due to acute rejection episodes
    James E Cooper
    Division of Renal Diseases and Hypertension, Transplant Center, University of Colorado Denver, Aurora, CO 80045, USA
    Transplantation 91:1103-9. 2011
    ..We evaluated the effectiveness of a prospective DSA screening protocol in identifying kidney and kidney/pancreas recipients at risk for poor graft outcomes...
  57. ncbi Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance?
    Radhika Chadha
    Transplantation 91:939-45. 2011
    ..Despite accumulating evidence, the precise impact of Th17 cells on transplant rejection and the induction of tolerance require further clarification...
  58. ncbi Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure
    Kazuo Mizutani
    Terasaki Foundation Laboratory, Los Angeles, California, USA
    Am J Transplant 5:2265-72. 2005
    ..These antibodies found in the peripheral circulation, were not necessarily donor-specific, but their association with failure is consistent with a causality hypothesis...
  59. pmc Heterologous immunity provides a potent barrier to transplantation tolerance
    Andrew B Adams
    Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 111:1887-95. 2003
    ..These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function...
  60. ncbi Once-daily extended-release versus twice-daily standard-release tacrolimus in kidney transplant recipients: a systematic review
    Elaine T L Ho
    Centre for Transplant and Renal Research, Westmead Hospital, Westmead, New South Wales, Australia 2145
    Transplantation 95:1120-8. 2013
    ..We aimed to identify, appraise, and synthesize the current evidence comparing the relative safety and efficacy of the recently introduced daily versus standard twice-daily tacrolimus administration...
  61. pmc Urinary-cell mRNA profile and acute cellular rejection in kidney allografts
    Manikkam Suthanthiran
    Weill Cornell Medical College, New York, NY, USA
    N Engl J Med 369:20-31. 2013
    ..The standard test for the diagnosis of acute rejection in kidney transplants is the renal biopsy. Noninvasive tests would be preferable...
  62. ncbi System for integrated adherence monitoring: real-time non-adherence risk assessment in pediatric kidney transplantation
    Ahna L H Pai
    Center for the Promotion of Treatment Adherence and Self Management, Cincinnati Children s Hospital Medical, Cincinnati, OH 45229 3039, USA
    Pediatr Transplant 16:329-34. 2012
    ..However, the best methods for using self-report and trough levels to predict non-adherence likely differ based on the medication for which adherence is being assessed...
  63. ncbi Monitoring nonadherence and acute rejection with variation in blood immunosuppressant levels in pediatric renal transplantation
    Margaret Hsiau
    Mattel Children s Hospital, UCLA, CA, USA
    Transplantation 92:918-22. 2011
    ..Acute rejection associated with medication nonadherence is a major cause of allograft loss in pediatric kidney transplant patients. There is currently no reliable method to detect medication nonadherence and prevent allograft rejection...
  64. pmc MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA
    M J Scian
    Surgery Biostatistics Human and Molecular Genetics Pathology, Virginia Commonwealth University, Richmond, VA, USA
    Am J Transplant 11:2110-22. 2011
    ..A characteristic miRNA signature for IF/TA that correlates with paired urine samples was identified. These results support the potential use of miRNAs as noninvasive markers of IF/TA and for monitoring graft function...
  65. ncbi Interleukin-17 positive cells accumulate in renal allografts during acute rejection and are independent predictors of worse graft outcome
    Unsal Yapici
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Transpl Int 24:1008-17. 2011
    ..We conclude that intragraft IL-17(+) cell count during acute allograft rejection could have an additional value for predicting late graft dysfunction...
  66. ncbi Long-term kinetics of cytokine responses in human tears after penetrating keratoplasty
    Mariann Fodor
    Department of Ophthalmology, Medical and Health Sciences Centre, Faculty of Medicine, University of Debrecen, Hungary
    J Interferon Cytokine Res 29:375-80. 2009
    ..The enhanced release of IL-6 and IL-8 into the tears of patients with corneal graft rejection concomitant with decreased concentrations of IL-10, TNF-alpha, and IL-12p70 may possibly serve as an ..
  67. pmc Identification and classification of acute cardiac rejection by intragraft transcriptional profiling
    Cecile T J Holweg
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Circulation 123:2236-43. 2011
    ..Intragraft gene expression profiling may be a way to complement histological evaluation...
  68. ncbi Immunosuppression: evolution in practice and trends, 1994-2004
    H U Meier-Kriesche
    University of Florida, Gainesville, FL, USA
    Am J Transplant 6:1111-31. 2006
    ..The percentage of patients treated for acute rejection during the first year following transplantation has continued to decline, reaching 13% for those who received a kidney in 2003, 48% of which cases were treated with antibodies...
  69. ncbi Graft rejection following descemet stripping automated endothelial keratoplasty: features, risk factors, and outcomes
    Elaine I Wu
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, 10003, USA
    Am J Ophthalmol 153:949-957.e1. 2012
    To investigate the clinical features, risk factors, and treatment outcomes following immunologic graft rejection in eyes that have undergone Descemet stripping automated endothelial keratoplasty (DSAEK).
  70. ncbi Significance of complement split product C4d in ABO-compatible liver allograft: diagnosing utility in acute antibody mediated rejection
    Sharif Ali
    Henry Ford Hospital, USA
    Transpl Immunol 26:62-9. 2012
    ..Unlike other solid organ allografts, C4d-positive staining is not a rugged indicator of humoral rejection, thus, interpretation should be done with caution to avoid diagnostic dilemmas...
  71. pmc Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages
    Kentaro Ide
    Department of Surgery, Division of Frontier Medical Science, Hiroshima University, Hiroshima 734 8551, Japan
    Proc Natl Acad Sci U S A 104:5062-6. 2007
    ..Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection...
  72. ncbi Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation
    Francis L Weng
    Center for Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 923 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Am Soc Nephrol 16:1839-48. 2005
    ..The transplant center and dosing frequencies of immunosuppressive medications are associated with adherence and explain a substantial proportion of the race-adherence relationship...
  73. ncbi Immunological issues in clinical composite tissue allotransplantation: where do we stand today?
    Emmanuel Morelon
    Department of Transplantation, Edouard Herriot Hospital Group, HCL, Lyon, France
    Transplantation 93:855-9. 2012
    ..The increasing number of patients and the longer follow-up hopefully will allow answering these questions...
  74. pmc Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection
    Byung H Chung
    Convergent Research Consortium for Immunological Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Immunology 136:344-51. 2012
    ..The FOXP3/IL-17 ratio is a useful indicator for representing the severity of tissue injury, allograft dysfunction and for predicting the clinical outcome of ATCMR...
  75. pmc Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice
    Shounan Yi
    Centre for Transplant and Renal Research, Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia
    Diabetes 61:1180-91. 2012
    ....
  76. ncbi Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donor-specific antibodies (DSA)
    A Loupy
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, APHP, Paris, France
    Am J Transplant 11:56-65. 2011
    ..However, C4d may not be a sufficiently sensitive indicator of activity, MI and DSA being more robust predictors of bad outcome...
  77. ncbi De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy
    Michelle Willicombe
    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, UK
    Transplantation 94:172-7. 2012
    ..The aim of this study was to establish the incidence and outcomes after the development of DQ DSAbs along with the impact of class II HLA mismatch on their development...
  78. pmc Partial therapeutic response to Rituximab for the treatment of chronic alloantibody mediated rejection of kidney allografts
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transpl Immunol 27:107-13. 2012
    ..Therefore, no efficacious therapy to treat CAMR is presently available to prevent the progression of CAMR to kidney allograft failure...
  79. pmc Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection
    Pamela M Kimball
    Department of Transplant Surgery, Virginia Commonwealth University Health Systems, Richmond, Virginia 23219, USA
    Kidney Int 79:1131-7. 2011
    ..Thus, systematic assessment of longitudinal changes in alloantibody levels, either by FCXM or solid-phase assay, can help identify patients at greater risk of developing CR...
  80. ncbi Diagnosis and prevention of chronic kidney allograft loss
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    Lancet 378:1428-37. 2011
    ..Strategies to maintain transplant function and improve long-term graft survival are important goals of translational research...
  81. ncbi High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response
    Lihua Duan
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Lab Invest 91:43-53. 2011
    ....
  82. pmc Fibrosis with inflammation at one year predicts transplant functional decline
    Walter D Park
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Nephrol 21:1987-97. 2010
    ..Early interventions aimed at altering rejection-like inflammation may improve long-term survival of kidney allografts...
  83. ncbi Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circulation 124:S187-96. 2011
    ..However, the precise role in allograft rejection remains uncertain. In the present study, we investigated the role of IL-17 in acute allograft rejection using IL-17-deficient mice...
  84. ncbi The histology of solitary renal allografts at 1 and 5 years after transplantation
    M D Stegall
    Von Liebig Transplant Center, Division of Transplantation Surgery, Division of Nephrology and Hypertension, Department of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 11:698-707. 2011
    ..These results in the recent era of transplantation demonstrate fewer, less severe and less progressive chronic histologic changes in the first 5 years after transplantation than previously reported...
  85. doi Effect on kidney graft survival of reducing or discontinuing maintenance immunosuppression after the first year posttransplant
    Gerhard Opelz
    Transplantation 86:371-6. 2008
    ..Data are scarce concerning the impact of maintenance immunosuppression dose reductions posttransplant...
  86. ncbi The T helper 17-regulatory T cell axis in transplant rejection and tolerance
    Peter Mitchell
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London, UK
    Curr Opin Organ Transplant 14:326-31. 2009
    ..However, Tregs can be subverted by inflammatory conditions, resulting in a T helper 17 (Th17) cell response. This review looks at the relationship between Tregs and Th17 cells...
  87. pmc Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure
    R B Mannon
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Transplant 10:2066-73. 2010
    ..Phenotypic characterization of these inflammatory cells and appropriate treatment may ameliorate late allograft failure...
  88. ncbi Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:341-58. 2010
    ..Although this consensus report does not evaluate the final role of MPA TDM in transplantation, it seeks to examine the current scientific evidence for concentration-controlled dosing of MPA...
  89. ncbi Predicting subsequent decline in kidney allograft function from early surveillance biopsies
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnnesota, USA
    Am J Transplant 5:2464-72. 2005
    ..In conclusion, inflammation and glomerulopathy 1 year post-transplant predict loss of graft function and graft failure independently of function and other variables...
  90. pmc Universal noninvasive detection of solid organ transplant rejection
    Thomas M Snyder
    Department of Applied Physics, Stanford University, Stanford, The Howard Hughes Medical Institute, CA 94305, USA
    Proc Natl Acad Sci U S A 108:6229-34. 2011
    ..This noninvasive test holds promise for replacing the endomyocardial biopsy in heart transplant recipients and may be applicable to other solid organ transplants...
  91. ncbi Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
    Howard J Eisen
    Section of Cardiology, Temple University, Philadelphia, PA 19140, USA
    N Engl J Med 349:847-58. 2003
    ..We conducted a randomized, double-blind, clinical trial comparing everolimus with azathioprine in recipients of a first heart transplant...
  92. ncbi The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection
    Stephanie Gras
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 89:388-95. 2011
    ..Here we review recent advances in the field, focusing on structural data pertaining to alloreactivity, and discuss the implications for T-cell-mediated transplant rejection...
  93. ncbi Noninvasive detection of graft rejection by in vivo (19) F MRI in the early stage
    U Flogel
    Cardiovascular Physiology, Heinrich Heine University Dusseldorf, Germany
    Am J Transplant 11:235-44. 2011
    ..Thus, PFCs can serve as positive contrast agent for the early detection of transplant rejection by (19) F MRI with high spatial resolution and an excellent degree of specificity due to lack of any (19) F background...
  94. ncbi Optimization of initial tacrolimus dose using pharmacogenetic testing
    E Thervet
    Department of Renal Transplantation, Assistance Publique Hopitaux de Paris, Necker Enfants Malades Hospital, Paris, France
    Clin Pharmacol Ther 87:721-6. 2010
    ..Pharmacogenetic adaptation of the daily dose of tacrolimus is associated with improved achievement of the target C(0). Whether this improvement will affect clinical outcomes requires further evaluation...
  95. pmc Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs
    Shipra Gupta
    Harvard Medical School, Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Invest 122:2395-404. 2012
    ..The frequency and number of TIM-3+ Tregs peaked at the time of graft rejection and declined thereafter...
  96. ncbi Face transplantation: outcomes, concerns, controversies, and future directions
    Maria Siemionow
    Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Craniofac Surg 23:254-9. 2012
    ..Since 2005, 17 facial allotransplantations have been performed worldwide. The brief summary of current cases with ongoing concerns is presented in this article...
  97. ncbi Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection
    Jacopo Mariotti
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:89-105. 2008
    ..In a B6-into-BALB/c graft rejection model, donor Th2/Tc2...
  98. ncbi Cardiovascular mortality among heart transplant recipients with asymptomatic antibody-mediated or stable mixed cellular and antibody-mediated rejection
    Abdallah G Kfoury
    Intermountain Medical Center and Intermountain Healthcare, Salt Lake City, UT, USA
    J Heart Lung Transplant 28:781-4. 2009
    ..In this study, we examined whether a differential impact on cardiovascular mortality (CVM) existed when comparing asymptomatic AMR, to stable MR or CR...
  99. pmc A molecular classifier for predicting future graft loss in late kidney transplant biopsies
    Gunilla Einecke
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
    J Clin Invest 120:1862-72. 2010
    ..In an independent validation set, the molecular risk score was the only predictor of graft loss. Thus, the molecular risk score reflects active injury and is superior to either scarring or function in predicting graft failure...
  100. pmc Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs
    Alberto Sanchez-Fueyo
    Liver Transplant Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
    Gastroenterology 140:51-64. 2011
    ..We review recently developed therapeutic strategies to promote tolerance to transplanted livers and other organs and diagnostic tools that might be used to identify patients most likely to accept or reject allografts...
  101. ncbi Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applications
    P Szodoray
    Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
    Scand J Rheumatol 39:1-11. 2010
    ..In this review, we summarize certain aspects of the molecular background of autologous stem cell transplantation and also depict the response to therapy in various autoimmune and rheumatic diseases...

Research Grants76

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  4. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ....
  5. Sphingosine 1-phosphate receptors in vascular homeostasis and pathology
    TIMOTHY TUN HLA; Fiscal Year: 2012
    ..These studies are expected to derive critical insights into the workings of S1P receptors, which are important drug targets to control the vascular and immune systems. ..
  6. Human Heme Oxygenase-1 Gene Regulation in Renal Injury
    Anupam Agarwal; Fiscal Year: 2012
    ..The results of these studies will also be applicable to other disease settings such as atherosclerosis, sepsis and transplant rejection wherein heme oxygenase-1 plays an important protective role. ..
  7. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..angiogenesis include chemical burns, chronic contact lens hypoxia, Stevens-Johnson syndrome, pterygia, graft rejection and infectious keratitis (2-4)...
  8. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis A Ortiz; Fiscal Year: 2012
    ..9 years) following transplantation than patients with IPF (5.34 and 2.4 years for survival and graft rejection respectively)...
  9. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..transduction with i) ex vivo transduction with Adv- hHGF-hIL-1Ra prevent primary islet nonfunction and early graft rejection after transplantation, ii)? i) Adv- hHGF-hIL-1Ra will improve islet function after intraportal ..
  10. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..Overall, our project will provide fundamental insights into the Orai1 proteins that are currently being targeted for treatment of autoimmune disorders and chronic inflammatory conditions. ..
  11. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..successful nonmyeloablative transplant to treat sickle cell anemia has been limited due to immune-mediated graft rejection. Our research has demonstrated that rapamycin can promote regulatory T cell (Treg) differentiation of naive T ..
  12. Depot calcineurin inhibitors to prevent graft rejection
    Thomas J Smith; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The long term goal of this research is to reduce toxicity and graft rejection due to dosing problems with the calcineurin inhibitors by developing a sustained release subcutaneous injectable ..
  13. Effects of lymphangiogenesis stimulation on lung allograft rejection
    Souheil El-Chemaly; Fiscal Year: 2013
    ..the hypothesis that inducing lymphangiogenesis after established rejection will lead to decreased signs of graft rejection and improved lung function...
  14. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..virus can reactivate as disseminated life-threatening infections, HCMV causes an increased incidence of graft rejection and EBV is associated with post-transplant lymphoproliferative disease...
  15. Modeling oxidative stress and DNA damage using GI organotypic culture systems
    John P Lynch; Fiscal Year: 2013
    ..It will also foster the development of novel therapeutic and preventive strategies that will improve patient care for these important clinical conditions. ..
  16. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..Preventing airway ischemia through knowledge gained about complement activity and regulation in rejection may promote useful and potentially life-saving therapies for lung transplant recipients. ..
  17. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    ..e. hepatitis C virus), but also in other T cell-mediated pathological conditions such as autoimmunity, graft rejection or cancer. Public Health Relevance: Hepatitis B virus (HBV) cause acute and chronic liver diseases...
  18. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2013
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. ..
  19. The Molecular Basis of Allorecognition in Social Amoeba
    Gad Shaulsky; Fiscal Year: 2013
    ..The MHC facilitates identification of parasites in infection processes, and graft rejection in transplantation medicine There is evidence for the involvement of other proteins in graft rejection but ..
  20. A search for genes that regulate allogeneic stem cell competition
    Irving L Weissman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Graft rejection in immune competent vertebrates can utilize both T and NK cell responses to hematopoietic cell transplants [HCT] and tissue grafts...
  21. Structure and function analysis of C1/C1q and MBL using a novel peptide inhibitor
    NEEL KUMAR KRISHNA; Fiscal Year: 2012
    ....
  22. GRAFT REJECTION AND DIRECT VERSUS INDIRECT RECOGNITION
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..In addition, the delineated mechanisms could have broad reaching implications for understanding adaptive immunity, including anti-pathogen immunity and autoimmunity. ..
  23. Sphingosine 1 phosphate receptors 1 and 3 as novel targets in transplantation
    Amandeep Bajwa; Fiscal Year: 2013
    ....
  24. Acute Humoral Rejection of Renal Allografts
    Robert L Fairchild; Fiscal Year: 2013
    ..specific antibody in CCR5-deficient recipients were almost 20-fold higher than in wild-type recipients and graft rejection was characteristic of acute humoral rejection observed in clinical transplants...
  25. The Role of Galectins in Corneal Hem- and Lymphangiogenesis
    Noorjahan Panjwani; Fiscal Year: 2013
    ..It is associated with a wide range of ocular disorders and is the major cause of corneal graft rejection. Indeed, the frequency of rejection reaches as high as 90% for corneal grafts placed in high-risk ..
  26. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
  27. Role of macrophages in pancreatic islet graft rejection
    Midhat H Abdulreda; Fiscal Year: 2013
    ..These findings will have implications in transplantation therapies in general, as well as in cancer and autoimmune conditions. ..
  28. TH17 Autoimmunity to Type V Collagen in Heart and Lung Transplant
    David S Wilkes; Fiscal Year: 2013
    ..abstract_text> ..
  29. Manipulation of beta-catenin signaling in adult oral cells for tooth regeneration
    Sarah E Millar; Fiscal Year: 2010
    ..cells to avoid practical and ethical issues surrounding the use of human embryonic tissues, and problems of graft rejection. While adult mesenchymal stem cells can participate in tooth bud formation, a suitable source of adult ..
  30. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2013
    ..BMT is difficult to achieve in chronically transfused patients, who have graft rejection at a much higher frequency than with BMT in other settings...
  31. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..3. Study the relationship between SDUV measurements of viscoelastic material properties with clinical measures for assessment of kidney transplant rejection. ..
  32. Structure and Function of Endothelial Fenestrae
    RADU VIRGIL STAN; Fiscal Year: 2010
    ..The techniques employed are cell isolation, fractionation, biochemical assays, cell free-assays, genetically modified animal models, cell culture, transfections, light and electron microscopy. ..
  33. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    ..Also, transplantation of allogeneic hepatocytes requires immunosuppression to prevent graft rejection. Three recent developments in our laboratory offer potential solutions to these problems...
  34. Delta-like ligand 4+ dendritic cells and induction of alloimmunity
    Yi Zhang; Fiscal Year: 2013
    ....
  35. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    ....
  36. B7-based, CD28 or CTLA-4-specific agonists and antagonists for tolerance inductio
    Roland K Strong; Fiscal Year: 2013
    ..limitations of allogeneic HCT in patients with nonmalignant disorders have been host-versus-graft reactions (graft rejection) and immune reactions of donor lymphocytes against host antigens, also called graft-versus-host disease (GVHD)..
  37. KSHV Lytic DNA Replication and its Control Mechanism
    Subhash C Verma; Fiscal Year: 2013
    ..individuals including HIV infected individuals and patients receiving immune suppressive therapies to prevent graft rejection. KSHV induced tumors are one of the major causes of morbidity and mortality of HIV/AIDS patients...
  38. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2013
    ..Understanding the factors that reverse autoimmunity in the IL-2Rb- deficient model may also provide new information concerning the etiology and potential therapy that may be generally common to several human autoimmune diseases. ..
  39. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2013
    ..abstract_text> ..
  40. A High-throughput Screen of Lytic Granule Exocytosis
    Adam Zweifach; Fiscal Year: 2012
    ..If it can, we will use it to screen a large scale compound library for inhibitory compounds. ..
  41. Home ECG Monitoring to Detect Allograft Rejection Following Heart Transplantation
    Barbara J Drew; Fiscal Year: 2013
    ..The public health benefit of detecting a simple ECG marker of heart transplant rejection is that it might yield earlier detection, allow more timely initiation of medical therapy and reduce mortality from acute rejection. ..
  42. ATF3 and iNOS in Islet Distruction and Graft Rejection
    Tsonwin Hai; Fiscal Year: 2010
    ..Aim 2: To test whether islets deficient in ATF3 and/or iNOS have reduced graft rejection. Three experimental islet transplant models will be used to determine whether the lack of ATF3 and/or iNOS ..
  43. IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB
    Jeffrey A Bluestone; Fiscal Year: 2013
    ....
  44. TIM Family of Genes: Role in T Cell Immunity and Tolerance
    Vijay K Kuchroo; Fiscal Year: 2012
    ..abstract_text> ..
  45. Genome Transplant Dynamics: non-invasive sequencing-based diagnosis of rejection
    HANNAH AUGUSTA contact VALANTINE; Fiscal Year: 2010
    ..Previous attempts to develop a non-invasive marker of graft rejection have focused on recipient-specific immune responses, and thus have inherent limitations in sensitivity and ..
  46. Regulatory T cells in the influenza response of the aged
    Phyllis Jean Linton; Fiscal Year: 2009
    ....
  47. The DNA Damage Response as a therapeutic target in BK virus nephropathy
    THOMAS DAVID FRIEDRICH; Fiscal Year: 2013
    ..in cases where BKV is refractory to reduced immunosuppression or when PVAN occurs in combination with acute graft rejection. The primary goal of this application is to identify therapeutic compounds that limit replication of BKV by ..
  48. Maturation of Human Lymphocytes for Transplantation
    Gerald J Spangrude; Fiscal Year: 2010
    ..the only approach to this problem currently in routine clinical use is immunosuppressive therapy to limit graft rejection and graftversus- host disease (GVHD)...
  49. T cell regulation by IDO-competent plasmacytoid dendritic cells
    ANDREW LEE MELLOR; Fiscal Year: 2010
    ..This observation provides a rationale for treating mice with donor allograft and self-antigens to induce tolerance that will protect skin grafts and pancreatic islet cells from T cell mediated destruction. 1 ..
  50. Therapeutic-Expression of a Platelet-Specific Integrin
    DAVID ALLEN WILCOX; Fiscal Year: 2010
    ..find suitable marrow donors and recipients may also suffer deleterious effects from graft-vs-host disease and graft rejection. We have recently shown a potentially feasible solution for this problem by transferring a therapeutic gene ..
  51. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..
  52. Mechanisms and Regulation of Inducible Nitric Oxide Synthase
    JOSEPH EDWARD SABAT; Fiscal Year: 2010
    ..Knowledge gained from this research project will aid in the design of isoform specific inhibitors aimed at ameliorating the oxidative stress incurred in chronic inflammatory conditions. ..
  53. Novel Urinary Proteomic Biomarkers for Acute Renal Transplant Rejection
    Minnie M Sarwal; Fiscal Year: 2010
    ..In this study, we propose to utilize two most powerful proteomic techniques to identify non-invasive proteomic biomarkers for acute rejection. ..
  54. Novel Biologic Therapies for BMT: Mechanistic Evaluation in Rhesus Macaques
    Leslie S Kean; Fiscal Year: 2013
    ..Three major complications have plagued the implementation of AD-BMT. They are: (1) The increased risk of graft rejection. (2) The high rate of acute graft-versus-host-disease (aGvHD) that occurs in the setting of MHC-mismatched ..
  55. Chromatin states encoding fate commitment and plasticity of tolerant CD8 T cells
    Philip D Greenberg; Fiscal Year: 2013
    ....
  56. The Role of Glucocorticoids in Cell Fate Determination
    Brian J Feldman; Fiscal Year: 2010
    ..In addition, it will shed light on the mechanisms of GC action which has important implications for understanding the development of diseases such as diabetes. ..
  57. MOCSLID-DCC
    Robert M Elashoff; Fiscal Year: 2012
    ..abstract_text> ..
  58. Bioengineered siRNA/Nanoparticles to Prevent Human Transplant Rejection
    George Tellides; Fiscal Year: 2013
    ..directly recognizing non-self-major histocompatibility complex (MHC) molecules and, upon activation, causing graft rejection. The high frequency of alloreactive memory cells is thought to account for the failure in humans of many ..
  59. REGULATION OF NEONATAL IMMUNITY
    Habib Zaghouani; Fiscal Year: 2010
    ..tolerance is feasible and the approach has proven useful for understanding allogeneic and allergic reactions, graft rejection and transplantation tolerance...
  60. ANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAY
    WAYNE WILLIAM HANCOCK; Fiscal Year: 2011
    ..Our studies should have major consequences for the development of new strategies for therapy in patients with multiple types of autoimmunity and transplant rejection. ..
  61. Adenosine 2A Receptor Signaling in Lung Transplant Injury and Rejection
    Christine L Lau; Fiscal Year: 2013
    ..Given the anti- inflammatory and immunomodulating effects of A2ARs, strategies utilizing A2AR agonists may be uniquely suited to prevent both the alloimmune-independent and alloimmune-dependent factors involved in BO. ..
  62. Evaluation of stem cell-derived retinal pigment epithelial cells for retinal dise
    MARTHA D NEURINGER; Fiscal Year: 2013
    ..generate novel data on the immune response to such therapeutic intervention and the best approach to avoid graft rejection. The proposal will address these issues in an animal model with an eye and immune system that most closely ..
  63. Sustained release calcineurin inhibitors for the prevention of graft rejection
    Thomas Smith; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): The long term goal of this research is to reduce toxicity and graft rejection due to dosing problems with the calcineurin inhibitors by developing sustained release subcutaneous ..
  64. ApoFasL: a Novel Immunotherapeutic for T1D
    Rolf Huseby; Fiscal Year: 2007
    ..the display of FasL on pancreatic islets (ApoFasL therapy) using ProtEx(tm) resulted in the prevention of graft rejection and treatment of chemically-induced diabetes in an allogeneic transplant model...
  65. 6th Biennial International Eosinophil Symposium - "Eosinophils 2009"
    Steven Ackerman; Fiscal Year: 2009
    ..damage, repair, remodeling and fibrosis, (8) eosinophils in parasite infections, allergic inflammation, graft rejection and cancer, and (9) new therapeutic targets for eosinophil-mediated diseases...
  66. Analysis of T cell epitope repertoire
    Yoram Louzoun; Fiscal Year: 2007
    ..This part of the research will be done in colaboration with an experimental group studying the B and T cell repertoire in autoimmunity. [unreadable] [unreadable] [unreadable]..
  67. Role of VEGF in Glomerular Endothelial Health & Diseases
    S Karumanchi; Fiscal Year: 2007
    ..abstract_text> ..
  68. Movement of Recipient T-Cells Away From an Allograft
    Mark Poznansky; Fiscal Year: 2003
    ..To date therapeutic control over both acute and chronic graft rejection has been achieved predominantly with immunosuppressive agents targeted against the function of activated ..
  69. Role of autoimmunity in transplant rejection
    Gilles Benichou; Fiscal Year: 2007
    ..in heart-transplanted individuals, the CD4 pathway of alloresponse contributes to acute and/or chronic heart graft rejection by triggering autoimmune responses to CM thereby causing cardiac tissue damages in a fashion similar to that ..
  70. Optimizing Nonmyeloablative Stem Cell Transplantation
    Marco Mielcarek; Fiscal Year: 2007
    ..Most nonablative conditioning regimens contain irradiation, which is thought to be required to prevent graft rejection. However, low doses of irradiation are associated with increased risks of late malignancies, and avoiding ..
  71. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ....
  72. Antigen Specific T Cell Tolerance by Anti CD3 Antibodie
    Claudio Anasetti; Fiscal Year: 2001
    ..project is to develop methods for induction of peripheral T cell tolerance that could improve prevention of graft rejection and graft-versus-host disease (GVHD) after human marrow transplantation...
  73. ENGRAFTING SENSITIZED HOSTS WITH NONABLATIVE REGIMENS
    Richard Nash; Fiscal Year: 2002
    ..with blood products become sensitized to donor minor histocompatibility antigens, increasing the risk of graft rejection. Patients with inherited red blood cell diseases require blood transfusions and have a higher probability of ..
  74. CORNEAL TRANSPLANTATION STUDIES
    Maureen Maguire; Fiscal Year: 1992
    ..Eyes with corneal stroma vascularization or a history of corneal graft rejection will be eligible for the CCTS...
  75. COLLABORATIVE CORNEAL TRANSPLANTATION STUDIES
    Gary Foulks; Fiscal Year: 1991
    ..Eyes with corneal stroma vascularization or a history of corneal graft rejection will be eligible for the CCTS...
  76. ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLY
    Joyce Solheim; Fiscal Year: 2009
    ..abstract_text> ..