Genomes and Genes
Summary: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Publications300 found, 100 shown here
- Improved graft survival after renal transplantation in the United States, 1988 to 1996S Hariharan
Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
N Engl J Med 342:605-12. 2000..The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known...
- Banff 07 classification of renal allograft pathology: updates and future directionsK Solez
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
Am J Transplant 8:753-60. 2008....
- Mast cells are essential intermediaries in regulatory T-cell toleranceLi Fan Lu
Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
Nature 442:997-1002. 2006..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
- Gene-expression profiling for rejection surveillance after cardiac transplantationMichael X Pham
Stanford University Medical Center, Stanford, California, USA
N Engl J Med 362:1890-900. 2010..However, this procedure is uncomfortable, and there are risks associated with it. Gene-expression profiling of peripheral-blood specimens has been shown to correlate with the results of an endomyocardial biopsy...
- Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejectionLorraine C Racusen
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Transplant 3:708-14. 2003..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
- A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathyXueli Yuan
Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 205:3133-44. 2008..These results have important implications for the development of novel therapies to target this intractable problem in clinical solid organ transplantation...
- Pediatric cardiac transplantation in children with high panel reactive antibodyJeffrey P Jacobs
The Congenital Heart Institute of Florida, All Children s Hospital, University of South Florida, St Petersburg, Florida, USA
Ann Thorac Surg 78:1703-9. 2004..We retrospectively reviewed our management strategy and outcome data for children undergoing heart transplantation with high PRA (> 10%)...
- Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejectionSusan Stewart
Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
J Heart Lung Transplant 26:1229-42. 2007..This consensus revision of the working formulation was approved by the ISHLT board of directors in April 2007...
- Low levels of human leukocyte antigen donor-specific antibodies detected by solid phase assay before transplantation are frequently clinically irrelevantVincent Aubert
Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Hum Immunol 70:580-3. 2009..The only AHR episode occurred in a recipient with pretransplantation DSA. More work should be performed to better delineate the precise clinical significance of detecting low titers of DSA before transplantation...
- Heterologous immunity provides a potent barrier to transplantation toleranceAndrew B Adams
Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Clin Invest 111:1887-95. 2003..These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function...
- A molecular classifier for predicting future graft loss in late kidney transplant biopsiesGunilla Einecke
Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
J Clin Invest 120:1862-72. 2010..In an independent validation set, the molecular risk score was the only predictor of graft loss. Thus, the molecular risk score reflects active injury and is superior to either scarring or function in predicting graft failure...
- Evaluation of a topical cyclosporine A prodrug on corneal graft rejection in ratsJ L Bourges
INSERM, U598, Paris, France
Mol Vis 12:1461-6. 2006..To assess the efficacy of a topical cyclosporine A (CsA), water-soluble prodrug, for promoting the survival of allogenic rat corneal grafts after penetrating keratoplasty (PKP)...
- Cardiovascular mortality among heart transplant recipients with asymptomatic antibody-mediated or stable mixed cellular and antibody-mediated rejectionAbdallah G Kfoury
Intermountain Medical Center and Intermountain Healthcare, Salt Lake City, UT, USA
J Heart Lung Transplant 28:781-4. 2009..In this study, we examined whether a differential impact on cardiovascular mortality (CVM) existed when comparing asymptomatic AMR, to stable MR or CR...
- Mechanisms involved in antibody- and complement-mediated allograft rejectionBarbara A Wasowska
Department of Pathology, The Johns Hopkins University School of Medicine, Ross Bldg 664B, Baltimore, MD 21205, USA
Immunol Res 47:25-44. 2010..transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of ..
- Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organsAlberto Sanchez-Fueyo
Liver Transplant Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
Gastroenterology 140:51-64. 2011..We review recently developed therapeutic strategies to promote tolerance to transplanted livers and other organs and diagnostic tools that might be used to identify patients most likely to accept or reject allografts...
- Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applicationsP Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
Scand J Rheumatol 39:1-11. 2010..In this review, we summarize certain aspects of the molecular background of autologous stem cell transplantation and also depict the response to therapy in various autoimmune and rheumatic diseases...
- Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')K Solez
University of Alberta, Edmonton, Alberta, Canada
Am J Transplant 7:518-26. 2007..Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference...
- Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejectionJacopo Mariotti
Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 180:89-105. 2008..In a B6-into-BALB/c graft rejection model, donor Th2/Tc2...
- Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cellsRoss S Francis
Transplant Research Immunology Group, Nuffield Department of Surgery, University of Oxford John Radcliffe Hospital, Oxford, UK
Eur J Immunol 41:726-38. 2011....
- Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injuryLeo E Otterbein
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
Nat Med 9:183-90. 2003..These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent...
- Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomesGrace W Wu
Division of Cardiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 6988, USA
J Heart Lung Transplant 28:417-22. 2009..The significance of AMR findings in biopsy specimens of asymptomatic heart transplant patients (normal cardiac function and no symptoms of heart failure) is unclear...
- Endothelial injury, alarmins, and allograft rejectionDeepak A Rao
Department of Immunobiology, Section of Human and Translational Immunology, Yale University School of Medicine, New Haven, CT 06520 8089, USA
Crit Rev Immunol 28:229-48. 2008....
- Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent eraHerwig Ulf Meier-Kriesche
University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
Am J Transplant 4:378-83. 2004..However, the etiology of this concerning trend for worse death censored graft survival in recent years will warrant further investigation...
- Transplant glomerulopathy: risk and prognosis related to anti-human leukocyte antigen class II antibody levelsNaim Issa
Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Transplantation 86:681-5. 2008..The goal of this study was to determine the relationships among antibody characteristics (level and specificity), risk for TG, and graft survival...
- Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cellsYi-Ping Jin
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Hum Immunol 65:291-302. 2004..These results suggest that exposure of the graft endothelium to low concentrations of anti-HLA Ab may promote cell survival by transducing signals resulting in upregulation of cell survival genes...
- Role of immunoproteasomes in cross-presentationMichael J Palmowski
Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
J Immunol 177:983-90. 2006....
- The changing role of natural killer cells in solid organ rejection and toleranceWilliam H Kitchens
Division of Transplantation, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Transplantation 81:811-7. 2006..These new findings suggest that the role of NK cells in solid organ rejection and tolerance needs to be reexamined...
- Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft lossF Moreso
Nephrology Department, Hospital Universitari de Bellvitge, IDIBELL (Institut d'Investigacio de Bellvitge, C/Feixa Llarga s/n, L'Hospitalet 08907 Barcelona, Spain
Am J Transplant 6:747-52. 2006..27, 95% CI: 1.38-3.75; p = 0.01) were independent predictors of graft survival. In protocol biopsies, the detrimental effect of interstitial fibrosis/tubular atrophy on long-term graft survival is modulated by SCR...
- Predicting subsequent decline in kidney allograft function from early surveillance biopsiesFernando G Cosio
Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnnesota, USA
Am J Transplant 5:2464-72. 2005..In conclusion, inflammation and glomerulopathy 1 year post-transplant predict loss of graft function and graft failure independently of function and other variables...
- Pediatric heart transplantation in human leukocyte antigen sensitized patients: evolving management and assessment of intermediate-term outcomes in a high-risk populationStacey M Pollock-Barziv
Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children University of Toronto, Toronto, Ontario, Canada
Circulation 116:I172-8. 2007..We report our experience with human leukocyte antigens-sensitized pediatric HTx recipients...
- Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant StudyDonald T H Tan
Singapore National Eye Centre, Singapore
Ophthalmology 115:975-982.e1. 2008..The indications, complications, long-term survival rates, and risk factors for graft failure of penetrating keratoplasty (PK) performed in Asian eyes are reported...
- Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft functionE C Aquino-Dias
Post Graduate Medical Sciences Nephrology Program, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Kidney Int 73:877-84. 2008..Our study shows that quantification of selected genes in peripheral blood leukocytes and urinary cells from renal transplant patients with DGF may provide a useful and accurate non-invasive diagnosis of AR...
- Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat modelPaolo Sbano
Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Siena, Italy
Arch Dermatol Res 300:115-24. 2008..Results of our study in a rat tissue transplantation model demonstrated a possible immunogenic role for donor (allogeneic) MSC, confirming the need of adequate preclinical experimentation before clinical use...
- In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantationRutger Jan Swijnenburg
Department of Cardiothoracic Surgery, Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA
Stem Cells Dev 17:1023-9. 2008..These data show that mESCs do not retain immune-privileged properties in vivo and are subject to immunological rejection as assessed by novel molecular imaging approaches...
- TIM-1 and TIM-3 proteins in immune regulationEe Wern Su
Department of Immunology, University of Pittsburgh, 200 Lothrop Street, BST E 1056, Pittsburgh, PA 15261, USA
Cytokine 44:9-13. 2008..We therefore propose that the definition of TIM be adjusted to "transmembrane immunoglobulin and mucin"...
- Anti-HLA donor-specific antibodies detected in positive B-cell crossmatches by Luminex predict late graft lossH S Eng
Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia
Am J Transplant 8:2335-42. 2008..Thus, using BXM to preclude kidney transplantation may potentially disadvantage >60% of patients in whom BXM is not indicative of the presence of DSA...
- Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejectionBanu Sis
Department of Laboratory Medicine and Pathology, University of Alberta, Alberta, Canada
Curr Opin Organ Transplant 15:42-8. 2010..This article reviews recent molecular studies in kidney allograft tissues that decipher molecular burden and mechanisms of ABMR, leading to discovery of a new phenotype: 'C4d-negative ABMR'...
- Plasmapheresis and cyclophosphamide in the treatment of humoral rejection after heart transplantationO Grauhan
Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
J Heart Lung Transplant 20:316-21. 2001..Clinical reports on humoral rejection after heart transplantation showed that these episodes were often more severe than those mediated through T lymphocytes and that the patient's prognosis was significantly worsened...
- ABO-incompatible heart transplantation in infantsL J West
Department of Paediatrics, Hospital for Sick Children and University of Toronto, ON, Canada
N Engl J Med 344:793-800. 2001..This contraindication may not apply to newborn infants, who do not yet produce antibodies to T-cell-independent antigens, including the major blood-group antigens...
- Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboonsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
Am J Pathol 172:1471-81. 2008....
- Airway epithelium is the primary target of allograft rejection in murine obliterative airway diseaseFelix G Fernandez
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
Am J Transplant 4:319-25. 2004..This indicates that the airway epithelium plays a crucial role in OAD development...
- Bortezomib provides effective therapy for antibody- and cell-mediated acute rejectionMatthew J Everly
Department of Surgery, Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
Transplantation 86:1754-61. 2008..We report the first clinical experience with plasma cell-targeted therapy (bortezomib) as an antirejection strategy...
- Pathways of allorecognition: implications for transplantation toleranceDavid S Game
Department of Immunology, Imperial College School of Medicine, London, UK
Transpl Immunol 10:101-8. 2002..It is hoped that the careful study of these mechanisms will reveal ways of ensuring allorecognition without activation and thus donor-specific tolerance...
- Abrogation of anti-HLA antibodies via proteasome inhibitionHargovind L Trivedi
Department of Nephrology and Transplantation Medicine, Institute of Kidney Diseases and Research Centre Institute of Transplantation Sciences, Ahmedabad, Gujarat, India
Transplantation 87:1555-61. 2009..We report the first clinical experience with a plasma cell depleting therapy, bortezomib, to abrogate anti-HLA antibodies in transplantation (outside of rejection) in an attempt to improve long-term allograft survival...
- Timing of sirolimus conversion influences recovery of renal function in liver transplant recipientsChristin C Rogers
Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA, USA
Clin Transplant 23:887-96. 2009..The only improvement in the LC group was from conversion to the three-month time point. We conclude that EC to SRL results in a profound improvement in eGFR that begins at three months and is sustained beyond one yr...
- Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantationJ M Gloor
Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Am J Transplant 10:582-9. 2010..With current protocols, very high baseline DSA patients have high rates of AMR and poor long-term allograft survival highlighting the need for improved therapy for these candidates...
- Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant recipientsTajinder P Singh
Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Heart Lung Transplant 29:517-22. 2010..In this study, we report early clinical outcomes in a cohort of pediatric heart transplant recipients managed using a steroid-avoidance protocol...
- Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantationL Fan
Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
Am J Transplant 11:911-22. 2011..In addition, these data indicate that neutralizing IL-17A or augmenting IL-10 could be therapeutic interventions to prevent OB...
- Comparison of multiplex meta analysis techniques for understanding the acute rejection of solid organ transplantsAlexander A Morgan
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
BMC Bioinformatics 11:S6. 2010....
- Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: an analysis of the United Network for Organ Sharing databaseJoseph W Rossano
Department of Pediatrics, Lillie Frank Abercrombie Section of Pediatric Cardiology, Baylor College of Medicine, Texas Children s Hospital, Houston, Tex 77030, USA
J Thorac Cardiovasc Surg 140:694-9, 699.e1-2. 2010..This study sought to determine the association of elevated anti-human leukocyte antibodies with long-term survival in pediatric heart transplant patients...
- Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantationDirk R J Kuypers
Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
Clin J Am Soc Nephrol 5:341-58. 2010..Although this consensus report does not evaluate the final role of MPA TDM in transplantation, it seeks to examine the current scientific evidence for concentration-controlled dosing of MPA...
- Shotgun proteomics identifies proteins specific for acute renal transplant rejectionTara K Sigdel
Department of Pediatrics, Stanford University School of Medicine, CA 94304, USA
Proteomics Clin Appl 4:32-47. 2010..Acute rejection (AR) remains the primary risk factor for renal transplant outcome; development of non-invasive diagnostic biomarkers for AR is an unmet need...
- Controversies in defining cardiac antibody-mediated rejection: need for updated criteriaAbdallah G Kfoury
Intermountain Medical Center and Intermountain Healthcare, Cardiac Transplant Program, Salt Lake City, Utah 84107, USA
J Heart Lung Transplant 29:389-94. 2010..This perspective examines some of the contentious and unresolved issues in cardiac AMR as the transplant community makes concrete steps towards updating its defining criteria...
- A systematic review on steroid withdrawal between 3 and 6 months after kidney transplantationJulio Pascual
Servicio de Nefrologia, Hospital del Mar, Institut Municipal d Asistencia Sanitaria, Universitat Autonoma de Barcelona, Barcelona, Spain
Transplantation 90:343-9. 2010..Steroid withdrawal (SW) after the first posttransplant months in patients receiving a kidney transplant has been recently discouraged in clinical guidelines...
- Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urineB Li
Department of Medicine, Weill Medical College of Cornell University, New York, USA
N Engl J Med 344:947-54. 2001..CONCLUSIONS: Measurement of mRNA encoding cytotoxic proteins in urinary cells offers a noninvasive means of diagnosing acute rejection of renal allografts...
- Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beadsPatrizia Amico
Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
Transplantation 87:1681-8. 2009..The aims of this study were to investigate to which extent HLA-DSA detected by SAFB represent a risk for antibody-mediated rejection (AMR) and diminished allograft survival, and to define HLA-DSA characteristics predictive for AMR...
- A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)A Durrbach
Bicetre Hospital, Kremlin Bicetre, IFRNT, Universite Paris Sud, France
Am J Transplant 10:547-57. 2010....
- Antibody testing for cardiac antibody-mediated rejection: which panel correlates best with cardiovascular death?Monica P Revelo
George E Wahlen Veterans Affairs Medical Center, Utah Transplantation Affiliated Hospitals, Salt Lake City, Utah, USA
J Heart Lung Transplant 30:144-50. 2011....
- Adenosine A(2A) agonist administration improves islet transplant outcome: Evidence for the role of innate immunity in islet graft rejectionPreeti Chhabra
Department of Surgery, University of Virginia, Charlottesville, 22908 0709, USA
Cell Transplant 19:597-612. 2010....
- Large-diameter penetrating keratoplasty: indications and outcomesHeather M Skeens
Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA
Cornea 29:296-301. 2010..To report the indications and outcomes of patients who underwent large-diameter penetrating keratoplasty (LDPK) for the management of peripheral corneal disease...
- Allogeneic renal graft rejection in a rat model: in vivo MR imaging of the homing trait of macrophagesEun Young Chae
Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Songpagu, Seoul, South Korea
Radiology 256:847-54. 2010To evaluate the feasibility of MR imaging to depict the in vivo recruitment of superparamagnetic iron oxide (SPIO)-labeled macrophages and to aid diagnosis of graft rejection in kidney transplantation.
- Corneal graft surgery combined with subconjunctival bevacizumab (avastin)Richard J Symes
Department of Ophthalmology, Frimley Park Hospital, Camberley, Surrey, United Kingdom
Cornea 29:691-3. 2010To describe the use of subconjunctival bevacizumab (Avastin) as an adjunctive treatment in a vascularized cornea at the time of lamellar keratoplasty to reduce the risk of graft rejection.
- Opinions on risk factors and management of corneal graft rejection in the United kingdomPeter Y P Koay
Department of Ophthalmology, St John s Hospital, Livingston, United Kingdom
Cornea 24:292-6. 2005To determine the opinions regarding risk factors and practice preferences for corneal graft rejection by members of the Bowman Club (UK) and to compare them with those of members of the Castroviejo Society (USA).
- ABO incompatible renal transplantation: a paradigm ready for broad implementationRobert A Montgomery
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Transplantation 87:1246-55. 2009....
- Cytotoxic T lymphocytes: all roads lead to deathMichele Barry
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
Nat Rev Immunol 2:401-9. 2002..lytic machinery can be directed against self-tissues in autoimmune disorders, transplanted cells during graft rejection and host tissues to cause graft-versus-host disease, which is one of the most serious diseases related to CTL ..
- The relevance of minor histocompatibility antigens in solid organ transplantationMiranda Dierselhuis
Department of Immunohematology and Bloodtranfusion, Leiden University Medical Center, Leiden, The Netherlands
Curr Opin Organ Transplant 14:419-25. 2009..Here we summarize, to the best of our knowledge, human studies on the relevance of minor histocompatibility antigens in solid organ transplantation with a main focus on renal allografting...
- In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cellsSatish N Nadig
Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
Nat Med 16:809-13. 2010..We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy...
- Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 monthsAndreas Scherer
Novartis Pharma AG, Basel, Switzerland
Nephrol Dial Transplant 24:2567-75. 2009....
- Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipientsP M Soccal
Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva
Clin Infect Dis 51:163-70. 2010....
- Prevention of hyperacute rejection in a model of orthotopic liver xenotransplantation from pig to baboon using polytransgenic pig livers (CD55, CD59, and H-transferase)P Ramirez
Liver Transplant Unit, Department of Surgery, Virgen Arrixaca University Hospital, Murcia, Spain
Transplant Proc 37:4103-6. 2005....
- Mechanisms of transplant tolerance induction using costimulatory blockadeThomas Wekerle
The Division of Transplantation, Department of Surgery, Vienna General Hospital, University of Vienna, Waehringer Guertel 18, A 1090 Vienna, Austria
Curr Opin Immunol 14:592-600. 2002....
- Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism?Jacek R Wilczynski
Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Lodz, Poland
Hum Immunol 67:492-511. 2006..Analysis of immune reactions shows that graft rejection shares many similar mechanisms with RA and PE...
- Heart transplantation. A retrospective analysis of the long-term resultsSuk Jung Choo
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138- 736, Korea
Yonsei Med J 45:1173-80. 2004..The complications encountered after transplantation were mostly immunosuppressive drug related, suggesting further potentials for improvement in long-term survival...
- Graft failure IV. Immunologic mechanisms of corneal transplant rejectionEva Marie Chong
Cornea Service, Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Int Ophthalmol 28:209-22. 2008..Immunologic graft rejection is one of the main causes of short and long-term graft failure...
- Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate modelGil Hecht
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 106:8659-64. 2009..Its long-term proliferative capacity, its revascularization by host endothelium, and its reduced immunogenicity, strongly suggest that this approach could offer an attractive replacement therapy for diabetes...
- Increased expression of cytotoxic effector molecules: different interpretations for steroid-based and steroid-free immunosuppressionThomas Satterwhite
Department of Pediatrics, Stanford University School of Medicine, 269 Campus Drive, CCSR, Stanford, California 94305, USA
Pediatr Transplant 7:53-8. 2003....
- The immune response to corneal allograft requires a site-specific draining lymph nodeJarmila Plsková
Department of Ophthalmology, University of Aberdeen, Medical School Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
Transplantation 73:210-5. 2002..In this study we have investigated further the role of the DLN and spleen in corneal graft rejection in mice.
- Epidemiology and risk factors for corneal graft rejectionD Sellami
Department of Ophthalmology, CHU Habib Bourguiba, 3029 Sfax, Tunisia
Transplant Proc 39:2609-11. 2007The aim of this study was to evaluate the frequency and main risk factors for corneal graft rejection.
- Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejectionVanessa Oliveira
Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
Eur J Immunol 38:1677-88. 2008..This study shows that alloantigen stimulation in the presence of anti-CD4 in vitro provides a simple and effective strategy to generate alloreactive Treg...
- Five-year safety and efficacy of belatacept in renal transplantationFlavio Vincenti
Division of Nephrology, University of California, San Francisco, 505 Parnassus Avenue, Moffitt 884, San Francisco, CA 94143 0780, USA
J Am Soc Nephrol 21:1587-96. 2010..In conclusion, this study demonstrated high patient persistence with intravenous belatacept, stable renal function, predictable pharmacokinetics, and good safety with belatacept over 5 years...
- Endothelial cell chimerism after renal transplantation and vascular rejectionE L Lagaaij
Department of Pathology, Leiden University Medical Centre, The Netherlands
Lancet 357:33-7. 2001..The endothelium in the blood vessels is thought to be the major target for graft rejection. Endothelial cells of a transplanted organ are believed to remain of donor origin after transplantation...
- Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty studyMichael Kuchle
Department of Ophthalmology and University Eye Hospital, University Erlangen Nurnberg, Schwabachanlage 6, Germany
Graefes Arch Clin Exp Ophthalmol 240:580-4. 2002..To analyze the incidence of and possible risk factors for endothelial corneal allograft rejection in a well-defined population following penetrating normal-risk keratoplasty...
- Statin use is associated with improved function and survival of lung allograftsBruce A Johnson
Department of Medicine, University of Pittsburgh, 628 NW MUH, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 167:1271-8. 2003..01). The 6-year survival of recipients taking statins (91%) was much greater than that of control subjects (54%) (p < 0.01). These data suggest statin use may have substantial clinical benefits after pulmonary transplantation...
- IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivoM Hara
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 166:3789-96. 2001..CD4(+) T cells contained within the CD45RB(high) fraction remained capable of mediating graft rejection when transferred to donor alloantigen-grafted T cell-depleted mice...
- Aortic allograft vasculopathy is mediated by CD8(+) T cells in Cyclosporin A immunosuppressed miceEllen L Vessie
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
Transpl Immunol 15:35-44. 2005..The in vitro data suggest that the indirect pathway remains intact in this population of CyA resistant CD8(+) T cells...
- Transition to the adult nephrologist does not induce acute renal transplant rejectionMaria E N van den Heuvel
Department of Pediatric Nephrology, Emma Children s Hospital AMC, PO Box 22700, 1100 DE Amsterdam, The Netherlands
Nephrol Dial Transplant 25:1662-7. 2010..In spite of the overall increased renal graft survival, long-term allograft survival has remained least successful in adolescent recipients. A major change in their care is the transition from the paediatric to the adult nephrology unit...
- Serial chimerism analyses indicate that mixed haemopoietic chimerism influences the probability of graft rejection and disease recurrence following allogeneic stem cell transplantation (SCT) for severe aplastic anaemia (SAA): indication for routine assessMark Lawler
Durkan Research Laboratories, Department of Haematology, Institute of Molecular Medicine, St James s Hospital and Trinity College, Dublin, Ireland
Br J Haematol 144:933-45. 2009..C) stable mixed chimeras (n = 18), (D) progressive mixed chimeras (n = 14) (E) recipient chimeras with early graft rejection (n = 5)...
- Conversion from a calcineurin inhibitor to everolimus therapy in maintenance liver transplant recipients: a prospective, randomized, multicenter trialPaolo De Simone
Liver Transplantation Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
Liver Transpl 15:1262-9. 2009..Trials targeting earlier conversion post-transplantation are required to confirm the efficacy and safety of everolimus for improving renal function after liver transplantation...
- Epidemiology of cytomegalovirus infection after pancreas transplantationAjay K Parsaik
Division of Endocrinology, Diabetes, Nutrition, and Metabolism, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
Transplantation 92:1044-50. 2011....
- Late steroid withdrawal after ABO blood group-incompatible living donor kidney transplantation: high rate of mild cellular rejectionTobias Oettl
Clinic for Transplantation Immunology and Nephrology, University Hospital, Basel, Switzerland
Transplantation 89:702-6. 2010..Little is known about the safety of steroid withdrawal after ABO blood group-incompatible living donor kidney transplantation...
- Graft survival and cytokine production profile after limbal transplantation in the experimental mouse modelAnna Lencova
Institute of Molecular Genetics, Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic
Transpl Immunol 24:189-94. 2011..The limbal graft rejection was prevented with anti-CD4, but not anti-CD8 monoclonal antibody therapy...
- Genetic interactions between the donor and the recipient for susceptibility to acute rejection in kidney transplantation: polymorphisms of CCR5Ran hui Cha
Department of Internal Medicine, Seoul National University College of Medicine, Korea
Nephrol Dial Transplant 24:2919-25. 2009....
- Does the KIR2DS5 gene protect from some human diseases?Izabela Nowak
Department of Clinical Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
PLoS ONE 5:e12381. 2010..KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation...
- Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejectionDirk Jan Slebos
Department of Pulmonary Diseases and Lung Transplantation, University Hospital Groningen, Groningen, The Netherlands
J Heart Lung Transplant 23:532-40. 2004The detection of graft rejection by bronchoalveolar lavage remains controversial.
- Alemtuzumab (CAMPATH-1H) for the treatment of acute rejection in kidney transplant recipients: long-term follow-upMenna R Clatworthy
Division of Renal Medicine, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Transplantation 87:1092-5. 2009..This article reports the long-term follow-up data from the first series of patients treated with alemtuzumab for biopsy-proven acute rejection (BPAR)...
- When killers become helpersJacob Hanna
The Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
Trends Immunol 28:201-6. 2007..Such functions include promoting placental tissue development, antigen presentation and stimulation of T cells, priming of macrophages and dendritic cells, reducing transplant tissue rejection and several others...
- Feasibility study of lamellar keratoplasty in a murine modelTing Huang
Key Laboratory of Ophthalmology of the Ministry of Education and Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, Guangdong, China
Ocul Immunol Inflamm 17:257-64. 2009..There is debate about relative merits of each approach, but experimental comparisons have never been performed in animal models. Therefore, the authors developed a murine LK model...
- Antibody-mediated organ-allograft rejectionRobert B Colvin
Department of Pathology, Warren 225, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02140, USA
Nat Rev Immunol 5:807-17. 2005..Antibody and complement also induce gene expression by endothelial cells, which is thought to remodel arteries and basement membranes, leading to fixed and irreversible anatomical lesions that permanently compromise graft function...
- Review of major clinical trials with mycophenolate mofetil in renal transplantationGaetano Ciancio
Department of Surgery, Division of Transplantation, Lillian Jean Kaplan Renal Transplant Center, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
Transplantation 80:S191-200. 2005....
- Mycophenolate mofetil in combination with reduction of calcineurin inhibitors for chronic renal dysfunction after liver transplantationGeorges Philippe Pageaux
Liver Transplant Unit, Centre Hospitalier Universitaire CHU Saint Eloi, Montpellier, France
Liver Transpl 12:1755-60. 2006....
- Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of miceThai M Cao
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 100:11571-6. 2003..human MHC molecules, revealed by nucleotide sequencing but not by serologic typing, substantially influence graft rejection and graft-versus-host disease, two serious complications of clinical HCT...
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2000..The knowledge gained from these studies could also be applied to other tissues and organs accessible to ultrasound. ..
- Signaling in Thymocyte SelectionGerald R Crabtree; Fiscal Year: 2010..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..
- Transplantation tolerance and immune function following mTOR inhibition.Jonathan D Powell; Fiscal Year: 2010..successful nonmyeloablative transplant to treat sickle cell anemia has been limited due to immune-mediated graft rejection. Our research has demonstrated that rapamycin can promote regulatory T cell (Treg) differentiation of naive T ..
- Sphingosine 1-phosphate receptors in vascular homeostasis and pathologyTIMOTHY TUN HLA; Fiscal Year: 2010..These studies are expected to derive critical insights into the workings of S1P receptors, which are important drug targets to control the vascular and immune systems. ..
- The immunobiology of CD4+ CD25+ T regulatory cellsThomas R Malek; Fiscal Year: 2011..Understanding the factors that reverse autoimmunity in the IL-2Rb- deficient model may also provide new information concerning the etiology and potential therapy that may be generally common to several human autoimmune diseases. ..
- Transplantation: Alloimmune NetworksDAVID LINN contact PERKINS; Fiscal Year: 2010Our goal is to understand the molecular interactions that regulate the immune response during graft rejection. Multiple studies indicate that graft rejection is complex, polygenic and poorly understood...
- T cell regulation by IDO-competent plasmacytoid dendritic cellsAndrew Mellor; Fiscal Year: 2009..This observation provides a rationale for treating mice with donor allograft and self-antigens to induce tolerance that will protect skin grafts and pancreatic islet cells from T cell mediated destruction. 1 ..
- Sustained release calcineurin inhibitors for the prevention of graft rejectionThomas Smith; Fiscal Year: 2007The long term goal of this research is to reduce toxicity and graft rejection due to dosing problems with the calcineurin inhibitors by developing sustained release subcutaneous injectable formulations for the drugs tacrolimus and ..
- Antiviral Therapy for Polyomavirus InfectionARON LUKACHER; Fiscal Year: 2007..g., FDA-approved Gleevec) limit polyomavirus infection, a critical prelude for their potential therapeutic use to prevent polyomavirus reactivation in immunosuppressed individuals. ..
- NOVEL THERAPIES FOR GRAFT REJECTION IN SENSITIZED HOSTSJerzy Kupiec Weglinski; Fiscal Year: 1999..The functional significance of host humoral reactivity will be probed by testing sera samples in CDC, ADCC, and in passive transfer studies. The effects of sera on the alloreactive T cell functions will be evaluated in MLR. ..
- Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant RejectionAnupam Agarwal; Fiscal Year: 2007..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
- Mechanisms of Acquired Central Transplantation ToleranceJames Markmann; Fiscal Year: 2003..In sharp contrast, the TS1 line is uniquely suited for the study of graft rejection and transplantation tolerance...
- Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant RejectionAnupam Agarwal; Fiscal Year: 2010..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
- Analyses of neutrophil interaction with immune complexesTanya N Mayadas; Fiscal Year: 2011..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
- Analyses of neutrophil interaction with immune complexesTanya N Mayadas; Fiscal Year: 2010..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
- Type V Collagen Prevents Lung Allograft RejectionDavid Wilkes; Fiscal Year: 2009..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
- Type V Collagen Prevents Lung Allograft RejectionDavid Wilkes; Fiscal Year: 2007..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
- Type V Collagen Prevents Lung Allograft RejectionDavid S Wilkes; Fiscal Year: 2010..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
- A New Pathway for Neutrophil-induced Airway InflammationJ Edwin Blalock; Fiscal Year: 2010..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. ..
- CXCL10/CXCR3 Signaling Regulates TLR4-Mediated Liver Inflamation and InjuryYuan Zhai; Fiscal Year: 2010..clinical settings and contributes to patient morbidity/mortality by causing primary liver failure and graft rejection. However, despite extensive research of the disease pathogenesis over the years, no effective therapies are ..
- Analysis of T cell epitope repertoireYoram Louzoun; Fiscal Year: 2007..This part of the research will be done in colaboration with an experimental group studying the B and T cell repertoire in autoimmunity. ..
- Role of VEGF in Glomerular Endothelial Health & DiseasesS Karumanchi; Fiscal Year: 2007..abstract_text> ..
- Movement of Recipient T-Cells Away From an AllograftMark Poznansky; Fiscal Year: 2003..To date therapeutic control over both acute and chronic graft rejection has been achieved predominantly with immunosuppressive agents targeted against the function of activated ..
- Graft Rejection and Accommodation by anti-Gal mAbsAnita Chong; Fiscal Year: 2006..We will use this model to investigate the mechanisms by which anti-Gal mAbs elicit graft rejection or induce accommodation...
- Role of NF-kB activation in acute allograft rejectionMaria Luisa Alegre; Fiscal Year: 2010..In this application we propose to investigate the mechanisms by which TCR-CARMA1-NF-?B regulates formation of nTregs, iTregs and Th17 cells and how these effects impact allograft fate. ..
- Role of autoimmunity in transplant rejectionGilles Benichou; Fiscal Year: 2007..in heart-transplanted individuals, the CD4 pathway of alloresponse contributes to acute and/or chronic heart graft rejection by triggering autoimmune responses to CM thereby causing cardiac tissue damages in a fashion similar to that ..
- Optimizing Nonmyeloablative Stem Cell TransplantationMarco Mielcarek; Fiscal Year: 2007..Most nonablative conditioning regimens contain irradiation, which is thought to be required to prevent graft rejection. However, low doses of irradiation are associated with increased risks of late malignancies, and avoiding ..
- Novel Biologic Therapies for BMT: Mechanistic Evaluation in Rhesus MacaquesLeslie S Kean; Fiscal Year: 2010..Three major complications have plagued the implementation of AD-BMT. They are: (1) The increased risk of graft rejection. (2) The high rate of acute graft-versus-host-disease (aGvHD) that occurs in the setting of MHC-mismatched ..
- Oral infection and inflammation in transplant patientsAnna Dongari Bagtzoglou; Fiscal Year: 2005....
- ENGRAFTING SENSITIZED HOSTS WITH NONABLATIVE REGIMENSRichard Nash; Fiscal Year: 2002..with blood products become sensitized to donor minor histocompatibility antigens, increasing the risk of graft rejection. Patients with inherited red blood cell diseases require blood transfusions and have a higher probability of ..
- ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLYJoyce Solheim; Fiscal Year: 2009..abstract_text> ..