Genomes and Genes
Summary: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Publications345 found, 100 shown here
- The Banff 97 working classification of renal allograft pathologyL C Racusen
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Kidney Int 55:713-23. 1999..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
- Reduced exposure to calcineurin inhibitors in renal transplantationHenrik Ekberg
Lund University, Malmo, Sweden
N Engl J Med 357:2562-75. 2007..Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens...
- Improved graft survival after renal transplantation in the United States, 1988 to 1996S Hariharan
Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
N Engl J Med 342:605-12. 2000..The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known...
- Banff 07 classification of renal allograft pathology: updates and future directionsK Solez
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
Am J Transplant 8:753-60. 2008....
- The natural history of chronic allograft nephropathyBrian J Nankivell
Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
N Engl J Med 349:2326-33. 2003..With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure...
- Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative settingAlma J Nauta
Laboratory of Experimental Hematology, Department of Hematology, D2 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Blood 108:2114-20. 2006..These properties may be of therapeutic value in allogeneic transplantation to prevent graft rejection and to prevent and treat graft-versus-host disease...
- Tolerogenic dendritic cells and their role in transplantationMohamed Ezzelarab
Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
Semin Immunol 23:252-63. 2011..Evaluation of technical and therapeutic logistic issues is an important next step prior to the application of tolerogenic DC in clinical organ transplantation...
- Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cellsManuela Battaglia
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
Blood 105:4743-8. 2005Rapamycin is an immunosuppressive compound that is currently used to prevent acute graft rejection in humans. In addition, rapamycin has been shown to allow operational tolerance in murine models...
- Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft toleranceW Ge
Department of Surgery, The University of Western Ontario, London, Ontario, Canada
Am J Transplant 9:1760-72. 2009..This study supports the clinical applicability of MSCs in transplantation...
- Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent eraHerwig Ulf Meier-Kriesche
University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
Am J Transplant 4:378-83. 2004..However, the etiology of this concerning trend for worse death censored graft survival in recent years will warrant further investigation...
- In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cellsSatish N Nadig
Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
Nat Med 16:809-13. 2010..We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy...
- A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)A Durrbach
Bicetre Hospital, Kremlin Bicetre, IFRNT, Universite Paris Sud, France
Am J Transplant 10:547-57. 2010....
- Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat modelPaolo Sbano
Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Siena, Italy
Arch Dermatol Res 300:115-24. 2008..Results of our study in a rat tissue transplantation model demonstrated a possible immunogenic role for donor (allogeneic) MSC, confirming the need of adequate preclinical experimentation before clinical use...
- Preexisting donor-specific HLA antibodies predict outcome in kidney transplantationCarmen Lefaucheur
Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
J Am Soc Nephrol 21:1398-406. 2010..Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients...
- Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primatesBernhard J Hering
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
Nat Med 12:301-3. 2006....
- Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolateF C Popp
Department of Surgery, University of Regensburg, Franz Josef Strauss Allee, 11 93053 Regensburg, Germany
Transpl Immunol 20:55-60. 2008..In summary, we demonstrate that MSC constitute a promising tool for induction of non-responsiveness in solid organ transplantation that warrants further investigation in clinical trials...
- Mast cells are essential intermediaries in regulatory T-cell toleranceLi Fan Lu
Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
Nature 442:997-1002. 2006..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
- Immunosuppressive drugs for kidney transplantationPhilip F Halloran
Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
N Engl J Med 351:2715-29. 2004
- CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primatesA D Kirk
Division of Transplantation, University of Wisconsin Hospital, Madison, WI 53792, USA
Proc Natl Acad Sci U S A 94:8789-94. 1997....
- Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantationL Fan
Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
Am J Transplant 11:911-22. 2011..In addition, these data indicate that neutralizing IL-17A or augmenting IL-10 could be therapeutic interventions to prevent OB...
- Diabetes mellitus after kidney transplantation in the United StatesBertram L Kasiske
The United States Renal Data System Coordinating Center, Minneapolis, MN, USA
Am J Transplant 3:178-85. 2003..It is a strong, independent predictor of graft failure and mortality. Efforts should be made to minimize the risk of this important complication...
- The Banff 2007 working classification of skin-containing composite tissue allograft pathologyL C Cendales
Emory Transplant Center, Emory University, Atlanta, GA, USA
Am J Transplant 8:1396-400. 2008..This classification refines proposed schemas, represents international consensus on this topic, and establishes a working collective classification system for CTA reporting of rejection in skin-containing CTAs...
- Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodiesA Loupy
INSERM UMR 872, Universite Paris Descartes, Paris, France
Am J Transplant 9:2561-70. 2009..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
- Heterologous immunity provides a potent barrier to transplantation toleranceAndrew B Adams
Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Clin Invest 111:1887-95. 2003..These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function...
- Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejectionLorraine C Racusen
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Transplant 3:708-14. 2003..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
- Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma productionStephen R Mattarollo
The University of Queensland Diamantina Institute, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
J Immunol 184:1242-50. 2010..Suppression of graft rejection is associated with the accumulation of CD1d(hi)-expressing CD11c(+)F4/80(hi) myeloid cells in hyperplastic ..
- Composite tissue allotransplantation: classification of clinical acute skin rejectionLinda C Cendales
Office of the Clinical Director, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Department of Health and Human Resources, Bethesda, MD 20892 1102, USA
Transplantation 81:418-22. 2006..However, a systematic examination of this process has not been performed, and there are no standardized criteria for the description of severity or type of rejection...
- Messenger RNA for FOXP3 in the urine of renal-allograft recipientsThangamani Muthukumar
Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York, USA
N Engl J Med 353:2342-51. 2005..The outcome of renal transplantation after an episode of acute rejection is difficult to predict, even with an allograft biopsy...
- Pediatric cardiac transplantation in children with high panel reactive antibodyJeffrey P Jacobs
The Congenital Heart Institute of Florida, All Children s Hospital, University of South Florida, St Petersburg, Florida, USA
Ann Thorac Surg 78:1703-9. 2004..We retrospectively reviewed our management strategy and outcome data for children undergoing heart transplantation with high PRA (> 10%)...
- Low levels of human leukocyte antigen donor-specific antibodies detected by solid phase assay before transplantation are frequently clinically irrelevantVincent Aubert
Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Hum Immunol 70:580-3. 2009..The only AHR episode occurred in a recipient with pretransplantation DSA. More work should be performed to better delineate the precise clinical significance of detecting low titers of DSA before transplantation...
- Xenotransplantation: current status and a perspective on the futureYong Guang Yang
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Nat Rev Immunol 7:519-31. 2007..This Review highlights the major obstacles impeding the translation of xenotransplantation into clinical therapies and the potential solutions, providing a perspective on the future of clinical xenotransplantation...
- Proteomic signatures in plasma during early acute renal allograft rejectionGabriela V Cohen Freue
Prevention of Organ Failure PROOF Centre of Excellence, Vancouver, British Columbia, Canada
Mol Cell Proteomics 9:1954-67. 2010Acute graft rejection is an important clinical problem in renal transplantation and an adverse predictor for long term graft survival...
- Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejectionSusan Stewart
Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
J Heart Lung Transplant 26:1229-42. 2007..This consensus revision of the working formulation was approved by the ISHLT board of directors in April 2007...
- Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injuryLeo E Otterbein
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
Nat Med 9:183-90. 2003..These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent...
- Gene-expression profiling for rejection surveillance after cardiac transplantationMichael X Pham
Stanford University Medical Center, Stanford, California, USA
N Engl J Med 362:1890-900. 2010..However, this procedure is uncomfortable, and there are risks associated with it. Gene-expression profiling of peripheral-blood specimens has been shown to correlate with the results of an endomyocardial biopsy...
- High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive responseLihua Duan
Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Lab Invest 91:43-53. 2011....
- Diagnosis and prevention of chronic kidney allograft lossBrian J Nankivell
Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
Lancet 378:1428-37. 2011..Strategies to maintain transplant function and improve long-term graft survival are important goals of translational research...
- The histology of solitary renal allografts at 1 and 5 years after transplantationM D Stegall
Von Liebig Transplant Center, Division of Transplantation Surgery, Division of Nephrology and Hypertension, Department of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
Am J Transplant 11:698-707. 2011..These results in the recent era of transplantation demonstrate fewer, less severe and less progressive chronic histologic changes in the first 5 years after transplantation than previously reported...
- Fibrosis with inflammation at one year predicts transplant functional declineWalter D Park
Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, USA
J Am Soc Nephrol 21:1987-97. 2010..Early interventions aimed at altering rejection-like inflammation may improve long-term survival of kidney allografts...
- Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansionSatoshi Itoh
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Circulation 124:S187-96. 2011..However, the precise role in allograft rejection remains uncertain. In the present study, we investigated the role of IL-17 in acute allograft rejection using IL-17-deficient mice...
- Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejectionChe Chuan Loong
Department of Surgery, Taipei Veterans General Hospital, Taiwan, ROC
J Pathol 197:322-32. 2002..These results demonstrate that hRECs exposed to IL-17 can produce inflammatory mediators with the potential to stimulate early alloimmune responses, which may also serve to give warning of acute renal allograft rejection...
- Predicting subsequent decline in kidney allograft function from early surveillance biopsiesFernando G Cosio
Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnnesota, USA
Am J Transplant 5:2464-72. 2005..In conclusion, inflammation and glomerulopathy 1 year post-transplant predict loss of graft function and graft failure independently of function and other variables...
- The T helper 17-regulatory T cell axis in transplant rejection and tolerancePeter Mitchell
Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London, UK
Curr Opin Organ Transplant 14:326-31. 2009..However, Tregs can be subverted by inflammatory conditions, resulting in a T helper 17 (Th17) cell response. This review looks at the relationship between Tregs and Th17 cells...
- Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantationDirk R J Kuypers
Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
Clin J Am Soc Nephrol 5:341-58. 2010..Although this consensus report does not evaluate the final role of MPA TDM in transplantation, it seeks to examine the current scientific evidence for concentration-controlled dosing of MPA...
- Universal noninvasive detection of solid organ transplant rejectionThomas M Snyder
Department of Applied Physics, Stanford University, Stanford, The Howard Hughes Medical Institute, CA 94305, USA
Proc Natl Acad Sci U S A 108:6229-34. 2011..This noninvasive test holds promise for replacing the endomyocardial biopsy in heart transplant recipients and may be applicable to other solid organ transplants...
- The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejectionStephanie Gras
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
Immunol Cell Biol 89:388-95. 2011..Here we review recent advances in the field, focusing on structural data pertaining to alloreactivity, and discuss the implications for T-cell-mediated transplant rejection...
- Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipientsHoward J Eisen
Section of Cardiology, Temple University, Philadelphia, PA 19140, USA
N Engl J Med 349:847-58. 2003..We conducted a randomized, double-blind, clinical trial comparing everolimus with azathioprine in recipients of a first heart transplant...
- Effect on kidney graft survival of reducing or discontinuing maintenance immunosuppression after the first year posttransplantGerhard Opelz
Transplantation 86:371-6. 2008..Data are scarce concerning the impact of maintenance immunosuppression dose reductions posttransplant...
- Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failureR B Mannon
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Transplant 10:2066-73. 2010..Phenotypic characterization of these inflammatory cells and appropriate treatment may ameliorate late allograft failure...
- Noninvasive detection of graft rejection by in vivo (19) F MRI in the early stageU Flogel
Cardiovascular Physiology, Heinrich Heine University Dusseldorf, Germany
Am J Transplant 11:235-44. 2011..Thus, PFCs can serve as positive contrast agent for the early detection of transplant rejection by (19) F MRI with high spatial resolution and an excellent degree of specificity due to lack of any (19) F background...
- Face transplantation: outcomes, concerns, controversies, and future directionsMaria Siemionow
Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Craniofac Surg 23:254-9. 2012..Since 2005, 17 facial allotransplantations have been performed worldwide. The brief summary of current cases with ongoing concerns is presented in this article...
- Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ TregsShipra Gupta
Harvard Medical School, Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Clin Invest 122:2395-404. 2012..The frequency and number of TIM-3+ Tregs peaked at the time of graft rejection and declined thereafter...
- A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathyXueli Yuan
Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 205:3133-44. 2008..These results have important implications for the development of novel therapies to target this intractable problem in clinical solid organ transplantation...
- Optimization of initial tacrolimus dose using pharmacogenetic testingE Thervet
Department of Renal Transplantation, Assistance Publique Hopitaux de Paris, Necker Enfants Malades Hospital, Paris, France
Clin Pharmacol Ther 87:721-6. 2010..Pharmacogenetic adaptation of the daily dose of tacrolimus is associated with improved achievement of the target C(0). Whether this improvement will affect clinical outcomes requires further evaluation...
- A molecular classifier for predicting future graft loss in late kidney transplant biopsiesGunilla Einecke
Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
J Clin Invest 120:1862-72. 2010..In an independent validation set, the molecular risk score was the only predictor of graft loss. Thus, the molecular risk score reflects active injury and is superior to either scarring or function in predicting graft failure...
- Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applicationsP Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
Scand J Rheumatol 39:1-11. 2010..In this review, we summarize certain aspects of the molecular background of autologous stem cell transplantation and also depict the response to therapy in various autoimmune and rheumatic diseases...
- Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')K Solez
University of Alberta, Edmonton, Alberta, Canada
Am J Transplant 7:518-26. 2007..Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference...
- Evaluation of a topical cyclosporine A prodrug on corneal graft rejection in ratsJ L Bourges
INSERM, U598, Paris, France
Mol Vis 12:1461-6. 2006..To assess the efficacy of a topical cyclosporine A (CsA), water-soluble prodrug, for promoting the survival of allogenic rat corneal grafts after penetrating keratoplasty (PKP)...
- Mechanisms involved in antibody- and complement-mediated allograft rejectionBarbara A Wasowska
Department of Pathology, The Johns Hopkins University School of Medicine, Ross Bldg 664B, Baltimore, MD 21205, USA
Immunol Res 47:25-44. 2010..transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of ..
- Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejectionJacopo Mariotti
Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 180:89-105. 2008..In a B6-into-BALB/c graft rejection model, donor Th2/Tc2...
- Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organsAlberto Sanchez-Fueyo
Liver Transplant Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
Gastroenterology 140:51-64. 2011..We review recently developed therapeutic strategies to promote tolerance to transplanted livers and other organs and diagnostic tools that might be used to identify patients most likely to accept or reject allografts...
- Cardiovascular mortality among heart transplant recipients with asymptomatic antibody-mediated or stable mixed cellular and antibody-mediated rejectionAbdallah G Kfoury
Intermountain Medical Center and Intermountain Healthcare, Salt Lake City, UT, USA
J Heart Lung Transplant 28:781-4. 2009..In this study, we examined whether a differential impact on cardiovascular mortality (CVM) existed when comparing asymptomatic AMR, to stable MR or CR...
- Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cellsRoss S Francis
Transplant Research Immunology Group, Nuffield Department of Surgery, University of Oxford John Radcliffe Hospital, Oxford, UK
Eur J Immunol 41:726-38. 2011....
- Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cellsPaolo Monti
Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
Diabetes 57:2341-7. 2008Rapamycin is an immunosuppressive drug currently used to prevent graft rejection in humans, which is considered permissive for tolerance induction...
- Proteinuria after kidney transplantation, relationship to allograft histology and survivalH Amer
Department of Internal Medicine, Division of Nephrology and Hypertension and Transplant Center, Mayo Clinic College of Medicine, Rochester, MN, USA
Am J Transplant 7:2748-56. 2007..However, and even low levels of proteinuria relate to poor graft survival. Proteinuria and glomerular pathology relate independently to survival...
- Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipientsPål Falck
Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway
Transplantation 85:179-84. 2008..We investigated cyclosporine A (CsA) concentrations at the site of action, inside T-lymphocytes, to evaluate its applicability as a new supplementary therapeutic drug monitoring method after renal transplantation...
- T-cell allorecognition and transplant rejection: a summary and updatePeter S Heeger
Department of Immunology and The Glickman Urologic Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
Am J Transplant 3:525-33. 2003....
- T-cell responses during pig-to-primate xenotransplantationEduardo Davila
Department of Pediatrics, Louisiana State University Health Science Center, Stanley S Scott Cancer Center, New Orleans, LA, USA
Xenotransplantation 13:31-40. 2006..To determine the potential role of T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46 porcine hearts heterotopically into baboon recipients...
- Factors contributing to acute rejection in renal transplantation: the role of noncomplianceP E Morrissey
Division of Organ Transplantation and Medical Statistics, Rhode Island Hospital, Brown Medical School, 593 Eddy Street APC 921, Providence, RI 02903, USA
Transplant Proc 37:2044-7. 2005..Future strategies to improve compliance, including increased vigilance in high-risk patient groups, frequent medication review, and laboratory testing, should be encouraged...
- Factors influencing renal function after liver transplantation. Results from the MOST, an international observational studyP Burra
Gastroenterology, Department of Surgical and Gastroenterological Sciences, University Hospital Padova, Padova, Italy
Dig Liver Dis 41:350-6. 2009..Given organ shortage it should be essential to determine which patients will experience progressive and severe renal dysfunction after liver transplantation (LT)...
- Enhancement of antitumor immunity by CTLA-4 blockadeD R Leach
Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
Science 271:1734-6. 1996..These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells...
- Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d stainingEnver Akalin
Renal Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Clin J Am Soc Nephrol 2:1261-7. 2007..We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms...
- Antibody-mediated rejection in kidney transplantation: an updateJessica G Lucas
Division of Nephrology and Hypertension, Department of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
Expert Opin Pharmacother 12:579-92. 2011..Acute antibody-mediated rejection (AMR) in renal-transplant recipients is generally less responsive to conventional antirejection therapy and has a worse prognosis than acute cellular rejection...
- Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomesGrace W Wu
Division of Cardiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 6988, USA
J Heart Lung Transplant 28:417-22. 2009..The significance of AMR findings in biopsy specimens of asymptomatic heart transplant patients (normal cardiac function and no symptoms of heart failure) is unclear...
- Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft functionE C Aquino-Dias
Post Graduate Medical Sciences Nephrology Program, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Kidney Int 73:877-84. 2008..Our study shows that quantification of selected genes in peripheral blood leukocytes and urinary cells from renal transplant patients with DGF may provide a useful and accurate non-invasive diagnosis of AR...
- Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cellsYi Ping Jin
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Hum Immunol 65:291-302. 2004..These results suggest that exposure of the graft endothelium to low concentrations of anti-HLA Ab may promote cell survival by transducing signals resulting in upregulation of cell survival genes...
- Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft lossF Moreso
Nephrology Department, Hospital Universitari de Bellvitge, IDIBELL Institut d Investigacio de Bellvitge, c Feixa Llarga s n, L Hospitalet 08907 Barcelona, Spain
Am J Transplant 6:747-52. 2006..27, 95% CI: 1.38-3.75; p = 0.01) were independent predictors of graft survival. In protocol biopsies, the detrimental effect of interstitial fibrosis/tubular atrophy on long-term graft survival is modulated by SCR...
- Pediatric heart transplantation in human leukocyte antigen sensitized patients: evolving management and assessment of intermediate-term outcomes in a high-risk populationStacey M Pollock-Barziv
Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children University of Toronto, Toronto, Ontario, Canada
Circulation 116:I172-8. 2007..We report our experience with human leukocyte antigens-sensitized pediatric HTx recipients...
- Plasmapheresis and cyclophosphamide in the treatment of humoral rejection after heart transplantationO Grauhan
Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
J Heart Lung Transplant 20:316-21. 2001..Clinical reports on humoral rejection after heart transplantation showed that these episodes were often more severe than those mediated through T lymphocytes and that the patient's prognosis was significantly worsened...
- Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant StudyDonald T H Tan
Singapore National Eye Centre, Singapore
Ophthalmology 115:975-982.e1. 2008..The indications, complications, long-term survival rates, and risk factors for graft failure of penetrating keratoplasty (PK) performed in Asian eyes are reported...
- ABO-incompatible heart transplantation in infantsL J West
Department of Paediatrics, Hospital for Sick Children and University of Toronto, ON, Canada
N Engl J Med 344:793-800. 2001..This contraindication may not apply to newborn infants, who do not yet produce antibodies to T-cell-independent antigens, including the major blood-group antigens...
- Role of immunoproteasomes in cross-presentationMichael J Palmowski
Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
J Immunol 177:983-90. 2006....
- The changing role of natural killer cells in solid organ rejection and toleranceWilliam H Kitchens
Division of Transplantation, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Transplantation 81:811-7. 2006..These new findings suggest that the role of NK cells in solid organ rejection and tolerance needs to be reexamined...
- Endothelial injury, alarmins, and allograft rejectionDeepak A Rao
Department of Immunobiology, Section of Human and Translational Immunology, Yale University School of Medicine, New Haven, CT 06520 8089, USA
Crit Rev Immunol 28:229-48. 2008....
- Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejectionBanu Sis
Department of Laboratory Medicine and Pathology, University of Alberta, Alberta, Canada
Curr Opin Organ Transplant 15:42-8. 2010..This article reviews recent molecular studies in kidney allograft tissues that decipher molecular burden and mechanisms of ABMR, leading to discovery of a new phenotype: 'C4d-negative ABMR'...
- Transplant glomerulopathy: risk and prognosis related to anti-human leukocyte antigen class II antibody levelsNaim Issa
Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Transplantation 86:681-5. 2008..The goal of this study was to determine the relationships among antibody characteristics (level and specificity), risk for TG, and graft survival...
- In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantationRutger Jan Swijnenburg
Department of Cardiothoracic Surgery, Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA
Stem Cells Dev 17:1023-9. 2008..These data show that mESCs do not retain immune-privileged properties in vivo and are subject to immunological rejection as assessed by novel molecular imaging approaches...
- Anti-HLA donor-specific antibodies detected in positive B-cell crossmatches by Luminex predict late graft lossH S Eng
Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia
Am J Transplant 8:2335-42. 2008..Thus, using BXM to preclude kidney transplantation may potentially disadvantage >60% of patients in whom BXM is not indicative of the presence of DSA...
- TIM-1 and TIM-3 proteins in immune regulationEe Wern Su
Department of Immunology, University of Pittsburgh, 200 Lothrop Street, BST E 1056, Pittsburgh, PA 15261, USA
Cytokine 44:9-13. 2008..We therefore propose that the definition of TIM be adjusted to "transmembrane immunoglobulin and mucin"...
- Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboonsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
Am J Pathol 172:1471-81. 2008....
- Airway epithelium is the primary target of allograft rejection in murine obliterative airway diseaseFelix G Fernandez
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
Am J Transplant 4:319-25. 2004..This indicates that the airway epithelium plays a crucial role in OAD development...
- Abrogation of anti-HLA antibodies via proteasome inhibitionHargovind L Trivedi
Department of Nephrology and Transplantation Medicine, Institute of Kidney Diseases and Research Centre Institute of Transplantation Sciences, Ahmedabad, Gujarat, India
Transplantation 87:1555-61. 2009..We report the first clinical experience with a plasma cell depleting therapy, bortezomib, to abrogate anti-HLA antibodies in transplantation (outside of rejection) in an attempt to improve long-term allograft survival...
- Bortezomib provides effective therapy for antibody- and cell-mediated acute rejectionMatthew J Everly
Department of Surgery, Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
Transplantation 86:1754-61. 2008..We report the first clinical experience with plasma cell-targeted therapy (bortezomib) as an antirejection strategy...
- Pathways of allorecognition: implications for transplantation toleranceDavid S Game
Department of Immunology, Imperial College School of Medicine, London, UK
Transpl Immunol 10:101-8. 2002..It is hoped that the careful study of these mechanisms will reveal ways of ensuring allorecognition without activation and thus donor-specific tolerance...
- Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urineB Li
Department of Medicine, Weill Medical College of Cornell University, New York, USA
N Engl J Med 344:947-54. 2001..CONCLUSIONS: Measurement of mRNA encoding cytotoxic proteins in urinary cells offers a noninvasive means of diagnosing acute rejection of renal allografts...
- Antibody testing for cardiac antibody-mediated rejection: which panel correlates best with cardiovascular death?Monica P Revelo
George E Wahlen Veterans Affairs Medical Center, Utah Transplantation Affiliated Hospitals, Salt Lake City, Utah, USA
J Heart Lung Transplant 30:144-50. 2011....
- A systematic review on steroid withdrawal between 3 and 6 months after kidney transplantationJulio Pascual
Servicio de Nefrologia, Hospital del Mar, Institut Municipal d Asistencia Sanitaria, Universitat Autonoma de Barcelona, Barcelona, Spain
Transplantation 90:343-9. 2010..Steroid withdrawal (SW) after the first posttransplant months in patients receiving a kidney transplant has been recently discouraged in clinical guidelines...
- Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant recipientsTajinder P Singh
Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Heart Lung Transplant 29:517-22. 2010..In this study, we report early clinical outcomes in a cohort of pediatric heart transplant recipients managed using a steroid-avoidance protocol...
- Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantationJ M Gloor
Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Am J Transplant 10:582-9. 2010..With current protocols, very high baseline DSA patients have high rates of AMR and poor long-term allograft survival highlighting the need for improved therapy for these candidates...
- Shotgun proteomics identifies proteins specific for acute renal transplant rejectionTara K Sigdel
Department of Pediatrics, Stanford University School of Medicine, CA 94304, USA
Proteomics Clin Appl 4:32-47. 2010..Acute rejection (AR) remains the primary risk factor for renal transplant outcome; development of non-invasive diagnostic biomarkers for AR is an unmet need...
- Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: an analysis of the United Network for Organ Sharing databaseJoseph W Rossano
Department of Pediatrics, Lillie Frank Abercrombie Section of Pediatric Cardiology, Baylor College of Medicine, Texas Children s Hospital, Houston, Tex 77030, USA
J Thorac Cardiovasc Surg 140:694-9, 699.e1-2. 2010..This study sought to determine the association of elevated anti-human leukocyte antibodies with long-term survival in pediatric heart transplant patients...
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2000..The knowledge gained from these studies could also be applied to other tissues and organs accessible to ultrasound. ..
- Signaling in Thymocyte SelectionGerald R Crabtree; Fiscal Year: 2010..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..
- Transplantation tolerance and immune function following mTOR inhibition.Jonathan D Powell; Fiscal Year: 2010..successful nonmyeloablative transplant to treat sickle cell anemia has been limited due to immune-mediated graft rejection. Our research has demonstrated that rapamycin can promote regulatory T cell (Treg) differentiation of naive T ..
- Sphingosine 1-phosphate receptors in vascular homeostasis and pathologyTIMOTHY TUN HLA; Fiscal Year: 2010..These studies are expected to derive critical insights into the workings of S1P receptors, which are important drug targets to control the vascular and immune systems. ..
- The immunobiology of CD4+ CD25+ T regulatory cellsThomas R Malek; Fiscal Year: 2011..Understanding the factors that reverse autoimmunity in the IL-2Rb- deficient model may also provide new information concerning the etiology and potential therapy that may be generally common to several human autoimmune diseases. ..
- Transplantation: Alloimmune NetworksDAVID LINN contact PERKINS; Fiscal Year: 2010Our goal is to understand the molecular interactions that regulate the immune response during graft rejection. Multiple studies indicate that graft rejection is complex, polygenic and poorly understood...
- T cell regulation by IDO-competent plasmacytoid dendritic cellsAndrew Mellor; Fiscal Year: 2009..This observation provides a rationale for treating mice with donor allograft and self-antigens to induce tolerance that will protect skin grafts and pancreatic islet cells from T cell mediated destruction. 1 ..
- Antiviral Therapy for Polyomavirus InfectionARON LUKACHER; Fiscal Year: 2007..g., FDA-approved Gleevec) limit polyomavirus infection, a critical prelude for their potential therapeutic use to prevent polyomavirus reactivation in immunosuppressed individuals. ..
- Sustained release calcineurin inhibitors for the prevention of graft rejectionThomas Smith; Fiscal Year: 2007The long term goal of this research is to reduce toxicity and graft rejection due to dosing problems with the calcineurin inhibitors by developing sustained release subcutaneous injectable formulations for the drugs tacrolimus and ..
- NOVEL THERAPIES FOR GRAFT REJECTION IN SENSITIZED HOSTSJerzy Kupiec Weglinski; Fiscal Year: 1999..The functional significance of host humoral reactivity will be probed by testing sera samples in CDC, ADCC, and in passive transfer studies. The effects of sera on the alloreactive T cell functions will be evaluated in MLR. ..
- Mechanisms of Acquired Central Transplantation ToleranceJames Markmann; Fiscal Year: 2003..In sharp contrast, the TS1 line is uniquely suited for the study of graft rejection and transplantation tolerance...
- Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant RejectionAnupam Agarwal; Fiscal Year: 2010..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
- Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant RejectionAnupam Agarwal; Fiscal Year: 2007..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
- Analyses of neutrophil interaction with immune complexesTanya N Mayadas; Fiscal Year: 2011..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
- Analyses of neutrophil interaction with immune complexesTanya N Mayadas; Fiscal Year: 2010..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
- Type V Collagen Prevents Lung Allograft RejectionDavid S Wilkes; Fiscal Year: 2010..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
- Type V Collagen Prevents Lung Allograft RejectionDavid Wilkes; Fiscal Year: 2009..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
- Type V Collagen Prevents Lung Allograft RejectionDavid Wilkes; Fiscal Year: 2007..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
- A New Pathway for Neutrophil-induced Airway InflammationJ Edwin Blalock; Fiscal Year: 2010..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. ..
- Analysis of T cell epitope repertoireYoram Louzoun; Fiscal Year: 2007..This part of the research will be done in colaboration with an experimental group studying the B and T cell repertoire in autoimmunity. ..
- CXCL10/CXCR3 Signaling Regulates TLR4-Mediated Liver Inflamation and InjuryYuan Zhai; Fiscal Year: 2010..clinical settings and contributes to patient morbidity/mortality by causing primary liver failure and graft rejection. However, despite extensive research of the disease pathogenesis over the years, no effective therapies are ..
- Role of VEGF in Glomerular Endothelial Health & DiseasesS Karumanchi; Fiscal Year: 2007..abstract_text> ..
- Movement of Recipient T-Cells Away From an AllograftMark Poznansky; Fiscal Year: 2003..To date therapeutic control over both acute and chronic graft rejection has been achieved predominantly with immunosuppressive agents targeted against the function of activated ..
- Graft Rejection and Accommodation by anti-Gal mAbsAnita Chong; Fiscal Year: 2006..We will use this model to investigate the mechanisms by which anti-Gal mAbs elicit graft rejection or induce accommodation...
- Role of NF-kB activation in acute allograft rejectionMaria Luisa Alegre; Fiscal Year: 2010..In this application we propose to investigate the mechanisms by which TCR-CARMA1-NF-?B regulates formation of nTregs, iTregs and Th17 cells and how these effects impact allograft fate. ..
- Optimizing Nonmyeloablative Stem Cell TransplantationMarco Mielcarek; Fiscal Year: 2007..Most nonablative conditioning regimens contain irradiation, which is thought to be required to prevent graft rejection. However, low doses of irradiation are associated with increased risks of late malignancies, and avoiding ..
- Novel Biologic Therapies for BMT: Mechanistic Evaluation in Rhesus MacaquesLeslie S Kean; Fiscal Year: 2010..Three major complications have plagued the implementation of AD-BMT. They are: (1) The increased risk of graft rejection. (2) The high rate of acute graft-versus-host-disease (aGvHD) that occurs in the setting of MHC-mismatched ..
- Role of autoimmunity in transplant rejectionGilles Benichou; Fiscal Year: 2007..in heart-transplanted individuals, the CD4 pathway of alloresponse contributes to acute and/or chronic heart graft rejection by triggering autoimmune responses to CM thereby causing cardiac tissue damages in a fashion similar to that ..
- Oral infection and inflammation in transplant patientsAnna Dongari Bagtzoglou; Fiscal Year: 2005....
- ENGRAFTING SENSITIZED HOSTS WITH NONABLATIVE REGIMENSRichard Nash; Fiscal Year: 2002..with blood products become sensitized to donor minor histocompatibility antigens, increasing the risk of graft rejection. Patients with inherited red blood cell diseases require blood transfusions and have a higher probability of ..
- ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLYJoyce Solheim; Fiscal Year: 2009..abstract_text> ..