graft rejection

Summary

Summary: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.

Top Publications

  1. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
  2. ncbi Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
  3. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
  4. doi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
  5. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
  6. pmc Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting
    Alma J Nauta
    Laboratory of Experimental Hematology, Department of Hematology, D2 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Blood 108:2114-20. 2006
  7. pmc Tolerogenic dendritic cells and their role in transplantation
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
    Semin Immunol 23:252-63. 2011
  8. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
  9. doi Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance
    W Ge
    Department of Surgery, The University of Western Ontario, London, Ontario, Canada
    Am J Transplant 9:1760-72. 2009
  10. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004

Detail Information

Publications345 found, 100 shown here

  1. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
    ..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
  2. ncbi Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
    ..Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens...
  3. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
    ..The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known...
  4. doi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
    ....
  5. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
    ..With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure...
  6. pmc Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting
    Alma J Nauta
    Laboratory of Experimental Hematology, Department of Hematology, D2 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Blood 108:2114-20. 2006
    ..These properties may be of therapeutic value in allogeneic transplantation to prevent graft rejection and to prevent and treat graft-versus-host disease...
  7. pmc Tolerogenic dendritic cells and their role in transplantation
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
    Semin Immunol 23:252-63. 2011
    ..Evaluation of technical and therapeutic logistic issues is an important next step prior to the application of tolerogenic DC in clinical organ transplantation...
  8. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    Rapamycin is an immunosuppressive compound that is currently used to prevent acute graft rejection in humans. In addition, rapamycin has been shown to allow operational tolerance in murine models...
  9. doi Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance
    W Ge
    Department of Surgery, The University of Western Ontario, London, Ontario, Canada
    Am J Transplant 9:1760-72. 2009
    ..This study supports the clinical applicability of MSCs in transplantation...
  10. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004
    ..However, the etiology of this concerning trend for worse death censored graft survival in recent years will warrant further investigation...
  11. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
    ..We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy...
  12. doi A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
    A Durrbach
    Bicetre Hospital, Kremlin Bicetre, IFRNT, Universite Paris Sud, France
    Am J Transplant 10:547-57. 2010
    ....
  13. doi Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model
    Paolo Sbano
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Siena, Italy
    Arch Dermatol Res 300:115-24. 2008
    ..Results of our study in a rat tissue transplantation model demonstrated a possible immunogenic role for donor (allogeneic) MSC, confirming the need of adequate preclinical experimentation before clinical use...
  14. pmc Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation
    Carmen Lefaucheur
    Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 21:1398-406. 2010
    ..Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients...
  15. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  16. doi Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate
    F C Popp
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee, 11 93053 Regensburg, Germany
    Transpl Immunol 20:55-60. 2008
    ..In summary, we demonstrate that MSC constitute a promising tool for induction of non-responsiveness in solid organ transplantation that warrants further investigation in clinical trials...
  17. ncbi Mast cells are essential intermediaries in regulatory T-cell tolerance
    Li Fan Lu
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Nature 442:997-1002. 2006
    ..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
  18. ncbi Immunosuppressive drugs for kidney transplantation
    Philip F Halloran
    Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    N Engl J Med 351:2715-29. 2004
  19. pmc CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    A D Kirk
    Division of Transplantation, University of Wisconsin Hospital, Madison, WI 53792, USA
    Proc Natl Acad Sci U S A 94:8789-94. 1997
    ....
  20. pmc Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
    L Fan
    Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
    Am J Transplant 11:911-22. 2011
    ..In addition, these data indicate that neutralizing IL-17A or augmenting IL-10 could be therapeutic interventions to prevent OB...
  21. ncbi Diabetes mellitus after kidney transplantation in the United States
    Bertram L Kasiske
    The United States Renal Data System Coordinating Center, Minneapolis, MN, USA
    Am J Transplant 3:178-85. 2003
    ..It is a strong, independent predictor of graft failure and mortality. Efforts should be made to minimize the risk of this important complication...
  22. doi The Banff 2007 working classification of skin-containing composite tissue allograft pathology
    L C Cendales
    Emory Transplant Center, Emory University, Atlanta, GA, USA
    Am J Transplant 8:1396-400. 2008
    ..This classification refines proposed schemas, represents international consensus on this topic, and establishes a working collective classification system for CTA reporting of rejection in skin-containing CTAs...
  23. doi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  24. pmc Heterologous immunity provides a potent barrier to transplantation tolerance
    Andrew B Adams
    Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 111:1887-95. 2003
    ..These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function...
  25. ncbi Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection
    Lorraine C Racusen
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 3:708-14. 2003
    ..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
  26. doi Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production
    Stephen R Mattarollo
    The University of Queensland Diamantina Institute, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    J Immunol 184:1242-50. 2010
    ..Suppression of graft rejection is associated with the accumulation of CD1d(hi)-expressing CD11c(+)F4/80(hi) myeloid cells in hyperplastic ..
  27. ncbi Composite tissue allotransplantation: classification of clinical acute skin rejection
    Linda C Cendales
    Office of the Clinical Director, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Department of Health and Human Resources, Bethesda, MD 20892 1102, USA
    Transplantation 81:418-22. 2006
    ..However, a systematic examination of this process has not been performed, and there are no standardized criteria for the description of severity or type of rejection...
  28. ncbi Messenger RNA for FOXP3 in the urine of renal-allograft recipients
    Thangamani Muthukumar
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 353:2342-51. 2005
    ..The outcome of renal transplantation after an episode of acute rejection is difficult to predict, even with an allograft biopsy...
  29. ncbi Pediatric cardiac transplantation in children with high panel reactive antibody
    Jeffrey P Jacobs
    The Congenital Heart Institute of Florida, All Children s Hospital, University of South Florida, St Petersburg, Florida, USA
    Ann Thorac Surg 78:1703-9. 2004
    ..We retrospectively reviewed our management strategy and outcome data for children undergoing heart transplantation with high PRA (> 10%)...
  30. doi Low levels of human leukocyte antigen donor-specific antibodies detected by solid phase assay before transplantation are frequently clinically irrelevant
    Vincent Aubert
    Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Hum Immunol 70:580-3. 2009
    ..The only AHR episode occurred in a recipient with pretransplantation DSA. More work should be performed to better delineate the precise clinical significance of detecting low titers of DSA before transplantation...
  31. ncbi Xenotransplantation: current status and a perspective on the future
    Yong Guang Yang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Rev Immunol 7:519-31. 2007
    ..This Review highlights the major obstacles impeding the translation of xenotransplantation into clinical therapies and the potential solutions, providing a perspective on the future of clinical xenotransplantation...
  32. pmc Proteomic signatures in plasma during early acute renal allograft rejection
    Gabriela V Cohen Freue
    Prevention of Organ Failure PROOF Centre of Excellence, Vancouver, British Columbia, Canada
    Mol Cell Proteomics 9:1954-67. 2010
    Acute graft rejection is an important clinical problem in renal transplantation and an adverse predictor for long term graft survival...
  33. ncbi Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection
    Susan Stewart
    Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 26:1229-42. 2007
    ..This consensus revision of the working formulation was approved by the ISHLT board of directors in April 2007...
  34. ncbi Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
    Leo E Otterbein
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
    Nat Med 9:183-90. 2003
    ..These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent...
  35. doi Gene-expression profiling for rejection surveillance after cardiac transplantation
    Michael X Pham
    Stanford University Medical Center, Stanford, California, USA
    N Engl J Med 362:1890-900. 2010
    ..However, this procedure is uncomfortable, and there are risks associated with it. Gene-expression profiling of peripheral-blood specimens has been shown to correlate with the results of an endomyocardial biopsy...
  36. doi High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response
    Lihua Duan
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Lab Invest 91:43-53. 2011
    ....
  37. doi Diagnosis and prevention of chronic kidney allograft loss
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    Lancet 378:1428-37. 2011
    ..Strategies to maintain transplant function and improve long-term graft survival are important goals of translational research...
  38. doi The histology of solitary renal allografts at 1 and 5 years after transplantation
    M D Stegall
    Von Liebig Transplant Center, Division of Transplantation Surgery, Division of Nephrology and Hypertension, Department of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 11:698-707. 2011
    ..These results in the recent era of transplantation demonstrate fewer, less severe and less progressive chronic histologic changes in the first 5 years after transplantation than previously reported...
  39. pmc Fibrosis with inflammation at one year predicts transplant functional decline
    Walter D Park
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Nephrol 21:1987-97. 2010
    ..Early interventions aimed at altering rejection-like inflammation may improve long-term survival of kidney allografts...
  40. doi Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circulation 124:S187-96. 2011
    ..However, the precise role in allograft rejection remains uncertain. In the present study, we investigated the role of IL-17 in acute allograft rejection using IL-17-deficient mice...
  41. ncbi Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection
    Che Chuan Loong
    Department of Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Pathol 197:322-32. 2002
    ..These results demonstrate that hRECs exposed to IL-17 can produce inflammatory mediators with the potential to stimulate early alloimmune responses, which may also serve to give warning of acute renal allograft rejection...
  42. ncbi Predicting subsequent decline in kidney allograft function from early surveillance biopsies
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnnesota, USA
    Am J Transplant 5:2464-72. 2005
    ..In conclusion, inflammation and glomerulopathy 1 year post-transplant predict loss of graft function and graft failure independently of function and other variables...
  43. doi The T helper 17-regulatory T cell axis in transplant rejection and tolerance
    Peter Mitchell
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London, UK
    Curr Opin Organ Transplant 14:326-31. 2009
    ..However, Tregs can be subverted by inflammatory conditions, resulting in a T helper 17 (Th17) cell response. This review looks at the relationship between Tregs and Th17 cells...
  44. doi Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:341-58. 2010
    ..Although this consensus report does not evaluate the final role of MPA TDM in transplantation, it seeks to examine the current scientific evidence for concentration-controlled dosing of MPA...
  45. pmc Universal noninvasive detection of solid organ transplant rejection
    Thomas M Snyder
    Department of Applied Physics, Stanford University, Stanford, The Howard Hughes Medical Institute, CA 94305, USA
    Proc Natl Acad Sci U S A 108:6229-34. 2011
    ..This noninvasive test holds promise for replacing the endomyocardial biopsy in heart transplant recipients and may be applicable to other solid organ transplants...
  46. doi The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection
    Stephanie Gras
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 89:388-95. 2011
    ..Here we review recent advances in the field, focusing on structural data pertaining to alloreactivity, and discuss the implications for T-cell-mediated transplant rejection...
  47. ncbi Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
    Howard J Eisen
    Section of Cardiology, Temple University, Philadelphia, PA 19140, USA
    N Engl J Med 349:847-58. 2003
    ..We conducted a randomized, double-blind, clinical trial comparing everolimus with azathioprine in recipients of a first heart transplant...
  48. doi Effect on kidney graft survival of reducing or discontinuing maintenance immunosuppression after the first year posttransplant
    Gerhard Opelz
    Transplantation 86:371-6. 2008
    ..Data are scarce concerning the impact of maintenance immunosuppression dose reductions posttransplant...
  49. pmc Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure
    R B Mannon
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Transplant 10:2066-73. 2010
    ..Phenotypic characterization of these inflammatory cells and appropriate treatment may ameliorate late allograft failure...
  50. doi Noninvasive detection of graft rejection by in vivo (19) F MRI in the early stage
    U Flogel
    Cardiovascular Physiology, Heinrich Heine University Dusseldorf, Germany
    Am J Transplant 11:235-44. 2011
    ..Thus, PFCs can serve as positive contrast agent for the early detection of transplant rejection by (19) F MRI with high spatial resolution and an excellent degree of specificity due to lack of any (19) F background...
  51. doi Face transplantation: outcomes, concerns, controversies, and future directions
    Maria Siemionow
    Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Craniofac Surg 23:254-9. 2012
    ..Since 2005, 17 facial allotransplantations have been performed worldwide. The brief summary of current cases with ongoing concerns is presented in this article...
  52. pmc Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs
    Shipra Gupta
    Harvard Medical School, Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Invest 122:2395-404. 2012
    ..The frequency and number of TIM-3+ Tregs peaked at the time of graft rejection and declined thereafter...
  53. pmc A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy
    Xueli Yuan
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:3133-44. 2008
    ..These results have important implications for the development of novel therapies to target this intractable problem in clinical solid organ transplantation...
  54. doi Optimization of initial tacrolimus dose using pharmacogenetic testing
    E Thervet
    Department of Renal Transplantation, Assistance Publique Hopitaux de Paris, Necker Enfants Malades Hospital, Paris, France
    Clin Pharmacol Ther 87:721-6. 2010
    ..Pharmacogenetic adaptation of the daily dose of tacrolimus is associated with improved achievement of the target C(0). Whether this improvement will affect clinical outcomes requires further evaluation...
  55. pmc A molecular classifier for predicting future graft loss in late kidney transplant biopsies
    Gunilla Einecke
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
    J Clin Invest 120:1862-72. 2010
    ..In an independent validation set, the molecular risk score was the only predictor of graft loss. Thus, the molecular risk score reflects active injury and is superior to either scarring or function in predicting graft failure...
  56. doi Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applications
    P Szodoray
    Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
    Scand J Rheumatol 39:1-11. 2010
    ..In this review, we summarize certain aspects of the molecular background of autologous stem cell transplantation and also depict the response to therapy in various autoimmune and rheumatic diseases...
  57. ncbi Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')
    K Solez
    University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:518-26. 2007
    ..Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference...
  58. ncbi Evaluation of a topical cyclosporine A prodrug on corneal graft rejection in rats
    J L Bourges
    INSERM, U598, Paris, France
    Mol Vis 12:1461-6. 2006
    ..To assess the efficacy of a topical cyclosporine A (CsA), water-soluble prodrug, for promoting the survival of allogenic rat corneal grafts after penetrating keratoplasty (PKP)...
  59. pmc Mechanisms involved in antibody- and complement-mediated allograft rejection
    Barbara A Wasowska
    Department of Pathology, The Johns Hopkins University School of Medicine, Ross Bldg 664B, Baltimore, MD 21205, USA
    Immunol Res 47:25-44. 2010
    ..transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of ..
  60. ncbi Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection
    Jacopo Mariotti
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:89-105. 2008
    ..In a B6-into-BALB/c graft rejection model, donor Th2/Tc2...
  61. pmc Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs
    Alberto Sanchez-Fueyo
    Liver Transplant Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
    Gastroenterology 140:51-64. 2011
    ..We review recently developed therapeutic strategies to promote tolerance to transplanted livers and other organs and diagnostic tools that might be used to identify patients most likely to accept or reject allografts...
  62. doi Cardiovascular mortality among heart transplant recipients with asymptomatic antibody-mediated or stable mixed cellular and antibody-mediated rejection
    Abdallah G Kfoury
    Intermountain Medical Center and Intermountain Healthcare, Salt Lake City, UT, USA
    J Heart Lung Transplant 28:781-4. 2009
    ..In this study, we examined whether a differential impact on cardiovascular mortality (CVM) existed when comparing asymptomatic AMR, to stable MR or CR...
  63. pmc Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells
    Ross S Francis
    Transplant Research Immunology Group, Nuffield Department of Surgery, University of Oxford John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 41:726-38. 2011
    ....
  64. pmc Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
    Paolo Monti
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 57:2341-7. 2008
    Rapamycin is an immunosuppressive drug currently used to prevent graft rejection in humans, which is considered permissive for tolerance induction...
  65. ncbi Proteinuria after kidney transplantation, relationship to allograft histology and survival
    H Amer
    Department of Internal Medicine, Division of Nephrology and Hypertension and Transplant Center, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Transplant 7:2748-56. 2007
    ..However, and even low levels of proteinuria relate to poor graft survival. Proteinuria and glomerular pathology relate independently to survival...
  66. doi Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients
    Pål Falck
    Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway
    Transplantation 85:179-84. 2008
    ..We investigated cyclosporine A (CsA) concentrations at the site of action, inside T-lymphocytes, to evaluate its applicability as a new supplementary therapeutic drug monitoring method after renal transplantation...
  67. ncbi T-cell allorecognition and transplant rejection: a summary and update
    Peter S Heeger
    Department of Immunology and The Glickman Urologic Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 3:525-33. 2003
    ....
  68. ncbi T-cell responses during pig-to-primate xenotransplantation
    Eduardo Davila
    Department of Pediatrics, Louisiana State University Health Science Center, Stanley S Scott Cancer Center, New Orleans, LA, USA
    Xenotransplantation 13:31-40. 2006
    ..To determine the potential role of T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46 porcine hearts heterotopically into baboon recipients...
  69. ncbi Factors contributing to acute rejection in renal transplantation: the role of noncompliance
    P E Morrissey
    Division of Organ Transplantation and Medical Statistics, Rhode Island Hospital, Brown Medical School, 593 Eddy Street APC 921, Providence, RI 02903, USA
    Transplant Proc 37:2044-7. 2005
    ..Future strategies to improve compliance, including increased vigilance in high-risk patient groups, frequent medication review, and laboratory testing, should be encouraged...
  70. doi Factors influencing renal function after liver transplantation. Results from the MOST, an international observational study
    P Burra
    Gastroenterology, Department of Surgical and Gastroenterological Sciences, University Hospital Padova, Padova, Italy
    Dig Liver Dis 41:350-6. 2009
    ..Given organ shortage it should be essential to determine which patients will experience progressive and severe renal dysfunction after liver transplantation (LT)...
  71. ncbi Enhancement of antitumor immunity by CTLA-4 blockade
    D R Leach
    Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Science 271:1734-6. 1996
    ..These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells...
  72. ncbi Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d staining
    Enver Akalin
    Renal Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Clin J Am Soc Nephrol 2:1261-7. 2007
    ..We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms...
  73. doi Antibody-mediated rejection in kidney transplantation: an update
    Jessica G Lucas
    Division of Nephrology and Hypertension, Department of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Expert Opin Pharmacother 12:579-92. 2011
    ..Acute antibody-mediated rejection (AMR) in renal-transplant recipients is generally less responsive to conventional antirejection therapy and has a worse prognosis than acute cellular rejection...
  74. pmc Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes
    Grace W Wu
    Division of Cardiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 6988, USA
    J Heart Lung Transplant 28:417-22. 2009
    ..The significance of AMR findings in biopsy specimens of asymptomatic heart transplant patients (normal cardiac function and no symptoms of heart failure) is unclear...
  75. doi Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function
    E C Aquino-Dias
    Post Graduate Medical Sciences Nephrology Program, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Kidney Int 73:877-84. 2008
    ..Our study shows that quantification of selected genes in peripheral blood leukocytes and urinary cells from renal transplant patients with DGF may provide a useful and accurate non-invasive diagnosis of AR...
  76. ncbi Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells
    Yi Ping Jin
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Immunol 65:291-302. 2004
    ..These results suggest that exposure of the graft endothelium to low concentrations of anti-HLA Ab may promote cell survival by transducing signals resulting in upregulation of cell survival genes...
  77. ncbi Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss
    F Moreso
    Nephrology Department, Hospital Universitari de Bellvitge, IDIBELL Institut d Investigacio de Bellvitge, c Feixa Llarga s n, L Hospitalet 08907 Barcelona, Spain
    Am J Transplant 6:747-52. 2006
    ..27, 95% CI: 1.38-3.75; p = 0.01) were independent predictors of graft survival. In protocol biopsies, the detrimental effect of interstitial fibrosis/tubular atrophy on long-term graft survival is modulated by SCR...
  78. ncbi Pediatric heart transplantation in human leukocyte antigen sensitized patients: evolving management and assessment of intermediate-term outcomes in a high-risk population
    Stacey M Pollock-Barziv
    Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children University of Toronto, Toronto, Ontario, Canada
    Circulation 116:I172-8. 2007
    ..We report our experience with human leukocyte antigens-sensitized pediatric HTx recipients...
  79. ncbi Plasmapheresis and cyclophosphamide in the treatment of humoral rejection after heart transplantation
    O Grauhan
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 20:316-21. 2001
    ..Clinical reports on humoral rejection after heart transplantation showed that these episodes were often more severe than those mediated through T lymphocytes and that the patient's prognosis was significantly worsened...
  80. ncbi Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant Study
    Donald T H Tan
    Singapore National Eye Centre, Singapore
    Ophthalmology 115:975-982.e1. 2008
    ..The indications, complications, long-term survival rates, and risk factors for graft failure of penetrating keratoplasty (PK) performed in Asian eyes are reported...
  81. ncbi ABO-incompatible heart transplantation in infants
    L J West
    Department of Paediatrics, Hospital for Sick Children and University of Toronto, ON, Canada
    N Engl J Med 344:793-800. 2001
    ..This contraindication may not apply to newborn infants, who do not yet produce antibodies to T-cell-independent antigens, including the major blood-group antigens...
  82. ncbi Role of immunoproteasomes in cross-presentation
    Michael J Palmowski
    Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
    J Immunol 177:983-90. 2006
    ....
  83. ncbi The changing role of natural killer cells in solid organ rejection and tolerance
    William H Kitchens
    Division of Transplantation, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Transplantation 81:811-7. 2006
    ..These new findings suggest that the role of NK cells in solid organ rejection and tolerance needs to be reexamined...
  84. ncbi Endothelial injury, alarmins, and allograft rejection
    Deepak A Rao
    Department of Immunobiology, Section of Human and Translational Immunology, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    Crit Rev Immunol 28:229-48. 2008
    ....
  85. doi Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejection
    Banu Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Alberta, Canada
    Curr Opin Organ Transplant 15:42-8. 2010
    ..This article reviews recent molecular studies in kidney allograft tissues that decipher molecular burden and mechanisms of ABMR, leading to discovery of a new phenotype: 'C4d-negative ABMR'...
  86. doi Transplant glomerulopathy: risk and prognosis related to anti-human leukocyte antigen class II antibody levels
    Naim Issa
    Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Transplantation 86:681-5. 2008
    ..The goal of this study was to determine the relationships among antibody characteristics (level and specificity), risk for TG, and graft survival...
  87. pmc In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation
    Rutger Jan Swijnenburg
    Department of Cardiothoracic Surgery, Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Stem Cells Dev 17:1023-9. 2008
    ..These data show that mESCs do not retain immune-privileged properties in vivo and are subject to immunological rejection as assessed by novel molecular imaging approaches...
  88. doi Anti-HLA donor-specific antibodies detected in positive B-cell crossmatches by Luminex predict late graft loss
    H S Eng
    Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia
    Am J Transplant 8:2335-42. 2008
    ..Thus, using BXM to preclude kidney transplantation may potentially disadvantage >60% of patients in whom BXM is not indicative of the presence of DSA...
  89. pmc TIM-1 and TIM-3 proteins in immune regulation
    Ee Wern Su
    Department of Immunology, University of Pittsburgh, 200 Lothrop Street, BST E 1056, Pittsburgh, PA 15261, USA
    Cytokine 44:9-13. 2008
    ..We therefore propose that the definition of TIM be adjusted to "transmembrane immunoglobulin and mucin"...
  90. pmc Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Am J Pathol 172:1471-81. 2008
    ....
  91. ncbi Airway epithelium is the primary target of allograft rejection in murine obliterative airway disease
    Felix G Fernandez
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Am J Transplant 4:319-25. 2004
    ..This indicates that the airway epithelium plays a crucial role in OAD development...
  92. doi Abrogation of anti-HLA antibodies via proteasome inhibition
    Hargovind L Trivedi
    Department of Nephrology and Transplantation Medicine, Institute of Kidney Diseases and Research Centre Institute of Transplantation Sciences, Ahmedabad, Gujarat, India
    Transplantation 87:1555-61. 2009
    ..We report the first clinical experience with a plasma cell depleting therapy, bortezomib, to abrogate anti-HLA antibodies in transplantation (outside of rejection) in an attempt to improve long-term allograft survival...
  93. doi Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection
    Matthew J Everly
    Department of Surgery, Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
    Transplantation 86:1754-61. 2008
    ..We report the first clinical experience with plasma cell-targeted therapy (bortezomib) as an antirejection strategy...
  94. ncbi Pathways of allorecognition: implications for transplantation tolerance
    David S Game
    Department of Immunology, Imperial College School of Medicine, London, UK
    Transpl Immunol 10:101-8. 2002
    ..It is hoped that the careful study of these mechanisms will reveal ways of ensuring allorecognition without activation and thus donor-specific tolerance...
  95. ncbi Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine
    B Li
    Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 344:947-54. 2001
    ..CONCLUSIONS: Measurement of mRNA encoding cytotoxic proteins in urinary cells offers a noninvasive means of diagnosing acute rejection of renal allografts...
  96. doi Antibody testing for cardiac antibody-mediated rejection: which panel correlates best with cardiovascular death?
    Monica P Revelo
    George E Wahlen Veterans Affairs Medical Center, Utah Transplantation Affiliated Hospitals, Salt Lake City, Utah, USA
    J Heart Lung Transplant 30:144-50. 2011
    ....
  97. doi A systematic review on steroid withdrawal between 3 and 6 months after kidney transplantation
    Julio Pascual
    Servicio de Nefrologia, Hospital del Mar, Institut Municipal d Asistencia Sanitaria, Universitat Autonoma de Barcelona, Barcelona, Spain
    Transplantation 90:343-9. 2010
    ..Steroid withdrawal (SW) after the first posttransplant months in patients receiving a kidney transplant has been recently discouraged in clinical guidelines...
  98. doi Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant recipients
    Tajinder P Singh
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Heart Lung Transplant 29:517-22. 2010
    ..In this study, we report early clinical outcomes in a cohort of pediatric heart transplant recipients managed using a steroid-avoidance protocol...
  99. doi Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantation
    J M Gloor
    Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Transplant 10:582-9. 2010
    ..With current protocols, very high baseline DSA patients have high rates of AMR and poor long-term allograft survival highlighting the need for improved therapy for these candidates...
  100. pmc Shotgun proteomics identifies proteins specific for acute renal transplant rejection
    Tara K Sigdel
    Department of Pediatrics, Stanford University School of Medicine, CA 94304, USA
    Proteomics Clin Appl 4:32-47. 2010
    ..Acute rejection (AR) remains the primary risk factor for renal transplant outcome; development of non-invasive diagnostic biomarkers for AR is an unmet need...
  101. doi Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: an analysis of the United Network for Organ Sharing database
    Joseph W Rossano
    Department of Pediatrics, Lillie Frank Abercrombie Section of Pediatric Cardiology, Baylor College of Medicine, Texas Children s Hospital, Houston, Tex 77030, USA
    J Thorac Cardiovasc Surg 140:694-9, 699.e1-2. 2010
    ..This study sought to determine the association of elevated anti-human leukocyte antibodies with long-term survival in pediatric heart transplant patients...

Research Grants96

  1. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2000
    ..The knowledge gained from these studies could also be applied to other tissues and organs accessible to ultrasound. ..
  2. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..
  3. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2010
    ..successful nonmyeloablative transplant to treat sickle cell anemia has been limited due to immune-mediated graft rejection. Our research has demonstrated that rapamycin can promote regulatory T cell (Treg) differentiation of naive T ..
  4. Sphingosine 1-phosphate receptors in vascular homeostasis and pathology
    TIMOTHY TUN HLA; Fiscal Year: 2010
    ..These studies are expected to derive critical insights into the workings of S1P receptors, which are important drug targets to control the vascular and immune systems. ..
  5. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2011
    ..Understanding the factors that reverse autoimmunity in the IL-2Rb- deficient model may also provide new information concerning the etiology and potential therapy that may be generally common to several human autoimmune diseases. ..
  6. Transplantation: Alloimmune Networks
    DAVID LINN contact PERKINS; Fiscal Year: 2010
    Our goal is to understand the molecular interactions that regulate the immune response during graft rejection. Multiple studies indicate that graft rejection is complex, polygenic and poorly understood...
  7. T cell regulation by IDO-competent plasmacytoid dendritic cells
    Andrew Mellor; Fiscal Year: 2009
    ..This observation provides a rationale for treating mice with donor allograft and self-antigens to induce tolerance that will protect skin grafts and pancreatic islet cells from T cell mediated destruction. 1 ..
  8. Antiviral Therapy for Polyomavirus Infection
    ARON LUKACHER; Fiscal Year: 2007
    ..g., FDA-approved Gleevec) limit polyomavirus infection, a critical prelude for their potential therapeutic use to prevent polyomavirus reactivation in immunosuppressed individuals. ..
  9. Sustained release calcineurin inhibitors for the prevention of graft rejection
    Thomas Smith; Fiscal Year: 2007
    The long term goal of this research is to reduce toxicity and graft rejection due to dosing problems with the calcineurin inhibitors by developing sustained release subcutaneous injectable formulations for the drugs tacrolimus and ..
  10. NOVEL THERAPIES FOR GRAFT REJECTION IN SENSITIZED HOSTS
    Jerzy Kupiec Weglinski; Fiscal Year: 1999
    ..The functional significance of host humoral reactivity will be probed by testing sera samples in CDC, ADCC, and in passive transfer studies. The effects of sera on the alloreactive T cell functions will be evaluated in MLR. ..
  11. Mechanisms of Acquired Central Transplantation Tolerance
    James Markmann; Fiscal Year: 2003
    ..In sharp contrast, the TS1 line is uniquely suited for the study of graft rejection and transplantation tolerance...
  12. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
  13. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2007
    ..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
  14. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2011
    ..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
  15. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2010
    ..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
  16. Type V Collagen Prevents Lung Allograft Rejection
    David S Wilkes; Fiscal Year: 2010
    ..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
  17. Type V Collagen Prevents Lung Allograft Rejection
    David Wilkes; Fiscal Year: 2009
    ..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
  18. Type V Collagen Prevents Lung Allograft Rejection
    David Wilkes; Fiscal Year: 2007
    ..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
  19. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2010
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. ..
  20. Analysis of T cell epitope repertoire
    Yoram Louzoun; Fiscal Year: 2007
    ..This part of the research will be done in colaboration with an experimental group studying the B and T cell repertoire in autoimmunity. ..
  21. CXCL10/CXCR3 Signaling Regulates TLR4-Mediated Liver Inflamation and Injury
    Yuan Zhai; Fiscal Year: 2010
    ..clinical settings and contributes to patient morbidity/mortality by causing primary liver failure and graft rejection. However, despite extensive research of the disease pathogenesis over the years, no effective therapies are ..
  22. Role of VEGF in Glomerular Endothelial Health & Diseases
    S Karumanchi; Fiscal Year: 2007
    ..abstract_text> ..
  23. Movement of Recipient T-Cells Away From an Allograft
    Mark Poznansky; Fiscal Year: 2003
    ..To date therapeutic control over both acute and chronic graft rejection has been achieved predominantly with immunosuppressive agents targeted against the function of activated ..
  24. Graft Rejection and Accommodation by anti-Gal mAbs
    Anita Chong; Fiscal Year: 2006
    ..We will use this model to investigate the mechanisms by which anti-Gal mAbs elicit graft rejection or induce accommodation...
  25. Role of NF-kB activation in acute allograft rejection
    Maria Luisa Alegre; Fiscal Year: 2010
    ..In this application we propose to investigate the mechanisms by which TCR-CARMA1-NF-?B regulates formation of nTregs, iTregs and Th17 cells and how these effects impact allograft fate. ..
  26. Optimizing Nonmyeloablative Stem Cell Transplantation
    Marco Mielcarek; Fiscal Year: 2007
    ..Most nonablative conditioning regimens contain irradiation, which is thought to be required to prevent graft rejection. However, low doses of irradiation are associated with increased risks of late malignancies, and avoiding ..
  27. Novel Biologic Therapies for BMT: Mechanistic Evaluation in Rhesus Macaques
    Leslie S Kean; Fiscal Year: 2010
    ..Three major complications have plagued the implementation of AD-BMT. They are: (1) The increased risk of graft rejection. (2) The high rate of acute graft-versus-host-disease (aGvHD) that occurs in the setting of MHC-mismatched ..
  28. Role of autoimmunity in transplant rejection
    Gilles Benichou; Fiscal Year: 2007
    ..in heart-transplanted individuals, the CD4 pathway of alloresponse contributes to acute and/or chronic heart graft rejection by triggering autoimmune responses to CM thereby causing cardiac tissue damages in a fashion similar to that ..
  29. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ....
  30. ENGRAFTING SENSITIZED HOSTS WITH NONABLATIVE REGIMENS
    Richard Nash; Fiscal Year: 2002
    ..with blood products become sensitized to donor minor histocompatibility antigens, increasing the risk of graft rejection. Patients with inherited red blood cell diseases require blood transfusions and have a higher probability of ..
  31. ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLY
    Joyce Solheim; Fiscal Year: 2009
    ..abstract_text> ..