graft vs host reaction

Summary

Summary: An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.

Top Publications

  1. ncbi Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR
    Markus Y Mapara
    Transplantation Biology Research Center, Bone Marrow Transplantation Section, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Blood Marrow Transplant 12:623-34. 2006
  2. ncbi Passenger lymphocyte syndrome with severe hemolytic anemia due to an anti-Jk(a) after allogeneic PBPC transplantation
    A Leo
    Institute for Immunology and the Department of Internal Medicine, University Clinics of Heidelberg, Heidelberg, Germany
    Transfusion 40:632-6. 2000
  3. doi Partial HLA matching and RH incompatibility resulting in graft versus host reaction and Evans syndrome after liver transplantation
    Celia Grosskreutz
    Bone Marrow Transplantation Program, Division of Hematology Oncology, Department of Medicine, Mount Sinai Medical Center, New York, New York, USA
    Am J Hematol 83:599-601. 2008
  4. ncbi In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens
    Anne M Dickinson
    University Department of Haematology, Royal Victoria Infirmary, University of Newcastle, Newcastle upon Tyne, UK
    Nat Med 8:410-4. 2002
  5. pmc Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation
    Steven Z Pavletic
    University of Nebraska Medical Center, Omaha, USA
    Blood 106:3308-13. 2005
  6. doi Chimerism studies as an approach for the induction of tolerance to extremity allografts
    Keiichi Muramatsu
    Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Plast Reconstr Aesthet Surg 61:1009-15. 2008
  7. ncbi [Allogeneic adoptive immunotherapy]
    P Tiberghien
    Inserm EPI 0119 Upres EA 2284, Etablissement Français du Sang Bourgogne Franche Comté, Universite de Franche Comte, 1, Boulevard Alexandre Fleming, BP 1937, 25020 cedex, Besancon, France
    Transfus Clin Biol 10:170-4. 2003
  8. ncbi Expression patterns of vascular endothelial growth factor in human cardiac allografts: association with rejection
    Marlies E J Reinders
    Department of Medicine, and Department of Pediatrics Children s Hospital, Boston, Massachusetts 02115, USA
    Transplantation 76:224-30. 2003
  9. ncbi Syngeneic graft-versus-host disease: a report of two cases and literature review
    T Latif
    Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland, OH 44195, USA
    Bone Marrow Transplant 32:535-9. 2003
  10. ncbi Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction
    Masako Murai
    Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Nat Immunol 4:154-60. 2003

Detail Information

Publications137 found, 100 shown here

  1. ncbi Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR
    Markus Y Mapara
    Transplantation Biology Research Center, Bone Marrow Transplantation Section, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Blood Marrow Transplant 12:623-34. 2006
    ....
  2. ncbi Passenger lymphocyte syndrome with severe hemolytic anemia due to an anti-Jk(a) after allogeneic PBPC transplantation
    A Leo
    Institute for Immunology and the Department of Internal Medicine, University Clinics of Heidelberg, Heidelberg, Germany
    Transfusion 40:632-6. 2000
    ..After allogeneic peripheral blood progenitor cell (PBPC) transplantation, a patient developed a severe hemolytic transfusion reaction due to passenger lymphocyte syndrome...
  3. doi Partial HLA matching and RH incompatibility resulting in graft versus host reaction and Evans syndrome after liver transplantation
    Celia Grosskreutz
    Bone Marrow Transplantation Program, Division of Hematology Oncology, Department of Medicine, Mount Sinai Medical Center, New York, New York, USA
    Am J Hematol 83:599-601. 2008
    ..HLA typing was critical in confirming this rare diagnosis and elucidating its cause. Recipients of solid organs from donors that are partially matched in the direction of rejection may need to be closely monitored for GVHD...
  4. ncbi In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens
    Anne M Dickinson
    University Department of Haematology, Royal Victoria Infirmary, University of Newcastle, Newcastle upon Tyne, UK
    Nat Med 8:410-4. 2002
    ..These results provide the first in situ dissection of GvH effects by mHag-specific CTLs and show that ubiquitously expressed mHags are the prime targets of GvH disease...
  5. pmc Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation
    Steven Z Pavletic
    University of Nebraska Medical Center, Omaha, USA
    Blood 106:3308-13. 2005
    ..In spite of a significant reduction of acute GVHD, TCD did not reduce the incidence of cGVHD or improve survival in patients who developed cGVHD...
  6. doi Chimerism studies as an approach for the induction of tolerance to extremity allografts
    Keiichi Muramatsu
    Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Plast Reconstr Aesthet Surg 61:1009-15. 2008
    ..In this review, recent experimental chimerism studies are presented for tolerance induction and we review the prospect of clinical applicability in extremity allograft...
  7. ncbi [Allogeneic adoptive immunotherapy]
    P Tiberghien
    Inserm EPI 0119 Upres EA 2284, Etablissement Français du Sang Bourgogne Franche Comté, Universite de Franche Comte, 1, Boulevard Alexandre Fleming, BP 1937, 25020 cedex, Besancon, France
    Transfus Clin Biol 10:170-4. 2003
    ..Such a transplant modality is now perceived has a very efficient form of adoptive allogeneic immunotherapy unfortunately associated with significant toxicity...
  8. ncbi Expression patterns of vascular endothelial growth factor in human cardiac allografts: association with rejection
    Marlies E J Reinders
    Department of Medicine, and Department of Pediatrics Children s Hospital, Boston, Massachusetts 02115, USA
    Transplantation 76:224-30. 2003
    ..However, little is known of the expression or function of VEGF in acute and chronic allograft rejection...
  9. ncbi Syngeneic graft-versus-host disease: a report of two cases and literature review
    T Latif
    Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland, OH 44195, USA
    Bone Marrow Transplant 32:535-9. 2003
    ..The current report reviews these cases and presents two additional cases of severe SGVHD that have occurred at our institution...
  10. ncbi Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction
    Masako Murai
    Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Nat Immunol 4:154-60. 2003
    ..Mice deficient for PPs failed to develop a-GVHD in two models of disease induction. Thus, blockade of CTL generation in PPs might offer new strategies for circumventing a-GVHD...
  11. doi Correlation of Hsp70-1 and Hsp70-2 gene expression with the degree of graft-versus-host reaction in a rat skin explant model
    Peter Novota
    Department of Cellular and Molecular Immunology, University of Gottingen, Gottingen, Germany
    Transplantation 85:1809-16. 2008
    ..New molecular markers of GVHR might help to further increase the predictive value of the assay...
  12. ncbi Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation
    Gudrun Ratzinger
    Laboratory of Cellular Immunobiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Blood 101:1422-9. 2003
    ..Whether these results support a separation of deleterious from beneficial graft-host interactions at the level of antigen presentation, rather than solely at the level of T cells, will require further evaluation...
  13. ncbi Regulation of alloimmune responses (GvH reactions) in vitro by autologous donor bone marrow cell preparation used in clinical organ transplantation
    James M Mathew
    Department of Surgery, University of Miami School of Medicine, Florida 33136, USA
    Transplantation 74:846-55. 2002
    ..Therefore, we questioned whether an intrinsic immunoregulatory function of (subpopulations of) DBMC might play a role in this observation...
  14. ncbi Interleukin-10 modulation of alloreactivity and graft-versus-host reactions
    Xiao Nong Wang
    Department of Haematology, School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Transplantation 74:772-8. 2002
    ..This study aims to demonstrate, for the first time, whether the addition of exogenous IL-10 can reduce the severity of graft-versus-host reactions (GvHR) in humans...
  15. ncbi Separating graft-versus-tumor from graft-versus-host reactions
    A B T Fassas
    Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Leuk Lymphoma 43:725-33. 2002
    ....
  16. ncbi The role of hematopoietic stem cells in the treatment of ovarian cancer
    A Perillo
    Department of Gynecology and Obstetrics, Catholic University of the Sacred Heart, Rome, Italy
    Panminerva Med 44:197-204. 2002
    ..Perspectives in the use of HSC in oncology comprise the possibility of an HSC ex vivo expansion, the use of umbilical cord blood HSC, and the development of future HSC-based gene-therapy programs...
  17. ncbi Human leucocyte antigen-Cw-specific cytotoxic T lymphocytes generated from naive cord blood used for cord blood stem cell transplantation
    Makoto Yazaki
    Department of Paediatrics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Nagoya 467 8601, Japan
    Br J Haematol 117:893-8. 2002
    ....
  18. ncbi The flavonoid Kaempferol suppresses the graft-versus-host reaction by inhibiting type 1 cytokine production and CD8+ T cell engraftment
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Incorporated, Japan
    Clin Immunol 103:132-44. 2002
    ..Thus, our study indicates that Kaempferol has the capacity to modulate the Th1/Th2 balance and could be useful for the treatment of cell-mediated immune diseases, such as acute GVHD...
  19. doi The thymus in GVHD pathophysiology
    Werner Krenger
    Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland
    Best Pract Res Clin Haematol 21:119-28. 2008
    ..The present review focuses on recent insight into how GVHD affects thymic function and how this knowledge aides the design of new strategies to improve immune reconstitution following allogeneic HSCT...
  20. ncbi Dissociation of putative graft-versus-haematopoiesis and graft-versus-myeloma effects in patients with rapidly progressive multiple myeloma
    Thomas Luft
    Department of Hematology and Rheumatology, University of Heidelberg, Poliklinik and Medizinische Klinik V, Heidelberg, Germany
    Br J Haematol 123:646-53. 2003
    ..Secondly, the graft-versus-myeloma effect that induced CR did not correlate with FDC but was associated with grade III-IV GvHD in our group of heavily pretreated patients...
  21. ncbi Chimerism studies in HLA-identical nonmyeloablative hematopoietic stem cell transplantation point to the donor CD8(+) T-cell count on day + 14 as a predictor of acute graft-versus-host disease
    Søren L Petersen
    Department of Hematology, Rigshospitalet, Copenhagen, Denmark
    Biol Blood Marrow Transplant 10:337-46. 2004
    ..A donor CD8(+) T-cell count above the median on day +14 increased the risk of subsequent development of aGVHD grades II to IV (P =.003)...
  22. ncbi Outcomes of transplantation in children with acute leukaemia
    Vanderson Rocha
    Bone Marrow Transplant Unit and Clinical Research Laboratory on Cell Therapy and Department of Haematology, Hopital Saint Louis, 75010 Paris, France
    Lancet 369:1906-8. 2007
  23. pmc Graft-versus-host disease: a surge of developments
    Stanley R Riddell
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Med 4:e198. 2007
  24. ncbi [Haploidentical 2- or 3-antigen-mismatched hematopoietic stem cell transplantation using in vivo Campath-1H]
    Yoshinobu Kanda
    Rinsho Ketsueki 47:607-17. 2006
  25. pmc An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues
    Ronjon Chakraverty
    Transplantation Biology Research Center, Bone Marrow Transplantation Section, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 203:2021-31. 2006
    ..Our studies help to explain the paradox whereby GVH-reactive T cells can mediate graft-versus-leukemia responses without inducing GVHD in established MCs...
  26. ncbi Single-cell cloning of human, donor-derived antileukemia T-cell lines for in vitro separation of graft-versus-leukemia effect from graft-versus-host reaction
    Daniela Montagna
    Department of Pediatrics, Laboratory of Immunology, University of Pavia, Italy
    Cancer Res 66:7310-6. 2006
    ....
  27. ncbi Therapy of relapsed Hodgkin lymphoma
    Amanda F Cashen
    Division of Oncology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Blood Rev 21:233-43. 2007
    ..New salvage regimens that incorporate gemcitabine, vinorelbine, rituximab, and/or monoclonal antibodies against CD30 are being investigated...
  28. ncbi Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions
    Carol Ann Huff
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, MD 21231, USA
    Biol Blood Marrow Transplant 12:414-21. 2006
    ..However, with the exception of CML, most patients die of their underlying disease because of insufficient antitumor activity even with active GVHD...
  29. ncbi [The experience in non-relative allogenic transplantation of stem hemopoietic cells in the Clinic of Bone Marrow Transplantation at I.P. Pavlov St-Petersburg Medical Academy]
    B V Afanas'iev
    Ter Arkh 79:36-43. 2007
    ..P. Pavlov St-Petersburg Medical Academy for the period 2000-2006...
  30. ncbi Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction
    Katharina Fleischhauer
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 2, 27100 Pavia, Italy
    Blood 107:2984-92. 2006
    ..82; P = .01). These data suggest that in patients with thalassemia, the incidence of graft failure after HSCT may be reduced by appropriate selection of UDs, with such selection taking into account the functional rules of immunogenetics...
  31. ncbi Case of a patient with progressive adult T-cell leukemia/lymphoma treated successfully by reduced-intensity conditioning stem cell transplantation from an HLA-incompatible related donor
    Hiroshi Fujiwara
    Division of Hematology Immunology, Internal Medicine, Kagoshima University Hospital, Japan
    Int J Hematol 82:357-61. 2005
    ..In addition, basiliximab combined with MMF may be effective for the treatment of steroid-refractory skin GVHD without deteriorating the graft-versus-ATL effect...
  32. ncbi Differential sensitivity of T lymphocytes and hematopoietic precursor cells to photochemotherapy with 8-methoxypsoralen and ultraviolet A light
    Mohamed Mabed
    Hematology and Medical Oncology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    Ann Hematol 85:17-24. 2006
    ..Taken together, these data show that ex vivo 8-MOP plus UV-A treatment of the marrow graft cannot be used to prevent post-bone marrow transplantation alloreactivity...
  33. ncbi Levels of anti-A/B antibodies after ABO-incompatible hematopoietic stem cell transplantation
    G Stussi
    Laboratory for Transplantation Immunology, University Hospital of Zurich, Switzerland
    Transplant Proc 37:1385-7. 2005
    ..Thus, there is no evidence for stimulation of donor B lymphocytes to produce antirecipient antibodies suggesting a potential B cell tolerance...
  34. ncbi Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis
    Daisuke Niino
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Pathol Res Pract 200:775-81. 2005
    ..We hypothesize that donor-derived stem cells may play a role in the regeneration of damaged keratinocytes in GVHD...
  35. pmc The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells
    Heather J Symons
    Division of Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 14:499-509. 2008
    ..These events provide the cellular mechanism of the "allogeneic effect" in antitumor immunity. Cy + CD8(-) DLI may be an effective and minimally toxic strategy for awakening the host immune response to advanced cancers...
  36. ncbi Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation
    Jeng Chang Chen
    Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA 94143 0793, USA
    Br J Haematol 126:377-84. 2004
    ..The persistence of donor cells in the peritoneal cavity also correlated with tolerance induction...
  37. ncbi Hematopoietic cell transplantation: progress and obstacles
    M Devetten
    University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198 7680, USA
    Ann Oncol 18:1450-6. 2007
    ..Long-term complications are starting to emerge, and will gain in importance in the near future...
  38. ncbi Non-myeloablative hematopoietic stem cell transplantation
    M Maris
    Fred Hutchinson Cancer Research Center, Seattle, WA, United States
    Transfus Clin Biol 8:231-4. 2001
    ....
  39. ncbi Vascularized lymph node transplantation induces graft-versus-host disease in chimeric hosts
    Cedric G Francois
    Plastic Surgery Research, Department of Surgery, University of Louisville, KY, USA
    Transplantation 81:1435-41. 2006
    ..The purpose of this study was to establish the role of the cellular fraction versus the microenvironment of LNs in the development of GVHD in this model...
  40. pmc Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia
    G R Hill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:459-67. 1999
    ..These data highlight the importance of conditioning in GVHD pathophysiology, and demonstrate that TNF-alpha is critical to GVL mediated by donor T cells, whereas IL-1 is not...
  41. ncbi A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation
    Kimmo Talvensaari
    Laboratoire d Immunologie et d Histocompatibilité, INSERM U 396, Institut Universitaire d Hématologie Service d Hématologie Greffe de Moelle, Hopital Saint Louis, AP HP, Paris, France
    Blood 99:1458-64. 2002
    ..These data indicate an efficient thymic regeneration pathway from CB lymphoid progenitors despite the low number of cells infused compared to bone marrow, arguing for a complete clinical immune recovery after CB transplantation...
  42. ncbi Deficiency in the thymus-dependent immunity in "lethargic" mutant mice
    H C Dung
    Transplantation 23:39-43. 1977
    ..Implications of these results in understanding the immunological status of lethargic mice were considered...
  43. ncbi The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization
    D C Shreffler
    Adv Immunol 20:125-95. 1975
  44. ncbi The use of H-2 mutants as models for the study of T cell activation
    I F McKenzie
    Immunol Rev 35:179-230. 1977
  45. ncbi Response of murine and normal human skin to injection of allogeneic blood-derived psoriatic immunocytes: detection of T cells expressing receptors typically present on natural killer cells, including CD94, CD158, and CD161
    B J Nickoloff
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University of Chicago, Maywood, Ill 60153, USA
    Arch Dermatol 135:546-52. 1999
    ....
  46. ncbi Suppressor function of hepatic mononuclear inflammatory cells during murine chronic graft-vs-host disease. I. Macrophage-enriched cells mediate suppression in the liver
    C D Howell
    University of Colorado School of Medicine, Denver
    Cell Immunol 132:256-68. 1991
    ..T cells contributed to the suppressor activity of both populations. However, the suppressor activity of hepatic MC was mediated largely by a macrophage-enriched population of MC while that of splenic MC was mediated largely by NS cells...
  47. ncbi A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3 neutralizing antibody
    Shan He
    Institute of Health Sciences and Shanghai Institute of Immunology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Immunol 181:7581-92. 2008
    ..Thus, we have established a novel and effective approach with the potential to give rise to new clinical methods for preventing and treating GVHD after allogeneic hematopoietic stem cell transplantation...
  48. ncbi Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade
    Bert Verbinnen
    Division of Clinical Immunology, University Hospital, Catholic University of Leuven, Leuven, Belgium
    J Immunol 181:1034-42. 2008
    ..At later time points (>30 days after splenocyte transfer), clonal deletion of host-reactive T cells was found to be a major mechanism responsible for tolerance...
  49. doi JTA-009, a fully human antibody against human AILIM/ICOS, ameliorates graft-vs-host reaction in SCID mice grafted with human PBMCs
    Nobuyuki Tajima
    Biological and Pharmacological Laboratories Central Pharmaceutical Research Institute, Takatsuki, Japan
    Exp Hematol 36:1514-23. 2008
    ..In the present study, the role of human AILIM/ICOS in T-cell function was investigated using a fully human monoclonal antibody specific to human AILIM/ICOS (JTA-009)...
  50. doi Thrombotic complications after haematopoietic stem cell transplantation: early and late effects
    Dimitrios A Tsakiris
    Department of Haematology, University Hospital Basel, CH 4031 Basel, Switzerland
    Best Pract Res Clin Haematol 22:137-45. 2009
    ..This chapter will discuss the incidence, possible causative associations and treatment options of early and late thrombotic events after haematopoietic stem cell transplantation...
  51. ncbi The impact on the developing embryo and newborn animal of adult homologous cells
    Morten Simonsen
    APMIS 115:510-30; discussion 531-2. 2007
  52. ncbi Total body irradiation-based regimen in the conditioning of patients submitted to haploidentical stem cell transplantation
    C Aristei
    Institute of Radiotherapy Oncology, General Hospital and University, Perugia, Italy
    Radiother Oncol 58:247-9. 2001
    ..25+/-0.09 for acute myeloid leukaemia and 0.17+/-0.07 for acute lymphoid leukaemia patients. CONCLUSIONS: This study shows that the main obstacles limiting the use of mismatched transplants, i.e. GvHD and rejection, were overcome...
  53. doi GVHD pathophysiology: is acute different from chronic?
    Tomomi Toubai
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0942, USA
    Best Pract Res Clin Haematol 21:101-17. 2008
    ..In this chapter we briefly discuss and contrast the pathophysiologies of acute and chronic GVHD...
  54. ncbi Positive and negative selection of T cell repertoires during differentiation in allogeneic bone marrow chimeras
    Kazunori Onoe
    Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Transpl Immunol 12:79-88. 2003
    ..In this communication, the contribution of BM chimera systems to the investigation of the world of T-ology is discussed...
  55. ncbi Graft-versus-host disease after solid organ transplantation: a single center experience and review of literature
    Amit Sharma
    Department of Transplantation Surgery, Virginia Commonwealth University, Richmond, VA 23298, U S A
    Ann Transplant 17:133-9. 2012
    ..We describe our single center experience with three cases of GVHD diagnosed over a period of 15 years in a total of 2,271 solid organ transplant recipients...
  56. ncbi Post-transplantation dynamics of the immune response to chronic myelogenous leukemia
    Rob DeConde
    Stanford Medical Informatics, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Theor Biol 236:39-59. 2005
    ..These observations lead to the hypothesis that anti-host T cells benefit from stimulation by general host blood cells, which induce them to proliferate to sufficient levels to eliminate cancer...
  57. ncbi Establishment of cytolytic T lymphocyte clones to epidermal alloantigen Epa-1
    J D Tyler
    Transplantation 34:140-3. 1982
    ..From these observations, we conclude that the CTLs in each of these long-term lines represent the progeny of a single clone whose specificity is directed toward tissue-specific alloantigens...
  58. doi Consideration of strategies for hematopoietic cell transplantation
    Isaac Yaniv
    Department of Pediatric Hematology Oncology, Schneider Children s Medical Center of Israel, Petach Tikva 49202, Israel
    J Autoimmun 33:255-9. 2009
    ..This proposition refocuses the need to develop strategies of immunomodulation without immunosuppression...
  59. ncbi Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 81:340-8. 2006
    ..These results indicate that increased release of granulysin presents alloreactivity and serum granulysin is useful as a marker of GVHD in SCT...
  60. pmc Comparison of the pharmacological profiles of cyclosporine, (Nva2)-cyclosporine and (Val2)dihydro-cyclosporine
    P C Hiestand
    Immunology 55:249-55. 1985
    ..It does not suppress humoral immunity and allograft rejection, but suppresses some types of cell-mediated immune responses. This derivative may prove useful in autoimmune situations where T cells are involved in the disease process...
  61. ncbi The role of corticotropin-releasing hormone in blastocyst implantation and early fetal immunotolerance
    S N Kalantaridou
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, Greece
    Horm Metab Res 39:474-7. 2007
    ..Defective uterine CRH/CRH-R1 system during early pregnancy may be implicated in the pathophysiology of recurrent miscarriage, placenta accreta, and preeclampsia...
  62. doi Regulatory T cells contribute to the immunoregulatory effect on graft versus host reaction after liver transplantation in donor-dominant one-way MHC matching rats
    Fei Xue
    Department of Hepatobiliary and Pancreatic Surgery, Key Laboratory of Combined Multi organ Transplantation of Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China
    Transpl Immunol 20:232-7. 2009
    ....
  63. pmc Regulation of human immunoglobulin E synthesis in acute graft versus host disease
    J A Saryan
    J Clin Invest 71:556-64. 1983
    ..These results suggest that acute GVHD is accompanied by an imbalance in IgE-specific immunoregulatory T cells consisting of activated helper T cells and deficient suppressor cells...
  64. ncbi Lymphocyte-mediated cytotoxicity
    John H Russell
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Immunol 20:323-70. 2002
    ..host disease, but oversuppression of these pathways may also lead to increased viral susceptibility and/or decreased tumor cell killing...
  65. ncbi Hematopoietic stem cell transplantation in malignant lymphoproliferative diseases. A single center, retrospective study
    A Cucuianu
    Ion Chiricuta Cancer Institute, Dept of Hematology, Bvd 21 Decembrie Nr 73 R 3400 Cluj Napoca, Romania
    Rom J Intern Med 37:227-37. 1999
    ....
  66. ncbi Prolonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage
    Trinh Hermanns-Le
    Department of Dermatopathology, University Medical Center of Liege, Belgium
    Dermatology 206:361-5. 2003
    ..In conclusion, there is great mimicry in the MMD involvement in the dermis during low-grade GVHR and after chronic applications of imiquimod...
  67. ncbi Identification of functional T cell subsets and surface antigen changes during activation as they relate to RT6
    H D Hunt
    Department of Microbiology, University of Iowa, Iowa City
    Cell Immunol 143:194-211. 1992
    ..Following a return to a nonactivated state, the T cells reexpress RT6. The loss and reexpression of RT6 may be related to activation and/or differentiation of T cells...
  68. doi Use of human umbilical cord blood mononuclear cells to prevent perinatal brain injury: a preclinical study
    Jeremie Dalous
    Inserm UMR 676, Universite Paris Diderot, PRES Sorbonne Paris Cité, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    Stem Cells Dev 22:169-79. 2013
    ..We found that the intraperitoneal injection of high amounts of hUCB-MNCs aggravated WMD and was associated with systemic inflammation...
  69. ncbi The allogeneic CD4+ T-cell-mediated graft-versus-leukemia effect
    Y Z Jiang
    Bone Marrow Transplantation Unit, Hematology Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892 1652, USA
    Leuk Lymphoma 28:33-42. 1997
    ..Candidate antigens recognised by CD4+ cells are described and new approaches to GVL modulation in clinical bone marrow transplantation are discussed...
  70. ncbi [Experimental study of optimized H-2 haploidentical hematopoietic engraftment for the treatment of murine acute leukemia model]
    Fan Yi Meng
    Department of Hematology, Nanfang Hospital, the First Military Medical University of PLA, Guangzhou 510515, China
    Zhonghua Xue Ye Xue Za Zhi 24:197-9. 2003
    ..To explore the critical dose of T lymphocyte for preserving graft versus leukemia (GVL) while preventing GVHD in murine acute leukemia model treated with H-2 haploidentical hematopoietic stem cell transplantation (HSCT)...
  71. pmc Antigens shared by malignant plasma cells and normal B cells may be involved in graft versus myeloma
    P A Holloway
    Department of Haematology, UMCU, Utrecht, The Netherlands
    Clin Exp Immunol 131:340-6. 2003
    ..Identification of these proteins will give insight into the relationship between graft versus myeloma (GvM) and GvHD and may provide immunotherapeutical targets in the treatment of MM...
  72. ncbi Regulatory (suppressor) T cells in peripheral allograft tolerance and graft-versus-host reaction
    Gerard Rifle
    UPRES EA563, Faculte de Medecine, Université de Bourgogne and Department of Nephrology Intensive Care Transplantation, Hopital du Bocage, Dijon, France
    Transplantation 77:S5. 2004
    ..The role of this immunomanipulation as one method of inducing tolerance has yet to be clearly defined...
  73. ncbi [A new radiation-free conditioning in bone marrow transplantation and dibromo-mannitol therapy in chronic myeloid leukemia]
    E Kelemen
    Országos Hematológiai és Immunológiai Intézet Budapest
    Orv Hetil 139:2003-1; discussion 2011-2. 1998
    ..The leukemia free post-transplant period was in association with the chronic GVH disease and full chimeric state...
  74. pmc Graft-versus-host reactions in the rat mimic toxin-induced autoimmunity
    H Tournade
    Hospital Broussais, Paris, France
    Clin Exp Immunol 81:334-8. 1990
    ..These findings are in agreement with the prediction that immune dysregulation induced by drugs leads to GVH-like reactions either stimulatory or suppressive depending upon the strain tested...
  75. pmc A simple method for the cryopreservation of lymphocytes. Retention of specific immune effector functions by frozen-stored cells
    C K Grant
    Clin Exp Immunol 23:166-74. 1976
    ..injected murine P815 cells or allogeneic lymphocytes survived freezing; when thawed the cells retained specific immune cytotoxic effector functions including the ability to secrete complement-dependent and leucocyte-dependent antibodies..
  76. ncbi Transient spontaneous engraftment of CD34 hematopoietic cord blood stem cells as seen in peripheral blood: treatment of leprosy patients with anemia by placental umbilical cord whole blood transfusion
    N Bhattacharya
    Bijoygarh State Hospital, Calcutta, India
    Clin Exp Obstet Gynecol 33:159-63. 2006
    ..09%), varying from 3.6% to 16.2%, in 75% of the cases, without provoking any clinical graft vs host reaction in any of the leprosy victims. This value returned to normal within three months in most cases.
  77. ncbi Placental umbilical cord whole blood transfusion to combat anemia in the background of tuberculosis and emaciation and its potential role as an immuno-adjuvant therapy for the under-resourced people of the world
    N Bhattacharya
    Bijoygarh State Hospital, Moore Avenue Specialist Polyclinic and B P Poddar Hospital, New Alipore, Calcutta, India
    Clin Exp Obstet Gynecol 33:99-104. 2006
    ..09%), varying from 2.99% to 33%, which returned to base level in 66.66% at the three-month CD34 re-estimation, without provoking any clinical graft vs host reaction in any of the patients.
  78. ncbi Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens
    Julius A Potian
    Departments of Medicine Hematology Oncology, and Laboratory Medicine, University of Medicine and Dentistry of New Jersey Newark, NJ 07103, USA
    J Immunol 171:3426-34. 2003
    ..The results showed that although MSC elicited allogeneic responses in a model that mimics a graft-vs-host reaction, they also exerted veto-like activity, but caused no effect on responses to recall Ags...
  79. pmc Use of natural killer cells as immunotherapy for leukaemia
    Bartosz Grzywacz
    Division of Blood and Marrow Transplantation, University of Minnesota, MN, USA
    Best Pract Res Clin Haematol 21:467-83. 2008
    ..Future modifications to improve NK cell adoptive immunotherapy by means of increasing target recognition and reducing inhibitory signalling are being explored...
  80. ncbi Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease
    B D Johnson
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226
    Bone Marrow Transplant 11:329-36. 1993
    ..Thus, post-transplant adoptive immunotherapy with normal mononuclear cells from the marrow donor may be an effective way to eliminate residual disease or treat leukemia relapse after BMT without causing significant GVHD...
  81. ncbi Expression of allograft inflammatory factor-1 in inflammatory skin disorders
    Christina Orsmark
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Acta Derm Venereol 87:223-7. 2007
    ..We conclude that AIF-1 may mediate survival and pro-inflammatory properties of macrophages in skin diseases...
  82. ncbi Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Nikki B Marshall
    Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
    J Immunol 181:2382-91. 2008
    ..The generation of CD4(+) cells with regulatory function mediated through activation of the AhR by TCDD may represent a novel pathway for the induction of T-regs...
  83. doi Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction
    Emanuela Marcenaro
    Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, Genova, Italy
    Blood 114:4108-16. 2009
    ....
  84. doi Suppression of cellular immunity by cord blood-derived unrestricted somatic stem cells is cytokine-dependent
    Meike Winter
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Dusseldorf, Germany
    J Cell Mol Med 13:2465-75. 2009
    ..Therapeutically, they may help to protect USSC and possibly their progeny from immune rejection...
  85. doi Immunological behavior of enhanced green fluorescent protein (EGFP) as a minor histocompatibility antigen with a special reference to skin isograft and specific regulation of local graft-versus-host reaction (GvHR)
    Xuan Chao Pan
    Department of Artificial Organ and Transplantation Surgery, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyou ku, Tokyo 113 8655, Japan
    Immunol Lett 123:103-13. 2009
    ....
  86. doi [Native MRT diagnosis of transplantation dysfunction--the acute graft reaction]
    J P Kuhn
    Rofo 180:669-72. 2008
  87. pmc Human embryonic stem cell-derived mesenchymal stromal cell transplantation in a rat hind limb injury model
    Juha P Laurila
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Cytotherapy 11:726-37. 2009
    ..In the present work we studied the distribution of human MSC in a rat hind limb ischemic injury model immediately after transplantation and also analyzed the recipient tissue response to transplanted cells...
  88. doi A pilot study of fat allograft transplantation in immunocompetent rabbits for potential neurosurgical applications
    John S Kuo
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg 114:441-5. 2011
    ..The authors investigated the feasibility of using fat allografts (chemically treated to reduce the host immune response) for neurosurgical applications...
  89. ncbi Graft-versus-host disease
    S Choi
    Blood and Marrow Transplantation Program, Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0942, USA
    Panminerva Med 52:111-24. 2010
    ..In this article we review current and recent advances made in understanding of the cross-talk between these multiple cells and inflammatory molecules that have been implicated in the biology of GVHD...
  90. pmc Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity
    Marieke Griffioen
    Departments of Hematology and Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:3837-42. 2008
    ..We hypothesize that LB-PI4K2B-1S-specific CD4(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8(+) T cell immunity as helper cells...
  91. ncbi Allogeneic memory T cell response
    Benny J Chen
    Division of Cellular Therapy BMT, Duke University Medical Center, Durham, North Carolina, USA
    Biol Blood Marrow Transplant 14:20-2. 2008
    ..A clinical trial has been planned. Successful translation of this approach in the clinic will improve the safety, enhance the effectiveness, and broaden the scope of allogeneic hematopoietic stem cell transplantation...
  92. ncbi Allogeneic peripheral blood stem cell transplantation from related donors mismatched at 2 HLA loci in the host-versus-graft direction
    Toshihiko Ando
    Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan
    Tohoku J Exp Med 214:159-63. 2008
    ..Our experience suggests that PBSC transplantation with an HVG-mismatched related donor and an appropriate conditioning regimen may be a therapeutic option for patients in whom early transplantation is desirable...
  93. doi Clinical applications of adoptive natural killer cell immunotherapy for cancer: current status and future prospects
    Hongfeng Guo
    Department of Hematology, Wuxi People s Hospital, Nanjing Medical University, Wuxi, China
    Onkologie 33:389-95. 2010
    ..Future manipulation to improve NK cell adoptive immunotherapy by means of increasing target recognition and reducing inhibitory signaling is being explored...
  94. doi ABO-incompatible living-donor lobar lung transplantation
    Tsuyoshi Shoji
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Kyoto, Japan
    J Heart Lung Transplant 30:479-80. 2011
    ..To our knowledge, this case represents the first successful living-donor lobar lung transplantation from ABO-incompatible donors...
  95. pmc Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall
    Tamara L Floyd
    Department of Surgery and Emory Transplant Center, Emory University, Atlanta, GA 30322, USA
    J Immunol 186:2033-41. 2011
    ..Thus, these data demonstrate the amount/duration of Ag exposure is a critical factor in determining Tmem's relative requirement for costimulation during the recall response after transplantation...
  96. pmc Acute graft versus host disease
    David A Jacobsohn
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology Transplant, Children s Memorial Hospital, Chicago, IL, USA
    Orphanet J Rare Dis 2:35. 2007
    ..Additional management issues are attention to wound infections in skin GVHD and fluid/nutrition management in gastrointestinal GVHD. About 50% of patients with acute GVHD will eventually have manifestations of chronic GVHD...
  97. pmc Adult thymus transplantation with allogeneic intra-bone marrow-bone marrow transplantation from same donor induces high thymopoiesis, mild graft-versus-host reaction and strong graft-versus-tumour effects
    Takashi Miyake
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Immunology 126:552-64. 2009
    ..Allogeneic IBM-BMT + ATT thus can induce high thymopoiesis, preserving strong GVT effects without severe GVHR...
  98. pmc Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
    Chiara Borsotti
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 110:783-6. 2007
    ..These data suggest that suppressing the secretion of solTNF by donor T cells significantly decreases GVHD without impairing GVT activity...
  99. pmc Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse
    Nadira Durakovic
    Divisions of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Blood 109:4564-74. 2007
    ....
  100. ncbi [Hemolytic anemia caused by graft-versus-host reaction in ABO-nonidentical renal transplants from blood group O donors]
    R Peces
    Servicio de Nefrologia, Hospital Central de Asturias, Oviedo
    Nefrologia 21:395-401. 2001
    ..Follow-up of these patients is warranted for the early detection and optimal management may be achieved by reduction of immunosuppression and change to mycophenolate mofetil...
  101. ncbi Contribution of interleukin-1 to Th1- and Th2-dependent variants of chronic graft-versus-host reaction
    V A Kozlov
    Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk
    Bull Exp Biol Med 132:769-71. 2001
    ..These variants of chronic graft-versus-host reaction are characterized by different changes in interleukin-1 level...

Research Grants76

  1. ORTHOTOPIC LIVER TRANSPLANTATION
    Thomas Starzl; Fiscal Year: 2001
    ..Moreover, the investigators will attempt to develop novel techniques to modify the number and character of the donor cells that ultimately reside in the recipient and promote tolerance to the allograft. ..
  2. MECHANISMS IN SUCCESSFUL THERAPY OF GVHD WITH MOAB
    ROBERT TRUITT; Fiscal Year: 2001
    ..Mechanistic insights gained from the studies, together with the biological principles identified, will facilitate the translational application of MoAb to clinical BMT. ..
  3. MANIPULATION OF GVL/GVH REACTIONS IN ALLOGENEIC BMT
    ROBERT TRUITT; Fiscal Year: 1993
    ..The proposed studies will help identify strategies and reagents that merit further evaluation in clinical BMT as well as those that require modification before use...
  4. CD200 Expression on Apoptotic DCs and Immune Tolerance
    ROBERT TRUITT; Fiscal Year: 2005
    ..These studies will also provide new insight into a novel molecular pathway that is a target for enhancement of antitumor immunity and for prevention of graft rejection. ..
  5. Allospecific Immunoregulatory T Cells in BMT Recipients
    ROBERT TRUITT; Fiscal Year: 2003
    ....
  6. CLONAL GVL/GVH REACTIONS AND ADOPTIVE IMMUNOTHERAPY
    ROBERT TRUITT; Fiscal Year: 1990
    ..The proposed studies are a systematic approach to optimizing the GVL effect while minimizing the GVH effect of cloned CTL. In addition, they will enable us to gain significant new insights into the pathogenesis of clonal GVH reactions...
  7. HEMATOPOIETIC GROWTH FACTORS IN A CANINE STEM CELL MODEL
    Richard Nash; Fiscal Year: 2003
    ....
  8. Strategies for prenatal stem cell transplantation
    Alan W Flake; Fiscal Year: 2010
    ..The ultimate goal of these studies is to develop safe and effective strategies that can be translated to the in utero treatment of a broad range of human genetic hematologic disorders including Sickle Cell Disease and Thalassemia. ..
  9. MODULATING GVH/GVL POST-BMT USING TK EXPRESSING T CELLS
    William Drobyski; Fiscal Year: 2004
    ..The overall goal of this project is to selectively modulate T-cell function and survival in vivo in order to augment the therapeutic index of allogeneic BMT. ..
  10. Nonmyeloablative Hematopoietic Cell Transplantation for Severe Systemic Sclerosis
    Richard Nash; Fiscal Year: 2006
    ..The unique observations in this study regarding responses and recovery of organs after inducing a sustained remission of SSc will serve to focus and direct other non-transplant research activities. ..
  11. Fetal Stromal Progenitor Cells
    Alan Flake; Fiscal Year: 2006
    ..abstract_text> ..
  12. Graft Versus Host Disease and Autoimmunity
    William Drobyski; Fiscal Year: 2007
    ....
  13. Augmentation of GVL Reactivity Without GVHD
    William Drobyski; Fiscal Year: 2007
    ..Better understanding of how to reduce this complication while at the same time preserving the beneficial effects that result from the transplant will lead to new therapies and better outcomes for patients. ..
  14. Graft Versus Host Disease and Autoimmunity
    William Drobyski; Fiscal Year: 2009
    ....
  15. Fetal Biology and Therapy Training Program
    Alan Flake; Fiscal Year: 2007
    ..Penn Graduate School and IHGT. This request is made for 2 Trainee slots in year 1, 3 Trainee slots in year 2, and 4 Trainee slots each year thereafter. ..
  16. Lung Transplantation and Immune Tolerance in Young Recipients
    Richard Nash; Fiscal Year: 2007
    ..Development of preclinical strategies for the induction of lung-specific tolerance in large animal models to prevent acute and chronic rejection will increase the probability of successful translation to human studies. ..
  17. Protection from GVHD with Gene-Modified Donor T Cells
    Richard Nash; Fiscal Year: 2007
    ....
  18. ENGRAFTING SENSITIZED HOSTS WITH NONABLATIVE REGIMENS
    Richard Nash; Fiscal Year: 2002
    ..By lessening the morbidity and mortality associated with conventional conditioning, these studies could significantly change the management of selected inherited red blood cell diseases. ..
  19. PRENATAL STRATEGIES FOR TREATMENT OF HEMOGLOBINOPATHIES
    Alan Flake; Fiscal Year: 2002
    ..abstract_text> ..
  20. GENE MODIFIED CLONED PIGS
    Thomas Starzl; Fiscal Year: 2003
    ..abstract_text> ..
  21. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
    ....
  22. Strategies for Prenatal Stem Cell Tranplantation
    Alan Flake; Fiscal Year: 2004
    ..The studies in this proposal are designed to identify and test strategies to increase engraftment after IUHSCTx. This would allow application of this approach to a broad range of prenatally diagnosed genetic disorders. ..
  23. Augmentation of GVL Reactivity Without GVHD
    William Drobyski; Fiscal Year: 2009
    ..Better understanding of how to reduce this complication while at the same time preserving the beneficial effects that result from the transplant will lead to new therapies and better outcomes for patients. ..
  24. Strategies for prenatal stem cell transplantation
    Alan Flake; Fiscal Year: 2007
    ..The ultimate goal of these studies is to develop safe and effective strategies that can be translated to the in utero treatment of a broad range of human genetic hematologic disorders including Sickle Cell Disease and Thalassemia. ..
  25. Translational Research in Multiple Myeloma
    CAROL HUFF; Fiscal Year: 2006
    ..abstract_text> ..