cellular immunity

Summary

Summary: Those manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.

Top Publications

  1. ncbi The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 226:191-204. 2008
  2. pmc Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
    Michael Walther
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS Pathog 5:e1000364. 2009
  3. pmc Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape
    Robert L Ferris
    The Hillman Cancer Center Research Pavilion, 5117 Centre Ave, Room 2 26b, Pittsburgh, PA 15213, USA
    J Clin Oncol 28:4390-9. 2010
  4. ncbi Understanding the contribution of cellular immunity to dengue disease pathogenesis
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 225:300-13. 2008
  5. pmc Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania
    Nicolas Collin
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000441. 2009
  6. ncbi Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
  7. pmc Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection
    Roland R Regoes
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Virol 78:4866-75. 2004
  8. ncbi Vaccines against intracellular infections requiring cellular immunity
    R A Seder
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 406:793-8. 2000
  9. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
  10. pmc Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
    Zijiang Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 4:458-69. 2008

Detail Information

Publications258 found, 100 shown here

  1. ncbi The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 226:191-204. 2008
    ..Finally, IL-27 limits protective immunity in the lung, but it is also required for long-term survival. These cytokines are therefore key players in the immune response to TB...
  2. pmc Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
    Michael Walther
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS Pathog 5:e1000364. 2009
    ..These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation...
  3. pmc Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape
    Robert L Ferris
    The Hillman Cancer Center Research Pavilion, 5117 Centre Ave, Room 2 26b, Pittsburgh, PA 15213, USA
    J Clin Oncol 28:4390-9. 2010
    ..However, these results are only seen in a subset (20% to 30%) of patients. We discuss the immunologic mechanism(s) underlying these clinical findings and their potential role in the variability in patients' clinical response...
  4. ncbi Understanding the contribution of cellular immunity to dengue disease pathogenesis
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 225:300-13. 2008
    ....
  5. pmc Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania
    Nicolas Collin
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000441. 2009
    ..This protection was associated with the development of cellular immunity in the form of a delayed-type hypersensitivity response and the presence of IFN-gamma at the site of sand ..
  6. ncbi Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
    ..This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer...
  7. pmc Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection
    Roland R Regoes
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Virol 78:4866-75. 2004
    ..acute human immunodeficiency virus infection is controlled by target cell limitation or by virus-specific cellular immunity. To resolve this question, we developed a novel mathematical modeling scheme which allows us to incorporate ..
  8. ncbi Vaccines against intracellular infections requiring cellular immunity
    R A Seder
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 406:793-8. 2000
    ..We then discuss current approaches for vaccination against diseases in which cellular immune responses are important for protection...
  9. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
    ..It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors...
  10. pmc Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
    Zijiang Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 4:458-69. 2008
    ..gondii. This work shows that Atg5 expression in phagocytic cells is essential for cellular immunity to intracellular pathogens in vivo, and that an autophagy protein can participate in immunity and ..
  11. pmc Augmentation of cellular immunity and reduction of influenza virus titer in aged mice fed Lactobacillus casei strain Shirota
    Tetsuji Hori
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186 8650, Japan
    Clin Diagn Lab Immunol 9:105-8. 2002
    ..6) and 10(2.2 +/- 0.5), respectively). These findings suggest that oral administration of L.casei strain Shirota activates not only systemic cellular immunity but also local cellular immunity and that it ameliorates IFV infection.
  12. pmc Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity
    Matthew P Morrow
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 113:5868-77. 2009
    ..Lastly, we report that IL-28B can induce 100% protection from mortality after a lethal influenza challenge. These data suggest that IL-28B is a strong candidate for further studies of vaccine or immunotherapy protocols...
  13. ncbi Immunology of tuberculosis
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Immunol 19:93-129. 2001
    ..The pace of this research must be maintained if we are to realize an effective vaccine in the next decades...
  14. pmc High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon
    Pierre Becquart
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 5:e9126. 2010
    ..show that a large fraction of the human population living in forested areas of Gabon has both humoral and cellular immunity to ZEBOV...
  15. ncbi Drosophila hemopoiesis and cellular immunity
    Michael J Williams
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, Sweden
    J Immunol 178:4711-6. 2007
    ..In this review, I will discuss what is currently known about Drosophila hemopoiesis and the cellular immune response and where possible compare it to vertebrate mechanisms...
  16. ncbi TLR2-, TLR4- and Myd88-independent acquired humoral and cellular immunity against Salmonella enterica serovar Typhimurium
    Sabine A Seibert
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, D 10117 Berlin, Germany
    Immunol Lett 127:126-34. 2010
    ..Our results demonstrate that in the ST infection model, MyD88 as well as TLR2 and TLR4 were largely dispensable for the induction of protective acquired immunity...
  17. pmc Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, Rochester, MN 55905, USA
    Hum Genet 127:207-21. 2010
    ..This is the first paper to present evidence that polymorphisms in the TLR, vitamin A, vitamin D receptor, and innate immunity genes can influence adaptive cytokine responses to rubella vaccination...
  18. pmc Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
    A Gallimore
    Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 187:1647-57. 1998
    ..This report, therefore, indicates that immunodominant epitopes should be defined, not only by the strength of the CTL response that they stimulate, but also by the ability of the CTLs to protect against infection...
  19. ncbi Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Immunol 178:2979-86. 2007
    ..These results suggest that Ag-carrying gamma-PGA NPs are capable of inducing strong cellular and humoral immune responses and might be potentially useful as effective vaccine adjuvants for the therapy of infectious diseases...
  20. doi Vaccines: correlates of vaccine-induced immunity
    Stanley A Plotkin
    Sanofi Pasteur, Doylestown, Pennsylvania, USA
    Clin Infect Dis 47:401-9. 2008
    ..In situations where the true correlate of protection is unknown or difficult to measure, surrogate tests (usually antibody measurements) must suffice as predictors of protection by vaccines. Examples of each circumstance are given...
  21. doi Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis
    Roland Klingenberg
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 30:946-52. 2010
    ..The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response...
  22. ncbi Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone
    Jeffrey Pudney
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 73:1253-63. 2005
    ....
  23. ncbi Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo
    B Palermo
    Experimental Immunology, IRCCS Maugeri Foundation, Pavia, Italy
    J Invest Dermatol 117:326-32. 2001
    ..These findings strongly suggest a role for cellular immunity in the pathogenesis of vitiligo and impact on the common mechanisms of self tolerance.
  24. ncbi Neuronal plasticity and cellular immunity: shared molecular mechanisms
    L M Boulanger
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Neurobiol 11:568-78. 2001
    ..Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems...
  25. ncbi Viral immune evasion: a masterpiece of evolution
    Mireille T M Vossen
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Immunogenetics 54:527-42. 2002
    ..This review aims at summarizing the current knowledge of viral evasion mechanisms...
  26. ncbi Bacterial immunity traded for sperm viability in male crickets
    Leigh W Simmons
    Evolutionary Biology Research Group, School of Animal Biology M092, University of Western Australia, Crawley, WA 6009, Australia
    Science 309:2031. 2005
    ..These data have implications for our understanding of sexual selection mechanisms and of reproductive costs in male longevity...
  27. pmc Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
    Marcin Kwissa
    Vaccine Research Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Exp Med 204:2733-46. 2007
    ..Viral loads were inversely correlated with the magnitude and quality of the immune response. Thus, the immunogenicity of DNA vaccines can be augmented with TLR9-L plus FL...
  28. pmc Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
    Nicole Schmitz
    Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    J Virol 79:6441-8. 2005
    ..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
  29. pmc Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity
    Brian M Janelsins
    Department of Dermatology, University of Pittsburgh School of Medicine, PA, USA
    Blood 113:3017-26. 2009
    ..with Ag exhibit increased longevity in draining lymph nodes, resulting in enhanced and prolonged effector cellular immunity. Our results contribute to the understanding of the interactions between the immune and nervous systems that ..
  30. pmc The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity
    Christopher V Nicchitta
    Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC 27710, USA
    Cell Stress Chaperones 9:325-31. 2004
    ..Recent insights into the pathways for peptide generation now allow this hypothesis to be critically examined, which is the subject of this review...
  31. pmc Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease
    Jolanda D F de Groot-Mijnes
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    J Virol 79:1036-44. 2005
    ..Experimental FIP presents a relevant, safe, and well-defined model to study coronavirus-mediated immunosuppression and should provide an attractive and convenient system for in vivo testing of anticoronaviral drugs...
  32. ncbi Innate and adaptive cellular immunity in flavivirus-naïve human recipients of a live-attenuated dengue serotype 3 vaccine produced in Vero cells (VDV3)
    Violette Sanchez
    Sanofi Pasteur, Research and Development Department, Marcy l Etoile, France
    Vaccine 24:4914-26. 2006
    ..Lessons learned from these results will help us to pursue the development of safe and immunogenic vaccines...
  33. pmc Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine
    Catherine A Cosgrove
    CMM Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    Infect Immun 74:2449-52. 2006
    ..Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines...
  34. pmc Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies
    John R Mascola
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:10348-56. 2003
    ..To assess if HIV-1/SIV-specific cellular immunity could combine with antibodies to produce sterile protection, we studied the effect of a suboptimal infusion ..
  35. ncbi Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity
    Ikuo Imazeki
    Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapparo, Japan
    Biomed Res 27:1-9. 2006
    ..Thus, VitD3 derivatives are demonstrated to inhibit the functional differentiation of DC1, Tc1 and Th1 cells, which play a critical role in type-1 cellular immune responses...
  36. pmc In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles
    Young Jik Kwon
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:18264-8. 2005
    ..In particular, activating sufficient cytotoxic T lymphocyte-mediated cellular immunity, which is crucial for the treatment of many diseases including cancer and AIDS, has proven to be especially ..
  37. ncbi Overview of the cellular immunity against JC virus in progressive multifocal leukoencephalopathy
    Igor J Koralnik
    Department of Neurology and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurovirol 8:59-65. 2002
    ..02). This cellular immune response may therefore be crucial in the prevention of PML disease progression and the tetramer staining assay may be used as a prognostic marker in the clinical management of these patients...
  38. ncbi The net immunologic advantage of laparoscopic surgery
    Y W Novitsky
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA, USA
    Surg Endosc 18:1411-9. 2004
    ..Comparative studies of cellular immunity after laparoscopic and conventional surgery demonstrate immunologic advantage conferred by laparoscopy...
  39. pmc Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organs
    Rebecca V Anderson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S, 4th Street, Hamilton, MT 59840, USA
    Vaccine 28:6562-72. 2010
    ..tularensis infection. Instead, survival of SchuS4 infection at extended time points after immunization was only associated with production of IFN-γ and activation of T cells in peripheral organs...
  40. pmc Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5547. 2009
    ..Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans and non-human primates...
  41. pmc Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity
    Elizabeth S Gabitzsch
    Etubics Corporation, Seattle, WA 98104, United States
    Vaccine 27:6394-8. 2009
    ..We are evaluating this recombinant triad viral vector as an HIV-1 vaccine in a non-human primate model and the data indicate that the vaccine is worthy of clinical evaluation...
  42. ncbi Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis
    K Ayada
    Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Lupus 18:1154-68. 2009
    ..pylori accelerates atherosclerosis in mice and the active immunisation with Hp-HSP60 or the eradication of H. pylori with antibiotics can moderate/prevent cellular immunity, resulting in a reduction of atherosclerosis.
  43. ncbi The immune system in the elderly: II. Specific cellular immunity
    L Ginaldi
    Department of Internal Medicine and Public Health, University of L Aquila, Italy
    Immunol Res 20:109-15. 1999
    ..The present review analyzes the main changes of the T cell compartment characterizing immunosenescence and discusses the possible mechanisms underlying these disregulations and their clinical implications...
  44. ncbi Suppression of cellular immunity in men with a past history of posttraumatic stress disorder
    N Kawamura
    Department of Psychosomatic Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan
    Am J Psychiatry 158:484-6. 2001
    ..CONCLUSIONS: PTSD leaves a long-lasting immunosuppression and has long-term implications for health...
  45. pmc Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus
    Bhawna Poonia
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 114:1196-204. 2009
    ..Anti-FasL treatment during the initial stages of acute SIV infection preserved the T-cell compartment and sustained cell-mediated immunity to SIV...
  46. ncbi Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation
    Fusheng Li
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Vaccine 24:6893-904. 2006
    ..The usability of PTE peptide set was manifested by detection of Nef-specific CTL responses in HIV-1 subtype B infections...
  47. ncbi Effects of cryopreservation on lymphocyte immunophenotype and function
    A Costantini
    Service of Clinical Immunology, Department of Internal Medicine, Ancona University Medical School, Ancona, Italy
    J Immunol Methods 278:145-55. 2003
    ..e. studies of immune reconstitution following antiretroviral therapy in HIV-infected patients or studies of HIV-infectivity in vitro using CCR5-tropic strains) should be performed on fresh samples...
  48. ncbi Recombinant viruses as tools to induce protective cellular immunity against infectious diseases
    Carolina Damas Rocha
    Laboratory of Immunopathology, René Rachou Research Center, Oswaldo Cruz Foundation FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
    Int Microbiol 7:83-94. 2004
    ..when purified subunit vaccines are administered using traditional immunization protocols, the levels of cellular immunity induced are mostly low and not capable of eliciting complete protection against diseases caused by ..
  49. ncbi HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection
    Marco Mirani
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:6361-8. 2002
    ..can be explained by glucocorticoid-induced inhibition of cytokine networks regulating innate and Th1-driven cellular immunity. We demonstrated that extracellularly administered Vpr protein dose-dependently potentiated glucocorticoid-..
  50. ncbi Psychological interventions and the immune system: a meta-analytic review and critique
    G E Miller
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Health Psychol 20:47-63. 2001
    ..This literature has important conceptual and methodological issues that need to be resolved before any definitive conclusions can be reached...
  51. ncbi Induction of MUC1-specific cellular immunity by a recombinant BCG expressing human MUC1 and secreting IL2
    Jianbo He
    Revlon UCLA Breast Center, Department of Surgery, University of California at Los Angeles, School of Medicine, 90095, USA
    Int J Oncol 20:1305-11. 2002
    ..These results suggest that BCG-MUC1-IL2 preferentially induces MUC1-specific cellular immune responses and it may serve as a vaccine for breast cancer prevention and treatment...
  52. ncbi High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection
    Georg M Lauer
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 127:924-36. 2004
    ..Previous studies have largely focused on limited HLA alleles and predefined CD8+ T-cell epitopes, and, thus, comprehensive studies remain to be performed...
  53. pmc Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle
    Rick A Bright
    Novavax, Inc, Rockville, Maryland, USA
    PLoS ONE 3:e1501. 2008
    ....
  54. pmc Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection
    Annette Oxenius
    Nuffield Department of Medicine, John Radcliffe Hospital and Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK
    Proc Natl Acad Sci U S A 99:13747-52. 2002
    ..Overall, these data indicate that STI-induced quantitative boosting of HIV-specific cellular immunity was not associated with substantial change in viral replication and that STI was largely restoring ..
  55. pmc Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity
    SangKon Oh
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:3392-7. 2003
    ....
  56. ncbi TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells
    Sarah C Higgins
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Immunol 177:7980-9. 2006
    ..Our findings also demonstrate that activation of innate immune cells through TLR4 helps to direct the induction of Th1 and Th-17 cells, which mediate protective cellular immunity to B. pertussis.
  57. pmc HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
    Christine M Rousseau
    Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 82:6434-46. 2008
    ....
  58. ncbi Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection
    Mark R Schleiss
    Department of Pediatrics, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN, 55455, USA
    J Infect Dis 195:789-98. 2007
    ..These results indicate that cell-mediated immune responses directed against a CMV matrix protein can protect against congenital CMV infection and disease...
  59. doi The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity
    Ying Liu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    Biomaterials 30:3934-45. 2009
    ..The underlying mechanism for high anticancer activity may be attributed to the fact that this water-soluble nanomaterial effectively triggers the host immune system to scavenge tumor cells...
  60. pmc Delivery of human immunodeficiency virus vaccine vectors to the intestine induces enhanced mucosal cellular immunity
    Lingshu Wang
    Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD 20892 3005, USA
    J Virol 83:7166-75. 2009
    ..These studies suggest that induction of primary immune responses by rAd5 gut immunization and subsequent systemic boosting elicits potent antigen-specific gut mucosal responses...
  61. ncbi Pediatric autoimmune liver diseases: the molecular basis of humoral and cellular immunity
    L Wen
    Section of Endocrinology, Department of Medicine, Yale University, New Haven, CT 06520, USA
    Curr Mol Med 1:379-89. 2001
    ..The presence of cross-reactivity between homologous sequences, especially between HCV and cytochromes, supports the possibility that molecular mimicry plays a role in the induction of autoantibodies and autoreactive cytotoxic T cells...
  62. ncbi Vaccination with replication-deficient recombinant adenoviruses encoding the main surface antigens of toxoplasma gondii induces immune response and protection against infection in mice
    Bráulia C Caetano
    Laboratorio de Imunoparasitologia, Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270 901, Brazil
    Hum Gene Ther 17:415-26. 2006
    ..gondii antigens, other parasite antigens should be tested alone or in combination with those described here to further develop a protective vaccine against toxoplasmosis...
  63. ncbi Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
    L D Shultz
    Jackson Laboratory, Bar Harbor, ME 04609
    J Immunol 154:180-91. 1995
    ..B-17/Sz-scid/scid animals. The multiple defects in innate and adaptive immunity unique to the NOD/LtSz-scid/scid mouse provide an excellent in vivo environment for reconstitution with human hematopoietic cells...
  64. ncbi Better influenza vaccines for older people: what will it take?
    Janet E McElhaney
    J Infect Dis 198:632-4. 2008
  65. ncbi Alcohol, injury, and cellular immunity
    Kelly A Nordyke Messingham
    Department of Cell Biology, Loyola University Chicago, Maywood, IL 60153, USA
    Alcohol 28:137-49. 2002
    ..Independently, alcohol exposure and injury have been shown to influence cellular immunity negatively...
  66. pmc Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Exp Med 202:761-9. 2005
    ..pneumoniae, the former of which is required for IFN-gamma expression and the latter of which is required for IL-17 production...
  67. pmc AHR-mediated immunomodulation: the role of altered gene transcription
    Nancy I Kerkvliet
    Department of Environmental and Molecular Toxicology and Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA
    Biochem Pharmacol 77:746-60. 2009
    ..Based on studies using AHR(-/-) mice, evidence for a role of endogenous AHR ligands in regulation of the immune response is growing, with bilirubin and lipoxinA4 representing two promising candidates...
  68. pmc Protective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8(+) T cells expressing gamma interferon
    Sang Heui Seo
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Virol 76:4886-90. 2002
    ..Our findings indicate that pulmonary cellular immunity may be very important in protecting naïve natural hosts against lethal influenza viruses.
  69. ncbi Cellular immunity and active human cytomegalovirus infection in patients with septic shock
    Lutz von Muller
    Institute of Virology, University Hospital Ulm, Ulm, Germany
    J Infect Dis 196:1288-95. 2007
    ....
  70. ncbi Induction of cellular immunity against hair follicle melanocyte causes alopecia
    Hiroshi Nagai
    Department of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Arch Dermatol Res 298:131-4. 2006
    ..Although hair follicle melanocytes have long been thought to be one of the targets of AA, evidence to support the hypothesis is sparse. Therefore, we believe that our observation is significant to support the hypothesis...
  71. pmc Developing DNA vaccines that call to dendritic cells
    Michele A Kutzler
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 114:1241-4. 2004
    ..Such cooperative strategies delivering vaccine in a single, simple platform result in improved cellular immunity in vivo, including enhanced tetramer responses and IFN-gamma secretion by antigen-specific cells.
  72. ncbi Cellular immunity and levels of parathyroid hormone in uremic patients receiving hemodialysis
    Ioannis Griveas
    Nephrology Department, Papageorgiou General Hospital, Thessaloniki, Greece
    Ren Fail 27:275-8. 2005
    ..We studied the changes in cellular immunity in patients in hemodialysis (HD) therapy and examined the relationship between T-lymphocyte function and ..
  73. pmc Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: An exploratory study
    Bonnie B Blomberg
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA
    J Psychosom Res 67:369-76. 2009
    ....
  74. pmc Dopamine beta-hydroxylase deficiency impairs cellular immunity
    R C Alaniz
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:2274-8. 1999
    ..These results indicate that physiological catecholamine production is not required for normal development of the immune system, but plays an important role in the modulation of T cell-mediated immunity to infection and immunization...
  75. ncbi The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats
    E Skopńska-Rózewska
    Department of Pathology, Biostructure Center, Medical University, Warsaw, Poland
    Pol J Vet Sci 11:105-11. 2008
    ..to study the in vivo effect of aqueous and 50% hydro-alcoholic extracts of Rq rhizomes on some parameters of cellular immunity in mice and rats...
  76. ncbi CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity
    Heth R Turnquist
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int J Oncol 30:631-9. 2007
    ....
  77. ncbi Mechanisms of central nervous system viral persistence: the critical role of antibody and B cells
    Chandran Ramakrishna
    Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    J Immunol 168:1204-11. 2002
    Contributions of humoral and cellular immunity in controlling neurotropic mouse hepatitis virus persistence within the CNS were determined in B cell-deficient J(H)D and syngeneic H-2(d) B cell+ Ab-deficient mice...
  78. pmc The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:1607-18. 2004
    ....
  79. pmc Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    Birgit Knoechel
    Department of Pathology, University of California, San Francisco, School of Medicine, CA 94143, USA
    J Exp Med 202:1375-86. 2005
    ..Thus, a peripheral T cell reaction to a systemic antigen goes through a phase of effector cell-mediated pathology followed by T reg cell-mediated recovery, and both require the growth factor IL-2...
  80. ncbi Cord blood leucocyte expression of functionally significant molecules involved in the regulation of cellular immunity
    S Hodge
    Haematology Department, Women s and Children s Hospital, 72 King William Street, Adelaide, South Australia
    Scand J Immunol 53:72-8. 2001
    ..The findings of lower expression of IL-2R beta and lower production of inflammatory cytokines IL-1 alpha, IL-1 beta and TNF-alpha is a basis for improved understanding of the immunological immaturity of leucocytes in the newborn...
  81. ncbi Molecular regulation of cellular immunity by FOXP3
    Alicia N McMurchy
    Department of Surgery, University of British Columbia, Vancouver, Canada
    Adv Exp Med Biol 665:30-46. 2009
    ....
  82. ncbi Recombinant attenuated Salmonella harboring 4-1BB ligand gene enhances cellular immunity
    Jian Xin Ye
    Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Key Laboratory of Clinical Immunology of Jiangsu Province, Suzhou 215006, China
    Vaccine 27:1717-23. 2009
    ..To transfect antigen presenting cells (APCs) with 4-1BB ligand DNA by attenuated Salmonella enterica serovar Typhimurium in vivo, and to observe the effects of ectogenous 4-1BBL on the immune functions of infected rats...
  83. pmc Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant
    Anna U Bielinska
    University of Michigan Nanotechnology Institute for Medicine and Biological Sciences and Department of Internal Medicine, Ann Arbor, Michigan 48109 5648, USA
    Crit Rev Immunol 30:189-99. 2010
    ..We have developed a novel mucosal nanoemulsion (NE) adjuvant that produces a robust humoral and T1 cellular immunity. Herein, we demonstrate that immunization with NE adjuvant induces a T17 response to diverse antigens in ..
  84. ncbi Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    Helen McShane
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Nat Med 10:1240-4. 2004
    ..Boosting vaccinations with MVA85A could offer a practical and efficient strategy for enhancing and prolonging antimycobacterial immunity in tuberculosis-endemic areas...
  85. ncbi A synthetic HIV-1 Tat protein breaches the skin barrier and elicits Tat-neutralizing antibodies and cellular immunity
    Charalambos D Partidos
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
    Eur J Immunol 34:3723-31. 2004
    ..Transcutaneous immunization may be advantageous for the non-invasive delivery of other HIV candidate vaccine antigens...
  86. pmc Multigene DNA priming-boosting vaccines protect macaques from acute CD4+-T-cell depletion after simian-human immunodeficiency virus SHIV89.6P mucosal challenge
    N A Doria-Rose
    Seattle Biomedical Research Institute, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:11563-77. 2003
    ..b>Cellular immunity to SHIV89...
  87. pmc Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen
    Jess H Leber
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS Pathog 4:e6. 2008
    ..Combinatorial control of IFNbeta induction by recognition of both DNA and MDP may highlight a mechanism by which the innate immune system integrates the responses to multiple ligands presented in the cytosol by intracellular pathogens...
  88. ncbi Human immunodeficiency virus-type 1 specific cellular immunity in chronic infected patients on prolonged highly active antiretroviral treatment and on structured treatment interruption
    Reikei Matsuda
    Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Novelsvägen, Solna, Sweden
    Microbiol Immunol 50:629-35. 2006
    ..We analyzed Nef, Tat, and p24 specific cellular immunity using IFN-gamma enzyme-linked immunospot assays and T cell proliferation assays...
  89. ncbi Severe feed restriction enhances innate immunity but suppresses cellular immunity in chicken lines divergently selected for antibody responses
    B N Hangalapura
    Adaptation Physiology Group, Wageningen Institute of Animal Sciences, Wageningen University, Wageningen, The Netherlands
    Poult Sci 84:1520-9. 2005
    ..Finally, under severe FR, relative spleen weight was lower in the L line than in the H line. The present findings suggest genetic differences affecting physiological and immunological responses under FR conditions...
  90. ncbi The discovery of cellular immunity in the atherosclerotic plaque
    Goran K Hansson
    Karolinska Institutet, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 29:1714-7. 2009
    ..This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept...
  91. ncbi DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity
    Masaru Shimada
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vaccine 28:4920-7. 2010
    ..These results demonstrate that covalent antigen modification with an Ig sequence can modulate antigen-specific cellular immune responses. The approach may be useful for vaccine development...
  92. ncbi Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 17:625-34. 2006
    ..Adoptive transfer experiments demonstrated that AAT gene therapy attenuated cellular immunity associated with beta cell destruction...
  93. pmc Cellular immunity in children with successful immunoprophylactic treatment for mother-to-child transmission of hepatitis B virus
    Haruki Komatsu
    Department of Pediatrics, Yokohama Eastern Hospital, 3 6 1 Shimosueyoshi Tsurumi Yokohama, Kanagawa 230 0012, Japan
    BMC Infect Dis 10:103. 2010
    ..However, little is known about immunity against HBV infection in children after immunoprophylactic treatment. We tried to assess the association between T-cell responses and viremia in children after successful prophylactic treatment...
  94. ncbi Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine
    B C Gilger
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210 1089, USA
    Vet Immunol Immunopathol 49:199-208. 1995
    Peripheral cellular immunity of ten dogs with keratoconjunctivitis sicca (KCS) that had not been treated with topical corticosteroids or cyclosporine was evaluated (by use of in vitro lymphocyte proliferation assays and CD4+/CD8+ ..
  95. ncbi Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    Med Mycol 43:381-9. 2005
    ..More importantly, the studies summarized herein demonstrate that understanding the host response to a protein or mutant fungus is critical to creating a vaccine that may be useful for the immunocompromised patient...
  96. ncbi Cellular immunity to varicella-zoster virus in patients with major depression
    M Irwin
    VA Medical Center, University of California, San Diego, USA
    J Infect Dis 178:S104-8. 1998
    ..and this appears to be causally related to an age-dependent decline in varicella-zoster virus (VZV)-specific cellular immunity. Psychologic stress has also been linked to the occurrence of herpes zoster, but the mechanism involved has ..
  97. ncbi Impact of aging on innate immunity
    G Pawelec
    Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    J Leukoc Biol 64:703-12. 1998
    ....
  98. ncbi Recombinant vaccinia virus expressing interleukin-2 invokes anti-tumor cellular immunity in an orthotopic murine model of head and neck squamous cell carcinoma
    Santanu Dasgupta
    Department of Internal Medicine and the Barrett Cancer Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Mol Ther 13:183-93. 2006
    ..We conclude that anti-tumor activities of rvv-IL-2 are due to the induction of tumor-specific CD8+ CTL and CD4+ Th1-type helper T cells, and rvv-IL-2 may be used for treatment of HNSCC patients, since SCC VII/SF closely resembles HNSCC...
  99. ncbi Improved efficiency in detecting cellular immunity towards M. tuberculosis in patients receiving immunosuppressive drug therapy
    Urban Sester
    Department of Internal Medicine IV, Nephrology, University of the Saarland, D 66421 Homburg, Germany
    Nephrol Dial Transplant 21:3258-68. 2006
    ..The limited sensitivity of the established tuberculin skin-test in identifying latently infected patients on immunosuppressive drug therapy represents a major obstacle to better tuberculosis control after transplantation...
  100. ncbi Detection of cellular immunity to rabies antigens in human vaccinees
    Susan M Moore
    Department of Diagnostic Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    J Clin Immunol 26:533-45. 2006
    ....
  101. ncbi Analysis of the persistence of humoral and cellular immunity in children and adults immunized with varicella vaccine
    L Zerboni
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5208, USA
    J Infect Dis 177:1701-4. 1998
    The persistence of humoral and cellular immunity to varicella-zoster virus (VZV) was evaluated in 60 children and 18 adults immunized with live attenuated VZV vaccine...

Research Grants87

  1. Cellular Immunity to Category A-C Viruses in Humans
    Alan L Rothman; Fiscal Year: 2010
    ..expansion and detection of virus-specific T cells to facilitate broad application of assays of cellular immunity. Core facilities will provide program administration/educational outreach, pilot projects funding, and ..
  2. Cellular Immunity to Category A-C Viruses in Humans
    Alan L Rothman; Fiscal Year: 2010
    ..expansion and detection of virus-specific T cells to facilitate broad application of assays of cellular immunity. Core facilities will provide program administration/educational outreach, pilot projects funding, and ..
  3. Cellular Immunity to Category A-C Viruses in Humans
    Alan Rothman; Fiscal Year: 2009
    ..expansion and detection of virus-specific T cells to facilitate broad application of assays of cellular immunity. Core facilities will provide program administration/educational outreach, pilot projects funding, and ..
  4. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ..b>Cellular immunity directed against specific constituents of the peripheral nerve myelin sheath is considered causal in AIDP...
  5. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..throughput, proteome-based identification of antigens that have a high probability of inducing protective cellular immunity when formulated and administered as a vaccine...
  6. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2006
    ..throughput, proteome-based identification of antigens that have a high probability of inducing protective cellular immunity when formulated and administered as a vaccine...
  7. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2007
    ..throughput, proteome-based identification of antigens that have a high probability of inducing protective cellular immunity when formulated and administered as a vaccine...
  8. Use of Substance P antagonists to regulate the skin immune function
    Adriana T Larregina; Fiscal Year: 2010
    ..Substance-P (SP) is the prototype pro-inflammatory neuropeptide which favors cellular immunity by promoting the activation, proliferation and survival of immune cells...
  9. Use of Substance P antagonists to regulate the skin immune function
    Adriana Larregina; Fiscal Year: 2009
    ..Substance-P (SP) is the prototype pro-inflammatory neuropeptide which favors cellular immunity by promoting the activation, proliferation and survival of immune cells...
  10. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2001
    ..An important area of induction of cellular immunity to HIV that has not been much studied is the ability to induce CTL and humoral responses at mucosal surfaces...
  11. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2001
    ..An important area of induction of cellular immunity to HIV that has not been much studied is the ability to induce CTL and humoral responses at mucosal surfaces...
  12. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2000
    ..An important area of induction of cellular immunity to HIV that has not been much studied is the ability to induce CTL and humoral responses at mucosal surfaces...
  13. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth H Nardin; Fiscal Year: 2010
    ..has emphasized the critical need for more potent adjuvants to stimulate high levels of humoral and/or cellular immunity. TLR agonists based on unique pathogen associated molecular patterns (PAMPs) can function as strong ..
  14. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth Nardin; Fiscal Year: 2009
    ..has emphasized the critical need for more potent adjuvants to stimulate high levels of humoral and/or cellular immunity. TLR agonists based on unique pathogen associated molecular patterns (PAMPs) can function as strong ..
  15. Pilot--UV immunosuppression in cutaneous leishmaniasis
    FREDERICK HEINZEL; Fiscal Year: 2001
    ..Healing of leishmania is dependent on Th1-type CD4+ T cells producing interferon-gamma (IFNgamma). Curative cellular immunity may be impaired by repeated UV exposure of the infected site or early lesion, a situation which may be ..
  16. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 1999
    ..These actions account for changes in humoral and cellular immunity and have clinical applications in the treatment of venereal diseases, autoimmune diseases, malignancy, ..
  17. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 1992
    ..These actions account for changes in humoral and cellular immunity and have clinical applications in the treatment of venereal diseases, autoimmune diseases, malignancy, ..
  18. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 2001
    ..These actions account for changes in humoral and cellular immunity and have clinical applications in the treatment of venereal diseases, autoimmune diseases, malignancy, ..
  19. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 2000
    ..These actions account for changes in humoral and cellular immunity and have clinical applications in the treatment of venereal diseases, autoimmune diseases, malignancy, ..
  20. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 1993
    ..These actions account for changes in humoral and cellular immunity and have clinical applications in the treatment of venereal diseases, autoimmune diseases, malignancy, ..
  21. 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Stavros Manolagas; Fiscal Year: 1991
    ....
  22. MACROPHAGE AGGLUTINATION FACTOR
    Henry Godfrey; Fiscal Year: 1990
    Alterations in cellular immunity and in production of lymphokines (non-immunoglobulin mediators of immune responses) occur in patients with diseases ranging from cancer to occupationally- acquired allergic contact dermatitis...
  23. Impact of Calorie Restriction on Thymopoiesis in Humans
    VISHWA DIXIT; Fiscal Year: 2009
    ..The decline in cellular immunity with age is a direct consequence of progressive replacement of thymic lymphoid and stromal cell compartment ..
  24. Impact of Calorie Restriction on Thymopoiesis in Humans
    Vishwa Deep Dixit; Fiscal Year: 2010
    ..The decline in cellular immunity with age is a direct consequence of progressive replacement of thymic lymphoid and stromal cell compartment ..
  25. SECRETORY GRANULE PROTEOGLYCANS AND CELLULAR IMMUNITY
    Richard Stevens; Fiscal Year: 1991
    ..Antibodies will be raised that recognize the peptide core of the mouse proteoglycan to study the translation and glycosaminoglycan modification of this proteoglycan in transfected cells...
  26. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
    ..is acquired by inhalation and there is consensus that an effective host response in the lung involves cellular immunity. However, there is also overwhelming evidence from many laboratories that antibody-mediated immunity can ..
  27. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2005
    ..is acquired by inhalation and there is consensus that an effective host response in the lung involves cellular immunity. However, there is also overwhelming evidence from many laboratories that antibody-mediated immunity can ..
  28. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
    ..is acquired by inhalation and there is consensus that an effective host response in the lung involves cellular immunity. However, there is also overwhelming evidence from many laboratories that antibody-mediated immunity can ..
  29. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2006
    ..is acquired by inhalation and there is consensus that an effective host response in the lung involves cellular immunity. However, there is also overwhelming evidence from many laboratories that antibody-mediated immunity can ..
  30. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2004
    ..is acquired by inhalation and there is consensus that an effective host response in the lung involves cellular immunity. However, there is also overwhelming evidence from many laboratories that antibody-mediated immunity can ..
  31. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2002
    ..is acquired by inhalation and there is consensus that an effective host response in the lung involves cellular immunity. However, there is also overwhelming evidence from many laboratories that antibody-mediated immunity can ..
  32. Role of anti-Col (V) immunity in primary graft dysfunction
    David S Wilkes; Fiscal Year: 2010
    ..Recent work by our group suggests that both humoral and cellular immunity to col(V) are involved in PGD pathogenesis...
  33. IMMUNITY & VIRAL REPLICATION IN CHILDREN WITH VARICELLA
    Ann Arvin; Fiscal Year: 1993
    ..The importance of VZV cellular immunity is illustrated by the severity of varicella in children with T-cell deficiencies...
  34. IMMUNITY & VIRAL REPLICATION IN CHILDREN WITH VARICELLA
    Ann Arvin; Fiscal Year: 1992
    ..The importance of VZV cellular immunity is illustrated by the severity of varicella in children with T-cell deficiencies...
  35. IMMUNITY & VIRAL REPLICATION IN CHILDREN WITH VARICELLA
    Ann Arvin; Fiscal Year: 1990
    ..The importance of VZV cellular immunity is illustrated by the severity of varicella in children with T-cell deficiencies...
  36. IMMUNITY & VIRAL REPLICATION IN CHILDREN WITH VARICELLA
    Ann Arvin; Fiscal Year: 1991
    ..The importance of VZV cellular immunity is illustrated by the severity of varicella in children with T-cell deficiencies...
  37. INNATE/ADAPTIVE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUM
    Muyiwa Awoniyi; Fiscal Year: 2009
    ..contain the infection during the first days and then promote the development of adaptive, antigen-specific cellular immunity to the invading microbe, which must take place in a timely manner and be of proper magnitude and quality to ..
  38. Development of Vaccine Strategies to prevent EBV+ Lymphoma in Patients with HIV
    Robert Baiocchi; Fiscal Year: 2009
    ..We hypothesize that deficiency of cellular immunity against EBV lytic and latent antigens leads to increased risk of EBV-LPD, and vaccine-enhanced EBV-specific ..
  39. Development of Vaccine Strategies to prevent EBV+ Lymphoma in Patients with HIV
    ROBERT ALAN BAIOCCHI; Fiscal Year: 2010
    ..We hypothesize that deficiency of cellular immunity against EBV lytic and latent antigens leads to increased risk of EBV-LPD, and vaccine-enhanced EBV-specific ..
  40. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2006
    ..chaffeensis and other closely related organisms. ..
  41. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2003
    ..chaffeensis and other closely related organisms. ..
  42. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2004
    ..chaffeensis and other closely related organisms. ..
  43. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2005
    ..chaffeensis and other closely related organisms. ..
  44. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2007
    ..chaffeensis and other closely related organisms. ..
  45. IMMUNE RESPONSE TO THYROID PEROXIDASE IN THYROID CANCER
    James Baker; Fiscal Year: 1993
    ..In this disorder, an intense lymphocytic thyroiditis is associated with cytotoxic cellular immunity to thyroid cells and eventually results in the destruction of the thyroid...
  46. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2009
    ..While the rF1V vaccine primarily stimulates antibody-mediated humoral immunity, T cell-dependent cellular immunity comprises a second means by which vaccines can prime long-lived protection...
  47. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    David Rosenstein; Fiscal Year: 2000
    ..The primary hypothesis is that assessment of both cellular immunity depletion as well as residual cellular immunity function will be accurate predictors for endodontic success ..
  48. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    David Rosenstein; Fiscal Year: 2001
    ..The primary hypothesis is that assessment of both cellular immunity depletion as well as residual cellular immunity function will be accurate predictors for endodontic success ..
  49. Dynamics of SHIV clade C and S mansoni coinfection
    Ruth Ruprecht; Fiscal Year: 2005
    ..In addition, animal model studies have shown that vaccines that normally induce strong cellular immunity failed to do so in Schistosoma mansoni-infected animals...
  50. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    Gary Chiodo; Fiscal Year: 1999
    ..The primary hypothesis is that assessment of both cellular immunity depletion as well as residual cellular immunity function will be accurate predictors for endodontic success ..
  51. AGBD T CELL DEPENDENT MECHANISMS OF GLOMERULONEPHRITIS
    Tanya Mayadas; Fiscal Year: 2006
    There is compelling evidence that cellular immunity plays a role in the pathogenesis of glomerulonephritis (GN)...
  52. AGBD T CELL DEPENDENT MECHANISMS OF GLOMERULONEPHRITIS
    TANYA MAYADAS NORTON; Fiscal Year: 2003
    There is compelling evidence that cellular immunity plays a role in the pathogenesis of glomerulonephritis (GN)...
  53. Immunology and Outcomes after HAART in HIV/TB Coinfection
    Gregory P Bisson; Fiscal Year: 2012
    ..In another scenario delayed recovery of cellular immunity may be associated with inability to control opportunistic pathogens and death...
  54. Immunology and Outcomes after HAART in HIV/TB Coinfection
    Gregory P Bisson; Fiscal Year: 2010
    ..In another scenario delayed recovery of cellular immunity may be associated with inability to control opportunistic pathogens and death...
  55. Immunology and Outcomes after HAART in HIV/TB Coinfection
    Gregory P Bisson; Fiscal Year: 2010
    ..In another scenario delayed recovery of cellular immunity may be associated with inability to control opportunistic pathogens and death...
  56. Immunology and Outcomes after HAART in HIV/TB Coinfection
    Gregory Bisson; Fiscal Year: 2009
    ..In another scenario delayed recovery of cellular immunity may be associated with inability to control opportunistic pathogens and death...
  57. NEUROENDOCRINE EFFECTS ON HERPES SIMPLEX VIRUS IMMUNITY
    ROBERT BONNEAU; Fiscal Year: 1993
    ..animals have demonstrated that stressful events play a significant role in modulation of both humoral and cellular immunity. However, few studies have focused on elucidating the basic mechanisms that underlie stress-induced ..
  58. Cellular Immunity to Chlamydua at the Epithelial Interface
    Raymond Johnson; Fiscal Year: 2007
    ..Defining what protective T cells look like, and how they function, will be critical for designing and assessing future Chlamydia candidate vaccines. ..
  59. Cellular Immunity to Chlamydua at the Epithelial Interface
    Raymond Johnson; Fiscal Year: 2009
    ..Defining what protective T cells look like, and how they function, will be critical for designing and assessing future Chlamydia candidate vaccines. ..
  60. Cellular Immunity to Chlamydua at the Epithelial Interface
    Raymond Johnson; Fiscal Year: 2009
    ..Defining what protective T cells look like, and how they function, will be critical for designing and assessing future Chlamydia candidate vaccines. ..
  61. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2002
    ..chaffeensis and other closely related organisms. ..
  62. Immunotherapeutic HPV cancer vaccines that target Langerhans cells
    Gerard Zurawski; Fiscal Year: 2009
    ..A major immune arm of immunotherapeutic vaccines is cellular immunity. Studies have shown that the HPV oncoproteins, E6 and E7, are constitutively expressed in HPV-infected cells ..
  63. Immunotherapeutic HPV cancer vaccines that target Langerhans cells
    Gerard Zurawski; Fiscal Year: 2010
    ..A major immune arm of immunotherapeutic vaccines is cellular immunity. Studies have shown that the HPV oncoproteins, E6 and E7, are constitutively expressed in HPV-infected cells ..
  64. Integrase-defective lentiviral based influenza vaccines
    Mirella Salvatore; Fiscal Year: 2010
    A key problem in vaccine development is finding an effective way to induce cellular immunity. DNA vaccines are constituted by a plasmid encoding the target antigen under the transcriptional control of a promoter region active in human ..
  65. CELLULAR IMMUNITY TO ENDOGENOUS AKR LEUKEMIA VIRUSES
    William Green; Fiscal Year: 1990
    ..Definition of strageties to augment cell mediated responses to these weakly immunogenic antigens may have broad applicability to immune intervention to tumors in higher species...
  66. CORE--IMMUNOLOGY
    Lynn Morris; Fiscal Year: 2002
    ..provided by applicant): The CAPRISA Immunology Core will perform viral characterization, humoral and cellular immunity assays, HLA genotyping and" macrophage resistance assays in three separate laboratories at the National ..
  67. T CELL PHAGOCYTE INTERACTION IN ANTIMICROBIAL IMMUNITY
    Roger Kurlander; Fiscal Year: 1991
    Immune CD8 T cells are essential in cellular immunity against many intracellular pathogens including Listeria monocytogenes...
  68. Integrase-defective lentiviral based influenza vaccines
    Mirella Salvatore; Fiscal Year: 2009
    A key problem in vaccine development is finding an effective way to induce cellular immunity. DNA vaccines are constituted by a plasmid encoding the target antigen under the transcriptional control of a promoter region active in human ..
  69. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2010
    ..Evidence indicate that cellular immunity mediated by CD8 T cells is important in defense against LCMV, and most likely Lassa virus...
  70. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2007
    ..Evidence indicate that cellular immunity mediated by CD8 T cells is important in defense against LCMV, and most likely Lassa virus...
  71. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2009
    ..Evidence indicate that cellular immunity mediated by CD8 T cells is important in defense against LCMV, and most likely Lassa virus...
  72. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2004
    ..Evidence indicate that cellular immunity mediated by CD8 T cells is important in defense against LCMV, and most likely Lassa virus...
  73. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2005
    ..Evidence indicate that cellular immunity mediated by CD8 T cells is important in defense against LCMV, and most likely Lassa virus...
  74. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2006
    ..Evidence indicate that cellular immunity mediated by CD8 T cells is important in defense against LCMV, and most likely Lassa virus...
  75. Cell-mediated protection against pneumonic plague
    Stephen T Smiley; Fiscal Year: 2010
    ..While the rF1V vaccine primarily stimulates antibody-mediated humoral immunity, T cell-dependent cellular immunity comprises a second means by which vaccines can prime long-lived protection...
  76. HIV-1 MUCOSAL VACCINE CONSTRUCTS
    George Lewis; Fiscal Year: 1992
    ..goal of this project is to develop recombinant HIV-1 vaccine constructs that elicit both humoral and cellular immunity in both the mucosal and systemic compartments after oral immunization...
  77. AGBD T CELL DEPENDENT MECHANISMS OF GLOMERULONEPHRITIS
    Tanya Mayadas; Fiscal Year: 2004
    There is compelling evidence that cellular immunity plays a role in the pathogenesis of glomerulonephritis (GN)...
  78. AGBD T CELL DEPENDENT MECHANISMS OF GLOMERULONEPHRITIS
    Tanya Mayadas; Fiscal Year: 2005
    There is compelling evidence that cellular immunity plays a role in the pathogenesis of glomerulonephritis (GN)...
  79. DIMETHYLNITROSAMINE EFFECTS ON CELLULAR IMMUNITY
    Lawrence Schook; Fiscal Year: 1992
    ..Thus, this approach will permit us to establish a model for making risk assessments following DMN exposure. Finally, experiments will be conducted to determine whether there is a genetic component to DMN-induced changes...
  80. AGBD T CELL DEPENDENT MECHANISMS OF GLOMERULONEPHRITIS
    TANYA MAYADAS NORTON; Fiscal Year: 2002
    There is compelling evidence that cellular immunity plays a role in the pathogenesis of glomerulonephritis (GN)...