Genomes and Genes
Summary: The secretion of saliva which serves to moisten and soften food and keep the mouth moist. (From Dorland, 28th ed)
Publications220 found, 100 shown here
- Impact of dry mouth and hyposalivation on oral health-related quality of life of elderly JapaneseKazunori Ikebe
Division of Oromaxillofacial Regeneration Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:216-22. 2007..To determine the association of hyposalivation and the perception of dry mouth with oral health-related quality of life for independently living elderly...
- Parotid and submandibular/sublingual salivary flow during high dose radiotherapyF R Burlage
Department of Radiotherapy, University Hospital, P.O. Box 30.0019700 RB, Groningen, The Netherlands
Radiother Oncol 61:271-4. 2001..Neither recovery nor significant differences were observed between the production of saliva from the parotid and submandibular/sublingual glands during the 13 weeks observation period...
- Saliva and gastrointestinal functions of taste, mastication, swallowing and digestionA M Pedersen
Copenhagen Gerodontological Oral Health Research Centre, Department of Clinical Oral Physiology, Anatomy, Pathology and Medicine, School of Dentistry, Denmark
Oral Dis 8:117-29. 2002..Finally, pathophysiological considerations of salivary dysfunction in relation to some GI functions are considered...
- Nicotine delivery and subjective effects of Swedish portion snus compared with 4 mg nicotine polacrilex chewing gumErik Lunell
CROel AB, Helsingborg, Sweden
Nicotine Tob Res 13:573-8. 2011..Snus availability has been claimed to have contributed to the low rates of smoking among Swedish men and made possible the transfer to a less harmful form of nicotine dependence...
- Review: The physiology of saliva and transfer of drugs into salivaJohan K M Aps
UZG P8 Department of Paediatric Dentistry and Centre for Special Care, PaeCaMed Research Unit, Ghent University, De Pintelaan 185, 9000 Gent, Belgium
Forensic Sci Int 150:119-31. 2005..Consequently, it can be used in clinically difficult situations, such as in children, handicapped and anxious patients, where blood sampling could be a difficult act to perform...
- The role of age and salivation in acid clearance in symptomatic patients with gastro-oesophageal reflux diseaseW C Orr
Lynn Institute for Health Care Research, Oklahoma City, OK 73112, USA
Aliment Pharmacol Ther 15:1385-8. 2001..CONCLUSIONS: Cholinergic stimulation of salivation is an effective means of facilitating oesophageal acid clearance...
- Oral medicine -- update for the dental practitioner: dry mouth and disorders of salivationC Scully
Eastman Dental Institute for Oral Health Care Sciences, 256 Gray s Inn Road, UCL, University of London, London WC1X 8LD, UK
Br Dent J 199:423-7. 2005..Guidance on management and when to refer is also provided, along with relevant websites which offer further detail...
- Salivation triggered by pilocarpine involves aquaporin-5 in normal rats but not in irradiated ratsTetsuya Asari
Pharmacology Research Laboratory, Kissei Pharmaceutical Co Ltd, Azumino, Nagano, Japan
Clin Exp Pharmacol Physiol 36:531-8. 2009....
- Comparative evaluation of exocrine muscarinic receptor binding characteristics and inhibition of salivation of solifenacin in miceTomomi Oki
Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
Biol Pharm Bull 29:1397-400. 2006..The aim of the present study was to characterize the suppression of cholinergic salivation and exocrine muscarinic receptor binding of solifenacin on oral administration to mice in comparison with those ..
- Application of umami taste stimulation to remedy hypogeusia based on reflex salivationTakashi Sasano
Division of Oral Diagnosis and Radiology, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
Biol Pharm Bull 33:1791-5. 2010..Moreover, clinical studies have shown that treatment of hyposalivation diminishes hypogeusia, indicating that salivation is essential to maintain normal taste function...
- Modulation of salivation and heartburn in response to the site of acid infusion in the human oesophagusS K Dutta
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
Aliment Pharmacol Ther 32:795-800. 2010The pathogenesis of gastro-oesophageal reflux disease includes increased acid reflux, reduced salivation and impaired peristalsis. This may depend upon the height of acid wave and magnitude of oesophageal mucosal exposure...
- Drug effects on salivary glands: dry mouthC Scully
International Centres for Excellence in Dentistry and Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, UK
Oral Dis 9:165-76. 2003..To identify drugs associated with the complaint of dry mouth...
- Unstimulated salivary flow rate, pH and buffer capacity of saliva in healthy volunteersC Fenoll-Palomares
Medicina Familiar y Comunitaria, Centro de Atención Primaria, Rafelbunyol, Valencia, Spain
Rev Esp Enferm Dig 96:773-83. 2004....
- Aging and secretory reserve capacity of major salivary glandsE M Ghezzi
University of Michigan School of Dentistry, Department of Cariology, Restorative Sciences, and Endodontics, Ann Arbor, USA
J Dent Res 82:844-8. 2003..These findings suggest that salivary gland output is more adversely affected by an anti-sialogogue in healthy older vs. younger adults, supporting the secretory reserve hypothesis of salivary function...
- Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in miceTomomi Oki
Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Science, University of Shizuoka, Suruga ku, Shizuoka 422 8526, Japan
Eur J Pharmacol 529:157-63. 2006..oral administration of tolterodine on muscarinic receptor binding in the bladder and submaxillary gland and on salivation in mice...
- Age-related changes in unstimulated salivary function and composition and its relations to medications and oral sensorial complaintsRafael M Nagler
Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Aging Clin Exp Res 17:358-66. 2005..OSC cover xerostomia, disturbed sense of taste, or burning mouth sensitivity with no established classical etiology (e.g., Sjogren's syndrome, or a response to radiotherapy)...
- Salivary secretion, taste and hyposalivationH Mese
Department of Oral and Maxillofacial Surgery, and Biopathological Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
J Oral Rehabil 34:711-23. 2007..This article reviews the mechanism of salivary secretion, effect of saliva on taste, importance of saliva in oral health, and hyposalivation in relation to ageing, medicine and/or disease and management of hyposalivation...
- Minor gland and whole saliva in postmenopausal women using a low potency oestrogen (oestriol)L Eliasson
Department of Cariology, Faculty of Odontology, Sahlgrenska Academy at Goteborg University, PO Box 450, SE 405 30 Goteborg, Sweden
Arch Oral Biol 48:511-7. 2003..Thus, the present findings indicate that a low dose oestrogen (oestriol) may affect the flow rate of labial salivary glands and the bacterial aggregation activity of whole saliva...
- The cholinesterase inhibitor physostigmine for the local treatment of dry mouth: a randomized studyNina Khosravani
Section of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
Eur J Oral Sci 117:209-17. 2009..Physostigmine, applied locally, therefore appears to be a promising modality for dry-mouth treatment...
- Lesions of the lateral hypothalamus impair pilocarpine-induced salivation in ratsA Renzi
Department of Physiology and Pathology, School of Dentistry, Paulista State University, SP, Araraquara, Brazil
Brain Res Bull 58:455-9. 2002In the present study we investigated the effects of electrolytic lesions of the lateral hypothalamus (LH) in the salivation induced by intracerebroventricular (i.c.v.) or intraperitoneal (i.p...
- Possible role of nitric oxide in radiation-induced salivary gland dysfunctionIenaka Takeda
Department of Oral Medicine, Tokyo Dental College, Chiba, Japan
Radiat Res 159:465-70. 2003..The finding that administration of an inhibitor of NO synthesis ameliorated the dysfunction of irradiated salivary glands indicates that NO plays a role as a mediator of the dry mouth symptoms that occur after irradiation...
- Central alpha(2) adrenergic receptors and cholinergic-induced salivation in ratsAna Carolina Thomaz Takakura
Department of Physiology and Pathology, School of Dentistry, Paulista State University, UNESP, Araraquara, SP, Brazil
Brain Res Bull 59:383-6. 2003b>Salivation induced by intraperitoneal (i.p.) injections of pilocarpine (cholinergic agonist) is reduced by intracerebroventricular (i.c.v.) injections of moxonidine (alpha(2) adrenergic and imidazoline receptor agonist)...
- Salivation pattern of Rhodnius prolixus (Reduviidae; Triatominae) in mouse skinAdriana Coelho Soares
Departamento de Parasitologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Presidente Antonio Carlos, 6627, Campus Pampulha, Belo Horizonte, Minas Gerais, CEP 31270 901, Brazil
J Insect Physiol 52:468-72. 2006The objective of this work was to study the pattern of salivation of triatomines during feeding in mouse skin. Rhodnius prolixus was fed with a solution of the dye acridine orange or fluorescein...
- Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in miceTomomi Oki
Department of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Br J Pharmacol 145:219-27. 2005..It is concluded that oral solifenacin persistently binds to muscarinic receptors in tissues expressing the M(3) subtype, such as the bladder...
- [A case with left mesial temporal lobe epilepsy characterized by abnormal massive salivation]M Morita
Department of Neurology, Jikei University School of Medicine
Rinsho Shinkeigaku 41:809-12. 2001..Every seizure began with an upper abdominal discomfort, and often followed by massive salivation. Whenever the epileptic salivation happened, the patient lost consciousness, and sometimes she developed ..
- Central muscarinic receptors signal pilocarpine-induced salivationA C T Takakura
Department of Physiology and Pathology, School of Dentistry, Paulista State University UNESP, Rua Humaita, 1680, 14801 903, Araraquara, SP, Brazil
J Dent Res 82:993-7. 2003..cholinergic agonists such as pilocarpine injected peripherally can act directly on salivary glands to induce salivation, it is possible that their action in the brain may contribute to salivation...
- Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout miceF P Bymaster
Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
Life Sci 68:2473-9. 2001..M2 and M4 muscarinic receptor knockout mice revealed that M2 receptors mediated tremor and hypothermia, but not salivation. The M4 receptors seem to play a modest role in salivation, but did not alter hypothermia and tremor...
- Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient miceR L Evans
Center for Oral Biology, Aab Institute of Biomedical Sciences and the Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 275:26720-6. 2000..reduction (>60%) in the volume of saliva secreted in response to a muscarinic agonist, the primary in situ salivation signal...
- Effects of furosemide and bendroflumethiazide on saliva flow rate and compositionT Nederfors
Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Arch Oral Biol 49:507-13. 2004....
- Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphyMarc W Munter
Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 58:175-84. 2004..To evaluate salivary gland function after inversely planned stereotactic intensity-modulated radiotherapy (IMRT) for tumors of the head-and-neck region using quantitative pertechnetate scintigraphy...
- Clinical and biochemical evaluation of the saliva of patients with xerostomia induced by radiotherapyCássio de Barros Pontes
Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo
Braz Oral Res 18:69-74. 2004..Clinically, patients presenting xerostomia induced by radiotherapy presented an increase in oral tissue injury...
- [Usefulness of pilocarpine in the prevention of xerostomia in patients with head and neck cancer treated with radiotherapy. Assessment with gammagraphy and salivary flow]S Fuertes Cabero
Servicio de Medicina Nuclear Hospital Clínic de Barcelona Universidad de Barcelona Spain
Rev Esp Med Nucl 23:259-66. 2004..To assess the utility of salivary gland scintigraphy and salivary flow to quantify salivary function and to evaluate the usefulness of pilocarpine in the treatment of radiation-induced xerestomia in head and neck cancer patients...
- Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumorsCássia Maria Fischer Rubira
Stomatology Department, School of Dentistry of Bauru, University of Sao Paulo, Brazil
Braz Oral Res 21:272-7. 2007..The main effect of radiotheraphy in the head and neck region was a reduction of the salivary flow rate, even though our study demonstrated that there was a modest late improvement of the salivary flow...
- In regards to Münter et Al. (Int J Radiat Oncol Biol Phys 2007;67:651-659)Michael A Samuels
Int J Radiat Oncol Biol Phys 69:318; author reply 318-9. 2007
- Salivary enhancement therapiesPhilip C Fox
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Caries Res 38:241-6. 2004..With improved secretagogues, the effects of conditions that result in reduced salivary function and increased caries will be ameliorated...
- Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiationYasuhiro Omori
Clinical Development, Kissei Pharmaceutical Co, Ltd, Hotaka, Nagano, Japan
Arzneimittelforschung 53:342-50. 2003..These results suggest that pilocarpine hydrochloride could be used as a sialagogic drug for postirradiation-induced xerostomia with fewer adverse effects on the CNS...
- Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome, xerostomia and/or gustatory disturbancesOded Hershkovich
Oral Biochemistry Laboratory and Salivary Clinic, Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Rambam Medical Center, Technion Israel Institute of Technology, P O B 9602, Haifa 31096, Israel
Arch Oral Biol 49:515-22. 2004..In the current study, we performed taste and salivary analysis on patients suffering from burning mouth syndrome and xerostomia or taste disturbances...
- [The role of saliva in maintaining oral health]P Defabianis
Dipartimento di Odontostomatologia, Azienda Ospedaliera S Giovanni Battista di Torino, Universita degli Studi di Torino, Torino, Italy
Minerva Stomatol 52:301-8. 2003..The action of saliva and the multifunctional aspects of its components in both detrimental and beneficial effects on oral health are underlined...
- [Enduring oral dryness after acne treatment]C P Bots
Afdeling Tandheelkundige Basiswetenschappen, Sectie Orale Biochemie van het Academisch Centrum Tandheelkunde Amsterdam ACTA
Ned Tijdschr Tandheelkd 110:295-7. 2003..It is suggested to register and monitor the use of medication in patients with sudden oral health changes...
- Salivary gland function and xerostomia in southern Chinese following radiotherapy for nasopharyngeal carcinomaEdmond H N Pow
Oral Rehabilitation, Faculty of Dentistry, University of Hong Kong, 34 Hospital Road, Hong Kong
Clin Oral Investig 7:230-4. 2003..In irradiated and non-irradiated southern Chinese, subjective dry mouth symptoms appeared to be correlated with actual salivary gland function...
- Sialochemical and gustatory analysis in patients with oral sensory complaintsRafael M Nagler
Department of Oral and Maxillofacial Surtery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Haifa, Israel
J Pain 5:56-63. 2004..This report might add an important objective diagnostic tool to the clinician treating such patients...
- [Experimental and clinical investigations on the inhibition of secretion of the major salivary glands with botulinum toxin A]M Ellies
HNO Klinik der Georg August Universität Göttingen
Laryngorhinootologie 82:713-4. 2003
- Evaluation of salivary flow in patients during head and neck radiotherapyPaulo Rogerio Ferreti Bonan
School of Dentistry, University of Alfenas, USA
Pesqui Odontol Bras 17:156-60. 2003..0008), which continued low immediately after radiotherapy (p = 0.0009). Our study showed that radiotherapy leads to an important reduction of salivary flow during and after radiotherapy...
- Saliva secretion and abnormal moistening of oral mucosa after bone marrow transplantationAgnieszka Bogusławska-Kapała
Department of Conservative Dentistry, Medical University of Gdansk, Poland
Bull Group Int Rech Sci Stomatol Odontol 47:1-5. 2006..Those with normal moistening exhibited average rates of both stimulated and non-stimulated saliva secretion significantly higher than patients with abnormal moistening of oral mucosa...
- Association between regional idiopathic neuropathy and salivary involvement as the possible mechanism for oral sensory complaintsMichal Granot
Faculty of Social Welfare and Health Studies, University of Haifa, Haifa, Israel
J Pain 6:581-7. 2005..Alternatively, a primary idiopathic salivary dysfunction might cause sensory neural dysfunction at the receptor level by changing the oral cavity milieu...
- Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?Anke Petra Jellema
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
Radiother Oncol 77:164-71. 2005..To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva...
- Xerostomia: a clinical approachDavid M Lewis
Department of Oral and Maxillofacial Pathology, OUCOD
J Okla Dent Assoc 97:22-5. 2005
- Assessment of the use of sialogogues in the clinical management of patients with xerostomiaNita Chainani-Wu
Department of Orofacial Sciences, University of California, San Francisco, Calif, USA
Spec Care Dentist 26:164-70. 2006..The observed carryover effect suggests that intermittent treatment may be an alternative to continuous treatment with sialogogues...
- Gender difference in unstimulated whole saliva flow rate and salivary gland sizesH Inoue
Department of Biosciences, Kyushu Dental College, 2 6 1 Manazuru, Kokurakitaku, Kitakyushu, Fukuoka 803 8580, Japan
Arch Oral Biol 51:1055-60. 2006..In this study, we investigated the relationships among the UWSFR, gland sizes and body sizes of healthy young adult males and females...
- Dramatic and prolonged decrease of whole salivary secretion in nasopharyngeal carcinoma patients treated with radiotherapyYee Min Jen
Department of Radiation Oncology, Tri Service General Hospital, Taipei, Taiwan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:322-7. 2006....
- The rôle of saliva in maintaining oral health and as an aid to diagnosisCarmen Llena-Puy
Department 9, Valencian Health Service, CEU Cardenal Herrera University
Med Oral Patol Oral Cir Bucal 11:E449-55. 2006..Its advantages as a diagnostic tool include its being easy to obtain and the positive correlation between many parameters in serum and saliva...
- A simple test for salivary gland hypofunction using Oral Schirmer's testPía López-Jornet
Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Spain
J Oral Pathol Med 35:244-8. 2006..The objective of this study was to develop a test for detecting salivary gland hypofunction...
- Dental plaque pH and micro-organisms during hyposalivationL Eliasson
Department of Cariology, Faculty of Odontology, The Sahlgrenska Academy at Goteborg University, Box 450, SE 405 30 Goteborg, Sweden
J Dent Res 85:334-8. 2006..Stepwise regression tests suggested that the buccal minor-salivary-gland secretion rate in the test groups and counts of mutans streptococci in the controls were of significant importance for dental plaque pH...
- The relationship between the levels of salivary cortisol and the presence of xerostomia in menopausal women. A preliminary studyBegoña Rivera Gómez
Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontologia, UCM, Madrid
Med Oral Patol Oral Cir Bucal 11:E407-12. 2006..Xerostomia is a particularly frequent occurrence among menopausal women, and is often associated with depression...
- Effects of homeopathic treatment on salivary flow rate and subjective symptoms in patients with oral dryness: a randomized trialS Haila
Porin Hammaspiste, Pori, Finland
Homeopathy 94:175-81. 2005..The symptoms of xerostomia improved in both groups. Our results suggest that individually prescribed homeopathic medicine could be a valuable adjunct to the treatment of oral discomfort and xerostomic symptoms...
- Intensity-modulated radiation therapy and xerostomiaMark S Chambers
Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Calif Dent Assoc 34:743-8. 2006....
- Adjuvant chemotherapy in breast cancer patients induces temporary salivary gland hypofunctionSiri Beier Jensen
Department of Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Institute of Odontology, Faculty of Health Sciences, University of Copenhagen, Norre Alle 20, DK 2200 Copenhagen N, Denmark
Oral Oncol 44:162-73. 2008..Thus, the results suggest that acinar and ductal cell functions are affected by adjuvant CT. These adverse drug reactions are temporary, as salivary findings generally returned to baseline values within one year following treatment...
- Relationships between age, drugs, oral sensorial complaints and salivary profileRafael M Nagler
Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Centre and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Arch Oral Biol 50:7-16. 2005....
- Opposite effects of antidepressants on unstimulated and stimulated salivary flowLuciane Kopittke
Division of Pharmacology, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Rua Sarmento Leite 245, 3rd Floor, 90050 170 Porto Alegre, RS, Brazil
Arch Oral Biol 50:17-21. 2005..The same opposite pattern of effects on non-stimulated and pilocarpine-stimulated salivation was seen after chronic treatment with the antidepressants...
- Salivary gland parameters and clinical data related to the underlying disorder in patients with persisting xerostomiaIanthe van den Berg
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur J Oral Sci 115:97-102. 2007..Xerostomia-inducing medication was used by most patients. It was concluded that gland-specific sialometry and sialochemistry is useful in discriminating between the various disorders causing persisting xerostomia...
- Effect of cevimeline on salivary components in patients with Sjögren syndromeKimihiro Suzuki
Internal Medicine I, National Defense Medical College, Tokorozawa, Japan
Pharmacology 74:100-5. 2005..It may be beneficial for SS patients to continue taking cevimeline to prevent oral infections, and other serious sequelae...
- Efficacy of the BioXtra dry mouth care system in the treatment of radiotherapy-induced xerostomiaPiet Dirix
Department of Radiation Oncology, Leuvens Kanker Instituut, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
Support Care Cancer 15:1429-36. 2007..Symptomatic treatment consists of stringent oral hygiene to prevent oral infections and saliva substitutes to increase comfort. The aim of the study was to evaluate the clinical effectiveness of the BioXtra (BX) dry mouth care system...
- Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without AmifostineMarc W Munter
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 67:651-9. 2007....
- The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapyYun Li
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
Int J Radiat Oncol Biol Phys 67:660-9. 2007..Our purpose is to investigate the relationship between radiation dose and saliva changes in the 2 years after treatment...
- Pathophysiology and management of radiation-induced xerostomiaLawrence B Berk
Newark Radiation Oncology, Newark, Ohio, USA
J Support Oncol 3:191-200. 2005..This article will review current knowledge concerning the anatomy and function of glands involved with salivation, measurement of salivary gland function, surgical and pharmacologic prevention and treatment of xerostomia, and ..
- Gland size estimation and body mass index improve salivary flow rate assessmentC Dawes
Department of Oral Biology, 780 Bannatyne Avenue, Winnipeg, Man R3E 0W2, Canada
Arch Oral Biol 52:409-10. 2007
- Progression of salivary gland dysfunction in patients with Sjogren's syndromeJ Pijpe
University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
Ann Rheum Dis 66:107-12. 2007..Salivary gland dysfunction is one of the key manifestations of Sjögren's syndrome...
- Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease--a prolonged studyR M Nagler
Sheba Medical Center, Tel Hashamer, Israel
Cancer Invest 21:34-40. 2003....
- Alterations of nitrate and nitrite content in saliva, serum, and urine in patients with salivary dysfunctionDengsheng Xia
Salivary Gland Disease Center, Faculty of Stomatology, Capital University of Medical Sciences, Beijing, 00050, PR China
J Oral Pathol Med 32:95-9. 2003..The role of the salivary glands in the maintenance of nitrate and nitrite in saliva is poorly understood. The aim was to study alterations of nitrate and nitrite metabolisms in patients with Sjogren's syndrome (SS) or sialosis...
- Submandibular and sublingual salivary gland function in familial dysautonomiaAndy Wolff
Hospital Dentistry Department, Assuta Hospital and Maccabi Health Services, Tel Aviv, Israel
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:315-9. 2002..Drooling in familial dysautonomia (FD) has been attributed to denervation supersensitivity. The aim of this study was to investigate submandibular and sublingual (SM/SL) gland function in FD...
- Decreased saliva secretion and down-regulation of AQP5 in submandibular gland in irradiated ratsZhimin Li
Department of Oral Radiology, College of Stomatology, Jilin University, Changchun, China
Radiat Res 165:678-87. 2006..These results suggest that the preferential down-regulation of AQP5 with minor effects on AQP1 and Na(+)/K(+)-ATPase may contribute to radiation-induced salivary dysfunction...
- Saliva substitutes: how effective and safe are they?D Y D Samarawickrama
Oral Dis 8:177-9. 2002
- Effects of antidepressants and benzodiazepines on stimulated salivary flow rate and biochemistry composition of the salivaPatricia Del Vigna de Almeida
Department of Stomatology, School of Dentistry, Pontificia Universidade Catolica do Parana, Curitiba, Brazil
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:58-65. 2008....
- Association of oral yeast carriage with specific host factors and altered mouth sensationChika Shimizu
Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:445-51. 2008..The aim of this study was to determine if there was a significant association between the presence of altered mouth and taste sensations with oral carriage of yeasts and to assess the factors that influence the yeast carriage...
- Inadequate salivary flow and poor oral mucosal status in intubated intensive care unit patientsPaul Dennesen
Department of Medical Microbiology, University Hospital of Maastricht, The Netherlands
Crit Care Med 31:781-6. 2003..In addition, the pattern of oropharyngeal colonization was investigated in these patients...
- A new medication for treatment of dry mouth in SjÃ¶gren's syndromeI al-Hashimi
Salivary Dysfunction Clinic, Department of Periodontics, Baylor College of Dentistry, TAMUS-HSC, Dallas, TX, USA
Tex Dent J 118:262-6. 2001..Both Salagen and Evoxac are FDA approved salivary stimulants. They are effective, and safe given awareness of their indications, contraindications, potential adverse effects, and patient's tolerance...
- Salivary flow rates measured during radiation therapy in head and neck cancer patients: a pilot study assessing salivary sediment formationMark S Chambers
Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Prosthet Dent 100:142-6. 2008..Determining the impact that salivary sediments have on measured salivary flow rates during radiation is important for management of patients...
- Effect of Pilocarpine on impaired salivary secretion in patients with Sjögren's syndromeLars Jorkjend
Section of Dental Pharmacology and Pharmacotherapy, University of Oslo, Norway
Swed Dent J 32:49-56. 2008..05), but not a RWS, rate at baseline. It is concluded that a subgroup of Sjögren patients do not respond to Pilocarpine stimulation. The clinical implications of this finding need further investigation...
- Nizatidine enhances salivary secretion in patients with dry mouthT Nin
Department of Otolaryngology, Hyogo College of Medicine, 1 1 Mukogawa, Nishinomiya City, Hyogo 663 8501, Japan
Auris Nasus Larynx 35:224-9. 2008..The aim of the present study was to investigate whether or not nizatidine enhances salivary secretion and improves the function of salivary glands in patients with dry mouth...
- The effects of duration and intensity of stimulation on total protein and mucin concentrations in resting and stimulated whole salivaS A Rayment
Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University School of Medicine, Boston University Medical Center, MA 02118, USA
J Dent Res 80:1584-7. 2001....
- Making a meaningful difference for the patientCharles W Scarantino
Triangle Radiation Oncology Services, Rex Cancer Center, Raleigh, North Carolina 27607, USA
J Support Oncol 3:207-8. 2005
- Up-to-date report of botulinum toxin therapy in patients with drooling caused by different etiologiesMaik Ellies
Department of Otorhinolaryngology, Head and Neck Surgery, University of Gottingen, Gottingen, Germany
J Oral Maxillofac Surg 61:454-7. 2003..We also present a controlled follow-up study documenting efficiency, possible adverse events, and duration of the effect of treatment...
- In regard to Münter et Al. Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and withouGerald L Messerschmidt
Int J Radiat Oncol Biol Phys 69:1651-2; author reply 1652. 2007
- Saliva: a fountain of opportunityMahvash Navazesh
Division of Diagnostic Sciences at University of Southern California School of Dentistry, 90089 0641, USA
J Calif Dent Assoc 30:783-8. 2002....
- Lack of oncogenicity of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in Sprague-Dawley ratsT Kuge
Taiko Pharmaceutical Company, Ltd, Suita, Osaka, Japan
Int J Toxicol 20:297-305. 2001..food consumption, as well as increased incidences of clinical signs that included rales, decreased activity, and salivation, were noted at 200 mg/kg bw/day when compared with the control group...
- [Anxiolysis, sedation, and stress reduction following oral premedication with midazolam in adults. A comparison with dipotassium clorazepate and placebo]E Berendes
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfalische Wilhelms Universitat Munster
Anaesthesist 45:506-11. 1996..room, the following parameters were determined with visual analogue scales (VAS): "asthenia," "depression," oral salivation, muscle tension, motoric restlessness and sweating of the palms...
- Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogsWang Soo Kim
Biomedical Section, Agency for Defense Development, Yuseong P O Box 35 1, Daejeon 305 600, Republic of Korea
Eur J Pharmacol 525:135-42. 2005..1 microg/kg, and high doses (> or = 1.4 LD50) of soman induced salivation, emesis, defecation and diarrhea, tremors and seizures, and recumbency of dogs, leading to 100% mortality in 24 ..
- Calcitonin gene-related peptide in rat salivary glands: neuronal localization, depletion upon nerve stimulation, and effects on salivation in relation to substance PJ Ekstrom
Department of Physiology, University of Lund, Sweden
Neuroscience 26:933-49. 1988..CGRP may interact positively with acetylcholine and certain nonclassical transmitters, and it may be involved (together with other neuropeptides) in the atropine-resistant parasympathetic secretion occurring in the glands under study...
- Acute toxicity and cholinesterase inhibition in chicks dosed orally with organophosphate insecticidesFouad K Mohammad
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
Arh Hig Rada Toksikol 59:145-51. 2008..Signs of cholinergic toxicosis in the chicks appeared within two hours after dosing, and they included salivation, lacrimation, gasping, frequent defecation, drooping of wings, tremors, convulsions, and recumbency before death...
- Hemifacial spasm non-motor and motor-related symptoms and their response to botulinum toxin therapyMonika Rudzinska
Department of Neurology, Jagiellonian University Medical College, 3 Botaniczna Str, 31 503 Krakow, Poland
J Neural Transm 117:765-72. 2010..disturbances, pain), motor (facial weakness, trismus, bruxism, dysarthria) and/or autonomic (lacrimation, salivation) symptoms...
- Experimental infection of cattle with Trypanosoma brucei rhodesienseB T Wellde
Walter Reed Project, Veterinary Research Laboratory, Ministry of Agriculture and Livestock Development, Kabete, Kenya
Ann Trop Med Parasitol 83:133-50. 1989..Clinical signs included fever, hyperkinesia, weight loss, cerebellar ataxia, tremor, salivation and hyperaesthesia. A mild to moderate anaemia accompanied a transient thrombocytopenia and leucopenia...
- A new low-dose formulation of selegiline: clinical efficacy, patient preference and selectivity for MAO-B inhibitionA Clarke
Scherer DDS, Swindon, United Kingdom
J Neural Transm 110:1257-71. 2003..Patients were stratified by the presence or absence of swallowing and salivation problems and were randomised to either Zydis Selegiline 5 mg or a placebo fast-dissolving formulation...
- The influence of pilocarpine and biperiden on pH value and calcium, phosphate, and bicarbonate concentrations in saliva during and after radiotherapy for head and neck cancerM Rode
Department of Stomatology, University of Ljubljana, Slovenia
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:509-14. 2001..study was to investigate the influence of parasympathomimetic pilocarpine and anticholinergic biperiden on salivation, pH value, and calcium, phosphate, and bicarbonate concentrations in saliva in patients irradiated for malignant ..
- Effects of Betel chewing on the central and autonomic nervous systemsN S Chu
Department of Neurology, Chang Gung Medical College and Memorial Hospital, Taipei, Taiwan, ROC
J Biomed Sci 8:229-36. 2001Betel chewing has been claimed to produce a sense of well-being, euphoria, heightened alertness, sweating, salivation, a hot sensation in the body and increased capacity to work...
- Safety reporting and adverse-event profile of mirtazapine described in randomized controlled trials in comparison with other classes of antidepressants in the acute-phase treatment of adults with depression: systematic review and meta-analysisNorio Watanabe
Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
CNS Drugs 24:35-53. 2010..Mirtazapine has a unique mechanism of antidepressant action, and thus is thought to have a different profile of adverse events from that of other antidepressants...
- Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model systemJ K Dunnick
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 35:657-64. 2007..medicine Ma Huang (ephedra) in combination with caffeine caused rapid clinical signs of toxicity including salivation, hyperactivity, ataxia, and eventually lethargy, and failure to respond to stimuli...
- Equine botulism and acute pasture myodystrophy: new soil-borne emerging diseases in Switzerland?V Gerber
Equine Clinic, Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Berne, Switzerland
Schweiz Arch Tierheilkd 148:553-9. 2006..Horses showing signs suggestive of botulism (muscle weakness and tremors, reduced tongue tone, slow chewing, salivation and difficulties swallowing, drooping eyelids, mydriasis), especially patients that have fed on suspect fodder (..
- Most common intoxication in nephrology ward organophosphate poisoningChun Liang Lin
Chang Gung Memorial Hospital, Pu tzu City, Chiayi, Taiwan
Ren Fail 26:349-54. 2004..To better understand the clinical significance of associated parameters on respiratory failure and patient outcome, we evaluate patients admitted to the Nephrology ward in our hospital with OP intoxication...
- Studies on tachykinin (neurokinin) receptor coupled with inositol phospholipid hydrolysis and salivation in rat salivary glandsJ W Wei
Institute of Neurosciences, National Yang Ming Medical College, Taipei, Taiwan
Chin J Physiol 35:291-301. 1992..When salivation was induced by natural occurring tachykinins and acetylcholine (via i.v...
- The use of a medetomidine, butorphanol and atropine combination to enable blood sampling in young pigsC E Ugarte
Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand
N Z Vet J 53:249-52. 2005..To determine the suitability of a reversible, injectable anaesthetic combination including medetomidine, butorphanol and atropine to produce the degree of immobilisation required to allow blood sampling in young pigs...
- Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposureMyra L Weiner
TOXpertise, LLC, Princeton, NJ 08540, USA
Neurotoxicology 30:S1-16. 2009..effects, including ones that are historically classified as causing a T (tremor), CS (choreoathetosis with salivation) or intermediate syndrome of intoxication, and others that have not previously been classified...
Research Grants108 found, 100 shown here
- NEURAL CONTROL OF TEMPERATURE REGULATIONJACK BOULANT; Fiscal Year: 2006..Responses include skin blood flow, evaporative heat loss (e.g., salivation/skin wetting, panting, sweating), shivering and non-shivering thermogenesis (via metabolic hormones and brown ..
- MOLECULAR ANALYSIS OF NEURAL MUSCARINIC RECEPTORSNEIL NATHANSON; Fiscal Year: 2001..help determine the involvement of the m1 and m4 receptors in such diverse responses as temperature regulation, salivation, tremor, seizure activity, striatal function, circadian rhythm, and memory...
- Ethnopharmacological Studies in Oral MedicineMichael Colvard; Fiscal Year: 2004..extracted, the extracts tested in oral related affections, such as pain, inflammation, cancerous growth, and salivation. An Agreement will be set up between the University of Illinois at Chicago and the Universidad Latina of Costa ..
- MECHANISMS OF ANION TRANSPORT IN SALIVARY GLANDSJames E Melvin; Fiscal Year: 2010..b>Salivation is a two step process...
- MECHANISMS OF ANION TRANSPORT IN SALIVARY GLANDSJAMES MELVIN; Fiscal Year: 2007..b>Salivation is a two step process...
- fMRI of the Mesolimbic Dopamine System in Risky DrinkersDavid Kareken; Fiscal Year: 2007..We will study changes in desire to drink and salivation following exposure to alcohol cues, and relate those changes to observed signal changes in fMRI...
- PHYSIOLOGY OF MUCUS-SECRETING SALIVARY GLANDSJAMES MELVIN; Fiscal Year: 2007..Ultimately, the information gained from these Aims will aid in the development of therapies to remedy various forms of salivary gland dysfunction. ..
- INNOVATIVE BIOMONITORING FOR LEAD IN SALIVACharles Timchalk; Fiscal Year: 2006..It is reasonable to speculate that once this model system has been adequately validated it can readily be employed to screen sensitive populations (e.g. children) that are at greatest risk from chronic Pb exposure. ..
- Non-Invasive Biomonitoring of PesticidesCharles Timchalk; Fiscal Year: 2007..Once this model system has been adequately validated it can readily be employed to assess worker exposure to insecticides under a wide range of occupational situations. ..
- MECHANISMS OF ANION TRANSPORT PROTEINS IN SALIVARY CELLSJAMES MELVIN; Fiscal Year: 1999....
- PHYSIOLOGY OF MUCUS-SECRETING SALIVARY GLANDSJAMES MELVIN; Fiscal Year: 2003..abstract_text> ..
- Insecticide Action at the Local Anesthetic ReceptorDAVID SODERLUND; Fiscal Year: 2007..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
- Development of Selective Nanoporous Sorbents for Radionuclide DecorporationCharles Timchalk; Fiscal Year: 2006....
- Bacteremia from Dental Extraction vs. Oral HygienePeter Lockhart; Fiscal Year: 2004..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
- Epidemilogy of Parkinsonism in WeldersBrad A Racette; Fiscal Year: 2011..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
- PARKINSON'S DISEASE NEUROPROTECTIVE TRIAL:CLINICAL CENTERBrad Racette; Fiscal Year: 2007..The MDC at Washington University School of Medicine provides the breadth of clinical and basic research experience required to be a productive site in this large, multi-center neuroprotective trial in PD. ..
- Brief Alcohol Intervention for School-to-Work TransitionsSuzanne Colby; Fiscal Year: 2009..The proposed research would test the effects of BMI specifically in the under-studied and under-treated population of heavy drinking non-college young adults. ..
- Epidemiology of Parkinsonism in WeldersBrad Racette; Fiscal Year: 2007..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
- ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTSPaul Moore; Fiscal Year: 2003..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
- Stress and Subsequent Drinking in Individuals with Different Drinking MotivesSuzanne Thomas; Fiscal Year: 2007....
- Supplementing Relaxation & Music for Postoperative PainMarion Good; Fiscal Year: 2004..Knowledge of the effects of patient teaching and non-invasive methods to reduce post-operative pain, stress, and immune function may facilitate postoperative recovery with lower health-care cost. ..
- MEASURING DEPENDENCE AND WITHDRAWAL IN TEEN SMOKERSSuzanne Colby; Fiscal Year: 2001..Thus, it will provide a greater understanding of nicotine withdrawal as a maintaining factor of adolescent smoking, and thereby provide an empirical basis for enhancing smoking cessation approaches for youth. ..
- Oral Health Outcomes of Early Childhood MalnutritionWalter Psoter; Fiscal Year: 2006..Given the universality of PEM pathophysiology, this study's findings will be generalizable to subsets of U.S. children having 9 oral health disparities. ..