- Making a case for domperidone in the treatment of gastrointestinal motility disorders
Department of Medicine and Division of Digestive Disease, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Curr Opin Pharmacol 6:571-6. 2006
There are very few treatment options currently available for patients with gastrointestinal motility disorders, especially patients with gastroparesis...
- Role of serotonin in gastrointestinal motility and irritable bowel syndrome
Department of Super specialty of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
Clin Chim Acta 403:47-55. 2009
..Irritable bowel syndrome (IBS) is a complex disorder that is associated with altered gastrointestinal motility, secretion and sensation...
- Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
Department of Surgery, Shiga University of Medical Science, Otsu, Japan
J Physiol 550:227-40. 2003
..The action of ghrelin to induce fasted motor activity is strongly affected by intragastric pH; low pH inhibits the action...
- Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
Division of Digestive Diseases, Emory University, Atlanta, Georgia
Gastroenterology 143:1006-16.e4. 2012
Altered gastrointestinal motility is associated with significant morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis...
- Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility
Nicolas T Schwarz
Chirurgische Universitätsklinik der Friedrich Wilhelms Universität, Bonn, Germany
Gastroenterology 126:159-69. 2004
..The current objective was to investigate pan-enteric inflammatory molecular and functional motility alterations of the muscularis from the unmanipulated stomach and colon initiated by selective jejunal manipulation...
- Inhibition of macrophage function prevents intestinal inflammation and postoperative ileus in rodents
Department of Surgery, University of Bonn, Bonn 53105, Germany
Gut 56:176-85. 2007
..It was hypothesised that resident macrophages within the intestinal muscularis have an important role in this local inflammation...
- Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum
Kampo and Pharmacognosy Laboratory, R and D Division, Tsumura and Co, Yoshiwara, Ibaraki, Japan
Dig Dis Sci 46:250-6. 2001
The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum...
- Neuroimmune mechanisms in postoperative ileus
G E Boeckxstaens
Department of Gastroenterology, University Hospitals Leuven, Catholic University of Leuven, Leuven, Belgium
Gut 58:1300-11. 2009
..and possibly triggers inflammation at distant untouched areas, leading to a generalised impairment of gastrointestinal motility. Macrophages residing in the muscularis externa and mast cells are the key players in this inflammatory ..
- Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs
X L Jin
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
Dig Dis Sci 46:1171-6. 2001
..medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility. Five mongrel dogs were equipped with four strain-gauge force transducers on the antrum, duodenum, and ..
- Origin, propagation and regional characteristics of porcine gastric slow wave activity determined by high-resolution mapping
J U Egbuji
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
Neurogastroenterol Motil 22:e292-300. 2010
..High-resolution (HR) mapping has recently enabled an accurate description of human and canine gastric slow wave activity, and was employed here to define porcine gastric slow wave activity...
- Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility
Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
World J Gastroenterol 18:2147-60. 2012
- Are interstitial cells of Cajal plurifunction cells in the gut?
Sushil K Sarna
Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, Neuroscience, and Cell Biology, The University of Texas Medical Branch at Gavelston, Galveston, TX 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 294:G372-90. 2008
- Antidepressants attenuate increased susceptibility to colitis in a murine model of depression
Ashwin K Varghese
Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 130:1743-53. 2006
..We also examined whether antidepressant therapy attenuates the increased susceptibility to colitis...
- Gum chewing reduces postoperative ileus? A systematic review and meta-analysis
Emma J Noble
Department of Colorectal Surgery, Derriford Hospital, Derriford Road, Plymouth, PL6 8DH, UK
Int J Surg 7:100-5. 2009
An important cause of delayed recovery from intestinal surgery is postoperative ileus. Gum chewing is a form of sham feeding, which could encourage gastrointestinal motility through cephalic-vagal stimulation.
- Non-peristaltic patterns of motor activity in the guinea-pig proximal colon
G W Hennig
Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia
Neurogastroenterol Motil 22:e207-17. 2010
..Between propulsive periods, complex motor patterns underlie fluid re-absorption and mixing of contents...
- Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease
Dept of Pathophysiology and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Hokkaido, Japan
Am J Physiol Gastrointest Liver Physiol 303:G42-53. 2012
Gastroesophageal reflux disease (GERD) is often associated with decreased upper gastrointestinal motility, and ghrelin is an appetite-stimulating hormone known to increase gastrointestinal motility...
- The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum
Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona UAB, Bellaterra, Barcelona, Spain
Neurogastroenterol Motil 20:1306-16. 2008
..We conclude that H2S strongly inhibits in vitro intestinal and colonic motor patterns. This effect appears to be critically dependent on K channels particularly apamin-sensitive SK channels and glybenclamide-sensitive K (ATP) channels...
- A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus
Sara K Story
Saint George s University School of Medicine, Grenada, West Indies
Dig Surg 26:265-75. 2009
..The causative mechanism is not fully understood and may be multifactorial including disorganized electrical activity, activation of inflammatory mediators and the use of opioid analgesics...
- A comparative study of the effects of electroacupuncture and moxibustion in the gastrointestinal motility of the rat
Division of Chinese Medicine and Acupuncture, Department of Orthopedics and Traumatology, Universidade Federal de Sao Paulo UNIFESP, Rua Vergueiro, 2045, cj 1003, Vila Mariana, 04101 000 São Paulo SP, Brazil
Dig Dis Sci 49:602-10. 2004
..moxibustion) over gastrointestinal motility in rats subjected to restraint-induced stress is not uniform and discuss the different neural pathways ..
- TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
Proc Natl Acad Sci U S A 106:3408-13. 2009
..Taken together, our results indicate that TRPA1 acts as a sensor molecule for EC cells and may regulate gastrointestinal function...
- Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility
M D Gershon
Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
Aliment Pharmacol Ther 20:3-14. 2004
..The observation that molecular defects occur in the human gut in irritable bowel syndrome strengthens the hand of those seeking to legitimize the disease. At least it is not 'all in your head'. The bowel contributes...
- Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition
Department of Surgery, E1, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871 Japan
Am J Surg 192:9-13. 2006
..The purpose of this study was to examine the effects of Dai-kenchu-to on intestinal motility and postoperative QOL of patients...
- Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
FASEB J 18:439-56. 2004
..Defective ghrelin signaling from the stomach could contribute to abnormalities in energy balance, growth, and associated gastrointestinal and neuroendocrine functions...
- Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Exp Neurol 207:4-12. 2007
..They provide insight into the impact of dopaminergic dysfunction on gastrointestinal motility and a benchmark for assessment of other PD model systems.
- Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps
G W Hennig
Department of Human Physiology and Centre for Neuroscience, The Flinders University of South Australia, Adelaide, Australia
Neurogastroenterol Motil 13:483-92. 2001
..6 mm s(-1).Our data revealed that myogenic and neurogenic patterns of propagated contractions in the colon occur in isolated preparations and are involved in emptying the colon...
- Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function
Barun K Choudhury
Div of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, 8 104 Medical Research Bldg, Galveston, TX 77555 1083, USA
Am J Physiol Gastrointest Liver Physiol 296:G1238-47. 2009
..2 channels in circular smooth muscle cells. These findings suggest the potential cellular mechanisms by which heterotypic chronic stress may exacerbate motility dysfunction in patients with irritable bowel syndrome...
- Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome
Michael D Gershon
Department of Anatomy and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
J Clin Gastroenterol 39:S184-93. 2005
..Similar symptoms are seen in transgenic mice that lack SERT. The loss of mucosal SERT may thus contribute to IBS pathogenesis...
- Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
J Smooth Muscle Res 41:163-74. 2005
..It was suggested that ICC have no important role in the ascending and descending neural reflexes in the mouse distal colon, this is in direct contrast to the role of ICC-MY in the ileum...
- Control of gastrointestinal motility by the "gut brain"--the enteric nervous system
Department of Human Biology, Technische Universitat Munchen, Freising Weihenstephan, Germany
J Pediatr Gastroenterol Nutr 41:S4-6. 2005
..This review provides a summary of the ENS circuits that control muscle activity, the main transmitters and neuromodulators involved and the functional implications for the normal and diseased gut...
- Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies
Division of Gastroenterology, Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555 0632, USA
J Cell Mol Med 12:1118-29. 2008
..is to provide a better understanding of the roles of interstitial cells of Cajal (ICC) in regulating gastrointestinal motility by reviewing in vitro and in vivo physiological motility studies...
- Cyclic AMP in rat ileum: evidence for the presence of an extracellular cyclic AMP-adenosine pathway
Maria Cecilia Giron
Department of Pharmacology and Anesthesiology, University of Padova, Padova, Italy
Gastroenterology 134:1116-26. 2008
..Our purpose was to assess the existence of a functional extracellular cAMP-adenosine pathway in intestinal tissue, obtaining evidence for CD73 expression and evaluating the effect of cAMP on ileum motility...
- Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus
N T Schwarz
Department of Medicine Gastroenterology, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Gastroenterology 121:1354-71. 2001
..This study demonstrates a significant role for cyclooxygenase (COX)-2 and prostanoid production as mechanisms for surgically induced postoperative ileus...
- Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps
Rachael R Roberts
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
Am J Physiol Gastrointest Liver Physiol 292:G930-8. 2007
..In mouse, myogenic ripples are the only mechanism available to produce colonic transit at birth. At P6, neural circuits that generate CMMCs are present but are inhibited by tonic activity of nitric oxide. Adult patterns appear by P10...
- Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease
Professor of Gastroenterology, Wolfson Digestive Diseases Centre, Nottingham, UK
Neurogastroenterol Motil 19:25-31. 2007
..While IBS-D is associated with increased 5-HT postprandially, IBS with constipation (IBS-C) is associated with impaired 5-HT response and responds to 5-HT(4) agonists such as Prucalopride and 5-HT(4) partial agonists such as Tegaserod...
- Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at University of California, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 289:G42-53. 2005
- The effects of tramadol and fentanyl on gastrointestinal motility in septic rats
Department of Anesthesiology and Intensive Care, Celal Bayar University, Manisa, Turkey
Anesth Analg 102:876-81. 2006
..This was thought to be the result of an associated endogenic opioid system activation and receptor upregulation in sepsis...
- Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine
P G Dinning
St George Clinical School, University of New South Wales, Australia
Am J Physiol Gastrointest Liver Physiol 300:G577-85. 2011
..Studies of wall motion in isolated preparations, combined with manometry, can assist in interpretation of pressure recordings in vivo...
- Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility
Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona UAB, Bellaterra, Spain
Br J Pharmacol 164:485-98. 2011
..We investigated the effect of D,L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase (CSE), amino-oxyacetic acid (AOAA) and hydroxylamine (HA), inhibitors of cystathionine β-synthase (CBS) on rat colonic motility...
- Stop Fitan: antispasmodic effect of natural extract of chestnut wood in guinea pig ileum and proximal colon smooth muscle
Department of Pharmaceutical Science, University of Bologna, Bologna, Italy
J Med Food 13:1104-10. 2010
..These findings, taken together with the antibacterial, antiviral, and antispasmodic properties of tannins, suggest that the combination of tannins and S. boulardii may be relevant to treat diarrhea by Stop Fitan...
- Central orexin-A increases colonic motility in conscious rats
Department of Regional Medicine and Education, Asahikawa Medical University, Midorigaoka Higashi 2 1 1 1, Asahikawa, Japan
Neurosci Lett 498:143-6. 2011
- Effect of rikkunshito on gastric sensorimotor function under distention
Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Neurogastroenterol Motil 23:323-9, e155-6. 2011
..We conducted a study to verify the hypothesis that rikkunshito improves stress-induced gastric hypersensitivity and/or changes in gastric wall tone...
- Gastrointestinal motility disorders and acupuncture
Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
Auton Neurosci 157:31-7. 2010
..been performed to investigate the effects and mechanisms of acupuncture or electroacupuncture (EA) on gastrointestinal motility and patients with functional gastrointestinal diseases...
- Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats
Department of Anatomy, Sapporo Medical University School of Medicine, Japan
Am J Physiol Gastrointest Liver Physiol 303:G519-28. 2012
..applied the communication box technique to induce psychological stress in rats and then examined their gastrointestinal motility. We measured upper and lower gastrointestinal motility induced by acute and chronic psychological stress ..
- Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour
Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
Stress 13:114-22. 2010
..This study provides evidence of altered colonic function and morphology in two animal models with a heightened response to stress...
- Plasma hormones facilitated the hypermotility of the colon in a chronic stress rat model
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China
PLoS ONE 7:e31774. 2012
..To study the relationship between brain-gut peptides, gastrointestinal hormones and altered motility in a rat model of repetitive water avoidance stress (WAS), which mimics the irritable bowel syndrome (IBS)...
- Neurogenic and myogenic motor patterns of rabbit proximal, mid, and distal colon
P G Dinning
Dept of Human Physiology, School of Medicine, Finders University, Bedford Park, SA 5042, Australia
Am J Physiol Gastrointest Liver Physiol 303:G83-92. 2012
..The regional specificity motor pattern is likely to facilitate orderly transit of colonic content from semi-liquid to solid composition of feces...
- Neuroeffector apparatus in gastrointestinal smooth muscle organs
Kenton M Sanders
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
J Physiol 588:4621-39. 2010
..This review examines the evidence for and against the role of ICC in motor neurotransmission and outlines areas for additional investigation that would help further resolve this controversy...
- Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn's colitis model
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
Am J Physiol Gastrointest Liver Physiol 285:G483-93. 2003
..The dysfunction of the L-type Ca2+ channel may be mediated by NF-kappaB-dependent pathways...
- Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs
Central Research Laboratories, Tsumura and Co, Ibaraki, Japan
Drugs Exp Clin Res 25:211-8. 1999
..These results suggested that Liu-Jun-Zi-Tang promoted gastric adaptive relaxation. This effect might, at least in part, contribute to the symptom relief in patients with functional dyspepsia...
- Effects of isoflurane on gastrointestinal motility after brief exposure in rats
Marc C Torjman
Department of Anesthesiology, Cooper University Hospital, UMDNJ Robert Wood Johnson Medical School, Camden Campus, 401 Haddon Avenue, Education and Research Building, 3rd Floor, Suite 394, Camden, NJ 08103, USA
Int J Pharm 294:65-71. 2005
..This study investigated gastrointestinal motility in rats after brief exposure to Isoflurane (ISO) general anesthesia for orogastric gavage...
- Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects
Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Aliment Pharmacol Ther 27:186-96. 2008
..A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET)...
- Abnormal gastric slow waves in patients with functional dyspepsia assessed by multichannel electrogastrography
Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555, USA
Am J Physiol Gastrointest Liver Physiol 280:G1370-5. 2001
..It was concluded that patients with functional dyspepsia have impaired slow wave propagation and coupling. Multichannel EGG has more information than single-channel EGG for the detection of gastric myoelectrical abnormalities...
- Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus
Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama 338 8570, Japan
Am J Physiol Gastrointest Liver Physiol 302:G1207-15. 2012
..murinus. The results suggest that ghrelin is important for the phase II contraction and that coordination of motilin and ghrelin are necessary to initiate phase III contraction of the MMC...
- Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms
Albert J Bredenoord
Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
Clin Gastroenterol Hepatol 1:264-72. 2003
..The aim of this study was to assess the frequency of disordered gastric accommodation and emptying in patients referred with unexplained upper gastrointestinal symptoms...
- Anisotropic propagation in the small intestine
W J E P Lammers
Department of Physiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
Neurogastroenterol Motil 14:357-64. 2002
..The anisotropic propagation of slow waves may be the result of the interaction between the myenteric layer of interstitial cells of Cajal and their electrotonic connection to both the longitudinal and the circular muscle layer...
- Hydrogen sulfide as a signaling molecule in the enteric nervous system
Department of Cell Biology, Physiology and Immunology, Universitat Auto noma de Barcelona, Barcelona, Spain
Neurogastroenterol Motil 22:1149-53. 2010
..These novel observations extend our understanding of the function of H₂S in the gastrointestinal tract...
- Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
Am J Physiol Gastrointest Liver Physiol 295:G403-11. 2008
- Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats
Institut National de Sante et de Recherche Medicale INSERM, U913, Nantes, France
Gastroenterology 138:1772-82. 2010
..about the environmental and nutritional regulation of the enteric nervous system (ENS), which controls gastrointestinal motility. Short-chain fatty acids (SCFAs) such as butyrate regulate colonic mucosa homeostasis and can modulate ..
- Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China
Neurogastroenterol Motil 22:e162-70. 2010
..This paper aimed to investigate the relationship between up-regulation of L-type calcium channels and altered motility disorder in a rat model of irritable bowel syndrome (IBS)...
- Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function
Institute for Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada
Am J Physiol Gastrointest Liver Physiol 291:G912-27. 2006
..Our data suggest that enteric glia are involved in the modulation of enteric neural circuits underlying the regulation of intestinal motility...
- Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)
Saitama Univ, Japan
Am J Physiol Regul Integr Comp Physiol 299:R1106-13. 2010
..small model animal for in vivo motilin study, and we studied the physiological characteristics of suncus gastrointestinal motility. Strain gauge transducers were implanted on the serosa of the gastric body and duodenum, and we recorded ..
- The herbal medicine Dai-Kenchu-To directly stimulates colonic motility
Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
Surg Today 39:175-7. 2009
..In conclusion, DKT stimulates colonic motility immediately after administration, in the same manner as it does for the upper alimentary tract...
- Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility
Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan
Peptides 32:2348-51. 2011
- Recto-colonic reflex is impaired in patients with irritable bowel syndrome
P P J van der Veek
Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Neurogastroenterol Motil 19:653-9. 2007
..Postprandially this recto-colonic inhibitory reflex is impaired and attenuated in IBS patients compared with controls. These findings point to an altered reflex function in IBS and have implications for pathophysiology and therapy...
- A systematic review of the efficacy of gum chewing for the amelioration of postoperative ileus
S M M de Castro
Academic Medical Center of the University of Amsterdam, Hilversum, The Netherlands
Dig Surg 25:39-45. 2008
..This finding could have a major clinical impact since gum chewing is relatively harmless and cheap while postoperative ileus has a significant impact on healthcare...
- Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice
Wei Qi He
Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
Gastroenterology 135:610-20. 2008
..We generated tamoxifen-inducible and smooth muscle-specific MLCK knockout (KO) mice and provide direct loss-of-function evidence that shows the primary importance of MLCK in phasic smooth muscle contractions...
- A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
Laurie L Baggio
Toronto General Hospital, Banting and Best Diabetes Centre, 200 Elizabeth St, MBRW4R 402, Toronto, Canada
Diabetes 53:2492-500. 2004
..These findings illustrate that peripheral administration of a larger peptide-albumin recombinant protein mimics GLP-1R-dependent activation of central and peripheral pathways regulating energy intake and glucose homeostasis in vivo...
- Neurohumoral control of gastrointestinal motility
M B Hansen
Department of Surgical Gastroenterology K, Bispebjerg University Hospital of Copenhagen, NV, Denmark
Physiol Res 52:1-30. 2003
Neurohumoral substances and their receptors play a major part in the complex regulation of gastrointestinal motility and have therefore been the predominant targets for drug development...
- Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced?
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
J Smooth Muscle Res 43:43-54. 2007
..In the present review, we discuss the functional failure of smooth muscle cells, including changes in the activity of muscarinic receptors, ion channels and the endogenous myosin phosphatase inhibitor CPI-17...
- Peripheral motor action of glucagon-like peptide-1 through enteric neuronal receptors
Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, 90128 Palermo, Italy
Neurogastroenterol Motil 22:664-e203. 2010
..Glucagon-like peptide-1 exerts inhibitory effects on gastrointestinal motility through vagal afferents and central nervous mechanisms; however, no data is available about a direct ..
- Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs
Pharmacology Laboratories, Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
Eur J Pharmacol 617:124-9. 2009
..Moreover, we examined the effect of AITC on gastrointestinal motility in dogs...
- Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study
M W Buchler
Department of Surgery, University of Heidelberg, Heidelberg, Germany
Aliment Pharmacol Ther 28:312-25. 2008
..Post-operative ileus (POI) affects most patients undergoing abdominal surgery...
- Current therapies to shorten postoperative ileus
Michael D Johnson
Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Cleve Clin J Med 76:641-8. 2009
..To shorten the duration of postoperative ileus, we may need to establish standard plans of care that favor earlier feeding, use of nasogastric tubes only on a selective basis, and prokinetic drugs as needed...
- Damage of the interstitial cells of Cajal and myenteric neurons causing ileus in acute necrotizing pancreatitis rats
Laboratory of Stress Research, Department of Internal Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China
Surgery 149:262-75. 2011
- Diabetes and the enteric nervous system
Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
Neurogastroenterol Motil 19:951-60. 2007
..Recent research on the nerve-immune interactions demonstrates inflammation-associated neurodegeneration which can lead to motility related problems in diabetes...
- Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents
Center for Ulcer Research and Education Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Gastroenterology 140:1586-96.e6. 2011
..Corticotropin-releasing factor receptor-1 (CRF(1)) mediates the stress-induced colonic motor activity. Less is known about the role of CRF(2) in the colonic response to stress...
- Changes in brain G proteins and colonic sympathetic neural signaling in chronic-acute combined stress rat model of irritable bowel syndrome (IBS)
Peking Union Medical College Hospital corrected
Transl Res 152:283-9. 2008
..We showed that exposure to either AS or CAS would cause the increase of secretion, motility, and sensation, but the change of protein expression in brain-gut axis was different. It may be responsible for the pathogenesis of IBS...
- The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns
Department of Pediatrics, University of Bari Policlinico, Bari, Italy
J Pediatr 152:801-6. 2008
To investigate the effect of dietary supplementation with a probiotic on feeding tolerance and gastrointestinal motility in healthy formula-fed preterm infants.
- A critical review of auscultating bowel sounds
University of Brighton, Brighton, UK
Br J Nurs 18:1125-9. 2009
- GLP-1 regulates gastroduodenal motility involving cholinergic pathways
Department of Internal Medicine II, Ludwig Maximilians University, Munich, Germany
Neurogastroenterol Motil 21:609-18, e21-2. 2009
..Cholinergic mechanisms mediate the effects of GLP-1 on postprandial gastric accommodation but not on antro-pyloro-duodenal motility. GLP-1 reduces fasting and postprandial glycaemia, in part by reducing glucagon secretion...
- Gut motor function: immunological control in enteric infection and inflammation
W I Khan
Intestinal Diseases Research Program, Division of Gastroenterology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5 Canada
Clin Exp Immunol 143:389-97. 2006
..valuable information on the immunological control of gut motor function and its role in host defence in enteric infection, but also provide a basis for understanding pathophysiology of gastrointestinal motility disorders such as in IBS.
- Review article: molecular, pathological and therapeutic features of human enteric neuropathies
G Di Nardo
Department of Pediatrics, Pediatric Gastroenterology Unit, University of Rome La Sapienza, Rome, Italy
Aliment Pharmacol Ther 28:25-42. 2008
..information has been gathered on the functional organization of enteric neuronal circuitries regulating gastrointestinal motility. However, little is known about the neuropathophysiological mechanisms underlying gastrointestinal motor ..
- Antibodies against gonadotropin-releasing hormone (GnRH) and destruction of enteric neurons in 3 patients suffering from gastrointestinal dysfunction
Department of Clinical Sciences, Gastroenterology Division, Skane University Hospital, Malmo, Lund University, Lund, Sweden
BMC Gastroenterol 10:48. 2010
..The aim of this study was to examine the presence of such antibodies in patients with dysmotility not subjected to GnRH treatment and study the anti-GnRH antibody effect on enteric neurons viability in vitro...
- Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics
Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
Aliment Pharmacol Ther 19:379-90. 2004
..A knowledge of central and peripheral D2 receptor pharmacology can help the clinician to choose between the antidopaminergic prokinetics to obtain a more favourable risk/benefit ratio...
- Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men
Amelia N Pilichiewicz
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide SA 5000, Australia
Am J Physiol Endocrinol Metab 293:E743-53. 2007
..These observations have implications for strategies to minimize postprandial glycemic excursions in type 2 diabetes...
- Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway
Xiao Yu Tian
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR
Brain Res 1088:101-8. 2006
..Thus, it can be concluded that EA attenuates behavioral hyperalgesia and stress-induced colonic motor dysfunction in CVH rats via serotonergic pathway...
- Mechanisms of polymicrobial sepsis-induced ileus
Department of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
Am J Physiol Gastrointest Liver Physiol 287:G685-94. 2004
- 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Yamashina, Japan
Dig Dis Sci 47:894-904. 2002
- Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
Department of Internal Medicine II, Clinical Research Unit, Ludwig Maximilians University, Marchioninistr 15, Munich 81377, Germany
Gut 55:243-51. 2006
..Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying...
- Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice
Department of Pharmaceutical Sciences, University of Salerno, via Ponte Don Melillo 84084 Fisciano (SA, Italy
Br J Pharmacol 134:945-50. 2001
..The decreased levels of PEA in croton oil-treated might contribute, at least in part, to the exaggerated transit observed during chronic intestinal inflammation...
- Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice
Zhi Shan Li
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Neurosci 26:2798-807. 2006
..Because motility is abnormal when D2 is absent, the net inhibitory DA effect on motility is physiologically significant. The early expression of DA receptors is also consistent with the possibility that DA affects ENS development...
- Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine
Daniel P Poole
Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville 3010, Australia
Cell Tissue Res 325:413-22. 2006
..Expression of the protein and mRNA has been confirmed in extracts containing enteric neurons. The observations suggest that one site of action of 5-HT4 receptor agonists is the intrinsic primary afferent neurons...
- Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity
Department of Medicine, Division of Hepatology and Gastroenterology, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
Dig Dis 19:201-11. 2001
..g. the amygdala. Stress-induced activation or sensitization of mucosal mast cells in the GI tract seem to be involved in stress-associated alterations of visceral sensitivity...
- Dietary herb extract dai-kenchu-to ameliorates constipation in parkinsonian patients (Parkinson's disease and multiple system atrophy)
Mov Disord 20:261-2. 2005
- Mechanisms and treatment of postoperative ileus
University of California at Sanf Francisco East Bay, Oakland, USA
Arch Surg 138:206-14. 2003
..To review the pathogenesis and treatment of postoperative ileus...
- Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation
Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Physiol Gastrointest Liver Physiol 285:G577-85. 2003
..6 ml. However, responses reached a plateau at a distending volume >0.8 ml. We concluded that enhanced contraction of the antrum can activate vagal afferents signaling to the CNS...
- Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons
Department of Medicine, Gastroenterology Unit, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
Regul Pept 121:25-30. 2004
- Effect of Dai-kenchu-to on gastrointestinal motility based on differences in the site and timing of administration
Department of Surgery, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
Dig Dis Sci 52:2684-94. 2007
The purpose of this study was to investigate the effects of the herbal medicine dai-kenchu-to on gastrointestinal motility based on differences in the administration site and timing...
- High-definition spatiotemporal mapping of contractile activity in the isolated proximal colon of the rabbit
Roger G Lentle
Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand
J Comp Physiol B 178:257-68. 2008
..The orad movement of watery fluid was possibly due to ripples in the absence of haustra...
- Interstitial cells of Cajal and adaptive relaxation in the mouse stomach
Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Physiol Gastrointest Liver Physiol 291:G1129-36. 2006
..ICC-IM may be involved in regulation of (distention-induced) myogenic tone...
- Melatonin and serotonin effects on gastrointestinal motility
P J Thor
Department of Pathophysiology, Medical College, Jagiellonian University, Czysta 18 str, Cracow, Poland
J Physiol Pharmacol 58:97-103. 2007
..Since of its unique properties M could be considered for prevention or treatment of colorectal cancer, ulcerative colitis, gastric ulcers and irritable bowel syndrome...