gastrointestinal motility

Summary

Top Publications

  1. ncbi Making a case for domperidone in the treatment of gastrointestinal motility disorders
    Naveed Ahmad
    Department of Medicine and Division of Digestive Disease, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Curr Opin Pharmacol 6:571-6. 2006
  2. ncbi Role of serotonin in gastrointestinal motility and irritable bowel syndrome
    Arbab Sikander
    Department of Super specialty of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
    Clin Chim Acta 403:47-55. 2009
  3. pmc Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    Kazunori Fujino
    Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    J Physiol 550:227-40. 2003
  4. pmc Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
    Mallappa Anitha
    Division of Digestive Diseases, Emory University, Atlanta, Georgia
    Gastroenterology 143:1006-16.e4. 2012
  5. ncbi Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility
    Nicolas T Schwarz
    Chirurgische Universitätsklinik der Friedrich Wilhelms Universität, Bonn, Germany
    Gastroenterology 126:159-69. 2004
  6. pmc Inhibition of macrophage function prevents intestinal inflammation and postoperative ileus in rodents
    Sven Wehner
    Department of Surgery, University of Bonn, Bonn 53105, Germany
    Gut 56:176-85. 2007
  7. ncbi Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum
    K Satoh
    Kampo and Pharmacognosy Laboratory, R and D Division, Tsumura and Co, Yoshiwara, Ibaraki, Japan
    Dig Dis Sci 46:250-6. 2001
  8. ncbi Neuroimmune mechanisms in postoperative ileus
    G E Boeckxstaens
    Department of Gastroenterology, University Hospitals Leuven, Catholic University of Leuven, Leuven, Belgium
    Gut 58:1300-11. 2009
  9. ncbi Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs
    X L Jin
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dig Dis Sci 46:1171-6. 2001
  10. pmc Origin, propagation and regional characteristics of porcine gastric slow wave activity determined by high-resolution mapping
    J U Egbuji
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Neurogastroenterol Motil 22:e292-300. 2010

Detail Information

Publications388 found, 100 shown here

  1. ncbi Making a case for domperidone in the treatment of gastrointestinal motility disorders
    Naveed Ahmad
    Department of Medicine and Division of Digestive Disease, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Curr Opin Pharmacol 6:571-6. 2006
    There are very few treatment options currently available for patients with gastrointestinal motility disorders, especially patients with gastroparesis...
  2. ncbi Role of serotonin in gastrointestinal motility and irritable bowel syndrome
    Arbab Sikander
    Department of Super specialty of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
    Clin Chim Acta 403:47-55. 2009
    ..Irritable bowel syndrome (IBS) is a complex disorder that is associated with altered gastrointestinal motility, secretion and sensation...
  3. pmc Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    Kazunori Fujino
    Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    J Physiol 550:227-40. 2003
    ..The action of ghrelin to induce fasted motor activity is strongly affected by intragastric pH; low pH inhibits the action...
  4. pmc Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
    Mallappa Anitha
    Division of Digestive Diseases, Emory University, Atlanta, Georgia
    Gastroenterology 143:1006-16.e4. 2012
    Altered gastrointestinal motility is associated with significant morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis...
  5. ncbi Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility
    Nicolas T Schwarz
    Chirurgische Universitätsklinik der Friedrich Wilhelms Universität, Bonn, Germany
    Gastroenterology 126:159-69. 2004
    ..The current objective was to investigate pan-enteric inflammatory molecular and functional motility alterations of the muscularis from the unmanipulated stomach and colon initiated by selective jejunal manipulation...
  6. pmc Inhibition of macrophage function prevents intestinal inflammation and postoperative ileus in rodents
    Sven Wehner
    Department of Surgery, University of Bonn, Bonn 53105, Germany
    Gut 56:176-85. 2007
    ..It was hypothesised that resident macrophages within the intestinal muscularis have an important role in this local inflammation...
  7. ncbi Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum
    K Satoh
    Kampo and Pharmacognosy Laboratory, R and D Division, Tsumura and Co, Yoshiwara, Ibaraki, Japan
    Dig Dis Sci 46:250-6. 2001
    The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum...
  8. ncbi Neuroimmune mechanisms in postoperative ileus
    G E Boeckxstaens
    Department of Gastroenterology, University Hospitals Leuven, Catholic University of Leuven, Leuven, Belgium
    Gut 58:1300-11. 2009
    ..and possibly triggers inflammation at distant untouched areas, leading to a generalised impairment of gastrointestinal motility. Macrophages residing in the muscularis externa and mast cells are the key players in this inflammatory ..
  9. ncbi Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs
    X L Jin
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dig Dis Sci 46:1171-6. 2001
    ..medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility. Five mongrel dogs were equipped with four strain-gauge force transducers on the antrum, duodenum, and ..
  10. pmc Origin, propagation and regional characteristics of porcine gastric slow wave activity determined by high-resolution mapping
    J U Egbuji
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Neurogastroenterol Motil 22:e292-300. 2010
    ..High-resolution (HR) mapping has recently enabled an accurate description of human and canine gastric slow wave activity, and was employed here to define porcine gastric slow wave activity...
  11. pmc Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility
    Koji Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    World J Gastroenterol 18:2147-60. 2012
    ....
  12. ncbi Are interstitial cells of Cajal plurifunction cells in the gut?
    Sushil K Sarna
    Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, Neuroscience, and Cell Biology, The University of Texas Medical Branch at Gavelston, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 294:G372-90. 2008
    ....
  13. ncbi Antidepressants attenuate increased susceptibility to colitis in a murine model of depression
    Ashwin K Varghese
    Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1743-53. 2006
    ..We also examined whether antidepressant therapy attenuates the increased susceptibility to colitis...
  14. ncbi Gum chewing reduces postoperative ileus? A systematic review and meta-analysis
    Emma J Noble
    Department of Colorectal Surgery, Derriford Hospital, Derriford Road, Plymouth, PL6 8DH, UK
    Int J Surg 7:100-5. 2009
    An important cause of delayed recovery from intestinal surgery is postoperative ileus. Gum chewing is a form of sham feeding, which could encourage gastrointestinal motility through cephalic-vagal stimulation.
  15. ncbi Non-peristaltic patterns of motor activity in the guinea-pig proximal colon
    G W Hennig
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia
    Neurogastroenterol Motil 22:e207-17. 2010
    ..Between propulsive periods, complex motor patterns underlie fluid re-absorption and mixing of contents...
  16. pmc Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease
    Miwa Nahata
    Dept of Pathophysiology and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Hokkaido, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G42-53. 2012
    Gastroesophageal reflux disease (GERD) is often associated with decreased upper gastrointestinal motility, and ghrelin is an appetite-stimulating hormone known to increase gastrointestinal motility...
  17. ncbi The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum
    D Gallego
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona UAB, Bellaterra, Barcelona, Spain
    Neurogastroenterol Motil 20:1306-16. 2008
    ..We conclude that H2S strongly inhibits in vitro intestinal and colonic motor patterns. This effect appears to be critically dependent on K channels particularly apamin-sensitive SK channels and glybenclamide-sensitive K (ATP) channels...
  18. ncbi A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus
    Sara K Story
    Saint George s University School of Medicine, Grenada, West Indies
    Dig Surg 26:265-75. 2009
    ..The causative mechanism is not fully understood and may be multifactorial including disorganized electrical activity, activation of inflammatory mediators and the use of opioid analgesics...
  19. ncbi A comparative study of the effects of electroacupuncture and moxibustion in the gastrointestinal motility of the rat
    Angela Tabosa
    Division of Chinese Medicine and Acupuncture, Department of Orthopedics and Traumatology, Universidade Federal de Sao Paulo UNIFESP, Rua Vergueiro, 2045, cj 1003, Vila Mariana, 04101 000 São Paulo SP, Brazil
    Dig Dis Sci 49:602-10. 2004
    ..moxibustion) over gastrointestinal motility in rats subjected to restraint-induced stress is not uniform and discuss the different neural pathways ..
  20. pmc TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
    Katsura Nozawa
    Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
    Proc Natl Acad Sci U S A 106:3408-13. 2009
    ..Taken together, our results indicate that TRPA1 acts as a sensor molecule for EC cells and may regulate gastrointestinal function...
  21. ncbi Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    Aliment Pharmacol Ther 20:3-14. 2004
    ..The observation that molecular defects occur in the human gut in irritable bowel syndrome strengthens the hand of those seeking to legitimize the disease. At least it is not 'all in your head'. The bowel contributes...
  22. ncbi Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition
    Shunji Endo
    Department of Surgery, E1, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871 Japan
    Am J Surg 192:9-13. 2006
    ..The purpose of this study was to examine the effects of Dai-kenchu-to on intestinal motility and postoperative QOL of patients...
  23. ncbi Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
    ..Defective ghrelin signaling from the stomach could contribute to abnormalities in energy balance, growth, and associated gastrointestinal and neuroendocrine functions...
  24. pmc Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
    Grant Anderson
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 207:4-12. 2007
    ..They provide insight into the impact of dopaminergic dysfunction on gastrointestinal motility and a benchmark for assessment of other PD model systems.
  25. ncbi Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps
    G W Hennig
    Department of Human Physiology and Centre for Neuroscience, The Flinders University of South Australia, Adelaide, Australia
    Neurogastroenterol Motil 13:483-92. 2001
    ..6 mm s(-1).Our data revealed that myogenic and neurogenic patterns of propagated contractions in the colon occur in isolated preparations and are involved in emptying the colon...
  26. pmc Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function
    Barun K Choudhury
    Div of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, 8 104 Medical Research Bldg, Galveston, TX 77555 1083, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1238-47. 2009
    ..2 channels in circular smooth muscle cells. These findings suggest the potential cellular mechanisms by which heterotypic chronic stress may exacerbate motility dysfunction in patients with irritable bowel syndrome...
  27. ncbi Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome
    Michael D Gershon
    Department of Anatomy and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
    J Clin Gastroenterol 39:S184-93. 2005
    ..Similar symptoms are seen in transgenic mice that lack SERT. The loss of mucosal SERT may thus contribute to IBS pathogenesis...
  28. ncbi Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal
    Yutaka Okishio
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
    J Smooth Muscle Res 41:163-74. 2005
    ..It was suggested that ICC have no important role in the ascending and descending neural reflexes in the mouse distal colon, this is in direct contrast to the role of ICC-MY in the ileum...
  29. ncbi Control of gastrointestinal motility by the "gut brain"--the enteric nervous system
    Michael Schemann
    Department of Human Biology, Technische Universitat Munchen, Freising Weihenstephan, Germany
    J Pediatr Gastroenterol Nutr 41:S4-6. 2005
    ..This review provides a summary of the ENS circuits that control muscle activity, the main transmitters and neuromodulators involved and the functional implications for the normal and diseased gut...
  30. ncbi Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies
    Jieyun Yin
    Division of Gastroenterology, Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555 0632, USA
    J Cell Mol Med 12:1118-29. 2008
    ..is to provide a better understanding of the roles of interstitial cells of Cajal (ICC) in regulating gastrointestinal motility by reviewing in vitro and in vivo physiological motility studies...
  31. ncbi Cyclic AMP in rat ileum: evidence for the presence of an extracellular cyclic AMP-adenosine pathway
    Maria Cecilia Giron
    Department of Pharmacology and Anesthesiology, University of Padova, Padova, Italy
    Gastroenterology 134:1116-26. 2008
    ..Our purpose was to assess the existence of a functional extracellular cAMP-adenosine pathway in intestinal tissue, obtaining evidence for CD73 expression and evaluating the effect of cAMP on ileum motility...
  32. ncbi Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus
    N T Schwarz
    Department of Medicine Gastroenterology, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Gastroenterology 121:1354-71. 2001
    ..This study demonstrates a significant role for cyclooxygenase (COX)-2 and prostanoid production as mechanisms for surgically induced postoperative ileus...
  33. ncbi Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps
    Rachael R Roberts
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G930-8. 2007
    ..In mouse, myogenic ripples are the only mechanism available to produce colonic transit at birth. At P6, neural circuits that generate CMMCs are present but are inhibited by tonic activity of nitric oxide. Adult patterns appear by P10...
  34. ncbi Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease
    R Spiller
    Professor of Gastroenterology, Wolfson Digestive Diseases Centre, Nottingham, UK
    Neurogastroenterol Motil 19:25-31. 2007
    ..While IBS-D is associated with increased 5-HT postprandially, IBS with constipation (IBS-C) is associated with impaired 5-HT response and responds to 5-HT(4) agonists such as Prucalopride and 5-HT(4) partial agonists such as Tegaserod...
  35. ncbi Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
    Sylvie Bradesi
    Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at University of California, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 289:G42-53. 2005
    ....
  36. ncbi The effects of tramadol and fentanyl on gastrointestinal motility in septic rats
    Ismet Topcu
    Department of Anesthesiology and Intensive Care, Celal Bayar University, Manisa, Turkey
    Anesth Analg 102:876-81. 2006
    ..This was thought to be the result of an associated endogenic opioid system activation and receptor upregulation in sepsis...
  37. ncbi Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine
    P G Dinning
    St George Clinical School, University of New South Wales, Australia
    Am J Physiol Gastrointest Liver Physiol 300:G577-85. 2011
    ..Studies of wall motion in isolated preparations, combined with manometry, can assist in interpretation of pressure recordings in vivo...
  38. pmc Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility
    V Gil
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona UAB, Bellaterra, Spain
    Br J Pharmacol 164:485-98. 2011
    ..We investigated the effect of D,L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase (CSE), amino-oxyacetic acid (AOAA) and hydroxylamine (HA), inhibitors of cystathionine β-synthase (CBS) on rat colonic motility...
  39. ncbi Stop Fitan: antispasmodic effect of natural extract of chestnut wood in guinea pig ileum and proximal colon smooth muscle
    Roberta Budriesi
    Department of Pharmaceutical Science, University of Bologna, Bologna, Italy
    J Med Food 13:1104-10. 2010
    ..These findings, taken together with the antibacterial, antiviral, and antispasmodic properties of tannins, suggest that the combination of tannins and S. boulardii may be relevant to treat diarrhea by Stop Fitan...
  40. ncbi Central orexin-A increases colonic motility in conscious rats
    Tsukasa Nozu
    Department of Regional Medicine and Education, Asahikawa Medical University, Midorigaoka Higashi 2 1 1 1, Asahikawa, Japan
    Neurosci Lett 498:143-6. 2011
    ....
  41. ncbi Effect of rikkunshito on gastric sensorimotor function under distention
    M Shiratori
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurogastroenterol Motil 23:323-9, e155-6. 2011
    ..We conducted a study to verify the hypothesis that rikkunshito improves stress-induced gastric hypersensitivity and/or changes in gastric wall tone...
  42. pmc Gastrointestinal motility disorders and acupuncture
    Jieyun Yin
    Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
    Auton Neurosci 157:31-7. 2010
    ..been performed to investigate the effects and mechanisms of acupuncture or electroacupuncture (EA) on gastrointestinal motility and patients with functional gastrointestinal diseases...
  43. ncbi Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats
    Koji Ataka
    Department of Anatomy, Sapporo Medical University School of Medicine, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G519-28. 2012
    ..applied the communication box technique to induce psychological stress in rats and then examined their gastrointestinal motility. We measured upper and lower gastrointestinal motility induced by acute and chronic psychological stress ..
  44. ncbi Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour
    Dervla O'Malley
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Stress 13:114-22. 2010
    ..This study provides evidence of altered colonic function and morphology in two animal models with a heightened response to stress...
  45. pmc Plasma hormones facilitated the hypermotility of the colon in a chronic stress rat model
    Chengbai Liang
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China
    PLoS ONE 7:e31774. 2012
    ..To study the relationship between brain-gut peptides, gastrointestinal hormones and altered motility in a rat model of repetitive water avoidance stress (WAS), which mimics the irritable bowel syndrome (IBS)...
  46. ncbi Neurogenic and myogenic motor patterns of rabbit proximal, mid, and distal colon
    P G Dinning
    Dept of Human Physiology, School of Medicine, Finders University, Bedford Park, SA 5042, Australia
    Am J Physiol Gastrointest Liver Physiol 303:G83-92. 2012
    ..The regional specificity motor pattern is likely to facilitate orderly transit of colonic content from semi-liquid to solid composition of feces...
  47. pmc Neuroeffector apparatus in gastrointestinal smooth muscle organs
    Kenton M Sanders
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 588:4621-39. 2010
    ..This review examines the evidence for and against the role of ICC in motor neurotransmission and outlines areas for additional investigation that would help further resolve this controversy...
  48. ncbi Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn's colitis model
    Kazuya Kinoshita
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G483-93. 2003
    ..The dysfunction of the L-type Ca2+ channel may be mediated by NF-kappaB-dependent pathways...
  49. ncbi Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs
    T Hayakawa
    Central Research Laboratories, Tsumura and Co, Ibaraki, Japan
    Drugs Exp Clin Res 25:211-8. 1999
    ..These results suggested that Liu-Jun-Zi-Tang promoted gastric adaptive relaxation. This effect might, at least in part, contribute to the symptom relief in patients with functional dyspepsia...
  50. ncbi Effects of isoflurane on gastrointestinal motility after brief exposure in rats
    Marc C Torjman
    Department of Anesthesiology, Cooper University Hospital, UMDNJ Robert Wood Johnson Medical School, Camden Campus, 401 Haddon Avenue, Education and Research Building, 3rd Floor, Suite 394, Camden, NJ 08103, USA
    Int J Pharm 294:65-71. 2005
    ..This study investigated gastrointestinal motility in rats after brief exposure to Isoflurane (ISO) general anesthesia for orogastric gavage...
  51. ncbi Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects
    B Kuo
    Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Aliment Pharmacol Ther 27:186-96. 2008
    ..A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET)...
  52. ncbi Abnormal gastric slow waves in patients with functional dyspepsia assessed by multichannel electrogastrography
    X Lin
    Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1370-5. 2001
    ..It was concluded that patients with functional dyspepsia have impaired slow wave propagation and coupling. Multichannel EGG has more information than single-channel EGG for the detection of gastric myoelectrical abnormalities...
  53. ncbi Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus
    Anupom Mondal
    Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama 338 8570, Japan
    Am J Physiol Gastrointest Liver Physiol 302:G1207-15. 2012
    ..murinus. The results suggest that ghrelin is important for the phase II contraction and that coordination of motilin and ghrelin are necessary to initiate phase III contraction of the MMC...
  54. ncbi Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms
    Albert J Bredenoord
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 1:264-72. 2003
    ..The aim of this study was to assess the frequency of disordered gastric accommodation and emptying in patients referred with unexplained upper gastrointestinal symptoms...
  55. ncbi Anisotropic propagation in the small intestine
    W J E P Lammers
    Department of Physiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Neurogastroenterol Motil 14:357-64. 2002
    ..The anisotropic propagation of slow waves may be the result of the interaction between the myenteric layer of interstitial cells of Cajal and their electrotonic connection to both the longitudinal and the circular muscle layer...
  56. ncbi Hydrogen sulfide as a signaling molecule in the enteric nervous system
    M Jimenez
    Department of Cell Biology, Physiology and Immunology, Universitat Auto noma de Barcelona, Barcelona, Spain
    Neurogastroenterol Motil 22:1149-53. 2010
    ..These novel observations extend our understanding of the function of H₂S in the gastrointestinal tract...
  57. ncbi Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats
    Hiroshi Taniguchi
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Am J Physiol Gastrointest Liver Physiol 295:G403-11. 2008
    ....
  58. ncbi Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats
    Rodolphe Soret
    Institut National de Sante et de Recherche Medicale INSERM, U913, Nantes, France
    Gastroenterology 138:1772-82. 2010
    ..about the environmental and nutritional regulation of the enteric nervous system (ENS), which controls gastrointestinal motility. Short-chain fatty acids (SCFAs) such as butyrate regulate colonic mucosa homeostasis and can modulate ..
  59. ncbi Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells
    M Zhang
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China
    Neurogastroenterol Motil 22:e162-70. 2010
    ..This paper aimed to investigate the relationship between up-regulation of L-type calcium channels and altered motility disorder in a rat model of irritable bowel syndrome (IBS)...
  60. ncbi Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function
    Yasmin Nasser
    Institute for Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 291:G912-27. 2006
    ..Our data suggest that enteric glia are involved in the modulation of enteric neural circuits underlying the regulation of intestinal motility...
  61. ncbi Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)
    Satoshi Sakahara
    Saitama Univ, Japan
    Am J Physiol Regul Integr Comp Physiol 299:R1106-13. 2010
    ..small model animal for in vivo motilin study, and we studied the physiological characteristics of suncus gastrointestinal motility. Strain gauge transducers were implanted on the serosa of the gastric body and duodenum, and we recorded ..
  62. ncbi The herbal medicine Dai-Kenchu-To directly stimulates colonic motility
    Hidejiro Kawahara
    Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Surg Today 39:175-7. 2009
    ..In conclusion, DKT stimulates colonic motility immediately after administration, in the same manner as it does for the upper alimentary tract...
  63. ncbi Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility
    Mineko Fujimiya
    Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan
    Peptides 32:2348-51. 2011
    ....
  64. ncbi Recto-colonic reflex is impaired in patients with irritable bowel syndrome
    P P J van der Veek
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Neurogastroenterol Motil 19:653-9. 2007
    ..Postprandially this recto-colonic inhibitory reflex is impaired and attenuated in IBS patients compared with controls. These findings point to an altered reflex function in IBS and have implications for pathophysiology and therapy...
  65. ncbi A systematic review of the efficacy of gum chewing for the amelioration of postoperative ileus
    S M M de Castro
    Academic Medical Center of the University of Amsterdam, Hilversum, The Netherlands
    Dig Surg 25:39-45. 2008
    ..This finding could have a major clinical impact since gum chewing is relatively harmless and cheap while postoperative ileus has a significant impact on healthcare...
  66. pmc Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice
    Wei Qi He
    Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    Gastroenterology 135:610-20. 2008
    ..We generated tamoxifen-inducible and smooth muscle-specific MLCK knockout (KO) mice and provide direct loss-of-function evidence that shows the primary importance of MLCK in phasic smooth muscle contractions...
  67. ncbi A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
    Laurie L Baggio
    Toronto General Hospital, Banting and Best Diabetes Centre, 200 Elizabeth St, MBRW4R 402, Toronto, Canada
    Diabetes 53:2492-500. 2004
    ..These findings illustrate that peripheral administration of a larger peptide-albumin recombinant protein mimics GLP-1R-dependent activation of central and peripheral pathways regulating energy intake and glucose homeostasis in vivo...
  68. ncbi Neurohumoral control of gastrointestinal motility
    M B Hansen
    Department of Surgical Gastroenterology K, Bispebjerg University Hospital of Copenhagen, NV, Denmark
    Physiol Res 52:1-30. 2003
    Neurohumoral substances and their receptors play a major part in the complex regulation of gastrointestinal motility and have therefore been the predominant targets for drug development...
  69. ncbi Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced?
    Takashi Ohama
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Smooth Muscle Res 43:43-54. 2007
    ..In the present review, we discuss the functional failure of smooth muscle cells, including changes in the activity of muscarinic receptors, ion channels and the endogenous myosin phosphatase inhibitor CPI-17...
  70. ncbi Peripheral motor action of glucagon-like peptide-1 through enteric neuronal receptors
    A Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, 90128 Palermo, Italy
    Neurogastroenterol Motil 22:664-e203. 2010
    ..Glucagon-like peptide-1 exerts inhibitory effects on gastrointestinal motility through vagal afferents and central nervous mechanisms; however, no data is available about a direct ..
  71. ncbi Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs
    Hitoshi Doihara
    Pharmacology Laboratories, Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    Eur J Pharmacol 617:124-9. 2009
    ..Moreover, we examined the effect of AITC on gastrointestinal motility in dogs...
  72. ncbi Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study
    M W Buchler
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Aliment Pharmacol Ther 28:312-25. 2008
    ..Post-operative ileus (POI) affects most patients undergoing abdominal surgery...
  73. ncbi Current therapies to shorten postoperative ileus
    Michael D Johnson
    Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:641-8. 2009
    ..To shorten the duration of postoperative ileus, we may need to establish standard plans of care that favor earlier feeding, use of nasogastric tubes only on a selective basis, and prokinetic drugs as needed...
  74. ncbi Damage of the interstitial cells of Cajal and myenteric neurons causing ileus in acute necrotizing pancreatitis rats
    Hui Zhou
    Laboratory of Stress Research, Department of Internal Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China
    Surgery 149:262-75. 2011
    ....
  75. pmc Diabetes and the enteric nervous system
    B Chandrasekharan
    Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Neurogastroenterol Motil 19:951-60. 2007
    ..Recent research on the nerve-immune interactions demonstrates inflammation-associated neurodegeneration which can lead to motility related problems in diabetes...
  76. pmc Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents
    Guillaume Gourcerol
    Center for Ulcer Research and Education Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Gastroenterology 140:1586-96.e6. 2011
    ..Corticotropin-releasing factor receptor-1 (CRF(1)) mediates the stress-induced colonic motor activity. Less is known about the role of CRF(2) in the colonic response to stress...
  77. ncbi Changes in brain G proteins and colonic sympathetic neural signaling in chronic-acute combined stress rat model of irritable bowel syndrome (IBS)
    Ning Zou
    Peking Union Medical College Hospital corrected
    Transl Res 152:283-9. 2008
    ..We showed that exposure to either AS or CAS would cause the increase of secretion, motility, and sensation, but the change of protein expression in brain-gut axis was different. It may be responsible for the pathogenesis of IBS...
  78. ncbi The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns
    Flavia Indrio
    Department of Pediatrics, University of Bari Policlinico, Bari, Italy
    J Pediatr 152:801-6. 2008
    To investigate the effect of dietary supplementation with a probiotic on feeding tolerance and gastrointestinal motility in healthy formula-fed preterm infants.
  79. ncbi A critical review of auscultating bowel sounds
    Heather Baid
    University of Brighton, Brighton, UK
    Br J Nurs 18:1125-9. 2009
    ....
  80. ncbi GLP-1 regulates gastroduodenal motility involving cholinergic pathways
    J Schirra
    Department of Internal Medicine II, Ludwig Maximilians University, Munich, Germany
    Neurogastroenterol Motil 21:609-18, e21-2. 2009
    ..Cholinergic mechanisms mediate the effects of GLP-1 on postprandial gastric accommodation but not on antro-pyloro-duodenal motility. GLP-1 reduces fasting and postprandial glycaemia, in part by reducing glucagon secretion...
  81. pmc Gut motor function: immunological control in enteric infection and inflammation
    W I Khan
    Intestinal Diseases Research Program, Division of Gastroenterology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5 Canada
    Clin Exp Immunol 143:389-97. 2006
    ..valuable information on the immunological control of gut motor function and its role in host defence in enteric infection, but also provide a basis for understanding pathophysiology of gastrointestinal motility disorders such as in IBS.
  82. ncbi Review article: molecular, pathological and therapeutic features of human enteric neuropathies
    G Di Nardo
    Department of Pediatrics, Pediatric Gastroenterology Unit, University of Rome La Sapienza, Rome, Italy
    Aliment Pharmacol Ther 28:25-42. 2008
    ..information has been gathered on the functional organization of enteric neuronal circuitries regulating gastrointestinal motility. However, little is known about the neuropathophysiological mechanisms underlying gastrointestinal motor ..
  83. pmc Antibodies against gonadotropin-releasing hormone (GnRH) and destruction of enteric neurons in 3 patients suffering from gastrointestinal dysfunction
    Bodil Ohlsson
    Department of Clinical Sciences, Gastroenterology Division, Skane University Hospital, Malmo, Lund University, Lund, Sweden
    BMC Gastroenterol 10:48. 2010
    ..The aim of this study was to examine the presence of such antibodies in patients with dysmotility not subjected to GnRH treatment and study the anti-GnRH antibody effect on enteric neurons viability in vitro...
  84. ncbi Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics
    M Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Aliment Pharmacol Ther 19:379-90. 2004
    ..A knowledge of central and peripheral D2 receptor pharmacology can help the clinician to choose between the antidopaminergic prokinetics to obtain a more favourable risk/benefit ratio...
  85. ncbi Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men
    Amelia N Pilichiewicz
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide SA 5000, Australia
    Am J Physiol Endocrinol Metab 293:E743-53. 2007
    ..These observations have implications for strategies to minimize postprandial glycemic excursions in type 2 diabetes...
  86. ncbi Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway
    Xiao Yu Tian
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR
    Brain Res 1088:101-8. 2006
    ..Thus, it can be concluded that EA attenuates behavioral hyperalgesia and stress-induced colonic motor dysfunction in CVH rats via serotonergic pathway...
  87. ncbi Mechanisms of polymicrobial sepsis-induced ileus
    Marcus Overhaus
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Gastrointest Liver Physiol 287:G685-94. 2004
    ....
  88. ncbi 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors
    Tomonori Kunikata
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Yamashina, Japan
    Dig Dis Sci 47:894-904. 2002
    ....
  89. pmc Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
    J Schirra
    Department of Internal Medicine II, Clinical Research Unit, Ludwig Maximilians University, Marchioninistr 15, Munich 81377, Germany
    Gut 55:243-51. 2006
    ..Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying...
  90. pmc Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice
    R Capasso
    Department of Pharmaceutical Sciences, University of Salerno, via Ponte Don Melillo 84084 Fisciano (SA, Italy
    Br J Pharmacol 134:945-50. 2001
    ..The decreased levels of PEA in croton oil-treated might contribute, at least in part, to the exaggerated transit observed during chronic intestinal inflammation...
  91. ncbi Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice
    Zhi Shan Li
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:2798-807. 2006
    ..Because motility is abnormal when D2 is absent, the net inhibitory DA effect on motility is physiologically significant. The early expression of DA receptors is also consistent with the possibility that DA affects ENS development...
  92. ncbi Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine
    Daniel P Poole
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville 3010, Australia
    Cell Tissue Res 325:413-22. 2006
    ..Expression of the protein and mRNA has been confirmed in extracts containing enteric neurons. The observations suggest that one site of action of 5-HT4 receptor agonists is the intrinsic primary afferent neurons...
  93. ncbi Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity
    H Monnikes
    Department of Medicine, Division of Hepatology and Gastroenterology, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Dig Dis 19:201-11. 2001
    ..g. the amygdala. Stress-induced activation or sensitization of mucosal mast cells in the GI tract seem to be involved in stress-associated alterations of visceral sensitivity...
  94. ncbi Dietary herb extract dai-kenchu-to ameliorates constipation in parkinsonian patients (Parkinson's disease and multiple system atrophy)
    Ryuji Sakakibara
    Mov Disord 20:261-2. 2005
  95. ncbi Mechanisms and treatment of postoperative ileus
    Andrew Luckey
    University of California at Sanf Francisco East Bay, Oakland, USA
    Arch Surg 138:206-14. 2003
    ..To review the pathogenesis and treatment of postoperative ileus...
  96. ncbi Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation
    Shachar Peles
    Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Gastrointest Liver Physiol 285:G577-85. 2003
    ..6 ml. However, responses reached a plateau at a distending volume >0.8 ml. We concluded that enhanced contraction of the antrum can activate vagal afferents signaling to the CNS...
  97. ncbi Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons
    Therese Edholm
    Department of Medicine, Gastroenterology Unit, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Regul Pept 121:25-30. 2004
    ....
  98. ncbi Effect of Dai-kenchu-to on gastrointestinal motility based on differences in the site and timing of administration
    Naruo Kawasaki
    Department of Surgery, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Dig Dis Sci 52:2684-94. 2007
    The purpose of this study was to investigate the effects of the herbal medicine dai-kenchu-to on gastrointestinal motility based on differences in the administration site and timing...
  99. ncbi High-definition spatiotemporal mapping of contractile activity in the isolated proximal colon of the rabbit
    Roger G Lentle
    Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand
    J Comp Physiol B 178:257-68. 2008
    ..The orad movement of watery fluid was possibly due to ripples in the absence of haustra...
  100. ncbi Interstitial cells of Cajal and adaptive relaxation in the mouse stomach
    Devika Dixit
    Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 291:G1129-36. 2006
    ..ICC-IM may be involved in regulation of (distention-induced) myogenic tone...
  101. ncbi Melatonin and serotonin effects on gastrointestinal motility
    P J Thor
    Department of Pathophysiology, Medical College, Jagiellonian University, Czysta 18 str, Cracow, Poland
    J Physiol Pharmacol 58:97-103. 2007
    ..Since of its unique properties M could be considered for prevention or treatment of colorectal cancer, ulcerative colitis, gastric ulcers and irritable bowel syndrome...

Research Grants63

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Nervous System/*growth &amp;development</keyword;keyword>*Gastrointestinal Motility</keyword;keyword>Humans</keyword;keyword>Infant, Newborn</keyword;keyword>Intestinal ..
  2. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..hormone, and neurotensin, that are involved in both the stress response and the modulation of gastrointestinal motility, can stimulate proliferation in human preadipocytes, suggesting their participation in fat expansion, a ..
  3. Ionic currents in gastrointestinal smooth muscle
    Hamid I Akbarali; Fiscal Year: 2013
    ..These changes affect gastrointestinal motility contributing to the clinical expression of altered contractions...
  4. Epigenetic regulation of stem cell senescence in aging
    DAVID TOCHUKWU ASUZU; Fiscal Year: 2011
    ..I propose to study senescence of stem cells for interstitial cells of Cajal, a cell type critical for gastrointestinal motility, as a mechanism of gastrointestinal aging...
  5. Stem cells for novel gene delivery of nitric oxide in the gut
    Hiroshi Mashimo; Fiscal Year: 2013
    ..by applicant): ABSTRACT Deficiency of the gas nitric oxide (NO) has been implicated in a number of gastrointestinal motility disorders including achalasia, diabetic gastroparesis, pyloric stenosis, chronic constipation, and ..
  6. Interstitial Cells of Cajal in Diabetic Gastropathy
    TAMAS ORDOG; Fiscal Year: 2013
    ..The classic view of gastrointestinal motility disorders including diabetic gastroparesis is that they are due to impaired tissue function and ..
  7. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Gastrointestinal motility disorders result in a variety of diseases that cause difficulty in swallowing, heartburn, dyspepsia, ..
  8. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..effects, such as supraspinal analgesia, respiratory depression, miosis, euphoria, nausea, and reduced gastrointestinal motility. These undesirable effects have resulted in serious medical problems for numerous patients and their ..
  9. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..See instructions): This project seeks to identify new therapeutic targets for medical intervention for gastrointestinal motility disorders by understanding how endothelin receptor B (Ednrb) regulates gasrointestinal motlity...
  10. VZV in the enteric nervous system: pathogenesis and consequences
    Michael D Gershon; Fiscal Year: 2013
    ..when abnormal, causes discomfort and may contribute to the pathophysiology or severity of disorders of gastrointestinal motility, secretion, and inflammation...
  11. Genes, Environment &Neural Stem Cell Transplantation in the Gut
    Pankaj J Pasricha; Fiscal Year: 2012
    ..our laboratory has begun investigating the use of NSC as a viable therapeutic strategy for disorders of gastrointestinal motility. Using a strategy of transplanting CNS-derived NSC (CNS-NSC) in mice with a genetic deletion of the ..
  12. Drug-Mediated Alteration of Cytochrome P450
    Yoichi Osawa; Fiscal Year: 2013
    ..cytochrome P450 enzyme, plays a key role in a variety of biological processes, including regulation of gastrointestinal motility and liver drug metabolism...
  13. Automated Intestinal Electrical Stimulation for Diabetes
    Jiande Chen; Fiscal Year: 2013
    ..Based on previous published studies in our group, we have discovered that IES alters gastrointestinal motility, physiology and hormones in a way similar to the gastric bypass procedure: it reduces food intake and ..
  14. BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTION
    RENATO ALBERTO TRAVAGLI; Fiscal Year: 2012
    ..cycle will provide the background information necessary to develop novel therapeutic approaches to the treatment of those functional gastrointestinal motility disorders exacerbated by stress or digestive malfunctions.
  15. CXCR4-Vagal Tone and Gastric motility
    Richard C Rogers; Fiscal Year: 2013
    ..Disruption of gastrointestinal motility, nausea, emesis, and anorexia are common features of neurodegenerative disease...
  16. Role of Endothelin Receptor B signaling in the genesis of aganglionic megacolon
    Miles L Epstein; Fiscal Year: 2012
    ..These studies will benefit patients with Hirchsprung's disease and other gastrointestinal motility disorders because providing functional innervation is a superior alternative to surgical excision, which ..
  17. Role of Prokineticin 2 in Cerebral Ischemia
    Michelle Y Cheng; Fiscal Year: 2010
    ..This protein was first identified in 2001 as a regulator of gastrointestinal motility. Multiple biological roles for PKs have since been discovered, including ones relevant to the central ..
  18. Zebrafish Based Model for Gastrointenstinal Physiology
    ADAM J RICH; Fiscal Year: 2010
    ..New model systems are needed to help identify novel drug targets for the effective treatment of gastrointestinal motility disorders such as constipation, gastroparesis, and bloating...
  19. Transcutaneous electroacupuncture for gastroparesis
    Jiande Chen; Fiscal Year: 2010
    ..A comprehensive team has been assembled to perform the study, including experts in gastrointestinal motility, traditional Chinese medicine and clinical patient care.
  20. Chronic Morphine: Regulation of Ion Conductances
    John T Williams; Fiscal Year: 2013
    ..actions including;depression of respiration, activation of the reward pathway, disruption of normal gastrointestinal motility and analgesia...
  21. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
    ..There is evidence that this may be secondary to changes in gastrointestinal motility and transit...
  22. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2006
    Galanin exerts excitatory and inhibitory effects on gastrointestinal motility either directly by acting on the muscle or indirectly by acting on neuronal pathways...
  23. MOTILITY OF THE DIGESTIVE TRACT IN HEALTH AND DISEASE
    KEITH KELLY; Fiscal Year: 1993
    The objective is to define the electrical, neural and hormonal controls of gastrointestinal motility in health and disease, and to develop new treatments for gastrointestinal motor disorders based on knowledge of these controls...
  24. Short Chain Fatty Acids and Intestinal Barrier Function
    Jing Lin; Fiscal Year: 2007
    ..of SCFAs may arise in premature infants due to increased luminal carbohydrate malabsorption and poor gastrointestinal motility, and may have deleterious effects on mucosal integrity...
  25. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..Specific Aim 3 will test the role of NMDA-Rs in mediating the effects of chronic opiate treatment in gastrointestinal motility and at the receptor level...
  26. SPINAL & BRAIN MODULATION OF GASTROINTESTINAL MOTILITY
    Frank Porreca; Fiscal Year: 1992
    ..Knowledge of the sites and functions of the neuronal "brain-gut" peptides will provide new information about central nervous system-gut interactions...
  27. NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERS
    Christopher Carreras; Fiscal Year: 2000
    ..prokinetic agents with superior pharmacological and pharmacokinetic properties for the treatment of gastrointestinal motility disorders such as gastroesophogeal reflux disease (GERD), gastroparesis, postoperative ileus, ..
  28. Sox10 in Development of the Enteric Nervous System
    E Southard Smith; Fiscal Year: 2004
    Congenital gastrointestinal motility disorders arise as a consequence of anomalies in development of the enteric nervous system (ENS)...
  29. Postnatal development of neurohumoral signaling mechanisms in the gut
    Xiaochun Bian; Fiscal Year: 2010
    ..Closing this knowledge gap is important for understanding childhood gastrointestinal motility and visceral hypersenstivity disorders, which place a large burden on the affected children and their ..
  30. DEVELOPMENTAL ASPECTS OF UPPER GASTROINTESTINAL MOTILITY
    A Hillemeier; Fiscal Year: 1990
    ..This systematic approach to age related changes in upper gastrointestinal motility will lead to more rational therapy for the common clinical problem of gastroesophageal reflux during ..
  31. Intestinal Pacing for Intestinal Pseudo-Obstruction
    Jiande Chen; Fiscal Year: 2007
    ..A competitive team has been assembled including a veteran researcher in gastrointestinal motility and pacing, a surgeon with extensive surgical experience on the gastrointestinal tract and a computer ..
  32. NOVEL ESOPHAGEAL MOTOR FUNCTION ASSESSMENT SYSTEM
    JianFeng Chen; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Functional gastrointestinal motility diseases are common and make up about 40% of all gastroenterology patients...
  33. HYPOTHYROID AND AUTONOMIC CHANGES--ROLE OF MEDULLARY TRH
    Hong Yang; Fiscal Year: 1999
    The central mechanisms responsible for the bradycardia, high blood pressure, gastrointestinal motility disorder, and gastric atrophy induced by hypothyroidism remains unknown...
  34. High-Definition Manometry: A Novel Diagnostic Tool
    Thomas Parks; Fiscal Year: 2006
    b>Gastrointestinal motility disorders remain significant both in terms of prevalence and morbidity (e.g., suffering, functional impairment, and health care resource use)...
  35. COORDINATION OF MOTILITY AND SECRETION
    Helen Cooke; Fiscal Year: 2004
    Enteric infections and inflammation are often associated with disturbances in gastrointestinal motility and secretion. One of the common symptoms is diarrhea...
  36. REGULATION OF CALCIUM RELEASE IN INTESTINAL MYOCYTES
    Klaus Bielefeldt; Fiscal Year: 2002
    The normal gastrointestinal motility depends on a cascade of intracellular signals that translate a signal at the cell membrane into muscle contraction...
  37. Redefinition of Gastroesophageal Reflux in Children
    Hayat Mousa; Fiscal Year: 2004
    ..A recently developed procedure for the recording of gastrointestinal motility by means of multiple intraluminal impedance measurement (MII) is based on the registration of changes in ..
  38. Ligand Binding Domains in the 5-HT3 Receptor
    Tina Machu; Fiscal Year: 2006
    ..In addition to its role in mediating synaptic transmission in the nervous system, it also regulates gastrointestinal motility and the vomiting reflex...
  39. AUTORADIOGRAPHY & PHYSIOLOGY OF GASTROINTESTINE PEPTIDES
    Ann Ouyang; Fiscal Year: 1990
    ..applied to the gastrointestinal tract with respect to neuropeptides and neurotransmitters relevant to gastrointestinal motility. Quantitative autoradiography will allow the comparison of receptor sites and densities in different ..
  40. SOMATO-VISCERAL INTEGRATION IN LATERAL HABENULA
    RUSSELL MC BRIDE; Fiscal Year: 1980
    ..Functional studies implicate the habenula in olfactory and feeding behaviors, gastrointestinal motility, spinal motorneuron activity and endocrine secretion...
  41. CLONING OF THE SEROTONIN 5-HT 1P RECEPTOR
    Theresa Branchek; Fiscal Year: 1990
    ..has been extensively characterized in the enteric nervous system where it functions in the regulation of gastrointestinal motility. In addition, 5-HT like binding sites have been discovered in the pericardium and endocardium of the ..
  42. Gastrointestinal Transit Measurement System
    DAVID KYNOR; Fiscal Year: 2003
    b>Gastrointestinal motility disorders are a significant health problem accounting for millions of physician visits each year. In many patients, measurement of gastrointestinal transit can provide important diagnostic information...
  43. DEVELOPMENT OF MOTILITY VISUALIZATION SYSTEM
    JAE SON; Fiscal Year: 2002
    DESCRIPTION (Verbatim from the Applicant's Abstract): Gastrointestinal motility disorders remain significant both in terms of patient symptom prevalence and health care resource use...
  44. Gastrointestinal Transit Measurement System
    DAVID KYNOR; Fiscal Year: 2006
    b>Gastrointestinal motility disorders are a significant health problem accounting for millions of physician visits each year. In many patients, measurement of gastrointestinal transit can provide important diagnostic information...
  45. 2007 CB2 Cannabinoid Meeting
    Kenneth Mackie; Fiscal Year: 2007
    ..been implicated in processes and diseases as diverse as chronic pain, hepatic fibrosis, osteoporosis, gastrointestinal motility, atherosclerosis, and neuroinflammation...
  46. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  47. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  48. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  49. BIENNIEL AMERICAN MOTILITY SYMPOSIUM
    KENTON SANDERS; Fiscal Year: 1992
    ..scientists together for an intensive 3 day meeting to discuss common interests and progress related to gastrointestinal motility. Past meetings of the American Motility Society have provided a forum for very important symposia, ..
  50. Peptidomimetic Opioids, Synthesis, Structure & Biology
    Yitzhak Tor; Fiscal Year: 2006
    ..mechanistically distinct behavioral models of nociception; (ii) side effect profiles; (iii) effects upon gastrointestinal motility; (iv) tolerance and morphine cross tolerance; (v) effects upon immune function; and (vi) systemic ..
  51. Magnetic Tracking for Drug Delivery and Motility Studies
    Sankaran Kumar; Fiscal Year: 2005
    ..These capabilities will have wide applications in the validation of colonic and enteric drug delivery systems, as well as the diagnosis of gastrointestinal motility disorders.
  52. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  53. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  54. SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMS
    Michael Gershon; Fiscal Year: 2005
    ..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..
  55. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
  56. PURINERGIC NEUROGENIC MUCOSAL SECRETION
    JACKIE WOOD; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  57. BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATION
    JACKIE WOOD; Fiscal Year: 2005
    ..The overall goal of the study is to better understand the role of bradykinin in motility disturbances, diarrhea, abdominal pain and inflammation. ..
  58. VIP-induced gene expression in colonic smooth muscle cells
    Sushil K Sarna; Fiscal Year: 2010
    ..abstract_text> ..
  59. Experimental approaches to understanding the ENS and its disorders
    James Galligan; Fiscal Year: 2006
    ..group of senior and junior scientists and trainees who share a common interest in neural control of gastrointestinal motility in health and disease...
  60. Women's Health Complementary and Alternative Therapies
    Margaret Heitkemper; Fiscal Year: 2004
    ..abstract_text> ..
  61. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2008
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  62. Integrating CAM: Nursing Emphasis
    Margaret Heitkemper; Fiscal Year: 2006
    ..abstract_text> ..