- Weight-reducing effects of the plasma protein encoded by the obese gene
J L Halaas
Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
Science 269:543-6. 1995
..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
- Effects of the obese gene product on body weight regulation in ob/ob mice
M A Pelleymounter
Department of Neurobiology, Amgen, Inc, Thousand Oaks, CA 91320, USA
Science 269:540-3. 1995
..These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite...
- A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
D E Cummings
University of Washington, VA Puget Sound Health Care System and Harborview Medical Center, Seattle, Washington 98108, USA
Diabetes 50:1714-9. 2001
..ghrelin levels increased nearly twofold immediately before each meal and fell to trough levels within 1 h after eating, a pattern reciprocal to that of insulin...
- Stress, eating and the reward system
Tanja C Adam
University of California, San Francisco, Department of Psychiatry, United States
Physiol Behav 91:449-58. 2007
..we attempt to link animal and human literatures to tease apart how different types of psychological stress affect eating. We propose a theoretical model of Reward Based Stress Eating...
- Entrainment of the circadian clock in the liver by feeding
K A Stokkan
National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
Science 291:490-3. 2001
..They also raise the possibility that peripheral circadian oscillators like those in the liver may be coupled to the SCN primarily through rhythmic behavior, such as feeding...
- Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
L A Campfield
Department of Metabolic Diseases, Hoffmann La Roche Incorporated, Nutley, NJ 07110, USA
Science 269:546-9. 1995
..The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance...
- Hypothalamic mTOR signaling regulates food intake
Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
Science 312:927-30. 2006
..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
- Diet-induced obese mice develop peripheral, but not central, resistance to leptin
M van Heek
Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
J Clin Invest 99:385-90. 1997
..These data demonstrate that, in a diet-induced obesity model, mice exhibit resistance to peripherally administered leptin, while retaining sensitivity to centrally administered leptin...
- Divergence of melanocortin pathways in the control of food intake and energy expenditure
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Cell 123:493-505. 2005
..Disassociation of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance...
- Trophic action of leptin on hypothalamic neurons that regulate feeding
Sebastien G Bouret
Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA
Science 304:108-10. 2004
..These results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults...
- Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, Boston, Massachusetts 02215, USA
Nat Neurosci 11:998-1000. 2008
..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance...
- The contribution of expanding portion sizes to the US obesity epidemic
Lisa R Young
Department of Nutrition and Food Studies, New York University, New York City, 10012 1172, USA
Am J Public Health 92:246-9. 2002
- Confirmatory factor analysis of the Child Feeding Questionnaire: a measure of parental attitudes, beliefs and practices about child feeding and obesity proneness
L L Birch
Department of Human Development and Family Studies and Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
Appetite 36:201-10. 2001
..The CFQ is designed for use with parents of children ranging in age from about 2 to 11 years of age...
- Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
Neuron 42:983-91. 2004
..In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis...
- Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Michael J Krashes
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 121:1424-8. 2011
..Due to its ease of use and suitability for both acute and chronic regulation, DREADD technology is ideally suited for investigating the neural circuits hypothesized to regulate energy balance...
- Ghrelin enhances appetite and increases food intake in humans
A M Wren
Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
J Clin Endocrinol Metab 86:5992. 2001
..Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight...
- The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
Science 318:1469-72. 2007
..Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid methylation status is linked to increased fat mass...
- Development of the Healthy Eating Index-2005
Patricia M Guenther
Center for Nutrition Policy and Promotion, US Department of Agriculture, 3101 Park Center Drive, Suite 1034, Alexandria, VA 22302, USA
J Am Diet Assoc 108:1896-901. 2008
The Healthy Eating Index (HEI) is a measure of diet quality as specified by Federal dietary guidance, and publication of the Dietary Guidelines for Americans 2005 necessitated its revision...
- Influence of peers and friends on children's and adolescents' eating and activity behaviors
Sarah Jeanne Salvy
RAND Corporation, Santa Monica, CA 90407 2138, USA
Physiol Behav 106:369-78. 2012
..have been theoretically and empirically related to the "Big Two" contributors to the obesity epidemic, unhealthy eating and physical inactivity...
- Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Endocrinology 145:4880-9. 2004
..Defects in leptin action in the ARC may play a role in the pathogenesis of leptin-resistant obesity...
- Circadian timing of food intake contributes to weight gain
Deanna M Arble
Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois, USA
Obesity (Silver Spring) 17:2100-2. 2009
..A better understanding of the role of the circadian system for weight gain could have important implications for developing new therapeutic strategies for combating the obesity epidemic facing the human population today...
- Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
Cell 88:131-41. 1997
..Our data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R...
- Rapid rewiring of arcuate nucleus feeding circuits by leptin
Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 304:110-5. 2004
..These data suggest that leptin-mediated plasticity in the ob/ob hypothalamus may underlie some of the hormone's behavioral effects...
- Heat or insulation: behavioral titration of mouse preference for warmth or access to a nest
Brianna N Gaskill
Department of Animal Science, Purdue University, West Lafayette, Indiana, United States of America
PLoS ONE 7:e32799. 2012
..Our results suggest that under normal laboratory temperatures, mice should be provided with no less than 6 grams of nesting material, but up to 10 grams may be needed to alleviate thermal distress under typical temperatures...
- Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake
Amanda M Dossat
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4301, USA
J Neurosci 31:14453-7. 2011
..We conclude that that GLP-1Rs in the NAc play a physiologic role in food intake control, and suggest that the GLP-1 projection to NAc core may link satiation signal processing in the hindbrain with forebrain processing of food reward...
- Eating patterns and type 2 diabetes risk in men: breakfast omission, eating frequency, and snacking
Rania A Mekary
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 95:1182-9. 2012
Little is known about the association between eating patterns and type 2 diabetes (T2D) risk.
- Inhibition of food intake in obese subjects by peptide YY3-36
Rachel L Batterham
Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
N Engl J Med 349:941-8. 2003
..However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY...
- Psychometric properties and factor structure of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women. Results from the Swedish Obese Subjects (SOS) study
Health Care Research Unit, Sahlgrenska University Hospital, University of Goteborg, Sweden
Int J Obes Relat Metab Disord 24:1715-25. 2000
To evaluate the construct validity of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women.
- Breakfast skipping and health-compromising behaviors in adolescents and adults
Department of Public Health, PO Box 41, University of Helsinki, Helsinki 00014, Finland
Eur J Clin Nutr 57:842-53. 2003
..To investigate which sociodemographic factors and behaviors are associated with breakfast skipping in adolescents and adults...
- Phenotypic and genetic parameters for different measures of feed efficiency in different breeds of Irish performance-tested beef bulls
J J Crowley
Teagasc, Moorepark Dairy Production Research Centre, Fermoy, Co Cork, Ireland
J Anim Sci 88:885-94. 2010
..Results from this study indicate significant genetic differences in performance and some measures of feed efficiency among performance-tested beef bulls...
- Fine mapping quantitative trait loci for feed intake and feed efficiency in beef cattle
E L Sherman
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
J Anim Sci 87:37-45. 2009
..The identification of these QTL provides a starting point to identify genes affecting feed intake and efficiency for use in marker-assisted selection and management...
- Appetite control: methodological aspects of the evaluation of foods
Institute of Psychological Sciences, University of Leeds, Leeds
Obes Rev 11:251-70. 2010
..One main objective of the report has been to produce guidance on good practice in carrying out appetite research, and not to set down a series of commandments that must be followed...
- The lipid messenger OEA links dietary fat intake to satiety
Gary J Schwartz
Diabetes Research Center, Departments of Medicine and Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
Cell Metab 8:281-8. 2008
..The results suggest that activation of small-intestinal OEA mobilization, enabled by CD36-mediated uptake of dietary oleic acid, serves as a molecular sensor linking fat ingestion to satiety...
- Relationship between stress, eating behavior, and obesity
Susan J Torres
Centre for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
Nutrition 23:887-94. 2007
Stress is thought to influence human eating behavior and has been examined in animal and human studies...
- The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
Douglas A Velásquez
Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
Diabetes 60:1177-85. 2011
..We tested the hypothesis that the central SIRT1/p53 pathway might be mediating the orexigenic action of ghrelin...
- The hormonal control of food intake
Anthony P Coll
Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, United Kingdom
Cell 129:251-62. 2007
..These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas. In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake...
- Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Metab 13:195-204. 2011
..Our results also provide further evidence of the dissociation in pathways mediating the effects of melanocortins on energy balance and glucose homeostasis...
- A role for glucagon-like peptide-1 in the central regulation of feeding
M D Turton
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Nature 379:69-72. 1996
..Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety...
- Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa
Elizabeth A Lawson
Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 97:E1898-908. 2012
..The relationships between oxytocin, food-motivation neurocircuitry, and disordered eating psychopathology have not been investigated in humans.
- A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
University Institute of Drug Dependencies, Department of Psychobiology, University Complutense of Madrid, Madrid 28223, Spain
J Neurosci 22:9612-7. 2002
..Pretreatment with SR141716A enhanced the inhibition of feeding induced by intraperitoneal administration of oleoylethanolamide. The results reveal an unexpected role for peripheral CB1 receptors in the regulation of feeding...
- Association between eating patterns and obesity in a free-living US adult population
Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Am J Epidemiol 158:85-92. 2003
Some studies have suggested that eating patterns, which describe eating frequency, the temporal distribution of eating events across the day, breakfast skipping, and the frequency of eating meals away from home, may be related to obesity...
- Metabolic and hedonic drives in the neural control of appetite: who is the boss?
Hans Rudolf Berthoud
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Curr Opin Neurobiol 21:888-96. 2011
..in the identification of neural circuits that represent the interface between the metabolic and hedonic drives of eating. We will cover these new findings by focusing first on the capacity of metabolic signals to modulate processing of ..
- Energy density, portion size, and eating occasions: contributions to increased energy intake in the United States, 1977-2006
Kiyah J Duffey
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA
PLoS Med 8:e1001050. 2011
..Our objective was to examine the relative contribution of energy density (ED), portion size (PS), and the number of eating/drinking occasions (EOs) to changes in daily TE.
- Associations of marker panel scores with feed intake and efficiency traits in beef cattle using preselected single nucleotide polymorphisms
F D N Mujibi
Department of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
J Anim Sci 89:3362-71. 2011
- Inactivation of the Fto gene protects from obesity
Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitatsstr 1, D 40225 Dusseldorf, Germany
Nature 458:894-8. 2009
..Taken together, these experiments provide, to our knowledge, the first direct demonstration that Fto is functionally involved in energy homeostasis by the control of energy expenditure...
- Central administration of oleic acid inhibits glucose production and food intake
Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Diabetes 51:271-5. 2002
..This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation...
- Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Brain Res 1350:18-34. 2010
..e., hypophagic) responses to stress...
- Enhanced striatal dopamine release during food stimulation in binge eating disorder
Gene Jack Wang
Medical Department, Brookhaven National Laboratory, Upton, New York, USA
Obesity (Silver Spring) 19:1601-8. 2011
Subjects with binge eating disorder (BED) regularly consume large amounts of food in short time periods. The neurobiology of BED is poorly understood. Brain dopamine, which regulates motivation for food intake, is likely to be involved...
- De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance
Andrew A Pierce
Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 30:723-30. 2010
..It further suggests that de novo neurogenesis might serve as a compensatory mechanism contributing to the plastic control of energy balance in response to environmental and physiologic insults...
- Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
Science 322:449-52. 2008
- Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
Nat Neurosci 6:736-42. 2003
..These results show that MC4R signaling controls BDNF expression in the VMH and support the hypothesis that BDNF is an important effector through which MC4R signaling controls energy balance...
- The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors
Suzanne L Dickson
Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE 405 30 Gothenburg, Sweden
J Neurosci 32:4812-20. 2012
- Television-viewing characteristics of adults: correlations to eating practices and overweight and health status
Shanthy A Bowman
Agricultural Research Service, Community Nutrition Research Group, Beltsville Human Nutrition Research Center, United States Department of Agriculture, BARC West, Beltsville, MD 20705 2350, USA
Prev Chronic Dis 3:A38. 2006
The purpose of this study was to examine the associations among television viewing, eating practices, and overweight and health status of a nationally representative sample of adults in the United States.
- A review of family and social determinants of children's eating patterns and diet quality
Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Coll Nutr 24:83-92. 2005
..problem of childhood obesity, recent research has begun to focus on family and social influences on children's eating patterns...
- Partial-genome evaluation of postweaning feed intake and efficiency of crossbred beef cattle
W M Snelling
USDA, ARS, US Meat Animal Research Center, PO Box 166, Clay Center, NE 68933, USA
J Anim Sci 89:1731-41. 2011
- Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms
Elisabeth B Rüttimann
Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, 8603 Schwerzenbach, Switzerland
Endocrinology 150:1174-81. 2009
..The findings suggest that iv GLP-1 infusions do not inhibit eating via hepatic portal or hepatic GLP-1 receptors but may act directly on the brain.
- Leptin receptor signaling in midbrain dopamine neurons regulates feeding
Jonathan D Hommel
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Neuron 51:801-10. 2006
..These data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA dopamine neurons...
- Ghrelin modulates brain activity in areas that control appetitive behavior
Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
Cell Metab 7:400-9. 2008
..This demonstrates that metabolic signals such as ghrelin may favor food consumption by enhancing the hedonic and incentive responses to food-related cues...
- Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
Kelly A Posey
Vanderbilt Medical Center, Nashville TN 37232, USA
Am J Physiol Endocrinol Metab 296:E1003-12. 2009
- Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
James E Blevins
VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004
- Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610 0266, USA
Proc Natl Acad Sci U S A 100:14217-22. 2003
..These data show successful peripheral therapy in a clinically relevant model for human obesity and insulin resistance...
- Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat
Institute of Animal Sciences, Swiss Federal Institute of Technology Zurich, Schwerzenbach 8603, Switzerland
J Neurosci 26:11052-60. 2006
..is unique among gut peptides in that its plasma level increases during fasts and its administration stimulates eating. Although ghrelin physiology has been intensively studied, whether its eating-stimulatory effect arises from ..
- The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
Bruce M King
Department of Psychology, University of New Orleans, New Orleans, LA 70148, USA
Physiol Behav 87:221-44. 2006
- Human distribution and release of a putative new gut hormone, peptide YY
T E Adrian
Gastroenterology 89:1070-7. 1985
..The known potent biologic actions of PYY, its high concentrations in gut endocrine cells, and its release into the circulation after a normal meal suggest that this peptide may function physiologically as a circulating gut hormone...
- Interleukin-6-deficient mice develop mature-onset obesity
Research Center for Endocrinology and Metabolism, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
Nat Med 8:75-9. 2002
..Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents...
- Insulin, leptin, and food reward: update 2008
Dianne P Figlewicz
Metabolism Endocrinology 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle, WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 296:R9-R19. 2009
..The understanding of neuroendocrine modulation of food reward, as well as food reward modulation by diet and obesity, may point to new directions for therapeutic approaches to overeating or eating disorders.
- Ghrelin causes hyperphagia and obesity in rats
A M Wren
Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Diabetes 50:2540-7. 2001
..saline 2.2 +/- 3.8 g, P < 0.05) and adiposity. These data provide evidence that ghrelin is important in long-term control of food intake and body weight and that circulating ghrelin at fasting concentrations may stimulate food intake...
- Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Cell Metab 6:55-68. 2007
..We conclude that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system...
- Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior
UCSF Health Psychology Program, 3333 California St, Suite 465, San Francisco, CA 94118, USA
Psychoneuroendocrinology 26:37-49. 2001
To date, there are few known predictors of stress-induced eating. The purpose of this study was to identify whether physiological and psychological variables are related to eating after stress...
- School food environments and practices affect dietary behaviors of US public school children
Ronette R Briefel
Mathematica Policy Research, Inc, PO Box 2393, Princeton, NJ 08543 2393, USA
J Am Diet Assoc 109:S91-107. 2009
..Changes to school food environments and practices that lead to improved dietary behavior are a powerful strategy to reverse the childhood obesity epidemic...
- Whole genome single nucleotide polymorphism associations with feed intake and feed efficiency in beef cattle
E L Sherman
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
J Anim Sci 88:16-22. 2010
- Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects
Obesity Unit, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
J Clin Endocrinol Metab 91:1735-40. 2006
..The mechanisms underlying weight loss after Roux-en-Y gastric bypass (RYGBP) are not well understood...
- Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
Department of Medicine, Nippon Medical School, Tokyo, Japan
Diabetes 50:2438-43. 2001
..0 +/- 22.5% of saline-treated controls; P < 0.05) in the arcuate nucleus. Thus, the primary hypothalamic targets of ghrelin are NPY/AGRP-containing neurons, and ghrelin is a newly discovered orexigenic peptide in the brain and stomach...
- Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work
Departamento de Anatomia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
Endocrinology 151:1019-29. 2010
..These observations demonstrate that feeding habits may prevent or induce internal desynchrony and obesity...
- Modifying the Healthy Eating Index to assess diet quality in children and adolescents
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
J Am Diet Assoc 104:1375-83. 2004
The Healthy Eating Index (HEI) is a scoring system used by the US government to assess adherence to the Dietary Guidelines for Americans. We examined the ability of the HEI to monitor diet quality among youth.
- Agouti-related peptide-expressing neurons are mandatory for feeding
Institute for Genetics and Center for Molecular Medicine CMMC, Department of Mouse Genetics and Metabolism, University of Cologne, Zülpicher Str 47, 50674 Koln, Germany
Nat Neurosci 8:1289-91. 2005
- Ghrelin action in the brain controls adipocyte metabolism
Laboratory of Metabolism, Division of Endocrinology, Diabetology, and Nutrition, Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
J Clin Invest 116:1983-93. 2006
..These results unravel the existence of what we believe to be a new CNS-based neuroendocrine circuit regulating metabolic homeostasis of adipose tissue...
- Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats
Adam P Chambers
Obesity Research Center and the Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA
Gastroenterology 141:950-8. 2011
..We investigated alterations in glucose metabolism in rats following RYGB or VSG...
- Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating
Physiology and Behaviour Laboratory, Institute of Food Nutrition and Health, Zurich, Schwerzenbach, Switzerland
Am J Physiol Regul Integr Comp Physiol 300:R554-65. 2011
..TAG-derived energy by translating enterocyte fatty acid oxidation (FAO) into vagal afferent signals controlling eating. Peripheral FAO has long been implicated in the control of eating (141)...
- Food neophobia and 'picky/fussy' eating in children: a review
Terence M Dovey
Department of Psychology, Staffordshire University, College Road, Stoke on Trent, Staffordshire ST4 2DE, UK
Appetite 50:181-93. 2008
..been shown to contribute to rejection or acceptance of fruits and vegetables: food neophobia and 'picky/fussy' eating. Food neophobia is generally regarded as the reluctance to eat, or the avoidance of, new foods...
- Normative influences on food intake
C Peter Herman
Department of Psychology, University of Toronto, Toronto, ON, Canada M5S 3G3
Physiol Behav 86:762-72. 2005
Hunger and satiety have conventionally provided the framework for understanding eating and overeating. We argue that hunger and satiety play a relatively small role in everyday eating...
- Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
Pablo B Martínez de Morentin
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Diabetes 61:807-17. 2012
..Overall these data demonstrate that the effects of nicotine on energy balance involve specific modulation of the hypothalamic AMPK-BAT axis. These targets may be relevant for the development of new therapies for human obesity...
- Residual intake and body weight gain: a new measure of efficiency in growing cattle
D P Berry
Animal and Grassland Research and Innovation Centre, Teagasc, Moorepark, Fermoy, Co Cork, Ireland
J Anim Sci 90:109-15. 2012
..The advantages of both reduced daily DMI and greater ADG in animals superior for RIG are demonstrated compared with animals superior for either RFI or RG...
- The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
Scott E Kanoski
Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropharmacology 62:1916-27. 2012
- GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
Amber L Alhadeff
Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Endocrinology 153:647-58. 2012
..Current data highlight these nuclei within the MRS as novel sites for GLP-1R-mediated control of food intake and body weight...
- The importance of exposure for healthy eating in childhood: a review
Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, Gower Street, London, UK
J Hum Nutr Diet 20:294-301. 2007
..If future large-scale interventions prove to be successful, training could be offered to health professionals or directly to parents themselves...
- Effects of food form and timing of ingestion on appetite and energy intake in lean young adults and in young adults with obesity
Richard D Mattes
Department of Foods and Nutrition, Purdue University, 212 Stone Hall, 700 W State St, West Lafayette, IN 47907 2059, USA
J Am Diet Assoc 109:430-7. 2009
Overweight and obesity have been attributed to increased eating frequency and the size of eating events. This study explored the influence of the timing of eating events and food form on appetite and daily energy intake.
- An obligate role of oxytocin neurons in diet induced energy expenditure
Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
PLoS ONE 7:e45167. 2012
..Thus, our study suggests that oxytocin neurons are required to resist the obesity associated with a high fat diet; but their role in feeding is permissive and can be compensated for by redundant pathways...
- Psychological determinants of emotional eating in adolescence
Selena T Nguyen-Rodriguez
Institute for Health Promotion and Disease Prevention, Keck School of Medicine, University of Southern California, 1000 S Freemont Ave, Unit 8, BldgA4, Rm 4102, Alhambra, CA 91803, USA
Eat Disord 17:211-24. 2009
Emotional eating is conceptualized as eating in response to negative affect. Data from a larger study of physical activity was employed to examine the associations among specific emotions/moods and emotional eating in an adolescent sample...
- Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice
Sun Ju Choi
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Diabetes and Obesity Center of Excellence, Seattle, WA 98109, USA
Am J Physiol Endocrinol Metab 300:E1031-7. 2011
..2 g vs. WT: -1.6 ± 0.1, P < 0.05) were increased in myostatin-deficient mice compared with WT controls. We conclude that increased EE, together with increased leptin sensitivity, contributes to low fat mass in mice lacking myostatin...
- Serotonin reciprocally regulates melanocortin neurons to modulate food intake
Lora K Heisler
Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
Neuron 51:239-49. 2006
- The histamine H3 receptor and eating behavior
Maria Beatrice Passani
Dip Farmacologia preclinica e clinica, V le G Pieraccini 6, 50139 Firenze, Italy
J Pharmacol Exp Ther 336:24-9. 2011
..b>Eating behavior is regulated by a complex interplay of central neurotransmitter systems, peripheral endocrine stimuli, ..
- Role of the glucagon-like-peptide-1 receptor in the control of energy balance
Matthew R Hayes
Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
Physiol Behav 100:503-10. 2010
..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009...
- Signals that regulate food intake and energy homeostasis
S C Woods
Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267 0559, USA
Science 280:1378-83. 1998
..This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs...
- Situational effects on meal intake: A comparison of eating alone and eating with others
Marion M Hetherington
Department of Psychology, Glasgow Caledonian University, Glasgow, Scotland, UK
Physiol Behav 88:498-505. 2006
b>Eating in competition with other tasks has been shown to increase food intake, particularly when tasks are cognitively demanding...
- A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans
Research Department of Human Nutrition, Centre for Food, The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark
J Clin Endocrinol Metab 86:4382-9. 2001
..Glucagon-like peptide-1 infusion reduces energy intake dose dependently in both lean and overweight subjects. A reduced gastric emptying rate may contribute to the increased satiety induced by glucagon-like peptide-1...
- Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit
Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia
Mol Cell Endocrinol 316:109-19. 2010
- Leptin regulates striatal regions and human eating behavior
I Sadaf Farooqi
University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
Science 317:1355. 2007
- The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy
Mark H Vickers
Liggins Institute, University of Auckland, Auckland, New Zealand
Endocrinology 149:1906-13. 2008
..These data further reinforce the importance of leptin in determining long-term energy homeostasis, and suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status...
- Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling
Christa M Patterson
Neurology Service 127C VA Medical Center, 385 Tremont Ave, E Orange, NJ 07018 1095, USA
Am J Physiol Regul Integr Comp Physiol 296:R537-48. 2009
..These data suggest that brief postweaning exercise in DIO rats that are inherently leptin resistant causes a sustained resistance to obesity on HE diet, which is, in part, due to increased central leptin sensitivity...
- The regulation of seasonal changes in food intake and body weight
F J P Ebling
School of Biomedical Sciences and Institute of Neuroscience, University of Nottingham Medical School, Nottingham, UK
J Neuroendocrinol 20:827-33. 2008