recovery of function

Summary

Summary: A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.

Top Publications

  1. ncbi What do motor "recovery" and "compensation" mean in patients following stroke?
    Mindy F Levin
    School of Physical and Occupational Therapy, McGill University and Center for Interdisciplinary Research in Rehabilitation, Jewish Rehabilitation Hospital, Montreal, Quebec, Canada
    Neurorehabil Neural Repair 23:313-9. 2009
  2. ncbi Arthroscopic rotator cuff repair: prospective evaluation with sequential ultrasonography
    Shane J Nho
    Sports Medicine and Shoulder Surgery Service, Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York, USA
    Am J Sports Med 37:1938-45. 2009
  3. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Japan
    Cell 110:429-41. 2002
  4. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
  5. ncbi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
  6. ncbi Evidence-based surgical care and the evolution of fast-track surgery
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, Rigshospitalet, Copenhagen, Denmark
    Ann Surg 248:189-98. 2008
  7. ncbi Locomotor training improves daily stepping activity and gait efficiency in individuals poststroke who have reached a "plateau" in recovery
    Jennifer L Moore
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, IL, USA
    Stroke 41:129-35. 2010
  8. ncbi Influence of interhemispheric interactions on motor function in chronic stroke
    Nagako Murase
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 55:400-9. 2004
  9. ncbi The effect of voluntary exercise exposure on histological and neurobehavioral outcomes after ischemic brain injury in the rat
    Raul Marin
    Department of the Army, Walter Reed Army Medical Center, 6900 Georgia Avenue, Washington, DC 20307, USA
    Physiol Behav 80:167-75. 2003
  10. ncbi Analysis of fMRI and finger tracking training in subjects with chronic stroke
    James R Carey
    Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
    Brain 125:773-88. 2002

Research Grants

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
  2. Low-Voltage Nerve Electrophoresis In Vivo: Role in Peripheral Nerve Regeneration
    Roger D Madison; Fiscal Year: 2010
  3. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2010
  4. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  5. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  6. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN KARTJE MD; Fiscal Year: 2009
  7. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2006
  8. Proteasome, protein oxidation, and cardiomyocyte function.
    Xuejun Wang; Fiscal Year: 2010
  9. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2009
  10. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2010

Detail Information

Publications248 found, 100 shown here

  1. ncbi What do motor "recovery" and "compensation" mean in patients following stroke?
    Mindy F Levin
    School of Physical and Occupational Therapy, McGill University and Center for Interdisciplinary Research in Rehabilitation, Jewish Rehabilitation Hospital, Montreal, Quebec, Canada
    Neurorehabil Neural Repair 23:313-9. 2009
    ....
  2. ncbi Arthroscopic rotator cuff repair: prospective evaluation with sequential ultrasonography
    Shane J Nho
    Sports Medicine and Shoulder Surgery Service, Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York, USA
    Am J Sports Med 37:1938-45. 2009
    ..Recent studies have demonstrated predictable healing after arthroscopic rotator cuff repair at a single time point, but few studies have evaluated tendon healing over time...
  3. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Japan
    Cell 110:429-41. 2002
    ..These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases...
  4. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
    ..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains...
  5. ncbi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
    ..The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury...
  6. ncbi Evidence-based surgical care and the evolution of fast-track surgery
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, Rigshospitalet, Copenhagen, Denmark
    Ann Surg 248:189-98. 2008
    ..Optimization of postoperative outcome requires the application of evidence-based principles of care carefully integrated into a multimodal rehabilitation program...
  7. ncbi Locomotor training improves daily stepping activity and gait efficiency in individuals poststroke who have reached a "plateau" in recovery
    Jennifer L Moore
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, IL, USA
    Stroke 41:129-35. 2010
    ....
  8. ncbi Influence of interhemispheric interactions on motor function in chronic stroke
    Nagako Murase
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 55:400-9. 2004
    ..It is conceivable that this abnormality could adversely influence motor recovery in some patients with subcortical stroke, an interpretation consistent with models of interhemispheric competition in motor and sensory systems...
  9. ncbi The effect of voluntary exercise exposure on histological and neurobehavioral outcomes after ischemic brain injury in the rat
    Raul Marin
    Department of the Army, Walter Reed Army Medical Center, 6900 Georgia Avenue, Washington, DC 20307, USA
    Physiol Behav 80:167-75. 2003
    ....
  10. ncbi Analysis of fMRI and finger tracking training in subjects with chronic stroke
    James R Carey
    Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
    Brain 125:773-88. 2002
    ..We concluded that individuals with chronic stroke receiving intensive tracking training showed improved tracking accuracy and grasp and release function, and that these improvements were accompanied by brain reorganization...
  11. ncbi Recovery of function in humans: cortical stimulation and pharmacological treatments after stroke
    Agnes Floel
    Department of Neurology, University of Muenster, Germany
    Neurobiol Dis 37:243-51. 2010
    ..Subsequently, we expand on possibilities of adjuvant therapy in human rehabilitation using cortical stimulation and pharmacological treatments. Finally, we suggest future directions for research in this field...
  12. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  13. ncbi Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
    R L Zhang
    Department of Neurology, Henri Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroscience 105:33-41. 2001
    ..From these data we suggest that focal cerebral ischemia induces transient and regional specific increases in cell proliferation in the ipsilateral hemisphere and that proliferating progenitor cells may exist in the adult cortex...
  14. ncbi Functional outcome at 2.5, 5, 9, and 24 months after injury in the Netherlands
    Suzanne Polinder
    Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
    J Trauma 62:133-41. 2007
    ..The collection of empirical data on the frequency, severity, and duration of functioning is a prerequisite to identify patient groups with long term or permanent disability...
  15. ncbi The importance of patient expectations in predicting functional outcomes after total joint arthroplasty
    Nizar N Mahomed
    Division of Orthopaedic Surgery, Toronto Western Hospital, University of Toronto, ON, Canada
    J Rheumatol 29:1273-9. 2002
    ..Greater understanding of the relationship between expectations and outcomes may improve the process of care and outcomes of TJA...
  16. ncbi cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
    Nat Med 10:610-6. 2004
    ..These findings show that cAMP levels are key for protection, growth and myelination of injured CNS axons in vivo and recovery of function.
  17. ncbi The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
    Florence M Bareyre
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 7:269-77. 2004
    ..Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans...
  18. ncbi Health related quality of life outcomes after total hip and knee arthroplasties in a community based population
    C A Jones
    Department of Public Health Sciences, University of Alberta, Edmonton, Canada
    J Rheumatol 27:1745-52. 2000
    ..To quantify the magnitude of change seen with pain, function, and quality of life outcomes 6 months after total hip and knee arthroplasties (THA, TKA) within a community based cohort of a regional health district...
  19. ncbi Robot-assisted therapy for long-term upper-limb impairment after stroke
    Albert C Lo
    Providence Veterans Affairs Medical Center and Brown University, Providence, RI 02909, USA
    N Engl J Med 362:1772-83. 2010
    ..Effective rehabilitative therapies are needed for patients with long-term deficits after stroke...
  20. ncbi Motor imagery after stroke: relating outcome to motor network connectivity
    Nikhil Sharma
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Ann Neurol 66:604-16. 2009
    ..This raises an important question: how far does recovery of motor performance depend on the processes that precede movement execution involving the premotor and prefrontal cortex, rather than recovery of the corticospinal system alone?..
  21. ncbi Neural basis and recovery of spatial attention deficits in spatial neglect
    Maurizio Corbetta
    Department of Neurology, Washington University, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 8:1603-10. 2005
    ....
  22. ncbi A three-dimensional reconstruction plate for displaced midshaft fractures of the clavicle
    J W Shen
    Department of Orthopaedic and Traumatic Surgery Zhejiang Province TCM Hospital, Hangzhou 310006, Zheijiang Province, People s Republic of China
    J Bone Joint Surg Br 90:1495-8. 2008
    ..05). If fixation of midshaft fractures of the clavicle with a plate is indicated, a 3D reconstruction plate is better than one placed superiorly, because it is consistent with the stress distribution and shape of the clavicle...
  23. ncbi Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
    Guillermo Garcia-Alias
    Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
    Nat Neurosci 12:1145-51. 2009
    ..Our results indicate that chondroitinase treatment opens a window during which rehabilitation can promote recovery. However, only the trained skills are improved and other functions may be negatively affected...
  24. ncbi Neural correlates of motor recovery after stroke: a longitudinal fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:2476-96. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear temporal relationship between recovery and task-related activation of the motor system after stroke...
  25. ncbi Targeting recovery: priorities of the spinal cord-injured population
    Kim D Anderson
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 4292, USA
    J Neurotrauma 21:1371-83. 2004
    ..In order to improve the relevance of research in this area, the concerns of the SCI population must be better known and taken into account. This approach is consistent with and emphasized by the new NIH roadmap to discovery...
  26. ncbi Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer
    N S Abraham
    Surgical Outcomes Research Centre, Central Sydney Area Health Service, University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Br J Surg 91:1111-24. 2004
    ..CONCLUSION: LR for colorectal cancer is associated with lower morbidity, less pain, a faster recovery and a shorter hospital stay than open resection, without compromising oncological clearance...
  27. ncbi The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08820, USA
    Arch Phys Med Rehabil 85:2020-9. 2004
    ..To determine the measurement properties and diagnostic utility of the JFK Coma Recovery Scale-Revised (CRS-R)...
  28. ncbi Rasch analysis of a new stroke-specific outcome scale: the Stroke Impact Scale
    Pamela W Duncan
    Brooks Center for Rehabilitation Studies, University of Florida, Gainesville, FL 32610-0185, USA
    Arch Phys Med Rehabil 84:950-63. 2003
    ....
  29. ncbi Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1254:10-7. 2009
    ..Even a modest improvement in nerve regeneration could have significant clinical implications for reconstructive nerve surgery...
  30. ncbi The impact of physical therapy on functional outcomes after stroke: what's the evidence?
    R P S Van Peppen
    Department of Physical Therapy, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Rehabil 18:833-62. 2004
    ..To determine the evidence for physical therapy interventions aimed at improving functional outcome after stroke...
  31. ncbi Use of the reverse shoulder prosthesis for the treatment of failed hemiarthroplasty in patients with glenohumeral arthritis and rotator cuff deficiency
    J C Levy
    Orthopaedic Institute at Holy Cross, Fort Lauderdale, Florida 33308, USA
    J Bone Joint Surg Br 89:189-95. 2007
    ..However, high rates of complications were associated with glenoid and proximal humeral bone loss...
  32. ncbi Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery
    J Girgis
    McGill University, Centre for Neuronal Survival, Montreal, Canada
    Brain 130:2993-3003. 2007
    ....
  33. ncbi Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke
    R Lindenberg
    Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Neurology 74:280-7. 2010
    ....
  34. ncbi Time course of trunk, arm, leg, and functional recovery after ischemic stroke
    Geert Verheyden
    Katholieke Universiteit Leuven, Department of Rehabilitation Sciences, Leuven, Belgium
    Neurorehabil Neural Repair 22:173-9. 2008
    ..Patterns of recovery provide useful information concerning the potential of physical recovery over time and therefore the setting of realistic goals for rehabilitation programs...
  35. ncbi Virtual reality in stroke rehabilitation: a systematic review of its effectiveness for upper limb motor recovery
    Amy Henderson
    Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Top Stroke Rehabil 14:52-61. 2007
    ..One intervention showing promise is virtual reality (VR), using either immersive or nonimmersive technology. Before recommending VR for use in clinical practice, it is important to understand the evidence regarding its effectiveness...
  36. ncbi Indirect reduction and percutaneous fixation versus open reduction and internal fixation for displaced intra-articular fractures of the distal radius: a randomised, controlled trial
    H J Kreder
    Division of Orthopaedics, University of Toronto, Ontario M4N 3M5, Canada
    J Bone Joint Surg Br 87:829-36. 2005
    ....
  37. ncbi Tricortical versus quadricortical syndesmosis fixation in ankle fractures: a prospective, randomized study comparing two methods of syndesmosis fixation
    Per Høiness
    Ullevaal University Hospital, Oslo, Norway
    J Orthop Trauma 18:331-7. 2004
    ..To assess short-term functional results in 2 types of syn-desmotic fixation, comparing the traditional rigid quadricortical syndesmotic screw fixation with a more dynamic tricortical screw fixation...
  38. ncbi Neglect treatment by prism adaptation: what recovers and for how long
    Andrea Serino
    Dipartimento di Psicologia, Universita di Bologna, Bologna, Italy
    Neuropsychol Rehabil 17:657-87. 2007
    ....
  39. ncbi Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury
    Akiyuki Hiraga
    Department of Neurobiology, Chiba University Graduate School of Medicine, Chiba, Japan
    J Peripher Nerv Syst 11:217-24. 2006
    ..In addition, fasudil does not suppress the myelination of regenerating axons. These findings suggest that RhoA/Rho-kinase may be a practical molecular target to enhance axonal regeneration in human peripheral neuropathies...
  40. ncbi Epidemiology of renal recovery after acute renal failure
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Curr Opin Crit Care 12:544-50. 2006
    ..Herein, the epidemiology of renal recovery after acute renal failure will be described, along with potential predictive factors and interventions...
  41. ncbi Improvements in speed-based gait classifications are meaningful
    Arlene Schmid
    Department of Occupational Therapy, Indiana University School of Health and Rehabilitation Sciences, and the Richard L Roudebush VA Medical Center, Indianapolis, IN 46202 5119, USA
    Stroke 38:2096-100. 2007
    ..8 m/s). The purpose of the current study was to determine whether changes in velocity-based community ambulation classification were related to clinically meaningful changes in stroke-related function and quality of life...
  42. ncbi Syndesmotic screw fixation in Weber C ankle injuries--should the screw be removed before weight bearing?
    David Paul Bell
    Department of Orthopaedic Surgery, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Republic of Singapore
    Injury 37:891-8. 2006
    ..To compare the outcomes of Weber C ankle fractures treated with syndesmotic screw fixation where the screw was removed prior to weight bearing against those where the screw was left in situ indefinitely...
  43. ncbi Predicting mobility outcome one year after stroke: a prospective cohort study
    Ingrid G L van de Port
    Centre of Excellence for Rehabilitation Medicine Utrecht, Rehabilitation Centre De Hoogstraat, Utrecht, The Netherlands
    J Rehabil Med 38:218-23. 2006
    ..To develop a prognostic model to predict mobility outcome one year post-stroke...
  44. ncbi Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery
    Yona Goldshmit
    Centre for Neuroscience, School of Physiotherapy, University of Melbourne, Melbourne, Australia
    J Neurotrauma 25:449-65. 2008
    ..However, there was no axonal regeneration into or across the lesion site indicating that the improved behaviour may have been, at least in part, due to enhanced neural activity above the lesion site...
  45. ncbi Change in muscle mass and muscle strength after a hip fracture: relationship to mobility recovery
    M Visser
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 55:M434-40. 2000
    ..Hip fracture in elderly persons has a serious impact on long-term physical function. This study determines the change in muscle strength and muscle mass after a hip fracture, and the associations between these changes and mobility recovery...
  46. ncbi Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..These findings provide a strategy by which individuals with spinal cord injuries could regain substantial levels of motor control...
  47. ncbi Determinants of return to work following non life threatening acute orthopaedic trauma: a prospective cohort study
    Fiona J Clay
    Monash University, Accident Research Centre Building 70, Clayton Victoria, 3800, Australia
    J Rehabil Med 42:162-9. 2010
    ..To determine factors associated with return to work following acute non-life-threatening orthopaedic trauma...
  48. ncbi The relationship between admission hemoglobin level and outcome after hip fracture
    Konrad I Gruson
    Geriatric Hip Fracture Research Group, Department of Orthopaedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003, USA
    J Orthop Trauma 16:39-44. 2002
    ..CONCLUSIONS: Patients at risk for poor outcomes after hip fracture can be identified by assessing hemoglobin levels at hospital admission...
  49. ncbi Compensatory changes at the cerebral cortical level after spinal cord injury
    Yukio Nishimura
    From the Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Neuroscientist 15:436-44. 2009
    ..These changes in the activation pattern of motor-related areas represent an adaptive strategy for functional compensation after spinal cord injury...
  50. ncbi Long-term outcomes of chronic minimally conscious and vegetative states
    J Luaute
    Hospices Civils de Lyon, Rééducation Neurologique, Mouvement et Handicap, Hopital Henry Gabrielle, Saint Genis Laval Université de Lyon, Universite Lyon 1, Biologie Humaine, Faculte de Medecine, Lyon, France
    Neurology 75:246-52. 2010
    ....
  51. ncbi Prediction of global left ventricular functional recovery in patients with heart failure undergoing surgical revascularisation, based on late gadolinium enhancement cardiovascular magnetic resonance
    Tammy J Pegg
    University of Oxford Centre for Clinical Magnetic Resonance Research, UK
    J Cardiovasc Magn Reson 12:56. 2010
    ..Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...
  52. ncbi Quality of life after stroke: the importance of a good recovery
    Francisco Javier Carod-Artal
    Department of Neurology, Sarah Hospital, The Sarah Network of Rehabilitation Hospitals, Brasilia, Brazil
    Cerebrovasc Dis 27:204-14. 2009
    ..Health-related quality of life (HRQoL) is a recognized and important outcome after stroke. An increased survival and the presence of moderate impairment in long-term stroke survivors impact their HRQoL...
  53. ncbi Trunk control as an early predictor of comprehensive activities of daily living function in stroke patients
    Ching lin Hsieh
    School of Occupational Therapy, College of Medicine, National Taiwan University, Republic of China
    Stroke 33:2626-30. 2002
    ..The objective of this study was to assess the relationship between trunk control at an early stage and comprehensive ADL function (as assessed by combining basic ADL and instrumental ADL [IADL]) in patients at 6 months after stroke...
  54. ncbi Validation of the Charlson Comorbidity Index for predicting functional outcome of stroke
    Annie Tessier
    School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montreal, QC, Canada
    Arch Phys Med Rehabil 89:1276-83. 2008
    ....
  55. ncbi Stroke in the very old: incidence, risk factors, clinical features, outcomes and access to resources--a 22-year population-based study
    Yannick Bejot
    Stroke Registry of Dijon Inserm et Institut de Veille Sanitaire, EA4184, University Hospital and Faculty of Medicine and Department of Neurology, Dijon, France ybejot yahoo fr
    Cerebrovasc Dis 29:111-21. 2010
    ..For several years, the burden of stroke in very old patients has been increasing in western countries. Nevertheless, we have little information about this new challenge in individuals >or=80...
  56. ncbi An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
    Songlin Li
    Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Nat Neurosci 13:1496-504. 2010
    ..This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery...
  57. ncbi Ependymal cell reactions in spinal cord segments after compression injury in adult rat
    Masaki Takahashi
    Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
    J Neuropathol Exp Neurol 62:185-94. 2003
    ....
  58. ncbi Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand
    Dennis A Nowak
    Department of Neurology, University Hospital, University of Cologne, Cologne, Germany
    Neurorehabil Neural Repair 23:641-56. 2009
    ..This review critically summarizes the data supporting the use of novel electrophysiological concepts in the rehabilitation of hand function after stroke...
  59. ncbi Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury
    Stephanie Lord-Fontaine
    BioAxone Therapeutic Inc, Montreal, Quebec, Canada
    J Neurotrauma 25:1309-22. 2008
    ..Rats gained body weight normally, and BA-210 treatment had no impact on the development of allodynia. Inactivating Rho with BA-210 holds promise for treating patients with SCI...
  60. ncbi Promoting axonal rewiring to improve outcome after stroke
    Larry I Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Program, Children s Hospital, USA
    Neurobiol Dis 37:259-66. 2010
    ..These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke...
  61. ncbi A new rating scale for open-field evaluation of behavioral recovery after cervical spinal cord injury in rats
    Marina Martinez
    Neurosciences Intégratives et Adaptatives, UMR 6149, Universite de Provence CNRS, Marseille, France
    J Neurotrauma 26:1043-53. 2009
    ..See online Supplementary Material (scoring spreadsheet and videotape recordings) at www.liebertonline.com...
  62. ncbi The value of conservative treatment in ruptures of the anterior cruciate ligament (ACL)
    Alexander Strehl
    Department of Orthopaedic Surgery, University Hospital Inselspital, Bern, Switzerland
    J Trauma 62:1159-62. 2007
    ..Patient selection was performed using a preoperative screening protocol based on the structural damage, clinical symptoms, compliance, sportive activity, and the consent of a well-informed patient...
  63. ncbi Observation of amounts of movement practice provided during stroke rehabilitation
    Catherine E Lang
    Program in Physical Therapy, Program in Occupational Therapy, and Department of Neurology, Washington University, St Louis, MO, USA
    Arch Phys Med Rehabil 90:1692-8. 2009
    ..Lang CE, MacDonald JR, Reisman DS, Boyd L, Jacobson Kimberley T, Schindler-Ivens SM, Hornby TG, Ross SA, Scheets PL. Observation of amounts of movement practice provided during stroke rehabilitation...
  64. ncbi Treatment of anterior cruciate ligament injuries with special reference to graft type and surgical technique: an assessment of randomized controlled trials
    Kristian Samuelsson
    Department of Orthopaedics, Sahlgrenska University Hospital, SE 431 80, Molndal, Sweden
    Arthroscopy 25:1139-74. 2009
    ..The secondary aims were to identify the relative strengths and weaknesses of the selected studies, to resolve contradictions in the literature, and to evaluate the need for further studies...
  65. ncbi Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury
    Jason Sharp
    Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Department of Anatomy and Neurobiology, School of Medicine, 2111 Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, California 92697 4292, USA
    Stem Cells 28:152-63. 2010
    ..These findings further our understanding of the histopathology and functional outcomes of cervical SCI, define potential therapeutic targets, and support the use of these cells as a treatment for cervical SCI...
  66. ncbi Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury
    J Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 21:5272-80. 2001
    ....
  67. ncbi Lateral fluid percussion brain injury: a 15-year review and evaluation
    Hilaire J Thompson
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 22:42-75. 2005
    ....
  68. ncbi Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage
    Jeffrey A Kleim
    McKnight Brain Institute, University of Florida, Gainesville, and Brain Rehabilitation Research Center 151A, Malcom Randall VA Hospital, 1610 SW Archer Road, Gainesville, FL 32610, USA
    J Speech Lang Hear Res 51:S225-39. 2008
    ..This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain...
  69. ncbi Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients
    Karen V Andersen
    Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 78:180-6. 2007
    ..We compared wound infiltration combined with intraarticular injection of local anesthetics for pain relief after total hip arthroplasty (THA) with the well-established practice of epidural infusion...
  70. ncbi The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury
    Frank Krueger
    Department of Molecular Neuroscience, George Mason University, Fairfax, Virginia 22030, USA
    J Neurosci 31:598-606. 2011
    ..A better understanding of these mechanisms could be instrumental in the development and application of effective therapeutic strategies to facilitate recovery from TBI...
  71. ncbi Absence of large-scale dendritic plasticity of layer 5 pyramidal neurons in peri-infarct cortex
    Ricardo Mostany
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Neurosci 31:1734-8. 2011
    ..These results help resolve a long-standing debate regarding the role of large-scale dendritic plasticity of pyramidal neurons in functional recovery after cortical injury...
  72. ncbi Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
    Clare L Parish
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 118:149-60. 2008
    ....
  73. ncbi Normalisation of physical function by infliximab in patients with RA: factors associated with normal physical function
    Hayato Nagasawa
    Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    Clin Exp Rheumatol 28:365-72. 2010
    ..We conducted a two-year prospective study to identify possible factors associated with normalisation of physical function by infliximab treatment in 125 patients with rheumatoid arthritis (RA)...
  74. ncbi The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury
    Ying Yuan
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China
    Brain Res Bull 81:25-32. 2010
    ..These findings suggest that plant polypeptides, ABPP, may be a potential agent in ameliorating of neuropathy caused by sciatic nerve crush...
  75. ncbi The effect of balance training on balance performance in individuals poststroke: a systematic review
    Anat Lubetzky-Vilnai
    Department of Rehabilitation Medicine, University of Washington, Seattle, WA 98195, USA
    J Neurol Phys Ther 34:127-37. 2010
    ..On the basis of this evidence, we also provide recommendations for exercise prescription in such programs...
  76. ncbi The septo-hippocampal system, learning and recovery of function
    Grazyna Niewiadomska
    Department of Neurophysiology, Nencki Institute, Warsaw, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 33:791-805. 2009
    ..Yet, a decline in cholinergic markers in aging and dementia still stands as the most central piece of evidence for a link between the cholinergic system and cognition and appear to provide valuable targets for therapeutic approaches...
  77. ncbi Efficacy of rehabilitative experience declines with time after focal ischemic brain injury
    Jeff Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's Campus, Newfoundland, Canada A1B 3V6
    J Neurosci 24:1245-54. 2004
    ..These findings have important implications for rehabilitation of stroke patients, many of whom experience considerable delays before therapy is initiated...
  78. ncbi Effects of task-specific locomotor and strength training in adults who were ambulatory after stroke: results of the STEPS randomized clinical trial
    Katherine J Sullivan
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089, USA
    Phys Ther 87:1580-602. 2007
    ..A phase II, single-blinded, randomized clinical trial was conducted to determine the effects of combined task-specific and lower-extremity (LE) strength training to improve walking ability after stroke...
  79. ncbi Delirium symptoms in post-acute care: prevalent, persistent, and associated with poor functional recovery
    Edward R Marcantonio
    Research and Training Institute, and Department of Medicine, Hebrew Rehabilitation Center for Aged, Harvard Medical School, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 51:4-9. 2003
    ..To determine the prevalence of delirium symptoms at the time of admission to post-acute facilities, the persistence of delirium symptoms in this setting, and the association of delirium symptoms with functional recovery...
  80. ncbi Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats
    John C Gensel
    STAR Laboratories, Laboratory for Neural Repair, Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:36-54. 2006
    ....
  81. ncbi Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice
    Yutaka Nishio
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neuropathol Exp Neurol 66:724-31. 2007
    ..G-CSF is currently used in the clinic for hematopoietic stimulation, and its ongoing clinical trial for brain infarction makes it an appealing molecule that could be rapidly placed into trials for patients with acute SCI...
  82. ncbi Correlation of pain relief with physical function in hand osteoarthritis: randomized controlled trial post hoc analysis
    H Richard Barthel
    Private Practice Rheumatology, P, O, Box 30813, Santa Barbara, CA 93130, USA
    Arthritis Res Ther 12:R7. 2010
    ..The current analysis examined the relationship of pain relief with measures of function and global rating of disease in patients with hand OA...
  83. ncbi Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction
    Xian Liang Tang
    Division of Cardiovascular Medicine and Institute of Molecular Cardiology, University of Louisville, KY 40292, USA
    Circ J 74:390-404. 2010
    ..This report summarizes the current data from those studies and discusses the potential implication of these cells in developing clinically-relevant stem cell-based therapeutic strategies for cardiac regeneration...
  84. ncbi Cerebral white matter recovery in abstinent alcoholics--a multimodality magnetic resonance study
    Stefan Gazdzinski
    Centre for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Centre, San Francisco, USA
    Brain 133:1043-53. 2010
    ....
  85. ncbi Recovery of sensorimotor function after experimental stroke correlates with restoration of resting-state interhemispheric functional connectivity
    Maurits P A van Meer
    Biomedical Magnetic Resonance Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 30:3964-72. 2010
    ....
  86. ncbi Galectin-1 in regenerating motoneurons
    J McGraw
    International Collaboration on Repair Discoveries, 6270 University Boulevard, University of British Columbia, Vancouver, Canada, V6T 1Z4
    Eur J Neurosci 20:2872-80. 2004
    ..Galectin-1 null mutant mice showed an attenuated rate of functional recovery of whisking movement after a facial nerve crush...
  87. ncbi The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury
    Claudia Pitzer
    Sygnis Bioscience, Im Neuenheimer Feld, Heidelberg, Germany
    J Neurochem 113:930-42. 2010
    ..We show that G-CSF improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. We conclude that G-CSF constitutes a promising and feasible new therapy option for SCI...
  88. ncbi The effect of derotational humeral osteotomy on global shoulder function in brachial plexus birth palsy
    Peter M Waters
    Department of Orthopaedic Surgery, Children s Hospital, 300 Longwood Avenue, Hunn 2, Boston, MA 02115, USA
    J Bone Joint Surg Am 88:1035-42. 2006
    ..The purpose of this study was to determine the effects of these procedures on shoulder function and joint morphology...
  89. ncbi Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines
    A A Kocher
    Department of Surgery, Medicine, and Pathology, Columbia University, New York, USA
    J Mol Cell Cardiol 40:455-64. 2006
    ....
  90. ncbi Outcomes of osteochondral lesions of the knee repaired with a bioabsorbable device
    Joshua S Dines
    Sports Medicine Service, Hospital for Special Surgery, New York, New York, USA
    Arthroscopy 24:62-8. 2008
    ..We sought to evaluate the functional and radiographic outcome of osteochondral lesions involving the femoral condyle that were arthroscopically repaired via a bioabsorbable fixation device made of self-reinforced poly-L-lactic acid...
  91. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095-1735, USA
    J Neurosci 26:13007-16. 2006
    ..These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury...
  92. ncbi Mental practice improves hand function after hemiparetic stroke
    Katharina Müller
    Neurological Therapy Center, Department of Neurology, University Hospital Dusseldorf, Dusseldorf, Germany
    Restor Neurol Neurosci 25:501-11. 2007
    ..In a multiple baseline design, we tested the hypothesis that imagery of finger movements is a specific strategy to improve hand function...
  93. ncbi Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial
    Jeannette Hofmeijer
    Department of Neurology, Rijnstate Hospital, Wagnerlann 55, Arnhem, Netherlands
    Lancet Neurol 8:326-33. 2009
    ..The aim of HAMLET was to assess the effect of decompressive surgery within 4 days of the onset of symptoms in patients with space-occupying hemispheric infarction...
  94. ncbi Midazolam challenge reinduces neurological deficits after transient ischemic attack
    Ronald M Lazar
    From the Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 34:794-6. 2003
    ..Having previously shown that an experimental challenge with the GABAA agonist midazolam in recovered stroke patients can reinduce the acute clinical state, we determined whether TIA patients would demonstrate a similar effect...
  95. ncbi Changes in effective connectivity of the primary motor cortex in stroke patients after rehabilitative therapy
    Philippe A Chouinard
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Exp Neurol 201:375-87. 2006
    ....
  96. ncbi Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1990-2002)
    Bruno Will
    Laboratoire de Neurosciences Comportementales et Cognitives, Institut Fédératif des Neurosciences, Universite Louis Pasteur, UMR 7521, CNRS, Strasbourg, France
    Prog Neurobiol 72:167-82. 2004
    ..Finally, other recent reports emphasize that the treatment parameters may be changed in order to approximate clinical/rehabilitation conditions and, nevertheless, remain effective...
  97. ncbi Effect of Iyengar yoga therapy for chronic low back pain
    Kimberly Anne Williams
    Dept Community Medicine, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Pain 115:107-17. 2005
    ..These preliminary data indicate that the majority of self-referred persons with mild chronic low back pain will comply to and report improvement on medical and functional pain-related outcomes from Iyengar yoga therapy...
  98. ncbi Bridging-to-recovery
    R Hetzer
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum, Berlin, Germany
    Ann Thorac Surg 71:S109-13; discussion S114-5. 2001
    ..In a subgroup of selected patients, some hearts recovered considerable function. In these patients the device was removed and cardiac transplantation was no longer necessary. We report our long-term experience with these weaned patients...
  99. ncbi GABAergic systems in the vestibular nucleus and their contribution to vestibular compensation
    Catherine M Gliddon
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Prog Neurobiol 75:53-81. 2005
    ....
  100. ncbi Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats
    P M Lenzlinger
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, 105 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Neuroscience 134:1047-56. 2005
    ....
  101. ncbi Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke
    Jane E Warren
    Cognitive Neuroimaging Group, MRC Cyclotron Unit, Hammersmith Hospital, London W120NN, UK
    Brain 132:3428-42. 2009
    ....

Research Grants82

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
    ..Disease/therapy</keyword><keyword>Rats</keyword><keyword>Recovery of Function</keyword><keyword>Seizures/prevention &amp; control</keyword><keyword>*Stem ..
  2. Low-Voltage Nerve Electrophoresis In Vivo: Role in Peripheral Nerve Regeneration
    Roger D Madison; Fiscal Year: 2010
    ..The major key to recovery of function following nerve lesions in the peripheral nervous system is the accurate regeneration of axons to their ..
  3. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2010
    ..would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  4. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  5. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  6. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN KARTJE MD; Fiscal Year: 2009
    ..Project Description Page 6 ..
  7. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2006
    ..of acquisition of motor skills, and could lead to novel methods for inducing, guiding, and assessing recovery of function after spinal cord injury...
  8. Proteasome, protein oxidation, and cardiomyocyte function.
    Xuejun Wang; Fiscal Year: 2010
    ..Cause and effect between proteasome activity, removal of oxidized proteins, and recovery of function will be shown by using a transgenic approach to manipulate proteasome activity...
  9. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2009
    ..Repair of CST connections through reactive sprouting and recovery of function occurs spontaneously after injury, but both are limited...
  10. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2010
    ..Repair of CST connections through reactive sprouting and recovery of function occurs spontaneously after injury, but both are limited...
  11. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2007
    ..Some recovery of function has been demonstrated that has been linked to reorganization within the sensory neocortex and subcortical ..
  12. Metaplasticity and Recovery After Spinal Cord Injury: Cellular Mechanisms
    Adam R Ferguson; Fiscal Year: 2010
    ..Aim 4 tests the therapeutic potential of a TNFa1 inhibitor for promoting use-dependent plasticity and recovery of function after contusive SCI...
  13. Natural History of Muscular & Reflex Changes in Stroke
    MEHDI MIRBAGHERI; Fiscal Year: 2004
    ..the correlation of mechanical abnormalities of spastic limbs with clinical assessment of spasticity and recovery of function. To address the specific aims, a series of perturbation sequences with small amplitudes will be applied to ..
  14. The role of traumatic brain injury stress response on exercise therapy
    GRACE GRIESBACH; Fiscal Year: 2009
    ..sustained stress is likely to decrease BDNF and downstream molecules, some forms of exercise may encumber recovery of function after TBI...
  15. The role of traumatic brain injury stress response on exercise therapy
    Grace Sophia Griesbach; Fiscal Year: 2010
    ..sustained stress is likely to decrease BDNF and downstream molecules, some forms of exercise may encumber recovery of function after TBI...
  16. Intranigral Transplantation in Parkinsonian Monkeys
    Thyagarajan Subramanian; Fiscal Year: 2004
    ..As a corollary, restoration of both nigral and striatal dopamine inputs may produce better recovery of function in Parkinson's disease than restoration of dopamine inputs in the striatum alone...
  17. CHRONIC ADAPTATIONS TO MYOCARDIAL ISCHEMIA
    JOHN CANTY; Fiscal Year: 2000
    ..While some of these dysfunctional states reflect the delayed recovery of function following an cute episode of ischemia or "stunning", others occur without subjective signs of recent ..
  18. Novel Biomarkers for Stroke Injury
    MONIKA OLI; Fiscal Year: 2005
    ..as well as provide information on precise biochemical and molecular mechanisms contributing to injury and recovery of function. We have developed a specific and sensitive biomarker for acute ischemic stroke...
  19. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    Richard E Zigmond; Fiscal Year: 2010
    ..This proposal focuses on identifying molecules that trigger regeneration with the idea that they might be used to enhance regeneration in the periphery and promote regeneration in the central nervous system. ..
  20. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    RICHARD ZIGMOND; Fiscal Year: 2009
    ..This proposal focuses on identifying molecules that trigger regeneration with the idea that they might be used to enhance regeneration in the periphery and promote regeneration in the central nervous system. ..
  21. EFFICACY OF VOICE TREATMENT FOR PARKINSON'S DISEASE
    Lorraine Ramig; Fiscal Year: 2009
    ..propose to continue to develop and refine our treatment model by seeking to understand the neural bases of recovery of function in IPD...
  22. EFFICACY OF VOICE TREATMENT FOR PARKINSON'S DISEASE
    Lorraine Ramig; Fiscal Year: 2007
    ..propose to continue to develop and refine our treatment model by seeking to understand the neural bases of recovery of function in IPD...
  23. Spinal cord injury: plasticity and recovery of function
    Barbara S Bregman; Fiscal Year: 2010
    ..We hypothesize that recovery of function after treatments to increase axonal growth following spinal cord injuries in adult rats is not only due to ..
  24. Axonal growth and guidance for nervous system repair
    George Smith; Fiscal Year: 2009
    ..10 to 20% of patients that undergo surgery to repair traumatic nerve injuries show excellent to very good recovery of function. The high incidence of failed recovery is due to the misrouting of regenerating axons to their targets...
  25. Axonal growth and guidance for nervous system repair
    George Smith; Fiscal Year: 2007
    ..10 to 20% of patients that undergo surgery to repair traumatic nerve injuries show excellent to very good recovery of function. The high incidence of failed recovery is due to the misrouting of regenerating axons to their targets...
  26. TRANSPLANTATION OF HUMAN BONE MARROW STROMAL CELLS
    Itzhak Fischer; Fiscal Year: 2004
    ..phenotype following transplantation into spinal cord and test their ability to promote regeneration and recovery of function. Human MSCs are easy to obtain from a patient under local anesthesia, provide a renewal population and can ..
  27. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    RICHARD ZIGMOND; Fiscal Year: 1990
    This proposal is designed to examine recovery of function after damage to the adult nervous system, using the sympathetic innervation of the rat pineal gland as a model system...
  28. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    Partial recovery of function following a unilateral labyrinthectomy (UL), termed "vestibular compensation," has served as a model for investigations of subcellular investigations of central nervous system plasticity...
  29. Factors Influencing Recovery From Spinal Cord Injury: The Signifiance of Spared S
    Hui Xin Qi; Fiscal Year: 2007
    The prognosis for partial recovery of function after spinal cord injury in humans and other mammals appears to depend largely on the degree of sparing of ascending and descending axons, but the reasons why these preserved axons are ..