recovery of function

Summary

Summary: A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.

Top Publications

  1. doi What do motor "recovery" and "compensation" mean in patients following stroke?
    Mindy F Levin
    School of Physical and Occupational Therapy, McGill University and Center for Interdisciplinary Research in Rehabilitation, Jewish Rehabilitation Hospital, Montreal, Quebec, Canada
    Neurorehabil Neural Repair 23:313-9. 2009
  2. ncbi Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature
    Olivier Ethgen
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Diseases, Department of Public Health, Epidemiology, and Health Economics, University of Liege, Belgium, Liege, Belgium
    J Bone Joint Surg Am 86:963-74. 2004
  3. pmc Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review
    Gert Kwakkel
    Department Rehabilitation Medicine and Research Institute MOVE, VU University Medical Center Amsterdam, The Netherlands
    Neurorehabil Neural Repair 22:111-21. 2008
  4. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
  5. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
  6. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
  7. doi Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand
    Dennis A Nowak
    Department of Neurology, University Hospital, University of Cologne, Cologne, Germany
    Neurorehabil Neural Repair 23:641-56. 2009
  8. ncbi Influence of interhemispheric interactions on motor function in chronic stroke
    Nagako Murase
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 55:400-9. 2004
  9. pmc Neural correlates of outcome after stroke: a cross-sectional fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:1430-48. 2003
  10. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Japan
    Cell 110:429-41. 2002

Detail Information

Publications290 found, 100 shown here

  1. doi What do motor "recovery" and "compensation" mean in patients following stroke?
    Mindy F Levin
    School of Physical and Occupational Therapy, McGill University and Center for Interdisciplinary Research in Rehabilitation, Jewish Rehabilitation Hospital, Montreal, Quebec, Canada
    Neurorehabil Neural Repair 23:313-9. 2009
    ....
  2. ncbi Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature
    Olivier Ethgen
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Diseases, Department of Public Health, Epidemiology, and Health Economics, University of Liege, Belgium, Liege, Belgium
    J Bone Joint Surg Am 86:963-74. 2004
    ..The objective of this study was to review the literature regarding the outcomes of total hip and knee arthroplasties as evaluated by health-related quality-of-life instruments...
  3. pmc Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review
    Gert Kwakkel
    Department Rehabilitation Medicine and Research Institute MOVE, VU University Medical Center Amsterdam, The Netherlands
    Neurorehabil Neural Repair 22:111-21. 2008
    ..The aim of the study was to present a systematic review of studies that investigate the effects of robot-assisted therapy on motor and functional recovery in patients with stroke...
  4. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
    ..These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury...
  5. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
    ..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains...
  6. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..These findings provide a strategy by which individuals with spinal cord injuries could regain substantial levels of motor control...
  7. doi Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand
    Dennis A Nowak
    Department of Neurology, University Hospital, University of Cologne, Cologne, Germany
    Neurorehabil Neural Repair 23:641-56. 2009
    ..This review critically summarizes the data supporting the use of novel electrophysiological concepts in the rehabilitation of hand function after stroke...
  8. ncbi Influence of interhemispheric interactions on motor function in chronic stroke
    Nagako Murase
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 55:400-9. 2004
    ..It is conceivable that this abnormality could adversely influence motor recovery in some patients with subcortical stroke, an interpretation consistent with models of interhemispheric competition in motor and sensory systems...
  9. pmc Neural correlates of outcome after stroke: a cross-sectional fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:1430-48. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear relationship between task-related activation of the motor system and outcome after stroke...
  10. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Japan
    Cell 110:429-41. 2002
    ..These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases...
  11. ncbi Dynamics of language reorganization after stroke
    Dorothee Saur
    Department of Neurology, University Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 129:1371-84. 2006
    ..Thereafter, a normalization of activation is observed, possibly reflecting consolidation in the language system...
  12. pmc Spinal cord injury: a systematic review of current treatment options
    David W Cadotte
    Division of Neurosurgery, University of Toronto, and Neural Repair and Regeneration, Spinal Program, University Health Network, Toronto Western Hospital, Toronto, ON, Canada
    Clin Orthop Relat Res 469:732-41. 2011
    ..Research has revealed an understanding of mechanisms that occur after the primary injury and contribute to functional loss. By targeting these secondary mechanisms of injury, clinicians may be able to offer improved recovery after SCI...
  13. pmc Neural correlates of motor recovery after stroke: a longitudinal fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:2476-96. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear temporal relationship between recovery and task-related activation of the motor system after stroke...
  14. doi Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
    Guillermo Garcia-Alias
    Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
    Nat Neurosci 12:1145-51. 2009
    ..Our results indicate that chondroitinase treatment opens a window during which rehabilitation can promote recovery. However, only the trained skills are improved and other functions may be negatively affected...
  15. ncbi Functional neuroimaging studies of motor recovery after stroke in adults: a review
    Cinzia Calautti
    Department of Neurology, University of Cambridge, Cambrid, UK
    Stroke 34:1553-66. 2003
    ..Reorganization of the motor system after stroke as assessed by functional neuroimaging is an intriguing but challenging new field of research. Provocative but equivocal findings have been reported to date...
  16. doi Robot-assisted therapy for long-term upper-limb impairment after stroke
    Albert C Lo
    Providence Veterans Affairs Medical Center and Brown University, Providence, RI 02909, USA
    N Engl J Med 362:1772-83. 2010
    ..Effective rehabilitative therapies are needed for patients with long-term deficits after stroke...
  17. ncbi Predicting the outcome of total knee arthroplasty
    Elizabeth A Lingard
    Brigham and Women s Hospital, 75 FrancisStreet, Boston, MA 02115, USA
    J Bone Joint Surg Am 86:2179-86. 2004
    ..This paper examines the preoperative predictors of pain and functional outcome at one and two years following total knee arthroplasty...
  18. ncbi Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
    Anthony H Aletras
    National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circulation 113:1865-70. 2006
    ....
  19. ncbi The development of a comorbidity index with physical function as the outcome
    Dianne L Groll
    Department of Surgery, Queen s University, Kingston, Ontario, Canada
    J Clin Epidemiol 58:595-602. 2005
    ..The objective of this study was to develop a self-administered Functional Comorbidity Index with physical function as the outcome...
  20. doi Evidence-based surgical care and the evolution of fast-track surgery
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, Rigshospitalet, Copenhagen, Denmark
    Ann Surg 248:189-98. 2008
    ..Optimization of postoperative outcome requires the application of evidence-based principles of care carefully integrated into a multimodal rehabilitation program...
  21. doi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
    ..The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury...
  22. ncbi Role of adaptive plasticity in recovery of function after damage to motor cortex
    R J Nudo
    Center on Aging and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 5026 Wescoe Pavilion, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Muscle Nerve 24:1000-19. 2001
    ....
  23. ncbi The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08820, USA
    Arch Phys Med Rehabil 85:2020-9. 2004
    ..To determine the measurement properties and diagnostic utility of the JFK Coma Recovery Scale-Revised (CRS-R)...
  24. pmc The John Charnley Award: Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal total hip arthroplasty: a randomized clinical trial
    Donald S Garbuz
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, Room 3114, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, Canada
    Clin Orthop Relat Res 468:318-25. 2010
    ..Level of Evidence: Level I, randomized clinical trial. See Guidelines for Authors for a complete description of levels of evidence...
  25. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
    ....
  26. ncbi The effect of voluntary exercise exposure on histological and neurobehavioral outcomes after ischemic brain injury in the rat
    Raul Marin
    Department of the Army, Walter Reed Army Medical Center, 6900 Georgia Avenue, Washington, DC 20307, USA
    Physiol Behav 80:167-75. 2003
    ....
  27. doi Locomotor training improves daily stepping activity and gait efficiency in individuals poststroke who have reached a "plateau" in recovery
    Jennifer L Moore
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, IL, USA
    Stroke 41:129-35. 2010
    ....
  28. ncbi Analysis of fMRI and finger tracking training in subjects with chronic stroke
    James R Carey
    Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
    Brain 125:773-88. 2002
    ..We concluded that individuals with chronic stroke receiving intensive tracking training showed improved tracking accuracy and grasp and release function, and that these improvements were accompanied by brain reorganization...
  29. ncbi Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the Lokomat gait orthosis
    Andreas Mayr
    Department of Neurology, Hospital Hochzirl, Zirl, Austria
    Neurorehabil Neural Repair 21:307-14. 2007
    ..This prospective, blinded, randomized controlled study of gait retraining tested the feasibility and potential efficacy of using an electromechanical-driven gait orthosis (Lokomat) for treadmill training...
  30. ncbi Targeting recovery: priorities of the spinal cord-injured population
    Kim D Anderson
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 4292, USA
    J Neurotrauma 21:1371-83. 2004
    ..In order to improve the relevance of research in this area, the concerns of the SCI population must be better known and taken into account. This approach is consistent with and emphasized by the new NIH roadmap to discovery...
  31. ncbi The importance of patient expectations in predicting functional outcomes after total joint arthroplasty
    Nizar N Mahomed
    Division of Orthopaedic Surgery, Toronto Western Hospital, University of Toronto, ON, Canada
    J Rheumatol 29:1273-9. 2002
    ..Multivariate regression models were used to evaluate the impact of expectations on outcomes...
  32. ncbi Functional outcome at 2.5, 5, 9, and 24 months after injury in the Netherlands
    Suzanne Polinder
    Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
    J Trauma 62:133-41. 2007
    ..The collection of empirical data on the frequency, severity, and duration of functioning is a prerequisite to identify patient groups with long term or permanent disability...
  33. ncbi Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
    R L Zhang
    Department of Neurology, Henri Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroscience 105:33-41. 2001
    ..From these data we suggest that focal cerebral ischemia induces transient and regional specific increases in cell proliferation in the ipsilateral hemisphere and that proliferating progenitor cells may exist in the adult cortex...
  34. pmc Motor system activation after subcortical stroke depends on corticospinal system integrity
    Nick S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 129:809-19. 2006
    ..Secondary motor regions are less efficient at generating motor output so this reorganization can only be considered partially successful in reducing motor impairment after stroke...
  35. ncbi Rasch analysis of a new stroke-specific outcome scale: the Stroke Impact Scale
    Pamela W Duncan
    Brooks Center for Rehabilitation Studies, University of Florida, Gainesville, FL 32610 0185, USA
    Arch Phys Med Rehabil 84:950-63. 2003
    ..To assess multiple psychometric characteristics of a new stroke outcome measure, the Stroke Impact Scale (SIS), using Rasch analysis, and to identify and remove misfitting items from the 8 domains that comprise the SIS...
  36. ncbi Cell replacement therapies for central nervous system disorders
    A Bjorklund
    The authors are at the Wallenberg Neuroscience Center, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Nat Neurosci 3:537-44. 2000
    ..Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can be developed into effective clinical therapy?..
  37. ncbi Mechanisms of neural plasticity following brain injury
    Tadeusz Wieloch
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, University of Lund, BMCA13, 221 85 Lund, Sweden
    Curr Opin Neurobiol 16:258-64. 2006
    ..These new mechanistic insights are aiding the design of novel therapeutic modalities that enhance regeneration...
  38. doi Motor recovery after stroke: a systematic review
    Peter Langhorne
    Stroke Therapy Evaluation Programme, Academic Section of Geriatric Medicine, Cardiovascular and Medical Sciences Division, Royal Infirmary, Glasgow, UK
    Lancet Neurol 8:741-54. 2009
    ..Although the existing evidence is limited by poor trial designs, some treatments do show promise for improving motor recovery, particularly those that have focused on high-intensity and repetitive task-specific practice...
  39. ncbi The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
    Florence M Bareyre
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 7:269-77. 2004
    ..Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans...
  40. ncbi Health related quality of life outcomes after total hip and knee arthroplasties in a community based population
    C A Jones
    Department of Public Health Sciences, University of Alberta, Edmonton, Canada
    J Rheumatol 27:1745-52. 2000
    ..To quantify the magnitude of change seen with pain, function, and quality of life outcomes 6 months after total hip and knee arthroplasties (THA, TKA) within a community based cohort of a regional health district...
  41. ncbi cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
    Nat Med 10:610-6. 2004
    ..These findings show that cAMP levels are key for protection, growth and myelination of injured CNS axons in vivo and recovery of function.
  42. doi Early exercise in critically ill patients enhances short-term functional recovery
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences CB, BC, CR, DL, TT, RG, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:2499-505. 2009
    ..No evidence is available concerning the effectiveness of an early exercise training intervention to prevent these detrimental complications...
  43. pmc Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke
    Lynne V Gauthier
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Stroke 39:1520-5. 2008
    ..This study evaluated whether evidence could also be found for structural brain changes during an efficacious rehabilitation program...
  44. ncbi Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
    A Ramon-Cueto
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Neuron 25:425-35. 2000
    ..Therefore, OEG transplantation provides a useful repair strategy in adult mammals with traumatic spinal cord injuries. Our results with these cells could lead to new therapies for the treatment of spinal cord lesions in humans...
  45. ncbi The impact of physical therapy on functional outcomes after stroke: what's the evidence?
    R P S Van Peppen
    Department of Physical Therapy, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Rehabil 18:833-62. 2004
    ..To determine the evidence for physical therapy interventions aimed at improving functional outcome after stroke...
  46. ncbi Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1990-2002)
    Bruno Will
    Laboratoire de Neurosciences Comportementales et Cognitives, Institut Fédératif des Neurosciences, Universite Louis Pasteur, UMR 7521, CNRS, Strasbourg, France
    Prog Neurobiol 72:167-82. 2004
    ..Finally, other recent reports emphasize that the treatment parameters may be changed in order to approximate clinical/rehabilitation conditions and, nevertheless, remain effective...
  47. ncbi Understanding the pattern of functional recovery after stroke: facts and theories
    Gert Kwakkel
    Rehabilitation Centre De Hoogstraat, Rudolf Magnus Institute of Neuroscience, NL 3583 UMC Utrecht, The Netherlands
    Restor Neurol Neurosci 22:281-99. 2004
    ....
  48. ncbi Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function
    G S Griesbach
    David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
    Neuroscience 125:129-39. 2004
    ..However, when exercise is administered to soon after TBI, the molecular response to exercise is disrupted and recovery may be delayed...
  49. ncbi Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury
    S Okada
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    J Neurosci Res 76:265-76. 2004
    ..These findings suggest that neutralization of IL-6 signaling in the acute phase of SCI represents an attractive option for the treatment of SCI...
  50. pmc White matter integrity is a stronger predictor of motor function than BOLD response in patients with stroke
    Mingguo Qiu
    Third Military Medical University, Chongqing, China
    Neurorehabil Neural Repair 25:275-84. 2011
    ..This study explores the relationship between upper extremity motor function, white matter integrity, and BOLD response of cortical motor areas...
  51. pmc Motor imagery after stroke: relating outcome to motor network connectivity
    Nikhil Sharma
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Ann Neurol 66:604-16. 2009
    ..This raises an important question: how far does recovery of motor performance depend on the processes that precede movement execution involving the premotor and prefrontal cortex, rather than recovery of the corticospinal system alone?..
  52. doi A three-dimensional reconstruction plate for displaced midshaft fractures of the clavicle
    J W Shen
    Department of Orthopaedic and Traumatic Surgery Zhejiang Province TCM Hospital, Hangzhou 310006, Zheijiang Province, People s Republic of China
    J Bone Joint Surg Br 90:1495-8. 2008
    ..05). If fixation of midshaft fractures of the clavicle with a plate is indicated, a 3D reconstruction plate is better than one placed superiorly, because it is consistent with the stress distribution and shape of the clavicle...
  53. ncbi Neural basis and recovery of spatial attention deficits in spatial neglect
    Maurizio Corbetta
    Department of Neurology, Washington University, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 8:1603-10. 2005
    ....
  54. ncbi Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations
    Birgit Neuhuber
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Brain Res 1035:73-85. 2005
    ..To qualify MSC lots for future clinical application, such notable differences in donor or lot-lot efficacy highlight the need for establishing adequate characterization, including the development of relevant efficacy assays...
  55. pmc Recovery of activities of daily living in older adults after hospitalization for acute medical illness
    Cynthia M Boyd
    Department of Medicine, Division of Geriatric Medicine, School of Medicine, John Hopkins University, Baltimore, Maryland 21224, USA
    J Am Geriatr Soc 56:2171-9. 2008
    ....
  56. doi Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage
    Jeffrey A Kleim
    McKnight Brain Institute, University of Florida, Gainesville, and Brain Rehabilitation Research Center 151A, Malcom Randall VA Hospital, 1610 SW Archer Road, Gainesville, FL 32610, USA
    J Speech Lang Hear Res 51:S225-39. 2008
    ..This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain...
  57. ncbi Plasticity of cortical projections after stroke
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Neuroscientist 9:64-75. 2003
    ..Plasticity within cortical connections after stroke leads to partial recovery of function after the initial injury...
  58. ncbi Reliability of gait performance tests in men and women with hemiparesis after stroke
    Ulla Britt Flansbjer
    Department of Rehabilitation, Lund University Hospital, Lund, Sweden ulla britt
    J Rehabil Med 37:75-82. 2005
    ..Design: An intra-rater (between occasions) test-retest reliability study. Subjects: Fifty men and women (mean age 58+/-6.4 years) 6-46 months post-stroke...
  59. pmc Effectiveness of physiotherapy exercise following hip arthroplasty for osteoarthritis: a systematic review of clinical trials
    Catherine J Minns Lowe
    Department of Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    BMC Musculoskelet Disord 10:98. 2009
    ....
  60. doi Recovery of function in humans: cortical stimulation and pharmacological treatments after stroke
    Agnes Floel
    Department of Neurology, University of Muenster, Germany
    Neurobiol Dis 37:243-51. 2010
    ..Subsequently, we expand on possibilities of adjuvant therapy in human rehabilitation using cortical stimulation and pharmacological treatments. Finally, we suggest future directions for research in this field...
  61. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  62. doi Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke
    Naoyuki Takeuchi
    Department of Rehabilitation Medicine, Hospital of Hokkaido University, Sapporo, Japan
    J Rehabil Med 40:298-303. 2008
    ..We investigated whether 1 Hz rTMS improved the motor learning of the affected hand in patients after stroke...
  63. doi Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
    Steven C Cramer
    Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92868 4280, USA
    Ann Neurol 63:272-87. 2008
    ..Such measures gain importance when viewed as covariates in therapeutic trials of restorative agents that target stroke recovery...
  64. doi Quality of life after stroke: the importance of a good recovery
    Francisco Javier Carod-Artal
    Department of Neurology, Sarah Hospital, The Sarah Network of Rehabilitation Hospitals, Brasilia, Brazil
    Cerebrovasc Dis 27:204-14. 2009
    ..Health-related quality of life (HRQoL) is a recognized and important outcome after stroke. An increased survival and the presence of moderate impairment in long-term stroke survivors impact their HRQoL...
  65. doi Effects of erythropoietin on angiogenesis after myocardial infarction in porcine
    Keisuke Kawachi
    Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama, Kanagawa, 227 8501, Japan
    Heart Vessels 27:79-88. 2012
    ..05) compared with the controls. In conclusion, EPO accelerates angiogenesis via the upregulation of systemic levels such as HGF and FGF, and the local expression of VEGF and IGF, in porcine MI...
  66. pmc Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment
    Zhongwu Liu
    Neurology Research, E and R Building, Room 3056, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Stroke 39:2571-7. 2008
    ..We investigated contralesional corticospinal tract remodeling in the brain and spinal cord in rats after stroke and treatment of bone marrow stromal cells...
  67. ncbi New treatments in neurorehabilitation founded on basic research
    Edward Taub
    Birmingham Veterans Affairs Medical Center and Department of Psychology, University of Alabama at Birmingham, CPM 712, 1530 3rd Avenue South, Birmingham, Alabama 35294 0018, USA
    Nat Rev Neurosci 3:228-36. 2002
    ..The ongoing changes in rehabilitation strategies might well amount to an impending paradigm shift in this field...
  68. ncbi Functional MRI detects posterior shifts in primary sensorimotor cortex activation after stroke: evidence of local adaptive reorganization?
    R Pineiro
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, UK
    Stroke 32:1134-9. 2001
    ..Here, we have tested for potentially adaptive reorganization in the primary sensorimotor cortex...
  69. doi Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI, USA
    Neurobiol Dis 34:113-20. 2009
    ..Our results argue that SBMA may be caused by AR acting in muscle...
  70. doi Functional neuroimaging studies of early upper limb recovery after stroke: a systematic review of the literature
    Floor E Buma
    Rudolf Magnus Institute of Neuroscience, Department of Rehabilitation and Sports Medicine, University Medical Centre Utrecht, Utrecht, Netherlands
    Neurorehabil Neural Repair 24:589-608. 2010
    ..Imaging techniques such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) allow changes in brain activity after stroke recovery to be identified...
  71. doi Effects of rehabilitative training and anti-inflammatory treatment on functional recovery and cellular reorganization following stroke
    Susan Liebigt
    Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, D 07747 Jena, Germany
    Exp Neurol 233:776-82. 2012
    ....
  72. doi Enriched environment promotes efficiency of compensatory movements after cerebral ischemia in rats
    M Knieling
    Hans Berger Clinic of Neurology, Friedrich Schiller University, 07740 Jena, Germany
    Neuroscience 163:759-69. 2009
    ..Enriched environment provides benefit by increased motor activity mainly due to compensation. Furthermore, these findings emphasize the power of comprehensive movement analysis to gain insight into recovery processes after stroke...
  73. ncbi Patient expectations regarding total knee arthroplasty: differences among the United States, United kingdom, and Australia
    Elizabeth A Lingard
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Bone Joint Surg Am 88:1201-7. 2006
    ....
  74. pmc Promoting axonal rewiring to improve outcome after stroke
    Larry I Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Program, Children s Hospital, USA
    Neurobiol Dis 37:259-66. 2010
    ..These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke...
  75. ncbi Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer
    N S Abraham
    Surgical Outcomes Research Centre, Central Sydney Area Health Service, University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Br J Surg 91:1111-24. 2004
    ..The safety and efficacy of laparoscopic resection (LR) for colorectal cancer remains to be established...
  76. doi Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1254:10-7. 2009
    ..Even a modest improvement in nerve regeneration could have significant clinical implications for reconstructive nerve surgery...
  77. pmc Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors
    K Fouad
    Centre for Neuroscience, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    J Neurophysiol 104:2975-84. 2010
    ..Thus while normal rats can compensate for loss of 5-HT(2) receptor activity, after severe spinal cord injury rats require constitutive activity in these 5-HT(2) receptors to produce locomotion...
  78. ncbi The prognostic value of domain-specific cognitive abilities in acute first-ever stroke
    G M S Nys
    Psychological Laboratory, Utrecht University, Heidelberglaan 2, 3584 CS Utrecht, The Netherlands
    Neurology 64:821-7. 2005
    ..To evaluate the prognostic value of domain-specific cognitive abilities in acute stroke with respect to long-term cognitive and functional outcome in addition to neurologic and demographic predictors...
  79. ncbi The relationship of anticipated pain and fear avoidance beliefs to outcome in patients with chronic low back pain who are not receiving workers' compensation
    Saud M Al-Obaidi
    Department of Physical Therapy, Kuwait University, Faculty of Allied Health Sciences and Nursing, Sulaibikhat, Kuwait
    Spine (Phila Pa 1976) 30:1051-7. 2005
    ..A prospective, interventional case series design...
  80. ncbi Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery
    J Girgis
    McGill University, Centre for Neuronal Survival, Montreal, Canada
    Brain 130:2993-3003. 2007
    ....
  81. doi Compensatory changes at the cerebral cortical level after spinal cord injury
    Yukio Nishimura
    From the Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Neuroscientist 15:436-44. 2009
    ..These changes in the activation pattern of motor-related areas represent an adaptive strategy for functional compensation after spinal cord injury...
  82. ncbi Indirect reduction and percutaneous fixation versus open reduction and internal fixation for displaced intra-articular fractures of the distal radius: a randomised, controlled trial
    H J Kreder
    Division of Orthopaedics, University of Toronto, Ontario M4N 3M5, Canada
    J Bone Joint Surg Br 87:829-36. 2005
    ....
  83. pmc Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke
    R Lindenberg
    Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Neurology 74:280-7. 2010
    ....
  84. ncbi Epidemiology of renal recovery after acute renal failure
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Curr Opin Crit Care 12:544-50. 2006
    ..Herein, the epidemiology of renal recovery after acute renal failure will be described, along with potential predictive factors and interventions...
  85. ncbi Ependymal cell reactions in spinal cord segments after compression injury in adult rat
    Masaki Takahashi
    Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
    J Neuropathol Exp Neurol 62:185-94. 2003
    ....
  86. doi Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery
    Yona Goldshmit
    Centre for Neuroscience, School of Physiotherapy, University of Melbourne, Melbourne, Australia
    J Neurotrauma 25:449-65. 2008
    ..However, there was no axonal regeneration into or across the lesion site indicating that the improved behaviour may have been, at least in part, due to enhanced neural activity above the lesion site...
  87. ncbi Time course of trunk, arm, leg, and functional recovery after ischemic stroke
    Geert Verheyden
    Katholieke Universiteit Leuven, Department of Rehabilitation Sciences, Leuven, Belgium
    Neurorehabil Neural Repair 22:173-9. 2008
    ..Patterns of recovery provide useful information concerning the potential of physical recovery over time and therefore the setting of realistic goals for rehabilitation programs...
  88. pmc Prediction of global left ventricular functional recovery in patients with heart failure undergoing surgical revascularisation, based on late gadolinium enhancement cardiovascular magnetic resonance
    Tammy J Pegg
    University of Oxford Centre for Clinical Magnetic Resonance Research, UK
    J Cardiovasc Magn Reson 12:56. 2010
    ..Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...
  89. ncbi Neglect treatment by prism adaptation: what recovers and for how long
    Andrea Serino
    Dipartimento di Psicologia, Universita di Bologna, Bologna, Italy
    Neuropsychol Rehabil 17:657-87. 2007
    ....
  90. doi Stroke in the very old: incidence, risk factors, clinical features, outcomes and access to resources--a 22-year population-based study
    Yannick Bejot
    Stroke Registry of Dijon Inserm et Institut de Veille Sanitaire, EA4184, University Hospital and Faculty of Medicine and Department of Neurology, Dijon, France ybejot yahoo fr
    Cerebrovasc Dis 29:111-21. 2010
    ..For several years, the burden of stroke in very old patients has been increasing in western countries. Nevertheless, we have little information about this new challenge in individuals >or=80...
  91. ncbi Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury
    Akiyuki Hiraga
    Department of Neurobiology, Chiba University Graduate School of Medicine, Chiba, Japan
    J Peripher Nerv Syst 11:217-24. 2006
    ..In addition, fasudil does not suppress the myelination of regenerating axons. These findings suggest that RhoA/Rho-kinase may be a practical molecular target to enhance axonal regeneration in human peripheral neuropathies...
  92. ncbi Use of the reverse shoulder prosthesis for the treatment of failed hemiarthroplasty in patients with glenohumeral arthritis and rotator cuff deficiency
    J C Levy
    Orthopaedic Institute at Holy Cross, Fort Lauderdale, Florida 33308, USA
    J Bone Joint Surg Br 89:189-95. 2007
    ..However, high rates of complications were associated with glenoid and proximal humeral bone loss...
  93. ncbi Predicting mobility outcome one year after stroke: a prospective cohort study
    Ingrid G L van de Port
    Centre of Excellence for Rehabilitation Medicine Utrecht, Rehabilitation Centre De Hoogstraat, Utrecht, The Netherlands
    J Rehabil Med 38:218-23. 2006
    ..To develop a prognostic model to predict mobility outcome one year post-stroke...
  94. ncbi Improvements in speed-based gait classifications are meaningful
    Arlene Schmid
    Department of Occupational Therapy, Indiana University School of Health and Rehabilitation Sciences, and the Richard L Roudebush VA Medical Center, Indianapolis, IN 46202 5119, USA
    Stroke 38:2096-100. 2007
    ..8 m/s). The purpose of the current study was to determine whether changes in velocity-based community ambulation classification were related to clinically meaningful changes in stroke-related function and quality of life...
  95. ncbi Virtual reality in stroke rehabilitation: a systematic review of its effectiveness for upper limb motor recovery
    Amy Henderson
    Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Top Stroke Rehabil 14:52-61. 2007
    ..One intervention showing promise is virtual reality (VR), using either immersive or nonimmersive technology. Before recommending VR for use in clinical practice, it is important to understand the evidence regarding its effectiveness...
  96. pmc An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
    Songlin Li
    Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Nat Neurosci 13:1496-504. 2010
    ..This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery...
  97. ncbi Syndesmotic screw fixation in Weber C ankle injuries--should the screw be removed before weight bearing?
    David Paul Bell
    Department of Orthopaedic Surgery, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Republic of Singapore
    Injury 37:891-8. 2006
    ..To compare the outcomes of Weber C ankle fractures treated with syndesmotic screw fixation where the screw was removed prior to weight bearing against those where the screw was left in situ indefinitely...
  98. ncbi Trunk control as an early predictor of comprehensive activities of daily living function in stroke patients
    Ching lin Hsieh
    School of Occupational Therapy, College of Medicine, National Taiwan University, Republic of China
    Stroke 33:2626-30. 2002
    ..The objective of this study was to assess the relationship between trunk control at an early stage and comprehensive ADL function (as assessed by combining basic ADL and instrumental ADL [IADL]) in patients at 6 months after stroke...
  99. ncbi The relationship between admission hemoglobin level and outcome after hip fracture
    Konrad I Gruson
    Geriatric Hip Fracture Research Group, Department of Orthopaedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003, USA
    J Orthop Trauma 16:39-44. 2002
    ..To determine the effect of admission hemoglobin level on patient outcome after hip fracture...
  100. doi Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury
    Stephanie Lord-Fontaine
    BioAxone Therapeutic Inc, Montreal, Quebec, Canada
    J Neurotrauma 25:1309-22. 2008
    ..Rats gained body weight normally, and BA-210 treatment had no impact on the development of allodynia. Inactivating Rho with BA-210 holds promise for treating patients with SCI...
  101. ncbi Tricortical versus quadricortical syndesmosis fixation in ankle fractures: a prospective, randomized study comparing two methods of syndesmosis fixation
    Per Høiness
    Ullevaal University Hospital, Oslo, Norway
    J Orthop Trauma 18:331-7. 2004
    ..To assess short-term functional results in 2 types of syn-desmotic fixation, comparing the traditional rigid quadricortical syndesmotic screw fixation with a more dynamic tricortical screw fixation...

Research Grants82

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
    ..Disease/therapy</keyword><keyword>Rats</keyword><keyword>Recovery of Function</keyword><keyword>Seizures/prevention &amp; control</keyword><keyword>*Stem ..
  2. Low-Voltage Nerve Electrophoresis In Vivo: Role in Peripheral Nerve Regeneration
    Roger D Madison; Fiscal Year: 2010
    ..The major key to recovery of function following nerve lesions in the peripheral nervous system is the accurate regeneration of axons to their ..
  3. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2010
    ..would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  4. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  5. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  6. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN KARTJE MD; Fiscal Year: 2009
    ..Project Description Page 6 ..
  7. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2006
    ..of acquisition of motor skills, and could lead to novel methods for inducing, guiding, and assessing recovery of function after spinal cord injury...
  8. Proteasome, protein oxidation, and cardiomyocyte function.
    Xuejun Wang; Fiscal Year: 2010
    ..Cause and effect between proteasome activity, removal of oxidized proteins, and recovery of function will be shown by using a transgenic approach to manipulate proteasome activity...
  9. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2009
    ..Repair of CST connections through reactive sprouting and recovery of function occurs spontaneously after injury, but both are limited...
  10. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2010
    ..Repair of CST connections through reactive sprouting and recovery of function occurs spontaneously after injury, but both are limited...
  11. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2007
    ..Some recovery of function has been demonstrated that has been linked to reorganization within the sensory neocortex and subcortical ..
  12. Metaplasticity and Recovery After Spinal Cord Injury: Cellular Mechanisms
    Adam R Ferguson; Fiscal Year: 2010
    ..Aim 4 tests the therapeutic potential of a TNFa1 inhibitor for promoting use-dependent plasticity and recovery of function after contusive SCI...
  13. Natural History of Muscular & Reflex Changes in Stroke
    MEHDI MIRBAGHERI; Fiscal Year: 2004
    ..the correlation of mechanical abnormalities of spastic limbs with clinical assessment of spasticity and recovery of function. To address the specific aims, a series of perturbation sequences with small amplitudes will be applied to ..
  14. The role of traumatic brain injury stress response on exercise therapy
    GRACE GRIESBACH; Fiscal Year: 2009
    ..sustained stress is likely to decrease BDNF and downstream molecules, some forms of exercise may encumber recovery of function after TBI...
  15. The role of traumatic brain injury stress response on exercise therapy
    Grace Sophia Griesbach; Fiscal Year: 2010
    ..sustained stress is likely to decrease BDNF and downstream molecules, some forms of exercise may encumber recovery of function after TBI...
  16. CHRONIC ADAPTATIONS TO MYOCARDIAL ISCHEMIA
    JOHN CANTY; Fiscal Year: 2000
    ..While some of these dysfunctional states reflect the delayed recovery of function following an cute episode of ischemia or "stunning", others occur without subjective signs of recent ..
  17. Novel Biomarkers for Stroke Injury
    MONIKA OLI; Fiscal Year: 2005
    ..as well as provide information on precise biochemical and molecular mechanisms contributing to injury and recovery of function. We have developed a specific and sensitive biomarker for acute ischemic stroke...
  18. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    RICHARD ZIGMOND; Fiscal Year: 2009
    ..This proposal focuses on identifying molecules that trigger regeneration with the idea that they might be used to enhance regeneration in the periphery and promote regeneration in the central nervous system. ..
  19. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    Richard E Zigmond; Fiscal Year: 2010
    ..This proposal focuses on identifying molecules that trigger regeneration with the idea that they might be used to enhance regeneration in the periphery and promote regeneration in the central nervous system. ..
  20. EFFICACY OF VOICE TREATMENT FOR PARKINSON'S DISEASE
    Lorraine Ramig; Fiscal Year: 2009
    ..propose to continue to develop and refine our treatment model by seeking to understand the neural bases of recovery of function in IPD...
  21. EFFICACY OF VOICE TREATMENT FOR PARKINSON'S DISEASE
    Lorraine Ramig; Fiscal Year: 2007
    ..propose to continue to develop and refine our treatment model by seeking to understand the neural bases of recovery of function in IPD...
  22. Spinal cord injury: plasticity and recovery of function
    Barbara S Bregman; Fiscal Year: 2010
    ..We hypothesize that recovery of function after treatments to increase axonal growth following spinal cord injuries in adult rats is not only due to ..
  23. Axonal growth and guidance for nervous system repair
    George Smith; Fiscal Year: 2009
    ..10 to 20% of patients that undergo surgery to repair traumatic nerve injuries show excellent to very good recovery of function. The high incidence of failed recovery is due to the misrouting of regenerating axons to their targets...
  24. Axonal growth and guidance for nervous system repair
    George Smith; Fiscal Year: 2007
    ..10 to 20% of patients that undergo surgery to repair traumatic nerve injuries show excellent to very good recovery of function. The high incidence of failed recovery is due to the misrouting of regenerating axons to their targets...
  25. Intranigral Transplantation in Parkinsonian Monkeys
    Thyagarajan Subramanian; Fiscal Year: 2004
    ..As a corollary, restoration of both nigral and striatal dopamine inputs may produce better recovery of function in Parkinson's disease than restoration of dopamine inputs in the striatum alone...
  26. TRANSPLANTATION OF HUMAN BONE MARROW STROMAL CELLS
    Itzhak Fischer; Fiscal Year: 2004
    ..phenotype following transplantation into spinal cord and test their ability to promote regeneration and recovery of function. Human MSCs are easy to obtain from a patient under local anesthesia, provide a renewal population and can ..
  27. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    RICHARD ZIGMOND; Fiscal Year: 1990
    This proposal is designed to examine recovery of function after damage to the adult nervous system, using the sympathetic innervation of the rat pineal gland as a model system...
  28. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    Partial recovery of function following a unilateral labyrinthectomy (UL), termed "vestibular compensation," has served as a model for investigations of subcellular investigations of central nervous system plasticity...
  29. Factors Influencing Recovery From Spinal Cord Injury: The Signifiance of Spared S
    Hui Xin Qi; Fiscal Year: 2007
    The prognosis for partial recovery of function after spinal cord injury in humans and other mammals appears to depend largely on the degree of sparing of ascending and descending axons, but the reasons why these preserved axons are ..