insensible water loss

Summary

Summary: Loss of water by diffusion through the skin and by evaporation from the respiratory tract.

Top Publications

  1. ncbi Effect of exposure of human skin to a dry environment
    Mariko Egawa
    Shiseido Research Center Shin Yokohama, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Skin Res Technol 8:212-8. 2002
  2. ncbi Effects of moisturization on epidermal homeostasis and differentiation
    R W Short
    Department of Dermatology, Malcolm Grow Medical Center, MD, USA
    Clin Exp Dermatol 32:88-90. 2007
  3. ncbi Impact of anatomical location on barrier recovery, surface pH and stratum corneum hydration after acute barrier disruption
    J W Fluhr
    San Gallicano Dermatological Institute, Rome, Italy
    Br J Dermatol 146:770-6. 2002
  4. ncbi Cling wrap, an innovative intervention for temperature maintenance and reduction of insensible water loss in very low-birthweight babies nursed under radiant warmers: a randomized, controlled trial
    M Kaushal
    Neonatal Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
    Ann Trop Paediatr 25:111-8. 2005
  5. ncbi Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models
    Joachim W Fluhr
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Germany
    Exp Dermatol 15:483-92. 2006
  6. ncbi Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm)
    M Loden
    Research and Development, ACO HUD AB, Box 542, S 18215 Danderyd, Stockholm, Sweden
    Br J Dermatol 140:264-7. 1999
  7. ncbi Effect of semipermeable membranes on skin barrier repair following tape stripping
    M Visscher
    The Skin Sciences Institute, Children s Hospital Research Foundation, The University of Cincinnati, Ohio, USA
    Arch Dermatol Res 293:491-9. 2001
  8. ncbi Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate
    C M de Jongh
    Coronel Institute for Occupational and Environmental Health, AmCOGG, Academic Medical Centre, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Br J Dermatol 154:651-7. 2006
  9. ncbi A closed unventilated chamber for the measurement of transepidermal water loss
    Jouni Nuutinen
    Department of Applied Physics, University of Kuopio, Kuopio, Finland
    Skin Res Technol 9:85-9. 2003
  10. ncbi The clinical benefit of moisturizers
    M Loden
    ACO HUD AB, Stockholm, Sweden
    J Eur Acad Dermatol Venereol 19:672-88; quiz 686-7. 2005

Detail Information

Publications158 found, 100 shown here

  1. ncbi Effect of exposure of human skin to a dry environment
    Mariko Egawa
    Shiseido Research Center Shin Yokohama, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Skin Res Technol 8:212-8. 2002
    ..We have examined the effect of low humidity on healthy human skin by using noninvasive measurement devices...
  2. ncbi Effects of moisturization on epidermal homeostasis and differentiation
    R W Short
    Department of Dermatology, Malcolm Grow Medical Center, MD, USA
    Clin Exp Dermatol 32:88-90. 2007
    ..004). Even nonxerotic, photoaged skin may appear younger, benefiting structurally and functionally from routine use of moisturizers containing dimethicone and glycerine...
  3. ncbi Impact of anatomical location on barrier recovery, surface pH and stratum corneum hydration after acute barrier disruption
    J W Fluhr
    San Gallicano Dermatological Institute, Rome, Italy
    Br J Dermatol 146:770-6. 2002
    ..It is not known whether distinct anatomical locations will respond with different recovery rates following acute barrier challenges...
  4. ncbi Cling wrap, an innovative intervention for temperature maintenance and reduction of insensible water loss in very low-birthweight babies nursed under radiant warmers: a randomized, controlled trial
    M Kaushal
    Neonatal Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
    Ann Trop Paediatr 25:111-8. 2005
    ..The value of polythene film ('cling wrap') to improve thermal control and reduce postnatal weight loss in preterm, very low-birthweight babies was investigated...
  5. ncbi Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models
    Joachim W Fluhr
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Germany
    Exp Dermatol 15:483-92. 2006
    ..Together, these results verify the utility of TEWL as a measure of permeability barrier status. Moreover, all tested instruments are reliable tools for the assessment of variations in permeability barrier function...
  6. ncbi Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm)
    M Loden
    Research and Development, ACO HUD AB, Box 542, S 18215 Danderyd, Stockholm, Sweden
    Br J Dermatol 140:264-7. 1999
    ..05). Thus, it seems that certain moisturizers could improve skin barrier function in atopics and reduce skin susceptibility to irritants. The mechanism and the clinical relevance need further investigation...
  7. ncbi Effect of semipermeable membranes on skin barrier repair following tape stripping
    M Visscher
    The Skin Sciences Institute, Children s Hospital Research Foundation, The University of Cincinnati, Ohio, USA
    Arch Dermatol Res 293:491-9. 2001
    ..The choice of wound dressing is discussed within the larger context of the design of vapor-permeable fabrics (smart materials) and the new fields of corneotherapy and comfort science...
  8. ncbi Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate
    C M de Jongh
    Coronel Institute for Occupational and Environmental Health, AmCOGG, Academic Medical Centre, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Br J Dermatol 154:651-7. 2006
    ..A difference in the skin barrier to SLS may contribute to this variation. To date, no human in vivo data have been available on SLS penetration into the skin...
  9. ncbi A closed unventilated chamber for the measurement of transepidermal water loss
    Jouni Nuutinen
    Department of Applied Physics, University of Kuopio, Kuopio, Finland
    Skin Res Technol 9:85-9. 2003
    ..Additionally, in order to use the evaporimeter to measure evaporation rates through other biological and non-biological specimens and in the field applications, a small portable, battery-operated device was a design criteria...
  10. ncbi The clinical benefit of moisturizers
    M Loden
    ACO HUD AB, Stockholm, Sweden
    J Eur Acad Dermatol Venereol 19:672-88; quiz 686-7. 2005
    ..Patients and the society expect dermatologists and pharmacists to be able to recommend treatment for various dry skin conditions upon evidence-based medicine...
  11. ncbi Changes in basal cell mitosis and transepidermal water loss in skin cultures treated with vitamins C and E
    W E Parish
    Unilever Corporate Research, Colworth, Sharnbrook, Bedford, UK
    Exp Dermatol 14:684-91. 2005
    ..Vitamin E at 20 and 40 microM did not. Both vitamins reduced TEWL providing functional data in support of previous reports on barrier properties. These are functional biomarkers of skin benefit relevant to skin in vivo...
  12. ncbi Characterization of surfactant-induced skin damage through barrier recovery induced by pseudoacylceramides
    Yutaka Takagi
    Department of Dermatology, Jichi Medical University, Tochigi, Japan
    Dermatology 211:128-34. 2005
    ..To determine how much barrier-reinforcing effects of ceramides contribute to prevent the surfactant-induced cutaneous deterioration...
  13. ncbi Long-term repetitive sodium lauryl sulfate-induced irritation of the skin: an in vivo study
    Nara Branco
    Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143 0989, USA
    Contact Dermatitis 53:278-84. 2005
    ..Alternative models should be developed to prove or disprove the accommodation hypothesis...
  14. ncbi Clinically normal atopic skin vs. non-atopic skin as seen through electrical impedance
    Ingrid Nicander
    Department of Dermatology I 43, Huddinge University Hospital, Huddinge, Sweden
    Skin Res Technol 10:178-83. 2004
    ..We looked at the same time at concomitant alterations in transepidermal water loss (TEWL) and skin moisture results...
  15. ncbi Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders
    Marie Lodén
    ACO HUD AB, Stockholm, Sweden
    Am J Clin Dermatol 4:771-88. 2003
    ..The chemistry and function of dry skin and moisturizers is a challenging subject for the practicing dermatologist, as well as for the chemist developing these agents in the pharmaceutical/cosmetic industry...
  16. ncbi The correlation between transepidermal water loss and percutaneous absorption: an overview
    Jackie Levin
    Department of Dermatology, University of California School of Medicine, 90 Medical Center Way, Surge 110, San Francisco, CA 94143, USA
    J Control Release 103:291-9. 2005
    ..Experiments to discern a quantitative and/or qualitative correlation between the two indicators have resulted in controversy. This paper reviews some major studies investigating this correlation...
  17. ncbi The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease
    Jeffrey L Sugarman
    Departments of Dermatology, University of California, San Francisco 94115, USA
    Arch Dermatol 139:1417-22. 2003
    ..The aim of this study was to develop an objective measure of AD severity by measuring stratum corneum (SC) functions and by using computer-assisted estimates of involved body surface areas (BSAs)...
  18. ncbi Artificial disruption of skin barrier prior to irritant patch testing does not improve test design
    K L Gebhard
    Department of Dermatology, Philipp University of Marburg, Deutschhausstr 9, D 35033 Marburg, Germany
    Br J Dermatol 150:82-9. 2004
    ..Irritant patch testing is often performed as a 24- or 48-h occlusive patch test with low concentrations of sodium lauryl sulphate (SLS)...
  19. ncbi Do osmotic forces play a role in the uptake of water by human skin?
    Patricia M van Kemenade
    Personal Care Institute, Philips Research, Eindhoven, The Netherlands
    Skin Res Technol 10:109-12. 2004
    ..To assess the influence of osmotic forces on the water uptake of the skin, we investigated transient TEWL values after 1 h application of salt solutions of different molarities (0, 1, and 4 M NaCl)...
  20. ncbi On the course of the irritant reaction after irritation with sodium lauryl sulphate
    Max Gloor
    Department of Dermatology Municipal Hospital Karlsruhe GmbH, Germany
    Skin Res Technol 10:144-8. 2004
    ..The sodium lauryl sulphate (SLS) irritation test is a well-established model for irritant contact dermatitis after the effects of surfactants...
  21. ncbi Intra-individual variation of irritant threshold and relationship to transepidermal water loss measurement of skin irritation
    H R Smith
    Contact Dermatitis Clinic, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Contact Dermatitis 51:26-9. 2004
    ..The variation seen may reflect the different outcomes measured: irritant threshold visually assesses the skin inflammatory response while TEWL measures skin barrier modification...
  22. ncbi The "strip" patch test: results of a multicentre study towards a standardization
    Heinrich Dickel
    Department of Dermatology, Environmental Medicine, and Health Theory, University of Osnabruck, Sedanstr 115, 49090 Osnabrück, Germany
    Arch Dermatol Res 296:212-9. 2004
    ..Penetration of the substances is enhanced by repeated applications of adhesive tape prior to their application to the skin. However, no guidelines exist for standardized performance of the SPT...
  23. ncbi Stratum corneum adhesive tape stripping: influence of anatomical site, application pressure, duration and removal
    H Loffler
    Department of Dermatology, University of California, San Francisco, CA, USA
    Br J Dermatol 151:746-52. 2004
    ..Tape stripping is a common method for investigating stratum corneum (SC) physiology as well as bioavailability and bioequivalence of topical drugs...
  24. ncbi Exploring the influence of skin perfusion on transepidermal water loss
    Luis Monteiro Rodrigues
    Lisbon s University School of Pharmacy, Lab Experimental Physiology UCTF, Lisboa, Portugal
    Skin Res Technol 10:257-62. 2004
    ....
  25. ncbi Transdermal suctioning technique for serial sampling of interstitial fluid in newborn infants
    I Hansen-Pupp
    Department of Paediatrics, University Hospital, Lund, Sweden
    Biol Neonate 87:197-202. 2005
    ..Use of a suction-induced epidermal mini-erosion for serial sampling of dermal interstitial fluid (IF) in 16 newborn infants with gestational age ranging from 24 to 42 weeks is reported...
  26. ncbi Regional difference of water content in human skin studied by diffuse-reflectance near-infrared spectroscopy: consideration of measurement depth
    Mariko Egawa
    Shiseido Research Center Shin Yokohama, Yokohama 224 8558, Japan
    Appl Spectrosc 60:24-8. 2006
    ....
  27. ncbi Impairment of skin barrier function is not inherent in atopic dermatitis patients: a prospective study conducted in newborns
    Katsuko Kikuchi
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pediatr Dermatol 23:109-13. 2006
    ..Therefore, we concluded that the barrier impairment found in atopic dermatitis is not inherent but represents a phenomenon secondary to dermatitic skin changes...
  28. ncbi Skin barrier function and the use of emollients in dermatological nursing
    Sandra Lawton
    Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Br J Nurs 16:712, 714, 716, 718-9. 2007
    ..This article explores the barrier function of the skin, factors which influence skin barrier function and the use of emollients for dry skin and skin conditions...
  29. ncbi Effects of disinfectants and detergents on skin irritation
    Caroline M Slotosch
    Department of Dermatology, Philipp University, Marburg, Germany
    Contact Dermatitis 57:235-41. 2007
    ..Our study shows that there is no summation of irritating effects of a common detergent and propanol and that the combination of washing and disinfection has a rather protective aspect compared with washing alone...
  30. ncbi Qualitative and quantitative comparison of heat separated epidermis and dermatomed skin in percutaneous absorption studies
    Nicolas Atrux-Tallau
    Laboratoire de Recherche et Développement de Pharmacie Galénique Industrielle, Faculte de Pharmacie, Fonctions normales et pathologiques de la barrière cutanée, Universite Lyon 1, Lyon Cedex 08, France
    Arch Dermatol Res 299:507-11. 2007
    ....
  31. ncbi [Survey of atopic dermatitis and skin barrier functions in Japanese and Chinese school students]
    Yasuyuki Sumikawa
    Department of Dermatology, Toyonaka Municipal Hospital, Japan
    Arerugi 56:1270-5. 2007
    ..The comparative studies of the prevalence of atopic dermatitis and skin barrier functions in Japanese and Chinese were performed...
  32. ncbi Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate
    Viswatej Vemulapalli
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
    J Pharm Pharmacol 60:27-33. 2008
    ..A synergistic 25-fold enhancement of delivery was observed in-vivo when a combination of microneedles and ionto- phoresis was used compared with either modality alone...
  33. doi Protection effect of cosmetics on human skin under simulated rigorous environment
    Yan Cheng
    Beijing Sino German Union Cosmetic Institute Co, Chinese Academy of Inspection and Quarantine, Beijing, China
    Skin Res Technol 14:45-52. 2008
    ..The aim of this study was to develop a model for the evaluation of the efficacy of cosmetics on human skin under simulated rigorous environment...
  34. doi The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method
    Patricia García Ortiz
    Department of Dermatology, Gentofte Hospital, 2900 Hellerup, Denmark
    Contact Dermatitis 59:23-30. 2008
    ..Determination of drug penetration in diseased skin represents a challenge...
  35. ncbi Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
    Huey Chun Huang
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Int J Dermatol 47:812-9. 2008
    ..Aim To evaluate the potential water retention capacity of control emulsion and three oil-in-water (o/w) emulsions containing ceramide 1, ceramide 3, or both...
  36. ncbi Assessment of atopic eczema: clinical scoring and noninvasive measurements
    E A Holm
    Division of Dermatology, Department of Medicine, Roskilde Hospital, University of Copenhagen, Koegevej 7 13, D 4000 Roskilde, Denmark
    Br J Dermatol 157:674-80. 2007
    ..Few studies are available of the association between clinical scores and instrumental assessment of disease severity obtained with noninvasive instruments...
  37. ncbi Functional assessment of a skin care system in patients on chemotherapy
    J W Fluhr
    Skin Physiology Laboratory, Friedrich Schiller University, Jena, Germany
    Skin Pharmacol Physiol 20:253-9. 2007
    ..The aim of this study was to verify whether a concomitant treatment with an acidic washing and an acidic emollient (both pH 5.5) can significantly improve the quality of the skin in such patients...
  38. ncbi Taurine improves epidermal barrier properties stressed by surfactants-a role for osmolytes in barrier homeostasis
    Bernd Anderheggen
    Henkel KGaA, Henkelstrasse 67, 40191 Duesseldorf, Germany
    J Cosmet Sci 57:1-10. 2006
    ..In conclusion, our data suggest a role for taurine in preventing surfactant-induced dry and scaly skin by modulating the proinflammatory response and stimulating epidermal lipid synthesis...
  39. ncbi Skin capacitance imaging and corneosurfametry. A comparative assessment of the impact of surfactants on stratum corneum
    Emmanuelle Xhauflaire-Uhoda
    Departement of Dermatopathology, University Hospital of Liege, Belgium
    Contact Dermatitis 54:249-53. 2006
    ..The SkinChip image changes likely corresponded to the acute surfactant-induced water swelling of the corneocytes. Skin capacitance imaging and corneosurfametry allow to disclose discrete surfactant-induced alterations of corneocytes...
  40. ncbi Correlation of clinical features and skin barrier function in adolescent and adult patients with atopic dermatitis
    Do Won Kim
    Department of Dermatology, Kyungpook National University School of Medicine, Daegu, South Korea
    Int J Dermatol 45:698-701. 2006
    ..Noninvasive bioengineering methods, including the measurement of the transepidermal water loss (TEWL) and water capacitance, have been commonly used to evaluate skin barrier function...
  41. ncbi Concepts in skin care maintenance
    Zoe Diana Draelos
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cutis 76:19-25. 2005
    ....
  42. ncbi Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques
    Susi Elaine Dal'Belo
    Laboratory of Cosmetic Technology, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, University of Sao Paulo, Brazil
    Skin Res Technol 12:241-6. 2006
    ....
  43. ncbi Instrumental assessment of atopic eczema: validation of transepidermal water loss, stratum corneum hydration, erythema, scaling, and edema
    Elisabeth A Holm
    Department of Dermatology at Roskilde Hospital, Copenhagen University, Denmark
    J Am Acad Dermatol 55:772-80. 2006
    ..Quantification of skin diseases can be carried out in many ways. Clinical scores are widely used in atopic eczema (AE), and noninvasive instruments are a relevant supplement...
  44. doi Lipids and skin barrier function--a clinical perspective
    Jakob Mutanu Jungersted
    Department of Dermatology, Roskilde Hospital, University of Copenhagen, Køgevej 7 13, DK 4000 Roskilde, Denmark
    Contact Dermatitis 58:255-62. 2008
    ..It may be concluded that the number of human studies is very limited, and in the perspective of how important diseases of impaired barrier function are in dermatology, further research is needed...
  45. ncbi Artificial reduction in transepidermal water loss improves skin barrier function
    I Buraczewska
    ACO HUD NORDIC AB, Research and Development, Box 622, SE 194 26 Upplands Väsby, Sweden
    Br J Dermatol 157:82-6. 2007
    ..Treatment of the skin with moisturizers is also known to influence skin barrier function. Whether or not differences in occlusion between creams contribute to their effects on the skin barrier function is unknown...
  46. doi Commentary on Viewpoint: Sweat electrolyte concentrations obtained from within occlusive coverings are falsely high because sweat itself leaches skin electrolytes
    Lawrence E Armstrong
    J Appl Physiol 105:1378; author reply 1379. 2008
  47. ncbi The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis
    C J Morgan
    Dermatopharmacology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Br J Dermatol 148:434-43. 2003
    ..Dermal drug levels can be measured using cutaneous microdialysis, which is a means of continuously sampling substances from the dermal extracellular fluid...
  48. ncbi The dynamics of transepidermal water loss (TEWL) from hydrated skin
    Francesco Gioia
    Dipartimento di Ingegneria Chimica, Universita di Napoli Federico II, Piazzale Tecchio, 80125 Naples, Italy
    Skin Res Technol 8:178-86. 2002
    ..The aim of this paper is to develop a physical-mathematical model for simulating the dynamics of Epidermal (free-) Water Evaporation (EWE) and of transepidermal water loss of hydrated skin...
  49. ncbi Which bioengineering assay is appropriate for irritant patch testing with sodium lauryl sulfate?
    J Aramaki
    Department of Dermatology, Nippon Medical School, Japan
    Contact Dermatitis 45:286-90. 2001
    ....
  50. ncbi Quantitative description of human skin water dynamics by a disposition-decomposition analysis (DDA) of trans-epidermal water loss and epidermal capacitance
    Luis Monteiro Rodrigues
    Laboratory of Experimental Physiology UCTF, Faculdade de Farmacia da Universidade de Lisboa, Portugal
    Skin Res Technol 9:24-30. 2003
    ..The present paper explores the applicability of this strategy to the in vivo water dynamics assessment...
  51. ncbi Implementation of fatty acid carriers to skin irritation and the epidermal barrier
    N Y Schurer
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Contact Dermatitis 47:199-205. 2002
    ..This review provides a brief overview of the current understanding of mammalian fatty acid (FA) metabolism with respect to epidermal barrier abrogation and repair, including new insights into cellular FA transport and metabolism...
  52. ncbi Comparison of the effects of daily applications between topical corticosteroid and tacrolimus ointments on normal skin: evaluation with noninvasive methods
    Katsuko Kikuchi
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Dermatology 205:378-82. 2002
    ..To evaluate the skin changes of the neck of normal individuals after repeated applications of moderate-strength corticosteroid or tracrolimus ointment for 3 weeks by use of noninvasive biophysical measurements...
  53. ncbi Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis
    K De Paepe
    Department of Toxicology, Vrije Universiteit Brussel, Brussels, Belgium
    Contact Dermatitis 44:337-43. 2001
    ..The cream was then applied 2x/day for 4 consecutive days. Assessment of TEWL clearly showed that recovery of the disrupted skin significantly improved after cream application in comparison to untreated barrier repair...
  54. ncbi Hydration and plasticity following long-term use of a moisturizer: a single-blind study
    Gregor B E Jemec
    Department of Medicine, Roskilde Hospital, Denmark
    Acta Derm Venereol 82:322-4. 2002
    ..No dose-response effect was seen, however. Long-term use of moisturizers increases skin capacitance significantly, but does not change the mechanical properties. In vivo skin hydration is a poor predictor of skin mechanics...
  55. ncbi Variation of skin properties within human forearms demonstrated by non-invasive detection and multi-way analysis
    Peter Aberg
    Division of Medical Engineering, Karolinska Institutet, Huddinge, Sweden
    Skin Res Technol 8:194-201. 2002
    ..It is known that the properties of human skin vary locally. The purpose of this study was to investigate the properties of human volar forearms even further using advanced non-invasive techniques and numerical methods...
  56. ncbi Corticosteroid-induced atrophy and barrier impairment measured by non-invasive methods in human skin
    L Kolbe
    S.K.I.N. Inc, Conshohocken, PA, USA
    Skin Res Technol 7:73-7. 2001
    ..The amount of ceramides, cholesterol, and free fatty acids was reduced. Ultrasound showed thinning of the dermis. CONCLUSION: Non-invasive methods are very useful for quantifying the atrophogenicity of topical corticosteroids...
  57. ncbi Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis
    Paul Gunther Sator
    Division of Special and Environmental Dermatology, Department of Dermatology, University of Vienna Medical School, Austria
    J Am Acad Dermatol 48:352-8. 2003
    ..A disruption of the balance between the two may lead to the clinical manifestation of dryness of skin in patients with atopic dermatitis...
  58. ncbi Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction
    M Kucharekova
    Department of Dermatology, University Hospital Nijmegen, The Netherlands
    Contact Dermatitis 46:331-8. 2002
    ..Different models and clinical trials are needed to establish the usefulness in specific conditions of emollients containing skin-related lipids...
  59. ncbi Coefficient of friction: tribological studies in man - an overview
    Raja K Sivamani
    Center for Tribology, Inc, Campbell, CA, USA
    Skin Res Technol 9:227-34. 2003
    ..This review also outlines what factors are important to consider in future friction studies...
  60. ncbi Portable, inexpensive instruments to quantify stratum corneum hydration and skin erythema: applications to clothing science
    K J Atkins
    School of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Australia
    Dermatol Online J 7:2. 2001
    ..Currently available measuring devices are relatively expensive. Presented here are two inexpensive, hand-held, portable instruments which conveniently measure stratum corneum hydration and skin erythema...
  61. ncbi Free residual chlorine in bathing water reduces the water-holding capacity of the stratum corneum in atopic skin
    Taisuke Seki
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Dermatol 30:196-202. 2003
    ..Second, these results suggest that free residual chlorine exposure in patients with AD may play a role in the development or exacerbation of AD...
  62. doi Improved care and growth outcomes by using hybrid humidified incubators in very preterm infants
    Sung Mi Kim
    Division of Newborn Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 125:e137-45. 2010
    ....
  63. ncbi Role of atrial natriuretic peptide in disturbed water and electrolyte metabolism of guinea pigs infected with Pichinde virus
    Z M Guo
    Department of Clinical and Experimental Physiology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Lab Anim Sci 45:484-92. 1995
    ..Although water intake began to decrease 7 days after virus inoculation, total daily water output (insensible water loss, urine excretion, plus fecal water loss) had little change...
  64. doi Fluid and electrolyte balance in extremely preterm infants <24 weeks of gestation in the first week of life
    Masaki Wada
    Maternal and Perinatal Center, Tokyo Women s Medical University, Tokyo, Japan
    Pediatr Int 50:331-6. 2008
    ..The purpose of the present study was to retrospectively investigate abnormalities in fluid/electrolyte balance during the first postnatal week...
  65. ncbi Operation Everest III: energy and water balance
    K R Westerterp
    Department of Human Biology, Maastricht University, The Netherlands
    Pflugers Arch 439:483-8. 2000
    ..b>Insensible water loss was calculated as total water loss minus urinary and faecal water loss. Energy intake at normoxia was 13...
  66. ncbi Deep vein thrombosis complicating severe hypernatremia, rhabdomyolysis, and acute renal failure in a patient with untreated seizure disorder
    Sanjay Vikrant
    Department of Nephrology, Indira Gandhi Medical College, Shimla, Himachal Pradesh 171001, India
    Clin Exp Nephrol 11:88-91. 2007
    ..Excessive insensible water loss in hot and humid weather, associated with an inability to obtain adequate water replacement, led to a ..
  67. ncbi Physiologic responses of grizzly bears to different methods of capture
    Marc R Cattet
    Canadian Cooperative Wildlife Health Centre, Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, S7N 5B4, Canada
    J Wildl Dis 39:649-54. 2003
    ..higher in PR bears and attributed to reduced body water volume through water deprivation and increased insensible water loss. Overall, different methods of capture resulted in different patterns of physiologic disturbance...
  68. ncbi Evaluation of cutaneous insensible water loss during hyperbaric exposure in humans
    H Yamaguchi
    Marine Ecosystems and Environment Research Department, Japan Marine Science and Technology Center, Yokosuka
    Aviat Space Environ Med 70:990-5. 1999
    ..We designed the present study to measure cutaneous insensible water loss at various pressures during exposure to a simulated saturation dive.
  69. ncbi Quantification of insensible water loss associated with insufflation of nonhumidified CO2 in patients undergoing laparoscopic surgery
    A R Biegner
    Department of Anesthesia, National Naval Medical Center, Bethesda, Maryland, USA
    J Laparoendosc Adv Surg Tech A 9:325-9. 1999
    ..No study to date has quantitated the potential insensible water loss associated with laparoscopic surgical procedures as a result of intra-abdominal humidification of ..
  70. ncbi [Treatment of neonatal hyperbilirubinemia with BiliBed]
    C Lindgren
    Barneintensiv avdeling Barnesentret Ullevål sykehus, Oslo
    Tidsskr Nor Laegeforen 119:4027-9. 1999
    ..This may reflect differences in insensible water loss during treatment...
  71. pmc Molecular insights into the physiology of the 'thin film' of airway surface liquid
    R C Boucher
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    J Physiol 516:631-8. 1999
    ..e. the 'insensible water loss', consequent to conditioning inspired air...
  72. ncbi Biophysical changes after mechanical injury of the stratum corneum in normal skin
    Chang Hun Huh
    Department of Dermatology, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Contact Dermatitis 46:24-8. 2002
    ..However, there were no changes in either water-holding capacity or skin barrier function, and only the SCTT was significantly shortened, after chronic injury of the stratum corneum...
  73. ncbi A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients
    Marie Lodén
    ACO HUD AB, Stockholm, Sweden
    Acta Derm Venereol 82:45-7. 2002
    ..The study showed equal effects on skin dryness as judged by the patients and the dermatologist. In conclusion, a glycerin containing cream appears to be a suitable alternative to urea/sodium chloride in the treatment of atopic dry skin...
  74. ncbi Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice
    Yusuke Honma
    Department of Pharmacology Laboratory, Medical Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama, Japan
    Exp Dermatol 15:501-8. 2006
    ..Mechanical scratching-induced cutaneous barrier disruption may be a useful method for evaluating means of recovery from skin damage...
  75. ncbi Respiratory water loss in free-flying pigeons
    G Michaeli
    Jacob Blaustein Institute for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion, 84990 Israel
    J Exp Biol 204:3803-14. 2001
    ..Because of the tight restrictions imposed by gas exchange in flight, the amount of water potentially lost through respiration is limited...
  76. ncbi Discontinuous carbon dioxide release in the German cockroach, Blattella germanica (Dictyoptera: Blattellidae), and its effect on respiratory transpiration
    Beatrice N Dingha
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849 5413, USA
    J Insect Physiol 51:825-36. 2005
    ..In both strains, cuticular transpiration accounted for approximately 95% of total water loss. The significantly longer duration of the interburst phase of the susceptible strain was not important in reducing water loss...
  77. ncbi Psychrometric limits and critical evaporative coefficients for unacclimated men and women
    W Larry Kenney
    Noll Physiological Research Center and the Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802 6900, USA
    J Appl Physiol (1985) 92:2256-63. 2002
    ..m(-2). Torr(-1) at 36 degrees C) and women (17.7 W. m(-2). Torr(-1) at 36 degrees C and 15.5 W. m(-2). Torr(-1) at 38 degrees C) and may be used to model heat balance responses for unacclimated men and women working in hot environments...
  78. doi Repeatability and individual correlates of basal metabolic rate and total evaporative water loss in birds: a case study in European stonechats
    Maaike A Versteegh
    Animal Ecology Group, Centre for Ecological and Evolutionary Studies, University of Groningen, P O Box 14, 9750 AA, Haren, The Netherlands
    Comp Biochem Physiol A Mol Integr Physiol 150:452-7. 2008
    ..We discuss our results in the context of a review of currently available estimates of repeatability of BMR and TEWL for birds...
  79. ncbi [Measurement of water vapour pressure in the airways of mechanically ventilated patient using different types of humidifiers]
    J Rathgeber
    Albertinen Krankenhaus Hamburg, Abteilung Anästhesiologie und Operative Intensivmedizin
    Anasthesiol Intensivmed Notfallmed Schmerzther 36:560-5. 2001
    ....
  80. ncbi Effect of regular sauna on epidermal barrier function and stratum corneum water-holding capacity in vivo in humans: a controlled study
    D Kowatzki
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Dermatology 217:173-80. 2008
    ..The present data suggest a protective effect of regular sauna on skin physiology, especially surface pH and stratum corneum water-holding capacity...
  81. ncbi Ceramide analogue 14S24 selectively recovers perturbed human skin barrier
    K Vavrova
    Centre for New Antivirals and Antineoplastics, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Heyrovskeho 1203, 50005 Hradec Kralove, Czech Republic
    Br J Dermatol 157:704-12. 2007
    ..Topical ceramide application is an effective therapeutic approach in skin disorders with disturbed barrier function, including atopic dermatitis and psoriasis...
  82. ncbi In vitro human skin model to evaluate water permeability and determine wound dressings' occlusivity
    Xi Zhai
    Department of Dermatology, University of California, School of Medicine, San Francisco, California 94143 0989, USA
    Cutan Ocul Toxicol 26:107-11. 2007
    ..We found no significant decrease in TEWL in the semi-occlusive membrane and even in the film former. This in vitro model provides a fast and economical method of screening the effect of occlusivity in wound dressings...
  83. ncbi Instrumental measurement of the Mantoux test: differential effects of tuberculin and sodium lauryl sulphate on impedance response patterns in human skin
    M Nyrén
    Department of Medicine, Section of Dermatology and Venereology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Dermatology 201:212-7. 2000
    ....
  84. ncbi [Assessment of hydration on the stratum corneum and the influencing factors in neonates]
    Youngmee Ahn
    Department of Nursing, College of Medicine Inha University, 253 YoungHyun Dong, Nam ku Incheon 402 751, Korea
    Taehan Kanho Hakhoe Chi 37:781-9. 2007
    ..The study was conducted to investigate the skin hydration level in various body sites and identify the influencing factors in neonates...
  85. ncbi Skin hydration: a review on its molecular mechanisms
    Sylvie Verdier-Sévrain
    Bio Hybrid, LLC, West Palm Beach, FL, USA
    J Cosmet Dermatol 6:75-82. 2007
    ....
  86. ncbi The effect of liposomes on skin barrier structure
    L Coderch
    CID CSIC, Universidad de Barcelona, Barcelona, Spain
    Skin Pharmacol Appl Skin Physiol 12:235-46. 1999
    ..A lipid order increase is observed by infrared spectroscopy, when these types of liposomes are topically applied, resulting in a strong barrier effect. These results could be useful in designing specific liposomal topical applications...
  87. doi Ceramides and barrier function in healthy skin
    Jakob Mutanu Jungersted
    Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
    Acta Derm Venereol 90:350-3. 2010
    ..Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02)...
  88. ncbi Irritancy ranking of anionic detergents using one-time occlusive, repeated occlusive and repeated open tests
    R A Tupker
    Department of Dermatology, University Hospital, Groningen, The Netherlands
    Contact Dermatitis 40:316-22. 1999
    ..The repeated occlusive test or the one-time patch test may be better to simulate situations in which the skin is occluded after irritation by detergents...
  89. ncbi Murine auricular transepidermal water loss -- a novel approach for evaluating irritant skin reaction in mice
    H Loffler
    Department of Dermatology, Philipp University, Marburg, Germany
    Clin Exp Dermatol 26:196-200. 2001
    ..However, in experimental irritant contact dermatitis, the epidermal barrier disruption, that represents a predominant effect of irritants, cannot be assayed by this..
  90. ncbi Incontinence-associated dermatitis: a consensus
    Mikel Gray
    Department of Urology, University of Virginia, Charlottesville 22908, and Mercy Medical Center North Iowa, Women s Health Center Continence Clinic, Forest Park Building, Mason City, Iowa, USA
    J Wound Ostomy Continence Nurs 34:45-54; quiz 55-6. 2007
    ....
  91. ncbi Beneficial effects of softened fabrics on atopic skin
    J F Hermanns
    Belgian SSTC Research Center 5596, , Belgium
    Dermatology 202:167-70. 2001
    ..In the case of pre-irritated skin, the recovery of the skin was significantly faster when rubbed with softened than with unsoftened fabrics. In conclusion, softened fabrics help mitigate the skin condition in atopic patients...
  92. ncbi Incontinence induces stratum corneum vulnerability and impairs the skin barrier function in the perianal region
    Gojiro Nakagami
    Department of Gerontological Nursing Wound Care Management, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Dermatology 213:293-9. 2006
    ..Incontinence leads to a reduced skin barrier function, while also increasing the risk of skin breakdown...
  93. doi Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity
    Jayanta Gupta
    Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 121:725-730.e2. 2008
    ..Previous investigations of TEWL as a biomarker of skin barrier function have been limited by small sample size, and studies including African American subjects are lacking...
  94. ncbi Anti-irritants I: Dose-response in acute irritation
    Flemming Andersen
    Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Denmark
    Contact Dermatitis 55:148-54. 2006
    ..Only glycerol showed dose-response and effects potentially better than no treatment. There was no significant effect and no difference between the three other AIs...
  95. ncbi Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions
    J W Fluhr
    Department of Dermatology, Klinikum Karlsruhe, Germany
    Dermatology 199:57-60. 1999
    ..To prevent this side effect, natural precursors of RA have been proposed. The aim of the present study was to compare the local tolerance profiles of retinol (ROL), retinaldehyde (RAL) and RA...
  96. ncbi Skin targeted DNA vaccine delivery using electroporation in rabbits II. Safety
    Babu M Medi
    Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, 58105, USA
    Int J Pharm 308:61-8. 2006
    ..The results suggest that the electroporation does not induce any irreversible changes in the skin and can be a useful technique for skin targeted DNA vaccine delivery...
  97. ncbi Lipids of the stratum corneum vary with cutaneous water loss among larks along a temperature-moisture gradient
    Michael Haugen
    Department of Evolution, Ecology, and Organismal Biology, Ohio State University, 312 West 12th Avenue, Columbus, OH 43210, USA
    Physiol Biochem Zool 76:907-17. 2003
    ....
  98. ncbi Basal electrical impedance in relation to sodium lauryl sulphate-induced skin reactions--a comparison of patients with eczema and healthy controls
    Natalia Kuzmina
    Department of Medicine, Section of Dermatology and Venereology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Skin Res Technol 9:357-62. 2003
    ..The present study aimed to examine the effects of basic physiological features, such as baseline electrical impedance (IMP) and transepidermal water loss (TEWL), on reactivity to sodium lauryl sulphate (SLS)...
  99. ncbi Transepidermal water loss and skin capacitance alterations among workers in an ultra-low humidity environment
    Tzu Chieh Chou
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan
    Arch Dermatol Res 296:489-95. 2005
    ..The maximum alterations in TEWL and skin capacitance occurred during 0.5-1.0 months and 2 weeks, respectively. TEWL recovered partially and more slowly than skin capacitance which recovered earlier and almost completely...
  100. ncbi Non-invasive bioengineering methods in an intervention study in 1020 male metal workers: results and implications for occupational dermatology
    Birgitta Kütting
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Contact Dermatitis 62:272-8. 2010
    ..Measurements of transepidermal water loss (TEWL) as an indicator of skin barrier function and colorimetry for quantifying erythema have been recommended for monitoring persons at risk of occupational hand dermatitis...
  101. ncbi Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin
    Ehrhardt Proksch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Int J Dermatol 44:151-7. 2005
    ..Magnesium salts are known to bind water, influence epidermal proliferation and differentiation, and enhance permeability barrier repair...

Research Grants67

  1. PHYSIOLOGY OF WATER BALANCE--RESEARCH AND EDUCATION PROJECT
    Gary Robertson; Fiscal Year: 1999
    ..uncertainties pertain to the published normal values for urinary solute excretion, fluid intake and insensible water loss which must also vary markedly from person to person depending on genetic and environmental factors...
  2. AGE AND CONTROL OF HUMAN SKIN BLOOD-FLOW
    W Kenney; Fiscal Year: 2004
    ..Therefore, the proposed studies under Specific Aim 4 will include differences in muscle mass within age groups. ..
  3. Keratinocyte Migration and Wound Healing
    Jonathan Jones; Fiscal Year: 2009
    ..The results from our three aims will provide mechanistic insight into how alpha6beta4 integrin heterodimers and their associated proteins contribute to tissue remodeling during wound healing and certain pathological conditions. ..
  4. Age and Control of Human Skin Flow
    W Kenney; Fiscal Year: 2009
    ..Furthermore, results from these studies may provide an oral intervention strategy to functionally improve impaired cutaneous vasoreactivity in the aged during thermal stress. ..
  5. Preterm Infants: Light Effects on Health and Development
    Debra Brandon; Fiscal Year: 2004
    ..abstract_text> ..
  6. Function of a Novel Matrix Junction in Endothelial Cells
    Jonathan Jones; Fiscal Year: 2003
    ..In aim 3, we will analyze the function(s) of components of the VMA in angiogenesis in vivo. These studies will provide new insight into the role of integrin/matrix interactions in angiogenesis. ..
  7. AGING & HEMODYNAMICS OF HYPERTHERMIA IN HRT & HYDRATION IN POSTMENOPAUSE
    W Kenney; Fiscal Year: 2002
    ..It is hypothesized that: 1) hydration will increase cardiac output; and 2) hydration with a commercially available sports drink will be better than hydration with water. ..
  8. AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW
    W Kenney; Fiscal Year: 2002
    ..Data from this last proposed investigation operationalizes the SkBF decrement to allow policy-making by health organizations and for modeling biophysical and physiological responses of the elderly to extreme environments. ..
  9. PULMONARY EPITHELIA IN HEALTH AND DISEASE
    Richard Boucher; Fiscal Year: 2008
    ..g., COPD, CF, and asthma, and lead to novel therapies to hydrate airway surfaces to clear the mucus plugs/plaques that produce airways obstruction and infection in these major pulmonary diseases. ..
  10. Breast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ....
  11. Fatigue, depression, and inflammation in cancer survivors: A prospective study
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ..abstract_text> ..
  12. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2007
    ..The long term objective of this project is to understand how these two layers are maintained and work together to protect the lung and thus help design better therapies. (End of Abstract) ..
  13. Keratinocyte Migration and Wound Healing
    Jonathan Jones; Fiscal Year: 2007
    ..The results from our three aims will provide mechanistic insight into how alpha6beta4 integrin heterodimers and their associated proteins contribute to tissue remodeling during wound healing and certain pathological conditions. ..
  14. Asian Teens, substance dependence and conduct disorder
    Joseph Sakai; Fiscal Year: 2007
    ..abstract_text> ..
  15. Breast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress
    Janice Kiecolt Glaser; Fiscal Year: 2008
    ....
  16. Keratinocyte Migration and Wound Healing
    Jonathan Jones; Fiscal Year: 2008
    ..The results from our three aims will provide mechanistic insight into how alpha6beta4 integrin heterodimers and their associated proteins contribute to tissue remodeling during wound healing and certain pathological conditions. ..
  17. Asian Teens, substance dependence and conduct disorder
    Joseph Sakai; Fiscal Year: 2008
    ..abstract_text> ..
  18. Keratinocyte Migration and Wound Healing
    Jonathan Jones; Fiscal Year: 2006
    ..The results from our three aims will provide mechanistic insight into how alpha6beta4 integrin heterodimers and their associated proteins contribute to tissue remodeling during wound healing and certain pathological conditions. ..
  19. Preterm Infants: Light Effects on Health and Development
    Debra Brandon; Fiscal Year: 2006
    ..abstract_text> ..
  20. Function of a Novel Matrix Junction in Endothelial Cells
    Jonathan Jones; Fiscal Year: 2002
    ..In aim 3, we will analyze the function(s) of components of the VMA in angiogenesis in vivo. These studies will provide new insight into the role of integrin/matrix interactions in angiogenesis. ..
  21. AGING & HEMODYNAMICS OF HYPERTHERMIA IN HRT & HYDRATION IN POSTMENOPAUSE
    W Kenney; Fiscal Year: 2001
    ..It is hypothesized that: 1) hydration will increase cardiac output; and 2) hydration with a commercially available sports drink will be better than hydration with water. ..
  22. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2010
    ..Furthermore, results from these studies may provide an oral intervention strategy to functionally improve impaired cutaneous vasoreactivity in the aged during thermal stress. ..
  23. ENDURANCE TRAINING, HEAT STRESS AND SKIN BLOOD FLOW
    W Kenney; Fiscal Year: 1999
    ..Most of the participants have completed both pre- and post-testing. In the future, we may invite some participants back to study the effects of de-training on skin blood flow. ..
  24. ACETAMINOPHEN VS IBUPROFEN ON RENAL FUNCTION DURING EXERCISE
    W Kenney; Fiscal Year: 1999
    ..abstract_text> ..
  25. ACUTE AND CHRONIC EFFECTS OF ESTROGEN REPLACEMENT THERAPY
    W Kenney; Fiscal Year: 1999
    ..Four more experimental trials are necessary for completion of Phase III. We expect to complete this phase by April, 1998. ..
  26. AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW
    W Kenney; Fiscal Year: 2000
    ..Data from this last proposed investigation operationalizes the SkBF decrement to allow policy-making by health organizations and for modeling biophysical and physiological responses of the elderly to extreme environments. ..
  27. AGING & HEMODYNAMICS OF HYPERTHERMIA IN HRT & HYDRATION IN POSTMENOPAUSE
    W Kenney; Fiscal Year: 1999
    ..To examine the effect of age on these responses, seven young and seven older men were head-up tilted in a thermoneutral environment and wearing water-perfused suits. ..
  28. Keratinocyte Migration and Wound Healing
    Jonathan C Jones; Fiscal Year: 2010
    ..The results from our three aims will provide mechanistic insight into how alpha6beta4 integrin heterodimers and their associated proteins contribute to tissue remodeling during wound healing and certain pathological conditions. ..
  29. Aging, Stress, Fatty Acids and Inflammation
    Janice K Kiecolt Glaser; Fiscal Year: 2010
    ....
  30. Hypercholesterolemia and Human Skin Blood Flow
    W Larry Kenney; Fiscal Year: 2010
    ..Specific Aim 4 examines the mechanisms investigated in Aims 1-3 before and after a statin therapy intervention with atrovastatin. ..
  31. AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW
    W Kenney; Fiscal Year: 2001
    ..Data from this last proposed investigation operationalizes the SkBF decrement to allow policy-making by health organizations and for modeling biophysical and physiological responses of the elderly to extreme environments. ..
  32. Breast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ....
  33. Fatigue, depression, and inflammation in cancer survivors: A prospective study
    Janice K Kiecolt Glaser; Fiscal Year: 2010
    ..abstract_text> ..
  34. Breast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress
    Janice K Kiecolt Glaser; Fiscal Year: 2010
    ....
  35. The Role of Anaerobic Bacterial Infection in Cystic Fibrosis
    Richard C Boucher; Fiscal Year: 2010
    ..g., chronic bronchitis. Such observations might change the way physicians approach antibiotic therapy of patients with airways disease. ..
  36. Hypercholesterolemia and Human Skin Blood Flow
    W Kenney; Fiscal Year: 2008
    ..Specific Aim 4 examines the mechanisms investigated in Aims 1-3 before and after a statin therapy intervention with atrovastatin. ..
  37. Substrate stiffness regulates alveolar epithelial cell behavior
    JONATHAN C contact JONES; Fiscal Year: 2010
    ..We propose to assay how the stiffness of the lung regulates the function of its cellular components. Our results will provide novel insight into the mechanisms of disease progression and has implications for future therapies. ..
  38. Hypercholesterolemia and Human Skin Blood Flow
    W Kenney; Fiscal Year: 2009
    ..Specific Aim 4 examines the mechanisms investigated in Aims 1-3 before and after a statin therapy intervention with atrovastatin. ..
  39. PULMONARY, CRITICAL CARE, AND MOLECULAR TRAINING
    Richard Boucher; Fiscal Year: 2008
    ..End of Abstract) ..
  40. AGE & SKIN BLOOD FLOW
    W Kenney; Fiscal Year: 2000
    ..We plan to compare older and younger men and women to examine the mechanism by which aging attenuates reflex active cutaneous vasodillation. ..
  41. AGE & SKIN BLOOD FLOW
    W Kenney; Fiscal Year: 2001
    ..We plan to compare older and younger men and women to examine the mechanism by which aging attenuates reflex active cutaneous vasodillation. ..
  42. AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW
    W Kenney; Fiscal Year: 2003
    ..Data from this last proposed investigation operationalizes the SkBF decrement to allow policy-making by health organizations and for modeling biophysical and physiological responses of the elderly to extreme environments. ..
  43. Function of a Novel Matrix Junction in Endothelial Cells
    Jonathan Jones; Fiscal Year: 2004
    ..In aim 3, we will analyze the function(s) of components of the VMA in angiogenesis in vivo. These studies will provide new insight into the role of integrin/matrix interactions in angiogenesis. ..
  44. AGE AND CONTROL OF HUMAN SKIN BLOOD-FLOW
    W Kenney; Fiscal Year: 2003
    ..Therefore, the proposed studies under Specific Aim 4 will include differences in muscle mass within age groups. ..
  45. PULMONARY, CRITICAL CARE, AND MOLECULAR TRAINING
    Richard Boucher; Fiscal Year: 2007
    ..End of Abstract) ..
  46. Preterm Infants: Light Effects on Health and Development
    Debra Brandon; Fiscal Year: 2005
    ..abstract_text> ..
  47. AGE AND CONTROL OF HUMAN SKIN BLOOD-FLOW
    W Kenney; Fiscal Year: 2005
    ..Therefore, the proposed studies under Specific Aim 4 will include differences in muscle mass within age groups. ..
  48. AGE AND CONTROL OF HUMAN SKIN BLOOD-FLOW
    W Kenney; Fiscal Year: 2007
    ..Therefore, the proposed studies under Specific Aim 4 will include differences in muscle mass within age groups. ..
  49. PULMONARY EPITHELIA IN HEALTH AND DISEASE
    Richard Boucher; Fiscal Year: 2007
    ..g., COPD, CF, and asthma, and lead to novel therapies to hydrate airway surfaces to clear the mucus plugs/plaques that produce airways obstruction and infection in these major pulmonary diseases. ..
  50. Preterm Infants: Light Effects on Health and Development
    Debra Brandon; Fiscal Year: 2007
    ..abstract_text> ..
  51. Aging, Stress, Fatty Acids and Inflammation
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ....
  52. Changes in the Skin Induced by Alcohol Consumption
    Rhonda Brand; Fiscal Year: 2005
    ..This work has important implications for the health and treatment for the millions of people who consume even moderate amounts of alcohol and who may be knowingly or unknowingly exposed to potentially toxic chemicals. ..
  53. Preterm Infants: Light Effects on Health and Development
    Debra Brandon; Fiscal Year: 2003
    ..abstract_text> ..
  54. Aging, Stress, Fatty Acids and Inflammation
    Janice Kiecolt Glaser; Fiscal Year: 2008
    ....