- Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
Benjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 176:85-97. 2010
..These data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease...
- Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
Courtney M Karner
Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Nat Genet 41:793-9. 2009
..Although previous studies showed that polarized cell divisions maintain the diameter of postnatal kidney tubules, we find that cell divisions are randomly oriented during embryonic development...
- Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
Jaklien C Leemans
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Clin Invest 115:2894-903. 2005
..These data imply that TLR2 blockade could provide a basis for therapeutic strategies to treat or prevent renal ischemic injury...
- Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Am Soc Nephrol 17:17-25. 2006
..This has given hope for the development of novel therapeutic approaches against this final common pathway...
- Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension
Soeren S Lienkamp
Department of Medicine, Renal Division, University of Freiburg Medical Center, Freiburg, Germany
Nat Genet 44:1382-7. 2012
..These data resolve long-standing questions concerning the role of PCP signaling in the developing kidney and, moreover, establish rosette-based intercalation as a deeply conserved cellular engine for epithelial morphogenesis...
- Stromal cells protect against acute tubular injury via an endocrine effect
Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
J Am Soc Nephrol 18:2486-96. 2007
..Identification of the stromal cell-derived protective factors may provide new therapeutic options to explore in humans with acute kidney injury...
- Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies
Maria P Rastaldi
Renal Research Association, Renal Immunopathology Centre, San Carlo Borromeo Hospital, Via Pio II, 3, 20153 Milan, Italy
Kidney Int 62:137-46. 2002
..According to this theory, they should proceed through several activating steps, such as proliferation and phenotype changes, to eventually synthesize extracellular matrix (ECM)...
- Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 115:610-21. 2005
..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
- Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis
Laboratory of Clinical and Experimental Immunology, Nephrology Division, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
PLoS ONE 5:e14298. 2010
..Heme-oxygenase-1 (HO-1) is a cytoprotective molecule that has been shown to be beneficial in various models of renal injury. However, the role of HO-1 in reversing an established renal scar has not yet been addressed...
- Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Pathol 159:1465-75. 2001
- Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
J Clin Invest 118:1657-68. 2008
..confirm internalization of apoptotic bodies within KIM-1-expressing epithelial cells after injury in rat kidney tubules in vivo...
- Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
Kidney Int 68:2714-25. 2005
..Here, we tested the hypothesis that cobalt administration not only attenuates acute ischemic insult, but also ameliorates tubulointerstitial injury secondary to chronic hypoxia...
- The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?
R E Gilbert
University of Melbourne, Department of Medicine, West Heidelberg, Victoria, 3081, Australia
Kidney Int 56:1627-37. 1999
..Continued exploration into tubulointerstitial disease in addition to glomerular injury in diabetes may help provide further insights into the pathogenesis of diabetic nephropathy and additional targets for therapeutic intervention...
- Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro
J M Fan
Department of Nephrology, The First Hospital, Western China University of Medical Sciences, Chengdu
Kidney Int 56:1455-67. 1999
..We recently found evidence of tubular epithelial-myofibroblast transdifferentiation (TEMT) during the development of tubulointerstitial fibrosis in the rat remnant kidney. This study investigated the mechanisms that induce TEMT in vitro...
- Intrinsic epithelial cells repair the kidney after injury
Benjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
Cell Stem Cell 2:284-91. 2008
..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney...
- Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney
Department of Pediatrics and Department of Internal Medicine and Division of Basic Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 5390 9063, USA
J Clin Invest 115:1756-64. 2005
..These results show that intrarenal cells are the main source of renal repair, and a single injection of BMCs does not make a significant contribution to renal functional or structural recovery...
- Mesenchymal stem cell-derived microvesicles protect against acute tubular injury
Department of Internal Medicine, Research Center for Experimental Medicine, University of Torino, Torino, Italy
J Am Soc Nephrol 20:1053-67. 2009
..These results suggest that microvesicles derived from MSCs may activate a proliferative program in surviving tubular cells after injury via a horizontal transfer of mRNA...
- Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
D H Kang
Division of Nephrology, University of Washington, Seattle, WA, USA
J Am Soc Nephrol 12:1448-57. 2001
..58 +/- 3.45%, VEGF versus vehicle, P < 0.01). In conclusion, VEGF treatment reduces fibrosis and stabilizes renal function in the RK model. The use of angiogenic factors may represent a new approach to the treatment of kidney disease...
- Inflammation in acute kidney injury
Gilbert R Kinsey
Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
Nephron Exp Nephrol 109:e102-7. 2008
..This review summarizes these recent advances to further our understanding of the immune mechanisms of acute kidney injury...
- The role of epithelial-to-mesenchymal transition in renal fibrosis
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
J Mol Med (Berl) 82:175-81. 2004
..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...
- A novel simpler histological classification for renal survival in IgA nephropathy: a retrospective study
Department of Emergency and Organ Transplantation, Renal, Dialysis and Transplant Unit, University of Bari, Bari, Italy
Am J Kidney Dis 49:763-75. 2007
..We evaluated factors associated with long-term renal survival by using a novel simplified histological classification...
- Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction
Yen Ta Chen
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
J Transl Med 9:51. 2011
..We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury...
- Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury
Mario Negri Institute for Pharmacological Research, Bergamo, Italy
Stem Cells 28:513-22. 2010
..Altogether these results highlight the potential of human CB-MSCs as future cell therapy for testing in human AKI...
- Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis
Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida 32610, USA
Am J Physiol Renal Physiol 278:F726-36. 2000
..These studies provide a basis for future studies using targeted gene expression of HO-1 as a therapeutic and preventive modality in high-risk settings of acute renal failure...
- An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease
Unidad de Fisiopatología Renal y Cardiovascular, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain
Kidney Int 77:950-5. 2010
..Furthermore, renal fibrosis, a TGF-beta-mediated event, is integrated as a potential, indirect effect contributing to tubule deletion...
- Mediators of inflammation in acute kidney injury
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80262, USA
Mediators Inflamm 2009:137072. 2009
..Thus, inflammation has an important role in the initiation and extension phases of AKI. This review will focus on the mediators of inflammation contributing to the pathogenesis of AKI...
- Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling
Department of Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
J Biol Chem 285:24665-75. 2010
..Collectively, these studies identify PAI-1 as a direct downstream target of Wnt/beta-catenin signaling and demonstrate that PAI-1 induction could play a role in mediating the fibrogenic action of this signaling...
- An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin
Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, 37007 Salamanca, Spain
Toxicol Sci 119:245-56. 2011
..The purpose of this review was to critically integrate all these effects and discuss their relative contribution to tubular cell death...
- Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis
Unidad de Dialisis, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
J Am Soc Nephrol 14:3072-80. 2003
..However, endoplasmic reticulum-specific caspase-12 was not activated. CsA induces changes in several apoptotic pathways. However, the main lethal apoptotic pathway in CsA-exposed tubular epithelial cells involves mitochondrial injury...
- Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction
Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan
Kidney Int 81:865-79. 2012
..Thus, TGF-β1 induces VEGF-C expression, which leads to lymphangiogenesis...
- Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 121:2211-20. 2010
..We studied the capacity of human CD34(+) hematopoietic stem/progenitor cells (HSPCs) to promote kidney repair and regeneration using an established ischemia/reperfusion injury model in mice, with particular focus on the microvasculature...
- The effect of alpha-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicity
So Young Lee
Department of Internal Medicine, Eulji College of Medicine, Seoul, Korea
Transplantation 78:1756-64. 2004
..This study evaluated the mechanism for CsA-induced tubular cell apoptosis, tubulointerstitial fibrosis and its associated proteins, and the therapeutic effects of alpha-melanocyte-stimulating hormone (MSH) on them...
- Pathways to nephron loss starting from glomerular diseases-insights from animal models
Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
Kidney Int 67:404-19. 2005
..The only option for extracapillary injuries with tuft adhesion is repair by formation of a segmental adherent scar (i.e., segmental glomerulosclerosis)...
- Crumbs stabilises epithelial polarity during tissue remodelling
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
J Cell Sci 122:2604-12. 2009
- Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4
Department of Pediatrics, Division of Biology and Biomedical Sciences, Washington University School of Medicine, and Saint Louis Children s Hospital, Missouri 63110, USA
Kidney Int 65:2212-22. 2004
..Matrilysin, a secreted matrix metalloproteinase and target gene of Wnt signaling, functions in epithelial repair and host defense, but no role in renal injury has been described...
- Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia
Charuhas V Thakar
Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
J Clin Invest 115:3451-9. 2005
..We propose that TSP-1 is a novel regulator of ischemic damage in the kidney and may play an important role in the pathophysiology of ischemic kidney failure...
- Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction
Neil G Docherty
Department of Surgery, Conway Institute of Biomolecular and Biomedical Sciences, Univ College Dublin, Belfield, Dublin 4, Republic of Ireland
Am J Physiol Renal Physiol 290:F4-13. 2006
..Several interventions that reduce tubular apoptosis are discussed in terms of their ability to prevent subsequent progression to end-organ damage and fibrosis...
- NADPH oxidases in the kidney
Pritmohinder S Gill
Angiogenesis Section, Lombardi Cancer Center, Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, District of Columbia 20007, USA
Antioxid Redox Signal 8:1597-607. 2006
..Experimental studies of the distribution, signaling, and function of NADPH oxidases in the kidney are described...
- The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila
Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
Development 140:1100-10. 2013
..We demonstrate conservation in the expression of the family of tiptop/teashirt genes in lower insects and establish conservation in the targets of Teashirt transcription factors in mouse embryonic kidney...
- Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney
Division of Nephrology, Department of Medicine, The Ottawa Hospital, Ottawa, Ont, Canada
Nephron Exp Nephrol 96:e77-88. 2004
..We studied the extent of apoptosis in streptozotocin (STZ) induced diabetic nephropathy in the rat and the effects of insulin and type 1 (AT1) or type 2 (AT2) Ang II receptor blockade with losartan or PD123319, respectively...
- Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation
Division of Experimental Diabetes and Aging, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Pathol 176:2163-76. 2010
..The expression of tumor-necrosis factor-alpha in 22-month-old diabetic kidneys may play a role in inflammation, ER stress, and apoptosis. Thus, diabetes may accelerate the underlying kidney aging process present in old mice...
- Active Ca(2+) reabsorption in the connecting tubule
Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
Pflugers Arch 458:99-109. 2009
..In addition, an overview of the recently identified mechanisms governing this active Ca(2+) transport through the DCT2/CNT epithelial cells will be presented...
- Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis
Division of Nephrology and Dialysis and Biochemical Laboratory, San Carlo Borromeo Hospital, Milan, Italy
Nephrol Dial Transplant 17:1890-6. 2002
..The second aim was to assess whether NAG excretion has a predictive value on functional outcome and response to therapy...
- Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells
Center of Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, China
Am J Physiol Renal Physiol 299:F336-46. 2010
..Our findings highlight a need for carefully reevaluating our previous view on the pathological roles of hyperuricemia in the kidney and nephropathy induced by uric acid in clinical practice...
- Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage
Perla D Maldonado
Department of Biology, Universidad Nocional Autonoma de Mexico, Mexico D F, Mexico
Free Radic Biol Med 35:317-24. 2003
..In conclusion, SAC ameliorates the GM-induced ARF by a mechanism related, at least in part, to its ability to decrease oxidative stress and to preserve antioxidant enzymes activity in renal cortex...
- Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation
Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
Diabetes 60:1907-16. 2011
..We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys...
- Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis
Department of Nephrology, Hannover Medical School, Hannover, Germany
Kidney Int 80:1035-44. 2011
..Thus, our study suggests that fibrinogen promotes renal fibrosis by triggering resident fibroblast proliferation...
- Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
Kidney Int 81:662-73. 2012
..Hence, inhibition of GSK3β ameliorates NSAID-induced acute kidney injury by induction of renal cortical COX-2 and direct inhibition of the mitochondrial permeability transition...
- Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 52:497-506. 2012
..Because similar compounds seem to be safe in humans, mitochondrially targeted antioxidants may represent a novel therapeutic approach against cisplatin nephrotoxicity...
- Preconditioning with physiological levels of ethanol protect kidney against ischemia/reperfusion injury by modulating oxidative stress
Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
PLoS ONE 6:e25811. 2011
..The purpose of current study is to demonstrate the effect of antecedent ethanol exposure on IR-induced renal injury by modulation of oxidative stress...
- An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice
Department of Cellular and Molecular Pathology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Nat Med 14:979-84. 2008
..These experiments establish Pax8-rtTA mice as a powerful tool for modeling renal diseases in transgenic mice...
- Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury
Center for Surgical Research, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
Nephrol Dial Transplant 26:1474-83. 2011
..We recently demonstrated that microvesicles (MVs) released from MSCs may account for this paracrine mechanism by a horizontal transfer of messenger RNA and microRNA...
- Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Mail Code 9063, Dallas, TX 75390 9063, USA
J Am Soc Nephrol 14:1188-99. 2003
..This is the first report to show that HSC can differentiate into renal tubular cells after I/R injury. Because of their availability, HSC may be useful for cell replacement therapy of acute renal failure...
- Loss of oriented cell division does not initiate cyst formation
Section of Nephrology, Yale University School of Medicine, P O Box 208029, 333 Cedar Street, New Haven, CT 06520 8029, USA
J Am Soc Nephrol 21:295-302. 2010
..In conclusion, loss of oriented cell division is a feature of Pkhd1 mutation and cyst formation, but it is neither sufficient to produce kidney cysts nor required to initiate cyst formation after mutation in Pkd1 or Pkd2...
- Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo
Intern Med 43:9-17. 2004
..This induces chronic hypoxia in this compartment, rendering a vicious cycle. Development of novel therapeutic approaches against these final common pathways will enable us to target any types of renal disease...
- Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India
Eur J Pharmacol 606:162-71. 2009
..To conclude, DAS enhances antioxidants and suppresses inflammatory cytokines through the activation of Nrf2, thereby protecting the cell against oxidative stress induced by gentamicin...
- Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
Jeremy S Duffield
Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Invest 115:1743-55. 2005
..It is likely that intrinsic tubular cell proliferation accounts for functionally significant replenishment of the tubular epithelium after ischemia...
- Recent advances in the pathophysiology of ischemic acute renal failure
Joseph V Bonventre
Renal Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, and the Harvard MIT, Division of Health Sciences and Technology, Charlestown, Massachusetts, USA
J Am Soc Nephrol 14:2199-210. 2003
- Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function
I A Drummond
Renal Unit, Massachusetts General Hospital, Charlestown MA 02129, USA
Development 125:4655-67. 1998
..These studies reveal the similarity of normal pronephric development to kidney organogenesis in all vertebrates and allow for a genetic dissection of genes needed to establish the earliest renal function...
- Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 19:1741-52. 2008
..These results suggest that paricalcitol inhibits renal inflammatory infiltration and RANTES expression by promoting VDR-mediated sequestration of NF-kappaB signaling...
- A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis
Michelle P Winn
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Science 308:1801-4. 2005
..Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease...
- Differential expression and function of cadherin-6 during renal epithelium development
E A Cho
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0650, USA
Development 125:803-12. 1998
..These data suggest that cadherin-6 function is required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithelium...
- Apoptosis in the kidneys of patients with type II diabetic nephropathy
Nephrology Division, Department of Internal Medicine, Genoa University, Genoa, Italy
Kidney Int 72:1262-72. 2007
..Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients...
- Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ
Balu K Chacko
Department of Pathology, University of Alabama at Birmingham, 35294, USA
Biochem J 432:9-19. 2010
..They also highlight a relatively unexplored aspect of mitochondrial ROS signalling in the control of fibrosis...
- Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
FASEB J 19:1789-97. 2005
..These results suggest rKS56 cells possess character such as self-renewal, multi-plasticity and capability of tissue repair. rKS56 may possibly contribute to the future development of cell therapy for renal regeneration...
- Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
Lab Invest 85:1292-307. 2005
..Collectively, these findings demonstrate a renoprotective role of HIF through angiogenesis and provide a rationale for therapeutic approaches to target HIF for activation...
- Autosomal dominant polycystic kidney disease
Vicente E Torres
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Lancet 369:1287-301. 2007
- Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein
Medizinische Poliklinik University of Munich, Munich, Germany
J Immunol 183:4109-18. 2009
..Thus, loss of function mutations in the SIGIRR gene predispose to acute renal failure because SIGIRR prevents overshooting tissue injury by suppressing the postischemic activation of intrarenal myeloid cells...
- Proteinuria and hyperglycemia induce endoplasmic reticulum stress
Maja T Lindenmeyer
Nephrology Center, Medizinische Poliklinik, University of Munich, Munich, Germany
J Am Soc Nephrol 19:2225-36. 2008
..Although this may protect the cells from ER stress, persistence of hyperglycemia and proteinuria may eventually lead to apoptosis...
- Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
V Y Melnikov
Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Clin Invest 107:1145-52. 2001
..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
- Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury
Renal Diagnostics and Therapeutics Unit, NIDDK, and Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892-1268, USA
Kidney Int 60:2118-28. 2001
..CONCLUSIONS: IL-10 protects against renal ischemic and cisplatin-induced injury. IL-10 may act, in part, by inhibiting the maladaptive activation of genes that cause leukocyte activation and adhesion, and induction of iNOS...
- TGF-beta1 siRNA suppresses the tubulointerstitial fibrosis in the kidney of ureteral obstruction
Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea
Exp Mol Pathol 81:48-54. 2006
..This work would provide a valuable tool to prevent tubulointerstitial fibrosis using RNA interference strategy...
- The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice
Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
Am J Pathol 170:1267-76. 2007
..These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy...
- Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants
Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Physiol Genomics 41:33-41. 2010
..The physiological impacts of defective ANT expression are thus widespread and diverse...
- Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia
J G Hoenderop
Department of Cell Physiology, Institute of Cellular Signaling, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
J Biol Chem 274:8375-8. 1999
..Thus, ECaC has the expected properties for being the gatekeeper of 1,25-dihydroxyvitamin D3-dependent active transepithelial Ca2+ transport...
- Inflammatory cytokines and lipopolysaccharide induce Fas-mediated apoptosis in renal tubular cells
Sang Kyung Jo
Department of Internal Medicine, Korea University Hospital, Anam dong 5Ka, 136 705 Sungbuk ku, Seoul, Korea
Nephron 91:406-15. 2002
- Autophagy protects renal tubular cells against cyclosporine toxicity
INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, Paris, France
Autophagy 4:783-91. 2008
..Taken together, these results demonstrate that CsA, through ER stress induction, activates autophagy as a protection against cell death...
- Renal localization and function of the tight junction protein, claudin-19
Department of Medicine, Division of Nephrology, Univesity of Southern California Keck School of Medicine, 2025 Zonal Ave, RMR 406, Los Angeles, CA 90033, USA
Am J Physiol Renal Physiol 293:F166-77. 2007
..This would be consistent with its physiological role to electrically seal myelinated peripheral neurons. The normal role of claudin-19 in renal tubule function remains to be determined...
- Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury
Dept of Pediatrics, Columbia Univ College of Physicians and Surgeons, 630 West 168th St, New York, NY 10032, USA
Am J Physiol Renal Physiol 302:F9-F19. 2012
..Our study indicates that hematopoietic stem and progenitor cells can be converted to a large number of renal-like cells within a short period for potential treatment of acute kidney injury...
- Differential gene expression following early renal ischemia/reperfusion
Pediatric Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
Kidney Int 63:1714-24. 2003
..The purpose of this study was to identify apoptosis-related genes that are differentially expressed in the early periods following renal ischemia...
- Molecular clock is involved in predictive circadian adjustment of renal function
Annie Mercier Zuber
Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland
Proc Natl Acad Sci U S A 106:16523-8. 2009
..Collectively, this study uncovers a major role of molecular clock in renal function...
- Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney
Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
J Am Soc Nephrol 17:188-98. 2006
..Collectively, these findings suggest that LRTC are an adult kidney tubular cell population that shows phenotypic plasticity, tubulogenic capacity, and integration capability into the developing kidney...
- Primary IgA nephropathy: new insights into pathogenesis
The John Walls Renal Unit, Leicester General Hospital and Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
Semin Nephrol 31:349-60. 2011
..Genetic factors are likely to influence many facets of pathogenesis both in primary and familial IgA nephropathy, however, to date work in this area has failed to identify consistent candidate genes...
- Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity
Laboratorio de Metabolismo Mineral y Oseo, Pathology Department, Fundación Jiménez and Universidad Autónoma de Madrid, Spain
J Am Soc Nephrol 17:1594-603. 2006
..Our findings indicate that this peptide, by interaction with the PTH1 receptor, can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor in the FA-damaged kidney...
- Kidney injury molecule-1 in renal disease
Kidney Centre, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
J Pathol 220:7-16. 2010
..Finally, the potential of KIM-1 as biomarker of renal damage, as a predictor of renal function decline and its perspectives for monitoring therapy response, are discussed...
- Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
Am J Pathol 177:632-43. 2010
..In conclusion, overexpression of TGF-beta1 in renal tubules in vivo induces interstitial proliferation, tubular autophagy, and fibrosis, but not epithelial-to-mesenchymal transition...
- Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours
Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, 08028 Barcelona, Spain
Mech Dev 127:345-57. 2010
..We suggest that the formation of zonula adherens junctions between new cell neighbours establishes their apico-basal positions and stabilises them in the epithelium...
- A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract
Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
J Am Soc Nephrol 13:1824-36. 2002
..Transgenic mice that express GFP in the mesonephros, metanephros, ureteric bud, and sex ducts may be useful for cell lineage studies...
- p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway
Dept of Nephrology, 2nd Xiangya Hospital, Central South Univ, No 139 Renmin Middle Rd, Changsha, Hunan 410011
Am J Physiol Renal Physiol 299:F1014-25. 2010
..These data suggest that p66Shc mediates HG- and ANG II-induced mitochondrial dysfunctions via PKC-β and Pin1-dependent pathways in renal tubular cells...
- Expression of the chemokine receptor CCR1 in human renal allografts
Medizinische Poliklinik Innenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
Nephrol Dial Transplant 22:1720-9. 2007
..CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts...
- Kidney failure in mice lacking the tetraspanin CD151
Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
J Cell Biol 175:33-9. 2006
..Our results support the hypothesis that CD151 plays a key role in strengthening alpha3beta1-mediated adhesion in podocytes...
- Activation of tubular epithelial cells in diabetic nephropathy
Department of Internal Medicine 1, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
Diabetes 51:3532-44. 2002
- What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)?
Charles L Edelstein
Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Cell Cycle 4:1550-4. 2005
..Thus, there is evidence that both epithelial cell apoptosis and proliferation are dysregulated in ADPKD and may represent a general mechanism for cyst growth...
- Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
J Virol 85:9811-23. 2011
..The finding that different renal cell types are susceptible to hantaviral infection and the fact that infection results in the breakdown of cell-to-cell contacts provide useful insights in hantaviral pathogenesis...
- Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 13:2464-77. 2002
..These findings may provide the basis for designing future therapeutic regimens for blocking progressive renal fibrosis in patients...
- Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice
Department of Biochemistry 1, Hamamatsu University School of Medicine, Japan
Am J Pathol 171:473-83. 2007
..These findings suggest that p27 accumulation, which results from SCF-Skp2 ubiquitin ligase deficiency in Skp2(-/-) mice, is involved in the amelioration of renal damage induced by obstructive nephropathy...
- Adult human CD133/1(+) kidney cells isolated from papilla integrate into developing kidney tubules
Heather H Ward
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Biochim Biophys Acta 1812:1344-57. 2011
..culture demonstrated that CD133/1(+) progenitors from the papilla and cortex became integrated into developing kidney tubules. Tubular epithelia did not participate in tubulogenesis...
- Conditional ablation of glycogen synthase kinase 3β in postnatal mouse kidney
Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02903, USA
Lab Invest 91:85-96. 2011
..Extended examinations of these KO under diseased conditions are merited to understand the role of GSK3β in renal pathophysiology...
- Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 20:1907-18. 2009
..These findings suggest that increased ILK activity mediates EMT and the progression of renal fibrosis. Pharmacologic inhibition of ILK signaling may hold therapeutic potential for fibrotic kidney diseases...
- Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Free Radic Biol Med 49:1273-82. 2010
..RW injury of renal tubular cells and suggest that therapeutic inhibition of these pathways may protect the donor kidney...
- Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy
Susan P Bothwell
University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
J Am Soc Nephrol 22:443-8. 2011
..Thus, we created an animal model for OCRL and Dent Disease 2 tubulopathy by humanizing a modifier paralog in mice already carrying the mutant disease gene...