kidney medulla

Summary

Summary: The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.

Top Publications

  1. ncbi Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat
    Anumeet Priyadarshi
    Department of Medicine, Medical College of Ohio, Toledo, Ohio 43699 0008, USA
    Kidney Int 61:542-6. 2002
  2. ncbi Cellular response to hyperosmotic stresses
    Maurice B Burg
    National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Physiol Rev 87:1441-74. 2007
  3. ncbi Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2
    D Kultz
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 273:13645-51. 1998
  4. pmc High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:9491-6. 2004
  5. ncbi Production and actions of superoxide in the renal medulla
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Hypertension 37:547-53. 2001
  6. ncbi Role of renal medullary adenosine in the control of blood flow and sodium excretion
    A P Zou
    Departments of Physiology and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 276:R790-8. 1999
  7. ncbi Renal oxidative stress in medullary thick ascending limbs produced by elevated NaCl and glucose
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 43:341-6. 2004
  8. ncbi Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 68:145-54. 2005
  9. ncbi Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow
    Paul M O'Connor
    Dept of Physiology, Medical College of Wisconsin, 8071 Watertown Plank Road, Milwaukee, WI 53266, USA
    Am J Physiol Renal Physiol 290:F688-94. 2006
  10. ncbi Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells
    L Michea
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 278:F209-18. 2000

Research Grants

Detail Information

Publications217 found, 100 shown here

  1. ncbi Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat
    Anumeet Priyadarshi
    Department of Medicine, Medical College of Ohio, Toledo, Ohio 43699 0008, USA
    Kidney Int 61:542-6. 2002
    ..However, it is not clear why this response is blunted. Oxygen tension is an important regulator of erythropoietin production and release, but the effect of reduced renal mass on renal tissue oxygen tensions is currently unknown...
  2. ncbi Cellular response to hyperosmotic stresses
    Maurice B Burg
    National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Physiol Rev 87:1441-74. 2007
    ....
  3. ncbi Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2
    D Kultz
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 273:13645-51. 1998
    ....
  4. pmc High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:9491-6. 2004
    ..Carbonyl content is high in mouse renal inner medullas where interstitial NaCl and urea concentrations are normally high. There, numerous proteins are carbonylated, and carbonylation occurs in both collecting ducts and thin limbs...
  5. ncbi Production and actions of superoxide in the renal medulla
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Hypertension 37:547-53. 2001
    ..is primarily produced in the renal OM; (2) both NADH oxidase and mitochondrial enzymes are responsible for the O(2)(-.)production in this kidney region; and (3) O(2)(-. )exerts a tonic regulatory action on renal MBF...
  6. ncbi Role of renal medullary adenosine in the control of blood flow and sodium excretion
    A P Zou
    Departments of Physiology and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 276:R790-8. 1999
    ....
  7. ncbi Renal oxidative stress in medullary thick ascending limbs produced by elevated NaCl and glucose
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 43:341-6. 2004
    ..We conclude that elevations of extracellular NaCl, D-glucose, or T3 levels can activate both the Na+/K+-ATPase pump and Na+/H+ exchanger in mTAL, which, in turn, is associated with increased intracellular concentrations of superoxide...
  8. ncbi Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 68:145-54. 2005
    ..Thus our purpose here is to detail the structure of the interstitial and membrane-bound plaque and explore the relationship of plaque apatite to osteopontin, a well-known crystal-associated urine protein...
  9. ncbi Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow
    Paul M O'Connor
    Dept of Physiology, Medical College of Wisconsin, 8071 Watertown Plank Road, Milwaukee, WI 53266, USA
    Am J Physiol Renal Physiol 290:F688-94. 2006
    ..Thus, although cortical and medullary blood flow may be independently regulated, medullary oxygenation may be compromised during moderate to severe cortical ischemia even when medullary blood flow is maintained...
  10. ncbi Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells
    L Michea
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 278:F209-18. 2000
    ..We conclude that elevated NaCl and/or urea reduces the number of proliferating mIMCD3 cells by slowing the transit through the S phase, by cell cycle delay in the G(2)M and G(1), and by inducing apoptotic cell death...
  11. ncbi Chronic hyperosmolarity mediates constitutive expression of molecular chaperones and resistance to injury
    Bento C Santos
    Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston 02115, USA
    Am J Physiol Renal Physiol 284:F564-74. 2003
    ..HT cells demonstrate that in renal medullary cells, hyperosmotic stress activates biological processes that confer cross-tolerance to other stressful conditions...
  12. ncbi Stone formation is proportional to papillary surface coverage by Randall's plaque
    Samuel C Kim
    Methodist Hospital Institute for Kidney Stone Disease, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 173:117-9; discussion 119. 2005
    ..We measured plaque areas in idiopathic CaOx stone formers and nonstone formers (NSF), and identified significant relationships with quantified stone histories...
  13. pmc Cellular mechanisms underlying nitric oxide-induced vasodilation of descending vasa recta
    AURELIE EDWARDS
    Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
    Am J Physiol Renal Physiol 300:F441-56. 2011
    ..We conclude that intrinsic generation of NO by the DVR wall may be sufficient to inhibit vasoconstriction by maintaining suppression of MLC phosphorylation...
  14. ncbi Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells
    W Tian
    Division of Nephrology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Am J Physiol Renal Physiol 281:F983-91. 2001
    Epithelial cells derived from the mammalian kidney medulla are responsive to urea at the levels of signal transduction and gene regulation...
  15. ncbi Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb
    Michiaki Abe
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 291:F350-7. 2006
    ..This may lead to reduction in medullary blood flow and promote hypoxia and tubular necrosis within the renal medulla during in hypertension...
  16. ncbi Hypertension and cyclooxygenase-2 inhibitors: target: the renal medulla
    Chuan Ming Hao
    Hypertension 44:396-7. 2004
  17. ncbi Origin and types of calcium oxalate monohydrate papillary renal calculi
    Felix Grases
    Laboratory of Renal Lithiasis Research, Faculty of Sciences, Universitary Institute of Health Sciences Research, University of Balearic Islands, Palma de Mallorca, Spain
    Urology 76:1339-45. 2010
    ..To assess the mechanism of formation, we sought to correlate the fine structure of papillary renal calculi with specific pathophysiologic conditions and urinary alterations...
  18. ncbi Control of the renal medullary circulation by vasopressin V1 and V2 receptors in the rat
    A W Cowley
    Department Physiology, Medical College of Wisconsin, Milwaukee, USA
    Exp Physiol 85:223S-231S. 2000
    ..These changes are essential to provide a constancy of blood flow to the renal medulla and buffer against the hypertensive actions of this potent vasoconstrictor peptide...
  19. ncbi Intrarenal blood flow: microvascular anatomy and the regulation of medullary perfusion
    T L Pallone
    Division of Nephrology, University of Maryland at Baltimore, USA
    Clin Exp Pharmacol Physiol 25:383-92. 1998
    ..Lack of medullary autoregulation during volume expansion may be part of fundamental processes that regulate salt and water excretion...
  20. ncbi A model of nitric oxide tubulovascular cross talk in a renal outer medullary cross section
    Wensheng Zhang
    Dept of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
    Am J Physiol Renal Physiol 292:F711-22. 2007
    ..However, concomitant increases in epithelial superoxide (O(2)(-)) production would counteract this effect. This model confirms the importance of NO and O(2)(-) interactions in mediating tubulovascular cross talk...
  21. ncbi Pericyte regulation of renal medullary blood flow
    T L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Exp Nephrol 9:165-70. 2001
    ..Known vasoconstrictors of DVR include angiotensin II, endothelins, norepinephrine, acetylcholine, and adenosine. Vasodilators include prostaglandin E2, adenosine, acetylcholine, bradykinin, and nitric oxide...
  22. ncbi Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstriction
    Jeffrey G Dickhout
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circ Res 91:487-93. 2002
    ..We conclude that Ang II increases [Ca2+]i in pericytes of the descending vasa recta as part of its constrictor action and that this vasoconstriction is buffered by the NO from the surrounding tubular elements, such as mTALs...
  23. ncbi Neural control of renal medullary perfusion
    Gabriela A Eppel
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 31:387-96. 2004
    ..Failure of these mechanisms would promote reductions in MBF in response to physiological activation of the renal nerves, which could, in turn, lead to salt and water retention and hypertension...
  24. ncbi Role of nitric oxide in regulation of the renal medulla in normal and hypertensive kidneys
    Thomas L Pallone
    Department of Medicine, Nephrology Division, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Nephrol Hypertens 11:93-8. 2002
    ..The likelihood that some forms of hypertension result directly from pathological alteration of transporters, channels, regulatory elements or enzymes that affect medullary nitric oxide seems high...
  25. ncbi Effects of adenosine on ion transport in rat medullary thick ascending limb
    R E Beach
    Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550
    Am J Physiol 263:F482-7. 1992
    ..These results support the hypothesis that Ado released into the renal medulla during hypoxia may protect the MTAL from ischemic injury by directly inhibiting NaCl absorption and reducing transport-related oxygen consumption...
  26. ncbi An intact kidney slice model to investigate vasa recta properties and function in situ
    C Crawford
    Medway School of Pharmacy, The Universities of Kent and Greenwich at Medway, Chatham, UK
    Nephron Physiol 120:p17-31. 2012
    ..We describe a live kidney slice model in which pericyte-mediated vasa recta constriction/dilation can be visualized in situ...
  27. ncbi A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. Formulation and base-case results
    Anita T Layton
    Department of Mathematics, Duke University, Durham, NC 27708 0320, USA
    Am J Physiol Renal Physiol 289:F1346-66. 2005
    ..Am J Physiol Renal Physiol 289: F1367-F1381, 2005), the impact of model assumptions, medullary anatomy, and tubular segmentation on the UCM was investigated by means of extensive parameter studies...
  28. ncbi Responses to acute changes in arterial pressure on renal medullary nitric oxide activity in dogs
    D S Majid
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hypertension 34:832-6. 1999
    ..These data support the hypothesis that acute changes in RAP elicit changes in intrarenal NO production, which may participate in the mediation of pressure natriuresis...
  29. ncbi The regulation of blood perfusion in the renal cortex and medulla by reactive oxygen species and nitric oxide in the anaesthetised rat
    A F Ahmeda
    Department of Physiology, University College Cork, Ireland
    Acta Physiol (Oxf) 204:443-50. 2012
    ..This investigation examined the hypothesis that reactive oxygen species has both direct and indirect actions, via scavenging NO, to determine the degree of blood perfusion through the renal medulla...
  30. ncbi Autoregulation of renal medullary blood flow in rabbits
    Gabriela A Eppel
    Department of Physiology, Monash University, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 284:R233-44. 2003
    ..These data do not, however, exclude the possibility that MBF is increased with increasing RAP in this model, because vasa recta recruitment may occur...
  31. ncbi Adenosine signaling in outer medullary descending vasa recta
    E P Silldorff
    Biology Department, Towson University, Towson, Baltimore, Maryland 21201, USA
    Am J Physiol Regul Integr Comp Physiol 280:R854-61. 2001
    ..We conclude that OMDVR vasodilation by adenosine involves cAMP and COX but not NO. COX blockade does not fully inhibit selective A(2) receptor-mediated OMDVR dilation...
  32. ncbi Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla
    Valery Grinevich
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Kidney Int 65:54-62. 2004
    ..To test this hypothesis, we examined the effect of lipopolysaccharide (LPS) injection on the expression of V2 receptors and aquaporin-2 in the kidney...
  33. ncbi p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication
    N Dmitrieva
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10, Rm 6N260, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 281:F522-30. 2001
    ....
  34. pmc Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, and Gene Response Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:184-9. 2002
    Cells in the kidney medulla are subject to variable and often extreme osmotic stress during concentration of the urine. Previous studies showed that renal inner medullary epithelial (IME) cells respond to hypertonicity by G(2) arrest...
  35. ncbi Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla
    F Park
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol 273:R1742-8. 1997
    ....
  36. ncbi Nephrolithiasis and nephrocalcinosis in rats with small bowel resection
    R Corey O'Connor
    Department of Urology, University of Chicago, Chicago, IL, USA
    Urol Res 33:105-15. 2005
    ..The model allows further studies of the mechanisms of renal crystal formation, and possible therapeutic interventions...
  37. ncbi Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation
    N Dmitrieva
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603 and the Whitney Laboratory, University of Florida, St Augustine, Florida 32086 8623, USA
    J Biol Chem 275:18243-7. 2000
    ..We conclude that induction of active p53 in mIMCD3 cells by hypertonic stress contributes to cell survival...
  38. ncbi Aquaporin-2 downregulation in kidney medulla of aging rats is posttranscriptional and is abolished by water deprivation
    S Combet
    CEA, Institut de Biologie et Technologies de Saclay and CNRS URA 2096, Orsay, France
    Am J Physiol Renal Physiol 294:F1408-14. 2008
    ..In the IMCD, no change in AQP2 mRNA was detected with aging but AQP2 protein expression was markedly lower in 30-mo-old animals. In conclusion, there is a posttranscriptional downregulation of AQP2 with aging, which is abolished by WD...
  39. ncbi Physiology of the renal medullary microcirculation
    Thomas L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Am J Physiol Renal Physiol 284:F253-66. 2003
    ..To optimize urea trapping, DVR endothelia express the UT-B facilitated urea transporter. These and other features show that vasa recta have physiological mechanisms specific to their role in the renal medulla...
  40. pmc Effect of peristaltic contractions of the renal pelvic wall on solute concentrations of the renal inner medulla in the hamster
    Mary Ella C Pruitt
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 290:F892-6. 2006
    ..This procedure also significantly decreased inner medullary osmolality. We conclude that elimination of the contractions of the renal pelvic wall in the hamster significantly impairs inner medullary concentrating ability...
  41. ncbi Increased renal medullary endothelin-1 synthesis in prehypertensive DOCA- and salt-treated rats
    T J Hsieh
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80317, Taiwan
    Am J Physiol Renal Physiol 279:F112-21. 2000
    ..Our results suggest that renal medullary synthesized ET-1 may be a natriuretic factor and may participate in the intrarenal regulation of water and salt homeostasis in prehypertensive DOCA-and salt-treated rats...
  42. ncbi Effects of endocrine disruptors on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes
    Yohko Fujimoto
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Prostaglandins Leukot Essent Fatty Acids 73:447-52. 2005
    ..of PG and AA-CoA from 5 microM AA (close to the physiological concentration of the substrate) in rabbit kidney medulla microsomes. The kidney medulla microsomes were incubated with 5 microM [(14)C]-AA in 0...
  43. pmc Collecting duct-derived endothelin regulates arterial pressure and Na excretion via nitric oxide
    Markus P Schneider
    Vascular Biology Center, Medical College of Georgia, Augusta, USA
    Hypertension 51:1605-10. 2008
    ....
  44. ncbi Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer
    Mark A Knepper
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 284:F433-46. 2003
    ....
  45. ncbi Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medulla
    M A Burnatowska-Hledin
    Department of Biology, Peale Science Center, Hope College, Holland 49422 9000, USA
    Am J Physiol 268:F1198-210. 1995
    ..The deduced amino acid sequence is not homologous with any nucleic acid or amino acid sequences reported to date, including those of the V1 and V2 AVP receptors. The VACM-1 protein may represent a novel AVP receptor...
  46. pmc Renal medullary ETB receptors produce diuresis and natriuresis via NOS1
    Daisuke Nakano
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Renal Physiol 294:F1205-11. 2008
    ..These results demonstrate that renal medullary ET(B) receptor activation induces diuretic and natriuretic responses through a NOS1, cGMP, and PKG pathway...
  47. ncbi Living with DNA breaks is an everyday reality for cells adapted to high NaCl
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Cell Cycle 3:561-3. 2004
    ....
  48. ncbi Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla
    S Uchida
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    J Biol Chem 268:3821-4. 1993
    ..The site of expression and the regulation by dehydration suggest that CIC-K1 function may be important in urinary concentrating mechanisms...
  49. pmc Gene expression in the normal adult human kidney assessed by complementary DNA microarray
    John P T Higgins
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 15:649-56. 2004
    ..The distinctive patterns of gene expression in discrete portions of the kidney may serve as a resource for further understanding of renal physiology and the molecular and cellular organization of the nephron...
  50. pmc Upregulation and intrarenal redistribution of heat shock proteins 90alpha and 90beta by low-sodium diet in the rat
    Victoria Ramirez
    Molecular Physiology Unit, Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, 14000 Mexico
    Cell Stress Chaperones 9:198-206. 2004
    ..Hsp90alpha and Hsp90beta upregulation induced by a low-sodium diet together with redistribution in thick ascending limb cells suggests that Hsp90 plays a role in the modulation of sodium reabsorption under these circumstances...
  51. pmc c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892 1603
    FASEB J 24:4325-35. 2010
    ..Thus, c-Abl is the kinase responsible for high NaCl-induced phosphorylation of TonEBP/OREBP-Y143, which contributes to its increased activity...
  52. ncbi Enzymes involved in osmolyte synthesis: how does oxidative stress affect osmoregulation in renal cells?
    Jesús A Rosas-Rodríguez
    Centro de Investigación en Alimentación y Desarrollo A C, Apartado Postal 1735, Hermosillo, Sonora, Mexico
    Life Sci 87:515-20. 2010
    b>Kidney medulla cells are exposed to a wide range of changes in the ionic and osmotic composition of their environment as a consequence of the urine concentrating mechanism...
  53. pmc Cloning, genomic organization, and osmotic response of the aldose reductase gene
    J D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:10742-6. 1994
    ..Identification and characterization of OREs within this fragment and their associated trans-acting factors should reveal the molecular mechanisms of gene regulation in osmotic stress...
  54. ncbi The osmotic gradient in kidney medulla: a retold story
    S Kurbel
    Department of Physiology, Osijek Medical Faculty, 31000 Osijek, Croatia
    Adv Physiol Educ 26:278-81. 2002
    This article is an attempt to simplify lecturing about the osmotic gradient in the kidney medulla. In the model presented, the kidneys are described as a limited space with a positive interstitial hydrostatic pressure...
  55. ncbi Adaptation of kidney medulla to hypertonicity: role of the transcription factor TonEBP
    Seung Kyoon Woo
    Division of Nephrology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Int Rev Cytol 215:189-202. 2002
    The osmolality of the mammalian kidney medulla is very high...
  56. ncbi Greater tolerance of renal medullary cells for a slow increase in osmolality is associated with enhanced expression of HSP70 and other osmoprotective genes
    Qi Cai
    National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10, Rm 6N319, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 286:F58-67. 2004
    ..We speculate that poorer survival of p2mIME cells with a step than with linear increase in NaCl and urea is accounted for, at least in part, by urea-induced suppression of protective genes, particularly HSP70...
  57. pmc Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells
    C M Hao
    Division of Nephrology, Department of Medicine, Vanderbilt George M O Brien Kidney and Urologic Diseases Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    J Clin Invest 106:973-82. 2000
    ..The consequent increase in COX2 expression favors RMIC survival in hypertonic conditions. Inhibition of RMIC COX2 could contribute to NSAID-induced papillary injury...
  58. ncbi Cytokine gene expression profiles in kidney medulla and cortex of obese hypertensive dogs
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Kidney Int 66:713-21. 2004
    The molecular mechanisms linking abnormal kidney function and obesity hypertension are poorly understood. This study compared gene expression profiles in the kidney medulla and cortex of obese and lean dogs.
  59. ncbi The role of Randall's plaques in the pathogenesis of calcium stones
    Brian R Matlaga
    Methodist Hospital Institute for Kidney Stone Disease, Indiana University School of Medicine, International Kidney Stone Institute, Indianapolis, Indiana 46202, USA
    J Urol 177:31-8. 2007
    ..We reviewed in vivo data that have further defined the role of Randall's plaques in stone disease...
  60. pmc Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity
    H Miyakawa
    Division of Nephrology, Johns Hopkins School of Medicine, 963 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 96:2538-42. 1999
    ..In mammals, the kidney medulla is normally hypertonic because of the urinary concentrating mechanism...
  61. ncbi Mechanism of the Na,K-ATPase inhibition by MCS derivatives
    R Stimac
    Department of Biology, University of Konstanz, Konstanz, Germany
    J Membr Biol 205:89-101. 2005
    ..The MCS-inhibited state was found to have bound one cation (H(+), Na(+) or K(+)) in one of the two unspecific binding sites, and at high Na(+) concentrations another Na(+) ion was bound to the highly Na(+)-selective ion-binding site...
  62. ncbi Renal tissue NO and intrarenal haemodynamics during experimental variations of NO content in anaesthetised rats
    M Grzelec-Mojzesowicz
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 58:149-63. 2007
    ..Since inhibition of nNOS decreased medullary NO by 80% and MBF by 20% only, this isoform has probably minor role in the maintenance of medullary perfusion...
  63. ncbi Neonatal sympathectomy reduces NADPH oxidase activity and vascular resistance in spontaneously hypertensive rat kidneys
    Torsten Schlüter
    Institute of Physiology, University of Greifswald, Greifswalder Strasse 11c, D17495 Karlsburg, Germany
    Am J Physiol Regul Integr Comp Physiol 291:R391-9. 2006
    ....
  64. ncbi Enhanced renal expression of preproendothelin mRNA during chronic angiotensin II hypertension
    B T Alexander
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1388-92. 2001
    ..These data indicate that activation of the renal endothelin system by ANG II may play an important role in mediating chronic renal and hypertensive actions of ANG II...
  65. ncbi Long-term regulation of ENaC expression in kidney by angiotensin II
    Kathleen T Beutler
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Hypertension 41:1143-50. 2003
    ..The results support the view that the angiotensin II receptor regulates ENaC abundance, consistent with a role for angiotensin II in regulation of collecting duct function...
  66. ncbi Oxygen-radical regulation of renal blood flow following suprarenal aortic clamping
    Stuart I Myers
    McGuire Research Institute McGuire VA Medical Center and Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0108, USA
    J Vasc Surg 43:577-86. 2006
    ..This study examines the hypothesis that the loss of medullary and cortical microvascular blood flow following SMA-SRACR is due to oxygen-derived free radical down-regulation of endogenous medullary and cortical nitric oxide synthesis...
  67. ncbi Role of NO and COX pathways in mediation of adenosine A1 receptor-induced renal vasoconstriction
    Agnieszka Walkowska
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Exp Biol Med (Maywood) 232:690-4. 2007
    ....
  68. ncbi Renal vascular endothelial growth factor in neonatal obstructive nephropathy. I. Endogenous VEGF
    Laura E Burt
    Dept of Pediatrics, Univ of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 292:F158-67. 2007
    ..Following UUO in the adult, the VEGF receptor is upregulated. Endogenous VEGF may serve an adaptive role in responding to tubular injury caused by UUO and may modulate adaptation by the contralateral kidney...
  69. ncbi P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor
    K J Kelly
    Indiana Center for Biological Microscopy, Department of Medicine, Division of Nephrology, Indiana University, Indianapolis Indiana 46202, USA
    J Am Soc Nephrol 14:128-38. 2003
    ..It is concluded that p53 is an important mediator of apoptosis during states of GTP depletion. Inhibitors of p53 should be considered in the treatment of ischemic renal injury...
  70. ncbi Iodinated contrast induced renal vasoconstriction is due in part to the downregulation of renal cortical and medullary nitric oxide synthesis
    Stuart I Myers
    McGuire Research Institute McGuire Veterans Administration Medical Center and Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    J Vasc Surg 44:383-91. 2006
    ....
  71. ncbi Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL
    K Mutig
    Department of Anatomy, Charite Universitatsmedizin, Berlin, Germany
    Am J Physiol Renal Physiol 293:F1166-77. 2007
    ..Strong V(2)R expression in macula densa may be related to tubulovascular signal transfer...
  72. ncbi Suprarenal aortic clamping and reperfusion decreases medullary and cortical blood flow by decreased endogenous renal nitric oxide and PGE2 synthesis
    Stuart I Myers
    McGuire Research Institute McGuire VA Medical Center and Department of Surgery, Virginia Commonwealth University, 23298, USA
    J Vasc Surg 42:524-31. 2005
    ....
  73. ncbi Functional role of ETB receptors in the renal medulla
    Ivanka Vassileva
    Vascular Biology Center, Department of Surgery, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 41:1359-63. 2003
    ..Taken together, these findings support the hypothesis that endothelin plays an important role in regulating sodium excretion through activation of ETB receptors...
  74. ncbi N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis
    Shai Efrati
    Nephrology Division, Research and Development Unit, Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin 70300, and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrol Dial Transplant 22:1873-81. 2007
    ..N-acetylcysteine (NAC) has renoprotective properties. We examined effects of NAC in a rat model of NSAID-induced renal failure...
  75. ncbi Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450
    L Dobrowolski
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Acta Physiol (Oxf) 189:77-85. 2007
    ....
  76. ncbi Effect of exogenous angiotensin II on renal tissue nitric oxide and intrarenal circulation in anaesthetized rats
    B Badzynska
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Acta Physiol Scand 182:313-8. 2004
    ..This possibility was evaluated by a simultaneous determination of the effect of exogenous Ang II on renal cortical and medullary tissue NO and on intrarenal circulation...
  77. ncbi Ovariectomy enhances renal cortical expression and function of cyclooxygenase-2
    Yuko Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Int 66:1966-76. 2004
    ..This study was performed to determine the renal expression of COX-2 and on COX-2-dependent regulation of renal blood flow (RBF) in ovariectomized rats...
  78. ncbi Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat
    Per Liss
    Department of Diagnostic Radiology, University Hospital, 75185 Uppsala, Sweden
    Eur Radiol 14:1297-302. 2004
    ....
  79. ncbi Specific features and roles of renal circulation: angiotensin II revisited
    J Sadowski
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 57:169-78. 2006
    ..We conclude that angiotensin II, acting via AT1 receptors, constricts the renal cortical vasculature; in the medulla its action is effectively buffered by prostaglandin E2 but most probably not by nitric oxide...
  80. ncbi Acute regulation of the epithelial sodium channel gene by vasopressin and hyperosmolality
    Kenji Machida
    Department of Nephrology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Hypertens Res 26:629-34. 2003
    ..Determining the physiological significance of the acute effect of vasopressin in MAL will require further investigations...
  81. ncbi Effects of glycyrrhizin on renal functions in association with the regulation of water channels
    Dae Gill Kang
    Professional Graduate School of Oriental Medicine, and Medicinal Resources Research Center, Wonkwang University, Iksan, Chonbuk, 570 749, Korea
    Am J Chin Med 31:403-13. 2003
    ..These results suggest that the retention of water and salt in glycyrrhizin-treated rats is, at least in part, accounted for by the increased expression of AQP 2 and 3 in the kidney, which may be causally related to the MR...
  82. ncbi Regulation of the Cl-/HCO3- exchanger AE2 in rat thick ascending limb of Henle's loop in response to changes in acid-base and sodium balance
    Fabienne Quentin
    Unité INSERM 356, Institut de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    J Am Soc Nephrol 15:2988-97. 2004
    ..The present study also emphasizes the contribution of cortical TAL adaptation in the renal regulation of acid-base status...
  83. ncbi Vasopressin-independent regulation of collecting duct aquaporin-2 in food deprivation
    Catherine Wilke
    Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    Kidney Int 67:201-16. 2005
    ....
  84. ncbi The effects of carbon dioxide versus ioxaglate in the rat kidney
    Fredrik Palm
    Department of Oncology, Uppsala University, Biomedical Center, Box 571, SE 751 23 Uppsala, Sweden
    J Vasc Interv Radiol 16:269-74. 2005
    ..The gas carbon dioxide is frequently used as an alternative to iodinated contrast medium in these patients. In this study, the renal effects of CO(2) are investigated and compared with those of the iodinated contrast medium ioxaglate...
  85. ncbi Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI
    Jakob Nielsen
    The Water and Salt Research Center, Institute of Anatomy Bldg 233, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 285:F1198-209. 2003
    ....
  86. ncbi Antioxidant treatment prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension
    Niu Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA
    Hypertension 45:934-9. 2005
    ..Antioxidant treatment with vitamins C and E improves renal dysfunction, lessens renal injury, and decreases arterial pressure in Dahl salt-sensitive hypertension...
  87. ncbi Type 1A angiotensin II receptor is regulated differently in proximal and distal nephron segments
    Ken Imanishi
    Third Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Hypertens Res 26:405-11. 2003
    ..The finding that AT1 was up-regulated in the medulla during dehydration may suggest that this receptor plays an important role in dehydration in the distal tubules...
  88. ncbi Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension
    F Palm
    Department of Medical Cell Biology, Biomedical Center, Box 571, 751 23 Uppsala, Sweden
    Diabetologia 46:1153-60. 2003
    ....
  89. ncbi Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats
    M Kuczeriszka
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 57:179-85. 2006
    ..The data document, for the first in the whole kidney studies, the functional antagonism of 20-HETE and NO...
  90. ncbi Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function
    M Barthelmebs
    Institut de Pharmacologie, Faculte de Medecine, Strasbourg, France
    Diabetes Metab 29:163-70. 2003
    ....
  91. ncbi Dopamine is metabolised by different enzymes along the rat nephron
    Fernando R Ibarra
    Laboratorio de Riñón Experimental, Instituto de Investigaciones Medicas A Lanari, Combatientes de Malvinas, 3150 C1427ARO, Buenos Aires, Argentina
    Pflugers Arch 450:185-91. 2005
    ..Our results show that DA is present all along the rat nephron and that renal DA is metabolised continuously and predominantly by MAO in proximal segments, and by COMT in the more distal ones...
  92. ncbi Loss of renal function and microvascular blood flow after suprarenal aortic clamping and reperfusion (SPACR) above the superior mesenteric artery is greatly augmented compared with SPACR above the renal arteries
    Stuart I Myers
    McGuire Research Institute McGuire VA Medical Center, Richmond, VA, USA
    J Vasc Surg 45:357-66. 2007
    ..This study examined the hypothesis that SMA-SRACR-induced downregulation of renal blood flow and function is more severe than renal-SRACR owing to the addition of systemic oxygen-derived free radical (ODFR) release...
  93. ncbi Renal hemodynamic responses to intrarenal infusion of acetylcholine: comparison with effects of PGE2 and NO donor
    B Badzynska
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre of the Polish Academy of Sciences, Warsaw
    Kidney Int 69:1774-9. 2006
    ..The reason was probably the Ach's dual opposed action, vasoconstrictor and vasorelaxant, on the intrarenal vasculature...
  94. ncbi Mechanism underlying diuretic effect of L-NAME at a subpressor dose
    M Liang
    Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Renal Physiol 281:F414-9. 2001
    ....
  95. ncbi Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin
    H Hantz
    Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA
    J Pharmacol Exp Ther 299:372-6. 2001
    ..05). These findings are the first to demonstrate that U46619, through activation of ET(A) and ET(B) receptors, elicits renal cortical vasoconstriction and medullary vasodilation in the rat...
  96. pmc Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats
    Minolfa C Prieto-Carrasquero
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Hypertension 51:1590-6. 2008
    ....
  97. ncbi Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC)
    O Staub
    Division of Respiratory Research, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Physiol 272:C1871-80. 1997
    ..We speculate this difference in colocalization may reflect differences in the regulation of channel stability in those tissues...
  98. ncbi Effects of daily sodium intake and ANG II on cortical and medullary renal blood flow in conscious rats
    V Gross
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol 274:R1317-23. 1998
    ..The elevated blood flow to the renal cortex may enhance sodium excretion and contribute to long-term sodium homeostasis...
  99. ncbi Expression of synaptotagmin VIII in rat kidney
    B K Kishore
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda 20892 0951, Maryland
    Am J Physiol 275:F131-42. 1998
    ..We conclude that synaptotagmin VIII is broadly expressed among renal tubule epithelia, raising the possibility that it is involved in regulation of transport and/or cell remodeling at several sites in the nephron and collecting duct...
  100. ncbi The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney
    M Kakoki
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 281:R91-7. 2001
    ..These results suggest that NOS1 does not regulate basal blood flow in the renal cortex or medulla, despite the observation that a considerable portion of NO in the renal interstitial space appears to be produced by NOS1...
  101. ncbi Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney
    H Hager
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 280:F1093-106. 2001
    ..The intracellular vesicular pool in CD principal cells suggests ENaC trafficking as a potential mechanism for the regulation of Na(+) reabsorption...

Research Grants64

  1. The Pathogenesis of Sickle Cell Nephropathy
    Antonio Guasch; Fiscal Year: 2010
    ..kidneys: the glomerulus, causing protein leakage in the urine, renal insufficiency and kidney failure, and the kidney medulla which causes an inability to concentrate the urine, making the patients prone to dehydration...
  2. SIMULATION OF THE RENAL MEDULLA
    DONALD MARSH; Fiscal Year: 1993
    ..This goal has been achieved; we have developed a model that represents the structures of the kidney medulla and the membrane transport functions of those structures...
  3. Calcium Signaling in Vasa Recta Endothelium
    THOMAS PALLONE; Fiscal Year: 2004
    ..We will test whether DVR contractions to norepinephrine, Angll and KCI are increased, measure NO production and assess effects of OH on endothelial and pericyte Ca2+ signaling. ..
  4. VASOMOTOR CONTROL OF DESCENDING VASA RECTA
    THOMAS PALLONE; Fiscal Year: 2003
    ....
  5. MICROVASCULAR TRANSPORT IN THE RENAL MEDULLA
    THOMAS PALLONE; Fiscal Year: 2002
    ..Exchange of albumin and middle molecular weight solutes will also be simulated. ..
  6. Reactive Oxygen Species American Society of Nephrology Fall 2007
    THOMAS PALLONE; Fiscal Year: 2007
    ..Attendance of young scientists insures that the information will be translated into future studies that elucidate the role of ROS in kidney diseases and treatment thereof. [unreadable] [unreadable] [unreadable]..
  7. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  8. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..
  10. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  11. Mathematical Model of Vascular and Tubular Transport in the Rat Outer Medulla
    AURELIE EDWARDS; Fiscal Year: 2008
    ..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
  12. Regulation of Urea Transport by Adrenal Steroids
    JEFF SANDS; Fiscal Year: 2005
    ..Subsequently, cDNA isoforms for facilitated urea transporters were cloned from kidney medulla (UT-A1, UT-A2, UT-A3, UT-A4), testis (UT-A5), and erythrocytes (UT-B)...
  13. Can Studies of Co-Morbidities with TMJDs Reveal Common Mechanisms of Disease?
    Allen Cowley; Fiscal Year: 2008
    ..A major goal of this meeting is to identify common therapeutic targets related to shared co-morbidities. [unreadable] [unreadable] [unreadable]..
  14. Interaction of age and gender on NO bioavailability
    Jennifer Sullivan; Fiscal Year: 2005
    ..We will then determine the affects of age and gender on antioxidant systems and the sources of oxidative stress in the mesenteric vasculature. ..
  15. Mechanisms of Hypertension-induced Renal Injury
    Allen W Cowley; Fiscal Year: 2010
    ..An understanding of these mechanisms could lead to new therapeutic approaches for the prevention of kidney disease in hypertension. ..
  16. Renal 11b-Hydroxysteroid Dehydrogenases and Hypertension
    Mingyu Liang; Fiscal Year: 2008
    ..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..
  17. A Systems Approach to the Understanding of TMJ as a Complex Disease
    Allen Cowley; Fiscal Year: 2006
    ..abstract_text> ..
  18. Advancing Diagnostic Approaches for TMJ Disorders
    Allen Cowley; Fiscal Year: 2004
    ..abstract_text> ..
  19. Joint and Muscle Dysfunction of Temporomandibular Joint
    Allen Cowley; Fiscal Year: 2002
    ....
  20. Role of Organic Osmolytes in Renal Papillary Necrosis
    Gilbert Moeckel; Fiscal Year: 2007
    ..It is necessary to understand these processes in order to design effective diagnostic procedures, therapeutic approaches and preventive measures for RPN. ..
  21. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 2001
    ....
  22. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2006
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  23. Role of COX2 in Medullary Interstitial Cell Survival and Function
    Gilbert Moeckel; Fiscal Year: 2008
    ..It is necessary to understand how these cells function in order to design better drugs to treat high blood pressure. [unreadable] [unreadable]..
  24. P2U(P2Y2)-PURINOCEPTOR AND WATER TRANSPORT IN RAT KIDNEY
    BELLAMKONDA KISHORE; Fiscal Year: 2004
    ..Successful completion of these studies will lead to significant insights into the AVP-independent mechanisms of regulation of collecting duct water permeability. ..
  25. Estrogen in pathogenesis of tubulointerstitial disease
    Christine Maric; Fiscal Year: 2003
    ..abstract_text> ..
  26. MATHEMATICAL MODELS OF RENAL DYNAMICS
    HAROLD LAYTON; Fiscal Year: 2009
    ..abstract_text> ..
  27. Regulation of aquaporin-2 trafficking in collecting duct
    Kay Pong Yip; Fiscal Year: 2006
    ..These may lead a better understand of the role of kidney collecting duct in water balance disorders. ..
  28. 20-HETE IN NO-MEDIATED REGULATION OF RENAL FUNCTION
    Adebayo Oyekan; Fiscal Year: 2001
    ....
  29. Roles of polycystin and calcium in B-Raf signaling
    DARREN WALLACE; Fiscal Year: 2004
    ..2) Determine the mechanism by which the overexpression of the C-terminal fragment of PC1 in M1 cells, a condition thought to disrupt PC1/PC2 function, alters cAMP-dependent B-Raf signaling. ..
  30. Sgk1 in Na+ transport in fetal lung epithelia
    Christie Thomas; Fiscal Year: 2007
    ..abstract_text> ..
  31. MRI Evaluation of Acute Renal Transplant Dysfunction
    Vivian Lee; Fiscal Year: 2008
    ..At its conclusion, our study has a high likelihood of showing that functional MR renography for differentiating intrinsic renal diseases, will be an accurate tool for acute renal transplant dysfunction. ..
  32. Salt Absorption by the THAL: Role of NKCC2 trafficking
    Pablo A Ortiz; Fiscal Year: 2010
    ..Data from this proposal will increase our understanding of how salt absorption by the THAL is regulated in normal and salt-sensitive animals, and will identify new targets for the development of diuretics. ..
  33. Collecting duct endothelin-1 and hypertension
    Donald Kohan; Fiscal Year: 2009
    ..Such information is important in understanding intrarenal mechanisms responsible for hypertension and salt and water retention. ..
  34. Acupuncture in Cardiovascular Disease
    Holly Middlekauff; Fiscal Year: 2002
    ....
  35. MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURE
    Karina Davidson; Fiscal Year: 2008
    ..The ultimate goal will be to make our findings available to 3 target audiences: 1) the network of investigators at Columbia; 2) the behavioral medicine community; and 3) the general medical community. ..
  36. Bladder-specific Knockout and Gene Expression
    Xue ru Wu; Fiscal Year: 2009
    ..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
  37. Regulation of Pendrin by Angiotensin II
    Susan Wall; Fiscal Year: 2007
    ..This proposal will explore how pendrin controls absorption of Cl- by the kidney and why activity of pendrin and ENaC are so dependent on each other. ..
  38. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  39. Proteomic Analysis of Renal Response to Acidosis
    Norman Curthoys; Fiscal Year: 2008
    ..The resulting hypotheses will stimulate future biochemical and pharmacological studies that will improve the treatment of patients who present with various forms of acidosis. [unreadable] [unreadable] [unreadable]..
  40. Protein Biomarker Profiles of Abusive Alcohol Consumption
    Frank Witzmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  42. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..abstract_text> ..
  43. Expression of ammonia-sensitive proteins in the CNS
    I Weiner; Fiscal Year: 2005
    ..Second, while these studies are admittedly high risk, their results could lead to a breakthrough in the field of hyperammonemic and hepatic encephalopathy. ..
  44. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  45. EFFECT OF SHIGATOXIN-1 ON BRAIN ENDOTHELIAL CELLS
    Donald Kohan; Fiscal Year: 2004
    ....
  46. 4th International Symposium on Hormonal Carcinogenesis
    Jonathan Li; Fiscal Year: 2003
    ..abstract_text> ..
  47. PREVENTION OF GRAFT FAILURE TO DIETARY N-3 FATTY ACIDS
    James Tumlin; Fiscal Year: 2002
    ..Secondary outcomes to be compared are molecular markers for thrombosis, inflammation, and vascular risk factors. ..
  48. REGULATION OF RENAL CALCIUM TRANSPORT BY CALCIUM
    John Arthur; Fiscal Year: 2002
    ....
  49. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation of cHKA will significantly enhance our knowledge on a variety of pathologic conditions associated with electrolyte and acid-base abnormalities. ..
  50. Expression of TRPV1 and variant TRPV1 in the kidney
    David Cohen; Fiscal Year: 2005
    ..In addition, such a reagent might have potential therapeutic utility with respect to this important pathway mediating nociception. ..
  51. A Renal Epithelial Urea Sensor
    David Cohen; Fiscal Year: 2005
    ..In addition, the sufficiency of these and related signaling elements for urea signaling will be examined in models of heterologous expression. ..
  52. PEDIATRIC NEPHROLOGY TRAINING
    Michel Baum; Fiscal Year: 2005
    ..Fellows also attend seminars in basic science departments. The research mentor, as well as the program director, closely supervise trainees to ensure that the goals of the training program are achieved. ..
  53. REGULATION OF DEVELOPMENTAL RENAL HEMODYNAMICS
    Michael Solhaug; Fiscal Year: 2005
    ..Identifying the regulatory relationships between AII and NOS may lead to preventive or therapeutic measures to treat neonatal ARF. ..
  54. Multianalyte Assays for Cardiovascular Disease
    Debra Diz; Fiscal Year: 2005
    ..As such the peptide and protein applications developed in this proposal will be ideal for widespread use. ..
  55. Conditioned Placebo Effects & Treatment of Hypertension
    Thomas Pickering; Fiscal Year: 2005
    ..The demonstration of a conditioned placebo effect that produces a sustained reduction of BP could result in more economical treatment with fewer side effects. ..
  56. 5th International Symposium on Hormonal Carcinogenesis
    Jonathan Li; Fiscal Year: 2006
    ..Area 4: Hormone Dependency and Independency. e) In prostate, breast and uterine cancer, Session 6. As in the past, a book will be published of the presentations. [unreadable] [unreadable] [unreadable] [unreadable]..
  57. Role of Myosin II in Ischemic Acute Renal Failure
    Timothy Sutton; Fiscal Year: 2006
    ..Mutant forms of MLCK and ROCK proteins will be co-expressed in MDCK cells to alter cellular signaling. ..
  58. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..These studies will not only examine the pathogenesis of this disorder, but will directly examine if indomethacin potentially represents a novel therapy for this disease. ..
  59. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  60. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
    ..They should further facilitate future investigations into the role of this transporter in pathophysiologic states affecting electrolyte and acid-base homeostasis. ..
  61. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    ..Our goal is to advance the specificity of clinical management and treatment of EH. ..
  62. Magnetic Resonance Renography:Validation Studies
    Vivian Lee; Fiscal Year: 2003
    ..abstract_text> ..
  63. Ninth International Conference on Endothelin (ET-9)
    Donald Kohan; Fiscal Year: 2005
    ..abstract_text> ..