kidney

Summary

Summary: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Top Publications

  1. ncbi Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    P Li
    Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 91:479-89. 1997
  2. pmc Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 18:698-712. 2010
  3. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
  4. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
  5. doi New insights into epithelial-mesenchymal transition in kidney fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 21:212-22. 2010
  6. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
  7. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
  8. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  9. doi Cellular and molecular mechanisms of renal fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Nat Rev Nephrol 7:684-96. 2011
  10. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003

Detail Information

Publications337 found, 100 shown here

  1. ncbi Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    P Li
    Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 91:479-89. 1997
    ....
  2. pmc Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 18:698-712. 2010
    The two major components of the kidney, the collecting system and the nephron, have different developmental histories...
  3. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants...
  4. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    While sepsis is a leading cause of acute kidney injury in critically ill patients, the relationship between immune response and acute kidney injury in less severely ill patients with infection is not known...
  5. doi New insights into epithelial-mesenchymal transition in kidney fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 21:212-22. 2010
    ..However, the degree to which this process contributes to kidney fibrosis remains a matter of intense debate and is likely to be context-dependent...
  6. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
  7. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
    ..NHANES III) serum creatinine assay provide a basis for estimating the prevalence and distribution of chronic kidney disease (CKD) in the United States using standardized criteria based on estimated glomerular filtration rate (GFR) ..
  8. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  9. doi Cellular and molecular mechanisms of renal fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Nat Rev Nephrol 7:684-96. 2011
    ..fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of prognosis and a major determinant of renal insufficiency...
  10. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  11. ncbi Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
    J Am Soc Nephrol 16:3365-70. 2005
    The marginal effects of acute kidney injury on in-hospital mortality, length of stay (LOS), and costs have not been well described...
  12. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
    ..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
  13. pmc Macrophage diversity in renal injury and repair
    Sharon D Ricardo
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    J Clin Invest 118:3522-30. 2008
    ..and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses...
  14. ncbi Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
    Florian Tögel
    Division of Nephrology, University of Utah, Salt Lake City, UT 84148, USA
    Am J Physiol Renal Physiol 289:F31-42. 2005
    ..the outcome through amelioration of inflammatory, vascular, and apoptotic/necrotic manifestations of ischemic kidney injury...
  15. pmc Cellular pathophysiology of ischemic acute kidney injury
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 121:4210-21. 2011
    Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis...
  16. pmc Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
    Wilhelm Kriz
    Department of Anatomy and Developmental Biology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Clin Invest 121:468-74. 2011
    ..Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking.
  17. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
    Understanding the origin of myofibroblasts in kidney is of great interest because these cells are responsible for scar formation in fibrotic kidney disease...
  18. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..Using bone marrow chimeras and transgenic reporter mice, we show here that interstitial kidney fibroblasts derive from two sources...
  19. pmc LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
    Martin C Herzig
    Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Hum Mol Genet 20:4209-23. 2011
    ..knock-out, KO) showed an early-onset (age 6 weeks) marked increase in number and size of secondary lysosomes in kidney proximal tubule cells and lamellar bodies in lung type II cells...
  20. pmc Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    G J Pazour
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biol 151:709-18. 2000
    ..Mice with defects in Tg737 die shortly after birth from polycystic kidney disease. We show that the primary cilia in the kidney of Tg737 mutant mice are shorter than normal...
  21. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
    ..TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation...
  22. doi Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
    The current staging system for chronic kidney disease is based primarily on estimated glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse outcomes...
  23. ncbi The classification of glomerulonephritis in systemic lupus erythematosus revisited
    Jan J Weening
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Nephrol 15:241-50. 2004
    ..We hope that this revision, which evolved under the auspices of the International Society of Nephrology and the Renal Pathology Society, will contribute to further advancement of the WHO classification...
  24. pmc Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
    Brad C Astor
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Kidney Int 79:1331-40. 2011
    ..rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD)...
  25. pmc Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Japan
    J Clin Invest 120:1043-55. 2010
    ..Here, we investigated in mice the mechanisms underlying CR-mediated protection against hypoxia in aged kidney, with a special focus on the role of the NAD-dependent deacetylase sirtuin 1 (Sirt1), which is linked to CR-..
  26. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
    ..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
  27. ncbi Chronic kidney disease: the global challenge
    A Meguid El Nahas
    Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
    Lancet 365:331-40. 2005
    The worldwide rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal failure necessitating renal replacement therapy is threatening to reach epidemic proportions over the next decade, and only a ..
  28. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..The extent to which they contribute to innate immunity is, however, unknown. We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI ..
  29. ncbi Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure
    Marina Morigi
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    J Am Soc Nephrol 15:1794-804. 2004
    ..and displayed binding sites for Lens culinaris lectin, indicating that mesenchymal stem cells engraft the damaged kidney and differentiate into tubular epithelial cells, thereby restoring renal structure and function...
  30. doi Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
    Lancet 376:1903-9. 2010
    ..We aimed to assess effectiveness and safety of catheter-based renal denervation for reduction of blood pressure in patients with treatment-resistant hypertension...
  31. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
    ..In contrast to the more ubiquitous ACE, ACE2 transcripts are found only in heart, kidney, and testis of 23 human tissues examined...
  32. ncbi Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
    ..However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference...
  33. ncbi Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach
    Alexandre Lautrette
    INSERM U426, Hopital Necker Enfants Malades, IFR 94, Universite Paris 5, 149 rue de Sevres, 75015 Paris, France
    Nat Med 11:867-74. 2005
    ..These findings indicate a crucial role for AngII-dependent EGFR transactivation in renal deterioration and identify in TACE inhibitors a new therapeutic strategy for preventing progression of chronic renal diseases...
  34. ncbi Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
    Toxicol Lett 168:176-85. 2007
    ..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
  35. doi Aldosterone: effects on the kidney and cardiovascular system
    Marie Briet
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Nat Rev Nephrol 6:261-73. 2010
    ..activity, is mainly recognized for its action on sodium reabsorption in the distal nephron of the kidney, which is mediated by the epithelial sodium channel (ENaC)...
  36. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
    With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure.
  37. ncbi Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    Lindolfo da Silva Meirelles
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Cell Sci 119:2204-13. 2006
    ..characteristics can be derived and propagated in vitro from different organs and tissues (brain, spleen, liver, kidney, lung, bone marrow, muscle, thymus, pancreas); (2) MSC long-term cultures can be generated from large blood ..
  38. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
    ..In the kidney, all of the RAS components are present and intrarenal angiotensin II (Ang II) is formed by independent multiple ..
  39. pmc Identification of a microRNA signature of renal ischemia reperfusion injury
    Jonathan G Godwin
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14339-44. 2010
    ..However, overexpression of miR-21 alone was not sufficient to prevent TEC death following ischemia. Our findings therefore define a molecular fingerprint of renal injury and suggest miR-21 may play a role in protecting TEC from death...
  40. pmc Distinct macrophage phenotypes contribute to kidney injury and repair
    Sik Lee
    Yale University School of Medicine, 333 Cedar Street, PO Box 208029, New Haven, CT 06510, USA
    J Am Soc Nephrol 22:317-26. 2011
    The ischemically injured kidney undergoes tubular cell necrosis and apoptosis, accompanied by an interstitial inflammatory cell infiltrate...
  41. ncbi Update on mechanisms of ischemic acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, OH 45229 3039, USA
    J Am Soc Nephrol 17:1503-20. 2006
  42. doi Mitochondria, reactive oxygen species and cadmium toxicity in the kidney
    Glenda Gobe
    Centre for Kidney Disease Research, University of Queensland School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane 4102, Australia
    Toxicol Lett 198:49-55. 2010
    The heavy metal cadmium accumulates in kidney cells, particularly those of the proximal tubular epithelium, and the damage this causes is associated with development of chronic kidney disease...
  43. pmc Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    Vera Eremina
    The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 111:707-16. 2003
    b>Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier is often the target of injury...
  44. ncbi A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    M Yoshioka
    Department of Hygiene, Akita University School of Medicine, Japan
    Diabetes 46:887-94. 1997
    ..This locus, which we named Mody4, was mapped to chromosome 7 in a region 2-8 cM distal to D7Mit189 (logarithm of odds [LOD] score = 15.6 and 10.3)...
  45. doi Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study
    Anja Haase-Fielitz
    Department of Intensive Care, Austin Health, Melbourne, Australia
    Crit Care Med 37:553-60. 2009
    To compare the value of novel with conventional serum biomarkers in the prediction of acute kidney injury (AKI) in adult cardiac surgical patients according to preoperative renal function.
  46. ncbi Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB
    Maristela Lika Onozato
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Kidney Int 61:186-94. 2002
    ..We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and nitrotyrosine deposition in the kidneys of rats with diabetes mellitus (DM)...
  47. pmc Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
    Jeremy S Duffield
    Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 115:1743-55. 2005
    Ischemia causes kidney tubular cell damage and abnormal renal function. The kidney is capable of morphological restoration of tubules and recovery of function...
  48. pmc Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    Shuei Liong Lin
    Laboratory of Inflammation Research, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 173:1617-27. 2008
    ..type I, alpha 1 (coll1a1) promoter and enhancers, we examined the origins of coll1a1-producing cells in the kidney. Here we show that in normal kidney, both podocytes and pericytes generate coll1a1 transcripts as detected by ..
  49. ncbi Alport's syndrome, Goodpasture's syndrome, and type IV collagen
    Billy G Hudson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    N Engl J Med 348:2543-56. 2003
  50. pmc Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Thomas L Nickolas
    Columbia University, New York, New York 10032, USA
    Ann Intern Med 148:810-9. 2008
    A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia.
  51. doi Apoptosis and acute kidney injury
    Andrea Havasi
    Renal Section, Department of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Kidney Int 80:29-40. 2011
    Improved mechanistic understanding of renal cell death in acute kidney injury (AKI) has generated new therapeutic targets...
  52. doi Proposal for diagnostic criteria for IgG4-related kidney disease
    Mitsuhiro Kawano
    Division of Rheumatology, Department of Internal Medicine, Kanazawa University Hospital, Kanazawa, Japan
    Clin Exp Nephrol 15:615-26. 2011
    ..by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma cells into multiple organs, with the kidney being one representative target...
  53. ncbi Toward a unified theory of renal progression
    Raymond C Harris
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Med 57:365-80. 2006
    ..New knowledge about the cell biology of progression also suggests that other adjunctive therapies may be possible. We describe the progress and highlight those spheres where new-targeted interventions may arise...
  54. pmc Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 285:34004-15. 2010
    ..These results demonstrate that post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-β-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy...
  55. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
    ..Here, we demonstrate that in the adult human kidney, CD133+CD24+ cells consist of a hierarchical population of progenitors that are arranged in a precise sequence ..
  56. pmc Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
    Hongting Zheng
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
    Diabetes 60:3055-66. 2011
    ..To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabetic nephropathy...
  57. ncbi Obesity-related glomerulopathy: an emerging epidemic
    N Kambham
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Kidney Int 59:1498-509. 2001
    ..The ten-fold increase in incidence over 15 years suggests a newly emerging epidemic. Heightened physician awareness of this entity is needed to ensure accurate diagnosis and appropriate therapy...
  58. doi Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial
    Jianming Tan
    Organ Transplant Institute, Fuzhou General Hospital, Xiamen University and Fujian Key Laboratory of Transplant Biology, Fuzhou, China
    JAMA 307:1169-77. 2012
    Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging...
  59. ncbi Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney
    K J Jung
    Department of Pharmacy, Pusan National University, Busan, Korea
    Inflamm Res 58:143-50. 2009
    To compare the effect of short-term calorie restriction (CR) on aging with that of already known long-term CR, the anti-inflammatory efficacy of 10-day CR was explored in aged rat kidney.
  60. ncbi Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)
    Garabed Eknoyan
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 42:617-22. 2003
  61. doi Structural and functional changes in the kidneys of high-fat diet-induced obese mice
    Naoko Deji
    Dept of Medicine, Shiga Univ of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Am J Physiol Renal Physiol 296:F118-26. 2009
    Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear...
  62. doi Resolved: EMT produces fibroblasts in the kidney
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 21:1247-53. 2010
    ..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate...
  63. ncbi Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury
    Florian Tögel
    Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84148, USA
    Am J Physiol Renal Physiol 292:F1626-35. 2007
    Acute kidney injury (AKI) is a major clinical problem in which a critical vascular, pathophysiological component is recognized...
  64. pmc Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury
    Denise W Wong
    Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 171:438-51. 2007
    ..We examined the effect of deletion of the angiotensin-convert-ing enzyme 2 (Ace2) gene on diabetic kidney injury...
  65. doi Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD
    Pablo E Pergola
    Renal Associates, PA, San Antonio, Tex, USA
    Am J Nephrol 33:469-76. 2011
    ..Bardoxolone methyl, a novel synthetic triterpenoid, induces Nrf2, a transcription factor known to play a key role in decreasing oxidative stress and the production of pro-inflammatory molecules...
  66. ncbi Renal fibrosis: new insights into the pathogenesis and therapeutics
    Youhua Liu
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Kidney Int 69:213-7. 2006
    ..consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease...
  67. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  68. ncbi Modified RIFLE criteria in critically ill children with acute kidney injury
    A Akcan-Arikan
    Renal Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    Kidney Int 71:1028-35. 2007
    A classification system has been proposed to standardize the definition of acute kidney injury in adults. These criteria of risk, injury, failure, loss, and end-stage renal disease were given the acronym of RIFLE...
  69. ncbi Chronic kidney disease management in the United Kingdom: NEOERICA project results
    P E Stevens
    Department of Renal Medicine, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, Kent, UK
    Kidney Int 72:92-9. 2007
    Early identification of patients with chronic kidney disease (CKD) may allow health-care systems to implement interventions aimed at decreasing disease progression and eventual morbidity and mortality...
  70. ncbi Stromal cells protect against acute tubular injury via an endocrine effect
    Baoyuan Bi
    Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Am Soc Nephrol 18:2486-96. 2007
    ..Using the Y chromosome as a marker of donor stromal cells, examination of multiple kidney sections at one or four days after cell infusion failed to reveal any examples of stromal cells within the tubules,..
  71. ncbi Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    T Ichimura
    Renal Unit, Medical Services, Massachusetts General Hospital East, Boston, Massachusetts 02129, USA
    J Biol Chem 273:4135-42. 1998
    ..1 membrane protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is named kidney injury molecule-1 (KIM-1)...
  72. ncbi Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Nature 417:447-52. 2002
    ..The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences...
  73. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage...
  74. doi Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease
    Hisashi Hasegawa
    Innovative Drug Research Laboratories, Kyowa Hakko Kirin, Tokyo, Japan
    Kidney Int 78:975-80. 2010
    Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with early chronic kidney disease (CKD) and are postulated to cause low blood levels of 1,25-dihydroxyvitamin D, as well as normal phosphate levels...
  75. doi Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease
    Adriana S Dusso
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Kidney Int 79:715-29. 2011
    In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and skeletal disorders predisposing to renal and ..
  76. pmc Multiple loci associated with indices of renal function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 41:712-7. 2009
    Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity...
  77. ncbi Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats
    L L Woods
    Division of Nephrology, Oregon Health Sciences University, 3181 S W Sam Jackson Park Rd, Portland, Oregon 97201 3098, U S A
    Pediatr Res 49:460-7. 2001
    ..5%, LP) diet throughout gestation. Birth weight was reduced by 13% (p < 0.0005), and the kidney/body weight ratio was reduced in LP pups...
  78. ncbi Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    Claudia Lange
    Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
    Kidney Int 68:1613-7. 2005
    ..The aim of this study was, therefore, to evaluate the therapeutic effectiveness of bone marrow-derived mesenchymal stem cells in a rat model of ischemia/reperfusion (I/R) ARF...
  79. ncbi Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
    Jian Kang Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, S 3223 Medical Center North, Nashville, Tennessee 37232, USA
    J Am Soc Nephrol 16:1384-91. 2005
    Loss of functioning nephrons stimulates the growth of residual kidney tissue to augment work capacity and maintain normal renal function. This growth largely occurs by hypertrophy rather than from hyperplasia of the remaining nephrons...
  80. pmc Atlas of gene expression in the developing kidney at microanatomic resolution
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Cell 15:781-91. 2008
    b>Kidney development is based on differential cell-type-specific expression of a vast number of genes...
  81. ncbi The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death
    H Putaala
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Hum Mol Genet 10:1-8. 2001
    ..In the cerebellum, the expression was seen in radial glial cells. Neither anatomical nor morphological abnormalities were observed in the brains of null mice...
  82. ncbi Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment
    Kylie Georgas
    NHMRC Principal Research Fellow, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    Dev Biol 332:273-86. 2009
    ..form a renal vesicle (RV), the subsequent patterning of the nephron and fusion with the ureteric component of the kidney to form a patent contiguous uriniferous tubule has not been fully characterized...
  83. ncbi Kidney function is related to cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Stroke 39:55-61. 2008
    Poor kidney function, as measured by glomerular filtration rate (GFR), is closely associated with presence of glomerular small vessel disease...
  84. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  85. ncbi BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
    G Luo
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:2808-20. 1995
    ..BMP-7-deficient mice die shortly after birth because of poor kidney development...
  86. ncbi A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    A T Dudley
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 9:2795-807. 1995
    ..The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye...
  87. ncbi Aquaporins in the kidney: from molecules to medicine
    Søren Nielsen
    The Water and Salt Research Center, Institute of Anatomy, and Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
    Physiol Rev 82:205-44. 2002
    ..In the kidney, at least seven aquaporins are expressed at distinct sites...
  88. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
    ..ureteric epithelium and the metanephric mesenchyme are needed to drive growth and differentiation of the embryonic kidney to completion...
  89. pmc Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice
    S Ghosh
    Dept of Anaesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, Univ of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Am J Physiol Renal Physiol 296:F700-8. 2009
    ..Reductions in caspase-3 and caspase-8 activities, with parallel improvements in SOD expression and reduced oxidative damage, could underlie the beneficial effects of exercise in diabetic kidney disease.
  90. ncbi Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment
    K M Park
    Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129-2060, USA
    J Biol Chem 276:11870-6. 2001
    ..Unilateral ischemia was also protective against a subsequent ischemic insult to the same kidney, revealing that systemic uremia is not necessary for protection...
  91. pmc TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
    Thomas T Chen
    Veterans Administration Medical Center, San Francisco, CA 94121, USA
    J Exp Med 202:955-65. 2005
    ..immunoglobulin-domain and mucin-domain (TIM) proteins constitute a receptor family that was identified first on kidney and liver cells; recently it was also shown to be expressed on T cells...
  92. pmc The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex
    Chao Ling Yang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 117:3403-11. 2007
    ..Previous work showed that WNK1, WNK4, and a kidney-specific isoform of WNK1 interact to regulate NCC activity, suggesting that WNK kinases form a signaling complex...
  93. ncbi Podocyte biology and response to injury
    Peter Mundel
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Soc Nephrol 13:3005-15. 2002
  94. doi Insulin signaling to the glomerular podocyte is critical for normal kidney function
    Gavin I Welsh
    Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK
    Cell Metab 12:329-40. 2010
    ..Collectively, this work reveals the critical importance of podocyte insulin sensitivity for kidney function.
  95. doi The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential
    Hiroyuki Mori
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 384:471-5. 2009
    ..These results indicate that mTOR activation plays a pivotal role in the development of ESRD and that rapamycin could be an effective therapeutic agent for DN...
  96. pmc Methylation determines fibroblast activation and fibrogenesis in the kidney
    Wibke Bechtel
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:544-50. 2010
    ..of the Ras oncoprotein, is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney. RASAL1 hypermethylation is mediated by the methyltransferase Dnmt1 in renal fibrogenesis, and kidney fibrosis is ..
  97. ncbi Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods
    Recep Cetin
    Ankara Oncology Education and Search Hospital, Department of General Surgery, Ankara, Turkey
    J Appl Toxicol 26:42-6. 2006
    ..glutathione peroxidase and catalase enzymes, and antioxidant potential value) parameters were measured in kidney tissues of the groups. Histopathological examination was also performed...
  98. pmc Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging
    Heather E Wheeler
    Department of Genetics, Stanford University Medical Center, Stanford, California, USA
    PLoS Genet 5:e1000685. 2009
    ..and expression quantitative trait loci (eQTL) mapping to narrow down which genes to test for association with kidney aging...
  99. pmc Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney
    Chun Cheng Hou
    Department of Medicine, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Am J Pathol 166:761-71. 2005
    ..We hypothesized that blocking TGF-beta1 signaling could attenuate renal fibrosis in a rat model of remnant kidney disease...
  100. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
    ..we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15))...
  101. doi Cellular maintenance and repair of the kidney
    Jian Kan Guo
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Annu Rev Physiol 72:357-76. 2010
    The mammalian kidney is a highly complex organ that requires the precise structural arrangement of multiple cell types for effective function...

Research Grants162 found, 100 shown here

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Cardiac Physiology and Imaging Core for Mouse in Vivo
    Kirk Peterson; Fiscal Year: 2009
    ..AAV) after the operation, animals are euthanized by an overdose of sodium pentobarbital (100 mg/kg) and the heart, kidney, lungs and liver are quickly removed, embedded in OCT compound (Miles, IN), frozen in isopentane precooled with ..
  3. Tissue Culture Laboratory
    Joseph Goldstein; Fiscal Year: 2009
    ..human fibroblasts, Chinese hamster ovary (CHO) cells, Sp2/O-Ag14 myeloma cells, simian COS cells, human embryonic kidney (HEK)-293 cells, rat-1 fibroblasts, mouse embryonic fibroblasts, human lymphoblastoid cells, HeLa cells, rat FT02B ..
  4. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..It is life saving when used on the surfaces of solid visceral organs, such as the liver spleen, pancreas and kidney, involved in trauma, cancer and transplantation in presence of coagulopathies or anticoagulation...
  5. Fibrotic Sequelae of Childhood Renal Disease
    Agnes Fogo; Fiscal Year: 2007
    ..cardiovascular complications in ch^Jkn with chronic kidney disease, Jabs p^Pbses to test if carotid artery intima media thickness can be used as a surrogate marker for the ..
  6. EFFICACY OF MOTIVATIONAL INTERVIEW TO LOWER DIABETES RISK IN AFRICAN AMERICANS
    LEWIS BLUE; Fiscal Year: 2011
    ..2001). Diabetes and its complications (heart disease, stroke, and hypertension, kidney disease, blindness, and distal neuropathy and amputation) are leading causes of morbidity and mortality in the U.S...
  7. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2010
    ..by applicant): We have found that endothelial dysfunction develops early in human hypertension and chronic kidney disease (CKD). It is accompanied by increased reactive oxygen species (ROS) which can inactivate nitric oxide (NO)...
  8. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Kidney disease that is identified by the appearance of large amounts of protein in the urine, edema or swelling of ..
  9. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Kidney disease that is identified by the appearance of large amounts of protein in the urine, edema or swelling of ..
  10. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..toxic pro-oxidant chemicals, and it is very common in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic kidney disease. Veterans have high prevalence of T2DM, diabetic kidney disease, and associated OS...
  11. Angiotensin Adrenergic Interactions in the Kidney
    Roland Blantz; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Project Summary/Abstract In the normal kidney glomerular filtration rate (GFR) is accompanied by parallel changes in Na reabsorption (TNa)...
  12. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary/Abstract In the normal kidney glomerular filtration rate (GFR) is accompanied by parallel changes in Na reabsorption (TNa)...
  13. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2013
    ..implicated in the pathogenesis of many human diseases including disorders of mineral metabolism and chronic kidney disease...
  14. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2010
    ..UTs are highly expressed in many mammalian tissues, including kidney, liver, and brain...
  15. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..UTs are highly expressed in many mammalian tissues, including kidney, liver, and brain...
  16. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    CHARLES S contact WINGO; Fiscal Year: 2010
    ..The present application will characterize the induction of ET-1 by aldosterone in the kidney and the role of ET-1 in the regulation of renal Na transport...
  17. Project 1 Targacept, Inc.
    Merouane Bencherif; Fiscal Year: 2011
    ..g. ethanol), it is difficult to determine whether these behavioral effects are due to varenicline, underlying psychiatric issues or substance abuse issues, or the act of smoking cessation itself. ..
  18. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..g. kidney and lung) in which a significant number of the same cells resides...
  19. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
  20. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..6 million people dying from cancer in 2007. More people in the US die of lung cancer than breast, colon, kidney, and prostate cancers combined...
  21. Regulation of mural cells during pulmonary capillary formation
    Stephen McGowan; Fiscal Year: 2009
    ..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
  22. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..These results strongly suggest that PC1 functions to silence STAT6 activity in the normal healthy kidney. Cessation of lumenal fluid flow, e.g...
  23. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2010
    ..Mgat5 deficient 129/Sv mice develop late onset spontaneous kidney autoimmunity and are more susceptible to experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  24. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..Mgat5 deficient 129/Sv mice develop late onset spontaneous kidney autoimmunity and are more susceptible to experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  25. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2012
    ..Mgat5 deficient 129/Sv mice develop late onset spontaneous kidney autoimmunity and are more susceptible to experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  26. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2010
    ..Mgat5 deficient 129/Sv mice develop late onset spontaneous kidney autoimmunity and are more susceptible to experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  27. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2010
    ..Throughout the trial, we will monitor the safety and tolerability of this combination treatment. ..
  28. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2010
    ..discovery for major human diseases including diabetes, obesity, hypercholesterolemia, colon cancer, and chronic kidney disease, most of which represent a huge burden on public health...
  29. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2012
    ..discovery for major human diseases including diabetes, obesity, hypercholesterolemia, colon cancer, and chronic kidney disease, most of which represent a huge burden on public health...
  30. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..However, such studies are lacking in kidney cancer...
  31. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..2 will probe the role of 1,25(OH)2D3-VDR to stimulate calcium and phosphate translocation in small intestine and kidney through the enhanced expression of epithelial calcium transporter 1 (TRPV6) and sodium-phosphate cotransporter 2c (..
  32. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2011
    ..induces local increases in PG synthesis, specifically prostaglandin E2 (PGE2), which is measurable in urine and kidney. PGE2 is a potent inhibitor of Na and water reabsorption in the inner medullary collecting duct (IMCD)...
  33. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..is an assistant professor of anesthesiology conducting translational research that tests mechanisms of acute kidney injury (AKI) following cardiac surgery...
  34. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2010
    ..on the short- and long-term pathological consequences of IR in other radiosensitive tissues, including liver, kidney and lung. The frequency and severity of fibrosis and cancer development will be assessed in a mouse model...
  35. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..than the general population of developing cancer of the urinary tract, liver, pancreas, colon, endometrium and kidney. Diabetes and hyperglycemia are associated with enhanced production of reactive oxygen species and induce DNA ..
  36. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..The research will provide important information on the basis and possible treatment of primary systemic amyloidosis that may lead to improvement in survival in these patients. ..
  37. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..In kidney and intestinal epithelial cells the Na,K-ATPase is strictly delivered to the basolateral membrane providing ..
  38. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia Savin; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Kidney disease that is identified by the appearance of large amounts of protein in the urine, edema or swelling of ..
  39. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2003
    ..The cpk mouse was the first polycystic kidney disease (PKD) model to be described and as such, it has been the most extensively characterized...
  40. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2002
    ..The cpk mouse was the first polycystic kidney disease (PKD) model to be described and as such, it has been the most extensively characterized...
  41. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2001
    ..The cpk mouse was the first polycystic kidney disease (PKD) model to be described and as such, it has been the most extensively characterized...
  42. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2000
    ..The cpk mouse was the first polycystic kidney disease (PKD) model to be described and as such, it has been the most extensively characterized...
  43. Inflammation and T Cell Memory: Inter-related Barriers to Allograft Tolerance
    Terry Strom; Fiscal Year: 2009
    ..drug toxicity, and malignancies emphasizes the limitations of chronically administered immunosuppression in kidney and islet transplantations...
  44. Inflammation and T Cell Memory: Inter-related Barriers to Allograft Tolerance
    Terry Strom; Fiscal Year: 2007
    ..drug toxicity, and malignancies emphasizes the limitations of chronically administered immunosuppression in kidney and islet transplantations...
  45. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..Background: Chronic kidney diseases (CKD) take one of the highest tolls on human health...
  46. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2009
    ..Background: Chronic kidney diseases (CKD) take one of the highest tolls on human health...
  47. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..The degree to which poor health status results from kidney failure versus other associated diseases versus imperfections and complications of dialysis is unknown...
  48. Culturally Adapted Strategies to Enhance Kidney Donation in Native Communities
    Dedra S Buchwald; Fiscal Year: 2012
    ..Despite similar referral rates for kidney transplantation, AIs are less likely than Whites to be placed on the transplant waiting list or to receive a ..
  49. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    Glenn Chertow; Fiscal Year: 2009
    ..The degree to which poor health status results from kidney failure versus other associated diseases versus imperfections and complications of dialysis is unknown...
  50. Ca2+-Sensing Receptor: Novel Roles in Calcium Homeostasis
    Edward M Brown; Fiscal Year: 2009
    ..the CaR but also the thyroidal, calcitonin (CT)-secreting C-cells and cells in several nephron segments within the kidney, as well as various other tissues...
  51. Probiotic-Induced Elimination of Oxalate to Treat Hyperoxaluria Associated with P
    Marguerite Hatch; Fiscal Year: 2010
    ..of managing two different clinical entities having in common an increased urinary excretion of oxalate leading to kidney stone formation...
  52. Mechanisms of luminal protein targeting in kidney and hepatic epithelial cells
    ANNE MUESCH; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mechanisms of luminal protein targeting in kidney and hepatic epithelial cells Columnar epithelia (e.g...
  53. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..determine the effects of omega-3 fatty acid supplementation on urine protein excretion in adults with diabetes and kidney disease defined by the presence proteinuria...
  54. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    Edgar Miller; Fiscal Year: 2009
    ..determine the effects of omega-3 fatty acid supplementation on urine protein excretion in adults with diabetes and kidney disease defined by the presence proteinuria...
  55. Role of Insulin Receptors in the Kidney
    CAROLYN MARY ECELBARGER; Fiscal Year: 2011
    ..However, mechanisms underlying these associations are in dire need of clarification. For example, in the kidney, insulin, through its own receptor, can lead to sodium retention, and activate the epithelial sodium channel (ENaC)..
  56. Role of Insulin Receptors in the Kidney
    CAROLYN MARY ECELBARGER; Fiscal Year: 2010
    ..However, mechanisms underlying these associations are in dire need of clarification. For example, in the kidney, insulin, through its own receptor, can lead to sodium retention, and activate the epithelial sodium channel (ENaC)..
  57. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..is to test the feasibility of microRNA-based therapeutics as a novel strategy for the treatment of rare cystic kidney diseases...
  58. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2009
    ..is to test the feasibility of microRNA-based therapeutics as a novel strategy for the treatment of rare cystic kidney diseases...
  59. PREVENTING CONTRAST-INDUCED NEPHROPATHY
    Ali Hassan; Fiscal Year: 2009
    ..These iodinated agents are toxic to the kidney, and exposure can lead to contrast induced nephropathy (CIN), a form of acute kidney failure, in patients with pre-..
  60. Identification of a Multi-Analyte Profile for Primary Hyperoxaluria
    James Mapes; Fiscal Year: 2009
    ..identification of the AGTX mutation, there is little genotype-phenotype correlation in these patients, with kidney stone formation and loss of kidney function proceeding in a seemingly haphazard fashion...
  61. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..that moderately elevated serum uric acid is a strong, independent predictor of an increased risk of chronic kidney disease and increased rates of loss of kidney function among T1D persons...
  62. Dialysis Chains and Access to Cadaveric Renal Transplantation Therapy
    Yi Zhang; Fiscal Year: 2011
    ..S. among dialysis patients suffering from End Stage Renal Disease (ESRD). Kidney transplantation rates differ by sociodemographic characteristics, yet the reasons for this variation are not fully ..
  63. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chronic kidney disease (CKD), end stage renal disease and their complications are a public health problem of epidemic proportions...
  64. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): 6. PROJECT SUMMARY/ABSTRACT Most vital organs in the body (Kidney, Intestine, Liver, Lung, Glands) are composed of epithelial cells which carry out the main functions of the organ, necessary for ..
  65. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): 6. PROJECT SUMMARY/ABSTRACT Most vital organs in the body (Kidney, Intestine, Liver, Lung, Glands) are composed of epithelial cells which carry out the main functions of the organ, necessary for ..
  66. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
    PROJECT SUMMARY / ABSTRACT Small intestine and kidney tubules play essential roles in the absorption and homeostatic balance of salt and carbohydrates...
  67. A Novel Device for Determination of GFR Markers
    Bikas Vaidya; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): About 20 million Americans have chronic kidney disease while an additional 20 million are at risk. Over the next 10 years, the number of patients in the U.S...
  68. Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney
    PETER MADRAS; Fiscal Year: 2007
    ..NIH SBIR Phase I Grant Application Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney During Partial Nephrectomy Project Summary/Abstract Nephron-sparing surgery has become more common for the ..
  69. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 1999
    ..this project are to identify the cis-acting regulatory elements and transcription factors that are responsible for kidney-specific gene expression...
  70. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 1999
    ..this project are to identify the cis-acting regulatory elements and transcription factors that are responsible for kidney-specific gene expression...
  71. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2012
    ..provided by applicant): This project aims to test the hypothesis that tolerance to MHC mismatched living related kidney transplant can be effectively and safely achieved by establishing a stable immune mixed chimeric state in non-..
  72. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Kidney transplantation is the most effective therapeutic modality for end-stage renal disease...
  73. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Kidney transplantation is the most effective therapeutic modality for end-stage renal disease...
  74. Development of a National Incompatible Kidney Transplant Registry
    Robert Montgomery; Fiscal Year: 2009
    ..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving ..
  75. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving ..
  76. Novel endonuclease-targeted approaches to nephroprotection
    Alexei Basnakian; Fiscal Year: 2009
    ABSTRACT The kidney is an excreting organ that is affected by many toxic chemicals metabolized in the body, including products of rhabdomyolysis (skeletal muscle degradation), which are known to induce acute renal injury (AKI) through ..