Genomes and Genes
Summary: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Publications291 found, 100 shown here
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeP Li
Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
Cell 91:479-89. 1997....
- Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney developmentFrank Costantini
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 18:698-712. 2010The two major components of the kidney, the collecting system and the nephron, have different developmental histories...
- New loci associated with kidney function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 42:376-84. 2010Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants...
- Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survivalRaghavan Murugan
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 77:527-35. 2010While sepsis is a leading cause of acute kidney injury in critically ill patients, the relationship between immune response and acute kidney injury in less severely ill patients with infection is not known...
- New insights into epithelial-mesenchymal transition in kidney fibrosisYouhua Liu
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 21:212-22. 2010..However, the degree to which this process contributes to kidney fibrosis remains a matter of intense debate and is likely to be context-dependent...
- Epithelial-mesenchymal transition and its implications for fibrosisRaghu Kalluri
Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
J Clin Invest 112:1776-84. 2003..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
- Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidneyShinji Kume
Department of Medicine, Shiga University of Medical Science, Japan
J Clin Invest 120:1043-55. 2010..Here, we investigated in mice the mechanisms underlying CR-mediated protection against hypoxia in aged kidney, with a special focus on the role of the NAD-dependent deacetylase sirtuin 1 (Sirt1), which is linked to CR-..
- Evidence that fibroblasts derive from epithelium during tissue fibrosisMasayuki Iwano
Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Clin Invest 110:341-50. 2002..Using bone marrow chimeras and transgenic reporter mice, we show here that interstitial kidney fibroblasts derive from two sources...
- Acute kidney injury, mortality, length of stay, and costs in hospitalized patientsGlenn M Chertow
Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
J Am Soc Nephrol 16:3365-70. 2005The marginal effects of acute kidney injury on in-hospital mortality, length of stay (LOS), and costs have not been well described...
- Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trialMurray D Esler
Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
Lancet 376:1903-9. 2010..We aimed to assess effectiveness and safety of catheter-based renal denervation for reduction of blood pressure in patients with treatment-resistant hypertension...
- Mesenchymal stem cells reside in virtually all post-natal organs and tissuesLindolfo da Silva Meirelles
, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Cell Sci 119:2204-13. 2006..characteristics can be derived and propagated in vitro from different organs and tissues (brain, spleen, liver, kidney, lung, bone marrow, muscle, thymus, pancreas); (2) MSC long-term cultures can be generated from large blood ..
- Chronic kidney disease: the global challengeA Meguid El Nahas
Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
Lancet 365:331-40. 2005The worldwide rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal failure necessitating renal replacement therapy is threatening to reach epidemic proportions over the next decade, and only a ..
- Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseasesVera Eremina
The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Clin Invest 111:707-16. 2003b>Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier is often the target of injury...
- Resolved: EMT produces fibroblasts in the kidneyMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Soc Nephrol 21:1247-53. 2010..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate...
- Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort studyAnja Haase-Fielitz
Department of Intensive Care, Austin Health, Melbourne, Australia
Crit Care Med 37:553-60. 2009To compare the value of novel with conventional serum biomarkers in the prediction of acute kidney injury (AKI) in adult cardiac surgical patients according to preoperative renal function.
- Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injuryThomas L Nickolas
Columbia University, New York, New York 10032, USA
Ann Intern Med 148:810-9. 2008A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia.
- Assessing kidney function--measured and estimated glomerular filtration rateLesley A Stevens
Division of Nephrology, Tufts-New England Medical Center, Boston, MA 02111, USA
N Engl J Med 354:2473-83. 2006
- Structural and functional changes in the kidneys of high-fat diet-induced obese miceNaoko Deji
Dept of Medicine, Shiga Univ of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
Am J Physiol Renal Physiol 296:F118-26. 2009Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear...
- Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)Garabed Eknoyan
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Am J Kidney Dis 42:617-22. 2003
- Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidneyK J Jung
Department of Pharmacy, Pusan National University, Busan, Korea
Inflamm Res 58:143-50. 2009To compare the effect of short-term calorie restriction (CR) on aging with that of already known long-term CR, the anti-inflammatory efficacy of 10-day CR was explored in aged rat kidney.
- Modified RIFLE criteria in critically ill children with acute kidney injuryA Akcan Arikan
Renal Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
Kidney Int 71:1028-35. 2007A classification system has been proposed to standardize the definition of acute kidney injury in adults. These criteria of risk, injury, failure, loss, and end-stage renal disease were given the acronym of RIFLE...
- Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital systemThomas J Carroll
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Dev Cell 9:283-92. 2005..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
- Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injuryKiyoshi Mori
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 115:610-21. 2005..In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage...
- Molecular identification of a renal urate anion exchanger that regulates blood urate levelsAtsushi Enomoto
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
Nature 417:447-52. 2002..The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences...
- Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injuryT Ichimura
Renal Unit, Medical Services, Massachusetts General Hospital East, Boston, Massachusetts 02129, USA
J Biol Chem 273:4135-42. 1998..1 membrane protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is named kidney injury molecule-1 (KIM-1)...
- Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segmentKylie Georgas
NHMRC Principal Research Fellow, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
Dev Biol 332:273-86. 2009..form a renal vesicle (RV), the subsequent patterning of the nephron and fusion with the ureteric component of the kidney to form a patent contiguous uriniferous tubule has not been fully characterized...
- Atlas of gene expression in the developing kidney at microanatomic resolutionEric W Brunskill
Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Dev Cell 15:781-91. 2008b>Kidney development is based on differential cell-type-specific expression of a vast number of genes...
- Kidney function is related to cerebral small vessel diseaseM Arfan Ikram
Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
Stroke 39:55-61. 2008Poor kidney function, as measured by glomerular filtration rate (GFR), is closely associated with presence of glomerular small vessel disease...
- The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal deathH Putaala
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
Hum Mol Genet 10:1-8. 2001..In the cerebellum, the expression was seen in radial glial cells. Neither anatomical nor morphological abnormalities were observed in the brains of null mice...
- Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 176:85-97. 2010Understanding the origin of myofibroblasts in kidney is of great interest because these cells are responsible for scar formation in fibrotic kidney disease...
- Role of mammalian target of rapamycin signaling in compensatory renal hypertrophyJian Kang Chen
Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, S 3223 Medical Center North, Nashville, Tennessee 37232, USA
J Am Soc Nephrol 16:1384-91. 2005Loss of functioning nephrons stimulates the growth of residual kidney tissue to augment work capacity and maintain normal renal function. This growth largely occurs by hypertrophy rather than from hyperplasia of the remaining nephrons...
- The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasionJ Comijn
Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
Mol Cell 7:1267-78. 2001..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
- BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterningG Luo
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Genes Dev 9:2808-20. 1995..BMP-7-deficient mice die shortly after birth because of poor kidney development...
- A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eyeA T Dudley
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 9:2795-807. 1995..The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye...
- Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKDPablo E Pergola
Renal Associates, PA, San Antonio, Tex, USA
Am J Nephrol 33:469-76. 2011..Bardoxolone methyl, a novel synthetic triterpenoid, induces Nrf2, a transcription factor known to play a key role in decreasing oxidative stress and the production of pro-inflammatory molecules...
- Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db miceS Ghosh
Dept of Anaesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, Univ of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Am J Physiol Renal Physiol 296:F700-8. 2009..Reductions in caspase-3 and caspase-8 activities, with parallel improvements in SOD expression and reduced oxidative damage, could underlie the beneficial effects of exercise in diabetic kidney disease.
- Aquaporins in the kidney: from molecules to medicineSøren Nielsen
The Water and Salt Research Center, Institute of Anatomy, and Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
Physiol Rev 82:205-44. 2002..In the kidney, at least seven aquaporins are expressed at distinct sites...
- Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney developmentArindam Majumdar
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 130:3175-85. 2003..ureteric epithelium and the metanephric mesenchyme are needed to drive growth and differentiation of the embryonic kidney to completion...
- Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foodsRecep Cetin
Ankara Oncology Education and Search Hospital, Department of General Surgery, Ankara, Turkey
J Appl Toxicol 26:42-6. 2006..glutathione peroxidase and catalase enzymes, and antioxidant potential value) parameters were measured in kidney tissues of the groups. Histopathological examination was also performed...
- Podocyte biology and response to injuryPeter Mundel
Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA
J Am Soc Nephrol 13:3005-15. 2002
- TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosisThomas T Chen
Veterans Administration Medical Center, San Francisco, CA 94121, USA
J Exp Med 202:955-65. 2005..immunoglobulin-domain and mucin-domain (TIM) proteins constitute a receptor family that was identified first on kidney and liver cells; recently it was also shown to be expressed on T cells...
- The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potentialHiroyuki Mori
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Biochem Biophys Res Commun 384:471-5. 2009..These results indicate that mTOR activation plays a pivotal role in the development of ESRD and that rapamycin could be an effective therapeutic agent for DN...
- The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complexChao Ling Yang
Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Clin Invest 117:3403-11. 2007..Previous work showed that WNK1, WNK4, and a kidney-specific isoform of WNK1 interact to regulate NCC activity, suggesting that WNK kinases form a signaling complex...
- Genetic loci influencing kidney function and chronic kidney diseaseJohn C Chambers
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
Nat Genet 42:373-5. 2010..we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15))...
- Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidneyChun Cheng Hou
Department of Medicine, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Am J Pathol 166:761-71. 2005..We hypothesized that blocking TGF-beta1 signaling could attenuate renal fibrosis in a rat model of remnant kidney disease...
- Cellular maintenance and repair of the kidneyJian Kan Guo
Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Annu Rev Physiol 72:357-76. 2010The mammalian kidney is a highly complex organ that requires the precise structural arrangement of multiple cell types for effective function...
- Aquaporins in kidney pathophysiologyYumi Noda
Department of Nephrology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
Nat Rev Nephrol 6:168-78. 2010..This Review describes recent progress in uncovering the physiology and pathophysiology of aquaporins in the kidney, with particular attention devoted to AQP2, the most well-studied member of this protein group.
- Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatmentK M Park
Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129-2060, USA
J Biol Chem 276:11870-6. 2001..Unilateral ischemia was also protective against a subsequent ischemic insult to the same kidney, revealing that systemic uremia is not necessary for protection...
- Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney agingHeather E Wheeler
Department of Genetics, Stanford University Medical Center, Stanford, California, USA
PLoS Genet 5:e1000685. 2009..and expression quantitative trait loci (eQTL) mapping to narrow down which genes to test for association with kidney aging...
- Insulin signaling to the glomerular podocyte is critical for normal kidney functionGavin I Welsh
Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK
Cell Metab 12:329-40. 2010..Collectively, this work reveals the critical importance of podocyte insulin sensitivity for kidney function.
- Methylation determines fibroblast activation and fibrogenesis in the kidneyWibke Bechtel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:544-50. 2010..of the Ras oncoprotein, is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney. RASAL1 hypermethylation is mediated by the methyltransferase Dnmt1 in renal fibrogenesis, and kidney fibrosis is ..
- Roles of interferon-gamma and interleukin-4 in murine lupusS L Peng
Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Clin Invest 99:1936-46. 1997....
- The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional studyHiroyuki Ito
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan
Cardiovasc Diabetol 9:18. 2010To study the relationship between the intima-media thickness (IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic nephropathy graded by the urinary ..
- Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunctionKevin Damman
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur J Heart Fail 9:872-8. 2007..Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion...
- Transforming growth factor beta in tissue fibrosisW A Border
Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
N Engl J Med 331:1286-92. 1994
- Multiple loci associated with indices of renal function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 41:712-7. 2009Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity...
- Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetesGiuseppe Remuzzi
Mario Negri Institute for Pharmacological Research, Bergamo, Italy
J Clin Invest 116:288-96. 2006The incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem...
- The role of epithelial-to-mesenchymal transition in renal fibrosisMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
J Mol Med 82:175-81. 2004..transition (EMT) involving injured epithelial cells plays an important role in the progression of fibrosis in the kidney. Tubular epithelial cells can acquire a mesenchymal phenotype, and enhanced migratory capacity enabling them to ..
- The kidney, hypertension, and obesityJohn E Hall
Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Hypertension 41:625-33. 2003....
- Distinct macrophage phenotypes contribute to kidney injury and repairSik Lee
Yale University School of Medicine, 333 Cedar Street, PO Box 208029, New Haven, CT 06510, USA
J Am Soc Nephrol 22:317-26. 2011The ischemically injured kidney undergoes tubular cell necrosis and apoptosis, accompanied by an interstitial inflammatory cell infiltrate...
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in miceMartin C Herzig
Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
Hum Mol Genet 20:4209-23. 2011..knock-out, KO) showed an early-onset (age 6 weeks) marked increase in number and size of secondary lysosomes in kidney proximal tubule cells and lamellar bodies in lung type II cells...
- HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinomaBelén Lucas
Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, D 45122 Essen, Germany
Oncogene 24:6418-31. 2005..Although HNF4alpha is highly expressed in some sections of the kidney, little is known about its role in this organ and about HNF4alpha-regulated genes in the kidney cells...
- Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathwayMunehiro Kitada
Division of Diabetes and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
Diabetes 60:634-43. 2011..This study examined the renoprotective effects of RSV in db/db mice, a model of type 2 diabetes...
- Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidneyShuei Liong Lin
Laboratory of Inflammation Research, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 173:1617-27. 2008..type I, alpha 1 (coll1a1) promoter and enhancers, we examined the origins of coll1a1-producing cells in the kidney. Here we show that in normal kidney, both podocytes and pericytes generate coll1a1 transcripts as detected by ..
- The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1Raman Agrawal
Department of Cell Biology and Anatomy, LSU Health Sciences Center, MEB 6A12, 1901 Perdido Street, New Orleans, LA 70112, USA
Development 136:3927-36. 2009..To study the role of miRNAs during pronephric kidney development of Xenopus, global miRNA biogenesis was eliminated by knockdown of two key components: Dicer and Dgcr8...
- Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLFK W Foster
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294 3300, USA
Cell Growth Differ 10:423-34. 1999....
- Everolimus in patients with autosomal dominant polycystic kidney diseaseGerd Walz
Renal Division, University Hospital Freiburg, Hugstetter St, 55 79106 Freiburg, Germany
N Engl J Med 363:830-40. 2010Autosomal dominant polycystic kidney disease (ADPKD) is a slowly progressive hereditary disorder that usually leads to end-stage renal disease...
- Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstructionMisako Sato
Department of Pathology, Wakayama Medical University, Wakayama, Japan
J Clin Invest 112:1486-94. 2003..bone marrow monocytes accelerate EMT of the cultured epithelial cells and renal tubules in the obstructed kidney after UUO dependent on Smad3 signaling...
- Temporal events in the intravenous challenge model for experimental Candida albicans infections in female miceDonna M MacCallum
Institute of Medical Sciences, University of Aberdeen, Aberdeen AB5 2ZD, UK
Mycoses 48:151-61. 2005..Variability in mouse survival times, kidney fungal burdens and cachexia was lowest when challenge inocula were within the range 10(4)-10(5) CFU g(-1) body ..
- Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesisCourtney M Karner
Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Nat Genet 41:793-9. 2009..In the kidney, defects in the establishment or maintenance of tubule diameter are associated with one of the most common ..
- Cisplatin nephrotoxicity: a reviewXin Yao
Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas 79430, USA
Am J Med Sci 334:115-24. 2007..Cisplatin is a major antineoplastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity...
- Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesisLi Ma
Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cell 121:179-93. 2005..Our findings position the Ras/MAPK pathway upstream of the TSC complex and suggest that Erk may modulate mTOR signaling and contribute to disease progression through phosphorylation and inactivation of TSC2...
- Regulation of mRNA translation in renal physiology and diseaseBalakuntalam S Kasinath
Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Am J Physiol Renal Physiol 297:F1153-65. 2009..messenger RNA, can be a site of independent regulation of protein synthesis; it has not been well studied in the kidney. Translation occurs in three stages (initiation, elongation, and termination), each with its own set of regulatory ..
- Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylaseHaim Y Cohen
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Science 305:390-2. 2004..Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells...
- Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney developmentAkio Kobayashi
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Development 132:2809-23. 2005b>Kidney organogenesis requires the morphogenesis of epithelial tubules...
- Open partial nephrectomy for tumor in a solitary kidney: experience with 400 casesAmr F Fergany
Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Urol 175:1630-3; discussion 1633. 2006We present a series of 400 patients with tumor in a solitary kidney who underwent open surgical partial nephrectomy performed by a single surgeon (ACN) with a primary focus on postoperative long-term kidney function.
- Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart StudyCaroline S Fox
NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
Kidney Int 66:2017-21. 2004..Because the risk of coronary heart disease is increased even at moderate declines in kidney function, we sought to test whether high CAC scores are seen among those with mild reductions in kidney function.
- Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseasesPierre Meneton
Institut National de la Santé et de la Recherche Médicale U367, Département de Santé Publique et d Informatique Médicale, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
Physiol Rev 85:679-715. 2005..Thus chronic exposure to a high-salt diet appears to be a major factor involved in the frequent occurrence of hypertension and cardiovascular diseases in human populations...
- Fibrogenesis of parenchymal organsTatiana Kisseleva
Department of Medicine, University of California, San Diego, La Jolla, California, USA
Proc Am Thorac Soc 5:338-42. 2008..These concepts open new prospects for multidisciplinary research and the development of new therapies for fibrosis...
- Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cellsMin Lin
Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California 94720, USA
J Biol Chem 278:9856-61. 2003..Northern blot analysis showed expression of RALDH4 mRNA in adult mouse liver and kidney. In situ hybridization revealed expression of RALDH4 in liver on embryo day 14...
- Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporterFiona Rae
Institute for Molecular Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Queensland 4072, Australia
Dev Biol 308:232-46. 2007..Using microarray analysis of FACS-isolated EGFP-positive cells, we show that fetal kidney, lung and brain macrophages show similar gene expression profiles irrespective of their tissue of origin...
- Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null micePaul C Boutros
Bioinformatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto M5G 0A3 Canada
Toxicol Sci 112:245-56. 2009..To address the latter issue, we defined and compared transcriptional responses to dioxin exposure in the liver and kidney of wild-type and Ahr-null adult C57BL/6J mice treated with either 2,3,7,8-tetrachlorodibenzo-p-dioxin or corn-oil ..
- Predictors of loss of residual renal function among new dialysis patientsL M Moist
Department of Medicine, University of Western Ontario, London, Canada
J Am Soc Nephrol 11:556-64. 2000..The observations of demographic groups at risk and potentially modifiable factors and therapies have generated testable hypotheses regarding therapies that may preserve RRF among end-stage renal disease patients...
- Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signalingAndrea Brenner-Anantharam
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
Development 134:1967-75. 2007..Functional experiments utilizing murine metanephric kidney explants show that BMP4, a paracrine factor secreted by tailbud-derived mesenchyme, is required for ureter ..
- Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in miceMohd Shahid
Dept of Physiology, SL 39, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Am J Physiol Renal Physiol 295:F1836-44. 2008..The natriuretic response to TNF-alpha is related to its direct effects on tubular sodium reabsorption...
- Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidneyMelina Narlis
McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
J Am Soc Nephrol 18:1121-9. 2007Pax genes are important regulators of kidney development. In the mouse, homozygous Pax2 inactivation results in renal agenesis, a phenotype that has largely precluded the analysis of Pax gene function during metanephric kidney development...
- Dynamic patterns of gene expression in the developing pronephros of Xenopus laevisT J Carroll
Department of Zoology, University of Texas, Austin 78712, USA
Dev Genet 24:199-207. 1999..in mice have indicated critical roles for Lim-1, Wnt4, WT-1, and Pax-2 in the coordination and execution of kidney patterning and differentiation...
- (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoformsFlorian Lang
Department of Physiology, University of Tuebingen, Tuebingen, Germany
Physiol Rev 86:1151-78. 2006..SGK1 contributes to Na+ retention and K+ elimination of the kidney, mineralocorticoid stimulation of salt appetite, glucocorticoid stimulation of intestinal Na+/H+ exchanger and ..
- HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cellsKaren Grigo
Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, D 45122 Essen, Germany
Biol Chem 389:179-87. 2008..alpha) is down-regulated in RCC and we have shown that HNF4 alpha inhibits cell proliferation in the embryonic kidney cell line HEK293...
- Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patientsK Sharma
Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Kidney Int 51:1980-5. 1997..The clearance of leptin from the circulation is unknown. As the leptin receptor is present in the kidney, we evaluated the role of the kidney in removing circulating leptin in humans...
- Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studiesVishal S Vaidya
Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Biotechnol 28:478-85. 2010b>Kidney toxicity accounts both for the failure of many drug candidates as well as considerable patient morbidity...
- In vitro induction systems for analyses of amphibian organogenesis and body patterningT Ariizumi
CREST, Japan Science and Technology Corporation, The University of Tokyo
Int J Dev Biol 45:273-9. 2001..Activin, in combination with retinoic acid, also induces the formation of the pronephros, a primitive embryonic kidney. The in vitro induced kidney was confirmed to function in vivo in a transplantation experiment...
- Non-cell-autonomous retinoid signaling is crucial for renal developmentCarolina Rosselot
Department of Urology, Columbia University, New York, New York 10032 USA
Development 137:283-92. 2010In humans and mice, mutations in the Ret gene result in Hirschsprung's disease and renal defects. In the embryonic kidney, binding of Ret to its ligand, Gdnf, induces a program of epithelial cell remodeling that controls primary branch ..
- No change in calculated creatinine clearance after tenofovir initiation among Thai patientsAngele Gayet-Ageron
University Hospital of Geneva, Geneva, Switzerland
J Antimicrob Chemother 59:1034-7. 2007..We asked the question whether this higher per kilogram dose was associated with more nephrotoxicity...
- Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model ratsH Asakura
Department of Internal Medicine III, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan
J Thromb Haemost 3:1050-5. 2005..Our results suggest that NO induced by iNOS contributes to hypotension (depressed MAP), the progression of hepatic and renal dysfunction, microthrombus deposition and elevated endothelin levels in the rat model of LPS-induced DIC...
- Melatonin protects against lead-induced hepatic and renal toxicity in male ratsGamal H El-Sokkary
Department of Zoology, Faculty of Science, Assiut University, Assiut 71516, Egypt
Toxicology 213:25-33. 2005..Also, the morphological damage in the liver and kidneys was reduced and the tissues appeared like those of controls. The present study suggests that melatonin may be useful in combating free radical-induced damage due to lead toxicity...
- Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive ratsMayumi Minami
Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo Metropolitan Police Hospital, Tokyo, Japan. mayuminami@ aol.com
Blood Press 14:120-5. 2005..Urinary excretion of nitrite plus nitrate (UNOx) and iron (UFe), and MDA in the kidney were measured after 8 weeks. The renal injury was evaluated by the glomerular sclerosis score (SS)...
- Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT)M J Harris
Molecular Genetics Group, Division of Molecular Medicine, John Curtin School of Medical Research, Australian National University, Canberra ACT 0200, Australia
J Biol Chem 276:20876-81. 2001..multidrug resistance-associated protein 2 (MRP2), is normally expressed in the liver and to a lesser extent in the kidney proximal tubules. In these tissues MRP2 specifically localizes to the apical membrane...
- NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomyPhilipp Kalk
Department of Pharmacology and Toxicology, Center for Cardiovascular Research, Charit, Campus Mitte, Hessische Str. 3-4, Berlin D-10115, Germany
Br J Pharmacol 148:853-9. 2006..Natriuretic peptide plasma levels were also improved by BAY 58-2667. Kidney function and morphology as assessed by creatinine clearance, glomerulosclerosis, interstitial and perivascular ..
- Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in ratsSophie Lanone
INSERM U 700 and U 683, Faculte de Medecine Xavier Bichat, Universite Paris VII, Paris, France
FASEB J 19:1890-2. 2005..These findings indicate that bilirubin can act as an effective agent to reduce mortality and counteract hypotension elicited by endotoxin through mechanisms involving a decreased NOS2 induction secondary to inhibition of NAD(P)H oxidase...
- Acute toxicity of pierisin-1, a cytotoxic protein from Pieris rapae, in mouse and ratAtsushi Shiga
Biosafety Research Center, Foods, Drugs and Pesticides An Pyo Center, 582 2 Shioshinden, Iwata shi, Shizuoka 437 1213, Japan
J Toxicol Sci 31:123-37. 2006..Oral administration of pierisin-1 at a dose of 10,000 microg/kg in BALB/c mice did not exert any obvious effects. Thus, existence of species and strain differences in toxicity of pierisin-1 to animals was demonstrated...
Research Grants103 found, 100 shown here
- Fibrotic Sequelae of Childhood Renal DiseaseAgnes Fogo; Fiscal Year: 2007..cardiovascular complications in ch^Jkn with chronic kidney disease, Jabs p^Pbses to test if carotid artery intima media thickness can be used as a surrogate marker for the ..
- NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSChristopher S Wilcox; Fiscal Year: 2010We have found that endothelial dysfunction develops early in human hypertension and chronic kidney disease (CKD). It is accompanied by increased reactive oxygen species (ROS) which can inactivate nitric oxide (NO)...
- BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSELisa Guay Woodford; Fiscal Year: 2003..The cpk mouse was the first polycystic kidney disease (PKD) model to be described and as such, it has been the most extensively characterized...
- Structure and function of urea transportersMing Zhou; Fiscal Year: 2010..UTs are highly expressed in many mammalian tissues, including kidney, liver, and brain...
- Inflammation and T Cell Memory: Inter-related Barriers to Allograft ToleranceTerry Strom; Fiscal Year: 2007..drug toxicity, and malignancies emphasizes the limitations of chronically administered immunosuppression in kidney and islet transplantations...
- Ca2+-Sensing Receptor: Novel Roles in Calcium HomeostasisEdward M Brown; Fiscal Year: 2009..the CaR but also the thyroidal, calcitonin (CT)-secreting C-cells and cells in several nephron segments within the kidney, as well as various other tissues...
- Probiotic-Induced Elimination of Oxalate to Treat Hyperoxaluria Associated with PMarguerite Hatch; Fiscal Year: 2010..of managing two different clinical entities having in common an increased urinary excretion of oxalate leading to kidney stone formation...
- Role of Insulin Receptors in the KidneyCAROLYN MARY ECELBARGER; Fiscal Year: 2010..However, mechanisms underlying these associations are in dire need of clarification. For example, in the kidney, insulin, through its own receptor, can lead to sodium retention, and activate the epithelial sodium channel (ENaC)..
- The Postischemia Inflammatory Syndrome in the Aged KidneyKATHERINE JULIA KELLY; Fiscal Year: 2010Chronic kidney disease (CKD), end stage renal disease and their complications are a public health problem of epidemic proportions...
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSEnrique Rodriguez Boulan; Fiscal Year: 20096. PROJECT SUMMARY/ABSTRACT Most vital organs in the body (Kidney, Intestine, Liver, Lung, Glands) are composed of epithelial cells which carry out the main functions of the organ, necessary for survival of the organism...
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 20106. PROJECT SUMMARY/ABSTRACT Most vital organs in the body (Kidney, Intestine, Liver, Lung, Glands) are composed of epithelial cells which carry out the main functions of the organ, necessary for survival of the organism...
- A Novel Device for Determination of GFR MarkersBikas Vaidya; Fiscal Year: 2007About 20 million Americans have chronic kidney disease while an additional 20 million are at risk. Over the next 10 years, the number of patients in the U.S. with end stage renal disease is expected to double...
- REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSIONPeter Igarashi; Fiscal Year: 1999..this project are to identify the cis-acting regulatory elements and transcription factors that are responsible for kidney-specific gene expression...
- Pathogenesis of Murine Polyomavirus Allograft NephropathyKenneth A Newell; Fiscal Year: 2010..address this problem, we have developed an unique experimental model of polyomavirus infection in mice following kidney transplantation that mimics many of the important features of BKVN in clinical transplantation...
- Microcirculation in Renovascular HypertensionALEJANDRO ROBERTO CHADE; Fiscal Year: 2010..Despite the advances in renal revascularization techniques and stenting, the stenotic kidney often does not improve and even continues to deteriorate after a successful intervention, and the mechanisms ..
- Mast-Cell Renin and Local ANG II FormationRANDI SILVER; Fiscal Year: 2009Progressive kidney disease is characterized by the accumulation of fibrotic mediators in the kidney...
- Polyamine metabolism in heart and kidney ischemic injuryManoocher Soleimani; Fiscal Year: 2005..The pathophysiology of IRI is strikingly similar in heart and kidney, with enhanced production of toxic metabolites (i.e...
- Mast-Cell Renin and Local ANG II FormationRANDI SILVER; Fiscal Year: 2009Progressive kidney disease is characterized by the accumulation of fibrotic mediators in the kidney...
- Eph Kinase Signaling In Renal Epithelial CellsBingcheng Wang; Fiscal Year: 2010..systems that we have established to determine the cellular and molecular bases underlying Eph kinase regulation of kidney development...
- Eph Kinase Signaling In Renal Epithelial CellsBingcheng Wang; Fiscal Year: 2009..systems that we have established to determine the cellular and molecular bases underlying Eph kinase regulation of kidney development...
- Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant RejectionAnupam Agarwal; Fiscal Year: 2007At present approximately 60,000 patients with chronic kidney disease are awaiting a kidney transplant but only 14,000 patients receive a graft each year due to a shortage of donor organs...
- The Aging Kidney in HIV-Infection: biomarkers for early detection of injuryMichael G Shlipak; Fiscal Year: 2010HIV-infected persons are at greater risk of accelerated aging complications, including premature kidney, heart, and bone diseases...
- Disparities in Progression to Renal Replacement TherapyStephen F Derose; Fiscal Year: 2010Chronic kidney disease (CKD) is now recognized as a major public health problem. When the kidneys fail, death inevitably ensues without the aid of dialysis or kidney transplantation...
- Role of Periostin in Polycystic Kidney DiseaseDARREN WALLACE; Fiscal Year: 2009Autosomal dominant polycystic kidney disease (ADPKD) is a hyperplastic disorder in which aberrant growth of tubule epithelial cells causes the formation of numerous fluid-filled cysts, massively enlarged kidneys and progressive loss of ..
- Role of Periostin in Polycystic Kidney DiseaseDarren P Wallace; Fiscal Year: 2010Autosomal dominant polycystic kidney disease (ADPKD) is a hyperplastic disorder in which aberrant growth of tubule epithelial cells causes the formation of numerous fluid-filled cysts, massively enlarged kidneys and progressive loss of ..
- Meprin A Metalloproteinase in Acute Kidney InjuryGUR PRASAD KAUSHAL; Fiscal Year: 2010..metalloendopeptidases of the 'astacin'family, are highly expressed at the brush-border membranes of the kidney proximal tubules. The specific role of meprins during acute kidney injury (AKI) is not fully understood...
- Role of SGLT3 in diabetes-mediated increased renal sodium reabsorptionNiloofar M Tabatabai; Fiscal Year: 2010..b>Kidney expresses SGLT1 and SGLT2 on the apical side of the PT cells...
- The association of lead and cadmium exposure with kidney function in childrenJeffrey Fadrowski; Fiscal Year: 2007To date, factors influencing the rate of decline in kidney function in children are poorly described and understood...
- Understanding Race and Culture in Living Donor Kidney TransplantationLarissa Myaskovsky; Fiscal Year: 2009..are four times as likely as whites to have end stage renal disease (ESRD), but only half as likely to receive kidney transplants, the optimal treatment for ESRD...