kidney

Summary

Summary: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Top Publications

  1. ncbi Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    P Li
    Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 91:479-89. 1997
  2. pmc Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 18:698-712. 2010
  3. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
  4. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
  5. ncbi New insights into epithelial-mesenchymal transition in kidney fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 21:212-22. 2010
  6. ncbi Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
    J Am Soc Nephrol 16:3365-70. 2005
  7. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
  8. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  9. pmc Cellular pathophysiology of ischemic acute kidney injury
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 121:4210-21. 2011
  10. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002

Detail Information

Publications360 found, 100 shown here

  1. ncbi Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    P Li
    Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 91:479-89. 1997
    ....
  2. pmc Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 18:698-712. 2010
    The two major components of the kidney, the collecting system and the nephron, have different developmental histories...
  3. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants...
  4. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    While sepsis is a leading cause of acute kidney injury in critically ill patients, the relationship between immune response and acute kidney injury in less severely ill patients with infection is not known...
  5. ncbi New insights into epithelial-mesenchymal transition in kidney fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 21:212-22. 2010
    ..However, the degree to which this process contributes to kidney fibrosis remains a matter of intense debate and is likely to be context-dependent...
  6. ncbi Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
    J Am Soc Nephrol 16:3365-70. 2005
    The marginal effects of acute kidney injury on in-hospital mortality, length of stay (LOS), and costs have not been well described...
  7. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
    ..NHANES III) serum creatinine assay provide a basis for estimating the prevalence and distribution of chronic kidney disease (CKD) in the United States using standardized criteria based on estimated glomerular filtration rate (GFR) ..
  8. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  9. pmc Cellular pathophysiology of ischemic acute kidney injury
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 121:4210-21. 2011
    Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis...
  10. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..Using bone marrow chimeras and transgenic reporter mice, we show here that interstitial kidney fibroblasts derive from two sources...
  11. ncbi Transforming growth factor beta in tissue fibrosis
    W A Border
    Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
    N Engl J Med 331:1286-92. 1994
  12. ncbi Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
    Florian Tögel
    Division of Nephrology, University of Utah, Salt Lake City, UT 84148, USA
    Am J Physiol Renal Physiol 289:F31-42. 2005
    ..the outcome through amelioration of inflammatory, vascular, and apoptotic/necrotic manifestations of ischemic kidney injury...
  13. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
    Understanding the origin of myofibroblasts in kidney is of great interest because these cells are responsible for scar formation in fibrotic kidney disease...
  14. pmc Age and association of kidney measures with mortality and end-stage renal disease
    Stein I Hallan
    Division of Nephrology, Department of Medicine, St Olav University Hospital, and Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    JAMA 308:2349-60. 2012
    Chronic kidney disease (CKD) is prevalent in older individuals, but the risk implications of low estimated glomerular filtration rate (eGFR) and high albuminuria across the full age range are controversial.
  15. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
  16. ncbi Cellular and molecular mechanisms of renal fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Nat Rev Nephrol 7:684-96. 2011
    ..fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of prognosis and a major determinant of renal insufficiency...
  17. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
    ..In the kidney, all of the RAS components are present and intrarenal angiotensin II (Ang II) is formed by independent multiple ..
  18. pmc Origin and function of myofibroblasts in kidney fibrosis
    Valerie S LeBleu
    Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 19:1047-53. 2013
    ..engineered mice to track, fate map and ablate cells to determine the source and function of myofibroblasts in kidney fibrosis...
  19. ncbi Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
    ..However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference...
  20. pmc Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
    Wilhelm Kriz
    Department of Anatomy and Developmental Biology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Clin Invest 121:468-74. 2011
    ..Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking.
  21. ncbi A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
    Moin A Saleem
    Children s Renal Unit and Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    J Am Soc Nephrol 13:630-8. 2002
    ..In conclusion, the development of this cell line provides a new tool in the study of podocyte biology, which will enable accurate assessment of the behavior of these complex cells in health and disease...
  22. pmc LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
    Martin C Herzig
    Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Hum Mol Genet 20:4209-23. 2011
    ..knock-out, KO) showed an early-onset (age 6 weeks) marked increase in number and size of secondary lysosomes in kidney proximal tubule cells and lamellar bodies in lung type II cells...
  23. pmc Macrophage diversity in renal injury and repair
    Sharon D Ricardo
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    J Clin Invest 118:3522-30. 2008
    ..and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses...
  24. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..The extent to which they contribute to innate immunity is, however, unknown. We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI ..
  25. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
    ..TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation...
  26. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  27. ncbi Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells
    Vincenzo Cantaluppi
    Dialysis and Kidney Transplantation Unit, Department of Internal Medicine, Center for Experimental Medical Research CeRMS and Nephrology, University of Torino, Torino, Italy
    Kidney Int 82:412-27. 2012
    Endothelial progenitor cells are known to reverse acute kidney injury by paracrine mechanisms...
  28. ncbi Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
    Lancet 376:1903-9. 2010
    ..We aimed to assess effectiveness and safety of catheter-based renal denervation for reduction of blood pressure in patients with treatment-resistant hypertension...
  29. ncbi Update on mechanisms of ischemic acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, OH 45229 3039, USA
    J Am Soc Nephrol 17:1503-20. 2006
  30. pmc Tolvaptan in patients with autosomal dominant polycystic kidney disease
    Vicente E Torres
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 367:2407-18. 2012
    The course of autosomal dominant polycystic kidney disease (ADPKD) is often associated with pain, hypertension, and kidney failure...
  31. ncbi Renal fibrosis: new insights into the pathogenesis and therapeutics
    Youhua Liu
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Kidney Int 69:213-7. 2006
    ..consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease...
  32. ncbi Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
    The current staging system for chronic kidney disease is based primarily on estimated glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse outcomes...
  33. ncbi The classification of glomerulonephritis in systemic lupus erythematosus revisited
    Jan J Weening
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Nephrol 15:241-50. 2004
    ..We hope that this revision, which evolved under the auspices of the International Society of Nephrology and the Renal Pathology Society, will contribute to further advancement of the WHO classification...
  34. pmc Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    G J Pazour
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biol 151:709-18. 2000
    ..Mice with defects in Tg737 die shortly after birth from polycystic kidney disease. We show that the primary cilia in the kidney of Tg737 mutant mice are shorter than normal...
  35. ncbi Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
    Toxicol Lett 168:176-85. 2007
    ..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
  36. pmc Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
    Brad C Astor
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Kidney Int 79:1331-40. 2011
    ..rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD)...
  37. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
    ..In contrast to the more ubiquitous ACE, ACE2 transcripts are found only in heart, kidney, and testis of 23 human tissues examined...
  38. pmc Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Japan
    J Clin Invest 120:1043-55. 2010
    ..Here, we investigated in mice the mechanisms underlying CR-mediated protection against hypoxia in aged kidney, with a special focus on the role of the NAD-dependent deacetylase sirtuin 1 (Sirt1), which is linked to CR-..
  39. pmc Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    Misako Sato
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    J Clin Invest 112:1486-94. 2003
    ..bone marrow monocytes accelerate EMT of the cultured epithelial cells and renal tubules in the obstructed kidney after UUO dependent on Smad3 signaling...
  40. pmc Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
    Courtney M Karner
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Genet 41:793-9. 2009
    ..In the kidney, defects in the establishment or maintenance of tubule diameter are associated with one of the most common ..
  41. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
    ..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
  42. ncbi Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure
    Marina Morigi
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    J Am Soc Nephrol 15:1794-804. 2004
    ..and displayed binding sites for Lens culinaris lectin, indicating that mesenchymal stem cells engraft the damaged kidney and differentiate into tubular epithelial cells, thereby restoring renal structure and function...
  43. ncbi Apoptosis and acute kidney injury
    Andrea Havasi
    Renal Section, Department of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Kidney Int 80:29-40. 2011
    Improved mechanistic understanding of renal cell death in acute kidney injury (AKI) has generated new therapeutic targets...
  44. ncbi Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis
    Hans Joachim Anders
    Department of Nephrology, Medizinische Poliklinik der LMU, University of Munich, Munich, Germany
    Kidney Int 80:915-25. 2011
    Chronic kidney disease involves renal inflammation, interstitial fibrosis, and tubular and vascular atrophy. Macrophages seem to foster all of these histomorphological abnormalities, but their specific contributions remain controversial...
  45. ncbi Aldosterone: effects on the kidney and cardiovascular system
    Marie Briet
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Nat Rev Nephrol 6:261-73. 2010
    ..activity, is mainly recognized for its action on sodium reabsorption in the distal nephron of the kidney, which is mediated by the epithelial sodium channel (ENaC)...
  46. ncbi Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach
    Alexandre Lautrette
    INSERM U426, Hopital Necker Enfants Malades, IFR 94, Universite Paris 5, 149 rue de Sevres, 75015 Paris, France
    Nat Med 11:867-74. 2005
    ..These findings indicate a crucial role for AngII-dependent EGFR transactivation in renal deterioration and identify in TACE inhibitors a new therapeutic strategy for preventing progression of chronic renal diseases...
  47. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
    With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure.
  48. ncbi Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    Lindolfo da Silva Meirelles
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Cell Sci 119:2204-13. 2006
    ..characteristics can be derived and propagated in vitro from different organs and tissues (brain, spleen, liver, kidney, lung, bone marrow, muscle, thymus, pancreas); (2) MSC long-term cultures can be generated from large blood ..
  49. ncbi Fluid and nutrient intake and risk of chronic kidney disease
    Giovanni F M Strippoli
    Centre for Kidney Research, NHMRC Centre for Clinical Research Excellence in Renal Medicine, Cochrane Renal Group, The Children s Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia
    Nephrology (Carlton) 16:326-34. 2011
    We evaluated the association between fluid and nutrient intake and chronic kidney disease (CKD).
  50. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
    ..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
  51. ncbi Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury
    Florian Tögel
    Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84148, USA
    Am J Physiol Renal Physiol 292:F1626-35. 2007
    Acute kidney injury (AKI) is a major clinical problem in which a critical vascular, pathophysiological component is recognized...
  52. ncbi Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats
    Wei Jing Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Medical School, 634 18, Keum Am Dong, Jeonju 561 712, South Korea
    J Pharmacol Exp Ther 340:248-55. 2012
    ..The observed renoprotection is probably attributable to inhibition of DPP IV activity, mimicking of incretin action, and activation of the GLP-1R...
  53. pmc Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4
    Ramanjaneyulu Allam
    Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Pettenkoferstr 8a, D 80336 Munich, Germany
    J Am Soc Nephrol 23:1375-88. 2012
    ..Because the induction of proinflammatory cytokines in dendritic cells requires TLR2 and TLR4, these results support the concept that renal damage triggers an innate immune response, which contributes to the pathogenesis of AKI...
  54. pmc Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease
    Stacey Ruiz
    Reata Pharmaceuticals, Irving, Texas, USA
    Kidney Int 83:1029-41. 2013
    Oxidative stress and inflammation are mediators in the development and progression of chronic kidney disease (CKD) and its complications, and they are inseparably linked as each begets and amplifies the other...
  55. ncbi MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells
    Yogita K Adlakha
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Mall Road, Delhi, India
    Cell Mol Life Sci 68:1415-28. 2011
    ..Taken together, our study demonstrates that overexpression of hsa-miR-128 not only induces apoptosis in HEK293T cells but also is an endogenous regulator of Bax protein...
  56. ncbi Stromal cells protect against acute tubular injury via an endocrine effect
    Baoyuan Bi
    Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Am Soc Nephrol 18:2486-96. 2007
    ..Using the Y chromosome as a marker of donor stromal cells, examination of multiple kidney sections at one or four days after cell infusion failed to reveal any examples of stromal cells within the tubules,..
  57. ncbi Chronic kidney disease: the global challenge
    A Meguid El Nahas
    Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
    Lancet 365:331-40. 2005
    The worldwide rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal failure necessitating renal replacement therapy is threatening to reach epidemic proportions over the next decade, and only a ..
  58. ncbi Chronic kidney disease management in the United Kingdom: NEOERICA project results
    P E Stevens
    Department of Renal Medicine, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, Kent, UK
    Kidney Int 72:92-9. 2007
    Early identification of patients with chronic kidney disease (CKD) may allow health-care systems to implement interventions aimed at decreasing disease progression and eventual morbidity and mortality...
  59. pmc Identification of a microRNA signature of renal ischemia reperfusion injury
    Jonathan G Godwin
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14339-44. 2010
    ..However, overexpression of miR-21 alone was not sufficient to prevent TEC death following ischemia. Our findings therefore define a molecular fingerprint of renal injury and suggest miR-21 may play a role in protecting TEC from death...
  60. ncbi Mitochondria, reactive oxygen species and cadmium toxicity in the kidney
    Glenda Gobe
    Centre for Kidney Disease Research, University of Queensland School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane 4102, Australia
    Toxicol Lett 198:49-55. 2010
    The heavy metal cadmium accumulates in kidney cells, particularly those of the proximal tubular epithelium, and the damage this causes is associated with development of chronic kidney disease...
  61. pmc Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    Vera Eremina
    The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 111:707-16. 2003
    b>Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier is often the target of injury...
  62. ncbi Resolved: EMT produces fibroblasts in the kidney
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 21:1247-53. 2010
    ..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate...
  63. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage...
  64. ncbi A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    M Yoshioka
    Department of Hygiene, Akita University School of Medicine, Japan
    Diabetes 46:887-94. 1997
    ..This locus, which we named Mody4, was mapped to chromosome 7 in a region 2-8 cM distal to D7Mit189 (logarithm of odds [LOD] score = 15.6 and 10.3)...
  65. ncbi Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study
    Anja Haase-Fielitz
    Department of Intensive Care, Austin Health, Melbourne, Australia
    Crit Care Med 37:553-60. 2009
    To compare the value of novel with conventional serum biomarkers in the prediction of acute kidney injury (AKI) in adult cardiac surgical patients according to preoperative renal function.
  66. ncbi Role of microRNAs in kidney homeostasis and disease
    Karthikeyan Chandrasekaran
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    Kidney Int 81:617-27. 2012
    ..The miRNA expression profile of the kidney differs greatly from that of other organs, as well as between the different regions in the kidney...
  67. ncbi Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
    We prospectively studied kidney transplants that progressed to failure after a biopsy for clinical indications, aiming to assign a cause to every failure...
  68. ncbi Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles
    Suxing Gui
    Medical College, Soochow University, Suzhou 215123, People s Republic of China
    J Hazard Mater 195:365-70. 2011
    Numerous studies have demonstrated that damage of kidney of mice can be caused by exposure to titanium dioxide nanoparticles (TiO(2) NPs). However, the molecular mechanism of TiO(2) NPs-induced nephric injury remains unclear...
  69. pmc Distinct macrophage phenotypes contribute to kidney injury and repair
    Sik Lee
    Yale University School of Medicine, 333 Cedar Street, PO Box 208029, New Haven, CT 06510, USA
    J Am Soc Nephrol 22:317-26. 2011
    The ischemically injured kidney undergoes tubular cell necrosis and apoptosis, accompanied by an interstitial inflammatory cell infiltrate...
  70. pmc CSF-1 signaling mediates recovery from acute kidney injury
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 122:4519-32. 2012
    Renal tubule epithelia represent the primary site of damage in acute kidney injury (AKI), a process initiated and propagated by the infiltration of macrophages...
  71. ncbi Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy
    M Sedeek
    Kidney Research Centre, Ottawa Hospital Research Institute and Deptartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Am J Physiol Renal Physiol 299:F1348-58. 2010
    ..Expression (gene and protein) of Nox4, p22(phox), and p47(phox), but not Nox1 or Nox2, was increased in kidney cortex, but not medulla, from db/db vs. control mice (db/m) (P < 0.05)...
  72. pmc The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation
    Laura L Yates
    Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire, UK
    Hum Mol Genet 19:4663-76. 2010
    ..On the basis of our mutant mouse study, we suggest that PCP pathway mutations should be sought when NTD and renal malformation co-exist...
  73. ncbi Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine CGM, RIKEN, Yokohama, Japan
    Nat Genet 44:904-9. 2012
    Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance...
  74. ncbi Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, San Antonio, USA
    Endocr Rev 32:515-31. 2011
    ..In this review, we will summarize the available data concerning the mechanism of action, efficacy, and safety of this novel antidiabetic therapeutic approach...
  75. pmc Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation
    Yanhua Zhao
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Diabetes 60:1907-16. 2011
    Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress...
  76. pmc Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging
    Tsutomu Inoue
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    J Am Soc Nephrol 22:1429-34. 2011
    ..imaging (MRI) techniques, diffusion-weighted (DW)-MRI and blood oxygen level-dependent (BOLD)-MRI, to assess kidney fibrosis and hypoxia of the cortex in 142 patients with either diabetic nephropathy (n = 43), CKD without diabetes ..
  77. pmc Physiology and pathophysiology of the calcium-sensing receptor in the kidney
    Daniela Riccardi
    School of Biosciences, Cardiff University, Cardiff, United Kingdom
    Am J Physiol Renal Physiol 298:F485-99. 2010
    ..Subsequent studies have demonstrated that the CaSR is highly expressed in the kidney, where it is capable of integrating signals deriving from the tubular fluid and/or the interstitial plasma...
  78. pmc FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality
    Victoria Shalhoub
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA, USA
    J Clin Invest 122:2543-53. 2012
    Chronic kidney disease-mineral and bone disorder (CKD-MBD) is associated with secondary hyperparathyroidism (HPT) and serum elevations in the phosphaturic hormone FGF23, which may be maladaptive and lead to increased morbidity and ..
  79. pmc Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
    Jeremy S Duffield
    Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 115:1743-55. 2005
    Ischemia causes kidney tubular cell damage and abnormal renal function. The kidney is capable of morphological restoration of tubules and recovery of function...
  80. pmc Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    Shuei Liong Lin
    Laboratory of Inflammation Research, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 173:1617-27. 2008
    ..type I, alpha 1 (coll1a1) promoter and enhancers, we examined the origins of coll1a1-producing cells in the kidney. Here we show that in normal kidney, both podocytes and pericytes generate coll1a1 transcripts as detected by ..
  81. ncbi Alport's syndrome, Goodpasture's syndrome, and type IV collagen
    Billy G Hudson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    N Engl J Med 348:2543-56. 2003
  82. ncbi Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB
    Maristela Lika Onozato
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Kidney Int 61:186-94. 2002
    ..We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and nitrotyrosine deposition in the kidneys of rats with diabetes mellitus (DM)...
  83. pmc Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Thomas L Nickolas
    Columbia University, New York, New York 10032, USA
    Ann Intern Med 148:810-9. 2008
    A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia.
  84. ncbi Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial
    Jianming Tan
    Organ Transplant Institute, Fuzhou General Hospital, Xiamen University and Fujian Key Laboratory of Transplant Biology, Fuzhou, China
    JAMA 307:1169-77. 2012
    Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging...
  85. ncbi Toward a unified theory of renal progression
    Raymond C Harris
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Med 57:365-80. 2006
    ..New knowledge about the cell biology of progression also suggests that other adjunctive therapies may be possible. We describe the progress and highlight those spheres where new-targeted interventions may arise...
  86. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
    ..Here, we demonstrate that in the adult human kidney, CD133+CD24+ cells consist of a hierarchical population of progenitors that are arranged in a precise sequence ..
  87. ncbi Obesity-related glomerulopathy: an emerging epidemic
    N Kambham
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Kidney Int 59:1498-509. 2001
    ..The ten-fold increase in incidence over 15 years suggests a newly emerging epidemic. Heightened physician awareness of this entity is needed to ensure accurate diagnosis and appropriate therapy...
  88. pmc Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
    Hongting Zheng
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
    Diabetes 60:3055-66. 2011
    ..To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabetic nephropathy...
  89. ncbi Proposal for diagnostic criteria for IgG4-related kidney disease
    Mitsuhiro Kawano
    Division of Rheumatology, Department of Internal Medicine, Kanazawa University Hospital, Kanazawa, Japan
    Clin Exp Nephrol 15:615-26. 2011
    ..by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma cells into multiple organs, with the kidney being one representative target...
  90. pmc Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 285:34004-15. 2010
    ..These results demonstrate that post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-β-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy...
  91. ncbi Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney
    K J Jung
    Department of Pharmacy, Pusan National University, Busan, Korea
    Inflamm Res 58:143-50. 2009
    To compare the effect of short-term calorie restriction (CR) on aging with that of already known long-term CR, the anti-inflammatory efficacy of 10-day CR was explored in aged rat kidney.
  92. ncbi Structural and functional changes in the kidneys of high-fat diet-induced obese mice
    Naoko Deji
    Dept of Medicine, Shiga Univ of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Am J Physiol Renal Physiol 296:F118-26. 2009
    Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear...
  93. ncbi Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)
    Garabed Eknoyan
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 42:617-22. 2003
  94. ncbi Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD
    Pablo E Pergola
    Renal Associates, PA, San Antonio, Tex, USA
    Am J Nephrol 33:469-76. 2011
    ..Bardoxolone methyl, a novel synthetic triterpenoid, induces Nrf2, a transcription factor known to play a key role in decreasing oxidative stress and the production of pro-inflammatory molecules...
  95. pmc Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury
    Denise W Wong
    Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 171:438-51. 2007
    ..We examined the effect of deletion of the angiotensin-convert-ing enzyme 2 (Ace2) gene on diabetic kidney injury...
  96. ncbi Modified RIFLE criteria in critically ill children with acute kidney injury
    A Akcan-Arikan
    Renal Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    Kidney Int 71:1028-35. 2007
    A classification system has been proposed to standardize the definition of acute kidney injury in adults. These criteria of risk, injury, failure, loss, and end-stage renal disease were given the acronym of RIFLE...
  97. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  98. ncbi Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    T Ichimura
    Renal Unit, Medical Services, Massachusetts General Hospital East, Boston, Massachusetts 02129, USA
    J Biol Chem 273:4135-42. 1998
    ..1 membrane protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is named kidney injury molecule-1 (KIM-1)...
  99. ncbi Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Nature 417:447-52. 2002
    ..The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences...
  100. ncbi Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease
    Adriana S Dusso
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Kidney Int 79:715-29. 2011
    In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and skeletal disorders predisposing to renal and ..
  101. ncbi Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats
    L L Woods
    Division of Nephrology, Oregon Health Sciences University, 3181 S W Sam Jackson Park Rd, Portland, Oregon 97201 3098, U S A
    Pediatr Res 49:460-7. 2001
    ..5%, LP) diet throughout gestation. Birth weight was reduced by 13% (p < 0.0005), and the kidney/body weight ratio was reduced in LP pups...

Research Grants80

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..It is life saving when used on the surfaces of solid visceral organs, such as the liver spleen, pancreas and kidney, involved in trauma, cancer and transplantation in presence of coagulopathies or anticoagulation...
  3. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Kidney disease that is identified by the appearance of large amounts of protein in the urine, edema or swelling of ..
  4. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..toxic pro-oxidant chemicals, and it is very common in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic kidney disease. Veterans have high prevalence of T2DM, diabetic kidney disease, and associated OS...
  5. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..It is the primary risk-factor for development of stroke and heart failure and the second most common cause of kidney failure...
  6. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary/Abstract In the normal kidney glomerular filtration rate (GFR) is accompanied by parallel changes in Na reabsorption (TNa)...
  7. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2013
    ..implicated in the pathogenesis of many human diseases including disorders of mineral metabolism and chronic kidney disease...
  8. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Tissue levels of R-100 and metabolites from heart, lung, kidney, and liver will be measured, in order to relate plasma and organ drug uptake...
  9. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..The proposed experiments will determine in animal models the efficacy and mechanisms of action responsible for the antifibrotic effects of ajulemic acid (AJA). ..
  10. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..UTs are highly expressed in many mammalian tissues, including kidney, liver, and brain...
  11. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..g. kidney and lung) in which a significant number of the same cells resides...
  12. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
  13. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..6 million people dying from cancer in 2007. More people in the US die of lung cancer than breast, colon, kidney, and prostate cancers combined...
  14. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..Mgat5 deficient 129/Sv mice develop late onset spontaneous kidney autoimmunity and are more susceptible to experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  15. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..However, such studies are lacking in kidney cancer...
  16. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..2 will probe the role of 1,25(OH)2D3-VDR to stimulate calcium and phosphate translocation in small intestine and kidney through the enhanced expression of epithelial calcium transporter 1 (TRPV6) and sodium-phosphate cotransporter 2c (..
  17. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..a measure of PARP activity);and 2) Improved renal function, reflected by the concentration of urinary Kidney Injury Molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)...
  18. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..induces local increases in PG synthesis, specifically prostaglandin E2 (PGE2), which is measurable in urine and kidney. PGE2 is a potent inhibitor of Na and water reabsorption in the inner medullary collecting duct (IMCD)...
  19. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..is an assistant professor of anesthesiology conducting translational research that tests mechanisms of acute kidney injury (AKI) following cardiac surgery...
  20. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..on the short- and long-term pathological consequences of IR in other radiosensitive tissues, including liver, kidney and lung. The frequency and severity of fibrosis and cancer development will be assessed in a mouse model...
  21. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..than the general population of developing cancer of the urinary tract, liver, pancreas, colon, endometrium and kidney. Diabetes and hyperglycemia are associated with enhanced production of reactive oxygen species and induce DNA ..
  22. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..In kidney and intestinal epithelial cells the Na,K-ATPase is strictly delivered to the basolateral membrane providing ..
  23. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..The research will provide important information on the basis and possible treatment of primary systemic amyloidosis that may lead to improvement in survival in these patients. ..
  24. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..goal of becoming an independent academic investigator with a research focus on epithelial ion transport related to kidney physiology and diseases...
  25. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In patients with chronic kidney disease (CKD), there is an increased incidence of low bone mass and fractures and coronary artery calcification and cardiovascular mortality compared to the general ..
  26. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..states such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, inflammatory bowel disease, kidney disease, rheumatoid arthritis and chronic obstructive pulmonary disease, where aberrant MPO activity has been ..
  27. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..invaluable and frequently used diagnostic modality for but its use is complicated by the subsequent development of kidney injury, often to the extent of requiring dialysis, particularly in populations at greatest risk, suh as the ..
  28. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..leading cause of morbidity and mortality worldwide, contributing to cardiovascular disease, stroke, and end stage kidney disease...
  29. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..sequences in mice in order to identify phage and corresponding peptides with high tumor uptake and low kidney retention;2) engineer the optimized peptide motifs into stable small molecular weight cysteine-constrained ..
  30. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    ..regulate sFlt1 and the elucidation of signaling pathways in GEC has broad implication for the study of proteinuric kidney diseases and may provide new therapeutic targets for treatment of hypertension and proteinuria...
  31. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..a prototypical autoimmune disease affecting 300,000 Americans and often associated with glomerulonephritis and kidney failure, is increased by occupational exposure (e.g...
  32. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..fibril deposits containing the AA amyloid protein in different organs throughout the body including heart, kidney, liver, spleen, lungs, skin and gastrointestinal tract, whereby such amyloid fibril accumulation leads to ..
  33. Functional Analysis of the Dual Specificity Kinase NEK1 in Mammalian Meiosis
    JOANNA KIM HOLLOWAY; Fiscal Year: 2011
    ..defects, not only in their fertility, but also show growth defects, cranial-facial abnormalities and polycystic kidney disease...
  34. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..laboratories with over 13 million dollars in annual NIH funding and is one of only nine NIH George O'Brien Kidney Research Centers in the U.S. thus providing Dr. Bhave ample financial, administrative, and scientific support. Dr...
  35. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..approximately 2,800 lung, 2,000 prostate, 700 colorectal, 500 bladder, 300-400 each for stomach, pancreas, and kidney cancers, 300 head and neck, and 1,100 for other sites combined...
  36. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..The present application will characterize the induction of ET-1 by aldosterone in the kidney and the role of ET-1 in the regulation of renal Na transport...
  37. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..For each treatment, liver, kidney and respiratory physiology will be assessed to determine toxicity of the compounds, and in the case of NO donors ..
  38. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..extra salt, its plasma and total body aldo production levels are normal, and it is predisposed to heart and kidney failure...
  39. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is a complication of cardiac surgery with short-term morbidity, increased costs of treatment, and poor long-term outcome...
  40. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycystic kidney disease (PKD) is a "ciliopathic" disease since the loss of cilia or mutations in proteins involved in the function of cilia lead to renal cystic development...
  41. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..and infected individuals must battle a chronic disease that increases their risk of lung disease, heart disease, kidney failure and malignancies...
  42. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..complex (CCC) defined the disease group of "retinal-renal ciliopathies", the most frequent genetic cause of kidney failure in the first 30 years of life...
  43. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mammalian vascular system, lung, and kidney are branched tubular epithelial organs that transport gases or fluids...
  44. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2012
    ..the enzyme, glycine N-methyltransferase, which is abundant in liver, exocrine pancreas and prostate as well as in kidney and intestinal mucosa in lower amounts...
  45. Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy
    Robert L Nussbaum; Fiscal Year: 2013
    ..weight (LMW) proteinuria and aminoaciduria, overlap with those of Dent disease, a disorder that affects only the kidney. Mutations in OCRL account for ~20% of Dent disease patients...
  46. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..that arterial stiffening, by transmitting increased pressure to target tissues, such as distal vessels and the kidney;will promote an inflammatory response and T cell activation, which further increases blood pressure...
  47. Genetic &Functional Analyses of Hypertension Susceptibility Genes
    YEN PEI CHRISTY CHANG; Fiscal Year: 2013
    ..Therefore we will generate cortex- and medulla-enriched human and mouse kidney transcriptomes by RNA sequencing, which is suitable for the detection of novel isoforms and rare transcripts...
  48. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic kidney disease (CKD), end stage renal disease and their complications are a public health problem of epidemic proportions...
  49. Role of Endocytosis and Vesicular Trafficking in Podocyte Health and Filter Integ
    Puneet Garg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The functional kidney filter is likely created by the capillary endothelium, the glomerular basement membrane, and the "slit diaphragm" or specialized intercellular junction that lies between the ..
  50. Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    PEI AN SHIH; Fiscal Year: 2013
    ..I joined the Hypertension Research Lab at the University of California, San Diego in 2007 as a National Kidney Foundation (NKF) Research Fellow...
  51. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..In our previous study, we defined a role for PPAR1 in sodium handling by the kidney and our results showed that deletion of PPAR1 gene caused a defective Na-Cl cotransporter (NCC) activity as ..
  52. Novel CTD inhibitors with synthetic lethality to oncogenic Ras for cancer therapy
    Bingliang Fang; Fiscal Year: 2013
    ..lines showed that oncrasins are active against several cell lines derived from lung, colon, breast, ovary, and kidney cancers and oncrasin-60 lies outside the category of adequately studied classes of antitumor agents, indicating ..
  53. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..Background: Chronic kidney diseases (CKD) take one of the highest tolls on human health...
  54. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ..extrinsic defects will be tested by transplanting fetal spleens (with genetically marked cells) into recipient kidney capsules...
  55. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..Other organs are affected too, including lung, heart, esophagus, intestine, and kidney. Many patients who suffer from scleroderma/SSc also have a loss of pulmonary function...
  56. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..discovery for major human diseases including diabetes, obesity, hypercholesterolemia, colon cancer, and chronic kidney disease, most of which represent a huge burden on public health...
  57. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..that moderately elevated serum uric acid is a strong, independent predictor of an increased risk of chronic kidney disease and increased rates of loss of kidney function among T1D persons...
  58. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..include cardiovascular diseases, stroke, degenerative neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, burns, battlefield trauma, and other devastating conditions...
  59. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Twenty-six million people in America have chronic kidney disease (CKD). Anemia, cardiovascular diseases, secondary hyperparathyroidism, renal osteodystrophy and other complications are common in CKD...
  60. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..Precise and unique information has already been obtained for breast, lung, colon, kidney, ovarian, and pancreatic cancer, and the proposed work will extend analyses to prostate cancer, estrogen receptor ..
  61. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..and renal systems, currently VDRMs are mainly indicated for managing secondary hyperparathyroidism in chronic kidney disease, and to a lesser degree used to treat osteoporosis and psoriasis...
  62. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..Ca2+ release, induction of stress proteins such as transient receptor potential vanilloid receptor 1 (TRPV1) and kidney injury molecule 1 (KIM-1)...
  63. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Twenty-six million people in America have chronic kidney disease (CKD). Diabetes is by far the leading cause of CKD (diabetic nephropathy), accounting for 44% of new cases of dialysis (in 2005)...
  64. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..The degree to which poor health status results from kidney failure versus other associated diseases versus imperfections and complications of dialysis is unknown...
  65. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..determine the effects of omega-3 fatty acid supplementation on urine protein excretion in adults with diabetes and kidney disease defined by the presence proteinuria...
  66. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..is to test the feasibility of microRNA-based therapeutics as a novel strategy for the treatment of rare cystic kidney diseases...
  67. PREVENTING CONTRAST-INDUCED NEPHROPATHY
    Ali Hassan; Fiscal Year: 2009
    ..These iodinated agents are toxic to the kidney, and exposure can lead to contrast induced nephropathy (CIN), a form of acute kidney failure, in patients with pre-..
  68. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..that moderately elevated serum uric acid is a strong, independent predictor of an increased risk of chronic kidney disease and increased rates of loss of kidney function among T1D persons...
  69. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
    PROJECT SUMMARY / ABSTRACT Small intestine and kidney tubules play essential roles in the absorption and homeostatic balance of salt and carbohydrates...
  70. Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney
    PETER MADRAS; Fiscal Year: 2007
    ..NIH SBIR Phase I Grant Application Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney During Partial Nephrectomy Project Summary/Abstract Nephron-sparing surgery has become more common for the ..
  71. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Kidney transplantation is the most effective therapeutic modality for end-stage renal disease...
  72. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving ..
  73. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..applicant): The primary objective of this research proposal, entitled "Urinary biomarkers for recovery after acute kidney injury and prognosis in hospitalized patients," is to evaluate the relationship between early urinary biomarker ..
  74. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..The pathophysiology of IRI is strikingly similar in heart and kidney, with enhanced production of toxic metabolites (i.e...
  75. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Chronic kidney disease (CKD) is a serious global health problem associated with significant morbidity and mortality...
  76. RENALASE DEFICIENCY AND CARDIOVASCULAR COMPLICATIONS OF CHRONIC KIDNEY DISEASE
    Gary V Desir; Fiscal Year: 2010
    ..molecule discovered in our laboratory, for the treatment of cardiovascular complications associated with chronic kidney disease...
  77. Improvement of lithotripters by ultrasound imaging and backscatter tecniques
    Lawrence A Crum; Fiscal Year: 2010
    ..Shock Wave Lithotripsy (SWL) is the most common treatment for kidney stones in the size range from about 2 - 20 mm: Kidney stones afflict 13% of men and 7% of women in the U.S...
  78. GLYCOSYLATED PROTEINS--DEVELOPING DIABETIC KIDNEY
    Edward Skolnik; Fiscal Year: 1993
    ..While most scientists agree that kidney failure in diabetes results from the abnormal diabetic environment, the mechanisms by which a chronic increase in ..
  79. Improved Peptide-based Tumor Targeting Agents Using Phage Display
    Susan L Deutscher; Fiscal Year: 2010
    ..uptake and retention are not clear, it is believed that positively charged peptides bind negatively charged kidney cells resulting in high doses of kidney radiation...
  80. Social Networks and Pathways to Transplant Parity for Black Hemodialysis Patients
    TERI MARIE BROWNE; Fiscal Year: 2010
    ..provided by applicant): The proposed research seeks to address critical gaps in the scientific knowledge on kidney transplant disparity in the United States, and establish a program of meritorious research related to this public ..