bladder

Summary

Top Publications

  1. ncbi Systemic proliferative changes and clinical signs in cynomolgus monkeys administered a recombinant derivative of human epidermal growth factor
    J F Reindel
    Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Pathol 29:159-73. 2001
  2. ncbi Cancer in Circumpolar Inuit 1969-1988. A summary
    N H Nielsen
    Institute of Forensic Medicine, University of Copenhagen, Denmark
    Acta Oncol 35:621-8. 1996
  3. ncbi Multiple primary malignant tumors in patients with hepatocellular carcinoma. A review of 29 patients
    V de Pangher Manzini
    Divisione di Medicina Generale, Ospedale di Monfalcone, Italy
    Tumori 82:245-8. 1996
  4. ncbi The prevalence of cancer: a review of the available data
    R Zanetti
    Piedmont Cancer Registry, Turin, Italy
    Tumori 85:408-13. 1999
  5. ncbi [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]
    M Sano
    Department of Urology, Sapporo Medical University, School of Medicine
    Kansenshogaku Zasshi 68:1306-17. 1994
  6. ncbi Differences in cancer mortality trends between four neighboring north-eastern areas and Italy, 1970-1990
    E Bidoli
    Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano (Pordenone, Italy
    Tumori 81:399-404. 1995
  7. pmc Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
  8. ncbi Carcinogenic activity of the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carcinogenicity of other NTP brominated chemicals
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:541-8. 1997
  9. ncbi Repression of the rat steroidogenic acute regulatory (StAR) protein gene by PGF2alpha is modulated by the negative transcription factor DAX-1
    T W Sandhoff
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, USA
    Endocrine 10:83-91. 1999
  10. ncbi Cancer survival in Sweden during three decades, 1961-1991
    M Stenbeck
    Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden
    Acta Oncol 34:881-91. 1995

Detail Information

Publications372 found, 100 shown here

  1. ncbi Systemic proliferative changes and clinical signs in cynomolgus monkeys administered a recombinant derivative of human epidermal growth factor
    J F Reindel
    Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Pathol 29:159-73. 2001
    ..Microscopically, pronounced dose-related epithelial hypertrophy and hyperplasia were evident in kidney, urinary bladder, skin (epidermis and adnexa), mammary gland, prostate, seminal vesicles, epididymis, uterus, cervix, vagina, ..
  2. ncbi Cancer in Circumpolar Inuit 1969-1988. A summary
    N H Nielsen
    Institute of Forensic Medicine, University of Copenhagen, Denmark
    Acta Oncol 35:621-8. 1996
    ..Low risk was observed for cancer of the bladder, breast, endometrium and prostate, and for non-Hodgkin lymphoma, Hodgkin's disease, leukaemia, multiple myeloma ..
  3. ncbi Multiple primary malignant tumors in patients with hepatocellular carcinoma. A review of 29 patients
    V de Pangher Manzini
    Divisione di Medicina Generale, Ospedale di Monfalcone, Italy
    Tumori 82:245-8. 1996
    ..RESULTS: Tumors associated with HCC were located in: prostate (9 cases), colon-rectum (5), bladder (3), lung (3), stomach (2), gallbladder (2), and brain, breast, oesophagus, pancreas, thyroid, larynx, pleura, ..
  4. ncbi The prevalence of cancer: a review of the available data
    R Zanetti
    Piedmont Cancer Registry, Turin, Italy
    Tumori 85:408-13. 1999
    ..period considered the cancer sites contributing most to cancer prevalence are lung, colon-rectum, prostate and bladder in males, colon-rectum, breast, uterus (both cervix and corpus) and ovary in females...
  5. ncbi [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]
    M Sano
    Department of Urology, Sapporo Medical University, School of Medicine
    Kansenshogaku Zasshi 68:1306-17. 1994
    ..However, the details remain unclear. We used an experimental model of complicated urinary bladder infection and automated simulation of the variations in urinary antimicrobial concentration to study the efficacy ..
  6. ncbi Differences in cancer mortality trends between four neighboring north-eastern areas and Italy, 1970-1990
    E Bidoli
    Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano (Pordenone, Italy
    Tumori 81:399-404. 1995
    ..RESULTS: Unfavorable trends were seen for neoplasms of the upper aerodigestive tract, lung, breast, colorectum, bladder, kidney and pancreas and cutaneous malignant melanoma...
  7. pmc Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
    ..PGI2) synthesis (measured as 6-oxo-PGF1 alpha by radioimmunoassay) was studied in the aorta and urinary bladder using adrenaline, angiotensin II (AII) and acetylcholine (ACh)...
  8. ncbi Carcinogenic activity of the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carcinogenicity of other NTP brominated chemicals
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:541-8. 1997
    ..gland, oral cavity, esophagus, forestomach, small intestine, large intestine, mesothelium, kidney, urinary bladder, lung, thyroid gland, seminal vesicle, hematopoietic system, and pancreas in the male rat; mammary gland, oral ..
  9. ncbi Repression of the rat steroidogenic acute regulatory (StAR) protein gene by PGF2alpha is modulated by the negative transcription factor DAX-1
    T W Sandhoff
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, USA
    Endocrine 10:83-91. 1999
    ..to a luciferase reporter gene (creating p-1862 StAR) and cotransfected into Y1 adrenal tumor cells and HTB9 human bladder carcinoma cells with vectors which encode DAX-1 and SF-1...
  10. ncbi Cancer survival in Sweden during three decades, 1961-1991
    M Stenbeck
    Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden
    Acta Oncol 34:881-91. 1995
    ..No improvements are found for multiple myeloma or cancers of the liver, gall bladder, and pancreas. Small increases are shown for colorectal cancer and cancers of the stomach, oesophagus, and kidney...
  11. ncbi [Obstructive jaundice du to sludge in the common bile duct]
    J Riederer
    , Trier
    Dtsch Med Wochenschr 125:11-4. 2000
    ..Ultrasonography showed a gall bladder filled with biliary sludge and dilatation of the common bile duct and the smaller biliary passages...
  12. ncbi Comparison of two different radiotherapy schedules for spinal cord compression in prostate cancer
    E Maranzano
    Radiation Oncology Center, Policlinico Hospital of Perugia, Italy
    Tumori 84:472-7. 1998
    ..RESULTS: Back pain total response rate was 82%. Effectiveness of RT on motor and bladder capacity was conditioned by pretreatment status of patients...
  13. pmc Modulation by stereoselective inhibition of cyclo-oxygenase of electromechanical coupling in the guinea-pig isolated renal pelvis
    P Santicioli
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:1149-58. 1995
    ..The renal end of the ureter was electrically stimulated while recording the mechanical activity of the renal and bladder ends of the ureter: addition of either (S)-ketoprofen or indomethacin (10 microM) did not effect propagation of ..
  14. ncbi A clinical prediction rule for the diagnosis of ureteral calculi in emergency departments
    T J Elton
    Division of Area Medicine, Mayo Clinic, Rochester, MN 55905
    J Gen Intern Med 8:57-62. 1993
    ..rule could identify emergency department patients with ureteral calculi; 2) whether the kidney, ureter, and bladder (KUB) radiograph provides diagnostic information beyond that obtained from the history and physical examination; ..
  15. pmc Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, England
    Br J Pharmacol 111:1017-22. 1994
    ..p. 0.5-48 h before) caused a time-dependent plasma protein extravasation in the rat urinary bladder with the maximal extravasation occurring at between 2 and 4 h after administration of the drug. 2...
  16. ncbi Utilization of hospital resources by alcoholic and nonalcoholic patients: a prospective study
    M Niquille
    , Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Gen Intern Med 6:216-22. 1991
    ..had the same lengths of stay (16 days), durations of intravenous infusions (six days), and durations of bladder catheterization (one day)...
  17. pmc The biphasic response of rat vesical smooth muscle to ATP
    C Bolego
    Institute of Pharmacological Sciences, University of Milan, Italy
    Br J Pharmacol 114:1557-62. 1995
    ..In this study the effects induced by ATP and ATP analogues on rat bladder strips were characterized at resting tone and in carbachol-prestimulated tissues. 2...
  18. pmc 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle
    E Messori
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Br J Pharmacol 115:677-83. 1995
    1. In isolated detrusor strips from the guinea-pig urinary bladder, contractile responses to electrical field stimulation were mostly mediated by neurally released acetylcholine (ACh) and adenosine 5'-triphosphate (ATP). 2...
  19. pmc Sonographic screening for urinary tract abnormalities in patients with Schistosoma haematobium infection: pitfalls in examining pregnant women
    J Richter
    , Berlin, Germany
    Bull World Health Organ 74:217-21. 1996
    ..In patients with urinary schistosomiasis, focal and/or diffuse urinary bladder wall changes are frequently detected ultrasonically...
  20. ncbi Incidence and survival of brain tumors: a population-based study
    M Sant
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Servizio di Epidemiologia, Milano, Italia
    Tumori 74:243-52. 1988
    ..the Lombardy Cancer Registry (RTL) has recorded all malignant tumors and the benign tumors of the nervous system, bladder and liver occurring in the Varese province...
  21. ncbi [Therapeutic effect of cefluprenam on polymicrobial urinary tract infection associated with Enterococcus faecalis, using the infectious urolithiasis model in rats]
    M Satoh
    Tokyo Research Laboratories, Eisai Co. Ltd
    Kansenshogaku Zasshi 72:371-8. 1998
    ..mirabilis), Pseudomonas aeruginosa (P. aeruginosa) and Enterococcus faecalis (E. faecalis). In order to form bladder stones in rats, a sterile zinc ring was implanted as a foreign body, followed by inoculating P...
  22. ncbi [Study on local immune response in Escherichia coli-induced experimental urinary tract infection in mice--infiltration of Ia-positive cells, macrophages, neutrophils, T cells and B cells]
    T Hirose
    Department of Urology, Sapporo Medical College
    Kansenshogaku Zasshi 66:964-73. 1992
    ..macrophages, neutrophils, T cells (CD4+, CD8+) and IgA positive B cells were significantly infiltrated in the bladder submucosa from 6 hours after bacterial inoculation...
  23. ncbi High dose etretinate and interferon-alpha--a phase I study in squamous cell carcinomas and transitional cell carcinomas
    A D Roth
    Oncosurgery, Geneva University Hospital, Switzerland
    Acta Oncol 38:613-7. 1999
    ..of the lung, head and neck, the esophagus, cervix and the penis, as well as in transitional carcinomas of the bladder. The treatment consisted of etretinate (Tigason) 4 mg/kg/d on 2, 3, 4 and finally 5 consecutive days every other ..
  24. pmc Factors underlying the increased sensitivity to field stimulation of urinary bladder strips from streptozotocin-induced diabetic rats
    T L Tammela
    Division of Urology, Hospital of the University of Pennsylvania, Philadelphia 19104
    Br J Pharmacol 113:195-203. 1994
    1. The responses of bladder strips from control, streptozotocin-diabetic, and sucrose-drinking rats to electrical field stimulation were investigated...
  25. ncbi [Prolonged peridural analgesia (PDA) for postoperative pain therapy after major urologic interventions. Experiences with 172 adult patients]
    M Fügen
    Urologische Universitätsklinik
    Urologe A 39:41-7. 2000
    ..g. cystectomy with bladder substitution), mobilization was impressively unproblematic...
  26. ncbi The lion of the union: the pelvic wound of Joshua Lawrence Chamberlain
    W J Harmon
    Wilford Hall Medical Center, Lackland Air Force Base, University of Texas Health Science Center at San Antonio, 78250, USA
    J Urol 163:713-6. 2000
    ..In particular the most devastating injury was a rifle shot through the pelvis rupturing the bladder and urethra...
  27. pmc Neuropeptide Y in rat detrusor and its effect on nerve-mediated and acetylcholine-evoked contractions
    M M Iravani
    Department of Pharmacological Sciences, Medical School, Newcastle upon Tyne
    Br J Pharmacol 113:95-102. 1994
    ..and isolated organ bath techniques were used to detect the presence of neuropeptide Y (NPY) in the rat urinary bladder and to determine its effect on tone, spontaneous activity and contractile responses of the detrusor muscle to ..
  28. ncbi Vaginal topography does not correlate well with visceral position in women with pelvic organ prolapse
    K Kenton
    Rush Medical College, Chicago, IL 60612-3873, USA
    Int Urogynecol J Pelvic Floor Dysfunct 8:336-9. 1997
    ..The most dependent portion of the bladder, small intestine, rectum and urethrovesical junction was measured...
  29. ncbi 1991 Volvo Award in experimental studies. Cauda equina syndrome: neurologic recovery following immediate, early, or late decompression
    R B Delamarter
    Division of Orthopaedic Surgery, University of California, School of Medicine, Los Angeles
    Spine (Phila Pa 1976) 16:1022-9. 1991
    ..The dogs receiving 24-hour compression remained paraparetic 5-7 days, with bladder dysfunction for 7-10 days and tail dysfunction persisting for 4 weeks...
  30. ncbi Comparative aspects of contraceptive steroids--effects observed in beagle dogs
    A N Johnson
    R W Johnson Pharmaceutical Research Institute, Ortho Pharmaceutical Corporation, Raritan, New Jersey 08869
    Toxicol Pathol 17:389-95. 1989
    ..of the tubular genitalia, and occasionally in the transitional epithelium of the neck/trigone area of the urinary bladder. The contraceptive formulations used in humans are balanced with an E:P ratio of about 1:5 to 1:80 to produce a ..
  31. ncbi Disparate circadian variations of blood pressure and body temperature in bedridden elderly patients with cerebral atrophy
    M Tominaga
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Am J Hypertens 8:773-81. 1995
    ..blood pressure (BP) and pulse rate monitorings were done with simultaneous measurement of urinary bladder temperature. Urine was also collected every 4 h to measure 17-hydroxycorticosterone and catecholamines...
  32. ncbi Cancer mortality in migrant populations within Italy
    M A Vigotti
    Laboratorio di Fisiologia Clinica, Pisa, Italy
    Tumori 74:107-28. 1988
    ..g., mouth or pharynx, esophagus, larynx, stomach or bladder) than for others (e.g., intestines or breast)...
  33. ncbi Video-assisted percutaneous cystoscopy of the bladder and prostatic urethra in the dog: new approach for visual laser ablation of the prostate
    S J Van Lue
    Department of Small Animal Medicine, University of Georgia, Athens, USA
    J Endourol 9:503-7. 1995
    A new minimally invasive approach for video laparoscopy was developed to access the bladder and prostatic urethra of the dog in order to perform laser ablation of the prostate without using either an open laparotomy or urethrostomy...
  34. pmc Involvement of multiple receptors in the biological effects of calcitonin gene-related peptide and amylin in rat and guinea-pig preparations
    S Giuliani
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 107:510-4. 1992
    ..isolated left atrium (electrically driven), in mucosa-free strips from the base of the guinea-pig urinary bladder and in the rat isolated vas deferens (pars prostatica)...
  35. ncbi Examination of lesions in the urinary bladder and kidney of dogs induced by nefiracetam, a new nootropic agent
    Y Kashida
    Drug Safety Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Toxicol Pathol 24:549-57. 1996
    Toxic lesions induced by nefiracetam, a nootropic drug, in the urinary bladder and kidney were examined by repeated oral administration of 300 mg/kg/day for 1, 2, 3, 4, or 11 wk to male and female beagle dogs...
  36. ncbi Flow cytometric and immunohistochemical correlations in high incidence human solid tumors
    D T Danesi
    Sezione di Tossicologia e Scienze Biomediche, ENEA CR Casaccia, Rome, Italy
    Tumori 83:689-97. 1997
    ..with carcinoma at different sites (141 colon-rectum; 102 breast; 50 stomach; 48 kidney; 46 head and neck; 41 bladder; 47 other sites) submitted to surgery have been analyzed after histopathological staging and grading, by flow ..
  37. ncbi Effect of sulfosulfuron on the urine and urothelium of male rats
    L L Arnold
    Department of Pathology Microbiology and the Eppley Cancer Center, University of Nebraska Medical Center, Omaha 68198 3135, USA
    Toxicol Pathol 29:344-52. 2001
    ..Urinary bladder tumors were found in 2 females in the 5000 ppm group, both in the presence of calculi...
  38. pmc Immunomodulation in the treatment of multiple sclerosis and amyotrophic lateral sclerosis: a model for autoimmune disorders
    K Alonso
    Institute for Advanced Studies in Medicine, Atlanta, Georgia, USA
    J Natl Med Assoc 87:561-8. 1995
    ..17 patients presented with visual problems, 12 had lower extremity weakness or paraperesis/paralysis, and 6 had bladder/bowel dysfunction...
  39. pmc Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo
    A Lecci
    Pharmacology Research Dept, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:708-14. 1995
    1. The topical application of bradykinin (BK) (0.05-5000 pmol/rat) onto the serosal surface of the urinary bladder in urethane-anaesthetized rats, evoked low amplitude tonic contractions (not exceeding 25 mmHg) or high amplitude (about ..
  40. pmc Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro
    K Persson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 107:178-84. 1992
    ..methyl ester (L-NAME), 10 and 20 mg kg-1, administered intra-arterially, decreased micturition volume and bladder capacity, and increased spontaneous bladder contractions. D-NAME (20 mg kg-1) had no effect...
  41. ncbi Bilateral diffuse uveal melanocytic proliferation in a woman with uterine leiomyoma: case report
    Y C Chen
    Department of Ophthalmology, Chang Gung Memorial Hospital, Fu-Shin Street, Kweishan, Taoyuan, Taiwan
    Chang Gung Med J 24:274-9. 2001
    ..It was reported to be associated with primary carcinomas of the lung, ovary, colon, gall bladder, esophagus, pancreas, uterus, and cervix...
  42. ncbi Quadriplegia after lumbar disc surgery. A case report
    J J Langmayr
    , Innsbruck, Austria
    Spine (Phila Pa 1976) 21:1932-5. 1996
    ..Therapy included arterial blood pressure control, low molecular dextran, dexamethasone, bladder catheterization, and physiotherapy...
  43. ncbi Neoadjuvant CMV chemotherapy plus radical cystectomy in locally advanced bladder cancer: the impact of pathologic response on long-term results
    V Scattoni
    Department of Urology, Scientific Institute Ospedale San Raffaele, Milan, Italy
    Tumori 82:463-9. 1996
    AIMS AND BACKGROUND: Neoadjuvant systemic chemotherapy in infiltrating transitional cell carcinoma of the bladder has proved to be effective and to provide a pathologic complete response in about 30% of patients...
  44. pmc Activation of the micturition reflex by NK2 receptor stimulation in the anaesthetized guinea-pig
    M Bushfield
    Department of Discovery Biology, Pfizer Central Research, Sandwich, Kent
    Br J Pharmacol 115:875-82. 1995
    1. The mechanisms underlying stimulation of bladder contractions and bronchoconstriction by the selective NK2 receptor agonist, [beta-Ala8]NKA(4-10), were examined in the anaesthetized guinea-pig. 2...
  45. pmc Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation
    S Meini
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:1123-31. 1994
    ..atropine (1 microM) and guanethidine (3 microM), electrical field stimulation (EFS) of the rat isolated urinary bladder for 30 s induced a frequency-dependent (1-30 Hz) nonadrenergic non-cholinergic (NANC) triphasic contraction ..
  46. ncbi Scoliosis Research Society. Multicenter spine fracture study
    S D Gertzbein
    Texas Back Institute, Houston
    Spine (Phila Pa 1976) 17:528-40. 1992
    ..fractures there was a weakly positive relationship between canal compromise and neurologic deficit, including bladder function; 5) surgical intervention led to a greater percentage of improved neurologic function than nonoperative ..
  47. pmc Differential effects of suramin on P2-purinoceptors mediating contraction of the guinea-pig vas deferens and urinary bladder
    S J Bailey
    Receptors and Cellular Regulation Research Group, School of Biological Sciences, University of Surrey, Guildford, Surrey
    Br J Pharmacol 112:219-25. 1994
    ..P2-purinoceptor antagonist, suramin, was investigated on contractions of the guinea-pig vas deferens and urinary bladder induced by adenosine 5'-triphosphate (ATP) and by the other naturally occurring nucleoside triphosphates. 2...
  48. ncbi Development of generic models for ambulatory vaginal surgery--a preliminary report
    P E Papa Petros
    Royal Perth Hospital, Western Australia
    Int Urogynecol J Pelvic Floor Dysfunct 9:19-27. 1998
    ..repair; the creation of artificial neoligaments; the prevention of urinary retention by avoiding tightness in the bladder neck area; local anesthetic infiltration; and buttressing vaginal tissue during wound healing...
  49. ncbi Intraoperative improvements of somatosensory evoked potentials: correlation to clinical outcome in surgery for cervical spondylitic myelopathy
    J A Bouchard
    Division of Orthopaedic Surgery, University of Ottawa, Ontario, Canada
    Spine (Phila Pa 1976) 21:589-94. 1996
    ..All patients had rapid recovery of motor strength, bladder control, and ambulatory capacity within days of surgery...
  50. ncbi Comparability issues within the ITACARE data base
    E Buiatti
    Tuscany Tumour Registry, Italy
    Tumori 83:25-32. 1997
    ..As regards disease definition, the most relevant problems arose for urinary bladder. Skin melanoma should also be considered with some caution, due to variability among registries in coding in situ ..
  51. ncbi Dose-dependent amplification by L-ascorbic acid of NaHCO3 promotion of rat urinary bladder carcinogenesis
    H Iwata
    First Department of Pathology, Osaka City University Medical School, Japan
    Toxicol Pathol 25:284-90. 1997
    The dose dependence of L-ascorbic acid (AsA) copromotion of urinary bladder carcinogenesis with continuous concomitant administration of NaHCO3 was investigated. In the first experiment, 83 male F344 rats were all given 0...
  52. ncbi Urinary schistosomiasis in Maiduguri, north east Nigeria
    K S Chugh
    Department of Medicine, University of Maiduguri Teaching Hospital, Nigeria
    Ann Trop Med Parasitol 80:593-9. 1986
    ..Serum creatinine was raised in one patient (2.2 mg dl-1), Urological abnormalities included calcification of the bladder in 36.4%, ureteric strictures and dilatations in 65.9%, hydronephrosis in 9...
  53. ncbi Villous adenomas of the urinary tract: report of two cases
    M T Sung
    Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Chang Gung Med J 23:291-5. 2000
    ..The histogenesis and malignant potential are uncertain. We report on 2 cases, 1 each in the urethra and bladder. The first is a 57-year-old male who complained of an acute attack of urinary retention...
  54. ncbi Rat urinary bladder hyperplasia induced by oral administration of carbonic anhydrase inhibitors
    S Molon Noblot
    Department of Safety Assessment, Merck Sharp and Dohme Chibret, Riom, France
    Toxicol Pathol 20:93-102. 1992
    ..Similar urinary bladder changes were seen with both compounds...
  55. ncbi [Fundamental and clinical studies on MIC breakpoint of SY5555 for Enterococcus faecalis in complicated urinary tract infections of moderate severity]
    Y Kumamoto
    Sapporo Medical University, School of Medicine
    Kansenshogaku Zasshi 68:639-53. 1994
    ..faecalis. 1. Experimental study In a study employing an experimental model of complicated bladder infections of moderate severity, it was judged that the MIC breakpoints of SY5555 administered at 150 mg x 3/day ..
  56. ncbi Chemotherapy in invasive carcinoma of the bladder. A review of phase II trials in Egypt
    N Gad-el-Mawla
    Medical Oncology Department, National Cancer Institute, Cairo, Egypt
    Acta Oncol 28:73-6. 1989
    Since 1976, a series of phase II studies with screening of various chemotherapeutic agents in invasive bladder cancer have been conducted at the National Cancer Institute, Cairo...
  57. pmc Evidence for the presence of both pre- and postjunctional P2-purinoceptor subtypes in human isolated urinary bladder
    S Palea
    Department of Pharmacology, Glaxo Research Laboratories, Verona, Italy
    Br J Pharmacol 114:35-40. 1995
    1. In order to characterize P2-purinoceptor(s) in human urinary bladder the contractile effects of ATP and its slowly-hydrolyzable analogues alpha, beta-methylene ATP (alpha, beta-MeATP) and beta, gamma-methylene ATP (beta, gamma-MeATP) ..
  58. ncbi Bladder cancer in women
    H G van der Poel
    University Hospital, Nijmegen, The Netherlands
    Int Urogynecol J Pelvic Floor Dysfunct 10:207-12. 1999
    b>Bladder cancer is seen mainly in men. The incidence in women is increasing, but is still approximately three to four times lower than in men...
  59. pmc Tachykinin NK1 receptor subtypes in the rat urinary bladder
    S Meini
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:739-46. 1994
    ..the aim of the study was to investigate the possible heterogeneity of tachykinin NK1 receptors in the rat urinary bladder. 2. The synthetic tachykinin receptor agonists, septide (pD2 7.87) and [Sar9]substance P (SP) sulphone (pD2 7...
  60. ncbi Structure and blood supply of intrinsic lymph nodes in the wall of the rabbit urinary bladder--studies with light microscopy, electron microscopy, and vascular corrosion casting
    F E Hossler
    Department of Anatomy and Cell Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Anat Rec 252:477-84. 1998
    The urinary bladder is especially subject to infection by virtue of its direct connection to the external urethral opening, and it is natural to anticipate the presence of a well-developed immunological mechanism to respond to this ..
  61. pmc Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis
    S K Butt
    Biomedical Sciences Division, King s College London, Chelsea
    Br J Pharmacol 114:612-7. 1995
    ..and second-messenger coupling-mechanisms, of bradykinin B1 receptors in an intact tissue, the rabbit urinary bladder; and to investigate the influence of inhibition of endogenous peptidases on kinin activities. 2...
  62. ncbi Diagnosis and management of bladder injury by trauma surgeons
    Chi Hsun Hsieh
    Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
    Am J Surg 184:143-7. 2002
    b>Bladder injuries constitute one of the most common urological injuries involving the lower urinary tract. The methods of diagnosis and management of bladder trauma have been well established and accepted...
  63. ncbi Evidence for a unique elastic sheath surrounding the vesicular arteries of the rabbit urinary bladder--studies of the microvasculature with microscopy and vascular corrosion casting
    F E Hossler
    Department of Anatomy and Cell Biology, J H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Anat Rec 252:472-6. 1998
    Because the urinary bladder stores and releases urine, its normal function includes filling and emptying, accompanied by distension and relaxation. It is known that chronic distension compromises blood flow...
  64. ncbi [Cystectomy for indications other than bladder cancer]
    S Hautmann
    Urologische Klinik und Poliklinik, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Urologe A 43:172-7. 2004
    A cystectomy for indications other than transitional cell cancer of the bladder or general bladder cancer is frequently performed in cooperation with other surgical specialties such as general surgery or gynecology...
  65. ncbi Development and regenerative ability of bladder in the transgenic epidermal growth factor receptor gene knockout mouse
    M J DiSandro
    Department of Urology, University of California San Francisco, USA
    J Urol 158:1058-65. 1997
    During embryogenesis we have previously shown that urothelium is essential for normal bladder growth and development...
  66. ncbi [Bladder, bowel and sexual dysfunction in patient with mulitple sclerosis]
    Adnan Burina
    Medicinski fakultet Univerziteta u Tuzli
    Med Arh 60:182-4. 2006
    b>Bladder, bowel and sexual dysfunction are not rare in multiple sclerosis (MS). The most frequent bladder disorders are in urgency, frequency as well as retention...
  67. doi Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer
    G Mowatt
    Health Services Research Unit, Institute of Applied Health Sciences, University of Aberdeen, UK
    Health Technol Assess 14:1-331, iii-iv. 2010
    ..of photodynamic diagnosis (PDD) compared with white light cystoscopy (WLC), and urine biomarkers [fluorescence in situ hybridisation (FISH), ImmunoCyt, NMP22] and cytology for the detection and follow-up of bladder cancer.
  68. ncbi Quality of life study in prostate cancer patients treated with three-dimensional conformal radiation therapy: comparing late bowel and bladder quality of life symptoms to that of the normal population
    A L Hanlon
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 49:51-9. 2001
    The goals of this study were twofold. First, differences were quantified for symptoms that impact bowel and bladder quality of life (QOL) in prostate cancer patients treated with three-dimensional conformal radiotherapy (3DCRT) alone to ..
  69. pmc Contractility of urinary bladder and vas deferens after sensory denervation by capsaicin treatment of newborn rats
    A U Ziganshin
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 114:166-70. 1995
    ..sensory neurotoxin, was given to newborn rats and at the age of 3 months the contractile activity of the urinary bladder detrusor muscle and vas deferens evoked by either electrical field stimulation (EFS) or exogenous adenosine 5'-..
  70. doi Smooth muscle neoplasms of the urinary bladder: a clinicopathologic study of 51 cases
    Thomas K Lee
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 34:502-9. 2010
    Smooth muscle neoplasms of the urinary bladder are relatively rare. We report the largest series to date examining the clinicopathologic features of leiomyomas and leiomyosarcomas of the bladder...
  71. ncbi Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury
    Baojun Gu
    Department of Surgery, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    J Urol 177:2381-5. 2007
    ..Tocris Cookson, Ellisville, Missouri) inhibit bladder activity during saline infusion into the bladder of cats with chronic spinal cord injury (saline infused, spinal ..
  72. ncbi The classification and identification of human somatic and parasympathetic nerve fibres including urinary bladder afferents and efferents is preserved following spinal cord injury
    G Schalow
    Electromyogr Clin Neurophysiol 49:263-86. 2009
    ..Upon retrograde bladder filling the urinary bladder stretch and tension receptor afferent activities were increased; on two occasions ..
  73. ncbi [Urinary BTA-TRAK in the follow-up of superficial transitional-cell bladder carcinoma]
    Jesus M Fernández Gómez
    Servicio de Urologia, Hospital Central de Asturias, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Espana
    Arch Esp Urol 55:41-9. 2002
    To determine the efficacy of urinary BTA-TRAK as a marker in monitoring superficial transitional cell carcinoma of the bladder and to compare urine cytology with urinary sediment testing.
  74. ncbi Neuroblastoma of the urinary bladder, preclinically detected by mass screening
    S Yokoyama
    Departments of Pediatric Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Pediatrics 103:e67. 1999
    ..An extremely rare tumor at the dome of the urinary bladder in a 7-month-old infant was detected by the mass screening.
  75. ncbi Effect on urinary bladder function and arterial blood pressure of the activation of putative purine receptors in brainstem areas
    I Rocha
    Department of Physiology, Royal Free and University College Medical School, London, UK
    Auton Neurosci 88:6-15. 2001
    The effect on bladder function and arterial blood pressure of adenosine-5'-triphosphate (ATP) and its synthetic analogue, alpha,beta-methylene ATP (alpha,beta-meATP) applied by microinjection to brainstem areas was assessed in the ..
  76. ncbi Surveillance of patients with bladder carcinoma using fluorescent in-situ hybridization on bladder washings
    Jonathan Bergman
    Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    BJU Int 101:26-9. 2008
    ..Downers Grove, IL, USA) fluorescent in-situ hybridization (FISH) assay to that of urinary cytology obtained from bladder irrigation during cystoscopic surveillance in patients with bladder carcinoma.
  77. pmc Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Hum Genet 78:464-79. 2006
    ..In this hospital-based case-control study with 696 white patients newly diagnosed with bladder cancer and 629 unaffected white controls, we applied a multigenic approach to examine the associations with ..
  78. ncbi Experience with 100 cases treated with botulinum-A toxin injections in the detrusor muscle for idiopathic overactive bladder syndrome refractory to anticholinergics
    D M Schmid
    Department of Urology, University Hospital Zurich, Frauenklinikstrasse 10, CH 8091 Zurich, Switzerland
    J Urol 176:177-85. 2006
    ..ongoing study we evaluated the efficacy and safety of botulinum-A toxin injections in the detrusor muscle to treat patients with idiopathic overactive bladder resistant to conventional treatment, such as anticholinergic drugs.
  79. doi 5-Fluorouracil incorporated into the tissue RNA of human and rat bladder carcinoma after administration of 1-(2-tetrahydrofuryl)-5-fluorouracil combined with uracil
    Shigehiro Tsujimoto
    Department of Urology, Takanohara Central Hospital, 3 3 Ukyo 1 chome, Nara, Nara, 634 8522, Japan
    Int J Clin Oncol 13:138-43. 2008
    ..This study was conducted to examine the TS inhibition rate (TS-IR) and the concentration of 5-FU incorporated in RNA per milligram of tissue treated with UFT (F-RNA)...
  80. ncbi Efficacy of sodium hyaluronate in the management of chemical and radiation cystitis
    M L Sommariva
    Department of Urology, G Fornaroli Hospital, Magenta, Milan, Italy
    Minerva Urol Nefrol 62:145-50. 2010
    ..agents by intravesical instillation for non-muscle invasive transitional cell carcinoma of the bladder or after radiotherapy for prostatic cancer is frequent and problematic, since it responds poorly and slowly to ..
  81. ncbi [Effects of anesthesia on postoperative micturition and urinary retention]
    J P Pertek
    Departement d Anesthesie Reanimation, CHU de Nancy Brabois, Vandoeuvre les Nancy
    Ann Fr Anesth Reanim 14:340-51. 1995
    ..Surgical trauma to the pelvic nerves or to the bladder, postoperative oedema around the bladder neck, and pain-induced reflex spasm of the external and internal ..
  82. pmc Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha
    Marcia R Saban
    College of Medicine, Department of Physiology, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Immunol 9:4. 2008
    Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood...
  83. doi Pelvic fracture-related injuries of the bladder neck and prostate: their nature, cause and management
    Anthony R Mundy
    Institute of Urology, London, UK
    BJU Int 105:1302-8. 2010
    To report our experience of bladder neck injuries, which are a well recognized but rare consequence of pelvic fracture-related trauma to the lower urinary tract, as we have been unable to find any reference in the English literature to ..
  84. ncbi Prognostic significance of thymidylate synthase activity in bladder carcinoma
    Y Mizutani
    Department of Urology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Cancer 92:510-8. 2001
    5-fluorouracil (5-FU) is an anticancer agent clinically used against various cancers including bladder carcinoma. 5-FU inhibits thymidylate synthase (TS) and blocks DNA synthesis...
  85. doi The significance of a positive bladder neck margin after radical prostatectomy: the American Joint Committee on Cancer Pathological Stage T4 designation is not warranted
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 183:151-7. 2010
    The American Joint Committee on Cancer currently designates invasion of the bladder neck as a pT4 lesion...
  86. ncbi Therapeutic receptor targets for lower urinary tract dysfunction
    Naoki Yoshimura
    Department of Urology, University of Pittsburgh School of Medicine, Suite 700 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Naunyn Schmiedebergs Arch Pharmacol 377:437-48. 2008
    ..to store and periodically release urine, are dependent on the activity of smooth and striated muscles in the bladder, urethra, and external urethral sphincter...
  87. ncbi Damage to the bladder neck alters autonomous activity and its sensitivity to cholinergic agonists
    Rik de Jongh
    Department of Urology, University Hospital Maastricht, Maastricht, The Netherlands
    BJU Int 100:919-29. 2007
    ..motor component of the motor/sensory system, which contributes to sensation during the filling phase of the micturition cycle, as a result of surgically induced bladder pathology, i.e. damage to the bladder neck and outlet obstruction.
  88. ncbi Survival rates after radical cystectomy according to tumor stage of bladder carcinoma at first presentation
    Matthias May
    Urology Clinic, Carl Thiem Hospital, Cottbus, University Teaching Hospital Charité zu Berlin, Thiemstrasse, Cottbus, Germany
    Urol Int 72:103-11. 2004
    The aim of this study was to establish to what extent the survival rates of muscle-invasive bladder carcinoma are influenced by the tumor stage at initial presentation.
  89. ncbi Prognostic factors for primary superficial transitional cell carcinoma of the bladder: a retrospective cohort study
    Tu bao Yang
    Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078, China
    Chin Med J (Engl) 119:1821-8. 2006
    Previous studies showed that the prognostic factors for superficial transitional cell carcinoma of the bladder varied with the findings of different cohorts...
  90. doi Urodynamic findings of the painful bladder syndrome/interstitial cystitis: a comparison with idiopathic overactive bladder
    Sung Han Kim
    Department of Urology, Seoul National University Hospital, Seoul National University of Medicine, Seoul, Korea
    J Urol 181:2550-4. 2009
    In this study we identify the characteristics of the urodynamic results in patients with painful bladder syndrome/interstitial cystitis and in those with idiopathic overactive bladder.
  91. ncbi Management of functional bladder neck obstruction in women: use of alpha-blockers and pediatric resectoscope for bladder neck incision
    A Kumar
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    J Urol 162:2061-5. 1999
    Functional bladder neck obstruction has been definitively diagnosed in the last few years due to detailed synchronous pressure flow, electromyography and video urodynamics...
  92. ncbi Prognostic significance of orotate phosphoribosyltransferase activity in bladder carcinoma
    Yoichi Mizutani
    Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cancer 100:723-31. 2004
    5-Fluorouracil (5-FU), an antitumor agent, is used clinically against a variety of malignancies, including bladder carcinoma...
  93. ncbi Is a positive bladder neck margin truly a T4 lesion in the prostate specific antigen era? Results from the SEARCH Database
    W Cooper Buschemeyer
    Department of Surgery Division of Urologic Surgery, Duke University School of Medicine and Urology Section, Surgical Service, Veterans Affairs Medical Center Durham, Durham, North Carolina 27710, USA
    J Urol 179:124-9; discussion 129. 2008
    Positive bladder neck margins after radical prostatectomy are currently designated as pT4 lesions. However, to our knowledge the prognostic significance of a positive bladder neck margin in the prostate specific antigen era is unknown...
  94. ncbi Expanded PTFE bladder neck slings for incontinence in children: the long-term outcome
    P Godbole
    Department of Paediatric Urology, Sheffield Children s NHS Trust, Sheffield, UK
    BJU Int 93:139-41. 2004
    To assess the long-term outcome of circumferential expanded PTFE (Gore-tex, WL Gore Associates, Scotland) bladder neck slings for achieving urethral continence in children with a neuropathic bladder.
  95. ncbi Comparison of telomerase activity and matrix metalloproteinase-9 in voided urine and bladder wash samples as a useful diagnostic tool for bladder cancer
    Sanaa Eissa
    Oncology Diagnostic Unit, Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Eur Urol 44:687-94. 2003
    This study was undertaken to evaluate the diagnostic efficacy of telomerase in urine, and bladder wash and also the matrix metalloproteinase-9 (MMP-9) in urine, compared with voided urine cytology (VUC) and bladder wash cytology (BWC) ..
  96. doi Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management
    Gladell P Paner
    Department of Pathology, Section of Urology, The University of Chicago Hospitals, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Adv Anat Pathol 18:79-89. 2011
    b>Bladder urothelial carcinoma is typically a disease of older individuals and rarely occurs below the age of 40 years...
  97. ncbi Adenoviral receptor expression of normal bladder and transitional cell carcinoma of the bladder
    Maurizio Buscarini
    Department of Urology, USC School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, Calif, USA
    Urol Int 78:160-6. 2007
    ..The purpose of the present study was to determine the extent of expression and localization of the known Ad receptor proteins (CAR, alpha(v)beta3, and alpha(v)beta5) in normal and cancerous human bladders...
  98. ncbi The initial results in muscle-invading bladder cancer of RTOG 95-06: phase I/II trial of transurethral surgery plus radiation therapy with concurrent cisplatin and 5-fluorouracil followed by selective bladder preservation or cystectomy depending on the in
    D S Kaufman
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Oncologist 5:471-6. 2000
    ..surgery plus concomitant cisplatin, 5-fluorouracil (5-FU), and radiation therapy in conjunction with selective bladder preservation in patients with muscle-invading bladder cancer. Patients and Methods...
  99. ncbi [Recommendations for the urodynamic examination in the investigation of non-neurological female urinary incontinence]
    Jean Francois Hermieu
    Clinique Urologique, CHU Bichat 46 Rue Henri Huchard, 75018 Paris
    Prog Urol 17:1264-84. 2007
    ..Before any form of surgery for pure stress urinary incontinence, evaluation of bladder emptying by determination of maximum flow rate and residual urine is recommended...
  100. ncbi Effects of hyperthermia on the rat bladder: a pre-clinical study on thermometry and functional damage after treatment
    J Haveman
    Department of Radiotherapy, Academic Medical Centre, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Int J Hyperthermia 19:45-57. 2003
    The rat bladder was heated using a microwave applicator which was equipped with a system of circulating deionized water. The applicator was operated at 434 MHz and was placed at the ventral side with the rats in supine position...
  101. ncbi Diagnostic value of voided urine and bladder barbotage cytology in detecting transitional cell carcinoma of the urinary tract
    B R Konety
    Department of Urology, University of Pittsburgh Medical Center, and Veterans Affairs Medical Center, Pittsburgh, PA 15213, USA
    Urol Int 62:26-30. 1999
    ..with the use of urine cytology for the screening and diagnosis of transitional cell carcinoma (TCC) of the bladder and upper urinary tracts at our institution between January 1987 and December 1995...

Research Grants112 found, 100 shown here

  1. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..The acute phase of cystitis includes inflammation and bladder overactivity resulting from disruption of the urothelial cell (UC) permeability barrier and sensitization of ..
  2. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..Similar treatments today with live BCG help prevent recurrence of bladder cancer...
  3. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bladder augmentations using gastrointestinal tisue are frequently performed in children with complex urogenital anomalies...
  4. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..Broad Challenge is to develop enabling technologies for the prevention and treatment of diseases affecting the bladder. The Proof of Concept that we are testing is that intravesical instillation of small interference RNA (siRNA) ..
  5. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Overactive bladder incorporates to a variety of lower urinary tract symptoms (LUTS) including urinary frequency, urge incontinence, nocturia and pelvic pain...
  6. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ..There are two bladder associated niches for UPEC during acute UTI: the bladder tissue and the luminal space/urine...
  7. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..totals of diagnosed cases through 2005 include approximately 2,800 lung, 2,000 prostate, 700 colorectal, 500 bladder, 300-400 each for stomach, pancreas, and kidney cancers, 300 head and neck, and 1,100 for other sites combined...
  8. Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia after SCI
    Kenneth J Gustafson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Objectives and Research Aims: Neurogenic bladder resulting from disorders such as spinal cord injury (SCI) can have a devastating impact on patients and their families, resulting in a high cost to ..
  9. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic painful bladder syndrome that affects the lives of approximately one million people in the United States...
  10. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..Each year more than 5.8 million patients are diagnosed with cancers of colon, rectum, cervix, endometrium, bladder, stomach, head and neck, lung, esophagus, pancreas, osteosarcoma, ovary, and testis, for which first-line therapy ..
  11. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bladder cancer represents a major public health burden. The cost per bladder cancer patient from diagnosis to death is the highest among all cancers ($96,000 to $187, 000 per patient in the US)...
  12. Interrelationships among nutrients involved in one-carbon metabolism in Banglades
    MEGAN NINA HALL; Fiscal Year: 2011
    ..As is a class I carcinogen known to cause cancers of the skin, bladder, and lung, as well as ischemic heart disease and neurologic impairments...
  13. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..to understanding mechanisms of nociception and devising rational approaches to treat conditions such as painful bladder syndrome/interstitial cystitis...
  14. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..NRP2 Lacz+/- mice show strong expression of NRP2 in bladder smooth muscle cells (BSMC). SEMA3F alters the morphology of these SMC, a new SEMA3F function...
  15. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    ..strategies for the regeneration of a variety of tissues including skin, corneal epithelium, cartilage, bone and bladder. Tissue regeneration would represent an important advancement in the treatment of salivary gland hypofunction ..
  16. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..A common complication of SCI is the development of a neurogenic bladder, which involves lower urinary tract dysfunction and a loss of voluntary control...
  17. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..The results will potentially benefit tens of millions of patients suffering from severely damaged vascular or nervous systems, heart, kidneys, liver, skeleton, bladder, or other organs.
  18. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..Renal clearances are not useful in these conditions because of mixture of urine in the bladder whereas independent catheterization of ureters (split renal function) lead to pyelonephritis...
  19. Developing a murine model for arsenic-induced skin neoplasm
    Mohammad Athar; Fiscal Year: 2010
    ..incidence of cancers of the lung, skin (both basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs)), bladder, liver, prostate as well as in other organs...
  20. PREVENTION OF QUINONE TOXICITY AND MUTAGENICITY
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..All were born normal, however, NQO1-/- mice exhibited painful bladder syndrome (PBS)...
  21. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..Such an approach may be extrapolated to other motor deficits (i.e., locomotion, bladder control, and sexual function) that occur secondary to impaired motoneuron function in a variety of neurological ..
  22. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ..of using microsatellite analysis of urine sediment in the early detection of transitional cell carcinoma of the bladder and as the primary validation laboratory of the Validation Study of the use of SELDI-TOF-MS to identify protein ..
  23. Development of Novel LANCL2-based Anti-diabetic Compounds
    JOSEP BASSAGANYA; Fiscal Year: 2013
    ..effects suc as cardiovascular complications, hepatotoxicity, adipose tissue accumulation, and fluid retention, bladder tumors...
  24. Host Defense Mechanisms in Polyaromatic Hydrogen Carcinogenesis
    Craig A Elmets; Fiscal Year: 2013
    ..They cause lung cancer and have been implicated in cancers of the head and neck, bladder and breast...
  25. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
    ..Patients with inflammatory bowel disease often experience increased sensory responsiveness in the urinary bladder reflecting neurogenic bladder overactivity...
  26. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    ..we will establish that in USM Ca2+ sparks act as a contractile mechanism, rather than a relaxing mechanism as in bladder and vascular smooth muscle, by controlling global [Ca2+]I, membrane potential, and urethra tone using RyR2 R176Q ..
  27. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2013
    ..This project explores the role of integrins and integrin-signaling pathways within the epithelium lining the bladder - the urothelium - where almost nothing is known of their function...
  28. Exposure and biological response biomarkers of cigarette smoke
    IAN ALEXANDER BLAIR; Fiscal Year: 2010
    ..There is substantial evidence that PAHs are causative agents in lung, skin, and bladder cancer...
  29. Mechanisms of arsenic-induced chromosomal instability and carcinogenesis
    Wei Dai; Fiscal Year: 2013
    ..to arsenic is highly associated with the occurrence of several types of malignancies, including skin, lung and bladder cancer...
  30. Optically-Guided Bladder Biopsy Using Polarized Elastic Scattering Spectroscopy
    FREDERICK GEORGE BARGOOT; Fiscal Year: 2010
    ..proposal is for the development of a fiber-optic based system for the detection and surveillance of early stage bladder cancer. The technology is based on Polarized Elastic Scattering Spectroscopy (PESS)...
  31. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    ..who have urinary catheters to help with urination, a bacterium called Proteus mirabilis often infects the bladder and causes stones to form there...
  32. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..of the nervous system, manifested by attacks of muscle weakness and loss of coordination, visual disturbances, bladder dysfunction and cognitive impairment...
  33. Gene Networks in Neural Crest-derived Innervation of the Lower Urinary Tract
    E MICHELLE MICHELLE SOUTHARD SMITH; Fiscal Year: 2010
    ..Anatomical and immunohistochemical studies of bladder innervation have identified neural components and some of the neurotransmitter subtypes that are present in late ..
  34. Extracellular Replication of Listeria in Vivo
    Christopher H Contag; Fiscal Year: 2010
    ..Replication in the gall bladder could be the source of asymptomatic carriage of this pathogen in humans and a potential reservoir leading to food ..
  35. A novel axis regulates adipocyte plasticity
    Sean Hartig; Fiscal Year: 2013
    ..sensitivity and fat storage efficiency in T2DM with serious, negative side effects including edema, bone loss, bladder cancer, and heart failure...
  36. Intra-operative confocal imaging to guide Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..Future applications may include mapping of cancers to guide surgery in oral, head-and-neck, breast, bladder, liver and other tissues. BCCs and SCCs occur with among the highest rates of incidence, with an estimated 1...
  37. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Painful bladder syndrome/Interstitial cystitis (PBS/IC) is a chronic painful condition of the urinary bladder in which there are no proven etiologies and no effective treatments that are able to ..
  38. Bisphenol A: Urine flow disorder and prostate pathology
    FREDERICK S contact VOM SAAL; Fiscal Year: 2010
    ..These males die due to retention of urine in the bladder associated with extensive periurethral gland hyperplasia;all of these mice also have HGPIN in a majority of ..
  39. MEPRINS-METALLOPROTEINASES OF THE KIDNEY AND INTESTINE
    Judith S Bond; Fiscal Year: 2010
    ..Mice of different meprin genotypes will be infected with uropathic bacteria in the bladder, and the susceptibility to bladder and kidney infections will be determined...
  40. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2009
    ..exposure to arylamines used in the manufacturing of industrial dyes was the first known cause of human bladder cancer...
  41. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Painful bladder syndrome/interstitial cystitis (PBS/IC) is an indolent bladder disorder that has continued to be a debilitating disease with few truly effective treatment options...
  42. Arrayed Lateral Flow Biosensor for Rapid Molecular Identification of UTI-Related
    Anjal C Sharma; Fiscal Year: 2012
    ..A urinary tract infection (UTI) is an infection that can happen anywhere along the urinary tract (urethra, bladder, kidneys, and ureters)...
  43. Morphogenesis of mammalian gut endoderm
    Anna Katerina Hadjantonakis; Fiscal Year: 2012
    ..cell types of many internal organs, including the thyroid, thymus, lung, stomach, liver, pancreas, intestine and bladder. A rigorous understanding of normal gut endoderm morphogenesis, including knowledge of the origin, commitment, ..
  44. ROLES AND REGULATION OF P53
    Carol Prives; Fiscal Year: 2013
    ..has progressed, our research has become more translational and relevant to human disease, now focusing on breast, bladder and lymphoma tumor genesis...
  45. PSMA-based Cancer Imaging Agents
    Martin G Pomper; Fiscal Year: 2013
    ..PCa tends to undergo definitive treatment despite the side effects of bowel, bladder and/or sexual dysfunction...
  46. Research and Mentoring on Energetic Factors and Cancer: Established Investigator
    Leslie Bernstein; Fiscal Year: 2013
    ..index, waist-hip ratio, and waist-height ratio) and risk of breast, endometrial, ovarian, lung, colon, pancreas, bladder, rectal and thyroid cancer, non-Hodgkin's lymphoma and melanoma. Dr...
  47. Transcriptional mechanisms of lower urinary tract development
    Gerald Mingin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Congenital abnormalities of the upper (kidney) and lower (ureter, bladder, urethra and external genitalia) urinary tracts are diagnosed at a rate of 1 in 500 prenatal ultrasounds...
  48. Mechanism of Type I and II Caused Diabetic Bladder Dysfunction
    Firouz Daneshgari; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our long term goals are to uncover the mechanisms underlying diabetic bladder dysfunction (DBD), one of the most common and incapacitating complications of the diabetes mellitus (DM), and develop ..
  49. Directed differentiation of embryonic stem cells for urologic applications
    James A Bassuk; Fiscal Year: 2010
    ..embryonic stem cells (ESCs) in regenerative medicine applications such as tissue engineered repair of the urinary bladder and its associated tract...
  50. Pharmacology of Intravesical Antisense Based Therapy for Over Active Bladder
    Naoki Yoshimura; Fiscal Year: 2013
    DESCRIPTION: Because of current, limited options for treating overactive bladder (OAB) or lower urinary tract symptoms (LUTS), there is a great demand for the development of new treatment strategy...
  51. Nutrients involved 1-carbon metabolism and the methylation of arsenic and DNA
    MEGAN NINA HALL; Fiscal Year: 2013
    ..As is a class I carcinogen known to cause cancers of the skin, bladder, and lung, as well as ischemic heart disease and neurologic impairments...
  52. Clinical center for the study of neuroprotection from PD
    Joseph Jankovic; Fiscal Year: 2013
    ..Another participant has bladder cancer and we are coordinating his PD related care with his nephrologist/oncologist, another has newly diagnosed ..
  53. Wireless Implantable Monitor for Improved Neuromodulation
    Margot S Damaser; Fiscal Year: 2012
    ..In addition, these bladder complications of SCI can lead to autonomic dysreflexia, renal failure, and stroke...
  54. Mast cell actions in chronic progressive versus relapsing remitting EAE
    JULIANNE K HATFIELD; Fiscal Year: 2013
    ..as they pass through demyelinated regions of the brain or spinal cord leads to visual disturbances, bowel and bladder incontinence, sensory and motor disturbances and lack of coordination...
  55. Health benefits of vigorous exercise in middle-aged versus older men and women
    Paul T Williams; Fiscal Year: 2010
    ..rates of diabetes, hypercholesterolemia, hypertension, angina, cardiovascular disease, stroke, arthritis, gall bladder disease, vision (cataracts, glaucoma, macular degeneration), heart rhythm abnormalities, kidney stones, and ..
  56. Synchrotron imaging of crystalline biofilms in urinary catheters
    Aaron I Packman; Fiscal Year: 2010
    ..These deposits form stones and encrustations in the bladder and kidneys, as well as encrustations on inserted devices such as catheters and ureteral stents...
  57. Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention
    Emily White; Fiscal Year: 2013
    ..expected by 2011), and the range of cancers that can be studied (prostate, breast, lung, colorectal, melanoma, bladder, blood/lymph) attract young investigators to work with her...
  58. Mapping serotonin receptors in lower urinary tract innervation
    E Michelle Southard-Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Recurrent pain of the bladder, pelvis or urogenital floor is a defining feature of chronic pelvic pain syndromes including Interstitial Cystitis and Chronic Prostatitis...
  59. Novel IL-15 Superagonist Therapy for Bladder Cancer
    Hing C Wong; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Non-Muscle Invasive Bladder cancer (NMIBC), the fifth most common cancer in the United States and the costliest to treat per patient of all cancers, tends to recur, requiring repeated intervention ..
  60. Mechanotransduction in the Ciliary Muscle
    Andrew D Pucker; Fiscal Year: 2013
    ..Kirk McHugh, a cell and molecular biologist who is an expert in the study of smooth muscle in bladder and obstructive (stretch) nephropathy in the mouse;Dr...
  61. Clinical Outcomes for Siblings of Children with Vesico-Ureteral Reflux
    CALEB PENNELL NELSON; Fiscal Year: 2013
    ..VUR is the retrograde flow of urine from the bladder into the ureter and kidney, and is associated with urinary tract infection (UTI) and renal injury...
  62. EphB4 as Novel Target for Breast Cancer Imaging
    PETER STEPHEN CONTI; Fiscal Year: 2012
    ..addition to breast cancer, EphB4 is also significantly over-expressed in melanoma, prostate cancer, colon cancer, bladder cancer, lung cancer, mesothelioma, uterine cancer, and osteosarcoma...
  63. Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action
    Daniel Shoskes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interstitial cystitis (IC), also referred to as Painful Bladder Syndrome (PBS) is a condition with significant impact on quality of life...
  64. Estrogen Regulation in BPH and the Lower Urinary Tract
    WILLIAM ALLEN RICKE; Fiscal Year: 2013
    ..changing hormone levels, especially testosterone (T) and estradiol-17b (E2), are underlying causes of BPH and bladder outlet obstruction (BOO)...
  65. Autonomic Rare Diseases Clinical Research Consortium
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Autonomic disorders cause loss of regulation of the heart, blood vessels, stomach, bowel and bladder. Affected patients frequently have palpitations or lose consciousness, and some have a rapidly fatal course...
  66. Enhancing dendritic cell migration to drive potent anti-tumor immune responses
    Kristen Batich; Fiscal Year: 2013
    ..brain tumors in adults account for more deaths than Hodgkin's disease, melanoma, and cancers of the bladder or kidney...
  67. Early-life arsenic exposure and adult mortality in Region II, Chile
    Allan H Smith; Fiscal Year: 2013
    ..These increases were found for bladder cancer (standardized mortality ratio [SMR]=21.3;95% confidence interval [CI], 11.6 to 35...
  68. Paracrine Regulation of BPH Pathogenesis
    Simon W Hayward; Fiscal Year: 2013
    ..constriction with a consequent slowing of urinary flow rates and an inability to properly empty the urinary bladder. In the Western world BPH is not a life threatening condition...
  69. A Follow-up of Children Enrolled in the Management of Myelomeningocele Study
    ELIZABETH ANN THOM; Fiscal Year: 2013
    ..All children will undergo video urodynamics, renal/bladder ultrasound and urine culture to evaluate urologic status...
  70. Steroid hormones and SFRP1 in the age-related incidence of BPH and BOO
    Paul C Marker; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS), including bladder voiding symptoms, are a common problem in aging men. Voiding symptoms occur in many cases due to bladder outlet obstruction (BOO)...
  71. Analysis of the role of the SWI/SNF complex in tumor suppression
    Charles Roberts; Fiscal Year: 2013
    ..at high frequency in a variety of human cancers including those of ovary, breast, kidney, lung, pancreas, uterus, bladder, stomach, colon, liver [and skin]...
  72. A novel device for improving sepsis outcomes through hemodynamic optimization
    Brett D Mensh; Fiscal Year: 2013
    ..of changes in cardiac output (from the relative amplitude of cardiovascular pressure waves transmitting into the bladder) and intra-abdominal pressure, both of which can be critical pieces of information for clinicians making ..
  73. Molecular Pathogenesis of the Hamartoma Syndromes
    David J Kwiatkowski; Fiscal Year: 2013
    ..genetic syndromes, each of these genes is also involved in the development of typical adult malignancies: TSC1 - bladder carcinoma;TSC2 - PEComas pancreatic neuroendocrine tumors, and bladder cancer;PTEN - many adult cancers, ..
  74. Delineating the importance of intracellular tissue occupation by Uropathogenic E.
    DREW JOEL SCHWARTZ; Fiscal Year: 2013
    ..coli (UPEC). The pathogenesis of UTI is complex with UPEC capable of colonizing multiple niches within the bladder and the kidneys...
  75. Roles for Serotonin in Autonomic Innervation of the Lower Urinary Tract
    KAREN ELAINE RITTER; Fiscal Year: 2013
    ..Mutant mice expressing a hypersensitive form of the 5-HT3A receptor gene, Htr3a vs/vs, display a hypertrophic bladder phenotype in conjunction with urinary incontinence...
  76. The cold-sensing circuit of Drosophila larvae
    ASHLEY JAMES VONNER; Fiscal Year: 2013
    ..deafness, vestibular difficulties, neurological disorders, cardiac hypertrophy, gastroesophageal reflux disease, bladder diseases, several cancers, and chronic obstructive pulmonary disease...
  77. Development of Mental Health Treatment for Obstetric Fistula Patients
    Melissa H Watt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstetric fistula is a hole between the bladder or rectum and the vagina, which develops when obstructed labor is not relieved by cesarean section and results in uncontrollable leaking of urine and/..
  78. Purinergic Regulation of Bladder Interstitial Cells of Cajal
    Weiqun Yu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary incontinence, overactive bladder (OAB) and neurogenic bladder often arise from inappropriate bladder smooth muscle (BSM) motility and the underlying mechanisms are poorly understood...
  79. Neurogenic bladder dysfunctions in neurological disorders
    Anna P Malykhina; Fiscal Year: 2013
    ..Neurogenic bladder dysfunctions observed in patients with neurological disorders usually result from damage to the peripheral and/or ..
  80. nGUDMAP ??? Ontology, Database and Website Core
    RICHARD ALAN BALDOCK; Fiscal Year: 2013
    ..Urologic chronic pelvic pain syndromes (UCPPS) are a collection of syndromes that include both painful bladder syndrome (PBS) and chronic pelvic pain syndrome (CPPS)...
  81. The ILK/PINCH/Parvin complex in renal tubulogenesis
    Roy Zent; Fiscal Year: 2013
    ..and gives rise to the collecting system of the mature kidney from the collecting ducts (CD) to the trigone of the bladder. The renal papilla and CDs develop by undergoing iterative branching morphogenesis, a complex process that is, at ..
  82. Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
    Karl J Kreder; Fiscal Year: 2013
    ..g. bladder, urethra, vagina, prostate and/or pelvic floor muscle dysfunction), we hypothesize that many patients have ..
  83. Ca2+ Sparks and Urinary Bladder Smooth Muscle Excitability
    Mark T Nelson; Fiscal Year: 2013
    ..The co-occurrence of urinary bladder and erectile dysfunction suggests the existence of mechanistic commonalities...
  84. Formation of the Enteric Nervous System
    Chen Ming Fan; Fiscal Year: 2013
    ..e. the enteric neurons, are located within the gastrointestinal (GI) tract, pancreas, and gall bladder. They control the movement, secretion, and absorption of the digestive system...
  85. Microbiome-Based Risk Assessment: Reciprocal Effects of Arsenic on Environmental
    Stephanie Bachas-Daunert; Fiscal Year: 2013
    ..Chronic exposure leads to arsenicosis, which includes melanosis, keratosis, as well as lung, bladder, kidney, and skin cancer...
  86. Molecular and spatial mapping of bladder nociceptors during development and matur
    Adam Wallace; Fiscal Year: 2013
    ..primary structural and molecular features of a major population of nociceptor neurons that innervate the urinary bladder of the mouse...
  87. Validation in Transgenic Animal Models of Clinical Correlates of IC/PBS
    Yi Luo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic inflammatory condition of the urinary bladder characterized by symptoms of chronic pelvic pain and urinary frequency and urgency ..
  88. Common Mechanisms of Stem Cell Regulation in Bladder Cancer and Regeneration
    Kunyoo Shin; Fiscal Year: 2013
    ..Recent findings have identified basal epithelial cells that express the Sonic hedgehog (Shh) ligand in urinary bladder as urothelial stem cells, capable of regenerating the urothelium following injury in vivo and of forming bladder-..
  89. The Role of Basement Membrane Biomechanics in Cancer Cell Invasion
    Aron Parekh; Fiscal Year: 2013
    ..In Specific Aim 1, the chemical, physical, and mechanical properties of the ECM scaffold urinary bladder matrix-BM (UBM-BM) will be characterized to establish this material as a physiologically relevant in vitro ECM ..
  90. Molecular and Functional Mechanisms of Purinergic Relaxation in Detrusor Muscle
    Sang Don Koh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Overactive bladder is a highly prevalent condition, affecting approximately 33 million adults in the United States. Symptoms include frequency, urgency, urge incontinence, or nocturia...
  91. Mechanism of the Usher in Assembly and Secretion of Pili
    David G Thanassi; Fiscal Year: 2013
    ..P and type 1 pili are critical virulence factors, allowing binding and colonization of the kidney and bladder, respectively...
  92. Generating molecular markers that selectively label urothelial sub-populations
    CATHY LEE MENDELSOHN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The urinary outflow tract, including the renal pelvis, ureters, bladder and upper urethra, is lined by a specialized stratified epithelium called the urothelium, composed of a basal layer, an ..
  93. Elastic Fiber Homeostasis in the Vaginal Wall
    Hiromi Yanagisawa; Fiscal Year: 2013
    ..of the most prevalent pelvic floor disorders is pelvic organ prolapse, a condition in which the pelvic organs (bladder, vagina, cervix and uterus) herniate through the vaginal opening...
  94. ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTION
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..by uropathogenic Escherichia coli, which employ an adhesive fiber termed the type 1 pilus to bind and invade bladder epithelial cells...
  95. Bladder Nociception: function/central projection of Sympathetic Afferent Pathway
    William C DeGroat; Fiscal Year: 2013
    DESCRIPTION: Painful bladder syndrome/interstitial cystitis (PBS/IC) is a disease with unknown etiology, which presents clinically as urinary urgency, frequency, and bladder associated pain...
  96. Bladder Voiding via Pudendal Nerve Block
    KENNETH GUSTAFSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bladder Voiding via Pudendal Nerve Block - Project Summary/Abstract Objectives and Research Aims: Bladder dysfunction after neurological injury or disorders such as spinal cord injury (SCI), ..
  97. Smooth muscle plasticity: A COBRE
    Kenton M Sanders; Fiscal Year: 2013
    ..Seungil Ro;Project 5: Stretch-dependent potassium channel regulation in overactive bladder to be led by Dr. Sang Don Koh...
  98. ATG16L1 AND MOLECULAR REGULATION OF BACTERIAL PERSISTENCE
    Indira U Mysorekar; Fiscal Year: 2013
    ..coli (UPEC) persists as quiescent reservoirs in membrane-bound compartments within the bladder wall and causes frequent and recurrent urinary tract infections (UTIs)...
  99. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    The urinary bladder is often the site of subacute or chronic inflammation, in the absence of infection, as in interstitial cystitis (IC), a painful bladder disorder occurring mostly in women...
  100. Regeneration, Repair and Remodeling of the Lower Urinary Tract
    GEORGE JOSEPH CHRIST; Fiscal Year: 2013
    ..The scientific project specifically targets the estimated 35 million Americans that suffer from bladder disease, most of which are chronic conditions (i.e...
  101. Rapid release paclitaxel nanoparticles for bladder cancer intravestical therapy
    Ze Lu; Fiscal Year: 2009
    b>Bladder cancer is the fourth most common cancer in the United States. In 2007, about 67,160 new cases of bladder cancer will be diagnosed and 13,750 patients will die of these diseases...