urinary tract

Summary

Top Publications

  1. ncbi The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society
    Paul Abrams
    Neurourol Urodyn 21:167-78. 2002
  2. pmc Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract
    M Chelsea Lane
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 104:16669-74. 2007
  3. ncbi Interstitial cell of Cajal-like cells in the upper urinary tract
    R J Lang
    Department of Physiology, Faculty of Medicine and Health Sciences, Monash University, Clayton, 3168, Victoria, Australia
    J Cell Mol Med 9:543-56. 2005
  4. ncbi Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering
    Shantaram Bharadwaj
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27101, USA
    Tissue Eng Part A 17:2123-32. 2011
  5. pmc Human alpha defensin 5 expression in the human kidney and urinary tract
    John David Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 7:e31712. 2012
  6. ncbi Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract
    John D Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Kidney Int 80:174-80. 2011
  7. pmc Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract
    Indira U Mysorekar
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:14170-5. 2006
  8. pmc Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization
    Kelly J Wright
    Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Infect Immun 73:7657-68. 2005
  9. pmc Genetic and developmental basis for urinary tract obstruction
    Feng Chen
    Renal Division, Department of Internal Medicine, Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Pediatr Nephrol 24:1621-32. 2009
  10. ncbi Phosphodiesterase type 5 expression in human and rat lower urinary tract tissues and the effect of tadalafil on prostate gland oxygenation in spontaneously hypertensive rats
    Annamaria Morelli
    Department of Clinical Physiopathology, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 8:2746-60. 2011

Detail Information

Publications315 found, 100 shown here

  1. ncbi The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society
    Paul Abrams
    Neurourol Urodyn 21:167-78. 2002
  2. pmc Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract
    M Chelsea Lane
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 104:16669-74. 2007
    Uropathogenic Escherichia coli (UPEC) cause most uncomplicated urinary tract infections (UTIs) in humans...
  3. ncbi Interstitial cell of Cajal-like cells in the upper urinary tract
    R J Lang
    Department of Physiology, Faculty of Medicine and Health Sciences, Monash University, Clayton, 3168, Victoria, Australia
    J Cell Mol Med 9:543-56. 2005
    Autorhythmicity in the upper urinary tract (UUT) has long been considered to arise in specialized atypical smooth muscle cells (SMC) predominately situated in the most proximal regions of the pyeloureteric system...
  4. ncbi Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering
    Shantaram Bharadwaj
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27101, USA
    Tissue Eng Part A 17:2123-32. 2011
    The goals of this study were to characterize urine-derived stem cells obtained from the upper urinary tract (uUSC), induce these cells to differentiate into urothelial and smooth muscle cells, and determine whether they could serve as a ..
  5. pmc Human alpha defensin 5 expression in the human kidney and urinary tract
    John David Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 7:e31712. 2012
    The mechanisms that maintain sterility in the urinary tract are incompletely understood. Recent studies have implicated the importance of antimicrobial peptides (AMP) in protecting the urinary tract from infection...
  6. ncbi Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract
    John D Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Kidney Int 80:174-80. 2011
    Although the urinary tract is constantly challenged by microbial invasion, it remains free from colonization...
  7. pmc Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract
    Indira U Mysorekar
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:14170-5. 2006
    Recurrent urinary tract infections (rUTIs) are a source of considerable morbidity in women. The infecting bacteria in both rUTIs and a de novo acute infection have been thought to originate from an extraurinary location...
  8. pmc Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization
    Kelly J Wright
    Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Infect Immun 73:7657-68. 2005
    In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, ..
  9. pmc Genetic and developmental basis for urinary tract obstruction
    Feng Chen
    Renal Division, Department of Internal Medicine, Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Pediatr Nephrol 24:1621-32. 2009
    b>Urinary tract obstruction results in obstructive nephropathy and uropathy. It is the most frequent cause of renal failure in infants and children...
  10. ncbi Phosphodiesterase type 5 expression in human and rat lower urinary tract tissues and the effect of tadalafil on prostate gland oxygenation in spontaneously hypertensive rats
    Annamaria Morelli
    Department of Clinical Physiopathology, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 8:2746-60. 2011
    ....
  11. pmc Fstl1 antagonizes BMP signaling and regulates ureter development
    Jingyue Xu
    MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China
    PLoS ONE 7:e32554. 2012
    Bone morphogenetic protein (BMP) signaling pathway plays important roles in urinary tract development although the detailed regulation of its activity in this process remains unclear...
  12. ncbi Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: a potential animal model for interstitial cystitis
    Yi Hao Lin
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan
    BJU Int 102:1724-30. 2008
    ..To examine bladder function in a newly developed experimental autoimmune cystitis (EAC) model in female SWXJ strain mice, as a potential animal model for interstitial cystitis (IC)...
  13. ncbi Urinary tract infections caused by Pseudomonas aeruginosa: a minireview
    Rahul Mittal
    Division of Infectious Diseases, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Infect Public Health 2:101-11. 2009
    b>Urinary tract infections (UTIs) are a serious health problem affecting millions of people each year. Infections of the urinary tract are the second most common type of infection in the body...
  14. ncbi Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling
    Andrea Brenner-Anantharam
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 134:1967-75. 2007
    b>Urinary tract morphogenesis requires the sub-division of the ureteric bud (UB) into the intra-renal collecting system and ureter, two tissues with unique structural and functional properties...
  15. pmc Anorectal malformations caused by defects in sonic hedgehog signaling
    R Mo
    Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 159:765-74. 2001
    ....
  16. ncbi Antimicrobial peptides, innate immunity, and the normally sterile urinary tract
    Michael Zasloff
    Division of Surgical Immunology, Department of Surgery, Georgetown University School of Medicine, Washington, DC, USA
    J Am Soc Nephrol 18:2810-6. 2007
    ..Epithelia lining the urinary tract prevent adhesion of bacteria by release of Tamm-Horsfall protein, lactoferrin, lipocalin, and constitutive and ..
  17. ncbi Genetics of congenital anomalies of the kidney and urinary tract
    Renfang Song
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Nephrol 26:353-64. 2011
    Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 1 in 500 births and are a major cause of morbidity in children...
  18. ncbi Muscarinic receptor subtypes in the lower urinary tract
    Daniel Giglio
    Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Pharmacology 83:259-69. 2009
    ..review describes signalling mechanisms, expression and functional effects of muscarinic receptors in the lower urinary tract. Their roles in physiological and pathophysiological conditions, as well as clinical implications of the ..
  19. ncbi Vanilloid receptor 1 expression in the rat urinary tract
    A Avelino
    Institute of Histology and Embryology, Faculty of Medicine of Oporto, IBMC of University of Oporto, Porto, Portugal
    Neuroscience 109:787-98. 2002
    ..the distribution, morphology and the neurochemical content of nerve fibres expressing this receptor in the rat urinary tract. Immunolabelling was performed against the VR1 and the positive fibres were examined by light and electron ..
  20. ncbi Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs
    Betsy Foxman
    Department of Epidemiology, Center for Molecular and Clinical Epidemiology of Infectious Diseases, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109 2029, USA
    Infect Dis Clin North Am 17:227-41. 2003
    ..The benefits of successfully preventing UTI are substantial...
  21. ncbi Innate and adaptive immune responses in the urinary tract
    J Song
    Department of Molecular Genetics and Microbiology, Duke University Medical Centre, Durham, NC 27710, USA
    Eur J Clin Invest 38:21-8. 2008
    As new and intriguing details of how uropathogens initiate infections and persist within the urinary tract have emerged, so has important information regarding how the immune system functions within the urinary tract...
  22. pmc Enterococcal aggregation substance and binding substance are not major contributors to urinary tract colonization by Enterococcus faecalis in a mouse model of ascending unobstructed urinary tract infection
    James R Johnson
    Mucosal and Vaccine Research Center, VA Medical Center and Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Infect Immun 72:2445-8. 2004
    ..These data suggest that AS and EBS do not contribute to upper or lower urinary tract colonization by E...
  23. pmc Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations
    Rajshekhar Chatterjee
    Department of Internal Medicine Renal Division, Washington University School of Medicine, Box 8126, 660 S Euclid Ave, St Louis, MO 63110, USA
    Hum Genet 131:1725-38. 2012
    ..neurotrophic factor (GDNF)-RET receptor tyrosine kinase and SPRY1, a RET repressor, is essential for early urinary tract development...
  24. ncbi Renal outcome in patients with congenital anomalies of the kidney and urinary tract
    Simone Sanna-Cherchi
    Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Kidney Int 76:528-33. 2009
    Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are a major cause of morbidity in children...
  25. pmc Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract
    Stefania Gimelli
    Biologia Generale e Genetica Medica, Universita di Pavia, Pavia, Italy Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland
    Hum Mutat 31:1352-9. 2010
    Congenital anomalies of the kidney and the urinary tract (CAKUT) represent a major source of morbidity and mortality in children...
  26. pmc Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli
    Kimberly A Kline
    Department of Molecular Microbiology, Center for Women s Infectious Disease Research, Washington University School of Medicine, St Louis, Missouri, USA
    Infect Immun 80:4186-94. 2012
    b>Urinary tract infection (UTI) is most often caused by uropathogenic Escherichia coli (UPEC)...
  27. ncbi Rates of urinary tract injury from gynecologic surgery and the role of intraoperative cystoscopy
    D T Gilmour
    Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada
    Obstet Gynecol 107:1366-72. 2006
    To estimate the rates of urinary tract injury after benign gynecologic surgery. To explore the role of routine intraoperative cystoscopy at benign gynecologic surgery.
  28. ncbi Urinary tract infection
    Lindsay E Nicolle
    Department of Internal Medicine, Health Sciences Centre, University of Manitoba, Room GG443, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada
    Crit Care Clin 29:699-715. 2013
    The urinary tract is a common source for life-threatening infections. Most patients with sepsis or septic shock from a urinary source have complicated urinary tract infection...
  29. ncbi Complicated urinary tract infections
    Durwood E Neal
    Division of Urology, Department of Surgery, University of Missouri, Columbia, MO 65212, USA
    Urol Clin North Am 35:13-22; v. 2008
    A complicated urinary tract infection is that which occurs in a patient with an anatomically abnormal urinary tract or significant medical or surgical comorbidities...
  30. ncbi Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract
    Farah K Bahrani-Mougeot
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Microbiol 45:1079-93. 2002
    Escherichia coli is the leading cause of urinary tract infections (UTIs). Despite the association of numerous bacterial factors with uropathogenic E. coli (UPEC), few such factors have been proved to be required for UTI in animal models...
  31. ncbi Polymerase chain reaction-based identification of Propionibacterium acnes types isolated from the male urinary tract: evaluation of adolescents, normal adults and men with prostatic pathology
    Beverley A Shannon
    Tissugen Pty Ltd, Perth, Western Australia
    BJU Int 98:388-92. 2006
    To assess whether colonization of the male urinary tract with Propionibacterium acnes, in particular types IB and II (which are associated with inflammation in radical prostatectomy specimens and might be involved in the development of ..
  32. ncbi Maintaining a sterile urinary tract: the role of antimicrobial peptides
    Ased S M Ali
    Newcastle University, Newcastle upon Tyne, United Kingdom
    J Urol 182:21-8. 2009
    The normally sterile urinary tract is constantly challenged by microbial invasion leading to a high prevalence of isolated, recurrent and catheter associated urinary tract infection...
  33. pmc Cre/lox recombination in the lower urinary tract
    Yinqiu Wang
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Genesis 47:409-13. 2009
    Tbx18 is a T-Box transcription factor that has specific expression and indispensible function in the lower urinary tract. Here, we report the generation and characterization of a bacterial artificial chromosome (BAC) transgene expressing ..
  34. pmc Covert operations of uropathogenic Escherichia coli within the urinary tract
    Jean M Bower
    Pathology Department, Division of Cell Biology and Immunology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, Utah 84132 2501, USA
    Traffic 6:18-31. 2005
    ..Among these are strains of uropathogenic Escherichia coli (UPEC), the primary causative agents of urinary tract infections (UTIs)...
  35. ncbi Urinary tract infection due to Achromobacter xylosoxidans: report of 9 cases
    Daniel Tena
    Section of Microbiology, University Hospital of Guadalajara, Guadalajara, Spain
    Scand J Infect Dis 40:84-7. 2008
    b>Urinary tract infection (UTI) due to Achromobacter xylosoxidans is rare. The aims were to know the frequency and clinical characteristics of this infection in our area...
  36. ncbi Hirschsprung disease and congenital anomalies of the kidney and urinary tract (CAKUT): a novel syndromic association
    Alessio Pini Prato
    Department of Pediatric Surgery, Giannina Gaslini Institute, Genoa, Italy
    Medicine (Baltimore) 88:83-90. 2009
    Congenital anomalies of the kidney and urinary tract (CAKUT) can be associated with Hirschsprung disease (HSCR)...
  37. pmc Mutations in DSTYK and dominant urinary tract malformations
    S Sanna-Cherchi
    Division of Nephrology, Columbia University, New York, NY 10032, USA
    N Engl J Med 369:621-9. 2013
    Congenital abnormalities of the kidney and the urinary tract are the most common cause of pediatric kidney failure. These disorders are highly heterogeneous, and the etiologic factors are poorly understood.
  38. ncbi CHD1L: a new candidate gene for congenital anomalies of the kidneys and urinary tract (CAKUT)
    Antje Brockschmidt
    Institute of Human Genetics, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Nephrol Dial Transplant 27:2355-64. 2012
    Recently, we identified a microduplication in chromosomal band 1q21.1 encompassing the CHD1L/ALC1 gene encoding a chromatin-remodelling enzyme in congenital anomalies of the kidneys and urinary tract (CAKUT) patient.
  39. pmc Abolition of biofilm formation in urinary tract Escherichia coli and Klebsiella isolates by metal interference through competition for fur
    Viktoria Hancock
    Microbial Adhesion Group, DTU Food, Bldg 301, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Appl Environ Microbiol 76:3836-41. 2010
    ..In the urinary tract, free iron is strictly limited but is critical for bacterial growth...
  40. ncbi Sacral neuromodulation for neurogenic lower urinary tract dysfunction: systematic review and meta-analysis
    Thomas M Kessler
    Department of Urology, University of Bern, Bern, Switzerland
    Eur Urol 58:865-74. 2010
    Treatment of neurogenic lower urinary tract dysfunction (LUTD) is a challenge, because conventional therapies often fail...
  41. pmc Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT)
    Matthias T F Wolf
    Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
    Pediatr Nephrol 24:55-60. 2009
    ..Mutations in HNF1B cause a phenotype similar to FJHN/GCKD but also congenital anomalies of the kidney and the urinary tract (CAKUT). Moreover, we recently detected UMOD mutations in two patients with CAKUT...
  42. pmc Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development
    Dagan Jenkins
    Nephro Urology, and Clinical and Molecular Genetics Units, UCL Institute of Child Health, UK
    J Anat 211:620-9. 2007
    ..signalling has a functional role in morphogenesis and differentiation at multiple sites within the forming urinary tract, and urinary tract malformations have been reported in humans with mutations that disrupt SHH signalling...
  43. ncbi Toll-like receptors recognize uropathogenic Escherichia coli and trigger inflammation in the urinary tract
    Hans Joachim Anders
    Nephrol Dial Transplant 20:1529-32. 2005
  44. ncbi Emerging antibiotic resistance in urinary tract pathogens
    Kalpana Gupta
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington School of Medicine, BB1221, Box 356523, Seattle, WA 98195, USA
    Infect Dis Clin North Am 17:243-59. 2003
    ..In the meantime, ongoing surveillance of resistance trends and enhanced understanding of the determinants of resistance are crucial for optimal management of UTIs...
  45. ncbi Outcome of isolated antenatal hydronephrosis: a prospective cohort study
    Graziela M Coelho
    Pediatric Nephrourology Unit, Department of Pediatrics, Hospital das Clinicas, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Pediatr Nephrol 22:1727-34. 2007
    ..The events of interest were: presence of uropathy, need for surgical intervention, RPD resolution, urinary tract infection (UTI), and hypertension. RPD was classified as mild (5-9.9 mm), moderate (10-14...
  46. ncbi Mapping candidate regions and genes for congenital anomalies of the kidneys and urinary tract (CAKUT) by array-based comparative genomic hybridization
    Stefanie Weber
    Division of Pediatric Nephrology, University Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 26:136-43. 2011
    Congenital anomalies of the kidneys and urinary tract (CAKUT) are frequently associated with malformations of other organs.
  47. ncbi HNF1B alterations associated with congenital anomalies of the kidney and urinary tract
    Makiko Nakayama
    Department of Nephrology, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Nephrol 25:1073-9. 2010
    ..factor 1beta (HNF1beta) abnormalities have been recognized to cause congenital anomalies of the kidney and urinary tract (CAKUT), predominantly affecting bilateral renal malformations...
  48. pmc Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli
    Rebecca E Watts
    Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    Infect Immun 80:333-44. 2012
    The molecular mechanisms that define asymptomatic bacteriuria (ABU) Escherichia coli colonization of the human urinary tract remain to be properly elucidated. Here, we utilize ABU E...
  49. ncbi Maternal risk factors for congenital urinary anomalies: results of a population-based case-control study
    Margarett Shnorhavorian
    Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
    Urology 78:1156-61. 2011
    Epidemiologic data addressing maternal risk factors for congenital urinary tract anomalies (CUTA) are limited, with conflicting results for preexisting diabetes mellitus, gestational diabetes, and tobacco and alcohol use...
  50. ncbi Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT
    Yoichi Miyazaki
    Departments of Pediatrics and Medicine, Vanderbilt University Medical Center Nashville, TN, USA
    Pediatr Int 45:598-604. 2003
    ..the Wolffian duct is the first ontogenic misstep that leads to many congenital anomalies of the kidney and urinary tract (CAKUT)...
  51. pmc A comparison of urinary tract pathology and morbidity in adult populations from endemic and non-endemic zones for urinary schistosomiasis on Unguja Island, Zanzibar
    Beatrice Lyons
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    BMC Infect Dis 9:189. 2009
    ..The aim of this study was to assess the burden of urinary tract pathology and morbidity due to schistosomiasis in Zanzibar and identify reliable clinical predictors of ..
  52. pmc Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women
    Thomas R Hawn
    Department of Medicine, University of Washington, Seattle, Washington, USA
    PLoS ONE 4:e8300. 2009
    ..We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria...
  53. ncbi Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse
    Inga J Murawski
    Department of Pediatrics, Montreal Children s Hospital, McGill University, Quebec, Canada
    Am J Physiol Renal Physiol 293:F1736-45. 2007
    Vesico-ureteric reflux (VUR) is a urinary tract abnormality that affects roughly one-third of patients with renal-coloboma syndrome, an autosomal dominant condition caused by a mutation in PAX2...
  54. ncbi The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
    Milan Chromek
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nat Med 12:636-41. 2006
    The urinary tract functions in close proximity to the outside environment, yet must remain free of microbial colonization to avoid disease...
  55. ncbi The destruction of the lower urinary tract by ketamine abuse: a new syndrome?
    Peggy Sau Kwan Chu
    Division of Urology, Department of Surgery, Tuen Mun Hospital, Hong Kong, China
    BJU Int 102:1616-22. 2008
    ..young abusers of street-ketamine (regular recreational abusers of street-ketamine, for its hallucinogenic effects) in Hong Kong, presenting with significant lower urinary tract symptoms (LUTS) but with no evidence of bacterial infection.
  56. pmc Increased prevalence of renal and urinary tract anomalies in children with congenital hypothyroidism
    Juhi Kumar
    Division of Pediatric Nephrology, The Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    J Pediatr 154:263-6. 2009
    ..We investigated the prevalence of congenital renal and urologic anomalies in children with congenital hypothyroidism to determine whether further renal and urologic investigations would be of benefit...
  57. ncbi Differentiation of epithelial cells in the urinary tract
    Rok Romih
    Medical Faculty, Institute of Cell Biology, Ljubljana, Slovenia
    Cell Tissue Res 320:259-68. 2005
    Uroplakins, cytokeratins and the apical plasma membrane were studied in the epithelia of mouse urinary tract. In the simple epithelium covering the inner medulla of the renal pelvis, no uroplakins or cytokeratin 20 were detected and ..
  58. pmc Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro
    K Persson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 107:178-84. 1992
    ..to investigate how blockade of the L-arginine/nitric oxide (NO) pathway influences the function of the lower urinary tract in vivo, as studied by cystometry in conscious rats and in vitro, in isolated muscle preparations from the rat ..
  59. ncbi Pathogenic potential of environmental Klebsiella pneumoniae isolates
    Carsten Struve
    Department of Gastrointestinal and Parasitic Infections, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    Environ Microbiol 6:584-90. 2004
    ..K. pneumoniae infections can occur at nearly any body site; however, urinary tract infections and infections of the respiratory tract predominate...
  60. pmc Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073
    Andrew T Anfora
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 1300 University Ave, Room 481 MSC, Madison, WI 53706, USA
    Infect Immun 75:5298-304. 2007
    ..mutant of uropathogenic Escherichia coli strain CFT073 has a hypercolonization phenotype in a murine model of urinary tract infection (UTI) due to increased virulence gene expression by an unknown mechanism (B. J. Haugen et al...
  61. pmc Physiopathology and etiology of stone formation in the kidney and the urinary tract
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Ms 5055, Indianapolis, IN 46220, USA
    Pediatr Nephrol 25:831-41. 2010
    ....
  62. ncbi Association of lower urinary tract symptoms and chronic ischaemia of the lower urinary tract in elderly women and men: assessment using colour Doppler ultrasonography
    Germar Michael Pinggera
    Department of Urology, Medical University of Innsbruck, Austria
    BJU Int 102:470-4. 2008
    ..TRCDUS) whether perfusion of the bladder and prostate is reduced in elderly patients with lower urinary tract symptoms (LUTS), common in later life, as experimental data suggest that chronic ischaemia has a key role in ..
  63. ncbi High urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissues
    David A Spector
    Division of Renal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 292:F467-74. 2007
    Although the mammalian urinary tract is generally held to be solely a transit and storage vehicle for urine made by the kidney, in vivo data suggest reabsorption of urea and other urine constituents across urinary tract epithelia...
  64. ncbi Biofilms and catheter-associated urinary tract infections
    Sanjay Saint
    Ann Arbor VA Medical Center, Ann Arbor, MI, USA
    Infect Dis Clin North Am 17:411-32. 2003
    ..Future research should focus on additional methods for preventing this common infection...
  65. ncbi Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis
    Lindsay E Nicolle
    Departments of Internal Medicine and Medical Microbiology, Health Sciences Centre, University of Manitoba, Winnipeg, MB, Canada
    Urol Clin North Am 35:1-12, v. 2008
    Acute uncomplicated urinary tract infection and acute pyelonephritis are very common infections affecting many women throughout their lives...
  66. ncbi C-Kit receptor (CD117) in the porcine urinary tract
    Roman Metzger
    Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany
    Pediatr Surg Int 24:67-76. 2008
    ..been shown in the genitourinary tract, but systematic studies on the distribution and density of IC within the urinary tract are still lacking...
  67. ncbi Maternal residence near municipal waste incinerators and the risk of urinary tract birth defects
    Sylvaine Cordier
    Inserm U625, Universite Rennes I, Campus de Beaulieu, Rennes Cedex, France
    Occup Environ Med 67:493-9. 2010
    ..In a previous ecological study we found an association between the risk of urinary tract birth defects and residence in the vicinity of municipal solid waste incinerators (MSWIs)...
  68. ncbi Increased prevalence of renal and urinary tract anomalies in children with Down syndrome
    Juan C Kupferman
    Divisions of Pediatric Nephrology and Hypertension, Maimonides Infants and Children s Hospital, Brooklyn, New York 11219, USA
    Pediatrics 124:e615-21. 2009
    The goal was to investigate the prevalence of renal and urinary tract anomalies (RUTAs) in a Down syndrome (DS) population.
  69. ncbi Pharmacologic perspective on the physiology of the lower urinary tract
    Karl Erik Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Urology 60:13-20; discussion 20-1. 2002
    ..However, a selective action on the lower urinary tract may be difficult to obtain...
  70. pmc Drug Insight: biological effects of botulinum toxin A in the lower urinary tract
    Michael B Chancellor
    Department of Urology, William Beaumont Hospital in Royal Oak, MI 8073, USA
    Nat Clin Pract Urol 5:319-28. 2008
    ..feedback loops might not only help to explain the mechanism of BTX-A in relieving symptoms of overactive bladder, but also suggest a potential role for BTX-A in the relief of hyperalgesia associated with lower urinary tract disorders.
  71. ncbi Novel genetic aspects of congenital anomalies of kidney and urinary tract
    Stefanie Weber
    Pediatrics II, University Children s Hospital Essen, Essen, Germany
    Curr Opin Pediatr 24:212-8. 2012
    Congenital anomalies of the kidney and urinary tract (CAKUT) are among the most frequent organ malformations. They are a relevant cause of chronic renal failure in children...
  72. ncbi Functional analysis of BMP4 mutations identified in pediatric CAKUT patients
    Mansoureh Tabatabaeifar
    Pediatric Nephrology, University of Heidelberg Children s Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 24:2361-8. 2009
    Human congenital anomalies of the kidney and urinary tract (CAKUT) represent the major causes of chronic renal failure (CRF) in children...
  73. ncbi The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract
    Bjorn Wullt
    Division of Clinical Immunology, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Int J Antimicrob Agents 19:522-38. 2002
  74. ncbi Pelvic floor training for lower urinary tract dysfunction in MS
    Doreen McClurg
    Glasgow Caledonian University, Glasgow, UK
    Nurs Times 105:45-7. 2009
    The aim of this study was to determine if pelvic floor muscle training (PFMT) improves lower urinary tract function in people with multiple sclerosis (MS)...
  75. pmc Transcriptome of Proteus mirabilis in the murine urinary tract: virulence and nitrogen assimilation gene expression
    Melanie M Pearson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Infect Immun 79:2619-31. 2011
    The enteric bacterium Proteus mirabilis is a common cause of complicated urinary tract infections. In this study, microarrays were used to analyze P. mirabilis gene expression in vivo from experimentally infected mice...
  76. ncbi Lithiasis in cystic kidney disease and malformations of the urinary tract
    G Gambaro
    Divisione di Nefrologia, Dipartimento di Scienze Biomediche e Chirurgiche, Universita di Verona, Ospedale Maggiore, P le Stefani 1, 37126, Verona, Italy
    Urol Res 34:102-7. 2006
    ..A proper metabolic evaluation should be conducted to diagnose specific, treatable metabolic disorders, thereby reducing the frequency of recurrent stone disease in these conditions as well...
  77. ncbi Intermediate-term outcomes of robot-assisted laparoscopic nephroureterectomy in upper urinary tract urothelial carcinoma
    Sey Kiat Lim
    Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, South Korea
    Clin Genitourin Cancer 11:515-21. 2013
    ..The purpose of this study was to evaluate the intermediate-term oncological outcomes after (RAL-NU) for UUT-UC...
  78. ncbi Predicting the need for radiologic imaging in adults with febrile urinary tract infection
    C van Nieuwkoop
    Departments of Infectious Diseases, Leiden University Medical Center, Diaconessenhuis Hospital, Leiden, The Netherlands
    Clin Infect Dis 51:1266-72. 2010
    Radiologic evaluation of adults with febrile urinary tract infection (UTI) is frequently performed to exclude urological disorders. This study aims to develop a clinical rule predicting need for radiologic imaging.
  79. ncbi Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system
    Kevin T Bush
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, and Urological Diseases Research Center, Department of Urology, Children s Hospital, Boston, MA 02115, USA
    Dev Biol 298:571-84. 2006
    ..a lumen lined by cells expressing uroplakin (a protein exclusively expressed in the epithelium of the lower urinary tract)...
  80. ncbi [Gestational diabetes and urinary tract malformations: a hospital case-control study]
    Arnaud Fotso Kamdem
    Service de Chirurgie Pédiatrique et Orthopédique, Hopital Saint Jacques, Besancon, France
    Prog Urol 15:53-8. 2005
    b>Urinary tract malformations represent the leading cause of renal failure in children. Gestational diabetes plays a controversial role in the development of urinary tract malformations...
  81. pmc Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection
    Drew J Schwartz
    Department of Pediatrics, Molecular Genetics, and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA
    Infect Immun 79:4250-9. 2011
    b>Urinary tract infections (UTIs) have complex dynamics, with uropathogenic Escherichia coli (UPEC), the major causative agent, capable of colonization from the urethra to the kidneys in both extracellular and intracellular niches while ..
  82. ncbi Alterations in the formation of cyclic nucleotides and prostaglandins in the lower urinary tract of the diabetic rabbit
    F H Mumtaz
    Department of Urology, Royal Free and University Medical School University College London and The Royal Free Hampstead NHS Trust, UK
    Urol Res 27:470-5. 1999
    ..to forskolin and sodium nitroprusside, respectively, was significantly reduced in the DM tissues of the lower urinary tract compared to the control...
  83. ncbi Urinary tract anomalies and dysfunctional voiding: a spectrum dictated by the influence of amniotic pressure upon fetal urodynamics
    F C Tanyel
    Department of Pediatric Surgery, Hacettepe University, Institute of Child Health, Ankara, Turkey
    Med Hypotheses 54:140-5. 2000
    The etiologic basis of urinary tract anomalies and dysfunctional voiding largely remain unknown...
  84. pmc Extracellular ATP and P2Y receptor activation induce a proinflammatory host response in the human urinary tract
    Susanne Säve
    School of Natural Sciences, Linnaeus University, Kalmar, Sweden
    Infect Immun 78:3609-15. 2010
    ..The present study suggests that enhanced ATP release and P2Y receptor activation during urinary tract infection may represent a novel, non-TLR4-mediated mechanism for production of proinflammatory IL-8 in human ..
  85. ncbi Ultrasonographic screening of newborns for congenital anomalies of the kidney and the urinary tracts
    Yilmaz Tabel
    Department of Pediatric Nephrology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
    Urol J 7:161-7. 2010
    ..To search for the efficiency of scanning the newborns with routine urinary system ultrasonography...
  86. ncbi Proteus mirabilis isolates of different origins do not show correlation with virulence attributes and can colonize the urinary tract of mice
    Vanessa Sosa
    Laboratorio de Microbiologia, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    Microbiology 152:2149-57. 2006
    ..has been described as an aetiological agent in a wide range of infections, playing an important role in urinary tract infections (UTIs). In this study, a collection of P...
  87. ncbi Challenges facing renal transplantation in pediatric patients with lower urinary tract dysfunction
    Paul Riley
    Academic Foundation Year Two, London South Thames Deanery, London, United Kingdom
    Transplantation 89:1299-1307. 2010
    ..The commonest cause is a congenital abnormality of the kidneys and urinary tract, often associated with lower urinary tract dysfunction (LUTD)...
  88. ncbi [Recurrent urinary tract infections]
    Carlos Pigrau-Serrallach
    Servicio de Enfermedades Infecciosas, Hospital Universitari Vall d Hebron, Universidad Autonoma, Barcelona, Espana
    Enferm Infecc Microbiol Clin 23:28-39. 2005
    Recurrent urinary tract infections (RUTI) are a frequent clinical problem in sexually active young women, pregnant or postmenopausal women and in patients with underlying urological abnormalities...
  89. ncbi Diuresis renography for differentiation of upper urinary tract dilatation from obstruction: F+20 and F-15 methods
    Rahim Taghavi
    Department of Urology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
    Urol J 4:36-40. 2007
    ..was to evaluate diuresis renography with an intravenous injection of furosemide 20 minutes after administering the radiopharmaceutical (F+20 protocol) or 15 minutes before (F-15 protocol) in patients with upper urinary tract dilatation.
  90. ncbi Strategies to treat children with end-stage renal dysfunction and severe lower urinary tract anomalies for receiving a kidney transplant
    Wlliam C Nahas
    Division of Urology, Renal Transplant Unit, University of Sao Paulo, Sao Paulo, Brazil
    Pediatr Transplant 13:524-35. 2009
    ..Patients with severe lower urinary tract abnormalities and ESRD may receive a kidney transplant with comparable success.
  91. ncbi Urinary tract biomaterials
    Darren T Beiko
    Department of Urology, Queen s University, Kingston, University of Western Ontario, London, Ontario, Canada
    J Urol 171:2438-44. 2004
    As a result of endourological advances, biomaterials have become increasingly used within the urinary tract. This review article provides an update on the current status of urinary tract biomaterials, discussing issues of ..
  92. ncbi Ultrasound monitoring of structural urinary tract disease in Schistosoma haematobium infection
    Charles H King
    Division of Geographic Medicine, Case Western Reserve University SOM, Cleveland, Ohio 44106, USA
    Mem Inst Oswaldo Cruz 97:149-52. 2002
    ..Results indicate that urinary tract abnormalities are common (18% overall prevalence) in S...
  93. ncbi Urinary tract infection: one lingering effect of childhood kidney diseases--review of the literature
    Prayong Vachvanichsanong
    Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    J Nephrol 20:21-8. 2007
    b>Urinary tract infection (UTI) is a possible warning sign of the presence of anomalies of the urinary tract...
  94. ncbi Unilateral multicystic dysplastic kidney: a meta-analysis of observational studies on the incidence, associated urinary tract malformations and the contralateral kidney
    Michiel F Schreuder
    Department of Pediatric Nephrology, Radboud University Nijmegen Medical Centre, Amsterdam, The Netherlands
    Nephrol Dial Transplant 24:1810-8. 2009
    ..multicystic dysplastic kidney (MCDK) patients, but show variable results as to the incidence of associated urinary tract abnormalities...
  95. ncbi A molecular and genetic view of human renal and urinary tract malformations
    A S Woolf
    Nephro Urology Unit, Institute of Child Health, University College London, England, United Kingdom
    Kidney Int 58:500-12. 2000
    Malformations of the kidney and lower urinary tract are common causes of chronic renal failure in infants and young children, but little is known about the molecular pathogenesis of these disorders...
  96. pmc Alfuzosin, a selective alpha 1-adrenoceptor antagonist in the lower urinary tract
    F Lefevre-Borg
    Department of Biology, Synthelabo Recherche, Bagneux, France
    Br J Pharmacol 109:1282-9. 1993
    ..5. Alfuzosin is a potent selective alpha1-adrenoceptor antagonist in tissues of the lower urinary tract including the human prostate...
  97. pmc Plasticity in reflex pathways to the lower urinary tract following spinal cord injury
    William C de Groat
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical School, Pittsburgh, PA 15261, USA
    Exp Neurol 235:123-32. 2012
    The lower urinary tract has two main functions, storage and periodic expulsion of urine, that are regulated by a complex neural control system in the brain and lumbosacral spinal cord...
  98. ncbi Adult care of children from pediatric urology
    Christopher R J Woodhouse
    Centre for Urology, University College London Hospitals and the Centre for Nephrology, University College London Royal Free Campus, London, United Kingdom
    J Urol 187:1164-71. 2012
    ..We review some abnormalities of the kidneys, progressive renal failure and disorders of bladder function from which general conclusions can be drawn...
  99. ncbi The role of magnetic resonance imaging in pediatric urology
    Andrew J Kirsch
    Departments of Pediatric Urology, Emory University School of Medicine, Atlanta, Georgia 30342, USA
    Curr Opin Urol 16:283-90. 2006
    ..The aim of this review is to familiarize the reader with the current applications and basic techniques utilizing magnetic resonance imaging in pediatric uroradiology...
  100. ncbi MR urography in children: how we do it
    J Damien Grattan-Smith
    Department of Radiology, Children s Healthcare of Atlanta, 1001 Johnson Ferry Road, Atlanta, GA 30342, USA
    Pediatr Radiol 38:S3-17. 2008
    ..This paper provides an overview of the practical issues associated with obtaining high-quality scans as well as an introduction into the interpretation of MR urograms...
  101. ncbi Fungal infections of the urinary tract
    J D Sobel
    Department of Medicine, Detroit Medical Center, Wayne State University School of Medicine, Michigan, USA
    World J Urol 17:410-4. 1999
    Funguria, fungal urinary tract infections, are most commonly caused by Candida species but may also be caused by Cryptococcus neoformans, Aspergillus species, and the endemic mycoses...

Research Grants77

  1. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..lung infections, deep wound healing, the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic middle ear infections...
  2. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..to become an independent investigator in the broad field of DNA damage and repair as it pertains to the lower urinary tract. The Candidate and his co-mentors, Drs...
  3. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..non-viral nanosphere siRNA complexes that are intravesically instilled for treatment of diseases of the urinary tract. This past year, in collaboration with Drs. W...
  4. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Overactive bladder incorporates to a variety of lower urinary tract symptoms (LUTS) including urinary frequency, urge incontinence, nocturia and pelvic pain...
  5. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..Rationale: Patients with diabetes are at higher risk than the general population of developing cancer of the urinary tract, liver, pancreas, colon, endometrium and kidney...
  6. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Over 15 million women suffer from urinary tract infections (UTI) annually in the U.S., ~85% of which are caused by uropathogenic Escherichia coli (UPEC)...
  7. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..discharge, Incidence of nosocomial infections [late-onset bacteremia, pneumonia, necrotizing enterocolitis, urinary tract infection, and meningitis] and incidence of "NEC Scares", "neonatal sepsis syndrome" or "systemic inflammatory ..
  8. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..We have preliminary data demonstrating that stem cells increase the elastin content of lower urinary tract tissues, suggesting the feasibility of stem cell administration to facilitate recovery after delivery and ..
  9. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..In addition, A. baumannii biofilms have been implicated in cystic fibrosis, periodontitis and urinary tract infections, due to the bacteria's ability to colonize indwelling medical devices...
  10. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose a novel and competitive urinary tract silicone Foley catheter made from a proprietary polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via ..
  11. Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia after SCI
    Kenneth J Gustafson; Fiscal Year: 2012
    ..Neurogenic bladder frequently leads to other urologic complications, such as incontinence, urinary tract infection, renal damage and consequent renal dialysis or transplantation which can lead to recurrent and ..
  12. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..cells) allowing generation of a concentration-time profile for any amino/neoglycoside that mimics the human urinary tract profile...
  13. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..and Stenotrophomonas, which are prevalent in severe nosocomial infections, such as pneumonia, bacteremia and urinary tract infections...
  14. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..A common complication of SCI is the development of a neurogenic bladder, which involves lower urinary tract dysfunction and a loss of voluntary control...
  15. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..of axonal injury and allow me to design disease-specific molecular-based therapies to preserve lower urinary tract function...
  16. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..and a membrane-lytic toxin, hemolysin (Hly), are often co- expressed by Escherichia coli strains that cause urinary tract infections (UTIs), i.e., cystitis or pyelonephritis, or acute prostatitis...
  17. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..In pregnancy, GBS can cause urinary tract infections, chorioamnionitis, postpartum wound infection, pyelonephritis, sepsis, and rarely meningitis...
  18. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The urinary tract is a complicated epithelial-lined tube with an opening to the body surface, making it susceptible to infection by exogenous organisms...
  19. Effect of D-cycloserine on treatment of PTSD in youth
    Michael S Scheeringa; Fiscal Year: 2010
    ..D-cycloserine (DCS), an antibiotic used to treat tuberculosis and urinary tract infections, is a partial agonist at the glycine modulatory site of the N-methyl- D-aspartic acid (NMDA) ..
  20. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..resistance in Enterobacteriaceae bacteria (such as Escherichia coli and Klebsiella pneumoniae) that produce urinary tract and bloodstream infections in children, by analyzing clinical isolates from 4 children's hospitals across ..
  21. Tissue recovery in the pathophysiology of stress urinary incontinence
    Adonis K Hijaz; Fiscal Year: 2013
    ..between two interacting processes: 1)Injury- from child birth related trauma to the tissues of the lower urinary tract and pelvic floor and 2)Recovery- ability of the injured tissues to recover from birth trauma injury...
  22. Gene Networks in Neural Crest-derived Innervation of the Lower Urinary Tract
    E MICHELLE MICHELLE SOUTHARD SMITH; Fiscal Year: 2010
    ..Identifying trophic molecules and signaling mechanisms that control migration of NC into the lower urinary tract (LUT) and regulate the differentiation of these progenitors upon arrival is an essential prelude to ..
  23. Molecular and Cellular Regulation of Mammalian Renal Medulla Development
    Jing Yu; Fiscal Year: 2013
    ..a common condition occurs in approximately 1 in 100 people and a consequence of acute and chronic urinary tract obstructions and neurological deficits...
  24. Arrayed Lateral Flow Biosensor for Rapid Molecular Identification of UTI-Related
    Anjal C Sharma; Fiscal Year: 2012
    ..by applicant): The aim of this application is to develop a rapid, easy-to-use, and inexpensive test for urinary tract infection diagnosis using an ultrasensitive arrayed lateral flow nucleic acid biosensor (LFNAB) to identify ..
  25. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..Importantly, LL-37 is naturally produced in the urinary system, is significantly upregulated during urinary tract infection episodes, and appears to trigger profound bladder inflammation...
  26. Maternal genitourinary infections and adverse perinatal outcomes
    Abdullah Hel Baqui; Fiscal Year: 2013
    ..provided by applicant): Maternal genitourinary (GU) infections, particularly bacterial vaginosis (BV) and urinary tract infections (UTI) are common but inadequately quantified in low-middle income countries...
  27. Determinants of Telomere Length in Chronic SCI: A Pilot Study
    Eric Garshick; Fiscal Year: 2012
    ..in study spinal cord injury (lac of exercise, obesity, chronic or recurrent inflammation from skin ulcers, and urinary tract infections) as well as in persons with cardiovascular and pulmonary diseases...
  28. Transcriptional mechanisms of lower urinary tract development
    Gerald Mingin; Fiscal Year: 2013
    ..I have subsequently demonstrated that the Six1-Eya1 transcriptional complex is also required for lower urinary tract formation...
  29. Cholesterol and Prostate Health
    Michael R Freeman; Fiscal Year: 2013
    ..Research into the mechanisms of lower urinary tract dysfunction in males may open new opportunities for therapy, however devising hypotheses involving signal ..
  30. Pharmacology of Intravesical Antisense Based Therapy for Over Active Bladder
    Naoki Yoshimura; Fiscal Year: 2013
    DESCRIPTION: Because of current, limited options for treating overactive bladder (OAB) or lower urinary tract symptoms (LUTS), there is a great demand for the development of new treatment strategy...
  31. BIOGENESIS AND INHIBITION OF BIOFILM-ASSOCIATED BACTERIAL AMYLOID
    Scott J Hultgren; Fiscal Year: 2013
    ..These include urinary tract infections (UTIs), chronic skin infections, otitis media and cystic fibrosis lung infections...
  32. Synchrotron imaging of crystalline biofilms in urinary catheters
    Aaron I Packman; Fiscal Year: 2010
    ..Proteus is an extremely common pathogen in urinary tract infections, and is particularly problematic in patients subject to long-term urinary catheterization. P...
  33. Innate immune suppression following experimental injury
    KRISTIN C GREATHOUSE; Fiscal Year: 2012
    ..we will evaluate the ability of GM-CSF to reduce the severity of experimentally induced nosocomial infection (urinary tract infection) following surgical injury...
  34. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
    ..coli (ExPEC) strains, including urinary tract infections (UTIs), newborn meningitis (NBM), abdominal sepsis, and septicemia, result in significant morbidity,..
  35. Mapping serotonin receptors in lower urinary tract innervation
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..The cell bodies of pain- sensing neurons, nociceptors, that innervate the lower urinary tract reside in the dorsal root ganglia amidst many other sensory neurons and can develop inappropriate activity ..
  36. Clinical Outcomes for Siblings of Children with Vesico-Ureteral Reflux
    CALEB PENNELL NELSON; Fiscal Year: 2013
    ..VUR is the retrograde flow of urine from the bladder into the ureter and kidney, and is associated with urinary tract infection (UTI) and renal injury...
  37. Chicago Prevention and Intervention Epicenter (Chicago PIE)
    ROBERT ALAN WEINSTEIN; Fiscal Year: 2013
    ..A T0/1/2 ICU and lab study of aggressive asepsis of catheter hubs is proposed. Catheter-associated urinary tract infection (CAUTI), although of lower morbidity, is a major MDRO reservoir and source of spread from hospitals ..
  38. Micro-patterned surfaces for reducing the risk of catheter-associated UTI
    SHRAVANTHI REDDY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Catheter-associated urinary tract infections (CAUTI) are the most common hospital- acquired infections, accounting for over one million cases and hospital costs of more than $500 million each year in ..
  39. An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility Testing
    VINCENT JEN JR GAU; Fiscal Year: 2013
    ..provided by applicant): Pathogens responsible for many of the common human infectious diseases such as urinary tract infection (UTI), gastroenteritis, pneumonia, and wound infections have proven to be highly adept in acquiring ..
  40. Deciphering ExPEC Virulence Mechanisms
    Matthew A Mulvey; Fiscal Year: 2012
    ..by applicant): Extraintestinal pathogenic Escherichia coli (ExPEC) cause a diverse array of diseases including urinary tract infections, sepsis, and neonatal meningitis. These infections affect 6.7 to 8...
  41. Discovery of a urine biomarker of HIV for noninvasive, point-of-care testing use
    Hans P Schlecht; Fiscal Year: 2011
    ..The presence of abnormal urine proteins is used for the noninvasive diagnosis of infections outside of the urinary tract, e.g., legionella pneumonia...
  42. Genetic Variations and Development of Vesicoureteral Reflux and Sequelae
    DAVID SULLIVAN HAINS; Fiscal Year: 2010
    ..while others develop renal scarring, hypertension and chronic kidney disease, usually following recurrent urinary tract infections (UTIs)...
  43. Rapid Point-of-Care Test Kit for the Detection of Bacteriuria Calibrated for Imme
    MARK GEISBERG; Fiscal Year: 2010
    ..development of a rapid point-of-care test kit for the direct measurement of bacteriuria as a diagnostic for urinary tract infections (UTIs)...
  44. Novel virulence and exoenzyme regulators
    ROBERT M SHANKS; Fiscal Year: 2013
    ..S. marcescens also causes many hospital acquired infections including pneumonia, endocarditis, bacteremia and urinary tract infections that are commonly resistant to current antibiotics and whose outcomes are associated with ..
  45. Training Program in Hypertension, Kidney Disease &Cell Biology
    Christie P Thomas; Fiscal Year: 2013
    ..disorders of the kidney, and clinical and translational investigation of diseases of the kidney and urinary tract. Additional opportunities will be available in related areas of physiology, biochemistry, pharmacology, and ..
  46. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Congenital malformations of the kidney and urinary tract account for up to 40% of chronic kidney failure in children less than 4 years of age...
  47. Mechanisms of Fatty Acid Metabolism in Prostate Differentiation and Disease
    DOUGLAS WILLIAM STRAND; Fiscal Year: 2013
    ..Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are a severe physical and financial burden, which, given their association with aging and ..
  48. Behavioral therapy to treat urinary symptoms in Parkinson's disease
    ELIZABETH CAMILLE VAUGHAN; Fiscal Year: 2012
    ..provided by applicant) An estimated 40% of Parkinson's disease (PD) patients suffer from lower urinary tract symptoms (LUTS) including more than 25% who have urinary incontinence (UI)...
  49. Corticosteroids for Children with Febrile Urinary Tract Infections
    Nader Shaikh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infection (UTI) is the most common serious bacterial infection in young children. In approximately 15% of cases, UTI leads to permanent renal scarring...
  50. Development of a Urine Test for the Early Detection of Colon Cancer
    Wei Song; Fiscal Year: 2012
    ..contains nucleic acids that can be used for the early detection of diseases and cancers that occur at non-urinary tract sites...
  51. Estrogen Regulation in BPH and the Lower Urinary Tract
    WILLIAM ALLEN RICKE; Fiscal Year: 2013
    ..The long term objective of this project is to develop better methods for the prevention and treatment of lower urinary tract symptoms (LUTS) in men...
  52. Vesicle Trafficking and Bacteria Invasion
    Yehia Daaka; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infections (UTI) are among the most common serious pathogenic infections in the Western world...
  53. Disposable Valved Intraurethral Catheter Feasibility
    Harvey D Homan; Fiscal Year: 2010
    ..the benefits of intermittent catheterization, but should be much easier to use and cause significantly fewer urinary tract problems...
  54. Ambulatory Case and Preventable Hospitalizations in Diabetic Kidney Disease
    Chin Lin Tseng; Fiscal Year: 2013
    ..decompensation, lower extremity amputations/ulcers, cardiovascular events, and infections (pneumonia and urinary tract infection). Key variables are subspecialty care in nephrology, endocrinology, and cardiology...
  55. TeleWellness Solutions for Chronic Conditions
    EDMUND FRANK LOPRESTI; Fiscal Year: 2013
    ..year, including preventable hospitalizations, emergency room visits and secondary conditions such as wounds, urinary tract infections, pneumonia, and sepsis...
  56. Interactions between Urological and Locomotor Systems during Treadmill Training i
    Patricia J Ward; Fiscal Year: 2012
    ..provided by applicant): Spinal cord injury (SCI) results in detrimental effects on the upper and lower urinary tract. Currently there is no effective therapy for urological dysfunction...
  57. Delayed Onset of Biofilm Formation and CAUTI with Superhydrophobic Catheters
    Sanjiv Lalwani; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Catheter-associated urinary tract infections (CAUTI) occur in >40&of the 21-50% patients that are administered indwelling catheters, annually costing a staggering $421-$451 million in medical ..
  58. A Novel Surface Sensing Pathway in Proteus mirabilis
    Philip N Rather; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infections, including prostatitis and infectious urinary stones, affect a large percentage of our veteran population...
  59. Mechanism of HigB-mediated ribosome-dependent mRNA degradation
    MARC ANTHONY SCHURECK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Proteus vulgaris (P. vulgaris) is a major cause of urinary tract bacterial infections. P. vulgaris can grow on medical equipment, such as catheters, in an antibiotic-resistant state known as biofilms...
  60. Vitamin A dependent events in urinary tract formation.
    Cathy Mendelsohn; Fiscal Year: 2009
    ..Site Congressional Districts: 15th Additional Project/Performance Site Location Organizational Name: DUNS: Street 1: Street 2: City: County: State: Province: Country: Zip/Postal Code: Project/Performance Site Congressional Districts:..
  61. Producing micturition by combined afferent and effernet electrical stimulation
    Kenneth J Gustafson; Fiscal Year: 2010
    ..resulting from neurological disorders such as spinal cord injury (SCI) is the loss of control over the lower urinary tract. SCI results in loss of voluntary control of bladder evacuation, bladder overactivity during storage (bladder ..
  62. A Web Based Self Management Intervention for Intermittent Urinary Catheter Use
    Mary H Wilde; Fiscal Year: 2013
    ..to a long-term indwelling catheter or not adhere to optimal CIC frequency, both of which can contribute to urinary tract infection...
  63. Bladder Voiding via Pudendal Nerve Block
    KENNETH GUSTAFSON; Fiscal Year: 2009
    ..The long-term goal of this research program is to develop neural prostheses to restore complete lower urinary tract function in persons with neurological disorders;particularly SCI...
  64. BACTERIAL UREASE IN THE CATHETERIZED URINARY TRACT
    HARRY MOBLEY; Fiscal Year: 1990
    ..Limited reports characterizing ureases from different bacterial species isolated from the urinary tract provide conflicting data and fail to provide a clear concept of the relatedness of heterogeneity of these ..
  65. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..activity spectrum of the pyrrhocoricin analogs, the urgent need for new antimicrobial compounds to treat human urinary tract infections (UTI) and the generally observable tissue distribution and renal clearance of peptidic drugs ..
  66. COATING OF URINARY PROTHESES TO PREVENT ENCRUSTATION
    Harmeet Sidhu; Fiscal Year: 2000
    ..Unfortunately, the use of long-term indwelling urinary catheters and stents in the urinary tract suffers from encrustation and bacterial adhesion that increases the risk for blockage of the device as well as ..
  67. PREGNANCY & HORMONE EFFECTS ON KIDNEY & URINARY TRACT
    Linda Shortliffe; Fiscal Year: 1999
    In this proposal renal and urinary tract changes associated with pregnancy, the post-partum period, and alterations in estrogen and progesterone levels will be defined...
  68. Micro-patterned surfaces for reducing the risk of catheter-associated UTI
    SHRAVANTHI REDDY; Fiscal Year: 2009
    ..Nearly half of these infections are associated with the use of a medical device, and catheter-associated urinary tract infection (UTI) is the most common type of nosocomial infection, accounting for over 40% of infections in ..
  69. Urea-dependent virulence in uropathogenic bacteria
    CARLEEN COLLINS; Fiscal Year: 2004
    ..Urease plays a significant role in virulence when expressed by urinary tract, oral, and gastroduodenal pathogens...
  70. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2009
    ..will be used to examine the mechanisms underlying the neural detection of noxious stimuli in the lower urinary tract. We areparticularly interested in identifying the chemical mediators which sensitize bladder, nociceptors and ..
  71. MOLECULAR DISSECTION OF CONGENITAL NEPHROGENIC DI
    ROBERT WILDIN; Fiscal Year: 2000
    ..from the increased water intake needed to avoid dehydration may cause permanent anatomic dilatation of the urinary tract structures, increasing the likelihood of urinary tract infections and traumatic rupture...
  72. VIRUL FACTORS OF UROPATH ESCHERICHIA COLI
    Peter Redford; Fiscal Year: 2003
    Escherichia coli is the most common cause of community-acquired urinary tract infections, resulting in an estimated eight million physician visits a year in the United States. It is also a leading cause of nosocomial infections...
  73. BACTERIAL INTERACTIONS WITH THE BLADDER MUCOSA
    Matthew Mulvey; Fiscal Year: 2002
    ..b>Urinary tract infections (UTIs) affect a large proportion of the world population and account for significant morbidity and ..
  74. POINT OF CARE DIAGNOSTICS FOR URINARY TRACT INFECTION
    KUMAR SUBRAMANIAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Urinary tract infection (UTI) is an extremely common condition that occurs in both males and females of all ages and in children...
  75. Regulaton of Urothelial Growth
    Tung Tien Sun; Fiscal Year: 2007
    The luminal surface of the entire lower urinary tract including renal pelvis, ureter, bladder and proximal urethra is lined by a cell type described in standard textbooks as the transitional epithelium or urothelium, which is ..
  76. Novel Vaccines To Evoke Bladder Mucosal Immunity
    David J Klumpp; Fiscal Year: 2010
    b>Urinary tract infection (UTI) is the second most common infectious disease and causes significant patient morbidity and economic impact...
  77. 11th International Conference on Developmental Nephrology
    Jordan A Kreidberg; Fiscal Year: 2010
    ..of ideas and concepts relating to the biology, pathophysiology, and genetics of the developing kidney and urinary tract. The current R13 application seeks funding to support travel awards for senior post-docs and fellows, as well ..