male genitalia

Summary

Summary: The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM;and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).

Top Publications

  1. ncbi Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate
    Kirsten Jarfelt
    Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Reprod Toxicol 19:505-15. 2005
  2. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
  3. ncbi Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
  4. ncbi Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
  5. pmc Viruses in the mammalian male genital tract and their effects on the reproductive system
    N Dejucq
    GERM INSERM U435, Universite de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France
    Microbiol Mol Biol Rev 65:208-31 ; first and second pages, table of contents. 2001
  6. pmc Decrease in anogenital distance among male infants with prenatal phthalate exposure
    Shanna H Swan
    Department of Obstetrics and Gynecology, University of Rochester, Rochester, New York corrected USA
    Environ Health Perspect 113:1056-61. 2005
  7. pmc Effect of endosulfan on male reproductive development
    Habibullah Saiyed
    National Institute of Occupational Health Indian Council of Medical Research, Meghani Nagar, Ahmedabad, India
    Environ Health Perspect 111:1958-62. 2003
  8. pmc Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila
    W J Swanson
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853 2703, USA
    Proc Natl Acad Sci U S A 98:7375-9. 2001
  9. pmc Coevolution of male and female genital morphology in waterfowl
    Patricia L R Brennan
    Department of Ecology and Evolutionary Biology, and Peabody Natural History Museum, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 2:e418. 2007
  10. ncbi Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female mice
    W N Jefferson
    Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 62:310-7. 2000

Detail Information

Publications206 found, 100 shown here

  1. ncbi Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate
    Kirsten Jarfelt
    Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Reprod Toxicol 19:505-15. 2005
    ..However, no combination effect was seen with respect to antiandrogenic effects, as males receiving DEHP in combination with DEHA did not exhibit more pronounced effects in the reproductive system than males receiving DEHP alone...
  2. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..Our results also show that cell proliferation in the prostate and urinary bladder of old ERbetaKO and ERalphabetaKO males is apparently normal...
  3. ncbi Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
    ..This study demonstrates that the reproductive tracts of male mice differ considerably from those of rats in expression of ARs and ERs and that caution is needed when extrapolating nuclear steroid receptor data across mammalian species...
  4. ncbi Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
    ..These data suggest that flutamide-mediated changes in AGD and nipple retention are not sensitive predictors of altered T-mediated development...
  5. pmc Viruses in the mammalian male genital tract and their effects on the reproductive system
    N Dejucq
    GERM INSERM U435, Universite de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France
    Microbiol Mol Biol Rev 65:208-31 ; first and second pages, table of contents. 2001
    ..Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system...
  6. pmc Decrease in anogenital distance among male infants with prenatal phthalate exposure
    Shanna H Swan
    Department of Obstetrics and Gynecology, University of Rochester, Rochester, New York corrected USA
    Environ Health Perspect 113:1056-61. 2005
    ..These data support the hypothesis that prenatal phthalate exposure at environmental levels can adversely affect male reproductive development in humans...
  7. pmc Effect of endosulfan on male reproductive development
    Habibullah Saiyed
    National Institute of Occupational Health Indian Council of Medical Research, Meghani Nagar, Ahmedabad, India
    Environ Health Perspect 111:1958-62. 2003
    ..Our study results suggest that endosulfan exposure in male children may delay sexual maturity and interfere with sex hormone synthesis. Our study is limited by small sample size and nonparticipation...
  8. pmc Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila
    W J Swanson
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853 2703, USA
    Proc Natl Acad Sci U S A 98:7375-9. 2001
    ..The evolutionary EST approach applied here to identify putative targets of adaptive evolution is readily applicable to other tissues and organisms...
  9. pmc Coevolution of male and female genital morphology in waterfowl
    Patricia L R Brennan
    Department of Ecology and Evolutionary Biology, and Peabody Natural History Museum, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 2:e418. 2007
    ..Our results suggest that females have evolved a cryptic anatomical mechanism of choice in response to forced extra-pair copulations...
  10. ncbi Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female mice
    W N Jefferson
    Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 62:310-7. 2000
    ..These studies provide information useful in studying the role of both ER subtypes in normal differentiation, and they provide indications of differential tissue expression during development...
  11. pmc Coevolution between harmful male genitalia and female resistance in seed beetles
    Johanna Rönn
    Evolutionary Biology Centre, Department of Ecology and Evolution, Animal Ecology, University of Uppsala, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 104:10921-5. 2007
    ..The spectacular evolution of male genitalia that impose physical injury on females during mating has often been suggested to be a product of sexually ..
  12. ncbi Disruption of male reproductive tract development by administration of the xenoestrogen, nonylphenol, to male newborn rats
    P C Lee
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    Endocrine 9:105-11. 1998
    ..Our results suggest that exposure of neonatal male rats to NP is potentially deleterious to their reproductive development and affects their reproductive performance...
  13. ncbi Developmental stability and adaptive variability of male genitalia in sexually dimorphic beetles
    Kazuo Kawano
    Food Resources Education and Research Center, Faculty of Agriculture, Kobe University, Uzurano, Kasai, 675 2103, Japan
    Am Nat 163:1-15. 2004
    ..beetle species in 16 genera of families Scarabaeidae and Lucanidae, Coleoptera, in 53 locations revealed that male genitalia size was consistently and distinctly less variable than that of other body parts within the same population, ..
  14. ncbi A review of the psychosocial issues for nurses in male genitalia-related care
    Yu Li Zang
    School of Nursing, Shandong University, Jinan, Shandong Province, China
    J Clin Nurs 17:983-98. 2008
    This literature review aimed to highlight psychosocial issues for nurses in the practice of male genitalia-related care so as to guide the improvement of the teaching and practice of male genitalia-related care.
  15. ncbi Male accessory gland secretions: modulators of female reproductive physiology and behavior
    Cedric Gillott
    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, SK S7N 5E2, Canada
    Annu Rev Entomol 48:163-84. 2003
    ..In a few species the secretions include noxious chemicals. These are sequestered by developing eggs that are thereby protected from predators and pathogens when laid...
  16. ncbi Development and maturation of the male reproductive system
    M Sue Marty
    Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674, USA
    Birth Defects Res B Dev Reprod Toxicol 68:125-36. 2003
  17. pmc DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate
    K M Kozopas
    Howard Hughes Medical Insitute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5323 USA
    Genes Dev 12:1155-65. 1998
    ....
  18. ncbi Responses of thalamic neurons to input from the male genitalia
    Charles H Hubscher
    Department of Anatomical Sciences and Neurobiology, University of Louisville, Kentucky 40292, USA
    J Neurophysiol 89:2-11. 2003
    ..Taken together, the data demonstrate the existence of thalamic neurons with inputs from the male genitalia with widespread somatovisceral convergence...
  19. ncbi Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy
    M Ema
    National Institute of Health Sciences, Osaka Branch, 1 1 43 Hoenzaka, Chuo Ku, 540 0006, Osaka, Japan
    Reprod Toxicol 15:189-94. 2001
    ....
  20. ncbi Estrogen receptor-alpha is required by the supporting somatic cells for spermatogenesis
    D Mahato
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD C4 01, PO Box 12233, Research Triangle Park, NC 27709 2233, USA
    Mol Cell Endocrinol 178:57-63. 2001
    ....
  21. ncbi Tokens of love: functions and regulation of Drosophila male accessory gland products
    M F Wolfner
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
    Insect Biochem Mol Biol 27:179-92. 1997
    ....
  22. ncbi Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differen
    C Wolf
    Endocrinology Branch, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27711, USA
    Toxicol Ind Health 15:94-118. 1999
    ..Only in depth in vitro studies will reveal the degree to which one can rely upon in vivo studies, like those presented here, to predict the cellular and molecular mechanisms of developmental toxicity...
  23. ncbi Identification and comparative analysis of accessory gland proteins in Orthoptera
    W Evan Braswell
    Department of Biology, New Mexico State University, Las Cruces, NM, USA
    Genome 49:1069-80. 2006
    ..Despite rapid nucleotide sequence divergence, there appears to be functional conservation of protein classes among Drosophila and cricket taxa...
  24. ncbi Host defense proteins of the male reproductive tract
    Susan H Hall
    Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Androl 23:585-97. 2002
  25. ncbi A time-sequence functional analysis of mating behaviour and genital coupling in Drosophila: role of cryptic female choice and male sex-drive in the evolution of male genitalia
    S Jagadeeshan
    Department of Biology, McMaster University, Hamilton, ON, Canada
    J Evol Biol 19:1058-70. 2006
    b>Male genitalia in Drosophila exemplify strikingly rapid and divergent evolution, whereas female genitalia are relatively invariable...
  26. pmc Anogenital distance in human male and female newborns: a descriptive, cross-sectional study
    Eduardo Salazar-Martinez
    National Institute of Public Health, Av Universidad 655, Col Santa Ma Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
    Environ Health 3:8. 2004
    ..Because AGD has been an easy-to-measure, sensitive outcome in animals studies, we developed and implemented an anthropometric protocol for measurement of AGD in human males as well as females...
  27. ncbi Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 32:79-90. 2004
    ..While the morphology and incidence of this DBP-induced testicular developmental lesion has been fully characterized by this study, the detailed pathogenesis warrants further investigation...
  28. ncbi Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy
    Barry S McIntyre
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 65:62-70. 2002
    ....
  29. ncbi The form of sexual selection on male genitalia cannot be inferred from within-population variance and allometry - a case study in Aquarius remigis
    Angéline Bertin
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245 0549, USA
    Evolution 61:825-37. 2007
    ..We discuss the implications of this finding and propose future directions for improving our current understanding of genital evolution in arthropods...
  30. ncbi Allometry of male genitalia in a species of soldier beetle: support for the one-size-fits-all hypothesis
    Stephen Bernstein
    Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder 80309, USA
    Evolution 56:1707-10. 2002
    Hypotheses about the functions of the male genitalia and the male scape in insects were tested by measuring the slopes of allometric relations in six populations of Chauliognathus scutellaris...
  31. ncbi When morphometry meets genetics: inferring the phylogeography of Carabus solieri using Fourier analyses of pronotum and male genitalia
    S Garnier
    INRA Centre de Biologie et de Gestion des Populations, Campus International de Baillarguet, Montferrier sur Lez, France
    J Evol Biol 18:269-80. 2005
    ..solieri differentiated during the last glaciation events before recolonizing the actual range of the species. It also indicates a large introgression between the two differentiated entities in the centre of the range...
  32. pmc Evolution of male genitalia: environmental and genetic factors affect genital morphology in two Drosophila sibling species and their hybrids
    Ignacio M Soto
    Departamento de Ecologia, Genetica y Evolucion, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    BMC Evol Biol 7:77. 2007
    ..koepferae. Genital morphology in interspecific hybrids was examined and compared to the corresponding parental lines...
  33. ncbi Morphology of male reproductive system in three species of Trypoxylon (Trypargilum) Richards (Hymenoptera: Crabronidae)
    Polyana A Moreira
    Depto Biologia Animal, Univ Federal de Viçosa, Vicosa, MG, 36570 000
    Neotrop Entomol 37:429-35. 2008
    ..Sexually mature individuals have all spermatogenesis stages in their follicles. Sperms are released from testes in bundles which are disorganized inside seminal vesicles...
  34. ncbi Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat
    Katie J Turner
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 68:174-83. 2002
    ..Based on observed fetotoxicity at 20 mg/kg/day, the lowest observed adverse effect level (LOAEL) for developmental effects can be lowered from 25 to 20 mg/kg/day...
  35. pmc In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 165:1015-22. 2007
    ..If DDE has important antiandrogenic action in humans, it may be manifest only at higher levels of exposure or via effects on other outcomes...
  36. ncbi ESP13.2, a member of the beta-defensin family, is a macaque sperm surface-coating protein involved in the capacitation process
    Ashley I Yudin
    Department of Obstetrics and Gynecology, Division of Reproductive Biology, University of California, Davis 94923, USA
    Biol Reprod 69:1118-28. 2003
    ..These findings suggest that the beta-defensin, ESP13.2, has a function in the capacitation of macaque spermatozoa and may modulate sperm surface-receptor presentation at the time of fertilization...
  37. ncbi Subcompartmentalization of HIV-1 quasispecies between seminal cells and seminal plasma indicates their origin in distinct genital tissues
    Shirish Paranjpe
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    AIDS Res Hum Retroviruses 18:1271-80. 2002
    ..These findings provide for the first time evidence of subcompartmentalization of HIV-1 in male genital organs and suggest that intervention strategies such as vasectomy may not prevent sexual transmission...
  38. pmc Genital morphology and fertilization success in the dung beetle Onthophagus taurus: an example of sexually selected male genitalia
    Clarissa M House
    Evolutionary Biology Research Group, Department of Zoology, University of Western Australia, Nedlands, WA 6009, Australia
    Proc Biol Sci 270:447-55. 2003
    In animals with internal fertilization and promiscuous mating, male genitalia show rapid and divergent evolution...
  39. ncbi Molecular and genetic regulation of testis descent and external genitalia development
    Thomas Klonisch
    Department of Anatomy and Cell Biology, Medical Faculty, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Dev Biol 270:1-18. 2004
    ....
  40. ncbi Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat
    Christopher J Bowman
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:393-406. 2003
    ..In summary, prenatal exposure to finasteride specifically inhibited DHT-mediated development with little to no change in T-mediated development...
  41. pmc Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor
    Paul Martin Holterhus
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genome Biol 4:R37. 2003
    ....
  42. ncbi Viruses in semen and male genital tissues--consequences for the reproductive system and therapeutic perspectives
    N Dejucq-Rainsford
    GERM INSERM U435, Universite de Rennes I, Campus de Beaulieu, 35 042 Rennes, France
    Curr Pharm Des 10:557-75. 2004
    ..The use of medically assisted reproduction as a therapeutic tool in serodiscordant couples, as well as treatment strategies that need to be developed in order to eradicate these viruses from the male genital tract, are discussed...
  43. ncbi Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis
    Vickie S Wilson
    Reproductive Toxicology Division, United States Environmental Protection Agency, NHEERL, ORD, MD 72, Research Triangle Park, NC 27711, USA
    Toxicol Lett 146:207-15. 2004
    ..These results provide the first demonstration of PE-induced alteration of insl3 mRNA in the fetal male rat testis...
  44. ncbi Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures
    Stine Broeng Metzdorff
    Department of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicol Sci 98:87-98. 2007
    ..Exposure to antiandrogens, which appears to exert only small effects when judged on a chemical-by-chemical basis, may induce marked responses in concert with, possibly unrecognized, similarly acting chemicals...
  45. ncbi Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz
    Anne Marie Vinggaard
    Institute of Food Safety and Nutrition, Danish Veterinary and Food Administration, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicol Sci 69:344-53. 2002
    ..However, differential effects on levels of FSH, T(4), and TSH indicate that other modes of action apart from the pure AR antagonism might play a role in vivo...
  46. ncbi The effect of oestrogen and testosterone on the urethral seam of the developing male mouse genital tubercle
    S Yucel
    UCSF Children s Medical Center, Departments of Urology and Paediatrics, University of California, San Francisco, USA
    BJU Int 92:1016-21. 2003
    ..g. hypospadias...
  47. ncbi Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats
    Kaori Miyata
    Environmental Health Science Lab, Sumitomo Chemical Co, Ltd, 3 1 98, Kasugade Naka, Konohana ku, Osaka 554 8558, Japan
    J Toxicol Sci 27:19-33. 2002
    ..This study indicates that the most sensitive parameter is AGD, whereby reduction was observed at 2.5 mg/kg. A clear no-effect level (NOEL: 0.6 mg/kg) was obtained in this perinatal study of an antiandrogenic chemical...
  48. ncbi Differential expression of estrogen receptors alpha and beta in the reproductive tracts of adult male dogs and cats
    Rong Nie
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln, Urbana, IL 61802, USA
    Biol Reprod 66:1161-8. 2002
    ..However, as in other species, the efferent ductules remained the region of highest concentration of ERalpha...
  49. ncbi The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
    J Ostby
    Endocrinology Branch, National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, NC 27711, USA
    Toxicol Ind Health 15:80-93. 1999
    ....
  50. ncbi The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo
    Christine Nellemann
    Institute of Food Safety and Nutrition, Danish Veterinary and Food Administration, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicol Sci 71:251-62. 2003
    ....
  51. pmc Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat
    Ulla Hass
    Danish Institute for Food and Veterinary Research, Department of Toxicology and Risk Assessment, Soborg, Denmark
    Environ Health Perspect 115:122-8. 2007
    ....
  52. ncbi A mixture of seven antiandrogens induces reproductive malformations in rats
    Cynthia V Rider
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA
    Int J Androl 31:249-62. 2008
    ....
  53. ncbi The evolution of male genitalia: patterns of genetic variation and covariation in the genital sclerites of the dung beetle Onthophagus taurus
    C M House
    Evolutionary Biology Research Group, School of Animal Biology, University of Western Australia, Nedlands WA, Australia
    J Evol Biol 18:1281-92. 2005
    ..has direct implications for a male's fertilization success and the resulting sexual selection acting on male genitalia is predicted to maintain high levels of additive genetic variance...
  54. ncbi Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice
    C S Rosenfeld
    Department of Animal Sciences, University of Missouri, Columbia 65211, USA
    Endocrinology 139:2982-7. 1998
    ....
  55. ncbi Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development
    Vickie S Wilson
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Laboratory, Reproductive Toxicology Division, Research Triangle Park, NC 27711, USA
    Int J Androl 31:178-87. 2008
    ..Furthermore, the effects of mixtures of these compounds are just beginning to be explored...
  56. pmc Human papillomavirus in men: comparison of different genital sites
    L V Aguilar
    Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Mexico DF, Mexico
    Sex Transm Infect 82:31-3. 2006
    ..To elucidate which anatomical sites need to be sampled to detect human papillomavirus (HPV) infection in the lower male genital tract...
  57. pmc Genetic analysis of a morphological shape difference in the male genitalia of Drosophila simulans and D. mauritiana
    J Liu
    Department of Zoology, Duke University, Durham, North Carolina 27708, USA
    Genetics 142:1129-45. 1996
    ..Although there is some evidence of partial dominance of mauritiana alleles and for epistasis, the pattern of inheritance is largely additive...
  58. ncbi Does our environment affect our fertility? Some examples to help reframe the question
    Shanna H Swan
    Center for Reproductive Epidemiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA
    Semin Reprod Med 24:142-6. 2006
    ..These methods, rather than trend analyses, may lead more directly--and more persuasively--to identifying the role of environment in human fertility...
  59. pmc Nonclassic congenital lipoid adrenal hyperplasia: a new disorder of the steroidogenic acute regulatory protein with very late presentation and normal male genitalia
    Bo Y Baker
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    J Clin Endocrinol Metab 91:4781-5. 2006
    ....
  60. ncbi Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Androl 29:140-7; discussion 181-5. 2006
    ..However humans are exposed to and produce the critical phthalate metabolites that have been detected in blood of the general population, in children and also human amniotic fluid...
  61. ncbi Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract
    Amar A Patil
    Department of Animal Science, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Physiol Genomics 23:5-17. 2005
    ..Existence of such a vast array of beta-defensins in the male reproductive tract suggests that these genes may play a dual role in both fertility and host defense...
  62. ncbi One tool, many uses: precopulatory sexual selection on genital morphology in Aquarius remigis
    A Bertin
    Department of Biology, University of California Riverside, CA, USA
    J Evol Biol 18:949-61. 2005
    ..These results highlight the multiple functions of genital organs and the importance of both precopulatory and post-copulatory sexual selection in shaping the remarkable diversity of male genitalia in insects.
  63. ncbi Rapid diversification of male genitalia and mating strategies in Ohomopterus ground beetles
    Y Takami
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan
    J Evol Biol 20:1385-95. 2007
    We analysed evolutionary diversification and covariation in male genitalia and four mating traits related to sexual selection, i.e...
  64. ncbi Decreased expression of IGF-II and its binding protein, IGF-binding protein-2, in genital skin fibroblasts of patients with complete androgen insensitivity syndrome compared with normally virilized males
    M W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:4741-6. 2001
    ....
  65. ncbi A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior
    F S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Toxicol Ind Health 14:239-60. 1998
    ..A new approach to studying physiologically relevant doses of environmental endocrine disruptors is discussed, particularly with regard to the development of the reproductive organs, the brain, and behavior...
  66. ncbi Effects of environmental antiandrogens on reproductive development in experimental animals
    L E Gray
    Endocrinology Branch, RTD, NHEERL, ORD, USEPA, RTP, NC, 27711, USA
    Hum Reprod Update 7:248-64. 2001
    ..Knowledge of the tissue concentrations of the active toxicants also would provide an important link to in-vitro studies, which provide more useful mechanistic information when they are executed at relevant concentrations...
  67. ncbi Involvement of male genitalia in leprosy
    B Kumar
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Lepr Rev 72:70-7. 2001
    ..Genital lesions were observed in 6.6% of all male cases of leprosy. They were seen most frequently in lepromatous leprosy (25.8%), followed by borderline lepromatous (13.3%) and borderline tuberculoid (1.4%) leprosy...
  68. ncbi Differential expression of oestrogen receptor alpha and beta proteins in the testes and male reproductive system of human and non-human primates
    P T Saunders
    MRC Human Reproductive Sciences Unit, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Mol Hum Reprod 7:227-36. 2001
    ..The widespread expression of ERbeta suggests that it is the primary target for modulation of tissue function via oestrogenic ligands in the male reproductive system...
  69. ncbi The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    L G Parks
    Endocrinology Branch, MD 72, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 58:339-49. 2000
    ..These data indicate that DEHP disrupts male rat sexual differentiation by reducing T to female levels in the fetal male rat during a critical stage of reproductive tract differentiation...
  70. ncbi Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals
    C Gupta
    Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Proc Soc Exp Biol Med 224:61-8. 2000
    ..The chemicals are able to induce malformation even in the absence of fetal testosterone; however, they are more effective in the presence of testosterone...
  71. ncbi Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat
    L E Gray
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Ind Health 15:48-64. 1999
    ....
  72. ncbi Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring
    Anne Marie Vinggaard
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, DK 2860 Søborg, Denmark
    Toxicol Sci 85:886-97. 2005
    ..Overall these results strongly indicate that prochloraz feminizes the male offspring after perinatal exposure, and that these effects are due, at least in part, to diminished fetal steroidogenesis...
  73. ncbi Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate
    Makoto Ema
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501 Tokyo, Japan
    Reprod Toxicol 17:407-12. 2003
    ..The present data indicate that MBeP produces adverse effects on the development of the reproductive system in male offspring and suggest that MBeP may be responsible for the antiandrogenic effects of BBP...
  74. ncbi Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome
    Jane S Fisher
    The University of London, School of Pharmacy, Department of Toxicology, 29 39 Brunswick Square, London, WC1N 1AX, UK
    Reproduction 127:305-15. 2004
    ....
  75. ncbi Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate
    Christina M Carruthers
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res B Dev Reprod Toxicol 74:277-85. 2005
    ..This study was conducted to identify the critical days for the abnormal development of the male reproductive tract, specifically the testis and epididymis...
  76. pmc Meeting report: measuring endocrine-sensitive endpoints within the first years of life
    Tye E Arbuckle
    Biostatistics and Epidemiology Division, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 116:948-51. 2008
    ....
  77. ncbi Oestrogen, its receptors and function in the male reproductive tract - a review
    R A Hess
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln, Urbana, IL 61802, USA
    Mol Cell Endocrinol 178:29-38. 2001
    ..It was found that oestrogen receptor-alpha is essential for fluid reabsorption in the efferent ductules and in the absence of expression the male is infertile...
  78. ncbi Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias
    A Allera
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857, USA
    J Clin Endocrinol Metab 80:2697-9. 1995
    ....
  79. ncbi Effects of altered food intake during pubertal development in male and female wistar rats
    Susan C Laws
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 100:194-202. 2007
    ....
  80. ncbi Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat
    Kembra L Howdeshell
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 102:371-82. 2008
    ..05-1.5 mug/kg/day did not significantly affect any male endpoint in the current study. These results demonstrate that developmental exposure to oral micromolar doses of EE can permanently disrupt the reproductive tract of the male rat...
  81. ncbi The antiviral drug ribavirin reversibly affects the reproductive parameters in the male Wistar rat
    K Narayana
    Department of Anatomy, Centre for Basic Sciences, Kasturba Medical College, Bejai, Mangalore, Karnataka, India
    Folia Morphol (Warsz) 64:65-71. 2005
    ..In conclusion, ribavirin is gonadotoxic in male rats but the effects are reversible after a period of 105 days. However, the endocrine-disrupting properties of ribavirin persist beyond this period...
  82. ncbi Chlropyrifos-methyl shows anti-androgenic activity without estrogenic activity in rats
    Hwan Goo Kang
    National Veterinary Research and Quarantine Service, Division of Toxicology, 480, Anyang 6 dong, Anyang city 430 824, Republic of Korea
    Toxicology 199:219-30. 2004
    ..In conclusion, CPM dose not show estrogenic and anti-estrogenic activity in immature female rats, but it represents anti-androgenic activity by inhibition of the TP-stimulated increase of the weight of accessory sex organs...
  83. ncbi Sexual differentiation of the copulatory neuromuscular system in green anoles (Anolis carolinensis): normal ontogeny and manipulation of steroid hormones
    Melissa M Holmes
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    J Comp Neurol 489:480-90. 2005
    ....
  84. ncbi Anabolic effect of Hibiscus rosasinensis Linn. leaf extracts in immature albino male rats
    S O Olagbende-Dada
    Department of Pharmacognosy, Faculty of Pharmacy, College of Medicine, University of Lagos, Idi Araba, Lagos, Nigeria
    Nig Q J Hosp Med 17:5-7. 2007
    ..Cold aqueous extract of Hibiscus rosasinensis leaves is reported by local traditional practioners in Western Nigeria to be aphrodisiac...
  85. ncbi Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat
    Amber K Goetz
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Toxicol Sci 95:227-39. 2007
    ..These reproductive effects are consistent with the disruption of testosterone homeostasis as a key event in the mode of action for triazole-induced reproductive toxicity...
  86. ncbi Mikania laevigata syrup does not induce side effects on reproductive system of male Wistar rats
    Carlos Graça
    Department of Pharmacology, Sector of Biological Sciences, Universidade Federal do Parana, Centro Politecnico, Jardim das Americas, Curitiba, PR, Brazil
    J Ethnopharmacol 111:29-32. 2007
    ..Results therefore suggest absence of male reproductive toxicity of the Mikania laevigata syrup at tested doses...
  87. ncbi Role of early GnRH administration in sexual behavior disorders of rat pups perinatally exposed to lead
    H S Spinosa
    Department of Pathology, Faculty of Veterinary Medicine and Zootechny, , , Brazil
    Neurotoxicol Teratol 23:203-12. 2001
    ..These results show that perinatal exposure to Pb had a dose-dependent effect on the sexual behavior of rats and that a decrease in GnRH source in the offspring was probably involved in the reduction of their sexual performance...
  88. ncbi Testosterone secretion and semen plasma enzyme activity in rams with genital pathology stimulated with GnRH
    M Aksoy
    Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey
    Theriogenology 57:1907-16. 2002
    ..Focal testicular degeneration did not influence AST, alkaline phosphatase (ALP) and LDH activity in semen plasma...
  89. ncbi Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: II. Effects on male puberty and the reproductive tract
    O Putz
    Department of Urology (M/C 955, College of Medicine, University of Illinois, Chicago, Illinois 60612-7310, USA
    Biol Reprod 65:1506-17. 2001
    ..F344 rats exhibited greater estrogen sensitivity on PND 90. Despite this heightened responsiveness, F344 rats did not exhibit a low-dose effect for any endpoint. These low-dose responses to estradiol are organ and strain specific...
  90. ncbi The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats
    Mustafa Sonmez
    Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, 23119 Elazig, Turkey
    Reprod Toxicol 23:226-31. 2007
    ..The administration of Mlt or VE can prevent adverse effects of Hcy on the plasma antioxidant enzyme activities, testosterone level, epididymal sperm count and motility in male rats...
  91. ncbi Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats
    Sang Hee Jeong
    Toxicology Division, National Veterinary Research and Quarantine Service, 480, Anyang 430 016, Republic of Korea
    Toxicology 208:49-62. 2005
    ....
  92. ncbi Effects of Pueraria mirifica, an herb containing phytoestrogens, on reproductive organs and fertility of adult male mice
    Sukanya Jaroenporn
    Interdepartment of Physiology, Faculty of Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
    Endocrine 30:93-101. 2006
    ..Although PM-100 can cause some moderate impairment, no persistent effects were observed. Most of PM-treated mice increased the mating efficiency after stop treatment...
  93. ncbi Ultrastructural evidence for secretion from the epithelium of ampulla ductus deferentis of the fan-throated lizard Sitana ponticeriana Cuvier
    M A Akbarsha
    Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India
    J Morphol 266:94-111. 2005
    ..It appears that within the Squamata, the ductal ampulla differs in structure as well as function. We suggest that the ductal ampulla of agamid lizards is a composite gland of the ampulla ductus deferentis and seminal vesicles of mammals...
  94. ncbi trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo
    Sunhee Shin
    College of Veterinary Medicine, Chungbuk National University, Heungdeok Gu, Cheongju, Chungbuk 361 763, Korea
    Arch Pharm Res 31:83-7. 2008
    ..In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility...
  95. ncbi Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effect
    Osamu Takahashi
    Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health, 24 1, Hyakunincho 3 chome, 169 0073 Shinjuku ku, Tokyo, Japan
    Arch Toxicol 80:225-41. 2006
    ..These results suggest that BM and TM are weakly toxic, possibly through an estrogenic mechanism to male reproductive organs in mice as well as rats, while MM and ME may be the direct testicular toxins in rats but not mice...
  96. ncbi Xenoendocrine pollutants may reduce size of sexual organs in East Greenland polar bears (Ursus maritimus)
    Christian Sonne
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, P O Box 358, DK 4000 Roskilde, Denmark
    Environ Sci Technol 40:5668-74. 2006
    ..This may pose a riskto this polar bear subpopulation in the future because of reduced sperm and egg quality/quantity and uterus and penis size/robustness...
  97. ncbi A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats
    Anderson J M Andrade
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, Berlin, Germany
    Toxicology 228:85-97. 2006
    ..The lowest observed adverse effect levels (LOAELs) for these effects were 15 and 5 mg/kg/day, respectively. Therefore, the no observed adverse effect level (NOAEL) for this study can be set at 1.215 mg/kg/day...
  98. ncbi Reproductive effects in male rats exposed to diuron
    Glaura S A Fernandes
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Reprod Toxicol 23:106-12. 2007
    ....
  99. ncbi Neonatal methyl parathion exposure affects the growth and functions of the male reproductive system in the adult rat
    K Narayana
    Department of Anatomy, Faculty of Medicine, HSC, Kuwait University, Safat, Kuwait
    Folia Morphol (Warsz) 65:26-33. 2006
    ..These findings are important to the general public, as there is a chance of children being exposed to this pesticide...
  100. ncbi Effect of gestational exposure to nonylphenol on the development and fertility of mouse offspring
    Naoko Kimura
    Laboratory of Animal Reproduction, Faculty of Agricultural Science, Yamagata University, Tsuruoka, Japan
    J Reprod Dev 52:789-95. 2006
    ..9%) and NP1/10 (female: 9.8%) groups. These results suggest that exposure to NP in utero possibly affects the body weight and some reproductive organ weights, but does not influence the potential fertility of the F1 generation...
  101. ncbi Effects of maternal 4-tert-octylphenol exposure on the reproductive tract of male rats at adulthood
    Müfide Aydoğan
    Department of Biology, Faculty of Science, University of Hacettepe, 06532 Beytepe, Ankara, Turkey
    Reprod Toxicol 22:455-60. 2006
    ..The results of this study demonstrate that maternally injected OP causes adverse effects on male reproductive tract at adulthood, especially on sperm structure...

Research Grants64

  1. Assessment of Penile Autonomic Innervation
    Claire Yang; Fiscal Year: 2007
    ..in the corpus cavernosum using standard clinical electrophysiological equipment modified for use in the male genitalia. The presence of electrical impulses, stimulated by activation of sympathetic fibers, will indicate the ..
  2. Lymphatic Filariasis Transmission and Elimination in Papua New Guinea
    Daniel J Tisch; Fiscal Year: 2013
    ..bore parasitic worm "Neglected Tropical Disease" (NTD) that causes elephantiasis, disfigurement of the male genitalia and painful swelling of the extremities...
  3. Human Papillomavirus Infection in Perinatally HIV-infected Adolescents in Asia
    Annette H Sohn; Fiscal Year: 2013
    ..Detecting HPV infection in the cervix, vagina, anus, oral cavity, and male genitalia soon after sexual debut and monitoring virus clearance and cervical intraepithelial neoplasia over time will ..
  4. Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne M Marrazzo; Fiscal Year: 2010
    ..sexual behavior and failure of BV to resolve in women, supporting the hypothesis that BVAB colonization of male genitalia may serve as a reservoir for re-infection of female partners...
  5. A Genomic Analysis of Sexual Trait Variation Within and Between Species
    STUART JOHN MACDONALD; Fiscal Year: 2013
    ..Rapid evolution is a general feature of male genitalia in animals, and the posterior lobe also exhibits significant within-species variation...
  6. SEGMENTAL DIFFERENTIATION IN THE NERVOUS SYSTEM
    Eduardo Macagno; Fiscal Year: 1993
    ..It comprises the study of an interaction between the male genitalia and the two central ganglia that innervate it...
  7. Genomic analysis of doublesex regulation in development of Drosophila genitalia
    JOHN PAUL MASLY; Fiscal Year: 2010
    ..Second, the set of male genitalia-specific genes identified in the previous experiment will be used to investigate expression differences ..
  8. US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN
    Shanna Swan; Fiscal Year: 2001
    ....
  9. Environmental Endocrine Disrupters 2008 Gordon Research Conference
    Shanna Swan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  10. Prenatal development, spatial ability, and hippocampus
    Rebecca Herman; Fiscal Year: 2004
    ..abstract_text> ..
  11. Natural variation in Drosophila female postmating traits
    DAVID BEGUN; Fiscal Year: 2008
    ..abstract_text> ..
  12. Computations of Fold Changes in Evolution of Proteins
    Nick Grishin; Fiscal Year: 2006
    ..Finally, we will perform in silico evolution of model proteins under functional constraints and compare the results to those deduced from the analysis of natural sequences and structures. ..
  13. PERIODONTAL DISEASE:ROLE OF ABERRANT Ig GLYCOSYLATION
    Jiri Mestecky; Fiscal Year: 2006
    ..Results of these studies will generate information concerning previously unexplored inflammatory pathways that participate in the development of PD. ..
  14. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2006
    ..abstract_text> ..
  15. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
    ..abstract_text> ..
  16. An MMi CellCut Laser Mircrodissection System
    Dennis Brown; Fiscal Year: 2006
    ..access and expertise to the MGH research community will be an important part of our mission and bridges the gap between pure microscopy studies and functional genomics that take advantage [unreadable] [unreadable] [unreadable]..
  17. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  18. Synthetic smooth muscle cell-selective promoters
    BRIAN HERRING; Fiscal Year: 2006
    ..Together these studies will provide a comprehensive analysis of the mechanisms regulating smooth muscle cell-selective gene expression in the genitourinary tract. [unreadable] [unreadable] [unreadable]..
  19. Blocking immune evasion as a novel HSV vaccine approach
    HARVEY MICHAEL FRIEDMAN; Fiscal Year: 2010
    ..whether gD subunit vaccines are more effective at protecting mucosal (female genitalia) than epidermal (male genitalia) sites...
  20. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..Thus, we exploit the powerful genetics of Drosophila to elucidate efficiently the molecules and gene pathways needed to start development in humans. ..
  22. HERPES SIMPLEX VIRUS FC RECEPTOR
    Harvey Friedman; Fiscal Year: 2009
    ..This proposal addresses fundamental properties of HSV-1 gE, gl and Us9 related to infection of neurons and immune evasion. Understanding these activites may lead to novel therapies and better vaccines. ..
  23. Genetic Regulation of Mating Behavior in C. elegan Males
    Luis Garcia; Fiscal Year: 2009
    ..Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating. ..
  24. MALE UROGENITAL FUNCTION AND CHRONIC SPINAL CORD INJURY
    Charles Hubscher; Fiscal Year: 2009
    ..Parallel electrophysiological, neuroanatomical and behavioral studies are once again proposed. ..
  25. Nicotinic Acetylcholine Receptors in Neural Development
    Rae Nishi; Fiscal Year: 2009
    ..These studies will make a significant contribution towards the detailed understanding of how nicotinic signaling contributes to the development of the nervous system. ..
  26. Natural History of CIN2 in Adolescents
    Anna Barbara Moscicki; Fiscal Year: 2007
    ..S. and specifically assess how best to modify cytology-based screening, utilize HPV diagnostics, and tailor aoDrooriate follow-uo strategies for adolescents and vouna women diaanosed with CIN 2 ..
  27. Progesterone Action in the Uterus of Mice and Humans
    Jeffrey Pollard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. 25th Annual Symposium on Nonhuman Primate Models for AIDS
    Christopher Miller; Fiscal Year: 2007
    ..This format has been successfully followed using NCRR support for the previous Annual symposium. [unreadable] [unreadable] [unreadable]..
  29. Familial IgA Nephropathy: Genetic and Metabolic Studies
    Jiri Mestecky; Fiscal Year: 2006
    ..abstract_text> ..
  30. Stromal Epithelial Interactions in Breast Cancer
    Gerald Cunha; Fiscal Year: 2004
    ..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
  31. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  32. EINSTEIN TRANSGENIC AND GENE TARGETING COURSE
    Jeffrey Pollard; Fiscal Year: 2004
    ..Considerable emphasis in placed upon these interactions so that experimental procedures can be developed by the students in the future that address specific human diseases particularly cancer. ..
  33. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 2001
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  34. DEVELOPMENT OF THE PRIMATE IMMUNOLOGY RESOURCE
    Christopher Miller; Fiscal Year: 2003
    ..This type of sustained support for assay development is required if immune studies in non-human primates are going to significantly advance in the near future. ..
  35. MUCOSAL VACCINES AGAINST GONORRHEA
    Michael Russell; Fiscal Year: 2003
    ..The information gained about genital tract immunity and the techniques used may also be applicable to other sexually transmitted diseases. ..
  36. GENDER IDENTITY--SEX REASSIGNMENT DUE TO GENITAL DEFECTS
    William Reiner; Fiscal Year: 2003
    ..The results of these studies should lead to more rational, research-informed, surgical and psychiatric approaches to these children and their families. ..
  37. Ultraview LCI Spinning Disk Confocal Microscope System
    Dennis Brown; Fiscal Year: 2003
    ..Thus, a wide-range of projects and investigators will benefit from this equipment, which will be integrated into a Core facility that has been operational for over 15 years. ..
  38. ANNUAL SYMPOSIUM ON NONHUMAN PRIMATE MODELS FOR AIDS
    Christopher Miller; Fiscal Year: 2002
    ..There will also be an evening banquet at the Monterey Bay Aquarium. ..
  39. IRON INDUCED APOPTOSIS IN NEURODEGENERATIVE DISEASE
    Rae Nishi; Fiscal Year: 2002
    ..abstract_text> ..
  40. Ocular Control of Melatonin Regulation: Action Spectrum
    George Brainard; Fiscal Year: 2004
    ..Ultimately, this research will lead to the identification of photoreceptors implicated in the use of light as a therapeutic intervention. ..
  41. SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
  42. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..abstract_text> ..
  43. MECHANISMS OF TROPHIC MOLECULES IN NEURONAL DEVELOPMENT
    Rae Nishi; Fiscal Year: 2005
    ..abstract_text> ..
  44. Role of Oral Epithelial Cells in HIV-1 Transmission
    Zina Moldoveanu; Fiscal Year: 2005
    ..The data generated will contribute to the understanding of mucosal HIV-1 transmission. ..
  45. HETEROSEXUAL TRANSMISSION OF HHV 8 IN KENYA
    King Holmes; Fiscal Year: 2005
    ..A better understanding of heterosexual transmission of HHV-8 is essential for the development of interventions strategies to prevent HHV-8 infection and associated malignancy. ..
  46. TELOKIN GENE REGULATION IN SMOOTH MUSCLE
    BRIAN HERRING; Fiscal Year: 2005
    ..The function of SRFs' interaction with these proteins will be elucidated. ..
  47. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
  48. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002
    ....
  49. Sex, SLE, and Signal Transduction
    Jill Jacobson; Fiscal Year: 2005
    ..abstract_text> ..
  50. 2006 Environmental Endocrine Disruptors Gordon Conference
    Rex Hess; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  51. 2006 Reproductive Tract Biology Gordon Research Conference
    Jeffrey Pollard; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  52. Hypoxia and the Role of HIF-1 in the Ischemic Testis
    Michael Palladino; Fiscal Year: 2005
    ..abstract_text> ..
  53. HERPES SIMPLEX VIRUS IMMUNE EVASION IN HIV SUBJECTS
    Harvey Friedman; Fiscal Year: 2005
    ..Preventing viral stealth may greatly improve antibody and C activities in HIV subjects, and may offer a novel strategy for developing HSV and other viral vaccines. ..
  54. ANTIGENS OF STREPTOCOCCUS MUTANS IN CARIES IMMUNITY
    Michael Russell; Fiscal Year: 2008
    ..p RESEARCHGRANT TABLE OF CONTENTS Page Numbers Face Page ................................................................................................................................................ 1 Description, ..
  55. Effect of Microbicides on Mucosal HIV Transmission
    Christopher Miller; Fiscal Year: 2004
    ..Further, these studies will determine if individuals that consistently and correctly use of microbicides in the face of repeated viral exposure develop anti-viral immune responses or local infection. ..
  56. The Role of Vsca1 in Erectile Function
    Kelvin P Davies; Fiscal Year: 2010
    ..Vcsal/hSMR3A expression might also be used as a non-subjective marker of erectile function. ..
  57. Tumor Invasion and Metastasis Mediated by Cell Surface Proteolysis
    Michael J Wilson; Fiscal Year: 2010
    ..Accomplishment of these aims may empower the design of a new generation of MMP inhibitors targeting the tumor cell surface and provide model systems to test the efficacies of these potential therapeutics. ..
  58. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2002
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  59. PHYSIOLOGY OF PUBERTY AND ANTISOCIAL BEHAVIOR
    Elizabeth Susman; Fiscal Year: 2003
    ..The study will fill a major void in the literature as it aims to assess both the effect of hormones on behavior and the neurobiological effect of antisocial behavior on hormone concentrations. ..
  60. TOXICOLOGY FOR TEACHERS
    Ann de Peyster; Fiscal Year: 2003
    ..These workshops are an innovative way for scientists and teachers to work together to improve science education. ..
  61. Differential Regulation of GnRH Gene Expression
    Helen Kim; Fiscal Year: 2005
    ..abstract_text> ..
  62. Regulation of Slo Splicing in the Urogenital Systme
    Kelvin Davies; Fiscal Year: 2006
    ..This research project will allow Dr. Davies to develop a thorough understanding of urogenital physiology, while at the same time allowing him to utilize his experience in molecular biology. ..
  63. EVOLUTIONARY GENETICS OF MALE REPRODUCTIVE TRAITS IN MUS
    MATTHEW DEAN; Fiscal Year: 2006
    ..These studies will help uncover the genetic basis of male reproductive fitness in a natural population of house mice. [unreadable] [unreadable]..
  64. Vcsa1 (hSMR3A) as a Marker for Diabetes
    Kelvin Davies; Fiscal Year: 2008
    ..The final aim will be to determine expression levels of hSMR3A protein from diabetic and non-diabetic patients (in saliva, blood and corporal samples) as an indicator of vascular health. [unreadable] [unreadable] [unreadable]..