corpus luteum

Summary

Summary: The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.

Top Publications

  1. ncbi Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum
    Takuo Hojo
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 56:515-9. 2010
  2. ncbi Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle
    Ryosuke Sakumoto
    Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305 8602, Japan
    Domest Anim Endocrinol 31:246-57. 2006
  3. ncbi The molecular control of corpus luteum formation, function, and regression
    Carlos Stocco
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06510, USA
    Endocr Rev 28:117-49. 2007
  4. pmc Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice
    Motoyuki Otsuka
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 118:1944-54. 2008
  5. ncbi Is FAS/Fas ligand system involved in equine corpus luteum functional regression?
    Antonio M Galvao
    C I I S A, Faculty of Veterinary Medicine, Technical University of Lisbon, Lisbon, Portugal
    Biol Reprod 83:901-8. 2010
  6. pmc Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase
    Edward Arvisais
    Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Mol Endocrinol 24:632-43. 2010
  7. ncbi Microvascularization and angiogenic activity of equine corpora lutea throughout the estrous cycle
    G Ferreira-Dias
    CIISA, Faculdade de Medicina Veterinaria, R Prof Cid dos Santos, 1300 477 Lisboa, Portugal
    Domest Anim Endocrinol 30:247-59. 2006
  8. ncbi Effect of prostaglandin F2 alpha on local luteotropic and angiogenic factors during induced functional luteolysis in the bovine corpus luteum
    Bajram Berisha
    Physiology Weihenstephan, Technical University Munich, Freising, Germany
    Biol Reprod 82:940-7. 2010
  9. ncbi Molecular control of luteal secretion of progesterone
    Gordon D Niswender
    Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, CO 80523 1683, USA
    Reproduction 123:333-9. 2002
  10. ncbi Possible involvement of IFNT in lymphangiogenesis in the corpus luteum during the maternal recognition period in the cow
    Akane Nitta
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Reproduction 142:879-92. 2011

Detail Information

Publications336 found, 100 shown here

  1. ncbi Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum
    Takuo Hojo
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 56:515-9. 2010
    The corpus luteum (CL) is mainly composed of luteal steroidogenic cells (LSCs) and luteal endothelial cells (LECs). Cell death of LSCs and LECs is essential for structural luteolysis...
  2. ncbi Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle
    Ryosuke Sakumoto
    Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305 8602, Japan
    Domest Anim Endocrinol 31:246-57. 2006
    There is increasing evidence that inflammatory cytokines regulate corpus luteum (CL) function in many species...
  3. ncbi The molecular control of corpus luteum formation, function, and regression
    Carlos Stocco
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06510, USA
    Endocr Rev 28:117-49. 2007
    The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of another organ and whose function and survival are limited in scope and time...
  4. pmc Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice
    Motoyuki Otsuka
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 118:1944-54. 2008
    ..This defect in female Dicer(d/d) mice was caused by corpus luteum (CL) insufficiency and resulted, at least in part, from the impaired growth of new capillary vessels in the ..
  5. ncbi Is FAS/Fas ligand system involved in equine corpus luteum functional regression?
    Antonio M Galvao
    C I I S A, Faculty of Veterinary Medicine, Technical University of Lisbon, Lisbon, Portugal
    Biol Reprod 83:901-8. 2010
    ..of the present work was to determine (i) the presence of the cytokine FASL and its receptor FAS in the mare's corpus luteum (CL) throughout the luteal phase, as well as (ii) the influence of FASL alone, or together with the cytokines ..
  6. pmc Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase
    Edward Arvisais
    Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Mol Endocrinol 24:632-43. 2010
    Little is known about the early intracellular events that contribute to corpus luteum regression...
  7. ncbi Microvascularization and angiogenic activity of equine corpora lutea throughout the estrous cycle
    G Ferreira-Dias
    CIISA, Faculdade de Medicina Veterinaria, R Prof Cid dos Santos, 1300 477 Lisboa, Portugal
    Domest Anim Endocrinol 30:247-59. 2006
    b>Corpus luteum growth and endocrine function are closely dependent on the formation of new capillaries...
  8. ncbi Effect of prostaglandin F2 alpha on local luteotropic and angiogenic factors during induced functional luteolysis in the bovine corpus luteum
    Bajram Berisha
    Physiology Weihenstephan, Technical University Munich, Freising, Germany
    Biol Reprod 82:940-7. 2010
    The essential role of endometrial prostaglandin F2 alpha (PTGF) for induction of the corpus luteum (CL) regression is well documented in the cow...
  9. ncbi Molecular control of luteal secretion of progesterone
    Gordon D Niswender
    Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, CO 80523 1683, USA
    Reproduction 123:333-9. 2002
    ..A model is presented for the proposed interactions of StAR, PBR and endozepine in the transport of cholesterol from the outer to the inner mitochondrial membrane...
  10. ncbi Possible involvement of IFNT in lymphangiogenesis in the corpus luteum during the maternal recognition period in the cow
    Akane Nitta
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Reproduction 142:879-92. 2011
    The corpus luteum (CL), which secretes large amounts of progesterone and is thus essential for establishing pregnancy, contains various types of immune cells that may play essential roles in CL function by generating immune responses...
  11. ncbi Prostaglandin F2alpha increases endothelial nitric oxide synthase in the periphery of the bovine corpus luteum: the possible regulation of blood flow at an early stage of luteolysis
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Reproduction 135:527-39. 2008
    ..causes alterations in luteal blood flow, reduces progesterone secretion, and induces luteolysis in the bovine corpus luteum (CL)...
  12. ncbi Effects of lysophopatidic acid on tumor necrosis factor α and interferon γ action in the bovine corpus luteum
    Izabela Woclawek-Potocka
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Mol Cell Endocrinol 377:103-11. 2013
    ..In conclusion our results indicate that LPA supports P4 synthesis and action in the bovine CL...
  13. ncbi Lysophosphatidic acid action in the bovine corpus luteum -an in vitro study
    Ilona Kowalczyk-Zieba
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 747 Olsztyn, Poland
    J Reprod Dev 58:661-71. 2012
    ..The stimulatory effect of LPA on P4 synthesis via 3βHSD stimulation and LPA-dependent stimulation of IFNτ action on OAS1 and ISG15 expression suggest that LPA is an additional auxiliary luteosupportive factor in steroidogenic cells...
  14. pmc Genome-wide gene expression analysis reveals a dynamic interplay between luteotropic and luteolytic factors in the regulation of corpus luteum function in the bonnet monkey (Macaca radiata)
    S Priyanka
    Department of Molecular Reproduction, Indian Institute of Science, Bangalore, India
    Endocrinology 150:1473-84. 2009
    Although LH is essential for survival and function of the corpus luteum (CL) in higher primates, luteolysis occurs during nonfertile cycles without a discernible decrease in circulating LH levels...
  15. ncbi Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade
    Raul Gomez
    Fundación IVI para el Estudio de la Reproducción, Valencia, Spain
    Endocrinology 143:4339-48. 2002
    ..zona pellucida of preovulatory and atretic follicles and in granulosa-lutein and endothelial cells of whole corpus luteum. A specific VEGF receptor-2 inhibitor (SU5416) was administered in three different protocols: on a daily basis,..
  16. ncbi SRB Reproduction, Fertility and Development Award Lecture 2008. Regulation and manipulation of angiogenesis in the ovary and endometrium
    Hamish M Fraser
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen s Institute of Medical Research, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Reprod Fertil Dev 21:377-92. 2009
    The marked cyclical physiological angiogenesis in the developing follicle, corpus luteum and endometrium implies a critical role in health and disease...
  17. pmc Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis
    Frank Kuhnert
    Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:10185-90. 2008
    ..in vitro against PDGF-BB and in vivo with near-complete blockade of pericyte recruitment in the angiogenic corpus luteum, resulting in prominent hemorrhage, thus demonstrating an essential function for PDGF signaling during ovarian ..
  18. ncbi Survival role of locally produced acetylcholine in the bovine corpus luteum
    M Omar Al-Zi'abi
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    Biol Reprod 80:823-32. 2009
    The present study was conducted to explore the source of acetylcholine (ACH) in the corpus luteum (CL) and to test our hypothesis of an antiapoptotic role of ACH in the bovine CL and, further, to investigate whether nerve growth factor (..
  19. ncbi Angiogenesis in the corpus luteum
    L P Reynolds
    Department of Animal and Range Sciences, and Cell Biology Center, Biotechnology Institute, North Dakota State University, Fargo 58105 5727, USA
    Endocrine 12:1-9. 2000
    The ovarian corpus luteum plays a critical role in reproduction because it is the primary source of circulating progesterone...
  20. ncbi Up-regulation of expression of interferon-stimulated gene 15 in the bovine corpus luteum during early pregnancy
    L Yang
    College of Animal Science and State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China
    J Dairy Sci 93:1000-11. 2010
    ..by conceptus trophectoderm cells and induces expression of IFN-stimulated gene 15 (ISG15) in the uterus and corpus luteum (CL) in ewes...
  21. ncbi Vascular and immune regulation of corpus luteum development, maintenance, and regression in the cow
    K Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Domest Anim Endocrinol 43:198-211. 2012
    The bovine corpus luteum (CL) is a unique, transient organ with well-coordinated mechanisms by which its development, maintenance, and regression are effectively controlled...
  22. ncbi Vascular composition, apoptosis, and expression of angiogenic factors in the corpus luteum during prostaglandin F2alpha-induced regression in sheep
    Kimberly A Vonnahme
    Department of Animal and Range Sciences, North Dakota State University, Fargo, 58105, USA
    Reproduction 131:1115-26. 2006
    ..vascular cell and fibroblast composition, apoptosis and mRNA expression for several angiogenic factors in the corpus luteum (CL) were determined...
  23. ncbi Rescue of corpus luteum function with peri-ovulatory HCG supplementation in IVF/ICSI GnRH antagonist cycles in which ovulation was triggered with a GnRH agonist: a pilot study
    P Humaidan
    The Fertility Clinic, Viborg Hospital Skive, DK 7800 Skive, Denmark
    Reprod Biomed Online 13:173-8. 2006
    ..Triggering of ovulation with GnRHa supplemented with 1500 IU HCG 35 h later (group 3) seems to secure a normal luteal phase and a normal clinical pregnancy outcome...
  24. ncbi Species-related differences in the mechanism of apoptosis during structural luteolysis
    Norihiro Sugino
    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Reprod Dev 53:977-86. 2007
    ..After the corpus luteum ceases to produce progesterone, it decreases in size, experiences a loss of cellular integrity, and then ..
  25. ncbi Progesterone stimulation by LH involves the phospholipase-C pathway in bovine luteal cells
    Ryo Nishimura
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 50:257-61. 2004
    ..These results support the hypothesis that the luteotropic action of LH in bovine luteal cells is mediated not only by activation of adenylate cyclase but also by activation of PLC...
  26. pmc Evidence that polymorphonuclear neutrophils infiltrate into the developing corpus luteum and promote angiogenesis with interleukin-8 in the cow
    Sineenard Jiemtaweeboon
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Reprod Biol Endocrinol 9:79. 2011
    After ovulation in the cow, the corpus luteum (CL) rapidly develops within a few days with angiogenesis and progesterone production. CL formation resembles an inflammatory response due to the influx of immune cells...
  27. ncbi Plasma progesterone concentrations in the mid-luteal phase are dependent on luteal size, but independent of luteal blood flow and gene expression in lactating dairy cows
    J Lüttgenau
    Clinic for Cattle, University of Veterinary Medicine Hannover Foundation, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Anim Reprod Sci 125:20-9. 2011
    ..Results indicate that plasma P(4) concentrations in the mid-luteal phase were dependent on luteal size, but independent of blood flow and gene expression per luteal tissue unit...
  28. ncbi Expression of leptin and its receptor in corpus luteum during estrous cycle in buffalo (Bubalus bubalis)
    Lalit Kumar
    Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
    Anim Reprod Sci 135:8-17. 2012
    ..The present study was aimed to investigate the importance of leptin and its receptors in buffalo corpus luteum (CL) obtained from different stages of the estrous cycle...
  29. ncbi Comparison between lactating and non-lactating dairy cows on follicular growth and corpus luteum development, and endocrine patterns of ovarian steroids and luteinizing hormone in the estrous cycles
    Natsumi Endo
    Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Anim Reprod Sci 134:112-8. 2012
    The dynamics of ovarian follicle, corpus luteum (CL), and peripheral plasma ovarian steroids were compared between lactating and non-lactating cows, and a possible association of pulsatile luteinizing hormone (LH) secretion with the ..
  30. ncbi Prostaglandin F2alpha-mediated activation of apoptotic signaling cascades in the corpus luteum during apoptosis: involvement of caspase-activated DNase
    Vijay K Yadav
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560 012, India
    J Biol Chem 280:10357-67. 2005
    ..F(2alpha) (PGF(2alpha)) acting via a G protein-coupled receptor has been shown to induce apoptosis in the corpus luteum of many species...
  31. ncbi Influence of season on corpus luteum structure and function and AI outcome in the Italian Mediterranean buffalo (Bubalus bubalis)
    S Di Francesco
    DISCIZIA, Faculty of Veterinary Medicine, Federico II University, Naples, Italy
    Theriogenology 78:1839-45. 2012
    The aim was to ascertain whether relationships between corpus luteum (CL) vascularization, CL function, and pregnancy outcome in AI in buffaloes were consistent across the breeding season and transition period to the nonbreeding season ..
  32. ncbi Nitric oxide stimulates progesterone and prostaglandin E2 secretion as well as angiogenic activity in the equine corpus luteum
    G Ferreira-Dias
    CIISA, Faculdade de Medicina Veterinaria, TULisbon, 1300 477 Lisbon, Portugal
    Domest Anim Endocrinol 40:1-9. 2011
    ..Furthermore, in mares, NO may play a role in CL growth during early luteal development, when vascular development is more intense...
  33. ncbi Leptin in the bovine corpus luteum: receptor expression and effects on progesterone production
    L T Nicklin
    School of Biosciences, The University of Nottingham, Sutton Bonington, United Kingdom
    Mol Reprod Dev 74:724-9. 2007
    ..This study was conducted to determine if the leptin receptor (OB-R) is expressed in the bovine corpus luteum (CL), and to examine the effects of leptin on progesterone production by dispersed luteal cells in vitro...
  34. ncbi Angiogenesis and vascular endothelial growth factor expression in the equine corpus luteum
    M O Al-Zi'abi
    Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Reproduction 125:259-70. 2003
    Precise pharmacological control of the corpus luteum is important in the manipulation of the oestrous cycle in mares...
  35. ncbi Temporal gene expression in equine corpora lutea based on serial biopsies in vivo
    T L Slough
    Colorado State University, Animal Reproduction and Biotechnology Laboratory, Fort Collins 80523, USA
    J Anim Sci 89:389-96. 2011
    A biopsy procedure was developed to enable repeated sampling of a single equine corpus luteum (CL) over the course of an estrous cycle...
  36. ncbi Cytokines tumor necrosis factor-α and interferon-γ participate in modulation of the equine corpus luteum as autocrine and paracrine factors
    A Galvao
    CIISA, Technical University of Lisbon, Portugal
    J Reprod Immunol 93:28-37. 2012
    Knowledge on the regulation of corpus luteum (CL) function in the mare is scarce...
  37. ncbi Luteal angiogenesis: prevention and intervention by treatment with vascular endothelial growth factor trap(A40)
    C Wulff
    Medical Research Council Human Reproductive Sciences Unit, Edinburgh, Scotland, United Kingdom EH3 9ET
    J Clin Endocrinol Metab 86:3377-86. 2001
    ..Luteal Flt mRNA expression is dependent upon VEGF, and VEGF inhibition results in abortive increases in expression of VEGF, angiopoietin-2, and Tie-2...
  38. ncbi Ovarian function in ruminants
    B Berisha
    Department of Physiology, Technical University Munich Weihenstephan, Weihenstephaner Berg 3, D 85354 Freising, Germany
    Domest Anim Endocrinol 29:305-17. 2005
    ..to highlight important steps of ovarian regulation during follicle development, ovulation and the life span of corpus luteum (CL) in ruminants. The ovarian cycle is central to reproductive function...
  39. ncbi Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the follicle and corpus luteum
    W Colin Duncan
    Obstetrics and Gynaecology, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, United Kingdom
    Endocrinology 149:3313-20. 2008
    Vascular endothelial growth factor (VEGF)-dependent angiogenesis is crucial for follicular growth, and corpus luteum formation and function, in the primate ovary...
  40. ncbi Local regulation of corpus luteum development and regression in the cow: Impact of angiogenic and vasoactive factors
    A Miyamoto
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Domest Anim Endocrinol 37:159-69. 2009
    The corpus luteum (CL) of the estrous cycle in the cow is a dynamic organ which has a life time of approximately 17-18 days...
  41. ncbi Inhibition of early luteal angiogenesis by gonadotropin-releasing hormone antagonist treatment in the primate
    S E Dickson
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 85:2339-44. 2000
    ..on the early luteal phase angiogenesis peak; and 3) describe the resultant morphological changes in the corpus luteum (CL)...
  42. ncbi Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis
    Rachel E Dickinson
    Department of Reproductive and DevelopmentalSciences, Division of Obstetrics and Gynaecology, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Endocrinology 150:2873-81. 2009
    ..Overall, these results imply expression of LHR splice variants is regulated in the human CL. Furthermore, during functional luteolysis a truncated variant could modulate the cell surface expression and activity of full-length LHR...
  43. ncbi Regulation of corpus luteum function in cattle--an overview
    D Schams
    Department of Physiology, Technical University Munich Weihenstephan, Weihenstephaner Berg 3, D 85350 Freising, Germany
    Reprod Domest Anim 39:241-51. 2004
    The corpus luteum (CL) is a transient reproductive gland that produces progesterone (P), required for the establishment and maintenance of pregnancy...
  44. ncbi Apoptosis-associated gene expression in the corpus luteum of the rat
    K Guo
    Department of Clinical Research, University of Berne, Switzerland
    Biol Reprod 58:739-46. 1998
    The involution of the corpus luteum (CL) at parturition is an example of physiological apoptosis, a complex process involving massive vascular regression while luteal cells undergo apoptosis...
  45. pmc Effects of deletion of the prolactin receptor on ovarian gene expression
    Isabelle Grosdemouge
    Molecular Endocrinology, INSERM U344 Faculté de Médecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    Reprod Biol Endocrinol 1:12. 2003
    ..The present study demonstrates that the ovulation rate is not different between PRLR+/+ and PRLR-/- mice. The corpus luteum is formed but an elevated level of apoptosis and extensive inhibition of angiogenesis occur during the luteal ..
  46. ncbi Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene
    Tenghe Ma
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun, China
    J Appl Genet 52:481-6. 2011
    ..Recent studies indicated that miRNAs are mechanistically involved in the regulation of the mammalian corpus luteum (CL)...
  47. ncbi A quantitative study of changes in the human corpus luteum microvasculature during the menstrual cycle
    F Gaytan
    Department of Cell Biology, Faculty of Medicine, University of Cordoba
    Biol Reprod 60:914-9. 1999
    Endothelial cells are the most abundant cell type in the corpus luteum (CL), and changes in blood vessels have been proposed to play a pivotal role in CL regression...
  48. ncbi Corpus luteum (CL) function: local control mechanisms
    R Webb
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics LE12 5RD, UK
    Domest Anim Endocrinol 23:277-85. 2002
    ..In conclusion locally produced factors are important in the control of luteal function, although their roles have yet to fully elucidated...
  49. ncbi Select nutrients in the ovine uterine lumen. IV. Expression of neutral and acidic amino acid transporters in ovine uteri and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:1196-208. 2009
    ..These results document coordinate changes in expression of transporters that are likely responsible for increases in amounts of neutral and acidic amino acids in the uterine lumen to support conceptus growth, development, and survival...
  50. ncbi Dynamic changes in mitogen-activated protein kinase (MAPK) activities in the corpus luteum of the bonnet monkey (Macaca radiata) during development, induced luteolysis, and simulated early pregnancy: a role for p38 MAPK in the regulation of luteal functio
    V K Yadav
    Department of Molecular Reproduction, Development, and Genetics, Indian Institute of Science, Bangalore
    Endocrinology 147:2018-27. 2006
    Changes in MAPK activities were examined in the corpus luteum (CL) during luteolysis and pregnancy, employing GnRH antagonist (Cetrorelix)-induced luteolysis, stages of CL, and hCG treatment to mimic early pregnancy as model systems in ..
  51. ncbi Control of human luteal steroidogenesis
    Luigi Devoto
    Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Instituto de Investigaciones Materno Infantil, IDIMI y Universidad de Chile, PO Box 226 3, Santiago, Chile
    Mol Cell Endocrinol 186:137-41. 2002
    The human corpus luteum (CL) undergoes a dynamic cycle of differentiation, steroid hormone production and regression during the course of non-fertile cycles...
  52. ncbi Endothelins enhance prostaglandin (PGE(2) and PGF(2alpha)) biosynthesis and release by human luteal cells: evidence of a new paracrine/autocrine regulation of luteal function
    F Miceli
    Department of Obstetrics and Gynecology, , 00168 Rome, Italy
    J Clin Endocrinol Metab 86:811-7. 2001
    ..As PGs are deeply involved in corpus luteum activity, and ETs were also able to influence progesterone production, the present new data suggest an ..
  53. ncbi Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression
    C T Albarracin
    Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612
    Endocrinology 134:2453-60. 1994
    ..15 (37K) is expressed specifically in the corpus luteum and is markedly inhibited by PRL...
  54. ncbi The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle
    Sabine Erdmann
    Institute of Anatomy, University of Leipzig, Liebigstr 13, 04103, Leipzig, Germany
    Am J Physiol Endocrinol Metab 293:E1365-77. 2007
    In the corpus luteum (CL), blood vessels develop, stabilize, and regress. This process depends on the ratio of pro- and antiangiogenic factors, which change during the ovarian cycle...
  55. ncbi Angiogenesis in the human corpus luteum: changes in expression of angiopoietins in the corpus luteum throughout the menstrual cycle and in early pregnancy
    Norihiro Sugino
    Division of Obstetrics and Gynecology, Department of Reproductive, Pediatric and Infectious Science, Yamaguchi University School of Medicine, Minamikogushi 1 1 1, Ube 755 8505, Japan
    J Clin Endocrinol Metab 90:6141-8. 2005
    Blood vessel stabilization is regulated by angiopoietins and important for angiogenesis in the corpus luteum.
  56. ncbi Involvement of pro-inflammatory cytokines, mediators of inflammation, and basic fibroblast growth factor in prostaglandin F2alpha-induced luteolysis in bovine corpus luteum
    T P Neuvians
    Department of Physiology, Technical University Munich, Weihenstephaner Berg 3, D 85350 Freising Weihenstephan, Germany
    Biol Reprod 70:473-80. 2004
    ..basic fibroblast growth factor (FGF-2) during prostaglandin (PG) F(2alpha)-induced luteolysis in the bovine corpus luteum (CL)...
  57. ncbi Roles of tumor necrosis factor-alpha of the estrous cycle in cattle: an in vivo study
    Dariusz J Skarzynski
    Division of Reproductive Endocrinology and Pathophysiology, Institute of Animal Reproduction and Food Research, PAS, Olsztyn 10 747, Poland
    Biol Reprod 69:1907-13. 2003
    ..05). Altogether, the results suggest that low concentrations of TNFalpha cause luteolysis, whereas high concentrations of TNFalpha activate corpus luteum function and prolong the estrous cycle in cattle.
  58. pmc Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech Incorporated, South San Francisco, California 94080, USA
    Am J Pathol 162:1881-93. 2003
    ..Compelling evidence indicated that vascular endothelial growth factor (VEGF) is a key mediator of the cyclical corpus luteum angiogenesis...
  59. ncbi Local changes in blood flow within the early and midcycle corpus luteum after prostaglandin F(2 alpha) injection in the cow
    Tomas J Acosta
    Departamento de Fisiologia, Facultad de Ciencias Veterinarias, Universidad Nacional de Asuncion, San Lorenzo, Paraguay
    Biol Reprod 66:651-8. 2002
    ..However, before Day 5 of the normal cycle, the corpus luteum (CL) is refractory to the luteolytic action of PGF(2 alpha)...
  60. ncbi Immune cells in the corpus luteum: friends or foes?
    J L Pate
    Department of Animal Sciences, Ohio State University, OARDC, Wooster, OH 44691, USA
    Reproduction 122:665-76. 2001
    The corpus luteum produces progesterone, which is essential for the maintenance of pregnancy. In the absence of a viable embryo, the corpus luteum must regress rapidly to allow for development of new ovulatory follicles...
  61. ncbi Angiogenesis in developing follicle and corpus luteum
    C Tamanini
    Faculty of Veterinary Medicine, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzana Emilia, Bologna, Italy
    Reprod Domest Anim 39:206-16. 2004
    ..is essential to guarantee the necessary supply of nutrients and hormones to promote follicular growth and corpus luteum formation...
  62. ncbi Apoptosis during spontaneous and prostaglandin F(2alpha)-induced luteal regression in the buffalo cow (Bubalus bubalis): involvement of mitogen-activated protein kinases
    Vijay K Yadav
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
    Biol Reprod 67:752-9. 2002
    The present study was conducted to evaluate whether the corpus luteum (CL) of the water buffalo (Bubalus bubalis) cow undergoes luteal regression by the process of apoptosis and to examine the involvement of mitogen-activated protein (..
  63. ncbi Endothelin-1 mediates prostaglandin F(2alpha)-induced luteal regression in the ewe
    S T Hinckley
    Department of Animal Science, University of Connecticut, Storrs, Connecticut 06269-4040, USA
    Biol Reprod 64:1619-23. 2001
    ..These data complement and extend previously published reports in the bovine CL and are the strongest evidence presented to date in support of a role for ET-1 in PGF(2alpha)-mediated luteal function in domestic ruminants...
  64. ncbi Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse
    D S Inderdeo
    Department of Biochemistry, University of Western Ontario, London, Canada
    Biol Reprod 55:498-508. 1996
    ..In situ hybridization localized TIMP-1 mRNA to the corpus luteum at D18 and PP1, and to oocytes at specific stages of follicular development...
  65. ncbi Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary
    A L Durlinger
    Department of Endocrinology and Reproduction, Erasmus University Rotterdam, The Netherlands
    Endocrinology 140:5789-96. 1999
    ..The female AMH null mouse may thus provide a useful model to study regulation of primordial follicle recruitment and the relation between follicular dynamics and ovarian aging...
  66. ncbi Induction of endothelin-2 expression by luteinizing hormone and hypoxia: possible role in bovine corpus luteum formation
    Eyal Klipper
    Department of Animal Sciences, The Robert H Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Endocrinology 151:1914-22. 2010
    ..EDN2 mRNA was determined in corpus luteum (CL) and during folliculoluteal transition induced by GnRH in vivo...
  67. ncbi Expression of cyclooxygenase 1 and 2 in the canine corpus luteum during diestrus
    Mariusz Pawel Kowalewski
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University Giessen, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Theriogenology 66:1423-30. 2006
    In the dog, unlike most other domestic animal species, corpus luteum (CL) life span is not affected by hysterectomy...
  68. ncbi Effect of intraluteal injection of endothelin type A receptor antagonist on PGF2alpha-induced luteolysis in the cow
    Sho Watanabe
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan
    J Reprod Dev 52:551-9. 2006
    Endothelin-1 (ET-1) is a luteolytic mediator in the bovine corpus luteum (CL), and its action appears to be via endothelin type A receptor (ETR-A)...
  69. ncbi Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis
    V Goede
    Department of Gynecology and Obstetrics, University of Gottingen Medical School, Germany
    Lab Invest 78:1385-94. 1998
    Cyclic angiogenic processes in the ovarian corpus luteum (CL) of monovulatory species are characterized by distinct phases of blood vessel growth, vessel maturation, and vessel regression...
  70. ncbi Prostaglandin F2alpha differentially affects mRNA expression relating to angiogenesis, vasoactivation and prostaglandins in the early and mid corpus luteum in the cow
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    J Reprod Dev 56:428-36. 2010
    ..8-12 of the estrous cycle) drastically reduces the plasma progesterone concentrations and the volume of the corpus luteum (CL)...
  71. ncbi Characterization of the canine 3beta-hydroxysteroid dehydrogenase and its expression in the corpus luteum during diestrus
    M P Kowalewski
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, D 35392 Giessen, Germany
    J Steroid Biochem Mol Biol 101:254-62. 2006
    ..01) and immunhistochemistry may indicate that the provision of progesterone is controlled by availability of the enzyme rather than the substrate...
  72. ncbi Fas-Fas ligand system mediates luteal cell death in bovine corpus luteum
    Hiroaki Taniguchi
    Laboratory of Reproductive Endocrinology, Department of Animal Science, Faculty of Agriculture, Okayama University, Okayama 700 8530, Japan
    Biol Reprod 66:754-9. 2002
    ..The present study was undertaken to identify the presence of a Fas-Fas L system in bovine corpus luteum (CL) and to evaluate the regulation of Fas-mediated luteal cell death by leukocyte-derived cytokines...
  73. ncbi Hypoxia is important for establishing vascularization during corpus luteum formation in cattle
    Ryo Nishimura
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 56:110-6. 2010
    ..In the ovary, angiogenesis is known to occur after ovulation in the developing corpus luteum (CL) in mammals...
  74. ncbi Cell death during natural and induced luteal regression in mares
    M O Al-Zi'abi
    Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Reproduction 123:67-77. 2002
    ..Apoptosis did appear to be involved in luteolysis in the equine corpus luteum, but non-apoptotic changes were also observed in some luteal cells during regression...
  75. ncbi Lysophosphatidic acid up-regulates expression of interleukin-8 and -6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome
    Shee Uan Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan
    J Clin Endocrinol Metab 93:935-43. 2008
    ..Angiogenic cytokines, including IL-6, IL-8, and vascular endothelial growth factor, increased in plasma and ascites of patients with ovarian hyperstimulation syndrome. The role of LPA in ovarian follicles is unclear...
  76. ncbi The yin and yang of corpus luteum-derived endothelial cells: balancing life and death
    Rina Meidan
    Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Domest Anim Endocrinol 29:318-28. 2005
    A dense network of capillaries irrigates the corpus luteum (CL) allowing an intricate cross talk between luteal steroiodgenic and endothelial cell (EC) types...
  77. ncbi Alternative splicing of the human luteal LH receptor during luteolysis and maternal recognition of pregnancy
    Mayank Madhra
    Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, University of Edinburgh, UK
    Mol Hum Reprod 10:599-603. 2004
    ..These data do not support the hypothesis that qualitative changes in LH receptor splicing have a role in luteolysis or that a naturally occurring LH receptor lacking exon 10 has a role in maternal recognition of pregnancy...
  78. ncbi The influence of tumor necrosis factor alpha (TNF) on the secretory function of bovine corpus luteum: TNF and its receptors expression during the estrous cycle
    Anna Korzekwa
    Department of Reproductive Immunology, Institute of Animal Reproduction and Food Research, Olsztyn, Poland
    Reprod Biol 8:245-62. 2008
    Tumor necrosis factor alpha (TNF) inversely regulates the function of bovine corpus luteum (CL). Whereas the low doses of TNF induce luteolysis, the high doses prolong CL lifespan and prevent luteolysis in vivo...
  79. ncbi Regulation and action of angiogenic factors in the primate ovary
    R L Stouffer
    Division of Reproductive Sciences, Oregon Regional Primate Research Center Oregon Health Sciences University, Beaverton, OR 97006, USA
    Arch Med Res 32:567-75. 2001
    The ephemerality of the maturing follicle and subsequent corpus luteum as they perform their gametogenic and/or endocrine functions during the ovarian cycle is associated with remarkable changes in local vasculature...
  80. ncbi Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation
    Marina A Vorontchikhina
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA
    Gene Expr Patterns 5:701-9. 2005
    ..the expression patterns of Notch1, Notch4, and Jagged1 proteins during the process of folliculogenesis and corpus luteum formation in the mouse ovary, an organ with dynamic physiological angiogenic growth...
  81. ncbi Effects of luteinizing hormone and human chorionic gonadotropin on corpus luteum cells in a spheroid cell culture system
    A Walz
    Department of Obstetrics and Gynecology, University Medical School Freiburg, Freiburg, Germany
    Mol Reprod Dev 72:98-104. 2005
    The human corpus luteum (CL) is a highly vascularized, temporarily active endocrine gland and consists mainly of granulosa cells (GCs), theca cells (TCs), and endothelial cells (ECs)...
  82. ncbi Human corpus luteum physiology and the luteal-phase dysfunction associated with ovarian stimulation
    Luigi Devoto
    Universidad de Chile, Hospital Clinico San Borja Arriaran, Santiago, Chile
    Reprod Biomed Online 18:19-24. 2009
    The human corpus luteum is a temporary endocrine gland that develops after ovulation from the ruptured follicle during the luteal phase...
  83. ncbi Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C
    A Herrlich
    Institut fur Pharmakologie, Freie Universitat Berlin, Thielallee 69 73, D 14195 Berlin, Germany
    J Biol Chem 271:16764-72. 1996
    ..Thus, the LH receptor couples to both Gs and Gi, and betagamma-subunits released from either G protein contribute to the stimulation of phospholipase C-beta isoforms...
  84. ncbi Microvascular endothelial cells differ in basal and hypoxia-regulated expression of angiogenic factors and their receptors
    Gerelsul Tscheudschilsuren
    Institute of Anatomy, Institute of Pharmacy, University of Leipzig, Liebigstrasse 13, Germany
    Microvasc Res 63:243-51. 2002
    ..and functionally different types of microvascular endothelial cells (MVECs) derived from the developing corpus luteum were isolated and characterized by our group...
  85. ncbi Comparison of the effect of ovulation-inducing factor (OIF) in the seminal plasma of llamas, alpacas, and bulls
    Marcelo H Ratto
    Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, Canada S7N 5B4
    Theriogenology 66:1102-6. 2006
    ..Ovulation and maximum corpus luteum diameter were compared by ultrasonography among female llamas (n=19 per group) treated intramuscularly with 2 ..
  86. ncbi High expression of bovine alpha glutathione S-transferase (GSTA1, GSTA2) subunits is mainly associated with steroidogenically active cells and regulated by gonadotropins in bovine ovarian follicles
    F Rabahi
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Endocrinology 140:3507-17. 1999
    ..2 kb and 1.4 kb, respectively for bGSTA1 and bGSTA2. The messenger RNA (mRNA) were detected in GC, corpus luteum, adrenal gland, testis, liver, lung, thyroid, kidney and cotyledon, and the relative abundance of their mRNA ..
  87. ncbi Blood flow: a key regulatory component of corpus luteum function in the cow
    A Miyamoto
    Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080 8555 Obihiro, Japan
    Domest Anim Endocrinol 29:329-39. 2005
    Prostaglandin F2alpha (PGF2alpha) is the primary luteolysin in the cow. During the early luteal phase, the corpus luteum (CL) is resistant to the luteolytic effect of PGF2alpha...
  88. ncbi Inverse relationship between nitric oxide synthases and endothelin-1 synthesis in bovine corpus luteum: interactions at the level of luteal endothelial cell
    Maya Rosiansky-Sultan
    Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Endocrinology 147:5228-35. 2006
    Endothelin-1 (ET-1) and nitric oxide (NO) play pivotal roles in corpus luteum (CL) function. The present study examined the interplay between NO and ET-1 synthesis in the bovine CL...
  89. ncbi Sequence of interleukin 1beta actions on corpus luteum regression: relationship with inducible cyclooxygenase and nitric oxide synthase expression
    A Estevez
    Centro de Estudios Farmacológicos y Botánicos Consejo de Investigaciones Científicas y Técnicas, Serrano 669 CP 1414, Buenos Aires, Argentina
    Reproduction 126:639-45. 2003
    b>Corpus luteum regression has been described in terms of: (i) functional luteolysis - a reversible decline in serum progesterone concentration; and (ii) structural luteolysis - irreversible morphological changes and tissue remodelling ..
  90. ncbi Distribution of arteriolovenous vessels, capillaries and eNOS expression in the bovine corpus luteum during the estrous cycle: a possible implication of different sensitivity by luteal phase to PGF(2alpha) in the increase of luteal blood flow
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan
    J Reprod Dev 56:124-30. 2010
    We have shown that luteal blood flow increases in the peripheral vasculature of the mature corpus luteum (CL) prior to the onset of luteolysis in response to prostaglandin F(2alpha) (PGF(2alpha)) in the cow, but this phenomenon does not ..
  91. ncbi Analysis of luteal tissue inhibitor of metalloproteinase-1, -2, and -3 during prostaglandin F(2alpha)-induced luteolysis
    William A Ricke
    Department of Animal Science, 160 Animal Science Center, University of Missouri, Columbia, MO 65211, USA
    Biol Reprod 66:1387-94. 2002
    ..This action may increase the MMP:TIMP-1 ratio, creating an environment that favors extracellular matrix degradation and, thereby, facilitates both functional and structural regression...
  92. ncbi Absence of corpus luteum rescue by chorionic gonadotropin in women immunized with a contraceptive vaccine
    R Pal
    Immunoendocrinology Laboratory, National Institute of Immunology, New Delhi, India
    Fertil Steril 76:332-6. 2001
    ..CONCLUSION(S): Antibodies elicited by a betahCG vaccine inactivate hCG and prevent the hormone from rescuing corpus luteum, resulting in progesterone fall and normal menses...
  93. ncbi Luteal blood flow is a more appropriate indicator for luteal function during the bovine estrous cycle than luteal size
    K Herzog
    Clinic for Cattle, University of Veterinary Medicine Hannover, Hannover, Germany
    Theriogenology 73:691-7. 2010
    ..Luteal size was determined by sonographic measurement of the maximal cross-sectional area of the corpus luteum (CL)...
  94. ncbi Angiogenesis in the corpus luteum of early pregnancy in the marmoset and the effects of vascular endothelial growth factor immunoneutralization on establishment of pregnancy
    Amanda J Rowe
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH3 9ET, United Kingdom
    Biol Reprod 67:1180-8. 2002
    This study investigated vascular and molecular changes in the corpus luteum (CL) of early pregnancy in the marmoset...
  95. ncbi The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast
    L S Tashima
    Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu 96822
    J Clin Endocrinol Metab 80:707-10. 1995
    ..However, we have detected hLey I-L gene expression in the cyclic human corpus luteum and trophoblast by the reverse transcriptase-polymerase chain reaction (RT-PCR), with primers selected from ..
  96. ncbi cAMP-dependent regulation of CYP19 gene in rabbit preovulatory granulosa cells and corpus luteum
    Thomas Andrieu
    Laboratoire, EA 2608, INRA, USC 2006, Universite, Esplanade de la Paix, F 14000 Caen, France
    J Steroid Biochem Mol Biol 116:110-7. 2009
    ....
  97. ncbi Role of apoptosis, apoptosis-related factors and 17beta-hydroxysteroid dehydrogenases in human corpus luteum regression
    Tommi E Vaskivuo
    Department of Obstetrics and Gynecology, University of Oulu, FIN 90014 Oulu, Finland
    Mol Cell Endocrinol 194:191-200. 2002
    The human corpus luteum (CL) is a transient endocrine organ with a life span of 14-16 days...
  98. ncbi Phytoestrogens and their metabolites inhibit the sensitivity of the bovine corpus luteum to luteotropic factors
    Katarzyna K Piotrowska
    Department of Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
    J Reprod Dev 52:33-41. 2006
    ..whether active metabolites of phytoestrogens (equol and para-ethyl-phenol) inhibit sensitivity of bovine corpus luteum (CL) to luteinizing hormone (LH) and to auto/paracrine luteotropic factors (prostaglandin E2-PGE2 and ..
  99. ncbi Role of nitric oxide in the regulation of superoxide dismutase and prostaglandin F(2alpha) production in bovine luteal endothelial cells
    Seunghyung Lee
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    J Reprod Dev 56:454-9. 2010
    ....
  100. ncbi Gonadotropin induction of ovulation and corpus luteum formation in young estrogen receptor-alpha knockout mice
    C S Rosenfeld
    Departments of Animal Sciences and Biochemistry and Child Health, University of Missouri at Columbia, Columbia, Missouri 65211, USA
    Biol Reprod 62:599-605. 2000
    ..On the basis of these findings, ovarian folliculogenesis, ovulation, and CL formation can occur in the absence of ERalpha, although to a lesser extent than in WT mice...
  101. ncbi Acute changes in circulating concentrations of progesterone and nitric oxide and partial pressure of oxygen during prostaglandin F2alpha-induced luteolysis in cattle
    Tomas Javier Acosta
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    J Reprod Dev 55:149-55. 2009
    ....

Research Grants65

  1. REGULATION OF THE CORPUS LUTEUM
    Anthony Zeleznik; Fiscal Year: 2003
    ..is to elucidate the physiological and cellular mechanisms responsible for the regression of the primate corpus luteum as well as to understand the mechanisms by which the lifespan of the corpus luteum is prolonged during early ..
  2. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..sheep as an experimental model to study mechanisms controlling the synthesis of progesterone (P4) by the corpus luteum (CL). During this experience, Dr...
  3. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    ..the role of these caspases in villous cytotrction of hCG to maintain production of progesterone by the corpus luteum early in pregnancy and transport of gasses, nutrients and maternal protective antibodies across the placenta, ..
  4. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    ..via locally synthesized steroids, regulates the structure-function of the peri-ovulatory follicle or corpus luteum (CL) in primates during the menstrual cycle...
  5. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..signaling in the primate ovary is a critical regulator of events necessary for ovulation and formation of the corpus luteum (assessed in Aim 1);as well as for C-OE, reinitiation of oocyte meiosis, fertilization, and early embryonic ..
  6. Role of mineralocorticoid receptor in primate ovarian function
    CHARLES CHAFFIN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The formation, function, and demise of the primate corpus luteum are critical aspects of menstrual cyclicity, infertility, and contraceptive intervention...
  7. REGULATION OF OVARIAN FUNCTION BY GONADOTROPIN
    JAIRAM K M MENON; Fiscal Year: 2013
    ..studies will examine the consequences of the deletion of LRBP (mevalonate kinase) gene on follicle growth, corpus luteum formation and function...
  8. Protease regulation of ovarian recrudescence
    KELLY ANSLEY YOUNG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ovarian function, including follicle development, ovulation, and corpus luteum formation/degradation, is dependent upon tissue remodeling events, many of which are associated with a family of Zn+..
  9. Vervet Monkey: Modeling Effects of Diet-Induced Obesity on Reproduction
    Alex Joel Polotsky; Fiscal Year: 2011
    ..To test the hypothesis that obesity causes corpus luteum insufficiency, differential gene profiling will be conducted on corpus luteum tissue removed by luteectomy...
  10. Use of a Fragile X premutation knock-in mouse to study FXPOI
    Joshua Johnson; Fiscal Year: 2013
    ..Aim 2 focuses on the abnormal FMRP, ubiquitin, and gap junctions as well as the abnormalities in zona pellucida composition to attempt to uncover the mechanism(s) responsible for the follicle decline. ..
  11. Regulation of Aromatase Expression in the Corpus Luteum
    CARLOS OSCAR STOCCO; Fiscal Year: 2012
    ..This suggests that alternative mechanisms control estradiol production in the corpus luteum. On the other hand, we have demonstrated that aromatase expression in corpora lutea of pregnant rats ..
  12. The role of Core Binding Factors (CBFs) in the periovulatory process
    Misung Jo; Fiscal Year: 2011
    ..maturation that culminates in ovulation of an expanded cumulus-oocyte complex (COC) and formation of the corpus luteum (CL)...
  13. MicroRNA Regulation of Ovarian Function
    Lane K Christenson; Fiscal Year: 2013
    ..Ovulation of a fertilizable oocyte and formation of a functional corpus luteum are absolute requirements for reproductive success and are induced by the mid-cycle surge of luteinizing ..
  14. The Role of Leptin in the Vascularization of the Developing Corpus Luteum
    MICHELLE R GARCIA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The corpus luteum (CL) is an ovarian structure responsible for the maintenance of pregnancy in mammalian species, via the production of the steroid hormone progesterone...
  15. Role of STARD6 in ovarian steroidogenesis
    HOLLY ANNE LAVOIE; Fiscal Year: 2013
    ..in the theca cell layer of the follicle prior to the luteinizing hormone (LH) surge and in the cells of the corpus luteum following the LH surge...
  16. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard L Stouffer; Fiscal Year: 2010
    ..the expression and action of angiopoietin (Ang) and endocrine gland (EG)-VEGF in the preovulatory follicle and corpus luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian ..
  17. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2013
    ..and reduce the large numbers of pregnancies that are lost because of inappropriate regression of the primate corpus luteum (CL) at the end of the menstrual cycle, and to contribute to better management of cardiovascular disease (CVD) ..
  18. Biology of the Primate Ovarian Surface Epithelium
    Jay W Wright; Fiscal Year: 2011
    ..e.the follicle destined to ovulate and the corpus luteum) and/or as a result of their exposure to the endocrine products of these structures (i.e...
  19. Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ART
    Kirk P Conrad; Fiscal Year: 2013
    ..begin in a state which is not physiological for the mother, secondary to the abnormal status of the corpus luteum and its production of relaxin or other hormones...
  20. Corpus luteum mechanical regulation in a tissue-engineered model of ovarian aging
    Robin M Skory; Fiscal Year: 2012
    ..to younger counterparts, older women have lower levels of luteal phase hormones, which are produced by the corpus luteum (CL). Unfortunately, the mechanism of age-related CL dysfunction is unknown...
  21. Hormone levels during pregnancy and maternal ovarian cancer
    Annekatrin Lukanova; Fiscal Year: 2010
    ..and Sweden, we will explore the associations between progesterone and 17alpha-OH progesterone (marker of corpus luteum function and correlate of ovarian synthesis of progesterone) in stored specimens obtained during the first ..
  22. OVULATION--STUDIES USING IN VITRO PERFUSED OVARIES
    Edward Wallach; Fiscal Year: 1992
    ..in the rabbit: 1) follicle wall disruption (ovulation); 2) oocyte maturation (nuclear and cytoplasmic); and 3) corpus luteum formation...
  23. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2004
    ..We will then test the hypothesis that this novel protocol, by preventing the hypersecretion of luteal products in gonadotropin-induced pregnancies, will result in safer infertility therapy. ..
  24. CONTROL OF CORPUS LUTEUM FUNCTION
    John Gadsby; Fiscal Year: 1990
    ..the production of an unidentified "placental luteotrophin" (PL), plays an important role in the maintenance of corpus luteum function in the pregnant rabbit...
  25. MEMBRANE EVENTS FOLLOWING HORMONE BINDING TO LH RECEPTOR
    DEBORAH ROESS; Fiscal Year: 1991
    ..hormone (LH) and human chorionic gonadotropin (hCG) regulate the secretion of progesterone from the corpus luteum during the menstrual cycle and early pregnancy...
  26. GAP JUNCTIONS AND LUTEAL FUNCTION
    ANNA GRAZUL BILSKA; Fiscal Year: 1999
    ..Elucidation of contact-dependent mechanisms that regulate cellular interactions will provide insight into the coordination of cellular processes during luteal growth, differentiation and regression. ..
  27. REGULATION OF ENDOMETRIAL PROSTAGLANDIN F-2A SECRETION
    MARK MIRANDO; Fiscal Year: 1999
    ..e. PGF 2alpha) is necessary for establishment of pregnancy and is also responsible for corpus luteum regression...
  28. Transcription Factors in Trophectoderm Differentiation
    Robert Roberts; Fiscal Year: 2007
    The early production of human chorionic gonadotropin (hCG) by the trophoblast is essential to rescuing the corpus luteum and maintaining production of progesterone in early pregnancy...
  29. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    Relaxin is a heterodimeric peptide hormone produced by the corpus luteum, decidua, and placenta in pregnant and nonpregnant females attaining the highest plasma levels during pregnancy...
  30. PROSTAGLANDIN RECEPTOR REGULATION IN THE CORPUS LUTEUM
    Milo Wiltbank; Fiscal Year: 2000
    ..pathways, thus, establishing the cellular mechanisms for ovulation, luteinization, and regression of the corpus luteum. The Specific Aims are: 1) Characterize the temporal pattern for the in vivo expression of PGF/2alpha ..
  31. MONOCYTE CHEMOATTRACTANT PROTEIN 1 IN THE CORPUS LUTEUM
    PAUL KEYES; Fiscal Year: 1999
    One of the most remarkable features about the corpus luteum is that it is a transient gland: in the absence of conception, the corpus luteum disappears from the surface of the ovary at the end of each menstrual or estrous cycle...
  32. IN VIVO REGULATION OF STAR IN THE HUMAN CORPUS LUTEUM
    JEROME STRAUSS; Fiscal Year: 2003
    The synthesis of progesterone by the corpus luteum is required for the establishment of human pregnancy...
  33. PDE3 Inhibitors: Selective Blockers of Oocyte Maturation
    Jeffrey Jensen; Fiscal Year: 2007
    ..2) Determine if PDE3 inhibitors prevent oocyte maturation, but not ovulation and function of the corpus luteum in rhesus monkeys undergoing controlled ovarian stimulation (COS) protocols or during natural cycles in vivo...
  34. OVARIAN LDL RECEPTOR AND STAR GENE REGULATION
    HOLLY LAVOIE; Fiscal Year: 2003
    ..development of one or more follicles to the pre-ovulatory stage, and formation and maintenance of a functional corpus luteum. During these transitions the follicle acquires the ability to synthesize estradiol and progesterone and ..
  35. CYTOMATION MOFLO MLS FLOW CYTOMETER
    Michael Axthelm; Fiscal Year: 1999
    ..subpopulations in peripheral blood, lymph nodes, thymus, bone marrow, amniotic fluid, chorion and decidua, corpus luteum, and human, monkey and mouse brain...
  36. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 2005
    In the human, estrogens are synthesized in a number of tissue sites including ovarian granulosa cells and corpus luteum, placental syncytiotrophoblast, various sites in the brain, as well as adipose tissue...
  37. FAS ANTIGEN AND OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2000
    ..Quantify changes in levels of expression of Fas antigen during induction of follicular and corpus luteum development and regression using RT-PCR and flow cytometry...
  38. OVARIAN ENDOCRINE REGULATION
    HAROLD BEHRMAN; Fiscal Year: 1999
    ..H202 production in the ovary, determine the mechanisms of protection against and detoxification of H202 in the corpus luteum, and to evaluate the role of heat shock proteins as possible mediators of stress responses in the corpus ..
  39. ACTION OF GONADOTROPINS AND EICOSANOIDS IN LUTEAL CELLS
    CH RAO; Fiscal Year: 1992
    ..potentially contribute novel concepts in the area of the molecular mechanism of gonadotropin and PGs action in corpus luteum. Such concepts do not necessarily conflict with the importance of cell surface binding in the action of ..
  40. METALLOPROTEINASES AND OVARIAN FUNCTION
    Thomas Curry; Fiscal Year: 1999
    ..extracellular matrix remodeling during follicular development, ovulation, and formation and regression of the corpus luteum (CL)...
  41. BIOCHEMICAL STUDIES ON THE LH-HCG RECEPTOR
    Brij Saxena; Fiscal Year: 1990
    ..These studies are vital to understand the mechanism of hormone action at the molecular level during normal and abnormal gonadal function...
  42. FOLLICULAR REGULATION IN THE MAMMALIAN OVARY
    GILBERT GREENWALD; Fiscal Year: 1993
    ..The research is related to both fertility control and infertility. Work will proceed on a broad front. ..
  43. PROTEIN KINASE C OF THE CORPUS LUTEUM
    Kathleen Eyster; Fiscal Year: 1993
    The objective of this research is to better understand the hormonal control of primate corpus luteum function. The studies proposed herein are designed to investigate the role of protein kinase C...
  44. DEVELOPMENTAL POTENTIAL OF MARMOSET ES CELLS
    James Thomson; Fiscal Year: 2000
    ..including a short generation time, the routine birth of twins and triplets, and a prostaglandin sensitive corpus luteum that allows synchronization of reproductive cycles and efficient embryo transfer. In the proposal, we will: 1...
  45. Ovarian failure in LH/hCG receptor knockout animals
    CH RAO; Fiscal Year: 2005
    ..All techniques to be used in the proposed studies have already been established to obtain preliminary data presented in the proposal. ..
  46. THE STRUCTURAL BASIS OF RELAXIN ACTION
    Christian Schwabe; Fiscal Year: 1990
    ..Relaxin is produced in the corpus luteum of pregnancy or in the placenta and is a disulfide homolog of insulin that exhibits neither biological insulin ..
  47. Post-transcriptional gene regulation in the ovary
    Lane Christenson; Fiscal Year: 2007
    ..thereby coordinating multiple cellular and extracellular events with the formation of a "mature" oocyte and corpus luteum. Many downstream events (i.e...
  48. ROLE OF METALLOPROTEINASES IN OVARIAN FUNCTION
    Thomas Curry; Fiscal Year: 1993
    ..and gelatinase activity during follicular development and ovulation as well as during the life span of the corpus luteum. The goal of this proposal is to investigate the changes and regulation of the ovarian metalloproteinases ..
  49. COORDINATION OF FOLLICULOGENESIS AND OOGENESIS
    David Albertini; Fiscal Year: 2007
    ..abstract_text> ..
  50. COCAINE: EFFECTS ON OVARIAN FUNCTION
    SUSAN ATLAS; Fiscal Year: 1990
    ..1 will assess if a single injection of cocaine will affect gonadotropin-induced ovulation, oocyte maturation, corpus luteum formation, fertilization and/or preimplantation embryonic development...
  51. HORMONAL ACTIVATION OF CORPUS LUTEUM ADENYLATE CYCLASE
    Patrick Roche; Fiscal Year: 1992
    ..These studies should provide a more comprehensive framework for understanding signal transduction in gonadotropin-responsive tissues...
  52. GONADOTROPIN ACTION IN FOLLICLES AND CORPORA LUTEA
    MARY HUNZICKER DUNN; Fiscal Year: 1990
    ..hormone (FSH) and steroid hormones like estrogen; their physiological significance in the ovarian follicle and corpus luteum. At the level of the adenylyl cyclase enzyme, we propose to evaluate the molecular mechanism by which both Mg2+..
  53. HORMONAL CONTROL OF DELAYED IMPLANTATION
    RODNEY MEAD; Fiscal Year: 1991
    ..The last set of experiments is designed to determine the specific effects of LIF on its target organs by measuring such things as changes in cAMP, protein, RNA and DNA synthesis in the uterus and or blastocysts...
  54. Genomic Fingerprint of PGF2alpha and LH actions on the *
    Rajagopala Sridaran; Fiscal Year: 2006
    The corpus luteum (CL) undergoes dynamic changes in structure and function during its finite life-span...
  55. MECHANISMS OF LUTEAL REGULATION BY GONADOTROPINS
    PATRICK MC ILROY; Fiscal Year: 1992
    ..listed above by 1) investigating the interaction of LH/hCG with two putative types of hormone receptors in the corpus luteum, 2) investigating the role of guanyl nucleotides in the binding of LH/hCG to its receptors and in the ..
  56. LUTEAL FUNCTION--ROLES OF GROWTH FACTORS AND ONCOGENES
    PAUL TSANG; Fiscal Year: 1990
    The broad, long-term objective of this study is to further our understanding of the endocrinology of the corpus luteum by investigating regulatory mechanisms at the genetic normal cellular growth processes in physiological systems...
  57. REMODELLING OF THE UTERINE MATRIX AT IMPLANTATION
    Virginia Rider; Fiscal Year: 1991
    ..As the corpus luteum becomes established, peripheral progesterone concentrations increase and cells in mitoses switch from the ..
  58. ORGAN PATTERNING OF B 16 MELANOMA SECONDARY METASTASIS
    CHRISTOPHER STACKPOLE; Fiscal Year: 1992
    ..g., progesterone and beta-estradiol from the ovarian corpus luteum; various corticosteroids from the adrenal cortex) will be investigated...
  59. PECAM-1 AND REGULATION OF ANGIOGENESIS
    Nader Sheibani; Fiscal Year: 2003
    ..process of new capillary formation rarely occurs in normal adults, but is necessary during embryogenesis, corpus luteum formation, and wound healing...
  60. CORPUS LUTEUM SCP2 EXPRESSION PHOSPHORYLATION & FUNCTION
    MARK MC LEAN; Fiscal Year: 2000
    In the corpus luteum, cholesterol transport to the mitochondrial P450 side chain cleavage enzyme (P450scc) is thought to be the rate limiting step in steroid production...
  61. MOLECULAR REGULATION OF LUTEAL FUNCTION
    Geula Gibori; Fiscal Year: 2001
    The production of progesterone by the corpus luteum is crucial to prepare the endometrium for implantation and for the maintenance of pregnancy...
  62. FUNCTIONING OF CORPORA LUTEA
    HOWARD BRINKLEY; Fiscal Year: 1980
    ..Specific antisera to the gonadotropins and gonadal steroids will be employed to determine the cause and effect relationships of the hormones and their glands. ..
  63. REGULATION OF LUTEAL FUNCTION
    Geula Gibori; Fiscal Year: 2009
    The establishment and maintenance of pregnancy requires the coordinated hormonal regulation of corpus luteum (CL) function...
  64. REGULATION OF THE PRIMATE CORPUS LUTEUM
    FIRYAL KHAN DAWOOD; Fiscal Year: 1992
    The corpus luteum (CL) plays a major role in the primate reproductive process. The hormones produced by the CL are necessary for the successful implantation of the ovum in the uterus and hence a successful pregnancy...
  65. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 2001
    ..cells and luteal steroidogenic cells in the development and function of the primate (rhesus monkey) corpus luteum. The overall hypothesis is that luteal cell-microvascular endothelial cell interactions occur via vascular ..