gonads

Summary

Summary: The gamete-producing glands, OVARY or TESTIS.

Top Publications

  1. ncbi P450 aromatase expression in the temperature-sensitive sexual differentiation of salamander (Hynobius retardatus) gonads
    Natsuko Sakata
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Int J Dev Biol 49:417-25. 2005
  2. ncbi Sex determination and gonadal development in mammals
    Dagmar Wilhelm
    Division of Molecular Genetics and Development and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Physiol Rev 87:1-28. 2007
  3. ncbi Profiling gene expression during the differentiation and development of the murine embryonic gonad
    Christopher L Small
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 72:492-501. 2005
  4. ncbi A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    X Luo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Cell 77:481-90. 1994
  5. ncbi Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads
    George E Bentley
    Laboratory of Reproductive Neuroendocrinology, Department of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720 3140, USA
    Brain Res 1364:62-71. 2010
  6. ncbi Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
  7. ncbi Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells
    João Ramalho-Santos
    Center for Neuroscience and Cell Biology, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra 3004 517, Coimbra, Portugal
    Hum Reprod Update 15:553-72. 2009
  8. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
  9. ncbi Mammalian sex determination: from gonads to brain
    E Vilain
    Department of Human Genetics, UCLA School of Medicine and UCLA Children's Hospital, Los Angeles, California, 90095-1752, USA
    Mol Genet Metab 65:74-84. 1998
  10. ncbi Sex determination and the control of Sox9 expression in mammals
    Susanne Jakob
    Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
    FEBS J 278:1002-9. 2011

Research Grants

  1. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2003
  2. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
  3. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
  4. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
  5. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2005
  6. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2010
  7. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 2009
  8. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
  9. RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATES
    John Adams; Fiscal Year: 2001
  10. Defining the Mammalian Intercellular Bridge Interactome
    Martin Matzuk; Fiscal Year: 2009

Detail Information

Publications278 found, 100 shown here

  1. ncbi P450 aromatase expression in the temperature-sensitive sexual differentiation of salamander (Hynobius retardatus) gonads
    Natsuko Sakata
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Int J Dev Biol 49:417-25. 2005
    Sex differentiation of gonads in amphibians is believed to be controlled genetically, but altered epigenetically or environmentally...
  2. ncbi Sex determination and gonadal development in mammals
    Dagmar Wilhelm
    Division of Molecular Genetics and Development and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Physiol Rev 87:1-28. 2007
    ....
  3. ncbi Profiling gene expression during the differentiation and development of the murine embryonic gonad
    Christopher L Small
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 72:492-501. 2005
    ..With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development...
  4. ncbi A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    X Luo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Cell 77:481-90. 1994
    ..normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of ..
  5. ncbi Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads
    George E Bentley
    Laboratory of Reproductive Neuroendocrinology, Department of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720 3140, USA
    Brain Res 1364:62-71. 2010
    ..This overview summarizes the role of GnIH in modulation of mammalian reproductive physiology and suggests avenues for further study by those interested in the neuroendocrine control of reproductive physiology and sexual behavior...
  6. ncbi Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
    ..In the mouse, Fgf9 and Wnt4 are expressed in gonads of both sexes prior to sex determination...
  7. ncbi Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells
    João Ramalho-Santos
    Center for Neuroscience and Cell Biology, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra 3004 517, Coimbra, Portugal
    Hum Reprod Update 15:553-72. 2009
    ..The goal of this review was to identify and discuss common themes in mitochondrial function related to mammalian reproduction...
  8. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
    ..Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates...
  9. ncbi Mammalian sex determination: from gonads to brain
    E Vilain
    Department of Human Genetics, UCLA School of Medicine and UCLA Children's Hospital, Los Angeles, California, 90095-1752, USA
    Mol Genet Metab 65:74-84. 1998
    ..This factor causes the undifferentiated embryonic gonads to develop as testes rather than ovaries...
  10. ncbi Sex determination and the control of Sox9 expression in mammals
    Susanne Jakob
    Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
    FEBS J 278:1002-9. 2011
    ..The data reveal the importance of the positive regulatory loops to reinforce initial decisions, whereas the maintenance of the gonadal phenotype appears to rely on the active repression of the opposite pathway...
  11. ncbi Discovery and evaluation of candidate sex-determining genes and xenobiotics in the gonads of lake sturgeon (Acipenser fulvescens)
    Matthew C Hale
    Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN, 47906, USA
    Genetica 138:745-56. 2010
    ..Herein, we use pyrosequencing to study the evolution of genes expressed in the gonads of a polyploid fish, the lake sturgeon (Acipenser fulvescens)...
  12. ncbi SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, UK
    Dev Biol 274:271-9. 2004
    ....
  13. ncbi Nanog regulates proliferation during early fish development
    Esther Camp
    Department of Regenerative Medicine, Centro de Investigacion Principe Felipe, Valencia, Spain
    Stem Cells 27:2081-91. 2009
    ..expression of Ol-Nanog mRNA and protein during medaka (Oryzias latipes) embryonic development and in the adult gonads. Using medaka fish as a vertebrate model to study Nanog function, we demonstrate that Ol-Nanog is necessary for S-..
  14. ncbi Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene
    P de Santa Barbara
    Centre de Recherche de Biochime Macromoléculaire, CNRS UPR1142, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 18:6653-65. 1998
    ..Our work thus identifies SOX9 as an interaction partner of SF-1 that could be involved in the Sertoli cell-specific expression of AMH during embryogenesis...
  15. ncbi A honeybee storage protein gene, hex 70a, expressed in developing gonads and nutritionally regulated in adult fat body
    Juliana Ramos Martins
    Faculdade de Medicina de Ribeirao Preto, Departamento de Genetica, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Insect Physiol 54:867-77. 2008
    ..Both, transcript and protein subunits were also detected in developing gonads from workers, queens and drones, suggesting a role in ovary differentiation and testes maturation and functioning...
  16. ncbi Sexual development of the soma in the mouse
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Top Dev Biol 83:151-83. 2008
    ..However, recent evidence reveals expression differences between XX and XY brains prior to the time that hormones are circulating, suggesting that some influences on brain development may be autonomous to the cells of the brain...
  17. ncbi Histopathological biomarkers in estuarine fish species for the assessment of biological effects of contaminants
    G D Stentiford
    CEFAS Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Mar Environ Res 55:137-59. 2003
    ..As such, it provides a powerful integrative tool for the assessment of biological effects of contaminants in these environments...
  18. ncbi Transcriptional regulation of human CYP11A1 in gonads and adrenals
    Ing Cherng Guo
    Department of Veterinary Medicine, College of Bio Resources and Agriculture, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 14:509-15. 2007
    ..The TATA sequence could also contribute to tissue-specificity and hormonal regulation of CYP11A1 transcription. This article reviews recent studies focusing on adrenals and gonads.
  19. ncbi Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
    Y Sadovsky
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 92:10939-43. 1995
    The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal cortex and gonads and regulates the expression of several P450 steroid hydroxylases in vitro...
  20. ncbi New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation
    Gerrit J Bouma
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Biol Reprod 82:380-9. 2010
    ..GSD) genes are expressed in a unique population of somatic cells that differentiate into granulosa cells in XX gonads or Sertoli cells in XY gonads...
  21. ncbi Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation
    Sara Tomaselli
    Medical Genetics, Experimental Medicine Department, Sapienza University of Rome, Rome, Italy
    Hum Mutat 29:220-6. 2008
    ..The reported findings represent a further step toward a complete understanding of the complex mechanisms leading to DSDs...
  22. ncbi Differential gene expression in male and female rainbow trout embryos prior to the onset of gross morphological differentiation of the gonads
    Matthew C Hale
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    BMC Genomics 12:404. 2011
    ..Here we use data from a microarray and qRT-PCR to identify genes differentially expressed between the sexes at three time points in pre-hatch embryos, prior to the known timing of sexual differentiation in this species...
  23. ncbi Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver
    Parasakthy Kumaravelu
    Institute for Stem Cell Research, University of Edinburgh, West Main's Road, King's Buildings, UK
    Development 129:4891-9. 2002
    ..In accordance with this we observe growing numbers of definitive HSC/RUs in the circulation during days 11-13 of gestation, suggesting a route via which these HSCs migrate...
  24. ncbi Zebrafish monosex population reveals female dominance in sex determination and earliest events of gonad differentiation
    Sok Keng Tong
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
    Dev Biol 344:849-56. 2010
    ..This result indicates clear distinction of male and female gonads derived independently from primordial gonads...
  25. ncbi Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis)
    Elena Cubero-Leon
    Department of Biology and Environmental Science, University of Sussex, BN1 9QJ Falmer, Brighton, UK
    Aquat Toxicol 98:178-87. 2010
    ..These results show that the natural estrogen, E2, as well as the synthetic estrogen, EE2, induce alterations, dependent on reproductive stage, in the mRNA expression levels of 5-HT receptor and/or COX in the marine bivalve M. edulis...
  26. ncbi Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus
    Shigeho Ijiri
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Biol Reprod 78:333-41. 2008
    ..b>Gonads were isolated from all-female and all-male tilapia before (5-15 days after hatching [dah]) and after (25-70 dah) ..
  27. ncbi DNA methylation-mediated control of Sry gene expression in mouse gonadal development
    Koichiro Nishino
    Department of Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Yayoi 1 1 1, Bukyo ku, Tokyo 113 8657
    J Biol Chem 279:22306-13. 2004
    ..5 dpc, while the hypermethylated status was maintained in tissues that do not express the Sry gene. We concluded that expression of the Sry gene is under the control of an epigenetic mechanism mediated by DNA methylation...
  28. ncbi Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
    R Anderson
    Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Development 126:1655-64. 1999
    ..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established...
  29. ncbi The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1
    Dagmar Wilhelm
    Institut für Toxikologie und Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Genes Dev 16:1839-51. 2002
    ..Our data suggest a pathway in which the products of the Wt1 and Lhx9 genes activate expression of Sf1 and thus mediate early gonadogenesis...
  30. ncbi Components of the anti-Müllerian hormone signaling pathway in gonads
    N di Clemente
    Unité INSERM 493, 32 rue des Carnets, Clamart 92140, France
    Mol Cell Endocrinol 211:9-14. 2003
    ..family implicated in the regression of Müllerian ducts in male fetuses and in the development and function of gonads of both sexes...
  31. ncbi Expression of axolotl DAZL RNA, a marker of germ plasm: widespread maternal RNA and onset of expression in germ cells approaching the gonad
    A D Johnson
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Dev Biol 234:402-15. 2001
    ..These results suggest that, in axolotls, germ plasm components are insufficient to specify germ cells...
  32. ncbi Steroid signaling and temperature-dependent sex determination-Reviewing the evidence for early action of estrogen during ovarian determination in turtles
    Mary Ramsey
    Section of Integrative Biology, University of Texas, 2400 Speedway, Austin, TX 78712, United States
    Semin Cell Dev Biol 20:283-92. 2009
    ..Localized estrogen production facilitates ovarian development while inhibiting male-specific gene expression. At male-producing temperatures aromatase is not upregulated, thereby allowing testis development...
  33. ncbi The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni
    Thomas Quack
    Institute for Parasitology, Justus Liebig University, Giessen, Germany
    PLoS ONE 4:e6998. 2009
    ..The Src-like tyrosine-kinase SmTK3 of Schistosoma mansoni is expressed in the gonads, and its pharmacological inhibition reduces mitogenic activity and egg production in paired females in vitro...
  34. ncbi Ovotestes and XY sex reversal in a female with an interstitial 9q33.3-q34.1 deletion encompassing NR5A1 and LMX1B causing features of Genitopatellar syndrome
    Silke Schlaubitz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet A 143:1071-81. 2007
    ..This suggests that the locus 9q33-9q34 can be excluded for GPS and that the presented case is unique in its combination of GPS and NPS features caused by a microdeletion associated with loss of function of LMX1B and NR5A1...
  35. ncbi Identification and lineage tracing of two populations of somatic gonadal precursors in medaka embryos
    Shuhei Nakamura
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Dev Biol 295:678-88. 2006
    ....
  36. ncbi Early expression of AMH in chicken embryonic gonads precedes testicular SOX9 expression
    E Oreal
    Unité de recherches sur l Endocrinologie du Développement, INSERM U493, Ecole Normale Superieure, Montrouge, France
    Dev Dyn 212:522-32. 1998
    ..cloned the AMH promoter in search of SOX9 response elements, and we compared the expression of AMH and SOX9 in the gonads of chick embryos using in situ hybridization...
  37. ncbi Stage-specific gene expression during fish spermatogenesis as determined by laser-capture microdissection and quantitative-PCR in sea bass (Dicentrarchus labrax) gonads
    Jordi Viñas
    Institut de Ciencies del Mar, Consejo Superior de Investigaciones Cientificas, 08003 Barcelona, Spain
    Biol Reprod 79:738-47. 2008
    ....
  38. ncbi Temporal and spatial localization of three germline-specific proteins in medaka
    Yumiko Aoki
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki, Japan
    Dev Dyn 237:800-7. 2008
    ..During the sexual differentiation of the female gonads, the granules were found to be reduced in size in the germ cells undergoing cystic division and they showed a ..
  39. ncbi Characterization of intracytoplasmic prokaryote infections in Dreissena sp. (Bivalvia: Dreissenidae)
    D P Molloy
    New York State Museum, The State Education Department, Cultural Education Center, Albany 12230, USA
    Dis Aquat Organ 44:203-16. 2001
    ..6%), foot (12.5%), mantle (9.4%), labial palps (6.3%), digestive gland (6.3%), stomach (6.3%), and gonads (3.1%)...
  40. ncbi Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, 97403, USA
    Gene Expr Patterns 5:655-67. 2005
    ..We found that the onset of amh expression occurred while gonads were still undifferentiated and sox9a and cyp19a1a were already expressed...
  41. ncbi Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
    Robert A J Oostendorp
    Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands
    Blood 99:1183-9. 2002
    The aorta-gonads-mesonephros (AGM) region autonomously generates the first adult repopulating hematopoietic stem cells (HSCs) in the mouse embryo...
  42. ncbi Proliferating cell nuclear antigen in gonad and associated storage tissue of the Pacific oyster Crassostrea gigas: seasonal immunodetection and expression in laser microdissected tissues
    Alban Franco
    UMR 100 Ifremer, Physiologie et Ecophysiologie des Mollusques Marins, IFR 146 ICORE, Universite de Caen Basse Normandie, 14 032, Caen Cedex, France
    Cell Tissue Res 340:201-10. 2010
    ..As expected, immunolabeling was never observed from stage II spermatocytes to spermatozoa. In females, positively stained cells were detected from oogonia to growing oocytes with various labeled intracellular locations...
  43. ncbi Molecular analysis shows differential expression of R-spondin1 in zebrafish (Danio rerio) gonads
    Yanmei Zhang
    College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People s Republic of China
    Mol Biol Rep 38:275-82. 2011
    ..These preliminary findings suggest some aspects of RSPO1 like differential expression linked to sex determination may be conserved in fish while other aspects like subcellular localization differ from the mammalian RSPO1...
  44. ncbi Sex-related changes in estrogen receptors and aromatase gene expression and enzymatic activity during early development and sex differentiation in the European sea bass (Dicentrarchus labrax)
    Mercedes Blázquez
    Institut de Ciencies del Mar, Consejo Superior de Investigaciones Cientificas, Passeig Maritim, 37 49, 08003 Barcelona, Spain
    Gen Comp Endocrinol 158:95-101. 2008
    ..Results show clear sex-related differences in cyp19a gene expression and enzymatic activity in gonads, with females exhibiting significantly higher levels than males at 150 days post hatching (DPH), when histological ..
  45. ncbi Dax1 expression is dependent on steroidogenic factor 1 in the developing gonad
    Christine Hoyle
    Section of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, London SW3 6JB
    Mol Endocrinol 16:747-56. 2002
    ..Consistent with this, Dax1 is expressed at much reduced levels in gonads of embryos that are deficient in SF1...
  46. ncbi Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonads
    Stephanie C Bannister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Biol Reprod 85:22-30. 2011
    ..Using the embryonic chicken gonads as a model for vertebrate gonadogenesis, we previously reported that miRNAs are expressed in a sexually dimorphic ..
  47. ncbi Sex differences in brain developing in the presence or absence of gonads
    Tomaz Büdefeld
    Center for Animal Genomics, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia
    Dev Neurobiol 68:981-95. 2008
    ..SF-1 knockout (SF-1 KO) mice are born without gonads and adrenal glands and are not exposed to endogenous sex steroids during fetal/neonatal development...
  48. ncbi Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads
    Teruko Taketo
    Department of Biology, McGill University, Montreal, PQ, Canada
    Dev Dyn 233:612-22. 2005
    ..In the present study, we detected the endogenous SRY protein in normal XY fetal mouse gonads by Western blotting and immunohistochemistry...
  49. ncbi Effects of gestational diethylstilbestrol treatment on male and female gonads during early embryonic development
    Yayoi Ikeda
    Department of Histology and Cell Biology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Endocrinology 149:3970-9. 2008
    ..5 to E14.5, and gonads at E11.5, E12.5, and E14.5 were examined...
  50. ncbi Degree of sex reversal as related to plasma steroid levels in genetic female chickens (Gallus domesticus) treated with Fadrozole
    S Vaillant
    Institut Jacques Monod, UMR 7592, , Paris Cedex 05, France
    Mol Reprod Dev 65:420-8. 2003
    ..Eggs were injected with 1 mg Fadrozole on day 4 of incubation. In females having developed sex-reversed gonads, endocrine parameters (estradiol and testosterone) at and after 13 weeks of age were indicative of the degree of ..
  51. ncbi Genetic evidence against a role for W-linked histidine triad nucleotide binding protein (HINTW) in avian sex determination
    Craig A Smith
    Murdoch Childrens Research Institute and the Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
    Int J Dev Biol 53:59-67. 2009
    ..HINTW is conserved amongst all carinate (flying) birds and it is strongly expressed in the gonads and other tissues of female chicken embryos...
  52. ncbi Sox9b/sox9a2-EGFP transgenic medaka reveals the morphological reorganization of the gonads and a common precursor of both the female and male supporting cells
    Shuhei Nakamura
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki, Japan
    Mol Reprod Dev 75:472-6. 2008
    ..medaka line that mimics the expression of sox9b/sox9a2 to analyze the morphological reorganization of the gonads and characterize the sox9b-expressing cells during gonadal formation in this fish...
  53. ncbi Laser capture microdissection of gonads from juvenile zebrafish
    Anne Jørgensen
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Reprod Biol Endocrinol 7:97. 2009
    ..However, the small size of juvenile zebrafish and correspondingly their gonads complicates this type of investigation...
  54. ncbi Essential role of the posterior morphogen nanos for germline development in Drosophila
    S Kobayashi
    Institute of Biological Sciences, Gene Experiment Center and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    Nature 380:708-11. 1996
    ..is also essential for germline formation in Drosophila; pole cells lacking nanos activity fail to migrate into the gonads, and so do not become functional germ cells...
  55. ncbi Identification of novel genes associated with molecular sex differentiation in the embryonic gonads of rainbow trout (Oncorhynchus mykiss)
    T Cavileer
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844 3051, USA
    Sex Dev 3:214-24. 2009
    ..The transgenic fish permitted the collection of gonads from embryonic rainbow trout during the period of molecular sex differentiation in advance of any morphologically ..
  56. ncbi Alternative splicing and differential expression of P450c17 (CYP17) in gonads during sex transformation in the rice field eel
    Hongshi Yu
    Molecular and Developmental Genetics Laboratory, Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, 430072, PR China
    Biochem Biophys Res Commun 307:165-71. 2003
    ..Four isoforms of the CYP17 were generated in gonads by alternative splicing and polyadenylation...
  57. ncbi Cloning and characterization of a rice field eel vasa-like gene cDNA and its expression in gonads during natural sex transformation
    Ding Ye
    Laboratory of Molecular Genetics and Developmental Biology, College of Life Science, Wuhan University, Wuhan, Hubei 430072, P R China
    Biochem Genet 45:211-24. 2007
    ..RT-PCR analysis revealed that ma-vas was exclusively expressed in the gonads of the female, intersex, and male...
  58. ncbi Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads
    P Dolle
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Faculte de Medecine, Strasbourg, France
    EMBO J 8:1507-15. 1989
    ..In addition, Hox-5.2 is a marker for gonadal development. The possible involvement of such genes during inductive processes or organogenesis is discussed...
  59. ncbi Profiles of gonadal gene expression in the developing bovine embryo
    D G F Ross
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Sex Dev 3:273-83. 2009
    ..Therefore, Bos taurus may represent a useful model in which to study gene expression during sex determination, relevant to human development...
  60. ncbi A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans
    Yukihiko Kubota
    RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan
    Curr Biol 14:2011-8. 2004
    ....
  61. ncbi Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads
    Fengchao Wang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Prostaglandins Other Lipid Mediat 92:25-32. 2010
    ....
  62. ncbi Expression pattern of alphavbeta3 and alphavbeta5 integrin mRNA in mouse fetal gonads
    Maki Ishii
    Department of Veterinary Anatomy, The University of Tokyo, Japan
    J Reprod Dev 52:461-8. 2006
    ..We analyzed the expression patterns of the alphavbeta3 and alphavbeta5 integrins in mouse developing gonads (10.5-13.5 days post coitum) using whole-mount in situ hybridization...
  63. ncbi Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads
    Boris Thurisch
    Department of Neonatology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Mol Endocrinol 43:157-69. 2009
    ..Histology of the teratomas showed predominantly ectodermal and mesodermal structures. Our data demonstrate that Gata4 is critically involved in the function and integrity of the gonads in vivo.
  64. ncbi Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001
    Mark F Kirby
    Centre for Environment, Fisheries and Aquaculture Science Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, United Kingdom
    Environ Toxicol Chem 23:748-58. 2004
    ..The significance of the findings and possible mitigating influences are discussed in terms of the impacts on wild fish and the role of effluent treatment in reducing these...
  65. ncbi Nanos suppresses somatic cell fate in Drosophila germ line
    Yoshiki Hayashi
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Proc Natl Acad Sci U S A 101:10338-42. 2004
    ..We further found that some Nos-negative pole cells were able to migrate into the gonads, but they failed to develop as functional germ cells during postembryonic stages...
  66. ncbi cDNA cloning of chicken orexin receptor and tissue distribution: sexually dimorphic expression in chicken gonads
    T Ohkubo
    Faculty of Agriculture, Kagawa University, Miki, Kagawa 761 0795, Japan
    J Mol Endocrinol 31:499-508. 2003
    ..amount of cOXR mRNA was different between testis and ovary, while prepro-orexin mRNA is equally expressed in the gonads of both sexes in the chicken...
  67. ncbi Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs
    Irina Gyllenhammar
    Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvägen 18 A, 75236 Uppsala, Sweden
    Aquat Toxicol 91:102-9. 2009
    ..of the present study was to evaluate effects of larval exposure to clotrimazole on aromatase activity in brain and gonads, and on gonadal differentiation in Xenopus tropicalis frogs...
  68. ncbi Molecular mechanism of the photoperiodic response of gonads in birds and mammals
    Takashi Yoshimura
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, and Institute for Advanced Research, Nagoya University, Nagoya 464 8601, Japan
    Comp Biochem Physiol A Mol Integr Physiol 144:345-50. 2006
    ..However, the molecular mechanism underlying the photoperiodic response of gonads remains unknown for all living organisms...
  69. ncbi Possible involvement of organic anion transporting polypeptide 1c1 in the photoperiodic response of gonads in birds
    Nobuhiro Nakao
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, and Institute for Advanced Research, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Endocrinology 147:1067-73. 2006
    The photoperiodic response of the gonads requires T3, which is generated photoperiodically from T4 by type 2 iodothyronine deiodinase in the hypothalamus...
  70. ncbi Hypoxia alters gene expression in the gonads of zebrafish (Danio rerio)
    Dalma Martinovic
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA, 55804, USA
    Aquat Toxicol 95:258-72. 2009
    The objectives of this study were to characterize gene expression responses to hypoxia in gonads of mature zebrafish (Danio rerio), and to start characterizing modes of action by which hypoxia could potentially alter reproduction...
  71. ncbi Disorders of sexual differentiation in puppies and kittens: a diagnostic and clinical approach
    Stefano Romagnoli
    Department of Veterinary Clinical Sciences, University of Padua, Agripolis I 35020, Legnaro, Padua, Italy
    Vet Clin North Am Small Anim Pract 36:573-606, vii. 2006
    ....
  72. ncbi Cross talk between germ cells and gonadal somatic cells is critical for sex differentiation of the gonads in the teleost fish, medaka (Oryzias latipes)
    Minoru Tanaka
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444 8787, Japan
    Dev Growth Differ 50:273-8. 2008
    To evaluate the possible role of germ cells on sex differentiation of the gonads in vertebrates, the teleost fish, medaka (Oryzias latipes), was used to generate a gonad without germ cells...
  73. ncbi Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..Based on the timings in rats, we believe the programming window in humans is likely to be 8-14 weeks of gestation...
  74. ncbi Genetic control of germline sexual dimorphism in Drosophila
    Brian Oliver
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Int Rev Cytol 219:1-60. 2002
    ..remain somewhat controversial, it is clear that signals generated by somatic cells, probably in the embryonic gonads, are required as extrinsic factors for germline sex determination...
  75. ncbi Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol
    Anke Lange
    School of Biosciences, University of Exeter, Exeter EX4 4PS, United Kingdom
    Environ Sci Technol 43:1219-25. 2009
    ..In the wild, exposure to environmentally relevant concentrations of EE2 during early life has significantly wider implications for the sexual physiology in fish than has thus far been determined...
  76. ncbi Germ cell specification and migration in Drosophila and beyond
    Ana C Santos
    Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute and Department of Cell Biology at NYU School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Curr Biol 14:R578-89. 2004
    ..In particular, mechanisms that sense directional cues during germ cell migration seem to be shared between invertebrates and vertebrates...
  77. ncbi Genes expressed in Blue Fin Tuna (Thunnus thynnus) liver and gonads
    Valentina Chini
    Dipartimento di Biotecnologie e Scienze Molecolari, Universita dell Insubria, 3 Via Dunant, Varese, Italy
    Gene 410:207-13. 2008
    ..Accession numbers: EC 091633 to EC 093160; EG 629962 to EG 631176; EC 917676 to EC 919417; EG 999340 to EG 999999; EH 000001 to EH 000505; EH 667253 to EH 668984; EL 610526 to EL 611807; EC 42144 to EC 422414; and EH 379568 to EH 380065...
  78. ncbi HMG-CoA reductase guides migrating primordial germ cells
    M Van Doren
    Skirball Institute, Department of Cell Biology, New York University Medical Center, New York 10016, USA
    Nature 396:466-9. 1998
    ..We conclude that the regulated expression of HMG-CoA reductase has a critical developmental function in providing spatial information to guide migrating primordial germ cells...
  79. ncbi Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner
    Joaquin M Muriel
    Program in Cell Structure and Development, Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Development 132:4223-34. 2005
    ..We suggest that the distinct developmental roles and hemicentin-dependent assembly for fibulin-1 splice variants demonstrated here may be relevant to fibulin-1 and possibly other fibulin family members in non-nematode species...
  80. ncbi Aromatase, steroid-5-alpha-reductase type 1 and type 2 mRNA expression in gonads and in brain of Xenopus laevis during ontogeny
    R Urbatzka
    Department of Inland Fisheries, Leibniz Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, 12587 Berlin, Germany
    Gen Comp Endocrinol 153:280-8. 2007
    ..mRNA was analyzed in whole body homogenates from stage 12 to 48, while brain and gonads with kidney were studied separately from stage 48 to 66...
  81. ncbi Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes
    Annemiek Beverdam
    Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Hum Mol Genet 15:417-31. 2006
    ..whose expression is modulated during testis or ovary differentiation in mice, but these screens have used whole gonads, consisting of multiple cell types, or stages of gonadal development well beyond the time of sex determination...
  82. ncbi The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila
    Michelle A Li
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Cell Biol 5:994-1000. 2003
    ..In tj mutant gonads, somatic cells fail to inter-mingle and properly envelop germline cells, causing an early block in germ cell ..
  83. ncbi The active migration of Drosophila primordial germ cells
    M K Jaglarz
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA
    Development 121:3495-503. 1995
    ..In vivo this migration is oriented leading germ cells to the gonadal mesoderm. We suggest that this guidance involves stabilization of states of an intrinsic cellular oscillator resulting in cell polarization and oriented movement...
  84. ncbi zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila
    H T Broihier
    Skirball Institute, New York University Medical Center, NY, NY 10016, USA
    Development 125:655-66. 1998
    ..Finally, through analysis of a tinman zfh-1 double mutant, we show that zfh-1 acts in conjunction with tinman, another homeodomain protein, in the specification of lateral mesodermal derivatives, including the gonadal mesoderm...
  85. ncbi Radiation exposure to surgeon and patient in intramedullary nailing of the lower limb
    Sanjeev Madan
    Poole Hospital, Poole, UK
    Injury 33:723-7. 2002
    ..No study so far has measured the scatter radiation to the patient's gonads during intramedullary, particularly femoral, nailing...
  86. ncbi Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region
    T Hara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Immunity 11:567-78. 1999
    ..Moreover, multiple lineages of hematopoietic cells were generated in vivo when PCLP1 +CD45-cells were injected into neonatal liver of busulfan-treated mice. Thus, PCLP1 can be used to separate hemangioblasts that give rise to LTR-HSCs...
  87. ncbi ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans
    Krzysztof Drabikowski
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, PO Box 2543, CH 4002 Basel, Switzerland
    Dev Biol 282:27-38. 2005
    ..We propose that Ten-1 acts as a receptor for morphogenetic cue(s) and directly signals to the nucleus by translocation of its intracellular domain to the nucleus following its proteolytic release from the cell membrane...
  88. ncbi Fish full life-cycle testing for androgen methyltestosterone on medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan CERI, 19 14, Chuo machi, Kurume shi, Fukuoka, 830 0023, Japan
    Environ Toxicol Chem 23:774-81. 2004
    ..In the FFLC with medaka, MT induced masculinization of both secondary sex characteristics and gonads. We observed that all F0 fish in the 27...
  89. ncbi Effects of pulp and paper mill discharges on caged rainbow trout (Oncorhynchus mykiss): biomarker responses along a pollution gradient in the Biobio River, Chile
    Rodrigo Orrego
    Aquatic Systems Research Unit EULA Chile Environmental Sciences Centre, University of Concepcion, Chile
    Environ Toxicol Chem 25:2280-7. 2006
    ....
  90. ncbi Fish full life-cycle testing for 17beta-estradiol on medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan CERI, 3 2 7, Miyanojin, Kurume shi, Fukuoka 839 0801, Japan
    Environ Toxicol Chem 24:1259-66. 2005
    ..66 ng/L, suggesting that the ecological risk of E2 is higher than that of weak estrogens, such as nonylphenol and octylphenol...
  91. ncbi lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans
    Aaron M Bender
    Department of Molecular Biology, College of Agriculture, University of Wyoming, Dept 3944, Laramie, WY 82071, USA
    Dev Biol 273:335-49. 2004
    ..Analyses of the abnormal gonads indicate a defect in the lineages that generate cells of the sheath and spermatheca. xnp-1 encodes the C...
  92. ncbi An environmentally relevant concentration of estrogen induces arrest of male gonad development in zebrafish, Danio rerio
    Martina Fenske
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, 04318 Leipzig, Germany
    Environ Toxicol Chem 24:1088-98. 2005
    ..These findings suggest that continuous estrogen exposure had arrested the developmental transition of the gonads of genetic males from the early all-ovary stage to functional testes...
  93. ncbi Sexual dimorphic expression of DMRT1 and Sox9a during gonadal differentiation and hormone-induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus)
    Tohru Kobayashi
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki, Japan
    Dev Dyn 237:297-306. 2008
    ..These results suggest that tDMRT1 is a superior testicular differentiation marker in tilapia...
  94. ncbi Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity
    Tracy M Yamawaki
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158 2517, USA
    Genetics 178:513-26. 2008
    ..At these low levels of insulin/IGF-1 signaling, factors normally provided by the somatic gonad are no longer needed for germ-cell removal to increase the expression of DAF-16 target genes...
  95. ncbi Reproductive responses of common carp (Cyprinus carpio) exposed in cages to influent of the Las Vegas Wash in Lake Mead, Nevada, from late winter to early spring
    Erin M Snyder
    Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Sci Technol 38:6385-95. 2004
    ..Few differences among fish caged at different sites were potentially attributable to exposure to contaminants..
  96. ncbi The Chinese rare minnow (Gobiocypris rarus) as an in vivo model for endocrine disruption in freshwater teleosts: a full life-cycle test with diethylstilbestrol
    Xueping Zhong
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Aquat Toxicol 71:85-95. 2005
    ..These findings indicate that exposure to DES causes a variety of developmental, reproductive and transgenerational effects...
  97. ncbi Quantitative bio-imaging analysis for evaluation of sexual differentiation in germ cells of olvas-GFP/ST-II YI medaka (Oryzias latipes) nanoinjected in ovo with ethinylestradiol
    Takeshi Hano
    Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan
    Environ Toxicol Chem 24:70-7. 2005
    ..Observations of external secondary sex characteristics and histological examination of adult gonads showed complete sex reversal in some males after 0.5-, 2.5-, and 5...
  98. ncbi Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos
    Hidefumi Yoshioka
    Department of Natural Sciences, Hyogo University of Teacher Education, 942 1, Yashiro cho, Kato Gun, Hyogo 673 1494, Japan
    Dev Biol 280:150-61. 2005
    ..Our study demonstrated that FGF expressed in the developing mesonephros is involved in the development of the gonad at the sexually indifferent stages through stimulation of gonadal cell proliferation and gonadal marker gene expression...
  99. ncbi Reproductive, physiological, and biochemical responses in juvenile female rainbow trout (Oncorhynchus mykiss) exposed to sediment from pulp and paper mill industrial discharge areas
    Rodrigo Orrego
    Aquatic Systems Research Unit, EULA Chile Environmental Sciences Centre, University of Concepcion, P O Box 160 C, Concepcion, Chile
    Environ Toxicol Chem 24:1935-43. 2005
    ..Finally, the biomarker approach showed evidence that the sediment associated with pulp mill effluent discharges produces some effects in fish under laboratory conditions...
  100. ncbi Mercury concentrations in gonad, liver, and muscle of white sturgeon Acipenser transmontanus in the lower Columbia River
    M A H Webb
    Department of Fisheries and Wildlife, Oregon State University, 104 Nash Hall, Corvallis, Oregon 97331, USA
    Arch Environ Contam Toxicol 50:443-51. 2006
    ..In addition, immature male sturgeon with increased gonad mercury content had decreased GSIs. These results suggest that mercury, in the form of methylmercury, may have an effect on the reproductive potential of white sturgeon...
  101. ncbi In situ endocrine disrupting effects of cadmium on the reproduction of Ruditapes decussatus
    I Ketata
    Ecotoxicologie Marine, UR 09 03, Universite de Sfax, IPEIS, BP 805, 3018 Sfax, and Service nucléaire, Hopital Habib Bourguiba, Tunisia
    Comp Biochem Physiol C Toxicol Pharmacol 146:415-30. 2007
    ..Sex steroids (progesterone, testosterone, estradiol-17beta) were also measured by radio-immunoassay (RIA) in the gonads. The results showed that cadmium varied according to the reproductive cycle...

Research Grants73

  1. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2003
    ..so far have shown no osteoporotic phenotype, despite clear effects of estrogen (E2)-deficiency in the uterus and gonads. The inability to reconcile data from in vitro cell culture experiments and the mouse double ERalpha/beta knockout ..
  2. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  3. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
    ..Preliminary experiments show excess cell death in homozygous mutant juvenile gonads and suggest the hypothesis that 1) environmental and genetic factors affect oocyte survival in juveniles, and ..
  4. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
    ..at the promoter to exon one region completely inactivated the gene, which resulted in no detectable LHR in the gonads of homozygous animals...
  5. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2005
    ..members of the transforming growth factor beta superfamily, are tumor suppressors with specificity for the gonads and adrenal cortex...
  6. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2010
    ..These models have been indispensable for deciphering TGF2 superfamily signaling pathways in the gonads and modeling clinical reproductive diseases including infertility, premature ovarian failure, and ovarian and ..
  7. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 2009
    ..In humans, estrogens are produced in gonads, brain, placenta, bone, adipose stromal and vascular cells...
  8. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  9. RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATES
    John Adams; Fiscal Year: 2001
    ..World primates) are resistant to the cellular actions of steroid hormones produced by the adrenal gland and the gonads, and to the vitamin D prohormone 25-hydroxyvitamin D, and hormone 1,25-dihydroxyvitamin D...
  10. Defining the Mammalian Intercellular Bridge Interactome
    Martin Matzuk; Fiscal Year: 2009
    ..called intercellular bridges, are evolutionarily conserved structures that interconnect germ cells in the gonads of essentially all multicellular organisms...
  11. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    ..called intercellular bridges, are evolutionarily conserved structures that interconnect germ cells in the gonads of essentially all multicellular organisms...
  12. Deciphering T-box gene-dependent mesoderm development with synthetic probes
    James K Chen; Fiscal Year: 2010
    The transformation of vertebrate mesoderm into muscle, cartilage, bone, notochord, kidneys, gonads, blood, and other tissues is a classic example of morphogenesis and cellular differentiation during embryonic development...
  13. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 1999
    ..We have found that the 5'-untranslated region encoding the mRNAs in placenta, gonads and adipose tissue/fetal liver have distinct 5' termini that are encoded by different exons which are spliced onto ..
  14. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2010
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed...
  15. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1993
    ..We will analyze methylation using antibodies to 5-methylcytosine in histological preparations of gonads, and develop a method for PCR amplification from small numbers of germ cells, so as to examine specific HpaII ..