gonads

Summary

Summary: The gamete-producing glands, OVARY or TESTIS.

Top Publications

  1. pmc Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad
    Samantha A Jameson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Genet 8:e1002575. 2012
  2. pmc The human VASA gene is specifically expressed in the germ cell lineage
    D H Castrillon
    Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9585-90. 2000
  3. ncbi A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    X Luo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Cell 77:481-90. 1994
  4. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
  5. ncbi The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis
    Alexandra Penkner
    Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
    Dev Cell 12:873-85. 2007
  6. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
  7. ncbi SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, UK
    Dev Biol 274:271-9. 2004
  8. doi Regulation of Wolbachia ankyrin domain encoding genes in Drosophila gonads
    George Papafotiou
    Institute of Cellular and Developmental Biology, Biomedical Sciences Research Center Alexander Fleming, Vari 16672, Greece
    Res Microbiol 162:764-72. 2011
  9. ncbi Discovery and evaluation of candidate sex-determining genes and xenobiotics in the gonads of lake sturgeon (Acipenser fulvescens)
    Matthew C Hale
    Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN, 47906, USA
    Genetica 138:745-56. 2010
  10. doi Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads
    George E Bentley
    Laboratory of Reproductive Neuroendocrinology, Department of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720 3140, USA
    Brain Res 1364:62-71. 2010

Research Grants

  1. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2003
  2. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
  3. Gene networks regulating sex determination in vertebrates
    Thomas Kocher; Fiscal Year: 2009
  4. MOLECULAR BIOLOGY OF HORMONES THAT REGULATE REPRODUCTION
    Kelly Mayo; Fiscal Year: 1991
  5. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
  6. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1992
  7. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1991
  8. Do we need Y chromosome for successful reproduction?
    Monika A Ward; Fiscal Year: 2012
  9. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 1999
  10. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 2000

Detail Information

Publications306 found, 100 shown here

  1. pmc Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad
    Samantha A Jameson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Genet 8:e1002575. 2012
    ..at the level of the individual cell populations, we conducted microarrays on sorted cells from XX and XY mouse gonads at three time points spanning the period when the gonadal cells transition from sexually undifferentiated ..
  2. pmc The human VASA gene is specifically expressed in the germ cell lineage
    D H Castrillon
    Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9585-90. 2000
    ..The gene we have isolated is thus a highly specific marker of germ cells and should be useful for studies of human germ cell determination and function...
  3. ncbi A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    X Luo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Cell 77:481-90. 1994
    ..normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of ..
  4. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
    ..In the mouse, Fgf9 and Wnt4 are expressed in gonads of both sexes prior to sex determination...
  5. ncbi The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis
    Alexandra Penkner
    Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
    Dev Cell 12:873-85. 2007
    ..elegans meiosis. The reorganization of chromatin in early meiosis is disrupted in mtf-1/sun-1(jf18) gonads, concomitant with the absence of presynaptic homolog alignment...
  6. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
    ..Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates...
  7. ncbi SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, UK
    Dev Biol 274:271-9. 2004
    ....
  8. doi Regulation of Wolbachia ankyrin domain encoding genes in Drosophila gonads
    George Papafotiou
    Institute of Cellular and Developmental Biology, Biomedical Sciences Research Center Alexander Fleming, Vari 16672, Greece
    Res Microbiol 162:764-72. 2011
    ..immune system, uses the mitotic apparatus to ensure infection of daughter cells, migrates through the host to the gonads and causes reproductive phenotypes, most commonly cytoplasmic incompatibility (CI), i.e...
  9. ncbi Discovery and evaluation of candidate sex-determining genes and xenobiotics in the gonads of lake sturgeon (Acipenser fulvescens)
    Matthew C Hale
    Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN, 47906, USA
    Genetica 138:745-56. 2010
    ..Herein, we use pyrosequencing to study the evolution of genes expressed in the gonads of a polyploid fish, the lake sturgeon (Acipenser fulvescens)...
  10. doi Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads
    George E Bentley
    Laboratory of Reproductive Neuroendocrinology, Department of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720 3140, USA
    Brain Res 1364:62-71. 2010
    ..This overview summarizes the role of GnIH in modulation of mammalian reproductive physiology and suggests avenues for further study by those interested in the neuroendocrine control of reproductive physiology and sexual behavior...
  11. pmc Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene
    P de Santa Barbara
    Centre de Recherche de Biochime Macromoléculaire, CNRS UPR1142, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 18:6653-65. 1998
    ..Our work thus identifies SOX9 as an interaction partner of SF-1 that could be involved in the Sertoli cell-specific expression of AMH during embryogenesis...
  12. doi Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells
    João Ramalho-Santos
    Center for Neuroscience and Cell Biology, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra 3004 517, Coimbra, Portugal
    Hum Reprod Update 15:553-72. 2009
    ..The goal of this review was to identify and discuss common themes in mitochondrial function related to mammalian reproduction...
  13. pmc Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues
    Arthur P Arnold
    Department of Physiological Science and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA 90095 1606, USA
    J Neuroendocrinol 21:377-86. 2009
    ..These differences in their genomes cause sex differences in the functions of cells, both in the gonads and in non-gonadal tissues...
  14. pmc De Novo assembly of the Manila clam Ruditapes philippinarum transcriptome provides new insights into expression bias, mitochondrial doubly uniparental inheritance and sex determination
    Fabrizio Ghiselli
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Bologna, Italy
    Mol Biol Evol 29:771-86. 2012
    ..Ubiquitination can additionally regulate gene expression, playing a role in sex determination of several animals. These data enable us to develop a model that incorporates both the DUI literature and our new findings...
  15. ncbi Sex determination and gonadal development in mammals
    Dagmar Wilhelm
    Division of Molecular Genetics and Development and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Physiol Rev 87:1-28. 2007
    ....
  16. ncbi Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
    Robert A J Oostendorp
    Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands
    Blood 99:1183-9. 2002
    The aorta-gonads-mesonephros (AGM) region autonomously generates the first adult repopulating hematopoietic stem cells (HSCs) in the mouse embryo...
  17. doi Comparative expression analysis in mature gonads, liver and brain of turbot (Scophthalmus maximus) by cDNA-AFLPS
    Xoana Taboada
    Departamento de Genetica, Facultad de Biología CIBUS, Universidad de Santiago de Compostela Avda Lope Gómez de Marzoa, 15782 Santiago de Compostela, Spain
    Gene 492:250-61. 2012
    ..We found slight but important differences between sexes which deserve further investigation...
  18. pmc Differential gene expression in male and female rainbow trout embryos prior to the onset of gross morphological differentiation of the gonads
    Matthew C Hale
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    BMC Genomics 12:404. 2011
    ..Here we use data from a microarray and qRT-PCR to identify genes differentially expressed between the sexes at three time points in pre-hatch embryos, prior to the known timing of sexual differentiation in this species...
  19. ncbi Mammalian sex determination: from gonads to brain
    E Vilain
    Department of Human Genetics, UCLA School of Medicine and UCLA Children's Hospital, Los Angeles, California, 90095-1752, USA
    Mol Genet Metab 65:74-84. 1998
    ..This factor causes the undifferentiated embryonic gonads to develop as testes rather than ovaries...
  20. pmc Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells
    Charles Durand
    Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 104:20838-43. 2007
    ..We suggest that Bmp4 plays a relatively late role in the regulation of HSCs as they emerge in the midgestation AGM...
  21. ncbi Involvement of estrogens in the process of sex differentiation in two fish species: the rainbow trout (Oncorhynchus mykiss) and a tilapia (Oreochromis niloticus)
    Y Guiguen
    INRA Institut National de la recherche Agronomique, Rennes, Cedex, France
    Mol Reprod Dev 54:154-62. 1999
    ..Aromatase and estrogen receptor gene expression was studied in rainbow trout by semi-quantitative RT-PCR in gonads sampled before, during and after sex-differentiation...
  22. ncbi Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Stoneman 816, Boston, MA 02215, USA
    Lancet 366:74-85. 2005
    ..Further studies are warranted to establish the safety and effectiveness of leptin for the infertility and osteoporosis associated with hypothalamic amenorrhoea, and to clarify its role in anorexia nervosa...
  23. ncbi The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila
    Michelle A Li
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Cell Biol 5:994-1000. 2003
    ..In tj mutant gonads, somatic cells fail to inter-mingle and properly envelop germline cells, causing an early block in germ cell ..
  24. pmc Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
    Y Sadovsky
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 92:10939-43. 1995
    The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal cortex and gonads and regulates the expression of several P450 steroid hydroxylases in vitro...
  25. doi Zebrafish monosex population reveals female dominance in sex determination and earliest events of gonad differentiation
    Sok Keng Tong
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
    Dev Biol 344:849-56. 2010
    ..This result indicates clear distinction of male and female gonads derived independently from primordial gonads...
  26. ncbi DNA methylation-mediated control of Sry gene expression in mouse gonadal development
    Koichiro Nishino
    Department of Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Yayoi 1 1 1, Bukyo ku, Tokyo 113 8657
    J Biol Chem 279:22306-13. 2004
    ..5 dpc, while the hypermethylated status was maintained in tissues that do not express the Sry gene. We concluded that expression of the Sry gene is under the control of an epigenetic mechanism mediated by DNA methylation...
  27. doi Sex determination and the control of Sox9 expression in mammals
    Susanne Jakob
    Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
    FEBS J 278:1002-9. 2011
    ..The data reveal the importance of the positive regulatory loops to reinforce initial decisions, whereas the maintenance of the gonadal phenotype appears to rely on the active repression of the opposite pathway...
  28. ncbi Essential role of the posterior morphogen nanos for germline development in Drosophila
    S Kobayashi
    Institute of Biological Sciences, Gene Experiment Center and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    Nature 380:708-11. 1996
    ..is also essential for germline formation in Drosophila; pole cells lacking nanos activity fail to migrate into the gonads, and so do not become functional germ cells...
  29. doi Nanog regulates proliferation during early fish development
    Esther Camp
    Department of Regenerative Medicine, Centro de Investigacion Principe Felipe, Valencia, Spain
    Stem Cells 27:2081-91. 2009
    ..expression of Ol-Nanog mRNA and protein during medaka (Oryzias latipes) embryonic development and in the adult gonads. Using medaka fish as a vertebrate model to study Nanog function, we demonstrate that Ol-Nanog is necessary for S-..
  30. doi A critical time window of Sry action in gonadal sex determination in mice
    Ryuji Hiramatsu
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyoku, Tokyo 113 8657, Japan
    Development 136:129-38. 2009
    ..0-11.25 dpc, corresponding to a time window of only 6 hours after the normal onset of Sry expression in XY gonads. If Sry was activated after 11.3 dpc, Sox9 activation was not maintained, resulting in ovarian development...
  31. ncbi Defects in the germ line and gonads of mice lacking connexin43
    S C Juneja
    Department of Physiology, The University of Manitoba, Winnipeg, Manitoba, Canada R3E 3J7
    Biol Reprod 60:1263-70. 1999
    ..including connexin43 (Cx43), have been implicated in reproductive processes by virtue of their expression in adult gonads. In the present study, we examined the gonads of fetal and neonatal mice homozygous for a null mutation in the ..
  32. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..Based on the timings in rats, we believe the programming window in humans is likely to be 8-14 weeks of gestation...
  33. pmc GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells
    Kam Wing Ling
    Department of Cell Biology and Genetics, Eramus University Medical Center, 3000 DR Rotterdam, Netherlands
    J Exp Med 200:871-82. 2004
    ..Thus, GATA-2 plays at least two functionally distinct roles during ontogeny of HSCs: the production and expansion of HSCs in the aorta-gonad-mesonephros and the proliferation of HSCs in the adult bone marrow...
  34. pmc Profiling gene expression during the differentiation and development of the murine embryonic gonad
    Christopher L Small
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 72:492-501. 2005
    ..With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development...
  35. pmc Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling
    Maria I Mascarenhas
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Blood 114:4645-53. 2009
    ..5 of gestation in the aorta-gonads-mesonephros (AGM) region of the mouse embryo...
  36. doi Hematopoietic stem cell activity in the aorta-gonad-mesonephros region enhances after mid-day 11 of mouse development
    Erin Taylor
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, UK
    Int J Dev Biol 54:1055-60. 2010
    ..No clear correlation was established between IAC numbers and the presence of definitive HSCs...
  37. pmc Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod
    Kazue Nagasawa
    Faculty of Biosciences and Aquaculture, University of Nordland, Bodø, Norway
    PLoS ONE 7:e36908. 2012
    ..All mll and setd1 genes were highly expressed in gonads and fast muscle of adult cod, albeit at different levels, and they were differentially regulated with photoperiod ..
  38. pmc Sex differences in brain developing in the presence or absence of gonads
    Tomaz Büdefeld
    Center for Animal Genomics, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia
    Dev Neurobiol 68:981-95. 2008
    ..SF-1 knockout (SF-1 KO) mice are born without gonads and adrenal glands and are not exposed to endogenous sex steroids during fetal/neonatal development...
  39. ncbi Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo
    Z Cai
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunity 13:423-31. 2000
    ..Moreover, haploinsufficiency results in a dramatic change in the temporal and spatial distribution of HSCs, leading to their early appearance in the normal position in the aorta-gonad-mesonephros region and also in the yolk sac...
  40. pmc Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development
    Marian Peeters
    Erasmus Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    Development 136:2613-21. 2009
    ..Rather, it is due to instructive signaling from ventral tissues. Furthermore, we identify Hedgehog protein(s) as an HSC inducing signal...
  41. ncbi Female-specific increase in primordial germ cells marks sex differentiation in threespine stickleback (Gasterosteus aculeatus)
    Zachary R Lewis
    Department of Biology, Reed College, Portland, Oregon 97202, USA
    J Morphol 269:909-21. 2008
    ..markers of chromosomal sex combined with traditional histology to examine the transition of the bipotential gonads to ovaries or testes in threespine stickleback (Gasterosteus aculeatus)...
  42. ncbi Characterization of intracytoplasmic prokaryote infections in Dreissena sp. (Bivalvia: Dreissenidae)
    D P Molloy
    New York State Museum, The State Education Department, Cultural Education Center, Albany 12230, USA
    Dis Aquat Organ 44:203-16. 2001
    ..6%), foot (12.5%), mantle (9.4%), labial palps (6.3%), digestive gland (6.3%), stomach (6.3%), and gonads (3.1%)...
  43. ncbi Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta
    Marella F T R de Bruijn
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    Immunity 16:673-83. 2002
    ..Immunohistology of aorta-gonads-mesonephros (AGM) regions show that GFP(+) cells are specifically localized to the endothelial layer lining the ..
  44. pmc Notch and Egfr signaling act antagonistically to regulate germ-line stem cell niche formation in Drosophila male embryonic gonads
    Yu Kitadate
    Okazaki Institute for Integrative Bioscience, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Proc Natl Acad Sci U S A 107:14241-6. 2010
    ..However, it remains unclear how the proper niche size and location are regulated within the developing gonads. In the Drosophila testis, the hub cells that form the GSC niche are derived from a subset of somatic gonadal ..
  45. pmc A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway
    Jill J Weyers
    Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, USA
    Dev Biol 353:217-28. 2011
    ..Our findings shed light on the complexities of gonadogenesis and the genetic regulation required for proper organ formation...
  46. ncbi Nutritional status affects 20-hydroxyecdysone concentration and progression of oogenesis in Drosophila melanogaster
    J Terashima
    Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    J Endocrinol 187:69-79. 2005
    ..Starvation causes the ovary to retain the ecdysteroid it produces, thus enabling individual egg chambers to undergo apoptosis and thus control the number of eggs produced in relation to food intake...
  47. pmc Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation
    Katie J Torley
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Reprod Biol Endocrinol 9:2. 2011
    ..We postulate these expression patterns are regulated by small non-coding RNAs called microRNAs (miRNAs). The aim of this study was to identify the expression of miRNAs in mammalian fetal gonads using sheep as a model.
  48. ncbi An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells
    Catherine Robin
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Dev Cell 11:171-80. 2006
    ..Thus, our studies support an unexpected role for IL-3 during development and strongly suggest that IL-3 functions as a proliferation and/or survival factor for the earliest HSCs in the embryo...
  49. doi Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonads
    Stephanie C Bannister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Biol Reprod 85:22-30. 2011
    ..Using the embryonic chicken gonads as a model for vertebrate gonadogenesis, we previously reported that miRNAs are expressed in a sexually dimorphic ..
  50. pmc Four-dimensional analysis of vascularization during primary development of an organ, the gonad
    Douglas Coveney
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:7212-7. 2008
    ..We show that vascularization of XX and XY gonads is a highly dynamic, sexually dimorphic process. The XX gonad recruits vasculature by a typical angiogenic process...
  51. doi Comparable amounts of sex steroids are made outside the gonads in men and women: strong lesson for hormone therapy of prostate and breast cancer
    Fernand Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center CRCHUL 2705, Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    J Steroid Biochem Mol Biol 113:52-6. 2009
    ..Not adding an antiandrogen to castration in men treated for prostate cancer is equivalent to not prescribing a blocker of estrogens in women suffering from breast cancer because they are postmenopausal and have low circulating estradiol...
  52. ncbi Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver
    Parasakthy Kumaravelu
    Institute for Stem Cell Research, University of Edinburgh, West Main s Road, King s Buildings, UK
    Development 129:4891-9. 2002
    ..In accordance with this we observe growing numbers of definitive HSC/RUs in the circulation during days 11-13 of gestation, suggesting a route via which these HSCs migrate...
  53. ncbi Transcriptional regulation of human CYP11A1 in gonads and adrenals
    Ing Cherng Guo
    Department of Veterinary Medicine, College of Bio Resources and Agriculture, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 14:509-15. 2007
    ..The TATA sequence could also contribute to tissue-specificity and hormonal regulation of CYP11A1 transcription. This article reviews recent studies focusing on adrenals and gonads.
  54. pmc New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation
    Gerrit J Bouma
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Biol Reprod 82:380-9. 2010
    ..GSD) genes are expressed in a unique population of somatic cells that differentiate into granulosa cells in XX gonads or Sertoli cells in XY gonads...
  55. doi A honeybee storage protein gene, hex 70a, expressed in developing gonads and nutritionally regulated in adult fat body
    Juliana Ramos Martins
    Faculdade de Medicina de Ribeirao Preto, Departamento de Genetica, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Insect Physiol 54:867-77. 2008
    ..Both, transcript and protein subunits were also detected in developing gonads from workers, queens and drones, suggesting a role in ovary differentiation and testes maturation and functioning...
  56. ncbi Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis)
    Elena Cubero-Leon
    Department of Biology and Environmental Science, University of Sussex, BN1 9QJ Falmer, Brighton, UK
    Aquat Toxicol 98:178-87. 2010
    ..These results show that the natural estrogen, E2, as well as the synthetic estrogen, EE2, induce alterations, dependent on reproductive stage, in the mRNA expression levels of 5-HT receptor and/or COX in the marine bivalve M. edulis...
  57. ncbi Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus
    Shigeho Ijiri
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Biol Reprod 78:333-41. 2008
    ..b>Gonads were isolated from all-female and all-male tilapia before (5-15 days after hatching [dah]) and after (25-70 dah) ..
  58. ncbi Specification, migration and assembly of the somatic cells of the Drosophila gonad
    M Boyle
    Rockefeller University, NYC, NY 10021 6399, USA
    Development 121:1815-25. 1995
    ..Mutations in iab-4 abolish expression of abd A within these cells, and as a result block the coalescence of the gonad...
  59. ncbi Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol
    Anke Lange
    School of Biosciences, University of Exeter, Exeter EX4 4PS, United Kingdom
    Environ Sci Technol 43:1219-25. 2009
    ..In the wild, exposure to environmentally relevant concentrations of EE2 during early life has significantly wider implications for the sexual physiology in fish than has thus far been determined...
  60. pmc The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni
    Thomas Quack
    Institute for Parasitology, Justus Liebig University, Giessen, Germany
    PLoS ONE 4:e6998. 2009
    ..The Src-like tyrosine-kinase SmTK3 of Schistosoma mansoni is expressed in the gonads, and its pharmacological inhibition reduces mitogenic activity and egg production in paired females in vitro...
  61. pmc Steroid signaling and temperature-dependent sex determination-Reviewing the evidence for early action of estrogen during ovarian determination in turtles
    Mary Ramsey
    Section of Integrative Biology, University of Texas, 2400 Speedway, Austin, TX 78712, United States
    Semin Cell Dev Biol 20:283-92. 2009
    ..Localized estrogen production facilitates ovarian development while inhibiting male-specific gene expression. At male-producing temperatures aromatase is not upregulated, thereby allowing testis development...
  62. ncbi Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer
    Niels A Hammer
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Reproduction 130:203-12. 2005
    ..The relative expression of IMP1, IMP2 and IMP3 varied among tumor types and only IMP1 was detected in all carcinoma in situ cells. Thus IMPs, and in particular IMP1, may be useful auxiliary markers of testicular neoplasia...
  63. ncbi Minireview: transcriptional regulation of gonadal development and differentiation
    Susan Y Park
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocrinology 146:1035-42. 2005
    ..Defining these molecular pathways provides the foundation for understanding this critical developmental event and provides new insight into the causes of gonadal dysgenesis...
  64. pmc The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1
    Dagmar Wilhelm
    Institut für Toxikologie und Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Genes Dev 16:1839-51. 2002
    ..Our data suggest a pathway in which the products of the Wt1 and Lhx9 genes activate expression of Sf1 and thus mediate early gonadogenesis...
  65. ncbi Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
    R Anderson
    Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Development 126:1655-64. 1999
    ..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established...
  66. ncbi Expression of axolotl DAZL RNA, a marker of germ plasm: widespread maternal RNA and onset of expression in germ cells approaching the gonad
    A D Johnson
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Dev Biol 234:402-15. 2001
    ..These results suggest that, in axolotls, germ plasm components are insufficient to specify germ cells...
  67. ncbi Components of the anti-Müllerian hormone signaling pathway in gonads
    N di Clemente
    Unité INSERM 493, 32 rue des Carnets, Clamart 92140, France
    Mol Cell Endocrinol 211:9-14. 2003
    ..family implicated in the regression of Müllerian ducts in male fetuses and in the development and function of gonads of both sexes...
  68. ncbi Histopathological biomarkers in estuarine fish species for the assessment of biological effects of contaminants
    G D Stentiford
    CEFAS Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Mar Environ Res 55:137-59. 2003
    ..As such, it provides a powerful integrative tool for the assessment of biological effects of contaminants in these environments...
  69. ncbi Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation
    Sara Tomaselli
    Medical Genetics, Experimental Medicine Department, Sapienza University of Rome, Rome, Italy
    Hum Mutat 29:220-6. 2008
    ..The reported findings represent a further step toward a complete understanding of the complex mechanisms leading to DSDs...
  70. doi Comparative aspects of gonadal sex differentiation in medaka: a conserved role of developing oocytes in sexual canalization
    D Saito
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Higashiyama, Okazaki, Japan
    Sex Dev 3:99-107. 2009
    ..In medaka, oogenesis begins in female gonads, whereas oogenesis is suppressed and germ cells remain in an undifferentiated state in male gonads...
  71. doi Sexual development of the soma in the mouse
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Top Dev Biol 83:151-83. 2008
    ..However, recent evidence reveals expression differences between XX and XY brains prior to the time that hormones are circulating, suggesting that some influences on brain development may be autonomous to the cells of the brain...
  72. ncbi Ovotestes and XY sex reversal in a female with an interstitial 9q33.3-q34.1 deletion encompassing NR5A1 and LMX1B causing features of Genitopatellar syndrome
    Silke Schlaubitz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet A 143:1071-81. 2007
    ..This suggests that the locus 9q33-9q34 can be excluded for GPS and that the presented case is unique in its combination of GPS and NPS features caused by a microdeletion associated with loss of function of LMX1B and NR5A1...
  73. ncbi Early expression of AMH in chicken embryonic gonads precedes testicular SOX9 expression
    E Oreal
    Unité de recherches sur l Endocrinologie du Développement, INSERM U493, Ecole Normale Superieure, Montrouge, France
    Dev Dyn 212:522-32. 1998
    ..cloned the AMH promoter in search of SOX9 response elements, and we compared the expression of AMH and SOX9 in the gonads of chick embryos using in situ hybridization...
  74. doi Stage-specific gene expression during fish spermatogenesis as determined by laser-capture microdissection and quantitative-PCR in sea bass (Dicentrarchus labrax) gonads
    Jordi Viñas
    Institut de Ciencies del Mar, Consejo Superior de Investigaciones Cientificas, 08003 Barcelona, Spain
    Biol Reprod 79:738-47. 2008
    ....
  75. ncbi Identification and lineage tracing of two populations of somatic gonadal precursors in medaka embryos
    Shuhei Nakamura
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Dev Biol 295:678-88. 2006
    ....
  76. ncbi Temporal and spatial localization of three germline-specific proteins in medaka
    Yumiko Aoki
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki, Japan
    Dev Dyn 237:800-7. 2008
    ..During the sexual differentiation of the female gonads, the granules were found to be reduced in size in the germ cells undergoing cystic division and they showed a ..
  77. ncbi Sex-related changes in estrogen receptors and aromatase gene expression and enzymatic activity during early development and sex differentiation in the European sea bass (Dicentrarchus labrax)
    Mercedes Blázquez
    Institut de Ciencies del Mar, Consejo Superior de Investigaciones Cientificas, Passeig Maritim, 37 49, 08003 Barcelona, Spain
    Gen Comp Endocrinol 158:95-101. 2008
    ..Results show clear sex-related differences in cyp19a gene expression and enzymatic activity in gonads, with females exhibiting significantly higher levels than males at 150 days post hatching (DPH), when histological ..
  78. ncbi Dax1 expression is dependent on steroidogenic factor 1 in the developing gonad
    Christine Hoyle
    Section of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, London SW3 6JB
    Mol Endocrinol 16:747-56. 2002
    ..Consistent with this, Dax1 is expressed at much reduced levels in gonads of embryos that are deficient in SF1...
  79. ncbi Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, 97403, USA
    Gene Expr Patterns 5:655-67. 2005
    ..We found that the onset of amh expression occurred while gonads were still undifferentiated and sox9a and cyp19a1a were already expressed...
  80. ncbi Proliferating cell nuclear antigen in gonad and associated storage tissue of the Pacific oyster Crassostrea gigas: seasonal immunodetection and expression in laser microdissected tissues
    Alban Franco
    UMR 100 Ifremer, Physiologie et Ecophysiologie des Mollusques Marins, IFR 146 ICORE, Universite de Caen Basse Normandie, 14 032, Caen Cedex, France
    Cell Tissue Res 340:201-10. 2010
    ..As expected, immunolabeling was never observed from stage II spermatocytes to spermatozoa. In females, positively stained cells were detected from oogonia to growing oocytes with various labeled intracellular locations...
  81. ncbi Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads
    Teruko Taketo
    Department of Biology, McGill University, Montreal, PQ, Canada
    Dev Dyn 233:612-22. 2005
    ..In the present study, we detected the endogenous SRY protein in normal XY fetal mouse gonads by Western blotting and immunohistochemistry...
  82. doi Molecular analysis shows differential expression of R-spondin1 in zebrafish (Danio rerio) gonads
    Yanmei Zhang
    College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People s Republic of China
    Mol Biol Rep 38:275-82. 2011
    ..These preliminary findings suggest some aspects of RSPO1 like differential expression linked to sex determination may be conserved in fish while other aspects like subcellular localization differ from the mammalian RSPO1...
  83. pmc Effects of gestational diethylstilbestrol treatment on male and female gonads during early embryonic development
    Yayoi Ikeda
    Department of Histology and Cell Biology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Endocrinology 149:3970-9. 2008
    ..5 to E14.5, and gonads at E11.5, E12.5, and E14.5 were examined...
  84. doi Genetic evidence against a role for W-linked histidine triad nucleotide binding protein (HINTW) in avian sex determination
    Craig A Smith
    Murdoch Childrens Research Institute and the Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
    Int J Dev Biol 53:59-67. 2009
    ..HINTW is conserved amongst all carinate (flying) birds and it is strongly expressed in the gonads and other tissues of female chicken embryos...
  85. ncbi Degree of sex reversal as related to plasma steroid levels in genetic female chickens (Gallus domesticus) treated with Fadrozole
    S Vaillant
    Institut Jacques Monod, UMR 7592, C N R S et Universités Paris 6 et 7, Paris Cedex 05, France
    Mol Reprod Dev 65:420-8. 2003
    ..Eggs were injected with 1 mg Fadrozole on day 4 of incubation. In females having developed sex-reversed gonads, endocrine parameters (estradiol and testosterone) at and after 13 weeks of age were indicative of the degree of ..
  86. ncbi Sox9b/sox9a2-EGFP transgenic medaka reveals the morphological reorganization of the gonads and a common precursor of both the female and male supporting cells
    Shuhei Nakamura
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki, Japan
    Mol Reprod Dev 75:472-6. 2008
    ..medaka line that mimics the expression of sox9b/sox9a2 to analyze the morphological reorganization of the gonads and characterize the sox9b-expressing cells during gonadal formation in this fish...
  87. ncbi Molecular mechanism of the photoperiodic response of gonads in birds and mammals
    Takashi Yoshimura
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, and Institute for Advanced Research, Nagoya University, Nagoya 464 8601, Japan
    Comp Biochem Physiol A Mol Integr Physiol 144:345-50. 2006
    ..However, the molecular mechanism underlying the photoperiodic response of gonads remains unknown for all living organisms...
  88. ncbi A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans
    Yukihiko Kubota
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Curr Biol 14:2011-8. 2004
    ....
  89. ncbi Disorders of sexual differentiation in puppies and kittens: a diagnostic and clinical approach
    Stefano Romagnoli
    Department of Veterinary Clinical Sciences, University of Padua, Agripolis I 35020, Legnaro, Padua, Italy
    Vet Clin North Am Small Anim Pract 36:573-606, vii. 2006
    ....
  90. ncbi cDNA cloning of chicken orexin receptor and tissue distribution: sexually dimorphic expression in chicken gonads
    T Ohkubo
    Faculty of Agriculture, Kagawa University, Miki, Kagawa 761 0795, Japan
    J Mol Endocrinol 31:499-508. 2003
    ..amount of cOXR mRNA was different between testis and ovary, while prepro-orexin mRNA is equally expressed in the gonads of both sexes in the chicken...
  91. doi Cross talk between germ cells and gonadal somatic cells is critical for sex differentiation of the gonads in the teleost fish, medaka (Oryzias latipes)
    Minoru Tanaka
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444 8787, Japan
    Dev Growth Differ 50:273-8. 2008
    To evaluate the possible role of germ cells on sex differentiation of the gonads in vertebrates, the teleost fish, medaka (Oryzias latipes), was used to generate a gonad without germ cells...
  92. pmc Nanos suppresses somatic cell fate in Drosophila germ line
    Yoshiki Hayashi
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Proc Natl Acad Sci U S A 101:10338-42. 2004
    ..We further found that some Nos-negative pole cells were able to migrate into the gonads, but they failed to develop as functional germ cells during postembryonic stages...
  93. ncbi Alternative splicing and differential expression of P450c17 (CYP17) in gonads during sex transformation in the rice field eel
    Hongshi Yu
    Molecular and Developmental Genetics Laboratory, Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, 430072, PR China
    Biochem Biophys Res Commun 307:165-71. 2003
    ..Four isoforms of the CYP17 were generated in gonads by alternative splicing and polyadenylation...
  94. ncbi Possible involvement of organic anion transporting polypeptide 1c1 in the photoperiodic response of gonads in birds
    Nobuhiro Nakao
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, and Institute for Advanced Research, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Endocrinology 147:1067-73. 2006
    The photoperiodic response of the gonads requires T3, which is generated photoperiodically from T4 by type 2 iodothyronine deiodinase in the hypothalamus...
  95. ncbi Expression pattern of alphavbeta3 and alphavbeta5 integrin mRNA in mouse fetal gonads
    Maki Ishii
    Department of Veterinary Anatomy, The University of Tokyo, Japan
    J Reprod Dev 52:461-8. 2006
    ..We analyzed the expression patterns of the alphavbeta3 and alphavbeta5 integrins in mouse developing gonads (10.5-13.5 days post coitum) using whole-mount in situ hybridization...
  96. ncbi Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001
    Mark F Kirby
    Centre for Environment, Fisheries and Aquaculture Science Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, United Kingdom
    Environ Toxicol Chem 23:748-58. 2004
    ..The significance of the findings and possible mitigating influences are discussed in terms of the impacts on wild fish and the role of effluent treatment in reducing these...
  97. doi Identification of novel genes associated with molecular sex differentiation in the embryonic gonads of rainbow trout (Oncorhynchus mykiss)
    T Cavileer
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844 3051, USA
    Sex Dev 3:214-24. 2009
    ..The transgenic fish permitted the collection of gonads from embryonic rainbow trout during the period of molecular sex differentiation in advance of any morphologically ..
  98. pmc Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads
    P Dolle
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Faculte de Medecine, Strasbourg, France
    EMBO J 8:1507-15. 1989
    ..In addition, Hox-5.2 is a marker for gonadal development. The possible involvement of such genes during inductive processes or organogenesis is discussed...
  99. doi Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs
    Irina Gyllenhammar
    Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvägen 18 A, 75236 Uppsala, Sweden
    Aquat Toxicol 91:102-9. 2009
    ..of the present study was to evaluate effects of larval exposure to clotrimazole on aromatase activity in brain and gonads, and on gonadal differentiation in Xenopus tropicalis frogs...
  100. ncbi Hypoxia alters gene expression in the gonads of zebrafish (Danio rerio)
    Dalma Martinovic
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA, 55804, USA
    Aquat Toxicol 95:258-72. 2009
    The objectives of this study were to characterize gene expression responses to hypoxia in gonads of mature zebrafish (Danio rerio), and to start characterizing modes of action by which hypoxia could potentially alter reproduction...
  101. ncbi Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads
    Fengchao Wang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Prostaglandins Other Lipid Mediat 92:25-32. 2010
    ....

Research Grants74

  1. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2003
    ..so far have shown no osteoporotic phenotype, despite clear effects of estrogen (E2)-deficiency in the uterus and gonads. The inability to reconcile data from in vitro cell culture experiments and the mouse double ERalpha/beta knockout ..
  2. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  3. Gene networks regulating sex determination in vertebrates
    Thomas Kocher; Fiscal Year: 2009
    ..use quantitative PCR and in situ hybridization to quantify the normal pattern of gene expression in the developing gonads of our model system, the Nile tilapia...
  4. MOLECULAR BIOLOGY OF HORMONES THAT REGULATE REPRODUCTION
    Kelly Mayo; Fiscal Year: 1991
    ..Because FSH and LH play a crucial role in modulating the gametogenic and steroidogenic functions of the gonads, these regulatory hormones are likely to be important for homeostasis in the reproductive system...
  5. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
    ..Preliminary experiments show excess cell death in homozygous mutant juvenile gonads and suggest the hypothesis that 1) environmental and genetic factors affect oocyte survival in juveniles, and ..
  6. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1992
    ..Because FSH plays a crucial role in modulating the gametogenic and steroidogenic functions of the gonads, these regulatory hormones are likely to be important for homeostasis in the reproductive system...
  7. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1991
    ..Because FSH plays a crucial role in modulating the gametogenic and steroidogenic functions of the gonads, these regulatory hormones are likely to be important for homeostasis in the reproductive system...
  8. Do we need Y chromosome for successful reproduction?
    Monika A Ward; Fiscal Year: 2012
    ..affects spermatogenesis and fertility, testing directly for the as yet unknown function of these genes in mature gonads. We will also establish if Eif2s3x, an X encoded homologue of Eif2s3y, can replace Eif2s3y function in ..
  9. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 1999
    The glycoprotein hormones regulate the functions of the thyroid and gonads. Knowledge of the initial events in their actions is important for understanding health-related problems such as hyperthyroidism, precocious puberty, and ..
  10. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 2000
    The glycoprotein hormones regulate the functions of the thyroid and gonads. Knowledge of the initial events in their actions is important for understanding health-related problems such as hyperthyroidism, precocious puberty, and ..
  11. CENTRAL REGULATION OF FERTILITY IN PRIMATES
    REID NORMAN; Fiscal Year: 1993
    ..inhibit the release of gonadotropin- releasing hormone (GnRH), a peptide required for pituitary activation of the gonads. The long-term goal of this investigation is to define the physiological and environmental control of reproductive ..
  12. CENTRAL REGULATION OF FERTILITY IN PRIMATES
    REID NORMAN; Fiscal Year: 1990
    ..inhibit the release of gonadotropin- releasing hormone (GnRH), a peptide required for pituitary activation of the gonads. The long-term goal of this investigation is to define the physiological and environmental control of reproductive ..
  13. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2001
    ..at the promoter to exon one region completely inactivated the gene, which resulted in no detectable LHR in the gonads of homozygous animals...
  14. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
    ..at the promoter to exon one region completely inactivated the gene, which resulted in no detectable LHR in the gonads of homozygous animals...
  15. PARASITIC CASTRATION IN SNAILS--ROLE OF BIOGENIC AMINES
    TIMOTHY YOSHINO; Fiscal Year: 1999
    ..Parasitic castration of snails by larval trematodes, which manifests itself as histopathological changes in the gonads and/or lowered oviposition, represents one of the most dramatic examples of how parasites are capable of modifying ..
  16. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2004
    ..members of the transforming growth factor beta superfamily, are tumor suppressors with specificity for the gonads and adrenal cortex...
  17. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2003
    ..members of the transforming growth factor beta superfamily, are tumor suppressors with specificity for the gonads and adrenal cortex...
  18. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2002
    ..members of the transforming growth factor beta superfamily, are tumor suppressors with specificity for the gonads and adrenal cortex...
  19. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2005
    ..members of the transforming growth factor beta superfamily, are tumor suppressors with specificity for the gonads and adrenal cortex...
  20. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2001
    ..members of the transforming growth factor beta superfamily, are tumor suppressors with specificity for the gonads and adrenal cortex...
  21. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2011
    ..These models have been indispensable for deciphering TGF2 superfamily signaling pathways in the gonads and modeling clinical reproductive diseases including infertility, premature ovarian failure, and ovarian and ..
  22. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2010
    ..These models have been indispensable for deciphering TGF2 superfamily signaling pathways in the gonads and modeling clinical reproductive diseases including infertility, premature ovarian failure, and ovarian and ..
  23. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  24. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2004
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  25. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2006
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  26. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2005
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  27. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 2005
    ..In humans, estrogens are produced in gonads, brain, placenta, bone, adipose stromal and vascular cells...
  28. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 2006
    ..In humans, estrogens are produced in gonads, brain, placenta, bone, adipose stromal and vascular cells...
  29. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2006
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  30. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 2007
    ..In humans, estrogens are produced in gonads, brain, placenta, bone, adipose stromal and vascular cells...
  31. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  32. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 2009
    ..In humans, estrogens are produced in gonads, brain, placenta, bone, adipose stromal and vascular cells...
  33. RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATES
    John Adams; Fiscal Year: 2000
    ..World primates) are resistant to the cellular actions of steroid hormones produced by the adrenal gland and the gonads, and to the vitamin D prohormone 25-hydroxyvitamin D, and hormone 1,25-dihydroxyvitamin D...
  34. RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATES
    John Adams; Fiscal Year: 2001
    ..World primates) are resistant to the cellular actions of steroid hormones produced by the adrenal gland and the gonads, and to the vitamin D prohormone 25-hydroxyvitamin D, and hormone 1,25-dihydroxyvitamin D...
  35. RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATES
    John Adams; Fiscal Year: 1999
    ..World primates) are resistant to the cellular actions of steroid hormones produced by the adrenal gland and the gonads, and to the vitamin D prohormone 25-hydroxyvitamin D, and hormone 1,25-dihydroxyvitamin D...
  36. PARACRINE CONTROL OF STEROIDOGENESIS BY MIS
    Patricia Donahoe; Fiscal Year: 2000
    ..II receptor and found that it is expressed in Mullerian ducts, in Sertoli and granulosa cells of fetal and adult gonads, as well as in adult Leydig cells, which produce testosterone in the male testis...
  37. PRO-OPIOMELANOCORTIN SYNTHESIS IN TESTES
    Nathaniel Mills; Fiscal Year: 1992
    ..First, these peptides may help maintain the structure and organization of the gonads for spermatozoa production...
  38. Inhibitor of Adrenal Steroid Synthesis for Cancer Treatment
    SCOTT MCNEAR THACHER; Fiscal Year: 2010
    ..orphan receptor that regulates the major biosynthetic steps of steroid hormone synthesis in the adrenal cortex and gonads. Safe and effective inhibition of adrenal steroid synthesis has a number of potential applications in oncology, ..
  39. GONADAL AND PHENOTYPIC SEX DIFFERENTIATION
    FREDRICK GEORGE; Fiscal Year: 1991
    ..in this application are to elucidate the mechanisms that regulate differentiation and function of the fetal gonads and to understand the role that hormones secreted by the differentiated ovary or testis play in subsequent ..
  40. Defining the Mammalian Intercellular Bridge Interactome
    Martin Matzuk; Fiscal Year: 2009
    ..called intercellular bridges, are evolutionarily conserved structures that interconnect germ cells in the gonads of essentially all multicellular organisms...
  41. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    ..called intercellular bridges, are evolutionarily conserved structures that interconnect germ cells in the gonads of essentially all multicellular organisms...
  42. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2003
    ..so far have shown no osteoporotic phenotype, despite clear effects of estrogen (E2)-deficiency in the uterus and gonads. The inability to reconcile data from in vitro cell culture experiments and the mouse double ERalpha/beta knockout ..
  43. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2002
    ..so far have shown no osteoporotic phenotype, despite clear effects of estrogen (E2)-deficiency in the uterus and gonads. The inability to reconcile data from in vitro cell culture experiments and the mouse double ERalpha/beta knockout ..
  44. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2004
    ..so far have shown no osteoporotic phenotype, despite clear effects of estrogen (E2)-deficiency in the uterus and gonads. The inability to reconcile data from in vitro cell culture experiments and the mouse double ERalpha/beta knockout ..
  45. Deciphering T-box gene-dependent mesoderm development with synthetic probes
    James K Chen; Fiscal Year: 2010
    ..by applicant): The transformation of vertebrate mesoderm into muscle, cartilage, bone, notochord, kidneys, gonads, blood, and other tissues is a classic example of morphogenesis and cellular differentiation during embryonic ..
  46. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 1999
    ..We have found that the 5'-untranslated region encoding the mRNAs in placenta, gonads and adipose tissue/fetal liver have distinct 5' termini that are encoded by different exons which are spliced onto ..
  47. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2010
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed...
  48. HU-IME1 CHARACTERIZATION AND MALE INFERTILITY
    Wael Salameh; Fiscal Year: 1999
    ..Meiosis occurs only in the gonads. In the mammalian male, spermatogenesis is an ongoing process in which stem cell proliferation, meiosis, and ..
  49. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2011
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed...
  50. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Elias; Fiscal Year: 2009
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed...
  51. A NEW NEUROENDOCRINE MODEL OF SEASONAL BEHAVIORS
    MARY MENDONCA; Fiscal Year: 1999
    ..They 1) have a dissociated pattern of reproduction, mating when gonads are regressed and sex steroids are basal, and 2) are heterothermic, with arousal from hibernation being a potent ..
  52. METABOLIC BASIS OF CONJUGATED DIENES TOXICITY
    ADNAN ELFARRA; Fiscal Year: 1990
    ..Exposure of mice and rats to 1,3-butadiene results in lesions in gonads, lung and liver...
  53. A NEW NEUROENDOCRINE MODEL OF SEASONAL BEHAVIORS
    MARY MENDONCA; Fiscal Year: 2001
    ..They 1) have a dissociated pattern of reproduction, mating when gonads are regressed and sex steroids are basal, and 2) are heterothermic, with arousal from hibernation being a potent ..
  54. A NEW NEUROENDOCRINE MODEL OF SEASONAL BEHAVIORS
    MARY MENDONCA; Fiscal Year: 2000
    ..They 1) have a dissociated pattern of reproduction, mating when gonads are regressed and sex steroids are basal, and 2) are heterothermic, with arousal from hibernation being a potent ..
  55. Mitochondrial Functions of Dynamin-Related Proteins
    ALEXANDER VAN DER BLIEK; Fiscal Year: 2009
    ..elegans. We discovered that mitochondria in gonads of C...
  56. MECHANISMS OF ADRENAL CORTEX GROWTH/DIFFERENTIATION
    Gary Hammer; Fiscal Year: 2000
    ..steroidogenesis and the development and differentiation of steroidogenic organs, namely the adrenal glands and gonads, remain a fundamental question in mammalian biology...
  57. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1993
    ..We will analyze methylation using antibodies to 5-methylcytosine in histological preparations of gonads, and develop a method for PCR amplification from small numbers of germ cells, so as to examine specific HpaII ..
  58. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1991
    ..We will analyze methylation using antibodies to 5-methylcytosine in histological preparations of gonads, and develop a method for PCR amplification from small numbers of germ cells, so as to examine specific HpaII ..
  59. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1992
    ..We will analyze methylation using antibodies to 5-methylcytosine in histological preparations of gonads, and develop a method for PCR amplification from small numbers of germ cells, so as to examine specific HpaII ..
  60. PREOPTIC AREA BRAIN GRAFTS AND THE CONTROL OF OVULATION
    MARIE GIBSON; Fiscal Year: 1992
    The hypogonadal (hpg) mouse has infantile gonads due to a genetic inability to produce GnRH...
  61. GNRH DEFICIENCY -- CORRECTION BY PREOPTIC AREA GRAFTS
    MARIE GIBSON; Fiscal Year: 1991
    ..Thus the adult hpg mouse is infertile with infantile gonads. Implants of fetal normal mouse preoptic area (POA), containing GnRH cells, into the third ventricle of hpg mice ..
  62. GNRH DEFICIENCY -- CORRECTION BY PREOPTIC AREA GRAFTS
    MARIE GIBSON; Fiscal Year: 1993
    ..Thus the adult hpg mouse is infertile with infantile gonads. Implants of fetal normal mouse preoptic area (POA), containing GnRH cells, into the third ventricle of hpg mice ..
  63. Parenthood after Cancer
    Leslie Schover; Fiscal Year: 2003
    ..on sperm autogenesis, ovarian function, and the developing embryo; current efforts to use hemoprotection of the gonads during cancer treatment; prospective human studies of fertility in men and women undergoing cancer treatment; ..