gonads

Summary

Summary: The gamete-producing glands, OVARY or TESTIS.

Top Publications

  1. pmc The human VASA gene is specifically expressed in the germ cell lineage
    D H Castrillon
    Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9585-90. 2000
  2. ncbi The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis
    Alexandra Penkner
    Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
    Dev Cell 12:873-85. 2007
  3. ncbi Sex determination: insights from the chicken
    Craig A Smith
    Murdoch Childrens Research Institute and Department of Paediatrics, Royal Childrens Hospital, Parkville, Victoria, Australia
    Bioessays 26:120-32. 2004
  4. ncbi Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus
    Shigeho Ijiri
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Biol Reprod 78:333-41. 2008
  5. pmc Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad
    Samantha A Jameson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Genet 8:e1002575. 2012
  6. ncbi Comparative expression analysis in mature gonads, liver and brain of turbot (Scophthalmus maximus) by cDNA-AFLPS
    Xoana Taboada
    Departamento de Genetica, Facultad de Biología CIBUS, Universidad de Santiago de Compostela Avda Lope Gómez de Marzoa, 15782 Santiago de Compostela, Spain
    Gene 492:250-61. 2012
  7. ncbi DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos
    Craig A Smith
    Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Biol Reprod 68:560-70. 2003
  8. ncbi A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    X Luo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Cell 77:481-90. 1994
  9. ncbi Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
    Serge Nef
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Dev Biol 287:361-77. 2005
  10. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006

Detail Information

Publications339 found, 100 shown here

  1. pmc The human VASA gene is specifically expressed in the germ cell lineage
    D H Castrillon
    Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9585-90. 2000
    ..The gene we have isolated is thus a highly specific marker of germ cells and should be useful for studies of human germ cell determination and function...
  2. ncbi The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis
    Alexandra Penkner
    Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
    Dev Cell 12:873-85. 2007
    ..elegans meiosis. The reorganization of chromatin in early meiosis is disrupted in mtf-1/sun-1(jf18) gonads, concomitant with the absence of presynaptic homolog alignment...
  3. ncbi Sex determination: insights from the chicken
    Craig A Smith
    Murdoch Childrens Research Institute and Department of Paediatrics, Royal Childrens Hospital, Parkville, Victoria, Australia
    Bioessays 26:120-32. 2004
    ..The Z-linked gene, DMRT1, supports the Z-dosage model of avian sex determination. Two novel W-linked genes, ASW and FET1, represent candidate female determinants...
  4. ncbi Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus
    Shigeho Ijiri
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Biol Reprod 78:333-41. 2008
    ..b>Gonads were isolated from all-female and all-male tilapia before (5-15 days after hatching [dah]) and after (25-70 dah) ..
  5. pmc Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad
    Samantha A Jameson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Genet 8:e1002575. 2012
    ..at the level of the individual cell populations, we conducted microarrays on sorted cells from XX and XY mouse gonads at three time points spanning the period when the gonadal cells transition from sexually undifferentiated ..
  6. ncbi Comparative expression analysis in mature gonads, liver and brain of turbot (Scophthalmus maximus) by cDNA-AFLPS
    Xoana Taboada
    Departamento de Genetica, Facultad de Biología CIBUS, Universidad de Santiago de Compostela Avda Lope Gómez de Marzoa, 15782 Santiago de Compostela, Spain
    Gene 492:250-61. 2012
    ..We found slight but important differences between sexes which deserve further investigation...
  7. ncbi DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos
    Craig A Smith
    Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Biol Reprod 68:560-70. 2003
    ..DMRT1 is an avian Z-linked gene that shows higher expression in male gonads during embryogenesis and has been proposed as a putative testis-determining gene in birds...
  8. ncbi A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    X Luo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Cell 77:481-90. 1994
    ..normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of ..
  9. ncbi Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
    Serge Nef
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Dev Biol 287:361-77. 2005
    The primary event in mammalian sexual development is the differentiation of the bipotential gonads into either testes or ovaries. Our understanding of the molecular pathways specifying gonadal differentiation is still incomplete...
  10. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
    ..In the mouse, Fgf9 and Wnt4 are expressed in gonads of both sexes prior to sex determination...
  11. ncbi Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
    Robert A J Oostendorp
    Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands
    Blood 99:1183-9. 2002
    The aorta-gonads-mesonephros (AGM) region autonomously generates the first adult repopulating hematopoietic stem cells (HSCs) in the mouse embryo...
  12. pmc Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)
    Toshiaki Ara
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 100:5319-23. 2003
    ..PGCs migrate through the tissues of the embryos and colonize the gonads during development...
  13. ncbi Comparable amounts of sex steroids are made outside the gonads in men and women: strong lesson for hormone therapy of prostate and breast cancer
    Fernand Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center CRCHUL 2705, Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    J Steroid Biochem Mol Biol 113:52-6. 2009
    ..Not adding an antiandrogen to castration in men treated for prostate cancer is equivalent to not prescribing a blocker of estrogens in women suffering from breast cancer because they are postmenopausal and have low circulating estradiol...
  14. ncbi Sex-biased miRNA expression in Atlantic halibut (Hippoglossus hippoglossus) brain and gonads
    T T Bizuayehu
    Faculty of Biosciences and Aquaculture, University of Nordland, Bodø, Norway
    Sex Dev 6:257-66. 2012
    The role of miRNA in fish sexual development is not elucidated yet. We profiled miRNAs in gonads and brains of Atlantic halibut using SOLiD sequencing technology...
  15. ncbi Regulation of Wolbachia ankyrin domain encoding genes in Drosophila gonads
    George Papafotiou
    Institute of Cellular and Developmental Biology, Biomedical Sciences Research Center Alexander Fleming, Vari 16672, Greece
    Res Microbiol 162:764-72. 2011
    ..immune system, uses the mitotic apparatus to ensure infection of daughter cells, migrates through the host to the gonads and causes reproductive phenotypes, most commonly cytoplasmic incompatibility (CI), i.e...
  16. ncbi A critical time window of Sry action in gonadal sex determination in mice
    Ryuji Hiramatsu
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyoku, Tokyo 113 8657, Japan
    Development 136:129-38. 2009
    ..0-11.25 dpc, corresponding to a time window of only 6 hours after the normal onset of Sry expression in XY gonads. If Sry was activated after 11.3 dpc, Sox9 activation was not maintained, resulting in ovarian development...
  17. ncbi Time-lapse analysis of living mouse germ cell migration
    K A Molyneaux
    Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Dev Biol 240:488-98. 2001
    In mouse embryos, the primordial germ cells arise during gastrulation prior to, and distant from, the prospective gonads. Observations of PGCs in culture, and in fixed sections, have suggested, but not proved, that they migrate to the ..
  18. ncbi Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads
    George E Bentley
    Laboratory of Reproductive Neuroendocrinology, Department of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720 3140, USA
    Brain Res 1364:62-71. 2010
    ..This overview summarizes the role of GnIH in modulation of mammalian reproductive physiology and suggests avenues for further study by those interested in the neuroendocrine control of reproductive physiology and sexual behavior...
  19. pmc Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene
    P de Santa Barbara
    Centre de Recherche de Biochime Macromoléculaire, CNRS UPR1142, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 18:6653-65. 1998
    ..Our work thus identifies SOX9 as an interaction partner of SF-1 that could be involved in the Sertoli cell-specific expression of AMH during embryogenesis...
  20. ncbi Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells
    João Ramalho-Santos
    Center for Neuroscience and Cell Biology, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra 3004 517, Coimbra, Portugal
    Hum Reprod Update 15:553-72. 2009
    ..The goal of this review was to identify and discuss common themes in mitochondrial function related to mammalian reproduction...
  21. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
    ..Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates...
  22. pmc Chromatin dynamics during epigenetic reprogramming in the mouse germ line
    Petra Hajkova
    Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Nature 452:877-81. 2008
    ..5 (E11.5) after they enter into the developing gonads. Little is yet known about the mechanism involved, except that it is apparently an active process...
  23. pmc Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod
    Kazue Nagasawa
    Faculty of Biosciences and Aquaculture, University of Nordland, Bodø, Norway
    PLoS ONE 7:e36908. 2012
    ..All mll and setd1 genes were highly expressed in gonads and fast muscle of adult cod, albeit at different levels, and they were differentially regulated with photoperiod ..
  24. ncbi Molecular analysis shows differential expression of R-spondin1 in zebrafish (Danio rerio) gonads
    Yanmei Zhang
    College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People s Republic of China
    Mol Biol Rep 38:275-82. 2011
    ..These preliminary findings suggest some aspects of RSPO1 like differential expression linked to sex determination may be conserved in fish while other aspects like subcellular localization differ from the mammalian RSPO1...
  25. pmc The unique genomic properties of sex-biased genes: insights from avian microarray data
    Judith E Mank
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    BMC Genomics 9:148. 2008
    ..In order to develop a framework for the analysis of sex-biased genes, we present a characterization of microarray data comparing male and female gene expression in 18 day chicken embryos for brain, gonad, and heart tissue...
  26. ncbi Mouse germ cell development: from specification to sex determination
    Katherine A Ewen
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Cell Endocrinol 323:76-93. 2010
    ..PGCs migrate anteriorly and increase rapidly in number via mitotic division before colonizing the newly formed gonads. PGCs then express a different set of unique genes, their inherited epigenetic imprint is erased and an individual ..
  27. ncbi Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Stoneman 816, Boston, MA 02215, USA
    Lancet 366:74-85. 2005
    ..Further studies are warranted to establish the safety and effectiveness of leptin for the infertility and osteoporosis associated with hypothalamic amenorrhoea, and to clarify its role in anorexia nervosa...
  28. ncbi Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer
    Niels A Hammer
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Reproduction 130:203-12. 2005
    ..The relative expression of IMP1, IMP2 and IMP3 varied among tumor types and only IMP1 was detected in all carcinoma in situ cells. Thus IMPs, and in particular IMP1, may be useful auxiliary markers of testicular neoplasia...
  29. ncbi Germ cell specific expression of Vasa in rare minnow, Gobiocypris rarus
    Mengxi Cao
    Hubei Key Laboratory of Genetic Regulation and Integrated Biology, School of Life Sciences, Huazhong Normal University, Wuhan, Hubei 430079, China
    Comp Biochem Physiol A Mol Integr Physiol 162:163-70. 2012
    ..RT-PCR results showed that Grvas is expressed specifically in the gonads of male and female, it is maternally deposited into the eggs for embryos and is continuously expressed in the ..
  30. pmc Doubly uniparental inheritance of mitochondria as a model system for studying germ line formation
    Liliana Milani
    Department of Biologia Evoluzionistica Sperimentale, University of Bologna, Bologna, Italy
    PLoS ONE 6:e28194. 2011
    ..During male embryo development, spermatozoon mitochondria aggregate in proximity of the first cleavage furrow and end up in the primordial germ cells, while they are dispersed in female embryos...
  31. ncbi A crosstalk between bone and gonads
    Franck Oury
    Department of Genetics and Development, Columbia University, New York, New York, USA
    Ann N Y Acad Sci 1260:1-7. 2012
    ..This is particularly relevant to the interplay between bone and gonads because genetics and biochemical evidence have established that bone, via the osteoblast-derived hormone ..
  32. ncbi Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonads
    Stephanie C Bannister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Biol Reprod 85:22-30. 2011
    ..Using the embryonic chicken gonads as a model for vertebrate gonadogenesis, we previously reported that miRNAs are expressed in a sexually dimorphic ..
  33. pmc GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells
    Kam Wing Ling
    Department of Cell Biology and Genetics, Eramus University Medical Center, 3000 DR Rotterdam, Netherlands
    J Exp Med 200:871-82. 2004
    ..Thus, GATA-2 plays at least two functionally distinct roles during ontogeny of HSCs: the production and expansion of HSCs in the aorta-gonad-mesonephros and the proliferation of HSCs in the adult bone marrow...
  34. pmc Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
    Y Sadovsky
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 92:10939-43. 1995
    The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal cortex and gonads and regulates the expression of several P450 steroid hydroxylases in vitro...
  35. pmc Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation
    Katie J Torley
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Reprod Biol Endocrinol 9:2. 2011
    ..We postulate these expression patterns are regulated by small non-coding RNAs called microRNAs (miRNAs). The aim of this study was to identify the expression of miRNAs in mammalian fetal gonads using sheep as a model.
  36. ncbi Homozygous inactivation of Sox9 causes complete XY sex reversal in mice
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, D 79106 Freiburg, Germany
    Biol Reprod 74:195-201. 2006
    In the presence of the Y-chromosomal gene Sry, the bipotential mouse gonads develop as testes rather than as ovaries. The autosomal gene Sox9, a likely and possibly direct Sry target, can induce testis development in the absence of Sry...
  37. ncbi Analysis of the p450 aromatase gene expression in the Xenopus brain and gonad
    Junshin Iwabuchi
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajosui, Setagaya Ku, Tokyo 156 8550, Japan
    J Steroid Biochem Mol Biol 107:149-55. 2007
    Analysis of 5'-RACE clones revealed two Cyp19 transcript variants (gonad p450 aroms 1 and 2) in the gonads and one Cyp transcript (brain p450 arom) in the brain that differed in their 5'-untranslated region (UTR)...
  38. pmc Notch and Egfr signaling act antagonistically to regulate germ-line stem cell niche formation in Drosophila male embryonic gonads
    Yu Kitadate
    Okazaki Institute for Integrative Bioscience, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Proc Natl Acad Sci U S A 107:14241-6. 2010
    ..However, it remains unclear how the proper niche size and location are regulated within the developing gonads. In the Drosophila testis, the hub cells that form the GSC niche are derived from a subset of somatic gonadal ..
  39. ncbi Sex determination and gonadal development in mammals
    Dagmar Wilhelm
    Division of Molecular Genetics and Development and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Physiol Rev 87:1-28. 2007
    ....
  40. pmc De Novo assembly of the Manila clam Ruditapes philippinarum transcriptome provides new insights into expression bias, mitochondrial doubly uniparental inheritance and sex determination
    Fabrizio Ghiselli
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Bologna, Italy
    Mol Biol Evol 29:771-86. 2012
    ..Ubiquitination can additionally regulate gene expression, playing a role in sex determination of several animals. These data enable us to develop a model that incorporates both the DUI literature and our new findings...
  41. pmc Differential gene expression in male and female rainbow trout embryos prior to the onset of gross morphological differentiation of the gonads
    Matthew C Hale
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    BMC Genomics 12:404. 2011
    ..Here we use data from a microarray and qRT-PCR to identify genes differentially expressed between the sexes at three time points in pre-hatch embryos, prior to the known timing of sexual differentiation in this species...
  42. ncbi Mammalian sex determination: from gonads to brain
    E Vilain
    Department of Human Genetics, UCLA School of Medicine and UCLA Children's Hospital, Los Angeles, California, 90095-1752, USA
    Mol Genet Metab 65:74-84. 1998
    ..This factor causes the undifferentiated embryonic gonads to develop as testes rather than ovaries...
  43. pmc Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin
    Julien Y Bertrand
    Unité du Développement des Lymphocytes, Unité de Recherche Associée Centre National de la Recherche Scientifique 1961, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 102:134-9. 2005
    ..on the intraembryonic HSC site of origin, we purified multipotent hematopoietic progenitors from the aorta-gonads-mesonephros (AGM) of mice. This population, expressing c-Kit, AA4...
  44. ncbi Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, 97403, USA
    Gene Expr Patterns 5:655-67. 2005
    ..We found that the onset of amh expression occurred while gonads were still undifferentiated and sox9a and cyp19a1a were already expressed...
  45. ncbi In search of determinants: gene expression during gonadal sex differentiation
    K R Siegfried
    Max Planck Institute for Developmental Biology, Department of Genetics, Spemannstrasse 35, 72076 Tuebingen, Germany
    J Fish Biol 76:1879-902. 2010
    ..In the future, it will be essential to develop tools to assay the function of genes expressed during gonadal sex differentiation in fish...
  46. ncbi POP-1 controls axis formation during early gonadogenesis in C. elegans
    Kellee R Siegfried
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Development 129:443-53. 2002
    ..The pop-1(q645) allele is fully penetrant for the Sys gonadogenesis defect in hermaphrodites, but affects male gonads weakly; pop-1(q645) alters a conserved amino acid in the beta-catenin binding domain...
  47. ncbi Expression of gonadal soma derived factor (GSDF) is spatially and temporally correlated with early testicular differentiation in medaka
    Yasushi Shibata
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Gene Expr Patterns 10:283-9. 2010
    ..medaka at 6days post fertilization (dpf), coincident with the initiation of testicular differentiation in the XY gonads. Whole mount and section in situ hybridizations reaffirmed that Gsdf was expressed exclusively in primordial ..
  48. ncbi Sertoli cells of the mouse testis originate from the coelomic epithelium
    J Karl
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Dev Biol 203:323-33. 1998
    ..2-11.4 dpc, the coelomic epithelial cells of both sexes migrated into the gonad. In XY gonads, the migrating coelomic epithelial cells became Sertoli cells, as well as interstitial cells...
  49. pmc The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1
    Dagmar Wilhelm
    Institut für Toxikologie und Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Genes Dev 16:1839-51. 2002
    ..Our data suggest a pathway in which the products of the Wt1 and Lhx9 genes activate expression of Sf1 and thus mediate early gonadogenesis...
  50. ncbi DNA methylation-mediated control of Sry gene expression in mouse gonadal development
    Koichiro Nishino
    Department of Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Yayoi 1 1 1, Bukyo ku, Tokyo 113 8657
    J Biol Chem 279:22306-13. 2004
    ..5 dpc, while the hypermethylated status was maintained in tissues that do not express the Sry gene. We concluded that expression of the Sry gene is under the control of an epigenetic mechanism mediated by DNA methylation...
  51. ncbi Sex determination and the control of Sox9 expression in mammals
    Susanne Jakob
    Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
    FEBS J 278:1002-9. 2011
    ..The data reveal the importance of the positive regulatory loops to reinforce initial decisions, whereas the maintenance of the gonadal phenotype appears to rely on the active repression of the opposite pathway...
  52. pmc Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells
    Charles Durand
    Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 104:20838-43. 2007
    ..We suggest that Bmp4 plays a relatively late role in the regulation of HSCs as they emerge in the midgestation AGM...
  53. ncbi The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila
    Michelle A Li
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Cell Biol 5:994-1000. 2003
    ..In tj mutant gonads, somatic cells fail to inter-mingle and properly envelop germline cells, causing an early block in germ cell ..
  54. ncbi Essential role of the posterior morphogen nanos for germline development in Drosophila
    S Kobayashi
    Institute of Biological Sciences, Gene Experiment Center and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    Nature 380:708-11. 1996
    ..is also essential for germline formation in Drosophila; pole cells lacking nanos activity fail to migrate into the gonads, and so do not become functional germ cells...
  55. ncbi Involvement of estrogens in the process of sex differentiation in two fish species: the rainbow trout (Oncorhynchus mykiss) and a tilapia (Oreochromis niloticus)
    Y Guiguen
    INRA Institut National de la recherche Agronomique, Rennes, Cedex, France
    Mol Reprod Dev 54:154-62. 1999
    ..Aromatase and estrogen receptor gene expression was studied in rainbow trout by semi-quantitative RT-PCR in gonads sampled before, during and after sex-differentiation...
  56. ncbi Zebrafish monosex population reveals female dominance in sex determination and earliest events of gonad differentiation
    Sok Keng Tong
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
    Dev Biol 344:849-56. 2010
    ..This result indicates clear distinction of male and female gonads derived independently from primordial gonads...
  57. ncbi Nanog regulates proliferation during early fish development
    Esther Camp
    Department of Regenerative Medicine, Centro de Investigacion Principe Felipe, Valencia, Spain
    Stem Cells 27:2081-91. 2009
    ..expression of Ol-Nanog mRNA and protein during medaka (Oryzias latipes) embryonic development and in the adult gonads. Using medaka fish as a vertebrate model to study Nanog function, we demonstrate that Ol-Nanog is necessary for S-..
  58. ncbi Aromatase plays a key role during normal and temperature-induced sex differentiation of tilapia Oreochromis niloticus
    H D'Cotta
    CIRAD EMVT Centre de Coopération International en Recherche Agronomique pour le Développement, Station SCRIBE INRA, Campus de Beaulieu, Rennes, France
    Mol Reprod Dev 59:265-76. 2001
    ..b>Gonads were dissected between 486--702 degree x days...
  59. ncbi Discovery and evaluation of candidate sex-determining genes and xenobiotics in the gonads of lake sturgeon (Acipenser fulvescens)
    Matthew C Hale
    Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN, 47906, USA
    Genetica 138:745-56. 2010
    ..Herein, we use pyrosequencing to study the evolution of genes expressed in the gonads of a polyploid fish, the lake sturgeon (Acipenser fulvescens)...
  60. ncbi Characterization of early molecular sex differentiation in rainbow trout, Oncorhynchus mykiss
    Denise Vizziano
    INRA, SCRIBE, IFR 140, Rennes, France
    Dev Dyn 236:2198-206. 2007
    Early differentiation in rainbow trout gonads was investigated by expression profiling and in situ hybridization (ISH)...
  61. ncbi Nutritional status affects 20-hydroxyecdysone concentration and progression of oogenesis in Drosophila melanogaster
    J Terashima
    Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    J Endocrinol 187:69-79. 2005
    ..Starvation causes the ovary to retain the ecdysteroid it produces, thus enabling individual egg chambers to undergo apoptosis and thus control the number of eggs produced in relation to food intake...
  62. pmc Somatic cAMP signaling regulates MSP-dependent oocyte growth and meiotic maturation in C. elegans
    J Amaranath Govindan
    Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Development 136:2211-21. 2009
    ..Our findings highlight a remarkable similarity between the regulation of meiotic resumption by soma-germline interactions in C. elegans and mammals...
  63. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..Based on the timings in rats, we believe the programming window in humans is likely to be 8-14 weeks of gestation...
  64. pmc Profiling gene expression during the differentiation and development of the murine embryonic gonad
    Christopher L Small
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 72:492-501. 2005
    ..With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development...
  65. ncbi Defects in the germ line and gonads of mice lacking connexin43
    S C Juneja
    Department of Physiology, The University of Manitoba, Winnipeg, Manitoba, Canada R3E 3J7
    Biol Reprod 60:1263-70. 1999
    ..including connexin43 (Cx43), have been implicated in reproductive processes by virtue of their expression in adult gonads. In the present study, we examined the gonads of fetal and neonatal mice homozygous for a null mutation in the ..
  66. pmc The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni
    Thomas Quack
    Institute for Parasitology, Justus Liebig University, Giessen, Germany
    PLoS ONE 4:e6998. 2009
    ..The Src-like tyrosine-kinase SmTK3 of Schistosoma mansoni is expressed in the gonads, and its pharmacological inhibition reduces mitogenic activity and egg production in paired females in vitro...
  67. pmc Sexual dimorphism of gonadal structure and gene expression in germ cell-deficient loach, a teleost fish
    Takafumi Fujimoto
    Laboratory of Aquaculture Genetics and Genomics, Division of Marine Life Science, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041 8611, Japan
    Proc Natl Acad Sci U S A 107:17211-6. 2010
    ..Gene expression patterns in these male and female germ cell-deficient gonads were essentially the same as those in gonads of normal fish...
  68. ncbi The gsalpha gene: predominant maternal origin of transcription in human thyroid gland and gonads
    Giovanna Mantovani
    Institute of Endocrine Sciences University of Milan, Ospedale Maggiore IRCCS, Milan
    J Clin Endocrinol Metab 87:4736-40. 2002
    ....
  69. ncbi Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development
    Yukimasa Shibata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Dev Biol 361:349-57. 2012
    ..Our results show that the target selection by SWI/SNF-like complexes during C. elegans development is intricately regulated by accessory components...
  70. ncbi Expression profiles of SRY and SOX9 in rabbit gonads: the classical model of mammalian sex differentiation
    V Díaz-Hernández
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Cuautitlan, Mexico
    Sex Dev 2:152-66. 2008
    Sex determination in mammalian gonads depends on the concerted action of SRY and SOX at the genital ridge...
  71. ncbi SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, UK
    Dev Biol 274:271-9. 2004
    ....
  72. ncbi CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
    P W Reddien
    Howard Hughes Medical Institute, Department of Biology, 68 425, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Cell Biol 2:131-6. 2000
    ..We propose that CED-2/CrkII and CED-5/DOCK180 function to activate CED-10/Rac in a GTPase signalling pathway that controls the polarized extension of cell surfaces...
  73. ncbi Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development
    Y Toyooka
    Mitsubishi Kasei Institute of Life Sciences, 11 Minami Ooya, Machida, Tokyo, Japan
    Mech Dev 93:139-49. 2000
    ..that MVH protein was exclusively expressed in primordial germ cells just after their colonization of embryonic gonads and in germ cells undergoing gametogenic processes until the post-meiotic stage in both males and females...
  74. ncbi Germ cells are not the primary factor for sexual fate determination in goldfish
    Rie Goto
    Nanae Fresh Water Laboratory, Field Science Center for Northern Biosphere, Hokkaido University, 2 9 1 Sakura, Nanae, Kameda, Hokkaido 041 1105, Japan
    Dev Biol 370:98-109. 2012
    ..Next, we tested whether function could be restored to these empty gonads by transplantation of a single PGC into each embryo, and also determined the gonadal sex of the resulting germline ..
  75. ncbi Genetic network underlying temperature-dependent sex determination is endogenously regulated by temperature in isolated cultured Trachemys scripta gonads
    Christina M Shoemaker-Daly
    Molecular, Cell and Developmental Biology, University of Texas at Austin, Austin, Texas, USA
    Dev Dyn 239:1061-75. 2010
    ..molecular signal remains a mystery, and here we examine the molecular network underlying sex determination in gonads in vitro...
  76. ncbi Thyroid hormone regulation of mRNAs encoding thyrotropin beta-subunit, glycoprotein alpha-subunit, and thyroid hormone receptors alpha and beta in brain, pituitary gland, liver, and gonads of an adult teleost, Pimephales promelas
    Sean C Lema
    Physiology Program, Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA
    J Endocrinol 202:43-54. 2009
    ..Adult teleost models are increasingly used to evaluate the endocrine-disrupting effects of chemical contaminants, and our results provide a systemic assessment of TH-responsive genes during that life stage...
  77. ncbi Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol
    Anke Lange
    School of Biosciences, University of Exeter, Exeter EX4 4PS, United Kingdom
    Environ Sci Technol 43:1219-25. 2009
    ..In the wild, exposure to environmentally relevant concentrations of EE2 during early life has significantly wider implications for the sexual physiology in fish than has thus far been determined...
  78. ncbi Loss of Fgfr2 leads to partial XY sex reversal
    Stefan Bagheri-Fam
    Human Molecular Genetics Laboratory, Prince Henry s Institute of Medical Research, Monash Medical Centre, Melbourne 3168, Australia
    Dev Biol 314:71-83. 2008
    ..Since typical male-specific FGF9-binding to the coelomic epithelium was abolished in Fgfr2 mutant XY gonads, these results suggest that FGFR2 acts as the receptor for FGF9...
  79. pmc Characterization of the Caenorhabditis elegans Islet LIM-homeodomain ortholog, lim-7
    Roumen Voutev
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, United States
    FEBS Lett 583:456-64. 2009
    ..Finally, we identify a 45-bp regulatory element in the first intron that is necessary and sufficient for lim-7 gonadal sheath expression...
  80. pmc Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues
    Arthur P Arnold
    Department of Physiological Science and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA 90095 1606, USA
    J Neuroendocrinol 21:377-86. 2009
    ..These differences in their genomes cause sex differences in the functions of cells, both in the gonads and in non-gonadal tissues...
  81. ncbi Hematopoietic stem cell activity in the aorta-gonad-mesonephros region enhances after mid-day 11 of mouse development
    Erin Taylor
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, UK
    Int J Dev Biol 54:1055-60. 2010
    ..No clear correlation was established between IAC numbers and the presence of definitive HSCs...
  82. pmc A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway
    Jill J Weyers
    Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, USA
    Dev Biol 353:217-28. 2011
    ..Our findings shed light on the complexities of gonadogenesis and the genetic regulation required for proper organ formation...
  83. pmc Sex differences in brain developing in the presence or absence of gonads
    Tomaz Büdefeld
    Center for Animal Genomics, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia
    Dev Neurobiol 68:981-95. 2008
    ..SF-1 knockout (SF-1 KO) mice are born without gonads and adrenal glands and are not exposed to endogenous sex steroids during fetal/neonatal development...
  84. ncbi Female-specific increase in primordial germ cells marks sex differentiation in threespine stickleback (Gasterosteus aculeatus)
    Zachary R Lewis
    Department of Biology, Reed College, Portland, Oregon 97202, USA
    J Morphol 269:909-21. 2008
    ..markers of chromosomal sex combined with traditional histology to examine the transition of the bipotential gonads to ovaries or testes in threespine stickleback (Gasterosteus aculeatus)...
  85. pmc Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling
    Maria I Mascarenhas
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Blood 114:4645-53. 2009
    ..5 of gestation in the aorta-gonads-mesonephros (AGM) region of the mouse embryo...
  86. ncbi Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta
    Marella F T R de Bruijn
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    Immunity 16:673-83. 2002
    ..Immunohistology of aorta-gonads-mesonephros (AGM) regions show that GFP(+) cells are specifically localized to the endothelial layer lining the ..
  87. ncbi An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells
    Catherine Robin
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Dev Cell 11:171-80. 2006
    ..Thus, our studies support an unexpected role for IL-3 during development and strongly suggest that IL-3 functions as a proliferation and/or survival factor for the earliest HSCs in the embryo...
  88. ncbi Characterization of intracytoplasmic prokaryote infections in Dreissena sp. (Bivalvia: Dreissenidae)
    D P Molloy
    New York State Museum, The State Education Department, Cultural Education Center, Albany 12230, USA
    Dis Aquat Organ 44:203-16. 2001
    ..6%), foot (12.5%), mantle (9.4%), labial palps (6.3%), digestive gland (6.3%), stomach (6.3%), and gonads (3.1%)...
  89. ncbi Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo
    Z Cai
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunity 13:423-31. 2000
    ..Moreover, haploinsufficiency results in a dramatic change in the temporal and spatial distribution of HSCs, leading to their early appearance in the normal position in the aorta-gonad-mesonephros region and also in the yolk sac...
  90. pmc Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development
    Marian Peeters
    Erasmus Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    Development 136:2613-21. 2009
    ..Rather, it is due to instructive signaling from ventral tissues. Furthermore, we identify Hedgehog protein(s) as an HSC inducing signal...
  91. pmc Four-dimensional analysis of vascularization during primary development of an organ, the gonad
    Douglas Coveney
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:7212-7. 2008
    ..We show that vascularization of XX and XY gonads is a highly dynamic, sexually dimorphic process. The XX gonad recruits vasculature by a typical angiogenic process...
  92. ncbi A honeybee storage protein gene, hex 70a, expressed in developing gonads and nutritionally regulated in adult fat body
    Juliana Ramos Martins
    Faculdade de Medicina de Ribeirao Preto, Departamento de Genetica, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Insect Physiol 54:867-77. 2008
    ..Both, transcript and protein subunits were also detected in developing gonads from workers, queens and drones, suggesting a role in ovary differentiation and testes maturation and functioning...
  93. ncbi Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver
    Parasakthy Kumaravelu
    Institute for Stem Cell Research, University of Edinburgh, West Main s Road, King s Buildings, UK
    Development 129:4891-9. 2002
    ..In accordance with this we observe growing numbers of definitive HSC/RUs in the circulation during days 11-13 of gestation, suggesting a route via which these HSCs migrate...
  94. ncbi Transcriptional regulation of human CYP11A1 in gonads and adrenals
    Ing Cherng Guo
    Department of Veterinary Medicine, College of Bio Resources and Agriculture, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 14:509-15. 2007
    ..The TATA sequence could also contribute to tissue-specificity and hormonal regulation of CYP11A1 transcription. This article reviews recent studies focusing on adrenals and gonads.
  95. pmc New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation
    Gerrit J Bouma
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Biol Reprod 82:380-9. 2010
    ..GSD) genes are expressed in a unique population of somatic cells that differentiate into granulosa cells in XX gonads or Sertoli cells in XY gonads...
  96. ncbi Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis)
    Elena Cubero-Leon
    Department of Biology and Environmental Science, University of Sussex, BN1 9QJ Falmer, Brighton, UK
    Aquat Toxicol 98:178-87. 2010
    ..These results show that the natural estrogen, E2, as well as the synthetic estrogen, EE2, induce alterations, dependent on reproductive stage, in the mRNA expression levels of 5-HT receptor and/or COX in the marine bivalve M. edulis...
  97. ncbi Specification, migration and assembly of the somatic cells of the Drosophila gonad
    M Boyle
    Rockefeller University, NYC, NY 10021 6399, USA
    Development 121:1815-25. 1995
    ..Mutations in iab-4 abolish expression of abd A within these cells, and as a result block the coalescence of the gonad...
  98. ncbi Minireview: transcriptional regulation of gonadal development and differentiation
    Susan Y Park
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocrinology 146:1035-42. 2005
    ..Defining these molecular pathways provides the foundation for understanding this critical developmental event and provides new insight into the causes of gonadal dysgenesis...
  99. pmc Steroid signaling and temperature-dependent sex determination-Reviewing the evidence for early action of estrogen during ovarian determination in turtles
    Mary Ramsey
    Section of Integrative Biology, University of Texas, 2400 Speedway, Austin, TX 78712, United States
    Semin Cell Dev Biol 20:283-92. 2009
    ..Localized estrogen production facilitates ovarian development while inhibiting male-specific gene expression. At male-producing temperatures aromatase is not upregulated, thereby allowing testis development...
  100. ncbi Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
    R Anderson
    Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Development 126:1655-64. 1999
    ..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established...
  101. ncbi Expression of axolotl DAZL RNA, a marker of germ plasm: widespread maternal RNA and onset of expression in germ cells approaching the gonad
    A D Johnson
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Dev Biol 234:402-15. 2001
    ..These results suggest that, in axolotls, germ plasm components are insufficient to specify germ cells...

Research Grants63

  1. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
    ..Preliminary experiments show excess cell death in homozygous mutant juvenile gonads and suggest the hypothesis that 1) environmental and genetic factors affect oocyte survival in juveniles, and ..
  2. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed...
  3. The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland Develop
    BUFFY SUE ELLSWORTH; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Pituitary hormones are essential for survival after birth and for the normal development of gonads and thyroid gland...
  4. CELLS PROCESSING HIGH DENSITY LIPOPROTEINS
    Salman Azhar; Fiscal Year: 2013
    ..certain positive and negative modulators regulate the expression and function of SR-BI in the liver, adrenal and gonads. Specifically, we propose to determine the stimulatory and inhibitory actions of SF-1/LRH-1 and NHERF1/2 and SIK-1 ..
  5. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..towards our long-term goal of learning the independent and collaborative functions of all the Rhox genes in the gonads. PUBLIC HEALTH RELEVANCE: Mammalian reproduction requires successful ovulation...
  6. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2013
    ..These models have been indispensable for deciphering TGF2 superfamily signaling pathways in the gonads and modeling clinical reproductive diseases including infertility, premature ovarian failure, and ovarian and ..
  7. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    Carole R Mendelson; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: In humans, estrogens are synthesized in a variety of tissues, including the placenta, gonads, brain, bone and adipose...
  8. Mechanisms of Perchlorate-Induced Disruption of Sexual Differentiation
    FRANK ARTHUR VON HIPPEL; Fiscal Year: 2013
    ..gene functions that, under the insult of perchlorate contamination, disrupt normal development of male and female gonads. Experiments will also determine the hormonal mechanisms that translate genetic changes into developmental ..
  9. Neural basis of leptin action on reproduction
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed. Leptin also blunts the fasting-induced suppression of LH secretion...
  10. Functional study of novel transcriptional regulators of hematopoietic stem cells
    Shannon L McKinney-Freeman; Fiscal Year: 2012
    ..The RNA- binding protein, Zfp36l1, was predicted by our analyses to regulate HSC specification in the aorta-gonads- mesonephros (AGM)...
  11. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010
    ..the support of this grant, we have shown that the inhibins, a:p members of the TGFp superfamily, function in the gonads as tumor suppressors and that cyclin D2/inhibin a double mutants have slowed tumor development whereas p27/inhibin ..
  12. Mitochondrial Functions of Dynamin-Related Proteins
    Alexander M van der Bliek; Fiscal Year: 2012
    ..elegans. We discovered that mitochondria in gonads of C...
  13. Dmrt1 in gonadal sex maintenance
    Robin E Lindeman; Fiscal Year: 2013
    ..In fact, somatic cell sexual fates are actively maintained in the adult gonads. The Zarkower/Bardwell group recently discovered that Dmrt1 is essential for this maintenance program in the mouse ..
  14. Identification of XX DSD Mutations by RNA-seq and Comparative Genomics
    Vicki N Meyers-Wallen; Fiscal Year: 2013
    ..have not yet identified the long sought mechanism by which SOX9 transcription is normally extinguished in XX gonads. This could be a key step in the ovary pathway that opposes the testis pathway...
  15. Deciphering T-box gene-dependent mesoderm development with synthetic probes
    James K Chen; Fiscal Year: 2013
    ..by applicant): The transformation of vertebrate mesoderm into muscle, cartilage, bone, notochord, kidneys, gonads, blood, and other tissues is a classic example of morphogenesis and cellular differentiation during embryonic ..
  16. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    ..called intercellular bridges, are evolutionarily conserved structures that interconnect germ cells in the gonads of essentially all multicellular organisms...
  17. Do we need Y chromosome for successful reproduction?
    Monika A Ward; Fiscal Year: 2013
    ..affects spermatogenesis and fertility, testing directly for the as yet unknown function of these genes in mature gonads. We will also establish if Eif2s3x, an X encoded homologue of Eif2s3y, can replace Eif2s3y function in ..
  18. Derivation and Characterization of Germ Cells from Embryonic Stem Cells
    Amander Clark; Fiscal Year: 2013
    ..This will be achieved by expression profiling germ cells isolated from human fetal gonads by FACS...
  19. A genomic analysis of doublesex function in sex determination
    ERIN ALISA JIMENEZ; Fiscal Year: 2013
    ..the animal kingdom, such as cell autonomous splicing of specific sex factors in flies and hormonal secretion by gonads in humans, but converge upon a family of conserved genes, Dmrt's (dsx, mab-3 related transcription factors), ..
  20. NEW INSIGHTS INTO ROLE OF RET IN UROGENITAL DEVELOPMENT AND ANOMALIES
    Sanjay Jain; Fiscal Year: 2013
    ..RetY1015 (PLC3 pathway) results in hypoplastic, multicystic, multiplex kidneys with megaureter and failure of gonads to separate from the ureters;highly reminiscent of CAKUT...
  21. Role of T-box Genes in Mouse Development
    Virginia E Papaioannou; Fiscal Year: 2013
    ..Interesting expression patterns of T-box genes have been uncovered in the gonads and external genitalia and also in the pancreas during islet development...
  22. Hormonal regulation of the brain microenvironment and its contribution to brain m
    Diana M Cittelly; Fiscal Year: 2013
    ..Steroid hormones produced by gonads or adrenals cross the blood brain barrier, and are also produced locally by aromatase expressed in neurons and ..
  23. Genetic regulation of ovariole development in Drosophila
    Cassandra G Extavour; Fiscal Year: 2013
    ..provided by applicant): Reproductive success of all animals depends on the development and function of the gonads, which are responsible for producing and delivering eggs and sperm...
  24. Sensitized Screen in the Diversity Outcross Mouse Population
    STEVEN CARMEN MUNGER; Fiscal Year: 2013
    ..Aim 1 will characterize the expression of a subset of known sex determination genes in gonads from the DO panel, eight CC founder strains, and the sex-reversing Dax1/Nr0b1 mutant strain...
  25. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009
    ..severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  26. FEMALE REPRODUCTIVE TRACT DEVELOPMENT IN THE MOUSE
    Richard R Behringer; Fiscal Year: 2013
    ..In mammals, two pairs of genital ducts form within the mesonephroi associated with the fetal gonads regardless of sex genotype...
  27. Gene Expression, Duplicated Genes, and Sex Bias in Drosophila
    Richard P Meisel; Fiscal Year: 2010
    ..High quality gene expression data will be collected from three somatic tissues and the gonads of males and females of four species of Drosophila to test hypotheses regarding the evolution of gene expression...
  28. Role of Translational Regulators Nanos and Dazl in Preserving Totipotency
    Mary Lou King; Fiscal Year: 2013
    ..Xenopus PGCs deficient in dazl fail to migrate to the primordial gonads and are lost from the germline...
  29. In Utero Nicotine Exposure &Transgenerational Transmission of Asthma
    Virender K Rehan; Fiscal Year: 2013
    ..its transgenerational effect and whether this effect is determined by nicotine-induced epigenetic changes in the gonads. In Specific Aim 1A, we will determine the transgenerational development of asthma in G2 and G3 offspring of G1 ..
  30. MRI AND NEAR-INFRARED IMAGING OF THE TUMOR VASCULATURE VIA A NEW MARKER
    Aurelian Radu; Fiscal Year: 2012
    ..human tumor types analyzed, both early and advanced, and absent from all normal tissues except some areas of the gonads. Based on the information we have so far, this marker could be a better imaging target than any of the currently ..
  31. Neuroendocrinology, Sex Differences, and Reproduction
    Arthur P Arnold; Fiscal Year: 2013
    ..The target fields of research include study of how the brain and gonads communicate with each other to control reproduction, how hormones affect the ability of the brain to respond to ..
  32. Adaptive protein evolution of_Drosophila_germline stem cell genes_bam_and_bgcn_
    Daniel A Barbash; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Animals including humans contain a small number of cells in their gonads called germline stem cells (GSCs). These cells are essential for making sperm or eggs throughout the lifetime of the animal...
  33. Role of the Male-Specific Factor Sry in Brain Function
    ERIC J VILAIN; Fiscal Year: 2011
    ..Discovery of differential gene expression in the mammalian brain before the gonads start producing androgens led us to propose an alternative hypothesis...
  34. Transcriptional Control of Mammalian Sexual Development
    Sergei G Tevosian; Fiscal Year: 2013
    ..The expression of Dkk1 was dramatically increased (~10 fold) in embryonic gonads with GATA4-FOG2 interaction loss...
  35. Gene networks regulating sex determination in vertebrates
    Thomas D Kocher; Fiscal Year: 2011
    ..use quantitative PCR and in situ hybridization to quantify the normal pattern of gene expression in the developing gonads of our model system, the Nile tilapia...
  36. 2010 REPRODUCTIVE TRACT BIOLOGY GORDON RESEARCH CONFERENCE
    Richard R Behringer; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The mammalian reproductive tract includes the gonads (testes or ovaries), genital ducts and associated organs (oviduct, uterus, and vagina, epididymis, vas deferens, ..
  37. The Role of a Novel PIWI-Interacting Protein in Spermatogenesis
    JONATHAN PETER SAXE; Fiscal Year: 2011
    ..Specifically, we propose to 1) examine the expression patterns of Mapi during germline development and in mature gonads, 2) determine the function of Mapi during post-natal spermatogenesis, and 3) characterize Mapi protein and RNA ..
  38. Genetic analysis of adult germline stem cell maintenance and homing
    Adam Langenbacher; Fiscal Year: 2013
    ..upregulated in oocyte follicle cells and downregulated in testicular follicle cells during maturatin of the gonads. I hypothesize that Tgf[unreadable]-f and Tgf[unreadable] signaling may play a role in the maintenance, homing, ..
  39. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1993
    ..Because FSH plays a crucial role in modulating the gametogenic and steroidogenic functions of the gonads, these regulatory hormones are likely to be important for homeostasis in the reproductive system...
  40. The role of the cytoskeleton in germ cell apoptosis in C. elegans
    James R Priess; Fiscal Year: 2013
    ..The study focuses on adult gonads, where about 50% of germ cells normally undergo apoptosis...
  41. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
    ..at the promoter to exon one region completely inactivated the gene, which resulted in no detectable LHR in the gonads of homozygous animals...
  42. PARASITIC CASTRATION IN SNAILS--ROLE OF BIOGENIC AMINES
    TIMOTHY YOSHINO; Fiscal Year: 1999
    ..Parasitic castration of snails by larval trematodes, which manifests itself as histopathological changes in the gonads and/or lowered oviposition, represents one of the most dramatic examples of how parasites are capable of modifying ..
  43. Primordial germ cell differentiation and the initiation of testicular cancer
    Jason D Heaney; Fiscal Year: 2013
    ..In female embryonic gonads, RA induces expression of Stra8, which functions in differentiation events required for germ cell entry into ..
  44. PRO-OPIOMELANOCORTIN SYNTHESIS IN TESTES
    Nathaniel Mills; Fiscal Year: 1992
    ..First, these peptides may help maintain the structure and organization of the gonads for spermatozoa production...
  45. GONADAL AND PHENOTYPIC SEX DIFFERENTIATION
    FREDRICK GEORGE; Fiscal Year: 1993
    ..in this application are to elucidate the mechanisms that regulate differentiation and function of the fetal gonads and to understand the role that hormones secreted by the differentiated ovary or testis play in subsequent ..
  46. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2004
    ..so far have shown no osteoporotic phenotype, despite clear effects of estrogen (E2)-deficiency in the uterus and gonads. The inability to reconcile data from in vitro cell culture experiments and the mouse double ERalpha/beta knockout ..
  47. METABOLIC BASIS OF CONJUGATED DIENES TOXICITY
    ADNAN ELFARRA; Fiscal Year: 1992
    ..Exposure of mice and rats to 1,3-butadiene results in lesions in gonads, lung and liver...
  48. HU-IME1 CHARACTERIZATION AND MALE INFERTILITY
    Wael Salameh; Fiscal Year: 1999
    ..Meiosis occurs only in the gonads. In the mammalian male, spermatogenesis is an ongoing process in which stem cell proliferation, meiosis, and ..
  49. G Protein-Coupled Receptors with Leucine-Rich Repeats
    Aaron Hsueh; Fiscal Year: 2002
    ..proteins, the thyrotropin and gonadotropin receptors represent a subfamily with important functions in thyroid and gonads, respectively...
  50. A NEW NEUROENDOCRINE MODEL OF SEASONAL BEHAVIORS
    MARY MENDONCA; Fiscal Year: 2001
    ..They 1) have a dissociated pattern of reproduction, mating when gonads are regressed and sex steroids are basal, and 2) are heterothermic, with arousal from hibernation being a potent ..
  51. MECHANISMS OF ADRENAL CORTEX GROWTH/DIFFERENTIATION
    Gary Hammer; Fiscal Year: 2000
    ..steroidogenesis and the development and differentiation of steroidogenic organs, namely the adrenal glands and gonads, remain a fundamental question in mammalian biology...
  52. Physiology of LGR7 and LGR8 in Gonadal Tissues
    Aaron Hsueh; Fiscal Year: 2007
    ..is produced by testis Leydig cells as well as ovarian the cal and luteal cells, their physiological roles in the gonads are unclear...
  53. ORPHAN NUCLEAR RECEPTORS IN DEVELOPMENT AND DISEASE
    Gary Hammer; Fiscal Year: 2000
    ..steroidogenesis and the development and differentiation of steroidogenic organs, namely the adrenal glands and gonads, remain a fundamental question in mammalian biology...
  54. PITUITARY HORMONE REGULATION
    ZELTON SHARP; Fiscal Year: 1991
    ..and release of prolactin by the pituitary is under complex regulatory control of both the hypothalamus and the gonads. At the molecular level, cis-acting DNA regulatory elements responsible for control of the prolactin gene have ..
  55. Sex steroids and the thymus
    GILBERT KERSH; Fiscal Year: 2006
    A relationship exists between the gonads and the thymus. Castration results in a significant increase in the size of the thymus, and elevated serum levels of sex hormones results in a significant decrease in the size of the thymus...
  56. SMITH-LEMLI-OPITZ SYNDROME STEROIDOGENESIS
    Cedric Shackleton; Fiscal Year: 2002
    ..deficiency) it is likely that steroid hormone synthesis by the adrenal glands and gonads is impacted because all such compounds utilize cholesterol as precursor...
  57. Parenthood after Cancer
    Leslie Schover; Fiscal Year: 2004
    ..on sperm autogenesis, ovarian function, and the developing embryo; current efforts to use hemoprotection of the gonads during cancer treatment; prospective human studies of fertility in men and women undergoing cancer treatment; ..
  58. Androgen Receptor Expression in Developing Rat Forebrain
    Lydia Doncarlos; Fiscal Year: 2005
    ..sculpts the developing nervous system, insuring that the sexual phenotype of the brain matches that of the gonads. In rodents, testosterone exposure during the perinatal period permanently masculinizes not only the morphology, ..
  59. Role of Y Chromosome Genes in Spermatogenesis
    Jan Rohozinski; Fiscal Year: 2004
    ..of a single dominant gene on the Y chromosome, SRY, directs differentiation of the bipotential embryonic gonads into testes and subsequent development of male characteristics...
  60. BENZODIAZEPINE RECEPTOR AND ADRENAL DEVELOPMENT
    ERIC WIDMAIER; Fiscal Year: 2002
    ..PBR is expressed in all steroidogenic cells, including gonads, adrenals, placenta, and brain (glia), where it is believed to mediate transport of cholesterol to the inner ..
  61. STEROIDOGENESIS IN ADRENOCORTICAL & GONADAL TISSUE
    Robert Pedersen; Fiscal Year: 1991
    ..steroidogenesis activator polypeptide (SAP) previously identified by us in the rat adrenal cortex and gonads. This cycloheximide-sensitive 3215- kDal factor, recently isolated from a rat Leydig cell tumor and sequenced, is ..
  62. REGULATION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEIN
    Barbara Clark; Fiscal Year: 2005
    DESCRIPTION: (provided by applicant) Steroidogenesis in the adrenal and gonads is acutely controlled by tropic hormones via regulating the synthesis of the steroidogenic acute regulatory (StAR) protein...
  63. Genes regulated by activin receptor II signaling in gonadotropes
    T Kumar; Fiscal Year: 2009
    Activins are abundantly expressed in gonads and elicit important autocrine/paracrine actions within the pituitary and hypothalamus. Activins signal through two types of receptors, activin receptor II (ACVR2) and IIB (ACVR2B)...