clitoris

Summary

Top Publications

  1. ncbi [Adrenogenital syndrome: feminizing genital reconstruction]
    Indre Zaparackaite
    Kauno medicinos universiteto Vaiku chirurgijos klinika, Eiveniu 2, 3007 Kaunas
    Medicina (Kaunas) 38:706-11. 2002
  2. pmc Critical androgen-sensitive periods of rat penis and clitoris development
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, UK
    Int J Androl 33:e144-52. 2010
  3. ncbi A hair tourniquet resulting in strangulation and amputation of the clitoris
    Jennifer H Kuo
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance, California, USA
    Obstet Gynecol 99:939-41. 2002
  4. ncbi Solitary vascular malformation of the clitoris
    T Haritharan
    Department of Surgery, University Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur
    Med J Malaysia 61:258-9. 2006
  5. doi Pilonidal cyst involving the clitoris: a case report
    Teresa Baker
    Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Amarillo, TX 79106 1786, USA
    J Low Genit Tract Dis 12:127-9. 2008
  6. ncbi A female infant with Silver Russell Syndrome, mesocardia and enlargement of the clitoris
    Assimina Galli-Tsinopoulou
    4th Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Greece
    Hormones (Athens) 7:77-81. 2008
  7. pmc Clitoral sexual arousal: neuronal tracing study from the clitoris through the spinal tracts
    Nieves Martin-Alguacil
    Department of Neurobiology and Behavior, Rockefeller University, New York, New York, USA
    J Urol 180:1241-8. 2008
  8. ncbi Duplication and exstrophy of the bladder with clitoris and vagina duplex as well as uterus bicornis
    Wolfram Kluwe
    Department of Surgical Pediatrics, Children s Hospital, Inselspital, University of Bern, Bern, Switzerland
    Urology 70:591.e1-2. 2007
  9. ncbi Malignant rhabdoid tumor of the clitoris in an elderly patient: report of a case
    D Haidopoulos
    1st Department of Obstetrics and Gynecology, University of Athens, Alexandra Hospital, Greece
    Eur J Gynaecol Oncol 23:447-9. 2002
  10. doi Neuroanatomical evidence for a role of central melanocortin-4 receptors and oxytocin in the efferent control of the rodent clitoris and vagina
    Helene Gelez
    Pelvipharm Laboratories, Orsay Parc, Bâtiment Cèdres, Orsay, France
    J Sex Med 7:2056-67. 2010

Research Grants

  1. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
  2. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2001
  3. Testosterone dose response in surgically menopausal woment
    Shalender Bhasin; Fiscal Year: 2003
  4. Hypospadias: Interactions of Sex Steroids and Fgfr2
    Martin Cohn; Fiscal Year: 2005
  5. Hypospadias: Interactions of Sex Steroids and Fgfr2
    Martin Cohn; Fiscal Year: 2006
  6. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2003
  7. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2006
  8. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2002
  9. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2000
  10. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2004

Detail Information

Publications193 found, 100 shown here

  1. ncbi [Adrenogenital syndrome: feminizing genital reconstruction]
    Indre Zaparackaite
    Kauno medicinos universiteto Vaiku chirurgijos klinika, Eiveniu 2, 3007 Kaunas
    Medicina (Kaunas) 38:706-11. 2002
    ..There were 4 cases of vaginal stenosis and 2 cases of urethrovaginal fistula (all successfully repaired later). Early one staged genitoplasty and postoperative vaginal dilatations for the period of 6-12 months is recommended...
  2. pmc Critical androgen-sensitive periods of rat penis and clitoris development
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, UK
    Int J Androl 33:e144-52. 2010
    ..Foetal and/or postnatal TP exposure does not increase adult penile size above its 'predetermined' length though its growth towards this maximum is advanced by peripubertal TP treatment...
  3. ncbi A hair tourniquet resulting in strangulation and amputation of the clitoris
    Jennifer H Kuo
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance, California, USA
    Obstet Gynecol 99:939-41. 2002
    ..Appendages commonly involved include the toe, finger, and penis. We report a hair tourniquet resulting in amputation of the clitoris.
  4. ncbi Solitary vascular malformation of the clitoris
    T Haritharan
    Department of Surgery, University Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur
    Med J Malaysia 61:258-9. 2006
    Isolated involvement of the clitoris by vascular malformation (VM) is very rare. Clinically, the lesion simulates female pseudohermaphroditism...
  5. doi Pilonidal cyst involving the clitoris: a case report
    Teresa Baker
    Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Amarillo, TX 79106 1786, USA
    J Low Genit Tract Dis 12:127-9. 2008
    ..Follow-up of patients reported in the literature has been too short to provide a consensus in regard to the extent of surgery required to provide permanent cure...
  6. ncbi A female infant with Silver Russell Syndrome, mesocardia and enlargement of the clitoris
    Assimina Galli-Tsinopoulou
    4th Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Greece
    Hormones (Athens) 7:77-81. 2008
    ..We present a female infant with SRS, cardiac malposition and asymmetric enlargement of the clitoris. She is the first child of Greek nonconsanguinous parents, born at 38 weeks gestation, following in vitro ..
  7. pmc Clitoral sexual arousal: neuronal tracing study from the clitoris through the spinal tracts
    Nieves Martin-Alguacil
    Department of Neurobiology and Behavior, Rockefeller University, New York, New York, USA
    J Urol 180:1241-8. 2008
    ..specific afferent neural pathways transmit sensory stimuli of arousal, beginning at the epithelial level on the clitoris and following the course of arousal stimuli through the central nervous system...
  8. ncbi Duplication and exstrophy of the bladder with clitoris and vagina duplex as well as uterus bicornis
    Wolfram Kluwe
    Department of Surgical Pediatrics, Children s Hospital, Inselspital, University of Bern, Bern, Switzerland
    Urology 70:591.e1-2. 2007
    ..The surgical treatment, aiming at anatomic reconstruction of the genitourinary system and closure of the symphysis, was successfully performed without any complication...
  9. ncbi Malignant rhabdoid tumor of the clitoris in an elderly patient: report of a case
    D Haidopoulos
    1st Department of Obstetrics and Gynecology, University of Athens, Alexandra Hospital, Greece
    Eur J Gynaecol Oncol 23:447-9. 2002
    ..We report a case of malignant rhabdoid tumor of the clitoris occurring in an elderly patient...
  10. doi Neuroanatomical evidence for a role of central melanocortin-4 receptors and oxytocin in the efferent control of the rodent clitoris and vagina
    Helene Gelez
    Pelvipharm Laboratories, Orsay Parc, Bâtiment Cèdres, Orsay, France
    J Sex Med 7:2056-67. 2010
    The clitoris and the vagina are the main peripheral anatomical structures involved in physiological changes related to sexual arousal and orgasm...
  11. ncbi Anatomical study of the obturator foramen and dorsal nerve of the clitoris and their relationship to minimally invasive slings
    Chahin Achtari
    Urogynaecology Department, Mercy Hospital for Women, Clarendon Street, East Melbourne, 3002, Victoria, Australia
    Int Urogynecol J Pelvic Floor Dysfunct 17:330-4. 2006
    The objective of the study is to clarify potential risks to the dorsal nerve of the clitoris (DNC) and obturator canal using different minimally invasive slings.
  12. ncbi Rhabdomyosarcoma of the clitoris
    Neil D Ghushe
    Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Pediatr Radiol 37:1179. 2007
  13. ncbi Clitoral pain: the great unexplored pain in women
    Allan S Gordon
    Wasser Pain Management Centre, Mount Sinai Hospital, 600 University Avenue, 1170, Toronto, Ontario M5G 1X5, Canada
    J Sex Marital Ther 28:123-8. 2002
    ..Eight claimed painful, allodynic nipples and seven had sensitive nipples. Clitoral pain was an important cause of pain in these women...
  14. ncbi Peptidergic innervation of the human clitoris
    C Hauser-Kronberger
    Institute of Pathological Anatomy, Immunohistochemistry and Biochemistry Unit, University of Salzburg, Austria
    Peptides 20:539-43. 1999
    In the present study, the distributions of neuropeptides in the normal human clitoris and in a clitoris from an adrenogenital syndrome (AGS) was demonstrated by immunohistochemistry (IHC)...
  15. ncbi The anterior vaginal wall as an organ for the transmission of active forces to the urethra and the clitoris
    A Ingelman-Sundberg
    Sabbatsberg Hospital, Karolinska Institute, Stockholm, Sweden
    Int Urogynecol J Pelvic Floor Dysfunct 8:50-1. 1997
    ..It also functions during intercourse to transmit the effect of penile introduction into the vagina to the clitoris, by stretching the two ligaments that insert around its base.
  16. ncbi Menstrual cycle-related morphometric and vascular modifications of the clitoris
    Cesare Battaglia
    Department of Obstetrics and Gynaecology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Sex Med 5:2853-61. 2008
    ..The evaluation of clitoral anatomy and function is of paramount importance to understand the physiology and pathology of clitoral function...
  17. ncbi Effects of estrogen on nitric oxide synthase and histological composition in the rabbit clitoris and vagina
    H N Yoon
    Department of Urology, Medical Research Center, Seoul, Korea
    Int J Impot Res 13:205-11. 2001
    We investigated the functional and histological changes after oophorectomy in the rabbit clitoris and vagina to determine the mechanism responsible for the development of arousal disorder in postmenopausal women...
  18. ncbi Nevus lipomatosus cutaneous superficialis of the clitoris
    Ryo Hattori
    Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita Shi, Japan
    Dermatol Surg 29:1071-2. 2003
    Nevus lipomatosus cutaneous superficialis (NLCS) is a relatively rare condition. Although NLCS can affect any region of the entire body, no case of NLCS in the clitoris has ever been reported.
  19. ncbi Do women with female ejaculation have detrusor overactivity?
    Rufus Cartwright
    King s College Hospital, London, UK
    J Sex Med 4:1655-8. 2007
    ..Questionnaire surveys suggest that 40-54% of women have experienced an expulsion of fluid at orgasm. Some of these women have coital incontinence, whereas others identify the fluid passed as female ejaculate...
  20. doi Clitoral variability compared with penile variability supports nonadaptation of female orgasm
    Kim Wallen
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Evol Dev 10:1-2. 2008
  21. ncbi Feminizing genital reconstruction: experience with 52 cases of ambiguous genitalia
    A Al-Bassam
    Division of Pediatric Surgery, Department of Surgery, King Khalid University Hospital, Riyadh, Saudi Arabia
    Eur J Pediatr Surg 14:172-8. 2004
    ..In this report, we describe our experience with a total of fifty-two cases of ambiguous genitalia. We understand that this comes in the midst of growing criticism of the Hendren's procedure...
  22. ncbi Type of mutation and surgical procedure affect long-term quality of life for women with congenital adrenal hyperplasia
    Agneta Nordenskjold
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 93:380-6. 2008
    ..In congenital adrenal hyperplasia (CAH) caused by different mutations, feminizing surgery is mostly performed in childhood, and many patients are lost to follow-up...
  23. ncbi Sexual function in women with complete androgen insensitivity syndrome
    Catherine L Minto
    The Middlesex Clinic, Elizabeth Garrett Anderson Hospital, University College London Hospitals, London, United Kingdom
    Fertil Steril 80:157-64. 2003
    ..To investigate sexual function in women with complete androgen insensitivity syndrome (CAIS) and to investigate the prevalence of factors that might contribute to sexual difficulties...
  24. ncbi New techniques in female pudendal somatosensory evoked potential testing
    C C Yang
    Department of Urology, University of Washington, Seattle, 98195 6510, USA
    Somatosens Mot Res 21:9-14. 2004
    The primary nerves innervating the female genitalia are the dorsal nerve of the clitoris (DNC) and the perineal nerve, which innervate the clitoris and the external genitalia/distal vagina, respectively...
  25. ncbi Intersex surgery in the adult
    C R J Woodhouse
    The Institute of Urology and Nephrology, University College London, and The Hospital for Children, Great Ormond Street, London, UK
    BJU Int 93:57-65. 2004
  26. ncbi Morphological modifications in clitoris and vagina in spontaneously hypertensive rats
    A J Bechara
    Sexual Dysfunction Section, Urology Division, Hospital Durand, Buenos Aires, Argentina
    Int J Impot Res 15:166-72. 2003
    We evaluated possible morphological alteration in clitoris and vagina from spontaneous hypertensive rats (SHR) and normotensive WKY rats...
  27. ncbi Feminizing genitoplasty in adult transsexuals: early and long-term surgical results
    Jonathan C Goddard
    Department of Urology, University Hospitals of Leicester NHS Trust, Leicester, UK
    BJU Int 100:607-13. 2007
    ..To examine the early and late surgical outcomes of feminizing genitoplasty (FG) in adult transsexuals in a UK single surgeon practice over a 10-year period...
  28. ncbi Genital sensation after feminizing genitoplasty for congenital adrenal hyperplasia: a pilot study
    N S Crouch
    Department of Obstetrics and Gynaecology, Elizabeth Garrett Anderson and Obstetric Hospital, University College London Hospitals, London, UK
    BJU Int 93:135-8. 2004
    To assess sensation in the clitoris and vagina in women with congenital adrenal hyperplasia (CAH) who have previously had genital surgery, and to evaluate sexual function in this group as the latter, and particularly the experience of ..
  29. ncbi Success of sildenafil treatment in neurogenic female sexual dysfunction caused by L5-S1 intervertebral disk rupture: a case report
    Dean Ferrara
    Ohio University College of Osteopathic Medicine, Athens, Ohio, USA
    Int J Urol 14:566-7; discussion 568. 2007
    ..Physiologic sexual dysfunction can, in many cases, be the result of impaired neurovascular tone to the clitoris and vagina. The vagina and clitoris both contain erectile tissue and phosphodiesterase type 5 (PDE5)...
  30. ncbi Labioscrotal island flap in feminizing genitoplasty
    Marcio Lopes Miranda
    Division of Pediatric Surgery and Pediatric Endocrinology, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    J Pediatr Surg 39:1030-3. 2004
    ..With the aim of enlarging the vaginal introitus, the authors present a technical modification of the introitoplasty that uses a bilateral cutaneous island flap based on the perineal superficial branches of the internal pudendal artery...
  31. ncbi Feminizing surgical management of intersex patients
    E Eroglu
    Section of Pediatric Surgery, VKF American Hospital, Istanbul, Turkey
    Pediatr Surg Int 20:543-7. 2004
    ..Eight of the postpubertal patients asked questions about their reproductive status. Patients with an intersex disorder should be informed about their problems, especially about their reproductivity...
  32. pmc Identification of neural circuits involved in female genital responses in the rat: a dual virus and anterograde tracing study
    L Marson
    Division of Urology, Department of Surgery, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Am J Physiol Regul Integr Comp Physiol 291:R419-28. 2006
    The spinal and peripheral innervation of the clitoris and vagina are fairly well understood. However, little is known regarding supraspinal control of these pelvic structures...
  33. ncbi Colpoperineoplasty in women with a sensation of a wide vagina
    Jack S Pardo
    Department of Obstetrics and Gynecology, Clinica Las Condes, Santiago, Las Condes, Chile
    Acta Obstet Gynecol Scand 85:1125-7. 2006
    ..In women complaining of a wide vagina and decreased sexual satisfaction we performed colporrhaphy--including perineoplasty in most cases...
  34. ncbi Genital sensation and sexual function in women bicyclists and runners: are your feet safer than your seat?
    Marsha K Guess
    Albert Einstein College of Medicine Montefiore Medical Center, Bronx, NY, USA
    J Sex Med 3:1018-27. 2006
    ..Bicycling is associated with neurological impairment and impotence in men. Similar deficits have not been confirmed in women...
  35. ncbi Feminising genitoplasty: one-stage genital reconstruction in congenital adrenal hyperplasia: 30 years' experience
    M F Roll
    Department of Paediatric Surgery, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Eur J Pediatr Surg 16:329-33. 2006
    ..the importance of short and long-term follow-up results with respect to appearance, position and size of the clitoris and quality of the vagina...
  36. ncbi Sexual dysfunction in women with diabetes mellitus
    Derek Rutherford
    Department of Urology, Ayr Hospital, UK
    Gynecol Endocrinol 21:189-92. 2005
    ..Previous studies in women with diabetes may also neglect the importance of the subjective qualities associated with female sexuality and sexual expression...
  37. ncbi Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals
    Gennaro Selvaggi
    Department of Plastic Surgery, University Hospital of Ghent, Ghent, Belgium
    Plast Reconstr Surg 116:135e-145e. 2005
    ..3. The surgical goals of sex reassignment surgery in male-to-female transsexualism. 4. The surgical techniques available for sex reassignment surgery in male-to-female transsexualism...
  38. pmc Case of hermaphrodism, involving the operation of castration and illustrating a new principle of juridical medicine
    S D Gross
    Medical Department of the University of Louisville, Louisville, Kentucky, USA
    Yale J Biol Med 76:129-32. 2003
  39. ncbi Neuropeptide receptor transcripts are expressed in the rat clitoris and oscillate during the estrus cycle in the rat vagina
    David Dangoor
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Einstein Street, 69978 Tel Aviv, Israel
    Peptides 26:2579-84. 2005
    ..receptor mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) in the rat vagina and clitoris, and alteration during the shift from the proestrus to the estrus phase...
  40. pmc Clitoral anatomy in nulliparous, healthy, premenopausal volunteers using unenhanced magnetic resonance imaging
    Helen E O'Connell
    Department of Surgery, University of Melbourne, Parkville, Victoria, Australia
    J Urol 173:2060-3. 2005
    ..We determined the magnetic resonance imaging (MRI) characteristics of normal clitoral anatomy...
  41. ncbi Genital sensitivity after sex reassignment surgery in transsexual patients
    Gennaro Selvaggi
    Department of Plastic Surgery, Ghent University Hospital, Gent, Belgium
    Ann Plast Surg 58:427-33. 2007
    ..In phalloplasty, the dorsal hood of the clitoris is incorporated into the neoscrotum; the clitoris is transposed, buried, and fixed directly below the ..
  42. ncbi Long-term functional outcomes of female genital reconstruction in childhood
    Naomi S Crouch
    Department of Obstetrics and Gynaecology, University College Hospital, London, UK
    BJU Int 100:403-7. 2007
    ....
  43. ncbi [Current plastic surgery in abnormalities of female genitalia]
    Lieselotte Frost-Arner
    Plastikkirurgiska kliniken, Universitetssjukhuset MAS, Malmo
    Lakartidningen 101:2894-8, 2900. 2004
  44. ncbi Physiological changes in female genital sensation during sexual stimulation
    Ilan Gruenwald
    Rambam Medical Center Neuro urology, Haifa, Israel
    J Sex Med 4:390-4. 2007
    ..So far genital sensation has been investigated only during a non-excitatory state, and the sensory physiological changes, which occur during the sexual cycle in this region, are still obscured...
  45. ncbi Development of feminizing genitoplasty for gender dysphoria
    Jonathan Charles Goddard
    Department of Urology, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Gwendolen Road, Leicester, UK
    J Sex Med 4:981-9. 2007
    ..Gender reassignment surgery (GRS) developed from reconstructive procedures for congenital abnormalities. Some surgery was disguised, techniques were not recorded, and operations were carried out in secret...
  46. ncbi Self-assessment of genital anatomy, sexual sensitivity and function in women: implications for genitoplasty
    Justine M Schober
    Paediatric Urology, Hamot Medical Center, Erie, PA, USA
    BJU Int 94:589-94. 2004
    ....
  47. ncbi Adrenocorticotropic hormone and 17-hydroxyprogesterone levels during high-dose glucocorticoid supplement for the management of clitoroplasty of CYP21A2 deficiency
    Yasuhiro Naiki
    Division of Endocrinology and Metabolism, National Center of Child Health and Development, Setagaya, Tokyo 157 8535, Japan
    Endocr J 51:367-73. 2004
    ..ACTH and 17OHP levels were completely suppressed throughout operation, indicating that this kind of additional pretreatment is more effective approach...
  48. ncbi Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides
    David C Pryde
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    J Med Chem 49:4409-24. 2006
    ..This led ultimately to the prototype development candidate R-13, for which detailed pharmacology and pharmacokinetic parameters are presented.(1)..
  49. ncbi The long term outcome of feminizing genital surgery for congenital adrenal hyperplasia: anatomical, functional and cosmetic outcomes, psychosexual development, and satisfaction in adult female patients
    Nike M M L Stikkelbroeck
    Departments of Pediatric Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pediatr Adolesc Gynecol 16:289-96. 2003
    ..There are only a few reports analyzing the long term outcome of feminizing surgery in females with congenital adrenal hyperplasia (CAH). Such analysis is crucial to evaluate the treatment and to make necessary adjustments...
  50. ncbi Female genitalia: dynamic MR imaging with use of MS-325 initial experiences evaluating female sexual response
    Anastasia V Deliganis
    Departments of Radiology, University of Washington, 1959 NE Pacific St, Box 357115, Seattle, WA 98195 7115, USA
    Radiology 225:791-9. 2002
    ..To determine whether magnetic resonance (MR) imaging with MS-325, a recently developed blood pool contrast agent, can depict sexual arousal response in healthy women...
  51. ncbi Effects of ovariectomy and estrogen and androgen treatment on sildenafil-mediated changes in female genital blood flow and vaginal lubrication in the animal model
    Kweonsik Min
    Department of Biochemistry, Boston University School of Medicine, Mass, USA
    Am J Obstet Gynecol 187:1370-6. 2002
    ..Our purpose was to investigate the effects of ovariectomy and estradiol and testosterone treatment on sildenafil- induced changes in genital hemodynamics and vaginal lubrication...
  52. doi Clitoral and penile size variability are not significantly different: lack of evidence for the byproduct theory of the female orgasm
    Vincent J Lynch
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511, USA
    Evol Dev 10:396-7. 2008
  53. ncbi The impact of aging on sexual function in women and their partners
    Sheryl A Kingsberg
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio 44106, USA
    Arch Sex Behav 31:431-7. 2002
    ..It is also essential to understand how the physiological changes in female as well as male sexual functioning impact desire. Further, other health-related changes that occur with aging must be recognized and addressed...
  54. doi Inappropriate comparisons and the weakness of cryptic choice: a reply to Vincent J. Lynch and D. J. Hosken
    Kim Wallen
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Evol Dev 10:398-9. 2008
  55. ncbi Type 5 phosphodiesterase expression in the human vagina
    Giulia D'amati
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy
    Urology 60:191-5. 2002
    ..Considering the role of the vagina in the female sexual response and the anatomic connection between the clitoris and the anterosuperior vaginal wall, our aim was to study the distribution of type 5 phosphodiesterase (PDE5) in ..
  56. ncbi Severity of virilization of external genitalia in Japanese patients with salt-wasting 21-hydroxylase deficiency
    Yukari Sugiyama
    Department of Pediatrics, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan
    Tohoku J Exp Med 215:341-8. 2008
    ..The degree of the impairment of 21-hydroxylase activity does not correlate with the severity of virilization of the external genitalia in female patients with the SW type of 21OHD...
  57. ncbi Female sexual dysfunction
    J R Berman
    Center for Female Sexual Medicine, Department of Urology, University of California Los Angeles Medical Center, Los Angeles, California, USA
    Urol Clin North Am 28:405-16. 2001
    ....
  58. ncbi Functional anatomy of the human vagina
    G D'amati
    Department of Experimental Medicine and Pathology, 1st University of Rome, La Sapienza, Rome, Italy
    J Endocrinol Invest 26:92-6. 2003
    ..biochemical and molecular regulation of erection are largely known, the exact anatomical description of the human clitoris was produced in 1998, the taxonomy of female sexual dysfunctions classified in 1999, and biochemistry of female ..
  59. ncbi Neurophysiology and pharmacology of female genital sexual response
    Francois Giuliano
    Groupe de Recherche en Urologie, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    J Sex Marital Ther 28:101-21. 2002
    ..Autonomic preganglionic parasympathetic and inhibitory sympathetic fibers to the vagina and clitoris originate in the spinal cord in the sacral parasympathetic nucleus at the sacral level and in the dorsal gray ..
  60. ncbi Experimental models for the investigation of female sexual function and dysfunction
    K Min
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 13:151-6. 2001
    ..An in vivo animal model was developed to record physiological and hemodynamic changes in the clitoris and vagina following pelvic nerve stimulation and administration of vasoactive agents and physiological ..
  61. ncbi A new non-pharmacological vacuum therapy for female sexual dysfunction
    K L Billups
    University of Minnesota, Minneapolis, Minnesota, USA
    J Sex Marital Ther 27:435-41. 2001
    ..EROS-CTD is a small, battery-powered device designed to enhance clitoral engorgement, increase blood flow to the clitoris, and ultimately improve arousal in women with FSD...
  62. pmc The Rho-kinase inhibitor Y-27632 and the soluble guanylyl cyclase activator BAY41-2272 relax rabbit vaginal wall and clitoral corpus cavernosum
    Selim Cellek
    Wolfson Institute for Biomedical Research, University College London, Gower Street, Cruciform Building, London WC1E 6BT
    Br J Pharmacol 138:287-90. 2003
    ..Y-27632 had no effect on nitrergic relaxations in either tissue. These results demonstrate that Y-27632 and BAY41-2272 elicit relaxation of the rabbit vaginal wall and clitoral corpus cavernosum...
  63. ncbi Arousal disorders in women: complaints and complexities
    Sandra R Leiblum
    UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Med J Aust 178:638-40. 2003
    ..There may be a place for drugs that increase vasocongestion and vasodilation. Psychological therapy addresses inhibitions, and interpersonal and motivational factors...
  64. ncbi Magnetic resonance imaging anatomy of the female genitalia in premenopausal and postmenopausal women
    Donald D Suh
    Department of Urology, University of Washington, Box 356510, 1959 NW Pacific Street, Seattle, WA 98195 6510, USA
    J Urol 170:138-44. 2003
    ..We used contrast enhanced magnetic resonance imaging (MRI) of the female genital organs to describe normal anatomy and differences between premenopausal and postmenopausal women...
  65. ncbi Vardenafil enhances clitoral and vaginal blood flow responses to pelvic nerve stimulation in female dogs
    J Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Int J Impot Res 15:137-41. 2003
    The relaxation of the smooth muscle in the vagina and clitoris and the increase of blood flow into these organs is thought to be essential in the female sexual response...
  66. doi 3-dimensional neuroanatomy of the human fetal pelvis: anatomical support for partial urogenital mobilization in the treatment of urogenital sinus
    Nicolas Kalfa
    Center for Study and Treatment of Hypospadias, Department of Urology, University of California San Francisco Children s Medical Center, University of California San Francisco, San Francisco, California 94143, USA
    J Urol 180:1709-14; discussion 1714-5. 2008
    ..A precise understanding of pelvic fetal neuroanatomy is germane for optimizing surgical correction of the urogenital sinus...
  67. ncbi Do women gain anything from coitus apart from pregnancy? Changes in the human female genital tract activated by coitus
    R J Levin
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    J Sex Marital Ther 29:59-69. 2003
    ..I conclude that apart from the normal erotic pleasure, women gain and maintain vaginal and pelvic functionality from these and, subsequently, from coitus...
  68. ncbi True hermaphroditism: clinical features, genetic variants and gonadal histology
    N Yordam
    Department of Pediatrics, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey
    J Pediatr Endocrinol Metab 14:421-7. 2001
    ..Five patients were assigned to the female sex, and three to the male sex. One of these patients was changed from male to female after evaluation...
  69. ncbi Ultrastructural effect of sildenafil citrate on corpus cavernosum and other genital organs in female rats
    K Kilinc
    Department of Urology, Medical Faculty, Celal Bayar University, 45010 Manisa, Turkey
    Asian J Androl 5:37-41. 2003
    ..To determine the ultrastructural effects of sildenafil on the female genital organs...
  70. ncbi Total urogenital sinus mobilization: a modified perineal approach for feminizing genitoplasty and urogenital sinus repair
    R Jenak
    University of Miami, Miami, Florida, and Landeskrankenanstalten, Salzburg, Austria
    J Urol 165:2347-9. 2001
    ..long can be accomplished with total urogenital sinus mobilization through the perineal approach. The technique can be combined with reduction clitoroplasty for the surgical management of girls with masculinized external genitalia...
  71. ncbi Feminizing genitoplasty
    Terry W Hensle
    Columbia University, College of Physicians and Physicians, Department of Urology, Division of Pediatric Urology, Babies and Children s Hospital of New York, New York, NY, USA
    Adv Exp Med Biol 511:251-65; discussion 265-6. 2002
  72. ncbi Total urogenital sinus mobilization in the repair of cloacal anomalies and congenital adrenal hyperplasia
    A F Hamza
    Ain Shams University, Cairo, Egypt
    J Pediatr Surg 36:1656-8. 2001
    ..The improved cosmetic appearance and the absence of vaginal stenosis provided by this technique is a major advantage in the management of these difficult surgical situations...
  73. ncbi Urogenital system of the spotted hyena (Crocuta crocuta Erxleben): a functional histological study
    Gerald R Cunha
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    J Morphol 256:205-18. 2003
    ..to identify adaptations of "structure" that enable/facilitate urination, mating, and parturition through the clitoris. Unusual features of penile anatomy required for meeting ceremonies and successful mating through a clitoral ..
  74. pmc Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice
    Ruey Sheng Wang
    Department of Pathology and Urology, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endocr Rev 30:119-32. 2009
    ..total AR knockout mice exhibited female-typical external appearance (including a vagina with a blind end and a clitoris-like phallus), the testis was located abdominally, and germ cell development was severely disrupted, which was ..
  75. ncbi A posterior-based omega-shaped flap vaginoplasty in girls with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency
    L G Freitas Filho
    Paediatric Urology, Hospital Infantil Darcy Vargas, Rua Batista Cepelos 87 Ap 61, 04109 120 São Paulo, Brazil
    BJU Int 91:263-7. 2003
    ....
  76. ncbi A novel missense mutation of 5-alpha reductase type 2 gene (SRD5A2) leads to severe male pseudohermaphroditism in a Turkish family
    Mithat Bahceci
    Department of Endocrinology, University of Dicle, School of Medicine, Diyarbakir, Turkey
    Urology 66:407-10. 2005
    ..To analyze the steroid 5-alpha reductase type 2 gene (SRD5A2) in 2 siblings with severe male pseudohermaphroditism suspected to have 5-alpha reductase deficiency in a Turkish family...
  77. ncbi Sexual differentiation in three unconventional mammals: spotted hyenas, elephants and tammar wallabies
    Stephen E Glickman
    Department of Psychology, University of California, Berkeley, California 94720, USA
    Horm Behav 48:403-17. 2005
    ..to pregnant female spotted hyenas does not prevent the formation of a scrotum, pseudoscrotum, penis or penile clitoris in the offspring of treated females, although it is not yet clear whether the creation of masculine genitalia ..
  78. ncbi Therapeutic value of trichloroacetic acid in the treatment of isolated genital warts on the external female genitalia
    Zeki M Taner
    Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey
    J Reprod Med 52:521-5. 2007
    ..To evaluate the value of 85% trichloroacetic acid (TCA) in the treatment of human papillomavirus (HPV)-associated genital warts of the external genitalia and to detect the recurrence rate and side effects of this therapeutic regimen...
  79. doi Relaxin concentrations in serum and urine of endangered and crazy mixed-up species
    B Steinetz
    Department of Environmental Medicine, NYU School of Medicine, Tuxedo, New York 10987, USA
    Ann N Y Acad Sci 1160:179-85. 2009
    ..be extinct were it not for the timely secretion of relaxin to enable copulation and birth of young through the clitoris. Additional studies have suggested relaxin may be a useful marker of pregnancy in the northern fur seal and the ..
  80. ncbi [Effect of acupuncture of different acupoints on electrical activities of hypothalamic sexual arousal stimulation-related neurons at different stages of oestrous cycle in rats]
    Shao Jun Wang
    Institute of Acu moxibustion, Chana Academy of Chinese Medical Sciences, Beijing 100700, China
    Zhen Ci Yan Jiu 32:313-8. 2007
    ....
  81. ncbi Two cases with interstitial deletions of chromosome 2 and sex reversal in one
    A Slavotinek
    University Department of Medical Genetics, St Mary s Hospital, Manchester, United Kingdom
    Am J Med Genet 86:75-81. 1999
    ..Despite her male karyotype, she had female external genitalia with hypoplasia of the clitoris and labia minora...
  82. ncbi Female gonad of moles, genus Talpa (Insectivora, mammalia): ovary or ovotestis?
    F Beolchini
    Department of Animal Biology, University of Modena and Reggio Emilia, 41100 Modena, Italy
    J Exp Zool 286:745-54. 2000
    ..apparatus there are masculine glandular annexes, such as a bilobate prostate, two Cowper glands, and a penis-like clitoris. All these features have recently led to the hypothesis of the presence of hermaphroditism due to sex-reversal in ..
  83. ncbi Lifetime changes in the vulva and vagina
    Miranda Farage
    The Procter and Gamble Company, Feminine Care Clinical Sciences, Winton Hill Technical Center, 6110 Center Hill Rd, Box 136, Cincinnati, OH 45224, USA
    Arch Gynecol Obstet 273:195-202. 2006
    ..The cutaneous epithelia of the mons pubis, labia, and clitoris originate from the embryonic ectoderm and exhibit a keratinized, stratified structure similar to the skin at ..
  84. ncbi Restless genital syndrome before and after clitoridectomy for spontaneous orgasms: a case report
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, 2545 CH The Hague, The Netherlands
    J Sex Med 7:1029-34. 2010
    ..Females despairing of restless genital syndrome (ReGS) may request clitoridectomy for treatment of unwanted genital sensations. Aim. The aim of this study was to report persistence of ReGS despite clitoridectomy...
  85. ncbi [Sexuality of pregnant women]
    Andrzej Malarewicz
    Zakład Perinatologii Instytutu Kształcenia Medycznego Akademii Swietokrzyskiej w Kielcach
    Ginekol Pol 77:733-9. 2006
    ..Pregnant women prefer the following types of sexual activity: non-genital fondling, stimulation of the clitoris, vagina and breasts, oral and anal stimulation and masturbation...
  86. ncbi Transient genital abnormalities in striped hyenas (Hyaena hyaena)
    Aaron P Wagner
    Department of Ecology, Montana State University, Bozeman, MT 59717, USA
    Horm Behav 51:626-32. 2007
    ..mammals: Crocuta have no external vagina so urination, penile intromission and parturition take place through the clitoris, which mimics a fully erectile male penis...
  87. ncbi A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom)
    F A Conte
    Department of Pediatrics, University of California, San Francisco 94143 0106
    J Clin Endocrinol Metab 78:1287-92. 1994
    ..By 14 yr of age, she had failed to exhibit breast development. The clitoris had enlarged to 4 x 2 cm, and pubic hair was Tanner stage IV...
  88. ncbi Hypogonadism and pubertal development in Prader-Willi syndrome
    A Crino
    Unit of Autoimmune Endocrine Diseases, Pediatric Endocrinology Dept, Bambino Gesu Children s Hospital, Scientific Institute, Piazza S Onofrio, 4 00165, Rome, Italy
    Eur J Pediatr 162:327-33. 2003
    ..scrotal development, length of penis and volume of testis in males and outlook of labia minora and/or clitoris, age of menarche and features of menses (when present) in females; in both sexes we also evaluated the onset of ..
  89. doi Hodgkin lymphoma presenting as a vulvar mass in a patient with crohn disease: a case report and literature review
    Monika Winnicki
    Department of Dermatology, CHUM Saint Luc Hospital, University of Montreal, Montreal, Quebec, Canada
    J Low Genit Tract Dis 13:110-4. 2009
    ..A case of Hodgkin lymphoma of the vulva and perineum is presented along with a review of the literature...
  90. ncbi Granulocytic sarcoma of the ovotestis: an association of myelodysplastic syndrome and hermaphroditism
    Zahit Bolaman
    Department of Hematology, Faculty of Medicine, Adnan Menderes University, Aydin 09100, Turkey
    Leuk Lymphoma 45:1285-7. 2004
    ..Breast development was grade II. There was no clitoris hypertrophy. Her labia majora were separate and vagina hypoplastic. Hemoglobin level was 9...
  91. ncbi [Abnormalities of external and internal genitalia]
    Sabine Anthuber
    Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe, Klinikum der Ludwig Maximilians Universität München Grosshadern, Munich, Germany
    Gynakol Geburtshilfliche Rundsch 43:136-45. 2003
    ..of a child's hymenal membrane, fusion of the labia minora, hymenal polyps and hypertrophy of the preputium of the clitoris are the entities most likely to be mistaken for real developmental malformations...
  92. ncbi A case of freemartin with atresia recti and ani in Japanese Black calf
    Mohamed Elshabrawy Ghanem
    Laboratory of Animal Science, Graduate School for International Development and Cooperation, Hiroshima University, 1 5 1 Kagamiyama, Higashi Hiroshima 739 8529, Japan
    Anim Reprod Sci 85:193-9. 2005
    ..A small opening to the vulva (about 1.5 cm in length) with fused lips and a prominent clitoris were seen. The hair around the vulva was 3.5 cm in length and was heavy and dense...
  93. ncbi [Clinical analysis of 6 cases with atypical vulvovaginal malformations]
    Shu Wang
    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Fu Chan Ke Za Zhi 44:263-7. 2009
    ..To investigate clinical features and management of complicated or rare vulvovaginal anomalies derived from urogenital sinus malformation...
  94. ncbi The neurophysiology of the sexual cycle
    A Argiolas
    Bernard B Brodie Department of Neuroscience, Cittadella Universitaria, University of Cagliari, Sestu Monserrato, Italy
    J Endocrinol Invest 26:20-2. 2003
    ..and ejaculation (orgasm), whereas female sexual activity is characterized by vaginal lubrication, erection of the clitoris and orgasm. These responses are under the control of numerous central and peripheral neural systems...
  95. ncbi Phosphodiesterase inhibitors in female sexual dysfunction
    Margit Mayer
    Department of Urology, Faculty of Medicine, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    World J Urol 23:393-7. 2005
    ..The expression of various PDE isoforms in the human clitoris, vagina and labia minora was shown by means of immunohistochemistry and RT-PCR analyses and it was concluded from ..
  96. ncbi Convergence of nociceptive information in the forebrain of female rats: reproductive organ response variations with stage of estrus
    Harpreet K Chadha
    Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 210:375-87. 2008
    ..e., dorsal nerve of clitoris)...
  97. ncbi Cellular angiofibroma of the vulva: a clinicopathological study of two cases with documentation of some unusual features and review of the literature
    Jean Louis Dargent
    Department of Pathology, CHU Saint Pierre Institut Jules Bordet, Brussels, Belgium
    J Cutan Pathol 30:405-11. 2003
    ..Cellular angiofibroma (CA) of the vulva is a recently described condition, whose clinical and pathological features are poorly known...
  98. ncbi Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females
    Louis J G Gooren
    Department of Endocrinology, Andrology Unit, VU University Medical Center, Amsterdam, The Netherlands
    J Sex Med 5:765-76. 2008
    ..Naturally, androgens may have virilizing effects in women. It is often believed that androgens have deleterious effects on cardiovascular risks...
  99. doi Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development
    Chi Huang Chen
    Department of Obstetrics and Gynecology, Tri Service General Hospital, National Defense Medical Center, Taiwan
    Fertil Steril 91:2732.e5-7. 2009
    ..To present male gender preselection after successive gestational hyperandrogenism and female pseudohermaphroditism by pregnancy luteomas...
  100. ncbi Characteristics of external genitalia in pre- and postmenopausal women
    M Basaran
    Department of Obstetrics and Gynecology, University School of Medicine, Zonguldak, Turkey
    Climacteric 11:416-21. 2008
    ..To determine those objective measurements that characterize the differences between the external genital organs of pre- and postmenopausal women...
  101. ncbi Efficacy and safety of alprostadil cream for the treatment of female sexual arousal disorder: a double-blind, placebo-controlled study in chinese population
    Qinping Liao
    Department of Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, China
    J Sex Med 5:1923-31. 2008
    ..To date, no approved medication is available for the treatment of female sexual arousal disorder (FSAD)...

Research Grants70

  1. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
    ..experimental systems including: I) an in vivo animal model to record physiologic and hemodynamic changes in the clitoris and vagina following pelvic nerve stimulation, ii) in vitro organ baths of clitoral and vaginal tissue to ..
  2. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2001
    ..There is no external vagina. The clitoris has developed until it is the approximate size and shape of the male penis and is traversed by a central ..
  3. Testosterone dose response in surgically menopausal woment
    Shalender Bhasin; Fiscal Year: 2003
    ..However, we do not know whether the skin, hair, vocal cords, and clitoris differ in their testosterone sensitivity from sexual, cognitive, and physical functions...
  4. Hypospadias: Interactions of Sex Steroids and Fgfr2
    Martin Cohn; Fiscal Year: 2005
    ..either continued growth and differentiation of the penis, or arrest of outgrowth and differentiation of the clitoris. In all species studied to date, this second phase of male phallic development requires embryonic exposure to an ..
  5. Hypospadias: Interactions of Sex Steroids and Fgfr2
    Martin Cohn; Fiscal Year: 2006
    ..either continued growth and differentiation of the penis, or arrest of outgrowth and differentiation of the clitoris. In all species studied to date, this second phase of male phallic development requires embryonic exposure to an ..
  6. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2003
    ..The female spotted hyena has no external vagina. The clitoris has hypertrophied until it is the approximate size and shape of the male penis, and is traversed by a central ..
  7. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2006
    ..The female spotted hyena has no external vagina. The clitoris has hypertrophied until it is the approximate size and shape of the male penis, and is traversed by a central ..
  8. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2002
    ..The female spotted hyena has no external vagina. The clitoris has hypertrophied until it is the approximate size and shape of the male penis, and is traversed by a central ..
  9. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2000
    ..There is no external vagina. The clitoris has developed until it is the approximate size and shape of the male penis and is traversed by a central ..
  10. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2004
    ..The female spotted hyena has no external vagina. The clitoris has hypertrophied until it is the approximate size and shape of the male penis, and is traversed by a central ..
  11. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 1999
    ..There is no external vagina. The clitoris has developed until it is the approximate size and shape of the male penis and is traversed by a central ..
  12. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2005
    ..The female spotted hyena has no external vagina. The clitoris has hypertrophied until it is the approximate size and shape of the male penis, and is traversed by a central ..
  13. AUTONOMIC NERVOUS CONTROL OF ORGANS
    Masahito Kawatani; Fiscal Year: 1990
    ..and the peripheral and central organization of the neural pathways to different parts of the reproductive system (clitoris, uterine cervix, uterine horns)...
  14. The role of Sprouty genes in development of mammalian external genitalia
    Ophir D Klein; Fiscal Year: 2012
    ..molecules plays a central role in formation of the genital tubercle, which is the anlage of the glans penis and clitoris. Therefore, determining how the FGF pathway is regulated in the genital tubercle and which other pathways it ..
  15. Targets of Endocrine Disruptors in External Genitalia
    Martin J Cohn; Fiscal Year: 2010
    ..targets of EDCs and determining their functions in the genital tubercle (the embryonic anlagen of the penis and clitoris) is critical if we are to (a) understand the mechanisms by which EDCs perturb normal development, (b) understand ..
  16. Targets of Endocrine Disruptors in External Genitalia
    Martin J Cohn; Fiscal Year: 2010
    ..targets of EDCs and determining their functions in the genital tubercle (the embryonic anlagen of the penis and clitoris) is critical if we are to (a) understand the mechanisms by which EDCs perturb normal development, (b) understand ..
  17. Posttranslational Regulation of eNOS by Estrogen in the Vagina and Clitoris
    Biljana Musicki; Fiscal Year: 2006
    ..At the same time it may advance treatments for multiple disease states associated with endothelial dysfunction and alterations in hormonal milieu. [unreadable] [unreadable] [unreadable]..
  18. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2001
    ..experimental systems including: I) an in vivo animal model to record physiologic and hemodynamic changes in the clitoris and vagina following pelvic nerve stimulation, ii) in vitro organ baths of clitoral and vaginal tissue to ..
  19. UCSF KURe Career Development Program
    Laurence Baskin; Fiscal Year: 2008
    ..The goal of this KURe grant is to train future urologic surgeon and scientist leaders with the latest research tools so they can favorable impact patient care and improve health care outcomes. ..
  20. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2000
    ..experimental systems including: I) an in vivo animal model to record physiologic and hemodynamic changes in the clitoris and vagina following pelvic nerve stimulation, ii) in vitro organ baths of clitoral and vaginal tissue to ..
  21. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2002
    ..experimental systems including: I) an in vivo animal model to record physiologic and hemodynamic changes in the clitoris and vagina following pelvic nerve stimulation, ii) in vitro organ baths of clitoral and vaginal tissue to ..
  22. Genes Inducing Bladder Smooth Muscle Formation
    Laurence Baskin; Fiscal Year: 2007
    ....
  23. UROTHELIAL DIFFENTIATION
    Laurence Baskin; Fiscal Year: 2003
    ..Furthermore, we propose that abnormal epithelial-stroma signaling that occurs when intestinal segments are placed in contact with the bladder may lead to cellular changes such as atypia or even cancer. ..
  24. Hypospadias Differentiation and Endocrine Disruptors
    Laurence Baskin; Fiscal Year: 2005
    ..Ultimately preventative steps to decrease prenatal toxic exposure may be the must useful intervention with the mouse model providing a means to test suspected agents. ..
  25. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2002
    ..The combination of these efforts will allow the PI to expand his research into new areas, while increasing his understanding of its relevance to important human mental health conditions. ..
  26. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..These therapies will also be compared on their effects on neuroendocrine function. These studies will markedly increase our understanding of the role that ovarian steroids play in modulating women's sexuality. ..
  27. A Community Study of Infertility in Northern Tanzania
    Ulla Larsen; Fiscal Year: 2004
    ..A basic protocol for the recommended treatment of infertility will be developed. 6. To analyze the social implications of infertility. 7. To assess the demographic implications of infertility. ..
  28. BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2004
    ..This research extends and develops the notion that alterations in the prenatal androgen that leave no external indicators may produce life-long alterations in development and adult behavior. ..
  29. The Cleveland Clinic Clinical Site
    Matthew Barber; Fiscal Year: 2006
    ..A standardized common protocol for enrollment, treatment and data collection will be employed by 6-8 Clinical Sites within the PFDN coordinated by the data coordinating center. ..
  30. Amygdala: sex differences in behavior, cognition, and neuroendocrine development
    Kim Wallen; Fiscal Year: 2010
    ..These data will potentially reveal social deficits that would remain undetectable by traditional observation methods. ..
  31. Amygdala: sex differences in behavior, cognition, and neuroendocrine development
    Kim Wallen; Fiscal Year: 2010
    ....
  32. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ..abstract_text> ..
  33. Amygdala: sex differences in behavior, cognition, and neuroendocrine development
    Kim Wallen; Fiscal Year: 2008
    ....
  34. The Cleveland Clinic Clinical Site
    Matthew Barber; Fiscal Year: 2008
    ..A standardized common protocol for enrollment, treatment and data collection will be employed by 6-8 Clinical Sites within the PFDN coordinated by the data coordinating center. ..
  35. Integrated Training in Psychobiology and Psychopathology
    Kim Wallen; Fiscal Year: 2008
    ..Clinical trainees will get the opportunity to delve more deeply into the basic science underlying psychopathology while basic science trainees will come to understand the relationship between basic science and human mental illness. ..
  36. Amygdala: sex differences in behavior, cognition, and neuroendocrine development
    Kim Wallen; Fiscal Year: 2007
    ....
  37. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ....
  38. eNOS-Protein Interaction in the Penis
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time, it may suggest a specific eNOS regulatory pathway as a possible new molecular target for treating ED. [unreadable] [unreadable] [unreadable]..
  39. The Cleveland Clinic Clinical Site
    Matthew Barber; Fiscal Year: 2007
    ..A standardized common protocol for enrollment, treatment and data collection will be employed by 6-8 Clinical Sites within the PFDN coordinated by the data coordinating center. ..
  40. Integrated Training in Psychobiology and Psychopathology
    Kim Wallen; Fiscal Year: 2007
    ..Clinical trainees will get the opportunity to delve more deeply into the basic science underlying psychopathology while basic science trainees will come to understand the relationship between basic science and human mental illness. ..
  41. A Community Study of Infertility in Northern Tanzania
    Ulla Larsen; Fiscal Year: 2004
    ..A basic protocol for the recommended treatment of infertility will be developed. 6. To analyze the social implications of infertility. 7. To assess the demographic implications of infertility. ..
  42. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2000
    ..abstract_text> ..
  43. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 1999
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  44. SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 1999
    ..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
  45. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 1999
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
  46. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 1999
    ....
  47. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 1999
    ..abstract_text> ..
  48. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 2000
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  49. Stromal Epithelial Interactions in Breast Cancer
    Gerald Cunha; Fiscal Year: 2004
    ..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
  50. BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2003
    ..This research extends and develops the notion that alterations in the prenatal androgen that leave no external indicators may produce life-long alterations in development and adult behavior. ..
  51. Stromal Epithelial Interactions in Breast Cancer
    Gerald Cunha; Fiscal Year: 2003
    ..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
  52. Calorie Restriction Effects on Chromosomal Aberrations
    CHARLEEN MOORE; Fiscal Year: 2003
    ..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..
  53. Towards renal regeneration
    Melissa Little; Fiscal Year: 2002
    ..Human ES cell work will be performed using ES01, 02, 03, 04, 05 & 06 listed on the NIH ES cell line registry. ..
  54. BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2001
    ..This research extends and develops the notion that alterations in the prenatal androgen that leave no external indicators may produce life-long alterations in development and adult behavior. ..
  55. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 2001
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  56. SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
  57. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
  58. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2001
    ..abstract_text> ..
  59. New Paradigms of P450-mediated Steroids Metabolism
    Alan Conley; Fiscal Year: 2006
    ..abstract_text> ..
  60. Towards renal regeneration
    Melissa Little; Fiscal Year: 2003
    ..Human ES cell work will be performed using ES01, 02, 03, 04, 05 & 06 listed on the NIH ES cell line registry. ..
  61. Towards renal regeneration
    Melissa Little; Fiscal Year: 2004
    ..Human ES cell work will be performed using ES01, 02, 03, 04, 05 & 06 listed on the NIH ES cell line registry. ..
  62. Posttranslational Regulation of eNOS by Estrogen in the Vagina and Clitoris
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time it may advance treatments for multiple disease states associated with endothelial dysfunction and alterations in hormonal milieu. [unreadable] [unreadable] [unreadable]..