Genomes and Genes
Summary: The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
Publications269 found, 100 shown here
- Human papillomavirus is a necessary cause of invasive cervical cancer worldwideJ M Walboomers
Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
J Pathol 189:12-9. 1999..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
- Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysisSilvia de Sanjose
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
Lancet Infect Dis 7:453-9. 2007..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
- Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virusNicolas Nagot
Centre Muraz, Bobo Dioulasso, Burkina Faso
N Engl J Med 356:790-9. 2007..Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility...
- Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan AfricaCraig R Cohen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94117, USA
AIDS 24:2069-74. 2010..To determine whether healthy, young women in sub-Saharan Africa have a more activated immune milieu in the genital tract (i.e. activated CD4 T cells) than a similar population in the United States...
- Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infectionPamela P Gumbi
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
J Virol 82:8529-36. 2008..In addition, we further show that inflammatory cytokines are associated with increased levels of HIV-specific CD8 effector cells at the genital mucosa but that these were not able to control genital HIV shedding...
- Highly effective detection of human papillomavirus 16 and 18 DNA by a testing algorithm combining broad-spectrum and type-specific PCRLeen Jan van Doorn
DDL Diagnostic Laboratory, Fonteijnenburghlaan 5, 2275 CX, Voorburg, The Netherlands
J Clin Microbiol 44:3292-8. 2006..This combination of assays is more accurate than either method alone, and the novel algorithm offers a highly accurate and effective method for the analysis of HPV infections...
- Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infectionRichard M Novak
University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
Clin Vaccine Immunol 14:1102-7. 2007..However, the increased RANTES levels in a higher-risk subset of high-risk women were reduced after BV treatment...
- Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South KoreaHai Rim Shin
Research Institute, National Cancer Center, Goyang si, Gyeonggi Do, Republic of Korea
J Infect Dis 190:468-76. 2004..Little is known about the prevalence of human papillomavirus (HPV) infection in young adults in Asia...
- A self-sampling method to obtain large volumes of undiluted cervicovaginal secretionsElizabeth R Boskey
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
Sex Transm Dis 30:107-9. 2003..It should prove suitable for a wide range of assays, including those involving sexually transmitted diseases, microbicides, vaginal physiology, immunology, and pathophysiology...
- PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trialMarla J Keller
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Infect Dis 193:27-35. 2006..5%) is sufficiently bioavailable and retains substantial antiviral activity after intravaginal application. This strategy provides a mechanism for testing the efficacy of a microbicide before embarking on large-scale clinical trials...
- Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zoneJeffrey Pudney
Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Biol Reprod 73:1253-63. 2005....
- Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tractKei Kawana
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Infect Immun 76:3011-8. 2008..trachomatis infection. Basal deficiency in CD1d-mediated immune responsiveness may result in susceptibility to sexually transmitted agents. Decreased CD1d-mediated signaling may help C. trachomatis evade detection by innate immune cells...
- Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysisG M Clifford
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Lancet 366:991-8. 2005..We aimed to compare HPV-type distribution in representative samples of women from different world regions...
- T-lymphocyte profile and total and virus-specific immunoglobulin concentrations in the cervix of HIV-1-infected womenAlison J Quayle
Department of Immunology, Microbiology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
J Acquir Immune Defic Syndr 44:292-8. 2007..The mucosal lymphocyte population is the largest in the body, and the gastrointestinal compartment has been well characterized in HIV infection. Much less is known about the effects of HIV on the genital tract...
- Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy womenM Prakash
Department of Immunology, Imperial College of Science Technology and Medicine (ICSTM) at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
J Reprod Immunol 52:101-11. 2001..Thus, the preferential transmission of macrophage tropic strains of HIV-1 following sexual contact cannot be explained solely on the expression of chemokine co-receptors by T lymphocyte subsets...
- Human papillomavirus E6/E7 mRNA expression in women younger than 30 years of ageT Molden
Institute of Pathology, National University Hospital, 0027 Oslo, Norway
Gynecol Oncol 100:95-100. 2006..It is not clear, however, to what extent the E6/E7 transcripts are being expressed. This may be of prognostic importance. In this study, we have determined the prevalence of HPV DNA and mRNA in 283 women younger than 30 years of age...
- Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tractAlfred Bere
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
Immunology 130:23-33. 2010..We conclude that cervical Gag-specific T-cell responses in expanded lines are most easily detectable in women who have corresponding high-magnitude Gag-specific T-cell responses in blood...
- Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than virusesSamuel K Lai
Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
Proc Natl Acad Sci U S A 107:598-603. 2010....
- Prevalence, distribution and correlates of endocervical human papillomavirus types in Brazilian womenS A Lippman
Population Council, New York, NY, USA
Int J STD AIDS 21:105-9. 2010..Additional studies mapping the distribution of HPV types worldwide are necessary to prepare for vaccination programmes and direct future vaccine development...
- A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2Christophe Vanpouille
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 201:635-43. 2010..However, both antiviral activities of acyclovir are dependent on phosphorylation by the nucleoside kinase activity of coinfecting human herpesviruses...
- Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytesM Nees
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
J Virol 75:4283-96. 2001..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
- Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infectionL Falk
Department of Dermatology and Venereology, University Hospital, Orebro, SE 701 85 Orebro, Sweden
Sex Transm Infect 81:73-8. 2005....
- Human papillomavirus testing on self-sampled cervicovaginal brushes: an effective alternative to protect nonresponders in cervical screening programsAagje G Bais
Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands
Int J Cancer 120:1505-10. 2007..euro 7,599). Offering self-sampling for hrHPV testing in nonresponders is an attractive adjunct to effectively increase population coverage of screening without the adverse effect of markedly increased costs per detected CIN2+ lesion...
- Multicenter evaluation of the BDProbeTec ET System for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine specimens, female endocervical swabs, and male urethral swabsB Van Der Pol
Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Clin Microbiol 39:1008-16. 2001....
- DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cellsT B Geijtenbeek
Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
Cell 100:587-97. 2000..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
- The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workersDianne Marais
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
Virus Res 121:220-2. 2006..5 95% CI 1.0-11.8). We conclude that the use of nonoxynol-9 did not prevent genital HPV infection and could increase the virus' ability to infect or persist...
- Assessment of MagNA pure LC extraction system for detection of human papillomavirus (HPV) DNA in PreservCyt samples by the Roche AMPLICOR and LINEAR ARRAY HPV testsMatthew P Stevens
Department of Microbiology, The Royal Women s Hospital, and Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
J Clin Microbiol 44:2428-33. 2006....
- Quantitative ex vivo analysis of functional virus-specific CD8 T lymphocytes in the blood and genital tract of HIV-infected womenRupert Kaul
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
AIDS 17:1139-44. 2003..The frequency of functional virus-specific CD3+/CD8+ T cells is similar in the genital tract and blood of HIV-1-infected women. The role of genital tract CD8 cell responses in HIV-1 control warrants further investigation...
- Improved amplification of genital human papillomavirusesP E Gravitt
Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA
J Clin Microbiol 38:357-61. 2000..This new primer system will be useful in assessing the natural history of HPV infections, particularly when the analysis requires HPV typing...
- Joint effects of different human papillomaviruses and Chlamydia trachomatis infections on risk of squamous cell carcinoma of the cervix uteriT Luostarinen
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Box 169, FIN 00171 Helsinki, Finland
Eur J Cancer 40:1058-65. 2004..Possible explanations for the observed antagonism include misclassification, selection bias or a true biological phenomenon with HPV6/11 and C. trachomatis exposures antagonizing the carcinogenic effects of HPV16...
- Cervicovaginal HCG and cervical length for prediction of preterm delivery in asymptomatic women at high risk for preterm deliveryKaliprasad Adhikari
Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research PGIMER, Sector 12, Chandigarh, 160012, India
Arch Gynecol Obstet 280:565-72. 2009..To predict the risk of preterm birth (<37 weeks) or early preterm birth (<34 weeks) by cervicovaginal HCG and cervical length measured between 24-28 weeks of gestation in asymptomatic women at high risk for preterm birth...
- The impact of syndromic treatment of sexually transmitted diseases on genital shedding of HIV-1Dawit Wolday
Ethio-Netherlands AIDS Research Project (ENARP, the Department of Gynaecology and Obstetrics, Black-Lion Teaching Hospital, Addis Ababa, Ethiopia
AIDS 18:781-5. 2004....
- Gestational age at cervical length measurement and incidence of preterm birthVincenzo Berghella
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, 834 Chestnut Street, Philadelphia, PA 19107, USA
Obstet Gynecol 110:311-7. 2007..To estimate the risk of spontaneous preterm birth based on transvaginal ultrasound cervical length and gestational age at which cervical length was measured...
- MRI of endocervicosis: an unusual cause of clustered periurethral cystic masses involving the bladderMatthew R Eskridge
Department of Urology, Medical University of South Carolina, Charleston, SC 29425, USA
AJR Am J Roentgenol 188:W147-9. 2007
- Human papillomavirus DNA detection in women with primary abnormal cytology of the cervix: prevalence and distribution of HPV genotypesE Beerens
Department of Pathology, Ghent University Hospital, Belgium
Cytopathology 16:199-205. 2005..8%). In the HSIL group the most common HPV types were 16, 52, 51 and 31; type 18 was rarely present. CONCLUSION: The role of types 31, 51 and 52 should be considered in future studies on vaccine development...
- HIV transmission: closing all the doorsCarl W Davis
Dept. of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, Philadelphia, PA 19104, USA
J Exp Med 199:1037-40. 2004
- Incidence, prevalence, and clearance of type-specific human papillomavirus infections: The Young Women's Health StudyAnna R Giuliano
Arizona Cancer Center, Tucson 85724 5024, USA
J Infect Dis 186:462-9. 2002..39; 95% confidence interval, 1.20-4.76). The median time to clearance of infection was significantly longer for oncogenic strains (9.8 months) than for nononcogenic strains (4.3 months)...
- Is sonographic assessment of cervical length better than digital examination in screening for preterm delivery in a low-risk population?Ratko Matijevic
Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Sveti Duh Hospital, Zagreb, Croatia
Acta Obstet Gynecol Scand 85:1342-7. 2006....
- Submucosal endocervicosis of the bladder: an ectopic, glandular structure of Müllerian originStefan Preusser
Department of Urology, St Gallen Cantonal Hospital, St Gallen, Switzerland
Scand J Urol Nephrol 42:88-90. 2008..Transurethral biopsy of the tumor confirmed the diagnosis of endocervicosis. Complete transurethral resection was rejected due to the absence of symptoms and the benign condition of the lesion...
- Recruitment of CD4 T lymphocytes and macrophages into the cervical epithelium of women after coitusManyu Prakash
Department of Immunology, Imperial College of Science, Technology, and Medicine at Chelsea and Westminster Hospital, United Kingdom
Am J Obstet Gynecol 188:376-81. 2003....
- Accuracy of Papanicolaou test among HIV-infected womenJean R Anderson
Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Clin Infect Dis 42:562-8. 2006..We examined the accuracy of the Papanicolaou (Pap) test among women with and women at high risk for human immunodeficiency virus (HIV) infection...
- Charts for cervical length in singleton pregnancyI M Hoesli
Department of Obstetrics and Gynecology, University Women s Hospital Basel, Basel, Switzerland
Int J Gynaecol Obstet 82:161-5. 2003..To construct charts for cervical length in a low risk population measured by transvaginal ultrasonography...
- Comparison of human papillomavirus DNA tests, liquid-based cytology and conventional cytology for the early detection of cervix uteri cancerVania R Girianelli
Brazilian National Cancer Institute, , Rio de Janeiro, RJ, Brazil
Eur J Cancer Prev 15:504-10. 2006..professional and self-collected) and liquid-based cytology with conventional cytology in the detection of cervix uteri cancer and its precursor lesions...
- Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive womenHenry Kitchener
Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
Int J Cancer 121:2484-91. 2007..Cytology appears to be sufficient for cervical surveillance, with HPV testing being less specific with poor positive predictive value. There appears to be no additional benefit from routine colposcopy...
- Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancerK L Wallin
Laboratory of Tumor Virus Epidemiology, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
N Engl J Med 341:1633-8. 1999..Infection with the human papillomavirus (HPV) has been established as a cause of cervical cancer, but the association between a positive test for HPV DNA and the risk of the subsequent development of invasive cervical cancer is unknown...
- HIV type 1 infection in women: increased transcription of HIV type 1 in ectocervical tissue explantsSusana N Asin
Veterans Affairs Medical Center, 215 N Main Street, White River Junction, VT 05009, USA
J Infect Dis 200:965-72. 2009..Mucosal surfaces of the female reproductive tract are the main routes of heterosexual transmission of human immunodeficiency virus type 1 (HIV-1), but the contribution of each of the reproductive sites to mucosal transmission is unknown...
- Cervical length at 16-22 weeks' gestation and risk for preterm deliveryJ U Hibbard
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Pritzker School of Medicine, Chicago, Illinois 60637, USA
Obstet Gynecol 96:972-8. 2000..To determine whether cervical length, as measured by transvaginal sonogram in asymptomatic gravidas at 16-22 weeks, is associated with risk of spontaneous preterm delivery...
- Cervical length at mid-pregnancy and the risk of primary cesarean deliveryGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
N Engl J Med 358:1346-53. 2008..We hypothesized that a long cervix in mid-pregnancy would be associated with an increased risk of cesarean delivery during labor at term...
- Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteinsS A Follows
Department of Microbiology, Section of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Infect Immun 77:3602-10. 2009..Securing an intracellular niche through the inhibition of apoptosis may be an important mechanism utilized by N. gonorrhoeae for microbial survival and immune evasion in cervical epithelial cells...
- Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarkerRalf Hilfrich
Cytoimmun Diagnostics, Pirmasens, Germany
Anal Quant Cytol Histol 30:78-82. 2008..To proof the prognostic relevance of HPV L1 capsid protein detection on colposcopically-guided punch biopsies in combination with p16...
- Altering mucus rheology to "solidify" human mucus at the nanoscaleSamuel K Lai
Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland, USA
PLoS ONE 4:e4294. 2009..These findings provide important insight into the nanoscale structural and barrier properties of mucus, and how the penetration of foreign particles across mucus might be inhibited...
- A distinct cellular profile is seen in the human endocervix during Chlamydia trachomatis infectionMercedes Ficarra
Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
Am J Reprod Immunol 60:415-25. 2008..The endocervix is a major target of Chlamydia trachomatis infection, but little is known about the immune repertoire in this tissue, or its response to these common bacteria...
- Suppressive acyclovir therapy reduces HIV cervicovaginal shedding in HIV- and HSV-2-infected women, Chiang Rai, ThailandEileen F Dunne
National Center for HIV, Viral Hepatitis and STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Acquir Immune Defic Syndr 49:77-83. 2008..Herpes simplex virus type 2 infection is important in the HIV epidemic and may contribute to increased HIV transmission. We evaluated the effect of suppressive acyclovir therapy on cervicovaginal HIV-1 shedding...
- Second-trimester cervical ultrasound: associations with increased risk for recurrent early spontaneous deliveryW W Andrews
Center for Research in Women s Health, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233 7333, USA
Obstet Gynecol 95:222-6. 2000..To determine whether short cervical length or internal os funneling before 20 weeks' gestation predicts early preterm birth or pregnancy loss in women with at least one prior spontaneous early preterm birth...
- Treatment of cervicitis is associated with decreased cervical shedding of HIV-1R S McClelland
Department of Medicine, University of Washington, Seattle 98104, USA
AIDS 15:105-10. 2001..Treatment of sexually transmitted diseases may be an important means of decreasing the infectivity of HIV-1 seropositive women by reducing exposure to HIV-1 in genital secretions...
- Coming of age: reconstruction of heterosexual HIV-1 transmission in human ex vivo organ culture systemsP J Southern
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, USA
Mucosal Immunol 4:383-96. 2011..Expanding from the current foundations, we believe that human organ cultures will become increasingly prominent in experimental studies of HIV-1 transmission and continuing efforts to prevent HIV-1 infection at human mucosal surfaces...
- HPV31 and HPV33 incidence in cervical samples from women in Recife, BrazilM F P T Baldez da Silva
Departamento de Genetica, Laboratório de Estudos Moleculares e Terapia Experimental, Universidade Federal de Pernambuco, Recife, PE, Brasil
Genet Mol Res 8:1437-43. 2009..There was a strong prevalence of HPV16 and a high incidence of HPV types 31 and 33. These data foster the discussion about the need to evaluate viral prevalence in each geographic region in order to develop targeted vaccine programs...
- Psychological burden of testing positive for high-risk human papillomavirus on women with atypical cervical cytology: a prospective studyTracy T C Kwan
Department of Obstetrics and Gynaecology, The University of Hong Kong, China
Acta Obstet Gynecol Scand 90:445-51. 2011..To assess the psychological burden of testing positive for high-risk human papillomavirus (HPV) on Chinese women with atypical squamous cells of undetermined significance (ASCUS)...
- Prevalence and risk factors of cervicovaginal HIV shedding among HIV-1 and HIV-2 infected women in Dakar, SenegalK Seck
, IHS, Dakar, , , France
Sex Transm Infect 77:190-3. 2001..2 (0.5-2.9)). CONCLUSION: Advanced disease stage and immunosuppression are the major risk determinants for shedding of both HIV-1 and HIV-2. Basic vaginal pH is also a risk determinant for HIV-1 shedding...
- Computerized planimetry versus clinical assessment for the measurement of cervical ectopiaC S Morrison
Clinical Research Division, Family Health International, Research Triangle Park, North Carolina 27709, USA
Am J Obstet Gynecol 184:1170-6. 2001..Clinical assessment of cervical ectopia may be used when computer planimetry is not available...
- Immunohistochemical phenotype of the urinary bladder endocervicosis: comparison with normal endocervix and well-differentiated mucinous adenocarcinoma of uterine cervixHiroyuki Hao
Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
Pathol Int 60:528-32. 2010..Furthermore, diffuse distribution of estrogen and progesterone receptors, lack of human gastric mucin and low proliferative activity were distinct features for endocervicosis compared to well-differentiated mucinous adenocarcinoma...
- Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected womenAlfred Bere
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
J Immunol Methods 354:68-79. 2010..Irrespective of the expansion method used, the T cell memory profile was altered following expansion...
- A comparison of four screening methods for cervical neoplasiaSufang Wu
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei 430030, China
Int J Gynaecol Obstet 91:189-93. 2005..The DNA hybridization assay is the best choice in primary screening, if available. Screening should begin at the age of 20 years...
- Outcome of women with index smear showing mild dyskaryosis: effects of age and evidence of HPV infectionC M Winn
Cellular Pathology Department, Royal Cornwall Hospital, Truro, Cornwall, UK
Cytopathology 16:281-9. 2005..Colposcopy could therefore be avoided in this group. This study also assessed whether age or human papillomavirus (HPV) status affected this outcome and the impact of non-attenders on the reliability of surveillance...
- High levels of HPV-16 DNA are associated with high-grade cervical lesions in women at risk or infected with HIVJulie Fontaine
, , , , Canada
AIDS 19:785-94. 2005..007). CONCLUSION: Higher HPV-16 DNA loads are associated with cervical lesions detected by either histology or cytology. No additional information is gained by measuring integrated or episomal over total HPV-16 DNA loads...
- Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa RicaSophia S Wang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 13:1355-60. 2004..Whereas our data support the diagnostic potential for p16INK4a, further prospective studies with detailed follow-up determining the prognostic capacity of this marker are needed...
- Reflex high-risk human papilloma virus DNA test is useful in the triage of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesionHoward Her Juing Wu
Department of Pathology, Ball Memorial Hospital, Muncie, Indiana 47303, USA
Diagn Cytopathol 34:707-10. 2006....
- Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. Study design and baseline data of the LAMS studyK Syrjanen
Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland
Anticancer Res 25:3469-80. 2005....
- Predicting CIN2+ when detecting HPV mRNA and DNA by PreTect HPV-proofer and consensus PCR: A 2-year follow-up of women with ASCUS or LSIL Pap smearTor Molden
Institute of Pathology, The National University Hospital, 0027 Oslo, Norway
Int J Cancer 114:973-6. 2005..With equal sensitivity and higher specificity than consensus PCR, the PreTect HPV-Proofer might offer an improvement for the triage of women with ASCUS or LSIL Pap smear...
- Human papillomavirus capsid antibody response to natural infection and risk of subsequent HPV infection in HIV-positive and HIV-negative womenRaphael P Viscidi
Johns Hopkins Hospital, Blalock Room 1105, 600 North Wolfe Street, Baltimore, MD 21287, USA
Cancer Epidemiol Biomarkers Prev 14:283-8. 2005..0-2.0). The lack of a protective immune effect from natural infection is most likely due to the low level of antibody elicited by natural HPV infection and/or the potential for reactivation of HPV, especially in HIV-positive women...
- Recovery of DNA for the detection and genotyping of human papillomavirus from clinical cervical specimens stored for up to 2 years in a universal collection medium with denaturing reagentElisabete A Campos
Department of Obstetrics and Gynecology, Universidade Estadual de Campinas UNICAMP, Sao Paulo, Brazil
J Virol Methods 147:333-7. 2008..The DNA extracted from the denatured specimen was recovered in 57/60 (95%) of the samples. HPV DNA was detected in 56/57 (98%) of the recovered samples. Twenty-six of the 56 samples recovered (48%) were genotyped successfully...
- Test performance comparison of inform HPV and hybrid capture 2 high-risk HPV DNA tests using the SurePath liquid-based Pap test as the collection methodSharon Davis-Devine
Department of Cytopathology, Carle Clinic, University of Illinois, Urbana, IL 61801, USA
Am J Clin Pathol 124:24-30. 2005..When SurePath is used for collection, Inform HPV lacks sufficient sensitivity to detect HSIL reliably...
- Genital human papillomavirus testing by in situ hybridization in liquid atypical cytologic materials and follow-up biopsiesC Bewtra
Department of Pathology, Creighton University Medical Center, Omaha, Nebraska 68131, USA
Acta Cytol 49:127-31. 2005..CONCLUSION: There is a small but significant (14%) false negative rate with HPV testing by the Ventana ISH method. Clinically suspicious cases should be followed even if an HPV test is negative...
- [Advances in cervical pathology: the perspective of the European colposcopists]J-C Boulanger
, CHU d'Amiens, 126, rue Camille-Desmoulins, 80054 Amiens cedex 01, France
Gynecol Obstet Fertil 33:50-4. 2005
- HPV prevalence and concordance in the cervix and oral cavity of pregnant womenE M Smith
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Infect Dis Obstet Gynecol 12:45-56. 2004..This investigation examined human papillomavirus (HPV) in pregnant women in order to characterize viral prevalence, types and concordance between infection in the cervix and in the oral cavity...
- Detection of human papillomavirus infection of the cervix in very elderly women using PCRKaiyo Takubo
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Clin Cancer Res 11:2919-23. 2005....
- [Assesment of real optoelectronic method in the detection of cervical intraepithelial neoplasia]Dominik Pruski
Klinika Onkologii Ginekologicznej, Katedra Ginekologii, Połoznictwa i Onkologii Ginekologicznej UM im K Marcinkowskiego w Poznaniu
Ginekol Pol 79:342-6. 2008..Biophysics is becoming an important factor in prevention of cervical cancer. One of the most promising concepts of biophysical program for the prevention of cervical cancer is the optoelectronic method--Truscreen...
- [Association between high risk HPV viral load, p16ink4a expression and intra-epithelial cervical lesions]Jose Eleutério Junior
Departamento de Tocoginecologia, Universidade Estadual de Campinas, Campinas, SP
Rev Assoc Med Bras 53:530-4. 2007..To determine the (HR-HPV) high risk HPV viral load in squamous intra-epithelial lesions and association with p16INK4a expression...
- Prospective evaluation of the Hybrid Capture 2 and AMPLICOR human papillomavirus (HPV) tests for detection of 13 high-risk HPV genotypes in atypical squamous cells of uncertain significancePhilippe Halfon
Alphabio Laboratory, 23 Rue de Friedland, 13006 Marseille, France
J Clin Microbiol 45:313-6. 2007..The NPV was 97.4% for the AMPLICOR assay and might be compromised if HPV types 26, 53, and 66 were considered oncogenic. The accuracy of these two assays is good and is compatible with routine clinical use in the triage of ASCUS cases...
- Agreement between the AMPLICOR Human Papillomavirus Test and the Hybrid Capture 2 assay in detection of high-risk human papillomavirus and diagnosis of biopsy-confirmed high-grade cervical diseaseFrancesca Carozzi
Centro per lo Studio e la Prevenzione Oncologica, Unità Operativa Citologia Analitica e Molecolare, Via Cosimo il Vecchio 2, 50127 Firenze, Italy
J Clin Microbiol 45:364-9. 2007..7% of cases, while 21% of cases were negative. In conclusion, AMP provides a viable alternative to HC2, with good agreement for samples with high-grade cytology and similar sensitivity in detecting CIN2+ lesions...
- Human Papillomavirus infections in Cuban women with cervical intraepithelial neoplasiaYudira Soto
Virology Department, , Havana City, Cuba
Sex Transm Dis 34:974-6. 2007
- Human papillomavirus (HPV) types 101 and 103 isolated from cervicovaginal cells lack an E6 open reading frame (ORF) and are related to gamma-papillomavirusesZigui Chen
Department of Microbiology and Immunology, Albert Einstein Cancer Center, Albert Einstein College of Medicine of Yeshiva University, NY 10461, USA
Virology 360:447-53. 2007..Moreover, this is the first report of HPVs lacking an E6 ORF and phylogenetic evidence suggests this occurred subsequent to their emergence from the gamma-/pi-PVs...
- Pap cytopathology and the presence of high-risk human papillomavirus in SurePath liquid preservative and Digene cervical sampler specimensJulius Kapala
Gamma Dynacare Medical Laboratories, Brampton, Ont, Canada
J Virol Methods 142:223-5. 2007..A majority of women had normal cervical readings although 15.8% were HPV-positive. Half of the patients with a reading of atypical squamous cells of undetermined significance (ASCUS) (n=16) were HPV-positive...
- Comparison of the AMPLICOR human papillomavirus test and the hybrid capture 2 assay for detection of high-risk human papillomavirus in women with abnormal PAP smearM A De Francesco
Institute of Microbiology and Virology, Spedali Civili, University of Brescia, Brescia, Italy
J Virol Methods 147:10-7. 2008..In conclusion, the study shows that the AMPLICOR assay is more sensitive than HC2, which makes it a valid alternative for routine clinical use...
- A comparison of cervical and vaginal human papillomavirusPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
Sex Transm Dis 34:849-55. 2007..Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells...
- Management of minor cervical cytological abnormalities: a systematic review and a meta-analysis of the literatureM Kyrgiou
Department of Obstetrics and Gynaecology, Victoria Hospital, Blackpool FY3 8NR, UK
Cancer Treat Rev 33:514-20. 2007..However, protracted attendance for cytological follow-up decreases with time and might put some women at risk of developing invasive disease. The aim of this review was to assess management options for women with minor cervical disease...
- [Use of high-risk human papillomavirus DNA testing to deal with atypical squamous cells undetermined significance and low squamous intraepithelial lesion]Yan-Li Guo
Department of Gynaecology and Obstetrics, Peking University Third Hospital, Beijing 100083, China
Beijing Da Xue Xue Bao 38:480-2. 2006..99 and > or = 10 was 1.6% and 10.7%, respectively. CONCLUSION: High-risk HPV DNA test were helpful to improve the detection rates of CIN 2, 3 or cervical cancer in patients with ASC-US...
- Detection of human papillomavirus in intraepithelial lesions and carcinoma of the cervix uteri in southern Thai womenKobkul Tungsinmunkong
Department of Pathology, Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
Asian Pac J Cancer Prev 7:427-30. 2006To evaluate the prevalence of high-risk type human papillomavirus (HR-HPV) in preneoplastic lesions and invasive squamous cell carcinoma (SCC) of the cervix uteri in southern Thai women.
- Human papillomavirus (HPV) in atypical squamous cervical cytology: the Invader HPV test as a new screening assayAnna K Wong
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
J Clin Microbiol 46:869-75. 2008....
- Aided visual inspection with acetic acid (VIA) and HPV detection as optional screening tools for cervical cancer and its precursor lesionsJ F Bragança
Obstetrics and Gynecology Department, Universidade Estadual de Campinas State University, Campinas, Brazil
Clin Exp Obstet Gynecol 32:225-9. 2005..To assess the contribution of visual inspection with acetic acid (VIA) and Hybrid Capture II (HCII) as adjunct methods to the Pap test in detecting cervical neoplasia...
- Prevalence of human papilloma virus infection of the uterine cervix in women with abnormal cervical cytologyE Gonzalez-Bosquet
Department of Obstetrics and Gynecology, , Esplugues, Barcelona, Spain
Eur J Gynaecol Oncol 27:135-8. 2006..5%) for the detection of HSIL by biopsy, although the specificity and positive predictive value were low, 51.5% and 52.1%, respectively. CONCLUSION: Patients with cytological HSIL have a high prevalence of HPV infection...
- [Application research on the flow-through hybridization and gene chip in human papillomavirus detection]Ping-ping Tao
Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing 100029, China
Zhonghua Fu Chan Ke Za Zhi 41:43-7. 2006..It provides useful information on viral genotype and is more suitable for clinical use. The 6 most common genotypes in abnormal cytological group are 16, 18, 52, 58, 33, 31...
- Differential viral loads of human papillomavirus 16 and 58 infections in the spectrum of cervical carcinogenesisH-C Lai
Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
Int J Gynecol Cancer 16:730-5. 2006..The wide variation of HPV loads among different HPV types and among squamous intraepithelial lesions and CC makes the viral load test unrealistic in differentiating different severities of cervical neoplasia...
- Linear array genotyping and hybrid capture II assay in detecting human papillomavirus genotypes in women referred for colposcopy due to abnormal Papanicolaou smearJoseph Monsonego
Institut Alfred Fournier, 25 Boulevard St Jacques, 75014 Paris, France
Int J STD AIDS 19:385-92. 2008..6%) with high NPV (98.9%) in detecting CIN3+ lesions. HPV16 genotyping alone significantly improves SP and PPV of this test in management of women with abnormal cytology...
- Evaluation of high-risk human papillomavirus types PCR detection in paired urine and cervical samples of women with abnormal cytologyA Daponte
Department of Obstetrics and Gynaecology, University Hospital of Larissa, 41110 Mezourlo, Larissa, Greece
J Clin Virol 36:189-93. 2006..During the last decade, increasing efforts have focused on HPV detection in self-obtained samples, to increase the overall proportion of patients participating in cervical cancer screening procedures...
- Comparison of the Digene HC2 assay and the Roche AMPLICOR human papillomavirus (HPV) test for detection of high-risk HPV genotypes in cervical samplesMaria T Sandri
Laboratory Medicine Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
J Clin Microbiol 44:2141-6. 2006..In conclusion, this study shows that the HC2 assay and the AMPLICOR HPV test give comparable results, with both being suitable for routine use. The differences noted in some cases may suggest a different optimal clinical use...
- Are adjunctive markers useful in routine cervical cancer screening? Application of p16(INK4a) and HPV-PCR on ThinPrep samples with histological follow-upD Schledermann
Department of Pathology, Odense University Hospital, Odense, Denmark
Diagn Cytopathol 36:453-9. 2008..If p16(INK4a) had been used for triage of the ASC samples, then 18 patients (42%) could have been spared unnecessary follow-up procedures compared to six patients (21%) with the HR-HPV DNA test...
- Prediction of recurrence after treatment for high-grade cervical intraepithelial neoplasia: the role of human papillomavirus testing and age at conisationJ Verguts
Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
BJOG 113:1303-7. 2006....
- Detection of human papillomavirus genotypes 16/18/45 by hybrid capture hybridisation genotyping probe in clinical specimens: the first reportSnjezana Zidovec Lepej
J Clin Virol 40:171-2. 2007
- Abnormal pap smears in adolescentsJanice Bacon
Department of Obstetrics and Gynecology, University of South Carolina, Columbia, South Carolina 29203, USA
J Pediatr Adolesc Gynecol 16:157-66. 2003
- Molecular diagnosis of human papillomavirus: comparison between cervical and vaginal samplingR R Finan
Department of Obstetrics and Gynecology, St. Georges-Orthodox Hospital, Beirut, Lebanon
Infect Dis Obstet Gynecol 9:119-22. 2001..Utilization of vaginal testing for routine HPV detection, and for the long-term follow-up of persistent HPV infection, is therefore recommended...
- RidCancerPain Intervention in a Hispanic Population Along the US-Mexico BorderKRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010....
- HPV & Cervix Neoplasia in a Large, Long Term HIV + CohortHoward D Strickler; Fiscal Year: 2010....
- EFFECTS OF BENZO[A]PYRENE IN TRANSGENIC MODEL OF CERVICAELLEN RORKE; Fiscal Year: 2002..Use of our novel transgenic model provides an innovative approach for addressing these questions. ..
- PAPILLOMAVIRUS HOST INTERACTIONNeil Christensen; Fiscal Year: 2007..abstract_text> ..
- Duet cervical barrier device for maximizing protective efficacy of microbicidesRichard Cone; Fiscal Year: 2007..Duet" covers the cervix for maximum protection of this susceptible site for infections, and delivers microbicide gel to protect both the cervix and vagina. The reusable Duet will be low in cost and useful for low-resource areas. ..
- HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATIONMark Dewhirst; Fiscal Year: 2009..The results of this work may lead to targeting the HRHV axis as a unique tumor specific method to treat virtually all forms of solid cancers. ..
- HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATIONMark Wesley Dewhirst; Fiscal Year: 2010..The results of this work may lead to targeting the HRHV axis as a unique tumor specific method to treat virtually all forms of solid cancers. ..
- Hormonal Regulation of the Cervix During PregnancyORRIN SHERWOOD; Fiscal Year: 2006..Treatment with RU 486 alone and in combination with exogenous relaxin will be done at term with relaxin-deficient rats. ..
- PREGNANCY OUTCOME AFTER TREATMENT OF CERVICAL DYSPLASIALynn Sadler; Fiscal Year: 2001..Outcome of the first >/= 20 week pregnancy following diagnosis will be compared for 535 treated women and 535 women not requiring treatment, using multiple logistic and linear regression models to control for confounding. ..
- Female Reproductive Organs and Their Innervation.RAYMOND PAPKA; Fiscal Year: 2006..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..
- PEROXISOME PROLIFERATOR INDUCED HEPATOCARCINOGENESISSambasiva Rao; Fiscal Year: 2004..abstract_text> ..
- Molecular epidemiology of cervical adenocarcinomaHans Olov Adami; Fiscal Year: 2007..of this project is to improve the biologic understanding of adenocarcinoma and adenosquamous cancer of the cervix uteri (in the following referred to as adenocarcinoma) through investigation of its viral etiology, and genes ..
- Enhanced Single-Visit Cervical Cancer Screening ProgramAlberto Manetta; Fiscal Year: 2006..The incremental net cost associated with an incremental improvement in outcomes in terms of quality-adjusted life years (QALYs) will be measured. ..
- Enhanced Single-Visit Cervical Cancer Screening ProgramHoda Anton Culver; Fiscal Year: 2007..The incremental net cost associated with an incremental improvement in outcomes in terms of quality-adjusted life years (QALYs) will be measured. ..