cervix uteri

Summary

Summary: The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.

Top Publications

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  2. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
  3. pmc Improved amplification of genital human papillomaviruses
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA
    J Clin Microbiol 38:357-61. 2000
  4. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
  5. ncbi Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
  6. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
  7. ncbi The natural history of cervical HPV infection: unresolved issues
    Ciaran B J Woodman
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Cancer 7:11-22. 2007
  8. ncbi Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer
    E L Franco
    Department of Oncology, McGill University, Montreal, QC, Canada H2W 1S6
    J Infect Dis 180:1415-23. 1999
  9. ncbi Patterns of known and novel small RNAs in human cervical cancer
    Weng Onn Lui
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Cancer Res 67:6031-43. 2007
  10. pmc In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide
    Lisa C Rohan
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9310. 2010

Detail Information

Publications366 found, 100 shown here

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  2. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
    ..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
  3. pmc Improved amplification of genital human papillomaviruses
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA
    J Clin Microbiol 38:357-61. 2000
    ..This new primer system will be useful in assessing the natural history of HPV infections, particularly when the analysis requires HPV typing...
  4. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
    ....
  5. ncbi Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
    ..These psychosocial aspects and the need for more information and educational programmes about HPV are also discussed in this article...
  6. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  7. ncbi The natural history of cervical HPV infection: unresolved issues
    Ciaran B J Woodman
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Cancer 7:11-22. 2007
    ..We discuss areas of uncertainty, and their possible effect on disease prevention strategies...
  8. ncbi Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer
    E L Franco
    Department of Oncology, McGill University, Montreal, QC, Canada H2W 1S6
    J Infect Dis 180:1415-23. 1999
    ..Although a woman's age did not affect mean duration for oncogenic types (13-14 months), nononcogenic-type infections lasted longer (10. 2 months) among younger (<35 years old) than in older women (5.6 months)...
  9. ncbi Patterns of known and novel small RNAs in human cervical cancer
    Weng Onn Lui
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Cancer Res 67:6031-43. 2007
    ..In addition to the known miRNAs, we found a number of novel miRNAs and an additional set of small RNAs that do not meet miRNA criteria...
  10. pmc In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide
    Lisa C Rohan
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9310. 2010
    ..To validate our findings with on-going clinical trial results, we evaluated topical tenofovir gel for safety and efficacy. We also modeled systemic application of tenofovir for efficacy...
  11. ncbi Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term
    Inass Osman
    University of Glasgow, Department of Obstetrics and Gynaecology, 3rd Floor, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, UK
    Mol Hum Reprod 9:41-5. 2003
    ..These data lend further support to the hypothesis that labour is an inflammatory process...
  12. ncbi Progesterone and the risk of preterm birth among women with a short cervix
    Eduardo B Fonseca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    N Engl J Med 357:462-9. 2007
    ..Asymptomatic women found at midgestation to have a short cervix are at greatly increased risk for spontaneous early preterm delivery, and it is unknown whether progesterone reduces this risk in such women...
  13. pmc Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
    J Natl Cancer Inst 100:513-7. 2008
    ..These findings suggest that the medical community should emphasize persistence of cervical HPV infection, not single-time detection of HPV, in management strategies and health messages...
  14. ncbi The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission
    R N Fichorova
    Fearing Research Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Thorn 217, Boston, MA 02115, USA
    J Infect Dis 184:418-28. 2001
    ..Furthermore, this study identifies in vitro and in vivo model systems for monitoring undesirable proinflammatory effects of microbicides and other vaginal products...
  15. pmc Highly effective detection of human papillomavirus 16 and 18 DNA by a testing algorithm combining broad-spectrum and type-specific PCR
    Leen Jan van Doorn
    DDL Diagnostic Laboratory, Fonteijnenburghlaan 5, 2275 CX, Voorburg, The Netherlands
    J Clin Microbiol 44:3292-8. 2006
    ..This combination of assays is more accurate than either method alone, and the novel algorithm offers a highly accurate and effective method for the analysis of HPV infections...
  16. ncbi Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study
    C B Woodman
    Centre for Cancer Epidemiology, University of Manchester, Withington, M20 4QL, Manchester, UK
    Lancet 357:1831-6. 2001
    ..We studied the natural history of incident cervical HPV infection and its relation to the development of CIN...
  17. ncbi Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus
    Nicolas Nagot
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    N Engl J Med 356:790-9. 2007
    ..Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility...
  18. ncbi European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1
    J Jordan
    Birmingham Women s Hospital, Birmingham, UK
    Cytopathology 19:342-54. 2008
    ....
  19. pmc HIV binding, penetration, and primary infection in human cervicovaginal tissue
    Diane Maher
    Department of Microbiology, University of Minnesota Medical School, MMC 196, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 102:11504-9. 2005
    ..Collectively, these results highlight a continuum of complex interactions that occurs when natural sources of HIV infectivity are deposited onto mucosal surfaces in the female reproductive tract...
  20. ncbi Determinants of clearance of human papillomavirus infections in Colombian women with normal cytology: a population-based, 5-year follow-up study
    Monica Molano
    Department of Pathology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Am J Epidemiol 158:486-94. 2003
    ..Observed was slower clearance in parous women (RR = 0.64, 95% CI: 0.47, 0.89) and faster clearance in ever users of oral contraceptives (RR = 1.38, 95% CI: 1.07, 1.77)...
  21. ncbi Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice
    Charles P Read
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    Reproduction 134:327-40. 2007
    ....
  22. ncbi Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells
    R N Fichorova
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 60:508-14. 1999
    ....
  23. pmc Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    C A Gaydos
    Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
    J Clin Microbiol 48:3236-43. 2010
    ..trachomatis and N. gonorrhoeae dual detection with high sensitivity and specificity. The automated assay provides a useful alternative nucleic acid amplification assay for clinical laboratories and clinicians...
  24. ncbi Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers
    A Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    J Proteome Res 10:5139-49. 2011
    ..This comprehensive systems biology approach identifies mucosal serpins and cystatins as novel correlates of HIV-1-resistance. This represents the first study characterizing these factors in the female genital tract...
  25. pmc Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial
    S S Hassan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Ultrasound Obstet Gynecol 38:18-31. 2011
    ..This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix...
  26. ncbi Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells
    David J Sharkey
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Mol Hum Reprod 13:491-501. 2007
    ..Seminal factor regulation of inflammatory cytokines in the cervical epithelium is implicated in controlling the immune response to seminal antigens, and defence against infectious agents introduced at intercourse...
  27. ncbi Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion
    Yali Zhai
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cancer Res 67:10163-72. 2007
    ..Other genes with differential expression in invasive SCC versus HSIL may contribute to tumor progression or may be useful as markers for cancer diagnosis or progression risk...
  28. ncbi Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysis
    Patrick Petignat
    Senology and Gynaecologic Oncology Unit, Geneva University Hospitals, 1211 Geneva 14, Switzerland
    Gynecol Oncol 105:530-5. 2007
    ..To compare the detection rate of genital human papillomavirus (HPV) infection in self- and physician-obtained samples...
  29. ncbi Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:46-52. 2003
    ..We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer...
  30. pmc Prevalence of type-specific HPV infection by age and grade of cervical cytology: data from the ARTISTIC trial
    A Sargent
    Division of Cancer Studies and Imaging, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Br J Cancer 98:1704-9. 2008
    ..In the absence of broader cross-protection, the large majority of low-grade and many high-grade abnormalities may still occur in sexually active vaccinated women...
  31. ncbi Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia
    Marc Arbyn
    European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
    J Natl Cancer Inst 96:280-93. 2004
    ..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
  32. pmc Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, RF468, Boston, MA 02115, USA
    Infect Immun 74:5773-9. 2006
    ..These effects were dose dependent and sustained in the absence of cytotoxicity and IL-1beta release and utilized, at least in part, a signaling pathway independent from the Toll-like/IL-1 receptor adaptor protein MyD88...
  33. pmc Detection of human papillomavirus DNA in urine specimens from human immunodeficiency virus-positive women
    Joeli A Brinkman
    Department of Microbiology Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2822, USA
    J Clin Microbiol 40:3155-61. 2002
    ..Additional studies with larger sample sizes must be conducted in order to further verify these findings...
  34. ncbi A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models
    Angela Berzi
    Department of Clinical Sciences L Sacco, University of Milan, Segrate, Italy
    AIDS 26:127-37. 2012
    ..Inhibition of HIV interaction with DC-SIGN thus represents a potential therapeutic approach for viral entry inhibition at the mucosal level...
  35. ncbi Imaging of uterine cancer
    Oguz Akin
    Weill Medical College of Cornell University, New York, NY, USA
    Radiol Clin North Am 45:167-82. 2007
    ..This article reviews the applications of modern imaging modalities in the assessment of endometrial cancer and cervical cancer and their impact on treatment planning and posttreatment follow-up...
  36. ncbi The diagnostic performance of classical molecular tests used for detecting human papillomavirus
    Marina Munoz
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Bogota, Colombia marina
    J Virol Methods 185:32-8. 2012
    ..Women positive for pU1M/2R may be at higher risk of disease progression; the assay performance when combined with a Pap smear in cervical cancer screening programs should be evaluated...
  37. pmc A compact fiber-optic SHG scanning endomicroscope and its application to visualize cervical remodeling during pregnancy
    Yuying Zhang
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:12878-83. 2012
    ....
  38. ncbi IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes
    Correne A DeCarlo
    Thunder Bay Regional Research Institute, Probe Development and Biomarker Exploration, Thunder Bay, ON, Canada
    Lab Invest 90:1482-91. 2010
    ..Altogether, these findings show that IFN-κ is down-regulated in cervical keratinocytes harboring HPV, which may be a contributing factor in the progression of a cervical lesion...
  39. ncbi Prevalence and risk factors for cervical HPV infection and abnormalities in young adult women at enrolment in the multinational PATRICIA trial
    Edith Roset Bahmanyar
    GlaxoSmithKline Vaccines, Wavre, Belgium
    Gynecol Oncol 127:440-50. 2012
    ..We evaluated baseline data from the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681) on the association between behavioral risk factors and HPV infection and cervical abnormalities...
  40. ncbi Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone
    Jeffrey Pudney
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 73:1253-63. 2005
    ....
  41. ncbi Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis
    G M Clifford
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Lancet 366:991-8. 2005
    ..We aimed to compare HPV-type distribution in representative samples of women from different world regions...
  42. ncbi Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes
    Mark R Pett
    Medical Research Council Cancer Cell Unit, MRC Hutchison Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cancer Res 64:1359-68. 2004
    ..HR-HPV integration is likely to be a critical event in cervical carcinogenesis, preceding the development of chromosomal abnormalities that drive malignant progression...
  43. ncbi Analytical characterization of the APTIMA HPV Assay
    Janel Dockter
    Gen Probe Incorporated, San Diego, California 92121, USA
    J Clin Virol 45:S39-47. 2009
    ..The APTIMA HPV Assay however, detects HPV E6/E7 mRNA from 14 high-risk types of HPV: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68...
  44. pmc Temporal changes in myeloid cells in the cervix during pregnancy and parturition
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:2700-7. 2009
    ..Additionally, macrophages with diverse phenotypes (M1 and M2) are present in the cervix and are most likely involved in the postpartum repair of tissue...
  45. pmc Non-infected preterm parturition is related to increased concentrations of IL-6, IL-8 and MCP-1 in human cervix
    Susanne Abelin Törnblom
    Division for Obstetrics and Gynecology, Dept of Women and Child Health, Karolinska Institute, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
    Reprod Biol Endocrinol 3:39. 2005
    ..The aim of this study was to investigate if there are differences in the inflammatory process of preterm and term cervical ripening...
  46. pmc Use of human tissue explants to study human infectious agents
    Jean Charles Grivel
    Section of Intercellular Interactions, Program on Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 10 Centre Drive, Room 9D58, Bethesda, Maryland 20892, USA
    Nat Protoc 4:256-69. 2009
    ..Using this protocol, culture and infections can be set up in 3-6 h and be maintained for 2-3 weeks, depending on the tissue used...
  47. ncbi The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
    M S Mahendroo
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Mol Endocrinol 13:981-92. 1999
    ....
  48. ncbi Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G
    Bradley J Catalone
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biomed Pharmacother 59:430-7. 2005
    ..These results provide further insight into the activity of C31G, as well as mechanisms potentially associated with microbicide toxicity...
  49. pmc Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
    Barry R O'Keefe
    Molecular Targets Development Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:6099-104. 2009
    ..Moreover, GRFT-P is potently active in preventing infection of cervical explants by HIV-1 and has no mitogenic activity on cultured human lymphocytes...
  50. ncbi Comparison of AMPLICOR and Hybrid Capture II assays for high risk HPV detection in normal and abnormal liquid-based cytology: use of INNO-LiPA Genotyping assay to screen the discordant results
    L Z Mo
    EA3181, IFR133, Universite de Franche Comte, 25000 Besancon, France
    J Clin Virol 41:104-10. 2008
    ..6%) and specificity (100%) of AMPLICOR was similar to that of HCII Test. The AMPLICOR HPV Test is sensitive, specific, feasible and appropriate for routine HPV detection...
  51. ncbi Search for cellular partners of human papillomavirus type 16 E2 protein
    Agnieszka K Olejnik-Schmidt
    Department of Biotechnology and Food Microbiology, August Cieszkowski University of Agriculture, Wojska Polskiego Street No 48, 60 627 Poznan, Poland
    Arch Virol 153:983-90. 2008
    ..Using a yeast two-hybrid system, we have identified epithelial cellular proteins that bind to the E2 protein of HPV16...
  52. ncbi HPV genotypes in women with squamous intraepithelial lesions and normal cervixes participating in a community-based microbicide study in Pretoria, South Africa
    H M Said
    Faculty of Health Science, Department of Medical Microbiology, University of Pretoria, South Africa
    J Clin Virol 44:318-21. 2009
    ..Little is known regarding the human papillomaviruses (HPV) genotypes prevalent in women in South Africa, a country with a high incidence of cervical cancer...
  53. ncbi Molecular methods for a correct diagnosis of multiple HPV infections and clinical implications for vaccine
    Andrea Tinelli
    Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Department of Obstetrics and Gynaecology, Vito Fazzi Hospital, 73100 Lecce, Italy
    Int J Gynecol Cancer 21:545-50. 2011
    ..The aim of this study was to detect the HPV coinfections and the inner genotype in a series of 336 cervical-vaginal samples...
  54. ncbi High-risk human papillomavirus reactivation in human immunodeficiency virus-infected women: risk factors for cervical viral shedding
    Regan N Theiler
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77550 0587, USA
    Obstet Gynecol 115:1150-8. 2010
    ..To evaluate the presence of and estimate risk factors for reactivation of latent high-risk human papillomavirus (HPV) cervical infection in human immunodeficiency virus (HIV)-infected and HIV-uninfected women...
  55. ncbi Robotic uterine artery preservation and nerve-sparing radical trachelectomy with bilateral pelvic lymphadenectomy in early-stage cervical cancer
    Dae Gy Hong
    Department of Obstetrics and Gynecology, Kyungpook National University, Daegu, Korea
    Int J Gynecol Cancer 21:391-6. 2011
    ..The aim of the study was to evaluate the safety and feasibility of robotic uterine artery preservation and nerve-sparing radical trachelectomy with pelvic lymphadenectomy using the da Vinci surgical system...
  56. ncbi Fertility-preserving surgical procedures for patients with gynecologic malignancies
    Nabila Rasool
    Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Obstet Gynecol 53:804-14. 2010
    ....
  57. pmc Prevalence and risk profile of cervical Human papillomavirus infection in Zhejiang Province, southeast China: a population-based study
    Jing Ye
    Women s Reproductive Health Key Laboratory of Zhejiang Province, Women s Hospital, School of Medicine, Zhejiang University, Xueshi Rd 2, Hangzhou, PR China
    Virol J 7:66. 2010
    ..Here, we investigated the prevalence of cervical HPV infection, as well as predictors concerned, in Zhejiang Province, southeast China...
  58. ncbi Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarker
    Ralf Hilfrich
    Cytoimmun Diagnostics, Pirmasens, Germany
    Anal Quant Cytol Histol 30:78-82. 2008
    ..To proof the prognostic relevance of HPV L1 capsid protein detection on colposcopically-guided punch biopsies in combination with p16...
  59. pmc Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa
    Craig R Cohen
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94117, USA
    AIDS 24:2069-74. 2010
    ..To determine whether healthy, young women in sub-Saharan Africa have a more activated immune milieu in the genital tract (i.e. activated CD4 T cells) than a similar population in the United States...
  60. pmc The association between cervical human papillomavirus infection and HIV acquisition among women in Zimbabwe
    Sarah H Averbach
    University of California, San Francisco School of Medicine, San Francisco, California, USA
    AIDS 24:1035-42. 2010
    ..The prevalence of human papillomavirus (HPV) is higher among HIV-positive women, but the prevalence of HPV prior to HIV acquisition has not been carefully evaluated...
  61. ncbi Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias
    Richard A Watson
    Cancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, UK
    Carcinogenesis 23:1791-6. 2002
    ..In invasive squamous cell carcinomas, total cellular hDlg levels are greatly reduced. Our data suggest that loss of hDlg at sites of intercellular contact may be an important step in the development of epithelial cancers...
  62. pmc Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response
    Mark R Pett
    Medical Research Council Cancer Cell Unit, Cambridge CB2 2XZ, United Kingdom
    Proc Natl Acad Sci U S A 103:3822-7. 2006
    ..We conclude that cervical carcinogenesis requires not only HRHPV integration, but also loss of inhibitory episomes...
  63. pmc Association of HIV infection with distribution and viral load of HPV types in Kenya: a survey with 820 female sex workers
    Stanley M F Luchters
    International Centre for Reproductive Health ICRH, Ghent University, Belgium
    BMC Infect Dis 10:18. 2010
    ..Interactions between these infections pose substantial public health challenges, especially where HIV prevalence is high and HPV vaccine coverage low...
  64. ncbi Cytokine networks and the regulation of uterine function in pregnancy and parturition
    N M Orsi
    Perinatal Research Group, The YCR and Liz Dawn Pathology and Translational Sciences Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    J Neuroendocrinol 20:462-9. 2008
    ..Further insight into the complexity of cytokine networks will be required to develop novel therapeutic strategies for the treatment of cytokine imbalances in pregnancy...
  65. pmc High-risk HPV type-specific clearance rates in cervical screening
    N W J Bulkmans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Br J Cancer 96:1419-24. 2007
    ..For the other hrHPV-positive women, it seems advisable to adopt a conservative management with a long waiting period, as hrHPV clearance is markedly higher after 18 months than after 6 months and the risk for >or=CIN3 is low...
  66. pmc Cervical remodeling during pregnancy and parturition
    Brenda Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9032, USA
    Trends Endocrinol Metab 21:353-61. 2010
    ..Recent advances in our understanding of term and preterm cervical remodeling provide new directions for investigation and compel investigators to reevaluate currently accepted models...
  67. ncbi Biased amplification of human papillomavirus DNA in specimens containing multiple human papillomavirus types by PCR with consensus primers
    Seiichiro Mori
    Pathogen Genomics Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo NTT Medical Center Tokyo, Shinagawa ku, Tokyo, Japan
    Cancer Sci 102:1223-7. 2011
    ..The data indicate that PCR with consensus primers is not suitable for genotyping HPV in specimens containing multiple HPV types, and suggest that the genotyping data obtained by such a method should be carefully interpreted...
  68. ncbi Expression of toll-like receptor 4 is down-regulated during progression of cervical neoplasia
    Li Yu
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen Zhongshan University, Guangzhou, People s Republic of China
    Cancer Immunol Immunother 59:1021-8. 2010
    ..These data offer further insight regarding the association of HPV infection and TLR signaling during the carcinogenesis of cervical cancer...
  69. ncbi Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term
    Anne Young
    Department of Obstetrics and Gynaecology, Queen Elizabeth Building, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, United Kingdom
    Biol Reprod 66:445-9. 2002
    ..In fetal membranes collected at labor, IL-8 was expressed in decidual stromal cells. Infiltrating leukocytes are a major source of cytokines in uterine tissues during labor...
  70. pmc HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model
    E Saba
    Program in Physical Biology, Section of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 3:280-90. 2010
    ..These results provide new insights into the dependence of HIV-1 infection and dissemination on the activation/differentiation of cervico-vaginal lymphocytes...
  71. pmc Enhanced detection and typing of human papillomavirus (HPV) DNA in anogenital samples with PGMY primers and the Linear array HPV genotyping test
    Francois Coutlee
    Laboratoire de Virologie Moléculaire du Centre de Recherche, Departement De Microbiologie et Infectiologie, Hôpital Notre Dame du Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    J Clin Microbiol 44:1998-2006. 2006
    ..06; P = 0.57), CD4 cell counts (r = 0.06 +/- 0.06; P = 0.13), or the grade of anal disease (r = -0.11 +/- 0.06; P = 0.07). LA-HPV compared favorably with PGMY-LB but yielded higher detection rates for newer and well-known HPV types...
  72. pmc Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length
    John Owen
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249 7333, USA
    Am J Obstet Gynecol 201:375.e1-8. 2009
    ..The objective of the study was to assess cerclage to prevent recurrent preterm birth in women with short cervix...
  73. pmc Comparing first-void urine specimens, self-collected vaginal swabs, and endocervical specimens to detect Chlamydia trachomatis and Neisseria gonorrhoeae by a nucleic acid amplification test
    Mary Ann Shafer
    Division of Adolescent Medicine, Department of Pediatrics, University of California, San Francisco 94143, USA
    J Clin Microbiol 41:4395-9. 2003
    ..Self-collected vaginal swab collections are a feasible alternative to cervical specimen collections in this population, and the use of multiple types of specimens increases the positive yield markedly...
  74. pmc Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification tests
    E Van Dyck
    STD HIV Research and Intervention Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    J Clin Microbiol 39:1751-6. 2001
    ..trachomatis EIA. The accuracies of the different NAATs were quite similar. SDA was the only amplification assay with 100% specificity for detection of both N. gonorrhoeae and C. trachomatis in endocervical specimens...
  75. ncbi The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study
    Monica Molano
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Infect Dis 191:907-16. 2005
    ..4 [95% CI, 0.1-0.9]), compared with that for serovars of the intermediate group (F and G). At 4 years of follow-up, 94% of the women had cleared their infections...
  76. pmc Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 76:9868-76. 2002
    ....
  77. pmc Abundance of multiple high-risk human papillomavirus (HPV) infections found in cervical cells analyzed by use of an ultrasensitive HPV genotyping assay
    Markus Schmitt
    Department of Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg 69120, Germany
    J Clin Microbiol 48:143-9. 2010
    ..As a consequence, PCR-TS-MPG appears to be highly suited for analysis of the significance of multiple infections in the development of cervical cancer and for the study the natural history and the latency of HPV...
  78. pmc Type-specific cervico-vaginal human papillomavirus infection increases risk of HIV acquisition independent of other sexually transmitted infections
    Karen K Smith-McCune
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e10094. 2010
    ..The objective of this study was to determine whether cervico-vaginal HPV infection increases the risk of HIV acquisition in women independent of other common STIs...
  79. pmc Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection
    Richard M Novak
    University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
    Clin Vaccine Immunol 14:1102-7. 2007
    ..However, the increased RANTES levels in a higher-risk subset of high-risk women were reduced after BV treatment...
  80. ncbi Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea
    Hai Rim Shin
    Research Institute, National Cancer Center, Goyang si, Gyeonggi Do, Republic of Korea
    J Infect Dis 190:468-76. 2004
    ..Little is known about the prevalence of human papillomavirus (HPV) infection in young adults in Asia...
  81. pmc Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection
    Pamela P Gumbi
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Virol 82:8529-36. 2008
    ..In addition, we further show that inflammatory cytokines are associated with increased levels of HIV-specific CD8 effector cells at the genital mucosa but that these were not able to control genital HIV shedding...
  82. pmc Transmission of human papillomavirus in heterosexual couples
    Brenda Y Hernandez
    University of Hawaii, Manoa, HI 96813, USA
    Emerg Infect Dis 14:888-94. 2008
    ..Couples who transmitted HPV were more sexually active and used condoms less frequently. These results have implications for HPV prevention and control strategies, including the targeting of prophylactic vaccines...
  83. ncbi gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission
    Earl Stoddard
    Department of Medicine, Division of Infectious Diseases, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 179:3126-32. 2007
    ..Understanding this step in the initiation of infection will allow for the development of tools and methods for blocking HIV transmission...
  84. pmc Trichomonas vaginalis lipophosphoglycan mutants have reduced adherence and cytotoxicity to human ectocervical cells
    Felix D Bastida-Corcuera
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Eukaryot Cell 4:1951-8. 2005
    ..These combined results demonstrate that T. vaginalis adherence to host cells is LPG mediated and that an altered LPG leads to reduced adherence and cytotoxicity of this parasite...
  85. ncbi Human myometrial gene expression before and during parturition
    Jon C Havelock
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Biol Reprod 72:707-19. 2005
    ..The cellular properties of S100A9, its spatial localization, and dramatic increase in cervix and myometrium of women in labor suggest that this protein may be very important in the initiation or propagation of human labor...
  86. ncbi Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery
    Bugge Noehr
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Obstet Gynecol 114:1232-8. 2009
    ..To investigate the association between cone depth of the loop electrosurgical excision procedure (LEEP) of the cervix and subsequent risk of spontaneous preterm delivery...
  87. ncbi Incidence, duration, and determinants of cervical human papillomavirus infection in a cohort of Colombian women with normal cytological results
    Nubia Munoz
    Instituto Nacional de Cancerologia, Bogota, Colombia
    J Infect Dis 190:2077-87. 2004
    ..8 vs. 11.1 months). In this cohort of cytologically normal women, the incidence of cervical HPV infection was high, and the epidemiological profile of high-risk HPV types was different from that of low-risk types...
  88. pmc A comparison of cervical and vaginal human papillomavirus
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
    Sex Transm Dis 34:849-55. 2007
    ..Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells...
  89. pmc Human papillomavirus infection and cervical cytology in HIV-infected and HIV-uninfected Rwandan women
    Diljeet K Singh
    Division of Gynecologic Oncology, Feinberg School of Medicine, Northwestern University, and Cook County Hospital, Chicago, Illinois 60611, USA
    J Infect Dis 199:1851-61. 2009
    ..Data on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs...
  90. pmc p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis
    I Tsoumpou
    Department of Obstetrics and Gynaecology, St Mary s Hospital, CMMC University Hospitals, Manchester M13 0JH, UK
    Cancer Treat Rev 35:210-20. 2009
    ....
  91. ncbi Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts
    R Ann Word
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Semin Reprod Med 25:69-79. 2007
    ..A clear understanding of the biologic mechanisms that regulate cervical remodeling during pregnancy is needed to influence the preterm birth rate and to develop strategies to prevent preterm dilation of the cervix...
  92. pmc Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes
    M Nees
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
    J Virol 75:4283-96. 2001
    ..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
  93. ncbi A novel real-time PCR to detect Chlamydia trachomatis in first-void urine or genital swabs
    Katia Jaton
    Institute of Microbiology, University of Lausanne, Lausanne, Switzerland
    J Med Microbiol 55:1667-74. 2006
    ..trachomatis. Given its high throughput potential and low costs/laboratory technician time requirement, it may be useful for future use in large C. trachomatis screening programs...
  94. ncbi Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    Raina N Fichorova
    Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:2424-32. 2002
    ..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling...
  95. ncbi Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers
    Shehzad M Iqbal
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Infect Dis 192:728-38. 2005
    ..This is the first study to show elevated levels of beta chemokines and CD4+ T cells in the genital tracts of women who are exposed to HIV-1 and yet are uninfected...
  96. pmc Use of PGMY primers in L1 consensus PCR improves detection of human papillomavirus DNA in genital samples
    Francois Coutlee
    Laboratoire de Virologie Moleculaire, Centre de Recherche et Département de Microbiologie et Infectiologie, Hôpital Notre Dame du Centre Hospitalier de l Université de Montréal, Canada
    J Clin Microbiol 40:902-7. 2002
    ..Studies using PGMY instead of MY primers have the potential to report higher detection rates of HPV infection not only for newer HPV types but also for well-known genital types...
  97. pmc Human Papillomavirus (HPV) infection in pregnant women and mother-to-child transmission of genital HPV genotypes: a prospective study in Spain
    Xavier Castellsague
    Unit of Infections and Cancer UNIC, Cancer Epidemiology Research Program CERP, IDIBELL Institut Català d Oncologia ICO, Hospitalet de Llobregat, Barcelona, Spain
    BMC Infect Dis 9:74. 2009
    ..Studies on HPV infection in pregnant women and HPV transmission to the child have yielded inconsistent results...
  98. ncbi Aberrant methylation during cervical carcinogenesis
    A K Virmani
    Hamon Center for Therapeutic Oncology Research, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas 85930, USA
    Clin Cancer Res 7:584-9. 2001
    ....
  99. ncbi Detection of bacterial vaginosis-related organisms by real-time PCR for Lactobacilli, Gardnerella vaginalis and Mycoplasma hominis
    M Reza Zariffard
    Department of Immunology Microbiology, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
    FEMS Immunol Med Microbiol 34:277-81. 2002
    ....
  100. ncbi A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions
    Elizabeth R Boskey
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Sex Transm Dis 30:107-9. 2003
    ..A convenient method for self-sampling these secretions outside a clinical setting can facilitate such studies of reproductive health...
  101. ncbi PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 193:27-35. 2006
    ..This study was designed to determine the antiviral activity in cervicovaginal lavage (CVL) samples collected after intravaginal application of 0.5% PRO 2000 gel (Indevus)...

Research Grants76

  1. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ....
  2. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..Our results will eventually permit identification of patients at high risk for long-term toxicity, and the development of preventive and interventional strategies. 1 ..
  3. Biochemical, Biomechanical & Morphological Properties of Quantitative Ultrasound
    Barbara L McFarlin; Fiscal Year: 2010
    ..Reducing the preterm birth rate to 7% in the United States is a goal of the Healthy People 2010 initiative, and it is only by reducing the incidence of preterm birth that infant mortality in the United States can be addressed. ..
  4. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ....
  5. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ....
  6. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ....
  7. Hyperglycemia-induced DNA damage as a driver of genomic instability
    JOHN S TERMINI; Fiscal Year: 2013
    ....
  8. Innate immunity predictors of HIV: the role of contraception, pregnancy and HSV-2
    Charles Morrison; Fiscal Year: 2013
    ..This research provides a unique opportunity to elucidate and validate the complex associations between endogenous and exogenous hormones, HSV-2 and HIV-1 through analysis of underlying shared biological mechanisms. ..
  9. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ....
  10. A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    Richard F Selden; Fiscal Year: 2013
    ..Dean, and the molecular biological and microfluidic expertise of Dr. Selden, the application provides a unique collaborative opportunity to finally obtain a rapid nucleic-acid based POC diagnostic for C. trachomatis. ..
  11. CANCER AND CHANGING TRENDS IN US MORTALITY INEQUITIES: 1960-2004
    Nancy Krieger; Fiscal Year: 2010
    ....
  12. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..This Primary Care Imaging system addresses this critical need, and for the first time, brings advanced diagnostic imaging technology to the primary care office. ..
  13. Mechanism of Type I and II Caused Diabetic Bladder Dysfunction
    Firouz Daneshgari; Fiscal Year: 2013
    ..Through this collaboration, the data generated from this proposal will provide Significant comprehensive insights into the pathogenesis of DBD and on potential therapeutic targets to prevent or treat DBD effectively. ..
  14. Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response
    Steve N Caritis; Fiscal Year: 2013
    ..Finally, we will evaluate the fetal contribution to the variability in activity of these three CYP enzymes by evaluating cord/placental CYP enzymes/polymorphisms. ..
  15. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2013
    ....
  16. INITIATION OF HUMAN LABOR: PREVENTION OF PREMATURITY
    Carole R Mendelson; Fiscal Year: 2013
    ..We propose that these interrelated projects, carried out by a highly interactive research team, will achieve the long-range goals of this Program and contribute to a reduction in the incidence of preterm birth. ..
  17. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..A protective genetic microbicide delivered to the female lower genital track could dramatically slow the spread of HIV/AIDS. ..
  18. HPV &Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2013
    ....
  19. Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
    Teresa K Woodruff; Fiscal Year: 2013
    ....
  20. Estimating Ultrasound Attenuation in Human Pregnant Cervix
    BARBARA L contact MCFARLIN; Fiscal Year: 2010
    ..The long-term goal of this research program is to develop a noninvasive ultrasound technique that will detect early cervical ripening in humans and lead to scientific interventions to modify preterm birth. ..
  21. Uterine-specific genetic modification and lymphangioleiomyomatosis
    JOSE M TEIXEIRA; Fiscal Year: 2012
    ....
  22. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2013
    ..abstract_text> ..
  23. T-bet regulates CD4 memory to bacterial infection with C. trachomatis
    David Gondek; Fiscal Year: 2010
    ..We anticipate these results will influence how vaccines will be designed to protect against C. trachomatis and other sexually transmitted infections. ..
  24. Mucosal immune response of the anus in women to HPV, intercourse, smoking and OCs
    ANNA BARBARA NONE MOSCICKI; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This application plans to examine anal mucosal immune responses to human papillomavirus, tobacco use, anal intercourse and hormonal contraceptives. ..
  25. NEURAL REGULATION OF PREPARTUM CERVICAL RIPENING
    Steven M Yellon; Fiscal Year: 2013
    ....
  26. HPV Knowledge Awareness and Vaccine Acceptability among Inner City Black Males
    SHERRIE LEE WALLINGTON; Fiscal Year: 2013
    ..Moreover, this research will also build further research capacity to engage underserved adolescents in future HPV and cancer prevention interventions. ..
  27. Etiologic Role of HPV in Keratinocyte Carcinomas
    Margaret Karagas; Fiscal Year: 2009
    ..Using available data and biologic samples from a large epidemiologic study, and applying recent advances in HPV detection, we will conduct a comprehensive investigation of the role of human papilloma viruses in skin cancer occurrence. ..
  28. Genetic Analysis of Human First Trimester Trophoblast in Ongoing Pregnancies
    Michael Peter Diamond; Fiscal Year: 2013
    ..The methodologies developed in this investigation could eventually establish clinical tests that use TCS, providing information on the genetic status of the fetus before development has progressed beyond the first two months. ..
  29. Human Papillomavirus Infection in Perinatally HIV-infected Adolescents in Asia
    Annette H Sohn; Fiscal Year: 2013
    ..This study will produce the first regional-level evidence to guide HPV infection prevention and cervical intraepithelial neoplasia monitoring for perinatally HIV-infected adolescents in Asia. ..
  30. Quantification of Immune Cells in Women Using Contraception
    SHARON LYNELLE ACHILLES; Fiscal Year: 2013
    ....
  31. Primate Model of Mycoplasma genitalium
    Patricia A Totten; Fiscal Year: 2010
    ..Further establishment and characterization of this model will lead to future studies assessing the pathogenesis of M. genitalium as well as the evaluation of effective strategies for prevention and treatment. ..
  32. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2009
    ..Duet" covers the cervix for maximum protection of this susceptible site for infections, and delivers microbicide gel to protect both the cervix and vagina. The reusable Duet will be low in cost and useful for low-resource areas. ..
  33. Molecular etiology of cervicovaginal adenosis by in utero hormone exposure
    Takeshi Kurita; Fiscal Year: 2013
    ..In addition, by studying molecular etiology of HPV-negative cervical/vaginal adenocarcinoma, it may lead to early detection and discovery of a new and improved treatment for this disease. ..
  34. Effect of Lactobacillus on genital HIV-1 RNA and DNA shedding in women
    Jane E Hitti; Fiscal Year: 2010
    ..This study will examine how Lactobacillus, an essential bacteria for vaginal health, works to decrease the amount of HIV in the female reproductive tract. ..
  35. Anogenital HPV Infection in a Population-Based Sample of Puerto Rican Women
    Ana Patricia Ortiz; Fiscal Year: 2012
    ....
  36. MicroPET/SPECT/CT animal imaging device for translational research
    Eugene Fine; Fiscal Year: 2010
    ..The increasing utilization of this advanced technology enables job creation through superior means of obtaining scientific information while efficiently reducing animal and environmental destruction. ..
  37. Menstrual Cycle Control of HIV Infection in the Reproductive Tract
    CHARLES ROBERT WIRA; Fiscal Year: 2013
    ....
  38. Development of a Primate Model for Genital Papillomavirus Infection
    Robert D Burk; Fiscal Year: 2010
    ....
  39. Clinical Epidemiology and Pathogenesis of Asymptomatic HSV
    Anna Wald; Fiscal Year: 2013
    ....
  40. Haiti Research Training Program in the Prevention of AIDS Cervical Cancer
    Daniel W Fitzgerald; Fiscal Year: 2013
    ..abstract_text> ..
  41. Metabolic Engineering for Microbial Taxol Biosynthesis
    Gregory Stephanopoulos; Fiscal Year: 2012
    ..Additionally, a heterologous taxol biosynthetic pathway would drastically expand the opportunities of biosynthesizing a vast diversity of taxol derivatives with greater efficacy and broader anticancer properties. ..
  42. "Physical and Chemical Cues that Guide Sperm Migration"
    Mingming Wu; Fiscal Year: 2013
    ..Binding is reduced by capacitation, so we propose to test its effects on BSPs and on release of sperm from oviductal epithelium, as well as the role that the interactions of BSPs with ANXAs could play in guiding sperm to the egg. ..
  43. HPV Persistence and Head and Neck Cancer
    LUBOMIR TUREK; Fiscal Year: 2013
    ..These results will have direct impact on potential therapeutic strategies to eliminate persistent HPV infection before the development of cancer. ..
  44. Modulation of Hormonal and Systemic Immunity by Hormonal Contraceptive Use
    Thomas L Cherpes; Fiscal Year: 2013
    ....
  45. Brown/WIH Eunice Kennedy Shriver NICHD MFM Units Network Site
    Dwight J Rouse; Fiscal Year: 2013
    ..Brown/WIH, by participating in the MFMU Network, can help provide the necessary, highest quality scientific evidence and redress these burdens. ..
  46. Complement and hormone receptor modulation during gonococcal cervical infection
    Jennifer L Edwards; Fiscal Year: 2010
    ..The proposed studies are an important and under-investigated area of bacterial pathogenesis and are directly applicable to the human health. ..
  47. Cancer Control Research Training Summer Institute
    GRAHAM A contact COLDITZ; Fiscal Year: 2010
    ..It will develop lasting multidisciplinary collaborative relationships between Washington University and INCAN that will lead to design and implementation of policy relevant to cancer control research. ..
  48. A macaque model for endometriosis induced pelvic pain and infertility
    Ov D Slayden; Fiscal Year: 2013
    ....
  49. Elastic Fiber Homeostasis in the Vaginal Wall
    Hiromi Yanagisawa; Fiscal Year: 2013
    ....
  50. POTENTIATING AN HIV DNA VACCINE WITH FLAGELLIN AT THE CERVICAL/VAGINAL MUCOSA
    Dinesh Singh; Fiscal Year: 2011
    ..abstract_text> ..
  51. Novel biologic markers of treatment resistance in locally advanced cervical carci
    Krishnansu Sujata Tewari; Fiscal Year: 2012
    ....
  52. Diagnosis of Cervical Precancers Using Raman Spectroscopy
    Anita Mahadevan-Jansen; Fiscal Year: 2012
    ..With the success of this technique, Raman spectroscopy can be applied to other organ sites such as the prostate and ovary as well as other diseases thus impacting a broader field in medicine. ..
  53. Defining Gene Expression Programs in Cervical Ripening: Roles for Non-Coding RNAs
    Mala S Mahendroo; Fiscal Year: 2013
    ....
  54. The role of signal transduction cascades in mediating papillomavirus infection.
    CYNTHIA YVONNE ABBAN; Fiscal Year: 2012
    ..The goal of our research is to investigate the process by which the virus binds and utilizes the human cells to multiply. Ultimately, our goal is to decipher means of terminating HPV infection thus preventing cancer. ..
  55. Translating Cancer Prevention Research in the Developing World
    Madhuri Kakarala; Fiscal Year: 2011
    ....
  56. Revealing the role of the cervico-vaginal microbiome in spontaneous preterm birth
    Michal A Elovitz; Fiscal Year: 2013
    ..In addition, we will comprehensively assess if behavioral, social and/or environmental factors modify the CV microbiota and/or its association with PTB. ..
  57. A Novel Approach for the Routine Screening for Ovarian Cancer
    Lewis K Pannell; Fiscal Year: 2013
    ..One aim examines a self-taken test that could allow its use in medically underrepresented and rural areas. ..
  58. Papillomavirus Host Interation
    Neil D Christensen; Fiscal Year: 2013
    ..The goal of this research project is to optimize approaches to induce immunotherapeutic T-cell immune responses that can eliminate existing HPV infections and associated cancers. ..
  59. Cervical, Anal &Oral HPV Persistence/Adolescent Girls
    NICOLAS SCHLECHT; Fiscal Year: 2013
    ....
  60. NEAR INFRARED IMAGING OF MMP-2/MM-9 WITH A HIGHLY SPECIFIC OPTICAL PROBE
    WILSON EDWARDS; Fiscal Year: 2009
    ..Ultimately, these agents will allow for rapid and non-invasive or minimally invasive diagnosis of cancer. ..
  61. The Early Events Determining SIV Rectal Transmission
    Qingsheng Li; Fiscal Year: 2013
    ..abstract_text> ..
  62. Multiresolution FLIM and Reflectance Confocal Microscopy to Detect Dysplasia
    KRISTEN CARLSON MAITLAND; Fiscal Year: 2013
    ..Early detection is thus critical. The goal of the proposed research is to develop a novel optical imaging tool to improve early detection of precancerous lesions in the oral cavity. ..
  63. Salpingeal infection model of Mycoplasma genitalium
    Patricia A Totten; Fiscal Year: 2010
    ..genitalium in an animal and in tissues most closely related to human disease. Further, development of this model will provide future opportunity to assess strategies for prevention and treatment of this emerging pathogen. ..
  64. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2001
    ..The results from this study will be related to the prevention and education of pre-cancer and cancer lesions in adolescents infected with HIV. ..
  65. EFFECTS OF BENZO[A]PYRENE IN TRANSGENIC MODEL OF CERVICA
    ELLEN RORKE; Fiscal Year: 2002
    ..Use of our novel transgenic model provides an innovative approach for addressing these questions. ..
  66. PREGNANCY OUTCOME AFTER TREATMENT OF CERVICAL DYSPLASIA
    Lynn Sadler; Fiscal Year: 2001
    ..Outcome of the first >/= 20 week pregnancy following diagnosis will be compared for 535 treated women and 535 women not requiring treatment, using multiple logistic and linear regression models to control for confounding. ..
  67. Hormonal Regulation of the Cervix During Pregnancy
    ORRIN SHERWOOD; Fiscal Year: 2006
    ..Treatment with RU 486 alone and in combination with exogenous relaxin will be done at term with relaxin-deficient rats. ..
  68. NITRIC OXIDE AND CERVICAL RIPENING
    James Schreiber; Fiscal Year: 1999
    ..This information will further our basic understanding of the regulation of collagenase activity and are critical for development of future therapies for the prevention of preterm labor. ..
  69. STRETCH CHANGES IN THE RABBIT CERVIX BY PROSTAGLANDIN
    John Conrad; Fiscal Year: 1980
    ..Strips of the cervix will be stretched and the stress-strain curves evaluated by linear regression analysis to obtain a single parameter, the stretch modulus, and this will be used to compare the various drugs and treatments. ..
  70. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..
  71. Improving Cancer Outcomes for African-Americans
    Patrick Maguire; Fiscal Year: 2007
    ..abstract_text> ..
  72. DIET AND CANCER IN CHINA
    Colin Campbell; Fiscal Year: 1993
    ..Another 1800 comparable questionnaires and biological specimens will be similarly processed in Taiwan.)..
  73. PEROXISOME PROLIFERATOR INDUCED HEPATOCARCINOGENESIS
    Sambasiva Rao; Fiscal Year: 2004
    ..abstract_text> ..
  74. Molecular epidemiology of cervical adenocarcinoma
    Hans Olov Adami; Fiscal Year: 2007
    ..of this project is to improve the biologic understanding of adenocarcinoma and adenosquamous cancer of the cervix uteri (in the following referred to as adenocarcinoma) through investigation of its viral etiology, and genes ..
  75. FIBRIL ASSOCIATED COLLAGENS IN CERVICAL DILATION
    ANDREA WESTERHAUSEN LARSON; Fiscal Year: 1999
    The cervix uteri is characterized by a high content of collagen. During most of gestation its rigidity ensures retention of the conceptus...
  76. Enhanced Single-Visit Cervical Cancer Screening Program
    Hoda Anton Culver; Fiscal Year: 2007
    ..The incremental net cost associated with an incremental improvement in outcomes in terms of quality-adjusted life years (QALYs) will be measured. [unreadable] [unreadable]..