cervix uteri

Summary

Summary: The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.

Top Publications

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  2. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
  3. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
  4. doi Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
  5. ncbi Patterns of known and novel small RNAs in human cervical cancer
    Weng Onn Lui
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Cancer Res 67:6031-43. 2007
  6. pmc Improved amplification of genital human papillomaviruses
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA
    J Clin Microbiol 38:357-61. 2000
  7. ncbi Progesterone and the risk of preterm birth among women with a short cervix
    Eduardo B Fonseca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    N Engl J Med 357:462-9. 2007
  8. ncbi Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells
    R N Fichorova
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 60:508-14. 1999
  9. ncbi The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission
    R N Fichorova
    Fearing Research Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Thorn 217, Boston, MA 02115, USA
    J Infect Dis 184:418-28. 2001
  10. pmc Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial
    S S Hassan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Ultrasound Obstet Gynecol 38:18-31. 2011

Detail Information

Publications322 found, 100 shown here

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  2. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
    ....
  3. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  4. doi Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
    ..These psychosocial aspects and the need for more information and educational programmes about HPV are also discussed in this article...
  5. ncbi Patterns of known and novel small RNAs in human cervical cancer
    Weng Onn Lui
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Cancer Res 67:6031-43. 2007
    ..In addition to the known miRNAs, we found a number of novel miRNAs and an additional set of small RNAs that do not meet miRNA criteria...
  6. pmc Improved amplification of genital human papillomaviruses
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA
    J Clin Microbiol 38:357-61. 2000
    ..This new primer system will be useful in assessing the natural history of HPV infections, particularly when the analysis requires HPV typing...
  7. ncbi Progesterone and the risk of preterm birth among women with a short cervix
    Eduardo B Fonseca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    N Engl J Med 357:462-9. 2007
    ..Asymptomatic women found at midgestation to have a short cervix are at greatly increased risk for spontaneous early preterm delivery, and it is unknown whether progesterone reduces this risk in such women...
  8. ncbi Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells
    R N Fichorova
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 60:508-14. 1999
    ....
  9. ncbi The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission
    R N Fichorova
    Fearing Research Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Thorn 217, Boston, MA 02115, USA
    J Infect Dis 184:418-28. 2001
    ..Furthermore, this study identifies in vitro and in vivo model systems for monitoring undesirable proinflammatory effects of microbicides and other vaginal products...
  10. pmc Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial
    S S Hassan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Ultrasound Obstet Gynecol 38:18-31. 2011
    ..This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix...
  11. ncbi Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus
    Nicolas Nagot
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    N Engl J Med 356:790-9. 2007
    ..Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility...
  12. doi Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers
    A Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    J Proteome Res 10:5139-49. 2011
    ..This comprehensive systems biology approach identifies mucosal serpins and cystatins as novel correlates of HIV-1-resistance. This represents the first study characterizing these factors in the female genital tract...
  13. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
    ..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
  14. pmc Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    C A Gaydos
    Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
    J Clin Microbiol 48:3236-43. 2010
    ..trachomatis and N. gonorrhoeae dual detection with high sensitivity and specificity. The automated assay provides a useful alternative nucleic acid amplification assay for clinical laboratories and clinicians...
  15. pmc Human papillomavirus infection and cervical cytology in HIV-infected and HIV-uninfected Rwandan women
    Diljeet K Singh
    Division of Gynecologic Oncology, Feinberg School of Medicine, Northwestern University, and Cook County Hospital, Chicago, Illinois 60611, USA
    J Infect Dis 199:1851-61. 2009
    ..Data on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs...
  16. ncbi Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells
    David J Sharkey
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Mol Hum Reprod 13:491-501. 2007
    ..Seminal factor regulation of inflammatory cytokines in the cervical epithelium is implicated in controlling the immune response to seminal antigens, and defence against infectious agents introduced at intercourse...
  17. ncbi Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion
    Yali Zhai
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cancer Res 67:10163-72. 2007
    ..Other genes with differential expression in invasive SCC versus HSIL may contribute to tumor progression or may be useful as markers for cancer diagnosis or progression risk...
  18. pmc Association of HIV infection with distribution and viral load of HPV types in Kenya: a survey with 820 female sex workers
    Stanley M F Luchters
    International Centre for Reproductive Health ICRH, Ghent University, Belgium
    BMC Infect Dis 10:18. 2010
    ..Interactions between these infections pose substantial public health challenges, especially where HIV prevalence is high and HPV vaccine coverage low...
  19. pmc Prevalence of type-specific HPV infection by age and grade of cervical cytology: data from the ARTISTIC trial
    A Sargent
    Division of Cancer Studies and Imaging, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Br J Cancer 98:1704-9. 2008
    ..In the absence of broader cross-protection, the large majority of low-grade and many high-grade abnormalities may still occur in sexually active vaccinated women...
  20. ncbi Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia
    Marc Arbyn
    European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
    J Natl Cancer Inst 96:280-93. 2004
    ..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
  21. pmc Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
    Barry R O'Keefe
    Molecular Targets Development Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:6099-104. 2009
    ..Moreover, GRFT-P is potently active in preventing infection of cervical explants by HIV-1 and has no mitogenic activity on cultured human lymphocytes...
  22. ncbi Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G
    Bradley J Catalone
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biomed Pharmacother 59:430-7. 2005
    ..These results provide further insight into the activity of C31G, as well as mechanisms potentially associated with microbicide toxicity...
  23. doi Molecular methods for a correct diagnosis of multiple HPV infections and clinical implications for vaccine
    Andrea Tinelli
    Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Department of Obstetrics and Gynaecology, Vito Fazzi Hospital, 73100 Lecce, Italy
    Int J Gynecol Cancer 21:545-50. 2011
    ..The aim of this study was to detect the HPV coinfections and the inner genotype in a series of 336 cervical-vaginal samples...
  24. doi Search for cellular partners of human papillomavirus type 16 E2 protein
    Agnieszka K Olejnik-Schmidt
    Department of Biotechnology and Food Microbiology, August Cieszkowski University of Agriculture, Wojska Polskiego Street No 48, 60 627 Poznan, Poland
    Arch Virol 153:983-90. 2008
    ..Using a yeast two-hybrid system, we have identified epithelial cellular proteins that bind to the E2 protein of HPV16...
  25. doi HPV genotypes in women with squamous intraepithelial lesions and normal cervixes participating in a community-based microbicide study in Pretoria, South Africa
    H M Said
    Faculty of Health Science, Department of Medical Microbiology, University of Pretoria, South Africa
    J Clin Virol 44:318-21. 2009
    ..Little is known regarding the human papillomaviruses (HPV) genotypes prevalent in women in South Africa, a country with a high incidence of cervical cancer...
  26. doi Robotic uterine artery preservation and nerve-sparing radical trachelectomy with bilateral pelvic lymphadenectomy in early-stage cervical cancer
    Dae Gy Hong
    Department of Obstetrics and Gynecology, Kyungpook National University, Daegu, Korea
    Int J Gynecol Cancer 21:391-6. 2011
    ..The aim of the study was to evaluate the safety and feasibility of robotic uterine artery preservation and nerve-sparing radical trachelectomy with pelvic lymphadenectomy using the da Vinci surgical system...
  27. doi High-risk human papillomavirus reactivation in human immunodeficiency virus-infected women: risk factors for cervical viral shedding
    Regan N Theiler
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77550 0587, USA
    Obstet Gynecol 115:1150-8. 2010
    ..To evaluate the presence of and estimate risk factors for reactivation of latent high-risk human papillomavirus (HPV) cervical infection in human immunodeficiency virus (HIV)-infected and HIV-uninfected women...
  28. ncbi Comparison of AMPLICOR and Hybrid Capture II assays for high risk HPV detection in normal and abnormal liquid-based cytology: use of INNO-LiPA Genotyping assay to screen the discordant results
    L Z Mo
    EA3181, IFR133, Universite de Franche Comte, 25000 Besancon, France
    J Clin Virol 41:104-10. 2008
    ..6%) and specificity (100%) of AMPLICOR was similar to that of HCII Test. The AMPLICOR HPV Test is sensitive, specific, feasible and appropriate for routine HPV detection...
  29. pmc Prevalence and risk profile of cervical Human papillomavirus infection in Zhejiang Province, southeast China: a population-based study
    Jing Ye
    Women s Reproductive Health Key Laboratory of Zhejiang Province, Women s Hospital, School of Medicine, Zhejiang University, Xueshi Rd 2, Hangzhou, PR China
    Virol J 7:66. 2010
    ..Here, we investigated the prevalence of cervical HPV infection, as well as predictors concerned, in Zhejiang Province, southeast China...
  30. ncbi Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarker
    Ralf Hilfrich
    Cytoimmun Diagnostics, Pirmasens, Germany
    Anal Quant Cytol Histol 30:78-82. 2008
    ..To proof the prognostic relevance of HPV L1 capsid protein detection on colposcopically-guided punch biopsies in combination with p16...
  31. doi Fertility-preserving surgical procedures for patients with gynecologic malignancies
    Nabila Rasool
    Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Obstet Gynecol 53:804-14. 2010
    ....
  32. pmc Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa
    Craig R Cohen
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94117, USA
    AIDS 24:2069-74. 2010
    ..To determine whether healthy, young women in sub-Saharan Africa have a more activated immune milieu in the genital tract (i.e. activated CD4 T cells) than a similar population in the United States...
  33. pmc Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length
    John Owen
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249 7333, USA
    Am J Obstet Gynecol 201:375.e1-8. 2009
    ..The objective of the study was to assess cerclage to prevent recurrent preterm birth in women with short cervix...
  34. pmc Abundance of multiple high-risk human papillomavirus (HPV) infections found in cervical cells analyzed by use of an ultrasensitive HPV genotyping assay
    Markus Schmitt
    Department of Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg 69120, Germany
    J Clin Microbiol 48:143-9. 2010
    ..As a consequence, PCR-TS-MPG appears to be highly suited for analysis of the significance of multiple infections in the development of cervical cancer and for the study the natural history and the latency of HPV...
  35. pmc Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 76:9868-76. 2002
    ....
  36. pmc Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification tests
    E Van Dyck
    STD HIV Research and Intervention Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    J Clin Microbiol 39:1751-6. 2001
    ..trachomatis EIA. The accuracies of the different NAATs were quite similar. SDA was the only amplification assay with 100% specificity for detection of both N. gonorrhoeae and C. trachomatis in endocervical specimens...
  37. pmc Enhanced detection and typing of human papillomavirus (HPV) DNA in anogenital samples with PGMY primers and the Linear array HPV genotyping test
    Francois Coutlee
    Laboratoire de Virologie Moléculaire du Centre de Recherche, Departement De Microbiologie et Infectiologie, Hôpital Notre Dame du Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    J Clin Microbiol 44:1998-2006. 2006
    ..06; P = 0.57), CD4 cell counts (r = 0.06 +/- 0.06; P = 0.13), or the grade of anal disease (r = -0.11 +/- 0.06; P = 0.07). LA-HPV compared favorably with PGMY-LB but yielded higher detection rates for newer and well-known HPV types...
  38. pmc Comparing first-void urine specimens, self-collected vaginal swabs, and endocervical specimens to detect Chlamydia trachomatis and Neisseria gonorrhoeae by a nucleic acid amplification test
    Mary Ann Shafer
    Division of Adolescent Medicine, Department of Pediatrics, University of California, San Francisco 94143, USA
    J Clin Microbiol 41:4395-9. 2003
    ..Self-collected vaginal swab collections are a feasible alternative to cervical specimen collections in this population, and the use of multiple types of specimens increases the positive yield markedly...
  39. ncbi The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study
    Monica Molano
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Infect Dis 191:907-16. 2005
    ..4 [95% CI, 0.1-0.9]), compared with that for serovars of the intermediate group (F and G). At 4 years of follow-up, 94% of the women had cleared their infections...
  40. pmc Type-specific cervico-vaginal human papillomavirus infection increases risk of HIV acquisition independent of other sexually transmitted infections
    Karen K Smith-McCune
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e10094. 2010
    ..The objective of this study was to determine whether cervico-vaginal HPV infection increases the risk of HIV acquisition in women independent of other common STIs...
  41. ncbi Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea
    Hai Rim Shin
    Research Institute, National Cancer Center, Goyang si, Gyeonggi Do, Republic of Korea
    J Infect Dis 190:468-76. 2004
    ..Little is known about the prevalence of human papillomavirus (HPV) infection in young adults in Asia...
  42. pmc Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection
    Richard M Novak
    University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
    Clin Vaccine Immunol 14:1102-7. 2007
    ..However, the increased RANTES levels in a higher-risk subset of high-risk women were reduced after BV treatment...
  43. pmc Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection
    Pamela P Gumbi
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Virol 82:8529-36. 2008
    ..In addition, we further show that inflammatory cytokines are associated with increased levels of HIV-specific CD8 effector cells at the genital mucosa but that these were not able to control genital HIV shedding...
  44. pmc Highly effective detection of human papillomavirus 16 and 18 DNA by a testing algorithm combining broad-spectrum and type-specific PCR
    Leen Jan van Doorn
    DDL Diagnostic Laboratory, Fonteijnenburghlaan 5, 2275 CX, Voorburg, The Netherlands
    J Clin Microbiol 44:3292-8. 2006
    ..This combination of assays is more accurate than either method alone, and the novel algorithm offers a highly accurate and effective method for the analysis of HPV infections...
  45. ncbi Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers
    Shehzad M Iqbal
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Infect Dis 192:728-38. 2005
    ..This is the first study to show elevated levels of beta chemokines and CD4+ T cells in the genital tracts of women who are exposed to HIV-1 and yet are uninfected...
  46. pmc Use of PGMY primers in L1 consensus PCR improves detection of human papillomavirus DNA in genital samples
    Francois Coutlee
    Laboratoire de Virologie Moleculaire, Centre de Recherche et Département de Microbiologie et Infectiologie, Hôpital Notre Dame du Centre Hospitalier de l Université de Montréal, Canada
    J Clin Microbiol 40:902-7. 2002
    ..Studies using PGMY instead of MY primers have the potential to report higher detection rates of HPV infection not only for newer HPV types but also for well-known genital types...
  47. ncbi Detection of bacterial vaginosis-related organisms by real-time PCR for Lactobacilli, Gardnerella vaginalis and Mycoplasma hominis
    M Reza Zariffard
    Department of Immunology Microbiology, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
    FEMS Immunol Med Microbiol 34:277-81. 2002
    ....
  48. pmc Human Papillomavirus (HPV) infection in pregnant women and mother-to-child transmission of genital HPV genotypes: a prospective study in Spain
    Xavier Castellsague
    Unit of Infections and Cancer UNIC, Cancer Epidemiology Research Program CERP, IDIBELL Institut Català d Oncologia ICO, Hospitalet de Llobregat, Barcelona, Spain
    BMC Infect Dis 9:74. 2009
    ..Studies on HPV infection in pregnant women and HPV transmission to the child have yielded inconsistent results...
  49. ncbi Aberrant methylation during cervical carcinogenesis
    A K Virmani
    Hamon Center for Therapeutic Oncology Research, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas 85930, USA
    Clin Cancer Res 7:584-9. 2001
    ....
  50. ncbi A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions
    Elizabeth R Boskey
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Sex Transm Dis 30:107-9. 2003
    ..A convenient method for self-sampling these secretions outside a clinical setting can facilitate such studies of reproductive health...
  51. ncbi Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone
    Jeffrey Pudney
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 73:1253-63. 2005
    ....
  52. ncbi PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 193:27-35. 2006
    ..This study was designed to determine the antiviral activity in cervicovaginal lavage (CVL) samples collected after intravaginal application of 0.5% PRO 2000 gel (Indevus)...
  53. pmc Transmission of human papillomavirus in heterosexual couples
    Brenda Y Hernandez
    University of Hawaii, Manoa, HI 96813, USA
    Emerg Infect Dis 14:888-94. 2008
    ..Couples who transmitted HPV were more sexually active and used condoms less frequently. These results have implications for HPV prevention and control strategies, including the targeting of prophylactic vaccines...
  54. doi Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models
    Viviana Buffa
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s Hospital, University of London, London SW17 0RE, UK
    J Gen Virol 90:234-43. 2009
    ..Data presented here indicate that targeting HIV envelope glycoproteins may provide an effective strategy to prevent HIV-1 infection mediated by either cell-free virus or infected cells...
  55. ncbi Evaluation of quadrivalent HPV 6/11/16/18 vaccine efficacy against cervical and anogenital disease in subjects with serological evidence of prior vaccine type HPV infection
    Sven Eric Olsson
    Karolinska Institute at Danderyd Hospital, Stockholm, Sweden
    Hum Vaccin 5:696-704. 2009
    ..Vaccine tolerability in this previously infected population was also assessed...
  56. doi The effect of 17α-hydroxyprogesterone caproate on preterm birth in women with an ultrasound-indicated cerclage
    Timothy J Rafael
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Am J Perinatol 28:389-94. 2011
    ..72, 95% confidence interval 0.50 to 5.89), nor did it have a significant effect on the secondary outcomes. Among women with a prior spontaneous PTB and current UIC for CL < 25 mm, 17P did not reduce the rate of PTB < 35 weeks...
  57. pmc The combination of the gastrointestinal integrin (α4β7) and selectin ligand enhances T-Cell migration to the reproductive tract during infection with Chlamydia trachomatis
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Am J Reprod Immunol 61:446-52. 2009
    ..Identifying a population of endocervical T-cells to target in vaccine development is likely to enhance efficacy of a vaccine and reduce reproductive tract dysfunction...
  58. ncbi Evaluation of effectiveness of prophylactic cerclage of a short cervix according to interleukin-8 in cervical mucus
    Masatoshi Sakai
    Department of Obstetrics, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Obstet Gynecol 194:14-9. 2006
    ..This study was undertaken to compare rates of preterm delivery according to cervical mucus interleukin-8 (IL-8) among women who underwent cerclage because of a short cervix...
  59. doi Prevalence, evolution, and features of infection with human papillomavirus: a 15-year longitudinal study of routine screening of a women population in the north of Spain
    Maria de Ona
    Unit of Virology, Hospital Universitario de Asturias, Oviedo, Asturias, Spain
    J Med Virol 82:597-604. 2010
    ..The low 3-year (even 5-year) cumulative incidence rate of HPV infection suggests that cervical screening every 3 (or even 5) years is safe and effective...
  60. ncbi A study of the morphological parameters of cervical squamous epithelium
    D C Walker
    Medical Physics and Engineering, University of Sheffield, Floor I, Royal Hallamshire Hospital, Glossop Road, Sheffield S 10 2JF, UK
    Physiol Meas 24:121-35. 2003
    ..We therefore present the results of our own basic image analysis on normal and pathological tissue sections, which we hope will be of use to other workers wishing to model cervical squamous epithelium, or other similar tissue structures...
  61. doi Prevalence and type distribution of high-risk human papillomavirus infection in women undergoing voluntary cervical cancer screening in Italy
    Alberto Agarossi
    Department of Obstetrics and Gynecology, Clinical Science Institute, L Sacco Hospital, University of Milan, Milan, Italy
    J Med Virol 81:529-35. 2009
    ..The findings of this study may contribute to reliable predictions on the potential efficacy of an HPV vaccine in clinical practice...
  62. doi Identification of a novel human papillomavirus type 16 E1 gene variant with potentially reduced oncogenicity
    Ivan Sabol
    Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
    J Med Virol 80:2134-40. 2008
    ..5% and 18.6%, respectively) can only be ascribed to the effect of this particular HPV variant. Further research is needed to clarify the biology of these HPV 16 E1 variants...
  63. pmc Higher levels of cervicovaginal inflammatory and regulatory cytokines and chemokines in healthy young women with immature cervical epithelium
    Loris Y Hwang
    University of California San Francisco, Department of Pediatrics, Division of Adolescent Medicine, 3333 California Street, Suite 245, San Francisco, CA 94118, USA
    J Reprod Immunol 88:66-71. 2011
    ..Cytokine profiles in the healthy state may foreshadow differential responses to pathogens. Cervical epithelial type should be measured in clinical studies involving cervicovaginal immune markers...
  64. pmc Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T cell responses in the cervix
    Duncan Chege
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e13077. 2010
    ..Nonetheless, this platform may have a potential role in measuring mitogen-induced immune responses in the genital tract...
  65. doi Adherence of clinically isolated lactobacilli to human cervical cells in competition with Neisseria gonorrhoeae
    Katarina Vielfort
    Department of Medical Biochemistry and Microbiology, Biomedical Centre, Uppsala University, S 751 23, Uppsala, Sweden
    Microbes Infect 10:1325-34. 2008
    ..Taken together, we reveal novel data regarding gonococcal and lactobacilli competition for adherence that will benefit future gonococcal prevention and treatments...
  66. ncbi Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Am J Surg Pathol 30:209-15. 2006
    ..Possible theories of histogenesis include a developmental anomaly, metaplasia of preexisting endocervical glands, and derivation from mesonephric remnants...
  67. ncbi HPV DNA detection and typing in cervical scrapes
    Peter J F Snijders
    Section Molecular Pathology, Department of Pathology, VU University Medical Center, The Netherlands
    Methods Mol Med 119:101-14. 2005
    ....
  68. pmc Cervical smears and human papillomavirus typing in sex workers
    R Mak
    Department of Public Health, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium and PASOP VZW, Sex Workers Health Centre, Brabantdam 100B, 9000 Ghent, Belgium
    Sex Transm Infect 80:118-20. 2004
    ..The aim of this study is to assess risks for abnormal cervical smears and HPV in sex workers and decide whether the current screening policy is sufficient for them...
  69. doi Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus
    David J Sharkey
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Immunol 188:2445-54. 2012
    ..This response is also relevant to transmission of sexually transmitted pathogens and potentially, susceptibility to cervical metaplasia...
  70. pmc Use of human tissue explants to study human infectious agents
    Jean Charles Grivel
    Section of Intercellular Interactions, Program on Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 10 Centre Drive, Room 9D58, Bethesda, Maryland 20892, USA
    Nat Protoc 4:256-69. 2009
    ..Using this protocol, culture and infections can be set up in 3-6 h and be maintained for 2-3 weeks, depending on the tissue used...
  71. ncbi T-lymphocyte profile and total and virus-specific immunoglobulin concentrations in the cervix of HIV-1-infected women
    Alison J Quayle
    Department of Immunology, Microbiology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Acquir Immune Defic Syndr 44:292-8. 2007
    ..The mucosal lymphocyte population is the largest in the body, and the gastrointestinal compartment has been well characterized in HIV infection. Much less is known about the effects of HIV on the genital tract...
  72. pmc Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
    Samuel K Lai
    Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 107:598-603. 2010
    ....
  73. pmc Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract
    Kei Kawana
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 76:3011-8. 2008
    ..trachomatis infection. Basal deficiency in CD1d-mediated immune responsiveness may result in susceptibility to sexually transmitted agents. Decreased CD1d-mediated signaling may help C. trachomatis evade detection by innate immune cells...
  74. ncbi Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women
    M Prakash
    Department of Immunology, Imperial College of Science Technology and Medicine (ICSTM) at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    J Reprod Immunol 52:101-11. 2001
    ..Thus, the preferential transmission of macrophage tropic strains of HIV-1 following sexual contact cannot be explained solely on the expression of chemokine co-receptors by T lymphocyte subsets...
  75. ncbi Human papillomavirus E6/E7 mRNA expression in women younger than 30 years of age
    T Molden
    Institute of Pathology, National University Hospital, 0027 Oslo, Norway
    Gynecol Oncol 100:95-100. 2006
    ..It is not clear, however, to what extent the E6/E7 transcripts are being expressed. This may be of prognostic importance. In this study, we have determined the prevalence of HPV DNA and mRNA in 283 women younger than 30 years of age...
  76. pmc Prevalence, distribution and correlates of endocervical human papillomavirus types in Brazilian women
    S A Lippman
    Population Council, New York, NY, USA
    Int J STD AIDS 21:105-9. 2010
    ..Additional studies mapping the distribution of HPV types worldwide are necessary to prepare for vaccination programmes and direct future vaccine development...
  77. ncbi Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis
    G M Clifford
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Lancet 366:991-8. 2005
    ..We aimed to compare HPV-type distribution in representative samples of women from different world regions...
  78. pmc Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tract
    Alfred Bere
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
    Immunology 130:23-33. 2010
    ..We conclude that cervical Gag-specific T-cell responses in expanded lines are most easily detectable in women who have corresponding high-magnitude Gag-specific T-cell responses in blood...
  79. pmc A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2
    Christophe Vanpouille
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 201:635-43. 2010
    ..However, both antiviral activities of acyclovir are dependent on phosphorylation by the nucleoside kinase activity of coinfecting human herpesviruses...
  80. pmc Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection
    L Falk
    Department of Dermatology and Venereology, University Hospital, Orebro, SE 701 85 Orebro, Sweden
    Sex Transm Infect 81:73-8. 2005
    ....
  81. pmc Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes
    M Nees
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
    J Virol 75:4283-96. 2001
    ..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
  82. ncbi Quantitative ex vivo analysis of functional virus-specific CD8 T lymphocytes in the blood and genital tract of HIV-infected women
    Rupert Kaul
    Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
    AIDS 17:1139-44. 2003
    ..The induction and monitoring of mucosal CD8 cell responses will be an important component of HIV-1 vaccine trials, but information regarding the frequency, phenotype and function of genital tract CD8 cell responses is lacking...
  83. ncbi The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workers
    Dianne Marais
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
    Virus Res 121:220-2. 2006
    ..5 95% CI 1.0-11.8). We conclude that the use of nonoxynol-9 did not prevent genital HPV infection and could increase the virus' ability to infect or persist...
  84. pmc Multicenter evaluation of the BDProbeTec ET System for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine specimens, female endocervical swabs, and male urethral swabs
    B Van Der Pol
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Microbiol 39:1008-16. 2001
    ....
  85. ncbi Human papillomavirus testing on self-sampled cervicovaginal brushes: an effective alternative to protect nonresponders in cervical screening programs
    Aagje G Bais
    Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 120:1505-10. 2007
    ..euro 7,599). Offering self-sampling for hrHPV testing in nonresponders is an attractive adjunct to effectively increase population coverage of screening without the adverse effect of markedly increased costs per detected CIN2+ lesion...
  86. pmc Assessment of MagNA pure LC extraction system for detection of human papillomavirus (HPV) DNA in PreservCyt samples by the Roche AMPLICOR and LINEAR ARRAY HPV tests
    Matthew P Stevens
    Department of Microbiology, The Royal Women s Hospital, and Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    J Clin Microbiol 44:2428-33. 2006
    ....
  87. ncbi Is sonographic assessment of cervical length better than digital examination in screening for preterm delivery in a low-risk population?
    Ratko Matijevic
    Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Sveti Duh Hospital, Zagreb, Croatia
    Acta Obstet Gynecol Scand 85:1342-7. 2006
    ....
  88. ncbi Computerized planimetry versus clinical assessment for the measurement of cervical ectopia
    C S Morrison
    Clinical Research Division, Family Health International, Research Triangle Park, North Carolina 27709, USA
    Am J Obstet Gynecol 184:1170-6. 2001
    ..Clinical assessment of cervical ectopia may be used when computer planimetry is not available...
  89. pmc Prevalence and risk factors of cervicovaginal HIV shedding among HIV-1 and HIV-2 infected women in Dakar, Senegal
    K Seck
    , IHS, Dakar, , , France
    Sex Transm Infect 77:190-3. 2001
    ..2 (0.5-2.9)). CONCLUSION: Advanced disease stage and immunosuppression are the major risk determinants for shedding of both HIV-1 and HIV-2. Basic vaginal pH is also a risk determinant for HIV-1 shedding...
  90. ncbi Comparison of human papillomavirus DNA tests, liquid-based cytology and conventional cytology for the early detection of cervix uteri cancer
    Vania R Girianelli
    Brazilian National Cancer Institute, Rua dos Inválidos, Rio de Janeiro, RJ, Brazil
    Eur J Cancer Prev 15:504-10. 2006
    ..professional and self-collected) and liquid-based cytology with conventional cytology in the detection of cervix uteri cancer and its precursor lesions...
  91. ncbi The impact of syndromic treatment of sexually transmitted diseases on genital shedding of HIV-1
    Dawit Wolday
    Ethio Netherlands AIDS Research Project ENARP, the Department of Gynaecology and Obstetrics, Black Lion Teaching Hospital, Addis Ababa, Ethiopia
    AIDS 18:781-5. 2004
    ..To examine the impact of sexually transmitted diseases (STD) syndromic treatment on genital shedding of HIV and the impact among women in whom STD treatment was not successful...
  92. ncbi Joint effects of different human papillomaviruses and Chlamydia trachomatis infections on risk of squamous cell carcinoma of the cervix uteri
    T Luostarinen
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Box 169, FIN 00171 Helsinki, Finland
    Eur J Cancer 40:1058-65. 2004
    ..Possible explanations for the observed antagonism include misclassification, selection bias or a true biological phenomenon with HPV6/11 and C. trachomatis exposures antagonizing the carcinogenic effects of HPV16...
  93. ncbi Human papillomavirus DNA detection in women with primary abnormal cytology of the cervix: prevalence and distribution of HPV genotypes
    E Beerens
    Department of Pathology, Ghent University Hospital, Belgium
    Cytopathology 16:199-205. 2005
    ....
  94. doi HPV31 and HPV33 incidence in cervical samples from women in Recife, Brazil
    M F P T Baldez da Silva
    Departamento de Genetica, Laboratório de Estudos Moleculares e Terapia Experimental, Universidade Federal de Pernambuco, Recife, PE, Brasil
    Genet Mol Res 8:1437-43. 2009
    ..There was a strong prevalence of HPV16 and a high incidence of HPV types 31 and 33. These data foster the discussion about the need to evaluate viral prevalence in each geographic region in order to develop targeted vaccine programs...
  95. doi Cervical length at mid-pregnancy and the risk of primary cesarean delivery
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
    N Engl J Med 358:1346-53. 2008
    ..We hypothesized that a long cervix in mid-pregnancy would be associated with an increased risk of cesarean delivery during labor at term...
  96. ncbi Gestational age at cervical length measurement and incidence of preterm birth
    Vincenzo Berghella
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, 834 Chestnut Street, Philadelphia, PA 19107, USA
    Obstet Gynecol 110:311-7. 2007
    ..To estimate the risk of spontaneous preterm birth based on transvaginal ultrasound cervical length and gestational age at which cervical length was measured...
  97. ncbi Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer
    K L Wallin
    Laboratory of Tumor Virus Epidemiology, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 341:1633-8. 1999
    ..Infection with the human papillomavirus (HPV) has been established as a cause of cervical cancer, but the association between a positive test for HPV DNA and the risk of the subsequent development of invasive cervical cancer is unknown...
  98. ncbi Second-trimester cervical ultrasound: associations with increased risk for recurrent early spontaneous delivery
    W W Andrews
    Center for Research in Women s Health, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233 7333, USA
    Obstet Gynecol 95:222-6. 2000
    ..To determine whether short cervical length or internal os funneling before 20 weeks' gestation predicts early preterm birth or pregnancy loss in women with at least one prior spontaneous early preterm birth...
  99. pmc Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women
    Alfred Bere
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    J Immunol Methods 354:68-79. 2010
    ..Irrespective of the expansion method used, the T cell memory profile was altered following expansion...
  100. ncbi Cervical length at 16-22 weeks' gestation and risk for preterm delivery
    J U Hibbard
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Obstet Gynecol 96:972-8. 2000
    ..To determine whether cervical length, as measured by transvaginal sonogram in asymptomatic gravidas at 16-22 weeks, is associated with risk of spontaneous preterm delivery...
  101. ncbi Treatment of cervicitis is associated with decreased cervical shedding of HIV-1
    R S McClelland
    Department of Medicine, University of Washington, Seattle 98104, USA
    AIDS 15:105-10. 2001
    ..Treatment of sexually transmitted diseases may be an important means of decreasing the infectivity of HIV-1 seropositive women by reducing exposure to HIV-1 in genital secretions...

Research Grants87

  1. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ....
  2. HPV & Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2010
    ....
  3. EFFECTS OF BENZO[A]PYRENE IN TRANSGENIC MODEL OF CERVICA
    ELLEN RORKE; Fiscal Year: 2002
    ..Use of our novel transgenic model provides an innovative approach for addressing these questions. ..
  4. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2007
    ..abstract_text> ..
  5. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2007
    ..Duet" covers the cervix for maximum protection of this susceptible site for infections, and delivers microbicide gel to protect both the cervix and vagina. The reusable Duet will be low in cost and useful for low-resource areas. ..
  6. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Dewhirst; Fiscal Year: 2009
    ..The results of this work may lead to targeting the HRHV axis as a unique tumor specific method to treat virtually all forms of solid cancers. ..
  7. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2010
    ..The results of this work may lead to targeting the HRHV axis as a unique tumor specific method to treat virtually all forms of solid cancers. ..
  8. Hormonal Regulation of the Cervix During Pregnancy
    ORRIN SHERWOOD; Fiscal Year: 2006
    ..Treatment with RU 486 alone and in combination with exogenous relaxin will be done at term with relaxin-deficient rats. ..
  9. PREGNANCY OUTCOME AFTER TREATMENT OF CERVICAL DYSPLASIA
    Lynn Sadler; Fiscal Year: 2001
    ..Outcome of the first >/= 20 week pregnancy following diagnosis will be compared for 535 treated women and 535 women not requiring treatment, using multiple logistic and linear regression models to control for confounding. ..
  10. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..
  11. PEROXISOME PROLIFERATOR INDUCED HEPATOCARCINOGENESIS
    Sambasiva Rao; Fiscal Year: 2004
    ..abstract_text> ..
  12. Molecular epidemiology of cervical adenocarcinoma
    Hans Olov Adami; Fiscal Year: 2007
    ..of this project is to improve the biologic understanding of adenocarcinoma and adenosquamous cancer of the cervix uteri (in the following referred to as adenocarcinoma) through investigation of its viral etiology, and genes ..
  13. Enhanced Single-Visit Cervical Cancer Screening Program
    Alberto Manetta; Fiscal Year: 2006
    ..The incremental net cost associated with an incremental improvement in outcomes in terms of quality-adjusted life years (QALYs) will be measured. ..
  14. Enhanced Single-Visit Cervical Cancer Screening Program
    Hoda Anton Culver; Fiscal Year: 2007
    ..The incremental net cost associated with an incremental improvement in outcomes in terms of quality-adjusted life years (QALYs) will be measured. ..