uterus

Summary

Summary: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.

Top Publications

  1. ncbi Molecular cues to implantation
    S K Dey
    Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA
    Endocr Rev 25:341-73. 2004
  2. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
  3. ncbi Insights into the uterus
    Susan Wray
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Exp Physiol 92:621-31. 2007
  4. ncbi The uterine spiral arteries in human pregnancy: facts and controversies
    R Pijnenborg
    Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven, Belgium
    Placenta 27:939-58. 2006
  5. ncbi Multiple female reproductive failures in cyclooxygenase 2-deficient mice
    H Lim
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    Cell 91:197-208. 1997
  6. doi Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 79:1226-36. 2008
  7. pmc Natural killer cell-triggered vascular transformation: maternal care before birth?
    Jianhong Zhang
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada
    Cell Mol Immunol 8:1-11. 2011
  8. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
  9. pmc Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 79:376-86. 2008
  10. ncbi In vivo analysis of progesterone receptor action in the uterus during embryo implantation
    Heather L Franco
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Cell Dev Biol 19:178-86. 2008

Research Grants

  1. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2010
  2. Neurotoxicity of organophosphorus pesticides in developing guinea pigs
    William R Randall; Fiscal Year: 2010
  3. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
  4. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen J Berkley; Fiscal Year: 2010
  5. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
  6. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2010
  7. Novel Treatment of menopausal hot flushes with an extradiol prodrug
    Istvan Merchenthaler; Fiscal Year: 2009
  8. THE ROLE OF THE TYPE 3 DEIODINASE IN DEVELOPMENT
    Donald St Germain; Fiscal Year: 1999
  9. THE ROLE OF THE TYPE 3 DEIODINASE IN DEVELOPMENT
    Donald St Germain; Fiscal Year: 2002
  10. THE ROLE OF THE TYPE 3 DEIODINASE IN DEVELOPMENT
    Donald St Germain; Fiscal Year: 2001

Detail Information

Publications270 found, 100 shown here

  1. ncbi Molecular cues to implantation
    S K Dey
    Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA
    Endocr Rev 25:341-73. 2004
    ..implantation is the result of reciprocal interactions between the implantation-competent blastocyst and receptive uterus. Although various cellular aspects and molecular pathways of this dialogue have been identified, a comprehensive ..
  2. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    ..Prenatal male and female reproductive tract development can therefore occur in the absence of estradiol receptor-mediated responsiveness...
  3. ncbi Insights into the uterus
    Susan Wray
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Exp Physiol 92:621-31. 2007
    ..Study of the physiological mechanisms that produce excitation in the uterus, the subsequent Ca(2)(+) signals and biochemical pathway leading to contraction has underpinned this progress...
  4. ncbi The uterine spiral arteries in human pregnancy: facts and controversies
    R Pijnenborg
    Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven, Belgium
    Placenta 27:939-58. 2006
    ..Several features of the human placental bed are mirrored by processes in other species with haemochorial placentation, and studying such models may help to illuminate poorly understood aspects of human placentation...
  5. ncbi Multiple female reproductive failures in cyclooxygenase 2-deficient mice
    H Lim
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    Cell 91:197-208. 1997
    ....
  6. doi Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 79:1226-36. 2008
    ..IGF1 and IGF2]), their receptors (MET, FGFR2(IIIB), and IGF1R), and IGF binding proteins (IGFBPs) in the ovine uterus. Ewes received daily injections of corn oil vehicle (CO) or 25 mg of P4 in vehicle from 36 h after mating (Day 0) ..
  7. pmc Natural killer cell-triggered vascular transformation: maternal care before birth?
    Jianhong Zhang
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada
    Cell Mol Immunol 8:1-11. 2011
    ..The uterus of early pregnancy is a non-lymphoid organ enriched in NK cells that are specifically recruited to placental ..
  8. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
    ....
  9. pmc Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 79:376-86. 2008
    Gastrin-releasing peptide (GRP) is abundantly expressed by endometrial glands of the ovine uterus and processed into different bioactive peptides, including GRP1-27, GRP18-27, and a C-terminus, that affect cell proliferation and migration...
  10. ncbi In vivo analysis of progesterone receptor action in the uterus during embryo implantation
    Heather L Franco
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Cell Dev Biol 19:178-86. 2008
    ..Therefore, understanding the mechanism of PR action in the adult uterus is necessary in order to understand the events of early pregnancy...
  11. ncbi Neonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouse uterus
    Koji Sato
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Endocr J 56:131-9. 2009
    ..Two loci were cloned, and differential DNA methylation was quantified. Our results indicated that DES altered the expression levels of Dnmts and DNA methylation...
  12. ncbi Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age
    Andrew M Sharkey
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 181:39-46. 2008
    ....
  13. doi Progesterone receptors in the human pregnancy uterus: do they hold the key to birth timing?
    Sam Mesiano
    Department of Reproductive Biology and Obstetrics and Gynecology, University Hospitals Case Medical Center, Cleveland, OH 44106 5034, USA
    Reprod Sci 18:6-19. 2011
    ..Herein, we review current understanding of the PRs expressed in the human pregnancy uterus, the pathways through which they mediate progesterone actions, and their roles in controlling myometrial ..
  14. ncbi The hormonal control of uterine luminal fluid secretion and absorption
    N Salleh
    Division of Reproductive Health, Endocrinology and Development, Guy s Campus, King s College, London, SE1 1UL, UK
    J Membr Biol 206:17-28. 2005
    ..CI(-) channels (ENaC, CFTR) indicated that these channels were subject to tissue-specific regulation within the uterus, but more work is required to determine their role and the factors controlling their abundance and localization in ..
  15. ncbi Fibroblast growth factor-10: a stromal mediator of epithelial function in the ovine uterus
    C Chen
    Center for Animal Biotechnology and Genomics, and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 63:959-66. 2000
    ..endometrial cDNA library to investigate expression and potential paracrine characteristics of FGF-10 in the ovine uterus. The ovine FGF-10 cDNA encodes a protein of 213 amino acids and possesses an unusually long 5' untranslated region ..
  16. ncbi Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus
    Geoffrey A Wood
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Reproduction 133:1035-44. 2007
    ..indicate that measuring P(4) or E(2) levels can predict many concurrent cellular and stromal events in the mouse uterus, suggesting that in naturally cycling mice cellular responses to hormone changes are not delayed, but occur very ..
  17. pmc Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells
    D Randall Armant
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201 1415, USA
    Dev Biol 280:260-80. 2005
    ..on expression of developmental regulatory genes, further differentiation leading to blastocyst implantation in the uterus requires external cues emanating from the microenvironment...
  18. ncbi Phenotypic characterization of endometrial stromal sarcoma of the uterus
    Kazumi Yamada
    Department of Pathology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    Cancer Sci 97:106-12. 2006
    Endometrial stromal sarcoma (ESS) of the uterus is a rare uterine malignancy that has not been characterized in detail...
  19. ncbi Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus
    C A Vercelli
    Laboratory of Physiopathology of Pregnancy and Labour, Centre for Pharmacological and Botanical Studies, Paraguay 2155, Buenos Aires, Argentina
    Reprod Biomed Online 18:824-31. 2009
    ..The uterus contains the highest concentrations of anandamide yet discovered in mammalian tissues and this suggests that it ..
  20. ncbi Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Victoria, Australia
    Nat Med 4:303-8. 1998
    ..A temporal analysis revealed IL-11 expression is maximal in the normal pregnant uterus at the time of decidualization, and in situ hybridization studies showed expression of the IL-11 and the IL-11 ..
  21. ncbi Mechanisms of implantation: strategies for successful pregnancy
    Jeeyeon Cha
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 18:1754-67. 2012
    ..Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization...
  22. pmc Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses
    Wipawee Winuthayanon
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 107:19272-7. 2010
    ....
  23. ncbi Developmental biology of uterine glands
    C A Gray
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 65:1311-23. 2001
    ..during critical organizational periods can alter the functional capacity and embryotrophic potential of the adult uterus reinforces the importance of understanding the developmental biology of uterine glands...
  24. ncbi Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture
    J V Fahey
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire, USA
    Mucosal Immunol 1:317-25. 2008
    ..Further, it suggests that with E(2) regulation, epithelial cells that line the uterine cavity have evolved immunologically to be sensitive to viral and bacterial infections as well as the constraints of procreation...
  25. ncbi Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:602-9. 2009
    ..These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival...
  26. ncbi Successful uterine transplantation in the mouse: pregnancy and post-natal development of offspring
    Randa Racho El-Akouri
    Department of Obstetrics and Gynecology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Hum Reprod 18:2018-23. 2003
    ..Here, the first live-born offspring in any uterine transplantation model is reported...
  27. doi Select nutrients in the ovine uterine lumen. I. Amino acids, glucose, and ions in uterine lumenal flushings of cyclic and pregnant ewes
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Departments of Animal Science and Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 80:86-93. 2009
    ....
  28. ncbi Estrogen replacement regimen and brain infusion of lipopolysaccharide differentially alter steroid receptor expression in the uterus and hypothalamus
    L K Marriott
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA
    Endocrine 32:317-28. 2007
    ..LPS infusion into intact rats suppressed uterine weight, increased ERalpha and decreased HSP90 in the uterus. LPS did not alter uterine weight in ovariectomized rats treated with constant or pulsed estrogen...
  29. ncbi Deciphering the cross-talk of implantation: advances and challenges
    B C Paria
    Department of Pediatrics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7336, USA
    Science 296:2185-8. 2002
    Implantation involves a series of steps leading to an effective reciprocal signaling between the blastocyst and the uterus. Except for a restricted period when ovarian hormones induce a uterine receptive phase, the uterus is an ..
  30. ncbi Osteopontin: roles in implantation and placentation
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 69:1458-71. 2003
    ..molecular mechanisms underlying OPN-mediated adhesion, remodeling, and cell-cell/cell-ECM communication within the uterus and placenta...
  31. doi Regulatory mechanism underlying cyclic changes in mouse uterine bicarbonate secretion: role of estrogen
    Qiong He
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Reproduction 140:903-10. 2010
    ..carbonic anhydrase 2 (CAR2, CA2) and CAR12 (CA12), throughout the estrous cycle, were examined in the mouse uterus by western blot...
  32. doi Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:62-9. 2011
    ....
  33. ncbi Role of secretory protease inhibitor SPINK3 in mouse uterus during early pregnancy
    Wen Chen
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100010, People s Republic of China
    Cell Tissue Res 341:441-51. 2010
    ..the spatiotemporal expression and regulation of serine protease inhibitor Kazal type 3 (SPINK3) in mouse uterus during the estrous cycle and early pregnancy...
  34. pmc Temporal expression pattern of progesterone receptor in the uterine luminal epithelium suggests its requirement during early events of implantation
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 95:2087-93. 2011
    ..To determine the precise timing of progesterone receptor (PR) disappearing from the uterine luminal epithelium (LE) to help understand the significance of the dynamic PR expression in the LE during embryo implantation...
  35. pmc Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Gynecol Oncol 122:424-9. 2011
    ..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes...
  36. doi The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus
    L A Okumu
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Reproduction 140:143-53. 2010
    ..P(4)) supplementation on the expression of oestrogen and P(4) receptors (ESRs and PGRs) in the bovine uterus, heifers (n=263) were randomly assigned to the following treatments: i) cyclic, normal P(4); ii) cyclic, high P(4);..
  37. pmc MGEx-Udb: a mammalian uterus database for expression-based cataloguing of genes across conditions, including endometriosis and cervical cancer
    Akhilesh K Bajpai
    Institute of Bioinformatics and Applied Biotechnology IBAB, Bengaluru Bangalore, Karnataka State, India
    PLoS ONE 7:e36776. 2012
    Gene expression profiling of uterus tissue has been performed in various contexts, but a significant amount of the data remains underutilized as it is not covered by the existing general resources.
  38. doi Heterotopic uterus transplantation in a swine model
    Donna L Avison
    Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Transplantation 88:465-9. 2009
    ..The aim of our study was to examine the feasibility of allogeneic uterine transplantation in a large animal model...
  39. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  40. doi Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:70-8. 2011
    ..These results indicate that L-Arg enhances production of polyamines and NO and activates the MTOR/FRAP1-RPS6K-RPS6 signaling pathway to stimulate proliferation and migration of oTr cells...
  41. doi Review: Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua
    G E Lash
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Placenta 31:S87-92. 2010
    ..Herein we review the functional roles of this important decidual cell type...
  42. ncbi Immune cells in the placental bed
    Judith N Bulmer
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Int J Dev Biol 54:281-94. 2010
    ....
  43. ncbi Unique receptor repertoire in mouse uterine NK cells
    Hakim Yadi
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom
    J Immunol 181:6140-7. 2008
    ..We describe herein two distinct subsets of CD3(-)CD122(+) NK cells in the mouse uterus (comprising decidua and mesometrial lymphoid aggregate of pregnancy) at mid-gestation: a small subset ..
  44. ncbi Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy
    Hicham El Costa
    Institut National de la Santé et de la Recherche Médicale U563 France
    J Immunol 181:3009-17. 2008
    ..These data demonstrate a differential, controlled role of NKp46- and NKp30-activating receptors expressed by dNK that could be critical for the outcome of pregnancy and the killing of uterine cells infected by pathogens...
  45. ncbi PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus
    Janet Alverson
    USDA, ARS, Animal Disease Research Unit, 3003 ADBF, Washington State University, Pullman, WA 99164, USA
    J Gen Virol 87:1035-41. 2006
    ..This indicates that some sharing of fetal blood occurs between placentomes and fetuses residing in the same uterine horn, which can result in PrPSc accumulation in cotyledons with resistant genotypes...
  46. pmc In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus
    Xiaofei Sun
    Division of Reproductive Sciences, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Endocrinology 150:5065-73. 2009
    ..Because of this characteristic, we studied the status of Lgr5 expression in the mouse uterus under various conditions...
  47. pmc Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg
    Vincent Jonchère
    Institut National de la Recherche Agronomique, UR83 Recherches Avicoles, Nouzilly, France
    BMC Genomics 11:57. 2010
    ..The purpose of our study was to identify novel eggshell proteins by examining the transcriptome of the uterus during calcification of the eggshell...
  48. doi Uterine natural killer cells and angiogenesis in recurrent reproductive failure
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, First Floor, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Hum Reprod 24:45-54. 2009
    ..We tested the hypothesis that increased uNK cells in preimplantation endometrium are associated with altered angiogenesis...
  49. ncbi Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice
    H Song
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Mol Endocrinol 14:1147-61. 2000
    ..This suggests that LIF has biphasic effects: first in the preparation of the receptive uterus and subsequently in the attachment reaction...
  50. ncbi Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 74:913-22. 2006
    ..In the kidney and gut, STC regulates calcium and phosphate homeostasis. In the mouse uterus, Stc1 increases in the mesometrial decidua during implantation...
  51. ncbi Mullerian duct anomalies: imaging and clinical issues
    Robert N Troiano
    Department of Radiology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Radiology 233:19-34. 2004
    ..Laparoscopy and hysteroscopy are reserved for women in whom interventional therapy is likely to be undertaken...
  52. doi The immunomodulatory roles of macrophages at the maternal-fetal interface
    Takeshi Nagamatsu
    Division of Perinatal Research, Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, Missouri 65201, USA
    Reprod Sci 17:209-18. 2010
    ..Aberrant activity of uterine macrophages is linked to the pathogenesis of preeclampsia and preterm delivery. Here, we review the immunomodulatory roles of decidual macrophages during pregnancy...
  53. ncbi Implantation mechanisms: insights from the sheep
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics, Animal Science and Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Reproduction 128:657-68. 2004
    ..The embryo enters the uterus on day 4 at the morula stage of development and then develops into a blastocyst by day 6...
  54. ncbi Does radical trachelectomy influence uterine blood supply?
    Petra Klemm
    Department of Gynecology, Friedrich Schiller University, Bachstrasse 18, 07740 Jena, Germany
    Gynecol Oncol 96:283-6. 2005
    ..If pregnancy occurs, premature delivery is a known problem in these patients. We evaluated if uterine blood supply is decreased after radical trachelectomy as one of various possible causes of preterm birth...
  55. ncbi Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus
    M A J Hervé
    INSERM U553, Institut Universitaire d Hematologie, Hôpital Saint Louis Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Endocrinol 188:91-9. 2006
    ..It is currently unknown whether or not the endothelial origin might account for differences in the E(2)-modulation of VEGF receptor expression, particularly in relation to the vascular bed of sex steroid-responsive tissues...
  56. pmc Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach
    Karen Noble
    Department of Physiology, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
    J Physiol 570:29-35. 2006
    The pathways involved in Ca2+ signalling in the uterus remain incompletely understood, impairing our ability to prevent preterm and difficult labours...
  57. ncbi Expression of hepatocyte growth factor and its receptor c-met in the ovine uterus
    C Chen
    Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 62:1844-50. 2000
    ..interactions (EMI) are necessary for epithelial cell proliferation, differentiation, and function in the uterus and are mediated, in part, by paracrine growth factors of stromal origin...
  58. ncbi Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 75:289-96. 2006
    ..and associated extraembryonic membranes) growth and development are primarily regulated by secretions from the uterus. This study investigated the effects of progesterone on preimplantation conceptus development and endometrial ..
  59. ncbi Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide
    B T Alexander
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA
    Hypertension 37:1191-5. 2001
    ....
  60. ncbi Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways
    Fuller W Bazer
    Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Biol 8:179-211. 2008
    ..range from pregnancy recognition signaling in ruminants by IFN tau (IFNT) to effects on cellular functions of the uterus and uterine vasculature...
  61. ncbi Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal
    Sotirios H Saravelos
    Reproductive Medicine and Surgery Unit, University of Sheffield, Sheffield Teaching Hospitals, Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK
    Hum Reprod Update 14:415-29. 2008
    ..The aim of this review is to assess the diagnostic accuracy of different methodologies and estimate the prevalence of congenital uterine anomalies in women with infertility and recurrent miscarriage (RM)...
  62. ncbi Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland
    Michael D Johnson
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Nat Med 9:1081-4. 2003
    ..In the uterus, the increase in wet weight was accompanied by proliferation of the endometrium and induction of progesterone ..
  63. ncbi The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca2+ mobilization in rat uterus
    Yu Cheng Lu
    Department of Pharmacy, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 368:262-9. 2003
    ..on muscular contractile responses and intracellular Ca(2+) mobilization were investigated in the non-pregnant rat uterus. Honokiol and magnolol (1-100 micromol/l) were observed to inhibit spontaneous and uterotonic agonists (carbachol, ..
  64. pmc Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:2676-85. 2010
    ..Additionally, full ER alpha function is needed to mediate other cellular signals of the growth factor for uterine growth...
  65. ncbi Sex steroid hormone receptors in the developing female reproductive tract of laboratory rodents
    Akinobu Okada
    Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tokyo, Japan
    J Toxicol Sci 30:75-89. 2005
    ..Thus, accumulated information on the expression of ER subtypes and isoforms as well as that of progesterone and androgen receptors in laboratory rodents is herein reviewed, in addition to the presentation of our own data...
  66. pmc Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis
    Jeltsje S Cnossen
    Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands
    CMAJ 178:701-11. 2008
    ..We investigated the predictive accuracy of all uterine artery Doppler indices for both conditions in the first and second trimesters...
  67. ncbi Novel actions of estrogen receptor-beta on anxiety-related behaviors
    Trent D Lund
    Department of Biomedical Science, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, Colorado 80523 1670, USA
    Endocrinology 146:797-807. 2005
    ..Tamoxifen blocked the previously identified anxiolytic actions of DPN. Taken together, these findings suggest that the anxiolytic properties of estrogens are ERbeta mediated...
  68. ncbi Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy
    Sandra M Blois
    Charite, Department of Internal Medicine, Biomedizinisches Forschungszentrum, Campus Virchow, Humboldt University of Berlin, 13353 Berlin, Germany
    Biol Reprod 70:1018-23. 2004
    ..The morphology of DC in the pregnant uterus was evaluated by immunohistochemistry. In uterus, the relative number of CD11c+ cells increased from GD 5...
  69. ncbi Differential expression and activation of Stat3 during mouse embryo implantation and decidualization
    Chun Bo Teng
    College of Life Sciences, Northeast Agricultural University, Harbin, China
    Mol Reprod Dev 69:1-10. 2004
    ..This study was to investigate the expression, activation, and regulation of Stat3 in mouse uterus during early pregnancy, pseudopregnancy, delayed implantation, artificial decidualization, and hormonal treatments ..
  70. ncbi Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus
    Hiromichi Matsumoto
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160 7336, USA
    Dev Biol 245:280-90. 2002
    Genes encoding components of the hedgehog signaling pathway are dynamically expressed in the mouse uterus preparing for implantation...
  71. ncbi Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation
    S K Das
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338
    Development 120:1071-83. 1994
    ..These results suggest possible interactions between the uterine HB-EGF and blastocyst EGF-R very early in the process of implantation, earlier than any other embryo-uterine interactions defined to date at the molecular level...
  72. pmc HB-EGF: a unique mediator of embryo-uterine interactions during implantation
    Hyunjung Jade Lim
    Department of Biomedical Science and Technology, Research Center for Drugs, IBST, Konkuk University, 1 Hwayang dong, Kwangjin gu, Seoul 143 701 Korea
    Exp Cell Res 315:619-26. 2009
    ..In this review, we discuss the footprint of HB-EGF as to how it was initially identified as a mediator of implantation and how it initiates embryo-uterine interactions during this process...
  73. ncbi Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract
    C Miller
    Brookdale Center of Developmental and Molecular Biology, One Gustave Levy Place, Box 1126, New York, NY 10029, USA
    Development 125:3201-11. 1998
    ..This process is marked by the emergence of distinct cell types in the oviduct, uterus, cervix and vagina and is dependent upon specific mesenchymal-epithelial interactions as demonstrated by earlier ..
  74. ncbi Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy
    Gendie E Lash
    School of Surgical and Reproductive Sciences, 3rd Floor, William Leech Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Leukoc Biol 80:572-80. 2006
    ..uNK cells appear to be a prominent source of Ang1, Ang2, TGF-beta1, and VEGF-C within the placental bed...
  75. pmc Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation
    Xiaoqin Ye
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 95:2107-13, 2113.e1-4. 2011
    ..To determine factors differentiating LPA3 from other lysophospholipid (LP) receptors for its role in embryo implantation...
  76. pmc Estrogen induces distinct patterns of microRNA expression within the mouse uterus
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, USA
    Reprod Sci 17:987-94. 2010
    Control of estrogenic activity within the uterus is evident as unopposed estrogen action is associated with endometrial pathologies such as endometriosis and endometrial carcinoma...
  77. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
    An effective bidirectional communication between an implantation-competent blastocyst and the receptive uterus is a prerequisite for mammalian reproduction. The blastocyst will implant only when this molecular cross-talk is established...
  78. doi Evaluation of hormonal change, biochemical parameters, and histopathological status of uterus in rats exposed to 50-Hz electromagnetic field
    M Aydin
    Department of Obstetric and Gyneacology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey
    Toxicol Ind Health 25:153-8. 2009
    ..power lines on hormonal status, on progesterone and 17-beta estradiol levels, and on morphology of the uterus and ovaries associated with biochemical parameters of adult Wistar female rats...
  79. ncbi Temporal and spatial regulation of let-7a in the uterus during embryo implantation in the rat
    Hong Fei Xia
    Reproductive and Genetic Center of the National Research Institute for Family Planning, China
    J Reprod Dev 56:73-8. 2010
    ..embryonic implantation requires reciprocal interactions between implantation-competent blastocysts and a receptive uterus. Some microRNAs might play a key role during embryo implantation in the mouse, but the let-7a expression profiles ..
  80. ncbi Reproductive performance of women with müllerian anomalies
    Beth W Rackow
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 19:229-37. 2007
    ..This review discusses current diagnostic techniques for müllerian anomalies, reproductive outcome data, and management options in reproductive-age women...
  81. doi Human NK cells in pregnant uterus: why there?
    Philippe Le Bouteiller
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Am J Reprod Immunol 59:401-6. 2008
    ..Finally, uterine NK cells are likely to be an important component of the local maternal immune response to pathogen infections...
  82. doi SHOX duplications found in some cases with type I Mayer-Rokitansky-Kuster-Hauser syndrome
    Cristina Gervasini
    Medical Genetics, Department of Medicine, Surgery and Dentistry, Universita degli Studi di Milano, Italy
    Genet Med 12:634-40. 2010
    ..The aim of this study was to identify possible recurrent submicroscopic imbalances in a cohort of familial and sporadic cases with Mayer-Rokitansky-Küster-Hauser syndrome...
  83. doi Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-Küster-Hauser syndrome
    Susanne Ledig
    Institut fur Humangenetik, Westfalische Wilhelms Universitat, Munster, Germany
    Fertil Steril 95:1589-94. 2011
    ..To identify genetic causes of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome...
  84. ncbi Human uterine leukocytes and pregnancy
    A Trundley
    Department of Pathology, University of Cambridge, Cambridge, UK
    Tissue Antigens 63:1-12. 2004
    In human pregnancy, the embryo implants into the specialized mucosal wall of the uterus (decidua) and the placenta starts to form...
  85. pmc Changes in apparent diffusion coefficients in the normal uterus during different phases of the menstrual cycle
    A Kido
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto City, Kyoto 606 8507, Japan
    Br J Radiol 83:524-8. 2010
    ..imaging (DWI) was performed with a single-shot echo-planar imaging (EPI) sequence in the midsagittal plane of the uterus using three b-values (b = 0, 500 or 1000 s mm(-2))...
  86. pmc The pathophysiology of endometriosis and adenomyosis: tissue injury and repair
    G Leyendecker
    Kinderwunschzentrum Fertility Center Darmstadt, Bratustrasse 9, 64295, Darmstadt, Germany
    Arch Gynecol Obstet 280:529-38. 2009
    ..In particular, a physiological model is proposed that provides a comprehensive explanation of the local production of estrogen at the level of ectopic endometrial lesions and the endometrium of women affected with the disease...
  87. pmc Primary amenorrhea and absent uterus in the 22q11.2 deletion syndrome
    Usha T Sundaram
    Department of Human Genetics, Virginia Commonwealth University, Medical College of Virginia, Richmond, Virginia, USA
    Am J Med Genet A 143:2016-8. 2007
    ..The phenotype is highly variable and continues to expand. We present two cases of absent uterus and unilateral renal agenesis in females with the 22q11.2 deletion...
  88. ncbi Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy
    S K Das
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    J Mol Endocrinol 22:91-101. 1999
    ..This process can also be induced experimentally (deciduoma) by intraluminal oil infusion in the uterus on day 4 of pseudopregnancy...
  89. pmc IL11 antagonist inhibits uterine stromal differentiation, causing pregnancy failure in mice
    Ellen Menkhorst
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Biol Reprod 80:920-7. 2009
    ..PEGIL11A significantly diminished STAT3 phosphorylation in HES cells in vitro (P < or = 0.05). This study provides valuable information for PEGIL11A that could lead to the development of this protein as a nonhormonal contraceptive...
  90. ncbi Progesterone receptors, oestrogen receptor alpha and glucocorticoid receptors in the bovine intercaruncular uterine wall around parturition
    M Schäubli
    Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Anim Reprod Sci 103:215-27. 2008
    ..This is in strict contrast to the placentome. Comparatively lower local tissue estrogen concentrations around term may be one cause for this difference...
  91. pmc Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infection
    Grant R Yeaman
    Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN, USA
    Immunology 109:137-46. 2003
    ..In this report, we evaluated expression of HIV receptors and coreceptors on epithelial cells in the uterus and found they express several receptors critical for HIV infection including CD4, CXCR4, CCR5 and ..
  92. pmc Quantification of rapid Myosin regulatory light chain phosphorylation using high-throughput in-cell Western assays: comparison to Western immunoblots
    Hector N Aguilar
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e9965. 2010
    ....
  93. pmc Spatiotemporal expression of the serine protease inhibitor, SERPINE2, in the mouse placenta and uterus during the estrous cycle, pregnancy, and lactation
    Schu Rern Chern
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    Reprod Biol Endocrinol 8:127. 2010
    ..In this study, we investigated the expression patterns of SERPINE2 in the mouse placenta and uterus during the estrous cycle, pregnancy, and lactation.
  94. pmc Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    Biserka Mulac-Jericevic
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9744-9. 2003
    ....
  95. ncbi Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats
    Vladimir Kummer
    Veterinary Research Institute, Brno 62132, Czech Republic
    Toxicol Lett 180:212-21. 2008
    ..These effects were likely to be mediated by ERalpha, a major subtype of ER present in uterus, as they were inhibited by treatment with ER antagonist ICI 182,780...
  96. ncbi IL-15 expression at human endometrium and decidua
    K Kitaya
    Department of Obstetrics and Gynecology and Dynamic Pathology Research Institute, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Biol Reprod 63:683-7. 2000
    ..These results suggest that IL-15 expression in human uterine mucosa corresponds to the fluctuation of uterine NK cells and that its production is hormonally controlled, especially by progesterone...
  97. ncbi Tissue kallikrein and bradykinin B2 receptor in human uterus in luteal phase and in early and late gestation
    G Valdes
    Departmentos de Nefrología, Pontificia Universidad Catolica de Chile, Santiago
    Endocrine 16:207-15. 2001
    ..was addressed to evaluate the temporospatial pattern of key components of the kallikreinkinin system in human uterus in luteal phase (n = 7), early pregnancy (isolated spontaneous abortions, n = 11; ectopic pregnancies, n = 9), ..
  98. ncbi Estrogen inhibits calbindin-D28k expression in mouse uterus
    L A Opperman
    Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908
    Endocrinology 130:1728-35. 1992
    ..calbindin-D28k was absent from female rat reproductive tissues, but was abundantly expressed in immature mouse uterus and oviduct...
  99. ncbi Genetic effects of radiotherapy for childhood cancer: gonadal dose reconstruction
    Marilyn Stovall
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 60:542-52. 2004
    ....
  100. ncbi Gene expression changes in the immature rat uterus: effects of uterotrophic and sub-uterotrophic doses of bisphenol A
    J Ashby
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
    Toxicol Sci 82:458-67. 2004
    ..We conclude that BPA does not produce reproducible changes in gene expression in the uterus of immature rats at dose levels that are not also uterotrophic...
  101. ncbi Oxytocin receptor gene expression in rat uterus: regulation by ovarian steroids
    T Murata
    Department of Physiology, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    J Endocrinol 166:45-52. 2000
    ..These results suggest that the decline of progesterone is necessary for the expression of the stimulatory effects of oestrogen on uterine OTR mRNA...

Research Grants79

  1. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2010
    ..estrogen receptor (ER) positive rat mammary model and antagonizes the stimulatory effect of estradiol on the uterus. In contrast to its effects on several breast cancer cell lines, the compound exhibits virtually no growth ..
  2. Neurotoxicity of organophosphorus pesticides in developing guinea pigs
    William R Randall; Fiscal Year: 2010
    ..Although animal studies have confirmed that in-uterus or early postnatal exposure to chlorpyrifos compromises the brain development of rats and mice, the distinct ..
  3. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
    ..A rat model of endometriosis exists (ENDO) that involves autotransplantion on abdominal arteries of pieces of uterus. The transplants form cysts with characteristics similar to the ectopic growths in women...
  4. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen J Berkley; Fiscal Year: 2010
    ..A rat model of endometriosis exists (ENDO) that involves autotransplantion on abdominal arteries of pieces of uterus. The transplants form cysts with characteristics similar to the ectopic growths in women...
  5. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
    ..A rat model of endometriosis exists (ENDO) that involves autotransplantion on abdominal arteries of pieces of uterus. The transplants form cysts with characteristics similar to the ectopic growths in women...
  6. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2010
    ..to increase blood flow to the developing fetus, implantation of the blastocyst (16 cell stage embryo) into the uterus and maternal- fetal tolerance...
  7. Novel Treatment of menopausal hot flushes with an extradiol prodrug
    Istvan Merchenthaler; Fiscal Year: 2009
    ..This conversion is effective in the brain but not in the uterus, breast, or the pituitary gland...
  8. THE ROLE OF THE TYPE 3 DEIODINASE IN DEVELOPMENT
    Donald St Germain; Fiscal Year: 1999
    ..Such exposure to maternal compounds can have either beneficial or detrimental effects. Thus, the function of the uterus and placenta in regulating the flow of substances between the mother and fetus is crucial for fetal development...
  9. THE ROLE OF THE TYPE 3 DEIODINASE IN DEVELOPMENT
    Donald St Germain; Fiscal Year: 2002
    ..Such exposure to maternal compounds can have either beneficial or detrimental effects. Thus, the function of the uterus and placenta in regulating the flow of substances between the mother and fetus is crucial for fetal development...
  10. THE ROLE OF THE TYPE 3 DEIODINASE IN DEVELOPMENT
    Donald St Germain; Fiscal Year: 2001
    ..Such exposure to maternal compounds can have either beneficial or detrimental effects. Thus, the function of the uterus and placenta in regulating the flow of substances between the mother and fetus is crucial for fetal development...
  11. THE ROLE OF THE TYPE 3 DEIODINASE IN DEVELOPMENT
    Donald St Germain; Fiscal Year: 2000
    ..Such exposure to maternal compounds can have either beneficial or detrimental effects. Thus, the function of the uterus and placenta in regulating the flow of substances between the mother and fetus is crucial for fetal development...
  12. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2010
    ..This conversion is effective in the brain but not in the uterus, breast, or the pituitary gland...
  13. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2007
    ..Defined by the presence of endometrial tissue outside of the uterus, these implants respond to the hormonal cues of the menstrual cycle and "bleed" as they would in the uterus...
  14. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    ..Defined by the presence of endometrial tissue outside of the uterus, these implants respond to the hormonal cues of the menstrual cycle and "bleed" as they would in the uterus...
  15. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2006
    ..Defined by the presence of endometrial tissue outside of the uterus, these implants respond to the hormonal cues of the menstrual cycle and "bleed" as they would in the uterus...
  16. IMPROVING COMMUNICATION WITH IVF PATIENTS ABOUT RISKS SUCH AS MULTIPLE BIRTHS
    LINDA FRAZIER; Fiscal Year: 2007
    ..The chance of having a multi-fetal pregnancy is lower when fewer embryos are transferred to the uterus during IVF, but the couple may need to pay for more cycles of treatment to compensate for a lower chance of having ..
  17. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2000
    ..of this application is to elucidate factors governing peripheral sympathetic nerve remodeling in the mature rodent uterus. Our published studies show that sympathetic nerve density of the virgin rat uterus fluctuates throughout the ..
  18. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2000
    ..of this application is to elucidate factors governing peripheral sympathetic nerve remodeling in the mature rodent uterus. Our published studies show that sympathetic nerve density of the virgin rat uterus fluctuates throughout the ..
  19. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2003
    ..of this application is to elucidate factors governing peripheral sympathetic nerve remodeling in the mature rodent uterus. Our published studies show that sympathetic nerve density of the virgin rat uterus fluctuates throughout the ..
  20. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2001
    ..of this application is to elucidate factors governing peripheral sympathetic nerve remodeling in the mature rodent uterus. Our published studies show that sympathetic nerve density of the virgin rat uterus fluctuates throughout the ..
  21. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2002
    ..of this application is to elucidate factors governing peripheral sympathetic nerve remodeling in the mature rodent uterus. Our published studies show that sympathetic nerve density of the virgin rat uterus fluctuates throughout the ..
  22. MD Anderson Cancer Ctr. Gynecology SPORE: Uterine Cancer
    Karen Lu; Fiscal Year: 2007
    ..Tumors arising from the epithelial (endometrium) and smooth muscle (myometrium) compartments of the uterus are important, yet under- funded, causes of morbidity and mortality in the United States...
  23. Molecular Basis of Automaticity in the Myometrium
    Glenna Bett; Fiscal Year: 2007
    ..Spontaneous PTB therefore reflects abnormal timing in the development of the electrical activity of the uterus. Contraction during parturition results from rhythmic electrical activity (pacemaking) intrinsic to myometrium...
  24. Caspase-3 Maintains Uterine Quiescence in a PR and NF-Kappa B Dependent Manner
    Jennifer C Condon; Fiscal Year: 2010
    During the final trimester of pregnancy the uterus undergoes a remarkable transition from a state of relative quiescence to that of an active contractile unit...
  25. Role of the Fetus in the Initiation of Parturition
    CAROLE MENDELSON; Fiscal Year: 2004
    ..mice injected with a histone deacetylase inhibitor near term manifested increased histone acetylation in the uterus and delayed parturition, suggesting the functional importance of the decline in coactivators in the initiation of ..