uterus

Summary

Summary: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.

Top Publications

  1. ncbi Molecular cues to implantation
    S K Dey
    Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA
    Endocr Rev 25:341-73. 2004
  2. ncbi The hormonal control of uterine luminal fluid secretion and absorption
    N Salleh
    Division of Reproductive Health, Endocrinology and Development, Guy s Campus, King s College, London, SE1 1UL, UK
    J Membr Biol 206:17-28. 2005
  3. ncbi The uterine spiral arteries in human pregnancy: facts and controversies
    R Pijnenborg
    Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven, Belgium
    Placenta 27:939-58. 2006
  4. pmc Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    G J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Placenta 30:473-82. 2009
  5. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
  6. ncbi Cre-mediated recombination in cell lineages that express the progesterone receptor
    Selma M Soyal
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 41:58-66. 2005
  7. ncbi Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus
    Mathias Mericskay
    Brookdale Department Molecular, Cell and Developmental Biology, Mount Sinai Medical School, 1 G Levy Place, New York, NY 10029, USA
    Development 131:2061-72. 2004
  8. pmc Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis
    Jeltsje S Cnossen
    Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands
    CMAJ 178:701-11. 2008
  9. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006
  10. ncbi Regulatory T cells mediate maternal tolerance to the fetus
    Varuna R Aluvihare
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Nat Immunol 5:266-71. 2004

Detail Information

Publications351 found, 100 shown here

  1. ncbi Molecular cues to implantation
    S K Dey
    Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA
    Endocr Rev 25:341-73. 2004
    ..implantation is the result of reciprocal interactions between the implantation-competent blastocyst and receptive uterus. Although various cellular aspects and molecular pathways of this dialogue have been identified, a comprehensive ..
  2. ncbi The hormonal control of uterine luminal fluid secretion and absorption
    N Salleh
    Division of Reproductive Health, Endocrinology and Development, Guy s Campus, King s College, London, SE1 1UL, UK
    J Membr Biol 206:17-28. 2005
    ..CI(-) channels (ENaC, CFTR) indicated that these channels were subject to tissue-specific regulation within the uterus, but more work is required to determine their role and the factors controlling their abundance and localization in ..
  3. ncbi The uterine spiral arteries in human pregnancy: facts and controversies
    R Pijnenborg
    Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven, Belgium
    Placenta 27:939-58. 2006
    ..Several features of the human placental bed are mirrored by processes in other species with haemochorial placentation, and studying such models may help to illuminate poorly understood aspects of human placentation...
  4. pmc Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    G J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Placenta 30:473-82. 2009
    ..Dilation has a surprisingly modest impact on total blood flow, and so we suggest the placental pathology associated with deficient conversion is dominated by rheological consequences rather than chronic hypoxia...
  5. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    ..Prenatal male and female reproductive tract development can therefore occur in the absence of estradiol receptor-mediated responsiveness...
  6. ncbi Cre-mediated recombination in cell lineages that express the progesterone receptor
    Selma M Soyal
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 41:58-66. 2005
    ..that Cre excision activity is restricted to cells that express PR in progesterone-responsive tissues such as the uterus, ovary, oviduct, pituitary gland, and mammary gland...
  7. ncbi Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus
    Mathias Mericskay
    Brookdale Department Molecular, Cell and Developmental Biology, Mount Sinai Medical School, 1 G Levy Place, New York, NY 10029, USA
    Development 131:2061-72. 2004
    ..The similarities of the Wnt5a and Wnt7a mutant FRT phenotypes to those described for the Hoxa11 and Hoxa13 mutant FRT phenotypes reveal a mechanism whereby Wnt and Hox genes cooperate to pattern the FRT along the anteroposterior axis...
  8. pmc Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis
    Jeltsje S Cnossen
    Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands
    CMAJ 178:701-11. 2008
    ..We investigated the predictive accuracy of all uterine artery Doppler indices for both conditions in the first and second trimesters...
  9. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006
    ..At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not...
  10. ncbi Regulatory T cells mediate maternal tolerance to the fetus
    Varuna R Aluvihare
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Nat Immunol 5:266-71. 2004
    ..Their absence led to a failure of gestation due to immunological rejection of the fetus...
  11. pmc Natural killer cell-triggered vascular transformation: maternal care before birth?
    Jianhong Zhang
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada
    Cell Mol Immunol 8:1-11. 2011
    ..The uterus of early pregnancy is a non-lymphoid organ enriched in NK cells that are specifically recruited to placental ..
  12. pmc Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle
    I Martin Sheldon
    Institute of Life Science, School of Medicine, Swansea University, Swansea, UK
    Biol Reprod 81:1025-32. 2009
    ..Advances in knowledge about infection and immunity in the female genital tract should be exploited to develop new therapeutics for uterine disease...
  13. ncbi Interstitial Cajal-like cells in human uterus and fallopian tube
    Laurentiu M Popescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, P O Box 35 29, Bucharest 35, Romania
    Ann N Y Acad Sci 1101:139-65. 2007
    ..still a subject of debate, our purpose was to investigate whether ICLC are present in the fallopian tube and/or uterus, and if they share ultrastructural and immunohistochemical (IHC) features and/or functional roles...
  14. ncbi Multiple female reproductive failures in cyclooxygenase 2-deficient mice
    H Lim
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    Cell 91:197-208. 1997
    ....
  15. pmc The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review
    Y Y Chan
    Department of Obstetrics and Gynaecology, Nottingham University Hospitals NHS Trust, Queen s Medical Centre Campus, Derby Road, Nottingham NG7 2UH, UK
    Hum Reprod Update 17:761-71. 2011
    ....
  16. pmc The ageing ovary and uterus: new biological insights
    S M Nelson
    School of Medicine, University of Glasgow, McGregor Building, Western Infirmary, Glasgow, UK
    Hum Reprod Update 19:67-83. 2013
    ..CONCLUSIONS Ageing has incontrovertible detrimental effects on the ovary and the uterus. Our enhanced understanding of ovarian ageing will facilitate early identification of individuals at greatest risk,..
  17. pmc LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    Xiaoqin Ye
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:104-8. 2005
    ..These data identify LPA3 receptor-mediated signalling as having an influence on implantation, and further indicate linkage between LPA signalling and prostaglandin biosynthesis...
  18. pmc Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus
    Cory A Rubel
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030
    Mol Endocrinol 26:1428-42. 2012
    ..To address this issue, we have defined the genome-wide PR cistrome in the murine uterus using chromatin immunoprecipitation (ChIP) followed by massively parallel sequencing (ChIP-seq)...
  19. pmc Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity
    Lenore Pereira
    Departments of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 77:13301-14. 2003
    ..DNA and infected cell proteins were found more often in the decidua than in the placenta, suggesting that the uterus functions as a reservoir for infection...
  20. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
    An effective bidirectional communication between an implantation-competent blastocyst and the receptive uterus is a prerequisite for mammalian reproduction. The blastocyst will implant only when this molecular cross-talk is established...
  21. doi Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 79:1226-36. 2008
    ..IGF1 and IGF2]), their receptors (MET, FGFR2(IIIB), and IGF1R), and IGF binding proteins (IGFBPs) in the ovine uterus. Ewes received daily injections of corn oil vehicle (CO) or 25 mg of P4 in vehicle from 36 h after mating (Day 0) ..
  22. ncbi Neonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouse uterus
    Koji Sato
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Endocr J 56:131-9. 2009
    ..Two loci were cloned, and differential DNA methylation was quantified. Our results indicated that DES altered the expression levels of Dnmts and DNA methylation...
  23. pmc Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 79:376-86. 2008
    Gastrin-releasing peptide (GRP) is abundantly expressed by endometrial glands of the ovine uterus and processed into different bioactive peptides, including GRP1-27, GRP18-27, and a C-terminus, that affect cell proliferation and migration...
  24. doi In vivo analysis of progesterone receptor action in the uterus during embryo implantation
    Heather L Franco
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Cell Dev Biol 19:178-86. 2008
    ..Therefore, understanding the mechanism of PR action in the adult uterus is necessary in order to understand the events of early pregnancy...
  25. ncbi Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age
    Andrew M Sharkey
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 181:39-46. 2008
    ....
  26. doi Progesterone receptors in the human pregnancy uterus: do they hold the key to birth timing?
    Sam Mesiano
    Department of Reproductive Biology and Obstetrics and Gynecology, University Hospitals Case Medical Center, Cleveland, OH 44106 5034, USA
    Reprod Sci 18:6-19. 2011
    ..Herein, we review current understanding of the PRs expressed in the human pregnancy uterus, the pathways through which they mediate progesterone actions, and their roles in controlling myometrial ..
  27. pmc The relationship between uterine pathogen growth density and ovarian function in the postpartum dairy cow
    E J Williams
    Department of Veterinary Clinical Sciences, Royal Veterinary College, North Mymms, Hatfield, UK
    Theriogenology 68:549-59. 2007
    ..Thus, contamination of the uterus with recognized uterine pathogens is associated with ovarian dysfunction during the postpartum period...
  28. ncbi Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland
    Michael D Johnson
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Nat Med 9:1081-4. 2003
    ..In the uterus, the increase in wet weight was accompanied by proliferation of the endometrium and induction of progesterone ..
  29. doi MicroRNA expression and regulation in mouse uterus during embryo implantation
    Shi Jun Hu
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, College of Life Science, Xiamen University, Xiamen 361005, China
    J Biol Chem 283:23473-84. 2008
    ..Many genes have been shown to be significantly changed in mouse uterus during embryo implantation...
  30. ncbi Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium
    P Diel
    , Deutsche Sporthochschule, , Germany
    Hum Reprod 16:997-1006. 2001
    ..The action of genistein on the uterus and vagina of ovariectomized DA/Han rats after 3 day oral administration (25, 50 or 100 mg/kg/BW/d) was compared ..
  31. ncbi Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep
    G A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Biol Reprod 65:820-8. 2001
    ....
  32. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
    ....
  33. ncbi Fibroblast growth factor-10: a stromal mediator of epithelial function in the ovine uterus
    C Chen
    Center for Animal Biotechnology and Genomics, and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 63:959-66. 2000
    ..endometrial cDNA library to investigate expression and potential paracrine characteristics of FGF-10 in the ovine uterus. The ovine FGF-10 cDNA encodes a protein of 213 amino acids and possesses an unusually long 5' untranslated region ..
  34. pmc Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells
    D Randall Armant
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201 1415, USA
    Dev Biol 280:260-80. 2005
    ..on expression of developmental regulatory genes, further differentiation leading to blastocyst implantation in the uterus requires external cues emanating from the microenvironment...
  35. ncbi Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus
    Geoffrey A Wood
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Reproduction 133:1035-44. 2007
    ..indicate that measuring P(4) or E(2) levels can predict many concurrent cellular and stromal events in the mouse uterus, suggesting that in naturally cycling mice cellular responses to hormone changes are not delayed, but occur very ..
  36. ncbi Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    J P Lydon
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 9:2266-78. 1995
    ..Collectively, these results provide direct support for progesterone's role as a pleiotropic coordinator of diverse reproductive events that together ensure species survival...
  37. ncbi Roadmap to embryo implantation: clues from mouse models
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Rev Genet 7:185-99. 2006
    Implantation involves an intricate discourse between the embryo and uterus and is a gateway to further embryonic development...
  38. pmc Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus
    Z Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 97:5936-41. 2000
    Many of the effects of estrogens on the uterus are mediated by ERalpha, the predominant ER in the mature organ...
  39. pmc Estrogen induces distinct patterns of microRNA expression within the mouse uterus
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, USA
    Reprod Sci 17:987-94. 2010
    Control of estrogenic activity within the uterus is evident as unopposed estrogen action is associated with endometrial pathologies such as endometriosis and endometrial carcinoma...
  40. ncbi Insights into the uterus
    Susan Wray
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Exp Physiol 92:621-31. 2007
    ..Study of the physiological mechanisms that produce excitation in the uterus, the subsequent Ca(2)(+) signals and biochemical pathway leading to contraction has underpinned this progress...
  41. pmc A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4
    Michal A Elovitz
    Center for Research and Reproduction in Women s Health, Department of Obstetrics and Gynecology, Biomedical Research Building II III, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Am J Pathol 163:2103-11. 2003
    ..correlating inflammation with preterm birth, the signal transduction pathways responsible for the emptying of the uterus in the setting of intrauterine inflammation has not been elucidated...
  42. ncbi Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Victoria, Australia
    Nat Med 4:303-8. 1998
    ..A temporal analysis revealed IL-11 expression is maximal in the normal pregnant uterus at the time of decidualization, and in situ hybridization studies showed expression of the IL-11 and the IL-11 ..
  43. ncbi Phenotypic characterization of endometrial stromal sarcoma of the uterus
    Kazumi Yamada
    Department of Pathology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    Cancer Sci 97:106-12. 2006
    Endometrial stromal sarcoma (ESS) of the uterus is a rare uterine malignancy that has not been characterized in detail...
  44. ncbi Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus
    C A Vercelli
    Laboratory of Physiopathology of Pregnancy and Labour, Centre for Pharmacological and Botanical Studies, Paraguay 2155, Buenos Aires, Argentina
    Reprod Biomed Online 18:824-31. 2009
    ..The uterus contains the highest concentrations of anandamide yet discovered in mammalian tissues and this suggests that it ..
  45. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
    ..e., the placental bed...
  46. ncbi Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice
    Sarah A Robertson
    Research Centre for Reproductive Health and Department of Obstetrics and Gynecology, University of Adelaide, Adelaide, SA 5005, Australia
    J Immunol 177:4888-96. 2006
    IL-10 is highly expressed in the uterus and placenta and is implicated in controlling inflammation-induced pathologies of pregnancy...
  47. pmc Specific strains of Escherichia coli are pathogenic for the endometrium of cattle and cause pelvic inflammatory disease in cattle and mice
    I Martin Sheldon
    Institute of Life Science, School of Medicine, Swansea University, Singleton Park, Swansea, United Kingdom
    PLoS ONE 5:e9192. 2010
    ..We tested the expectation that multiple genetically diverse E. coli from the environment opportunistically contaminate the uterine lumen after parturition to establish PID...
  48. pmc Isoflavone genistein induces fluid secretion and morphological changes in the uteri of post-pubertal rats
    Naguib Salleh
    Department of Physiology, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia
    Int J Med Sci 10:665-75. 2013
    ..following high genistein intake could be related to alteration in the normal fluid volume and morphology of the uterus in adult female...
  49. pmc Interferon-ε protects the female reproductive tract from viral and bacterial infection
    Ka Yee Fung
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Science 339:1088-92. 2013
    ..Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden...
  50. pmc Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg
    Vincent Jonchère
    Institut National de la Recherche Agronomique, UR83 Recherches Avicoles, Nouzilly, France
    BMC Genomics 11:57. 2010
    ..The purpose of our study was to identify novel eggshell proteins by examining the transcriptome of the uterus during calcification of the eggshell...
  51. pmc Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation
    J G Cheng
    Cancer and Developmental Biology Laboratory, Division of Basic Science, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 98:8680-5. 2001
    Leukemia inhibitory factor (LIF) expression in the uterus is essential for embryo implantation in mice...
  52. doi Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization
    Xiao Huan Liang
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Science, Xiamen University, Xiamen 361005, China
    Endocrinology 151:5007-16. 2010
    Embryo implantation is an intricate interaction between receptive uterus and active blastocyst. The mechanism underlying embryo implantation is still unknown...
  53. doi Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-Küster-Hauser syndrome
    Susanne Ledig
    Institut fur Humangenetik, Westfalische Wilhelms Universitat, Munster, Germany
    Fertil Steril 95:1589-94. 2011
    ..To identify genetic causes of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome...
  54. pmc De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis
    Amrita Das
    Center for Research in Reproduction and Infertility, and Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 106:12542-7. 2009
    ..Collectively, these studies identified the decidual uterus as a novel site of E biosynthesis and uncovered E-regulated maternal signaling pathways that critically control ..
  55. ncbi Estrogen supplementation modulates effects of the endocrine disrupting pollutant PCB126 in rat bone and uterus: diverging effects in ovariectomized and intact animals
    P Monica Lind
    Karolinska Institutet, Institute of Environmental Medicine, P O Box 210, Nobels vag 13, plan 3, S 17177 Stockholm, Sweden
    Toxicology 199:129-36. 2004
    ..For this purpose two highly estrogen-dependent tissues, bone and uterus, were studied...
  56. doi The unique properties of uterine NK cells
    Irit Manaster
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School, IMRIC, Jerusalem, Israel
    Am J Reprod Immunol 63:434-44. 2010
    ..We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidua during pregnancy...
  57. pmc The CCAAT/enhancer binding protein beta is a critical regulator of steroid-induced mitotic expansion of uterine stromal cells during decidualization
    Wei Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Endocrinology 151:3929-40. 2010
    ..We previously identified CCAAT/enhancer binding protein beta (C/EBPbeta) as a target of steroid regulation in the uterus. Uteri of mice lacking C/EBPbeta failed to undergo decidualization...
  58. pmc Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Exp Med 187:217-23. 1998
    ..Thus, uNK cells appear to have critical functions in pregnancy that promote decidual health, the appropriate vascularization of implantation sites, and placental size...
  59. doi Reproductive outcomes in women with congenital uterine anomalies: a systematic review
    Y Y Chan
    Department of Obstetrics and Gynaecology, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham, UK
    Ultrasound Obstet Gynecol 38:371-82. 2011
    ..We conducted a systematic review to evaluate the association between different types of congenital uterine anomaly and various reproductive outcomes...
  60. pmc Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors
    B C Paria
    Department of Pediatrics, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City, KS 66160 7338, USA
    Proc Natl Acad Sci U S A 98:1047-52. 2001
    The implantation of a blastocyst into a receptive uterus is associated with a series of events, namely the attachment reaction followed by decidualization of the stroma...
  61. ncbi Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:45-55. 2006
    ..In the uterus, PR activity in the stroma compartment of both wild-type and SRC-3(-/-) mice was induced by estrogen + ..
  62. ncbi WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report
    A Biason-Lauber
    University Children s Hospital, Zurich, Switzerland
    Hum Reprod 22:224-9. 2007
    ..In fact, it appears that at least in this limited casuistic small group of patients, the absence of a uterus (and not other Müllerian abnormalities) and the androgen excess are the pathognomonic signs of WNT4 defects, ..
  63. ncbi Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus
    S K Das
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Mol Endocrinol 9:691-705. 1995
    A synchrony between the activated state of the blastocyst and differentiation of the uterus to the receptive state is essential to the process of implantation. This process is directed by progesterone (P4) and estrogen...
  64. doi Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review
    A W Tang
    Department for Women s and Children s Health, Institute of Translational Medicine, University of Liverpool, Liverpool L8 7SS, UK
    Hum Reprod 26:1971-80. 2011
    ..We systematically reviewed the literature to assess whether numbers or activity of pNK or uNK cells predicted subsequent pregnancy and outcome...
  65. ncbi Uterine temporal response to acute exposure to 17alpha-ethinyl estradiol in the immature rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
    Toxicol Sci 97:467-90. 2007
    The rat uterus responds to acute estrogen treatment with a series of well-characterized physiological responses; however, the gene expression changes required to elicit these responses have not been fully characterized...
  66. doi The immunomodulatory roles of macrophages at the maternal-fetal interface
    Takeshi Nagamatsu
    Division of Perinatal Research, Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, Missouri 65201, USA
    Reprod Sci 17:209-18. 2010
    ..Aberrant activity of uterine macrophages is linked to the pathogenesis of preeclampsia and preterm delivery. Here, we review the immunomodulatory roles of decidual macrophages during pregnancy...
  67. ncbi Female reproductive tract fluids: composition, mechanism of formation and potential role in the developmental origins of health and disease
    Henry J Leese
    Department of Biology, University of York, P O Box 373, York, YO10 5YW, UK
    Reprod Fertil Dev 20:1-8. 2008
    The oviduct and uterus provide the environments for the earliest stages of mammalian embryo development...
  68. doi The electrical activities of the uterus during pregnancy
    Wim J E P Lammers
    Department of Physiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Reprod Sci 20:182-9. 2013
    ..of knowledge of cardiac and of gastrointestinal electrophysiology, our current knowledge of the physiology of the uterus during pregnancy is still very rudimentary...
  69. doi Mechanisms of implantation: strategies for successful pregnancy
    Jeeyeon Cha
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 18:1754-67. 2012
    ..Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization...
  70. pmc Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses
    Wipawee Winuthayanon
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 107:19272-7. 2010
    ....
  71. doi Select nutrients in the ovine uterine lumen. I. Amino acids, glucose, and ions in uterine lumenal flushings of cyclic and pregnant ewes
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Departments of Animal Science and Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 80:86-93. 2009
    ....
  72. pmc Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Gynecol Oncol 122:424-9. 2011
    ..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes...
  73. ncbi Successful uterine transplantation in the mouse: pregnancy and post-natal development of offspring
    Randa Racho El-Akouri
    Department of Obstetrics and Gynecology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Hum Reprod 18:2018-23. 2003
    ..Here, the first live-born offspring in any uterine transplantation model is reported...
  74. doi The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus
    L A Okumu
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Reproduction 140:143-53. 2010
    ..P(4)) supplementation on the expression of oestrogen and P(4) receptors (ESRs and PGRs) in the bovine uterus, heifers (n=263) were randomly assigned to the following treatments: i) cyclic, normal P(4); ii) cyclic, high P(4);..
  75. pmc MGEx-Udb: a mammalian uterus database for expression-based cataloguing of genes across conditions, including endometriosis and cervical cancer
    Akhilesh K Bajpai
    Institute of Bioinformatics and Applied Biotechnology IBAB, Bengaluru Bangalore, Karnataka State, India
    PLoS ONE 7:e36776. 2012
    Gene expression profiling of uterus tissue has been performed in various contexts, but a significant amount of the data remains underutilized as it is not covered by the existing general resources.
  76. doi Regulatory mechanism underlying cyclic changes in mouse uterine bicarbonate secretion: role of estrogen
    Qiong He
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Reproduction 140:903-10. 2010
    ..carbonic anhydrase 2 (CAR2, CA2) and CAR12 (CA12), throughout the estrous cycle, were examined in the mouse uterus by western blot...
  77. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  78. doi Heterotopic uterus transplantation in a swine model
    Donna L Avison
    Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Transplantation 88:465-9. 2009
    ..The aim of our study was to examine the feasibility of allogeneic uterine transplantation in a large animal model...
  79. ncbi Estrogen replacement regimen and brain infusion of lipopolysaccharide differentially alter steroid receptor expression in the uterus and hypothalamus
    L K Marriott
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA
    Endocrine 32:317-28. 2007
    ..LPS infusion into intact rats suppressed uterine weight, increased ERalpha and decreased HSP90 in the uterus. LPS did not alter uterine weight in ovariectomized rats treated with constant or pulsed estrogen...
  80. doi Role of secretory protease inhibitor SPINK3 in mouse uterus during early pregnancy
    Wen Chen
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100010, People s Republic of China
    Cell Tissue Res 341:441-51. 2010
    ..the spatiotemporal expression and regulation of serine protease inhibitor Kazal type 3 (SPINK3) in mouse uterus during the estrous cycle and early pregnancy...
  81. doi Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture
    J V Fahey
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire, USA
    Mucosal Immunol 1:317-25. 2008
    ..Further, it suggests that with E(2) regulation, epithelial cells that line the uterine cavity have evolved immunologically to be sensitive to viral and bacterial infections as well as the constraints of procreation...
  82. ncbi Developmental biology of uterine glands
    C A Gray
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 65:1311-23. 2001
    ..during critical organizational periods can alter the functional capacity and embryotrophic potential of the adult uterus reinforces the importance of understanding the developmental biology of uterine glands...
  83. doi Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:602-9. 2009
    ..These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival...
  84. doi Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:70-8. 2011
    ..These results indicate that L-Arg enhances production of polyamines and NO and activates the MTOR/FRAP1-RPS6K-RPS6 signaling pathway to stimulate proliferation and migration of oTr cells...
  85. pmc Temporal expression pattern of progesterone receptor in the uterine luminal epithelium suggests its requirement during early events of implantation
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 95:2087-93. 2011
    ..To determine the precise timing of progesterone receptor (PR) disappearing from the uterine luminal epithelium (LE) to help understand the significance of the dynamic PR expression in the LE during embryo implantation...
  86. doi Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:62-9. 2011
    ....
  87. ncbi Deciphering the cross-talk of implantation: advances and challenges
    B C Paria
    Department of Pediatrics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7336, USA
    Science 296:2185-8. 2002
    Implantation involves a series of steps leading to an effective reciprocal signaling between the blastocyst and the uterus. Except for a restricted period when ovarian hormones induce a uterine receptive phase, the uterus is an ..
  88. doi Review: Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua
    G E Lash
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Placenta 31:S87-92. 2010
    ..Herein we review the functional roles of this important decidual cell type...
  89. ncbi Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy
    Hicham El Costa
    Institut National de la Santé et de la Recherche Médicale U563 France
    J Immunol 181:3009-17. 2008
    ..These data demonstrate a differential, controlled role of NKp46- and NKp30-activating receptors expressed by dNK that could be critical for the outcome of pregnancy and the killing of uterine cells infected by pathogens...
  90. doi Immune cells in the placental bed
    Judith N Bulmer
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Int J Dev Biol 54:281-94. 2010
    ....
  91. ncbi Unique receptor repertoire in mouse uterine NK cells
    Hakim Yadi
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom
    J Immunol 181:6140-7. 2008
    ..We describe herein two distinct subsets of CD3(-)CD122(+) NK cells in the mouse uterus (comprising decidua and mesometrial lymphoid aggregate of pregnancy) at mid-gestation: a small subset ..
  92. pmc In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus
    Xiaofei Sun
    Division of Reproductive Sciences, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Endocrinology 150:5065-73. 2009
    ..Because of this characteristic, we studied the status of Lgr5 expression in the mouse uterus under various conditions...
  93. ncbi PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus
    Janet Alverson
    USDA, ARS, Animal Disease Research Unit, 3003 ADBF, Washington State University, Pullman, WA 99164, USA
    J Gen Virol 87:1035-41. 2006
    ..This indicates that some sharing of fetal blood occurs between placentomes and fetuses residing in the same uterine horn, which can result in PrPSc accumulation in cotyledons with resistant genotypes...
  94. pmc The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network
    Margeaux Wetendorf
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 357:108-18. 2012
    ..Successful pregnancy is dependent on a healthy uterus that is fit to receive and support a fertilized embryo...
  95. ncbi Osteopontin: roles in implantation and placentation
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 69:1458-71. 2003
    ..molecular mechanisms underlying OPN-mediated adhesion, remodeling, and cell-cell/cell-ECM communication within the uterus and placenta...
  96. pmc Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst
    Kartik Shankar
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 152:4158-70. 2011
    ..We conducted global transcriptomic profiling in the uterus and periimplantation blastocyst, gene/protein expression analyses of inflammatory pathways in conjunction with ..
  97. ncbi Uterine artery Doppler flow and uteroplacental vascular pathology in normal pregnancies and pregnancies complicated by pre-eclampsia and small for gestational age fetuses
    M W Aardema
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Perinatal Medicine, University Hospital, Groningen, The Netherlands
    Placenta 22:405-11. 2001
    ..This variation may be partly due to sampling error, as a typical biopsy contains only one or two spiral arteries. We hypothesize that additional factors might be necessary to induce the clinical syndrome of pre-eclampsia...
  98. doi Uterine natural killer cells and angiogenesis in recurrent reproductive failure
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, First Floor, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Hum Reprod 24:45-54. 2009
    ..We tested the hypothesis that increased uNK cells in preimplantation endometrium are associated with altered angiogenesis...
  99. ncbi Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice
    H Song
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Mol Endocrinol 14:1147-61. 2000
    ..This suggests that LIF has biphasic effects: first in the preparation of the receptive uterus and subsequently in the attachment reaction...
  100. ncbi Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus
    M A J Hervé
    INSERM U553, Institut Universitaire d Hematologie, Hôpital Saint Louis Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Endocrinol 188:91-9. 2006
    ..It is currently unknown whether or not the endothelial origin might account for differences in the E(2)-modulation of VEGF receptor expression, particularly in relation to the vascular bed of sex steroid-responsive tissues...
  101. ncbi Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 74:913-22. 2006
    ..In the kidney and gut, STC regulates calcium and phosphate homeostasis. In the mouse uterus, Stc1 increases in the mesometrial decidua during implantation...

Research Grants73

  1. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..estrogen receptor (ER) positive rat mammary model and antagonizes the stimulatory effect of estradiol on the uterus. In contrast to its effects on several breast cancer cell lines, the compound exhibits virtually no growth ..
  2. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..Ischemia is one of the leading causes of smooth muscle spasm in the stomach, intestine, uterus, and bronchioles...
  3. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..diabetes, obesity, osteoporosis, polycystic ovary syndrome and neoplasms of the colon, breast, ovary, and uterus. Considering the importance sex steroids in health and disease, we must have a better understanding of the ..
  4. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..Furthermore, unlike estradiol, the plant extracts did not increase the weight of the uterus. These results indicate that the ERa activity of the plant extracts do not lead to cell proliferation...
  5. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..The epigenetic effects of exposure to EDCs (e.g., the pesticide methoxychlor, MXC) on other organs, including the uterus and mammary gland, have been studied...
  6. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    ..In addition, poor maternal blood supply to the uterus, maternal stress and other complications will also induce fetal nutrient deficiency...
  7. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ....
  8. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..I will also test the hypothesis that enhanced integrin-ERK activation in the uterus contributes to preterm labor...
  9. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..I will also test the hypothesis that enhanced integrin-ERK activation in the uterus contributes to preterm labor...
  10. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..estrogens because of their potential side effects, the most critical of which are the effects of estrogen on the uterus and the breast...
  11. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..This conversion is effective in the brain but not in the uterus, breast, or the pituitary gland...
  12. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..to increase blood flow to the developing fetus, implantation of the blastocyst (16 cell stage embryo) into the uterus and maternal-fetal tolerance...
  13. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..hormonal system - the renin angiotensin system in multiple tissues including the brain, heart, kidney and uterus/placenta...
  14. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013
    ..tumor, and provide additional tools when traditional imaging strategies miss or confuse lesions of the breast and uterus. Unlike fluorescence and optical microscopy, MRI is not limited by depth or transparency of the specimen...
  15. Chemoprevention of Tamoxifen-induced Endometrial cancer by black cohosh and red c
    BIRGIT MARIA DIETZ; Fiscal Year: 2010
    ..of these botanicals to induce the detoxification enzymes, quinone reductase and glutathione-S-transferase, in the uterus and liver of adult rats...
  16. Mechanisms of vascular-specific gene regulation by estrogen
    Gavin R Schnitzler; Fiscal Year: 2013
    ..to correlate and compare temporal changes in ER[unreadable] recruitment and gene expression in mouse aorta, uterus and liver...
  17. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2013
    ..studies by analyzing the unique and redundant roles of the type 1 and type 2 receptors in BMP signaling in the uterus and identifying new agents for inhibiting and/or mimicking the functions of BMPs, activins and myostatin in ..
  18. Fetal HCMV Infection: Role of the Human Placenta
    LENORE PALMA PEREIRA; Fiscal Year: 2013
    ..of growth factors and cytokines secreted from placental CTB (fetal) and decidual cells (maternal) in the pregnant uterus. The specific aims are as follows. Aim 1...
  19. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2013
    ..to increase blood flow to the developing fetus, implantation of the blastocyst (16 cell stage embryo) into the uterus and maternal- fetal tolerance...
  20. Steroid regulation of glucose utilization during early pregnancy.
    ANTONINA I FROLOVA; Fiscal Year: 2010
    ..In the uterus, estradiol differentially modulates glucose uptake by regulating the expression of specific glucose transporters ..
  21. ELECTROPHYSIOLOGICAL CORRELATES OF VASOPRESSIN RELEASE
    William E Armstrong; Fiscal Year: 2011
    ..into the blood stream for effects at distal organs, such as kidney, vascular smooth muscle, mammary gland and uterus. Release is a function of the frequency and pattern of the action potential trains of these neurons when excited...
  22. Serine Protease Corin in Pregnancy-induced Hypertension
    Qingyu Wu; Fiscal Year: 2013
    ..Unexpectedly, we found high levels of corin expression in the pregnant uterus and placenta in mice, suggesting a potential role of corin in pregnancy...
  23. Mechanism of Gene Repression in the Kidney
    Sanjeevkumar R Patel; Fiscal Year: 2013
    ..role for the Pax2 gene in the development of epithelial structures, including the kidneys, ureters, female uterus, and male ejaculatory ducts...
  24. Neurotoxicity of organophosphorus pesticides in developing guinea pigs
    William Randall; Fiscal Year: 2013
    ..Although animal studies have confirmed that in-uterus or early postnatal exposure to chlorpyrifos compromises the brain development of rats and mice, the distinct ..
  25. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2012
    ..In mouse uterus, as well as in human endometrial cancer and breast cancer cells, estrogen stimulation results in cascades of gene ..
  26. INITIATION OF HUMAN LABOR: PREVENTION OF PREMATURITY
    Carole R Mendelson; Fiscal Year: 2013
    ..factor MiTF-CX, and (4) to test the hypothesis that physiological and pathological inflammatory responses in the uterus and cervix during pregnancy and parturition share a common set of molecular events that play crucial roles in the ..
  27. Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
    Teresa K Woodruff; Fiscal Year: 2013
    ..There are five main organs in the female reproductive tract-the ovary, fallopian tubes, uterus, cervix and vagina...
  28. BISPHENOL A LEVELS and ENDOMETRIOSIS RISK IN REPRODUCTIVE-AGE WOMEN
    Victoria L Holt; Fiscal Year: 2012
    ..Endometriosis, the presence of endometrial tissue outside the uterus, affects approximately 8-10% of women of reproductive age in the U.S...
  29. Uterine-specific genetic modification and lymphangioleiomyomatosis
    JOSE M TEIXEIRA; Fiscal Year: 2012
    ..The Mullerian duct-derived internal female reproductive tract organs (uterus, oviduct, cervix, and cranial portion of the vagina) are the only structures from the bipotential mammalian embryo ..
  30. Mechanism of DLC1-mediated tumor suppression
    Su Hao Lo; Fiscal Year: 2013
    ..or DNA methylation is associated with a variety of cancer types including prostate, lung, breast, kidney, colon, uterus, ovary, and stomach...
  31. Immune Gene Regulation in Human Trophoblast Cells
    Shawn P Murphy; Fiscal Year: 2012
    ..Importantly, IFN-3 is present in the uterus during normal pregnancy...
  32. Antiprogestin therapy for ovarian cancer
    CARLOS MARCELO TELLERIA; Fiscal Year: 2012
    ..abnormal growths have already progressed beyond the confines of the ovaries and into the nearby fallopian tubes, uterus, and various other sites within the peritoneal cavity...
  33. Molecular Analysis of Uterine Receptivity
    FRANCESCO JOHN DEMAYO; Fiscal Year: 2013
    ..objective of this proposal is to define the essential molecular mechanisms that underlie the preparation of the uterus to support embryo implantation...
  34. Role of estrogen receptor in endometrial cancer initiation and progression
    Sanaz Memarzadeh; Fiscal Year: 2013
    ..2) What are the ER mediated mechanisms that can lead to the formation of endometrial cancer? (3) Where in the uterus are estrogenic effects mediated, endometrial epithelium and/or stroma? A major limitation in studying endometrial ..
  35. The effects of stress on the pathophysiology of endometriosis
    MARIELLY CUEVAS; Fiscal Year: 2010
    ..occurs when endometrial tissue that is shed during menses is able to attach, invade and grow outside the uterus. Ectopic endometrial growth usually occurs within the pelvic region on the ovaries and other peritoneal organs, ..
  36. Induction of uterine vascular remodeling by myometrial stretch
    George J Osol; Fiscal Year: 2013
    ..This R21 project is inspired by our recent discovery that physical distension of the rat uterus in the nonpregnant state leads to significant expansive growth of the mesometrial arteries and veins similar to ..
  37. Extranuclear estrogen receptor actions on endometrial cancer cell proliferation
    Twila A Jackson; Fiscal Year: 2012
    ..and controls critical cellular processes such as proliferation and differentiation in many tissues including uterus, breast, liver, brain...
  38. Atrogin-1 and Muscle Protein Balance
    Stewart H Lecker; Fiscal Year: 2010
    ..role in the skeletal muscle toxicity of HMG CoA reductase inhibitors (statins) and in the normal involution of the uterus following delivery...
  39. C60, MWCNTs and the Influence on Cardiovascular, Reproductive, and Developmental
    Timothy R Fennell; Fiscal Year: 2013
    ..rodent (and neonate), and to determine how exposure affects the vascular reactivity ofthe heart, lung, and uterus. Further, we propose to measure markers of inflammation (cytokines), oxidative stress (8- hydroxydeoxyguanosine), ..
  40. Design & Synthesis of Novel CNS-Active Oxytocin and Vasopressin Receptor Ligands
    Edward Roberts; Fiscal Year: 2010
    ..Oxytocin peptide is responsible for labor and lactation control in the uterus and mammary glands respectively...
  41. Hamster: a unique model for studying implantation
    BIBHASH CHANDRA PARIA; Fiscal Year: 2013
    ..several biologically and clinically important aspects of implantation: 1) muscular tone of the receptive uterus, 2) blastocyst-uterine cross talk prior to implantation, 3) trophoblast attachment, outgrowth and invasion, and 4) ..
  42. VERGFR-1 in the Uterine Circulation During Pregnancy
    George J Osol; Fiscal Year: 2011
    ..PlGF, VEGF) and a surgical uterine horn ligation model, in which implantation is restricted to one side of the uterus, will be used for these studies and combined with in vitro assessment of structural changes in arteries and veins, ..
  43. The Function of the Mia3 Gene in Murine Placentation
    Ann E Sutherland; Fiscal Year: 2012
    ..The structure of the placenta is complex, consisting of regions of invasion and anchorage within the uterus as well as a region of vascular exchange, all of which have trophoblast cells as their primary structural and ..
  44. Analysis of the role of the SWI/SNF complex in tumor suppression
    Charles Roberts; Fiscal Year: 2013
    ..at high frequency in a variety of human cancers including those of ovary, breast, kidney, lung, pancreas, uterus, bladder, stomach, colon, liver [and skin]...
  45. Nitric oxide regulation of CD55 and infection
    Chandrasekhar Yallampalli; Fiscal Year: 2013
    ..Further, NO modulates CD55 expression in rat uterus similar to the cell lines. These hypotheses will be tested in three specific aims. AIM 1...
  46. CK2-dependent phosphorylation of Progesterone Receptors mediates proliferative si
    Christy Hagan; Fiscal Year: 2013
    ..How are isoform-specific mitogenic (PR-B in the breast) and inhibitory/differentiative (PR-A in the uterus) effects achieved? PR-A and PR-B are most often co-expressed in the same tissues, and cells that express only a ..
  47. Steroid Hormone Regulation of Uterine Function and Dysfunction
    Jae Wook Jeong; Fiscal Year: 2012
    ..Using high density DNA microarray analysis, we have identified Mig-6 in the uterus as a target of SRC-1 and PR...
  48. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2010
    ..More than 50% of normally conceived pregnancies fail in the period at about the time the embryo attaches to the uterus and begins to implant...
  49. Molecular mechanism of LPA3-mediated uterine receptivity
    Xiaoqin Ye; Fiscal Year: 2013
    ..The molecular mechanism of how a uterus transforms into a receptive state for embryo implantation is not well understood...
  50. Functional and molecular identification of TREK-1 channel in myometrium in relati
    Sang Don Koh; Fiscal Year: 2010
    ..activated by stretch of the plasma membrane may contribute an important component of the myogenic response in the uterus. Several K+ channels participate in the regulation of resting membrane potential and repolarization of action ..
  51. Modulation of the Receptive Endometrium by CG
    Asgerally T Fazleabas; Fiscal Year: 2013
    ..in a genetically modified mouse model that failed to decidualize when Notch1 was specifically ablated in the uterus. Based on these studies three specific aims are proposed in this application to elucidate the role of Notch1 in ..
  52. Identification of maternal and fetal genetic factors in preterm birth
    Jeffrey C Murray; Fiscal Year: 2010
    ..factors in prematurity is that the risk case is not explicitly defined as it might be either the mother and her uterus, the infant/placental unit, or the two together...
  53. FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTION
    Gordon C Douglas; Fiscal Year: 2013
    In human and non-human primates, trophoblasts invade the uterus and uterine vasculature. Endovascular trophoblasts migrate against the flow of blood, reaching uterine spiral arteries which they remodel...
  54. Identification of novel phytoprogestins from hops and red clover
    Joanna E Burdette; Fiscal Year: 2011
    ..To eliminate this risk in women with a uterus, the addition of progesterone to HRT in the form of combined estrogen/progesterone replacement has been ..
  55. Caspase-3 Maintains Uterine Quiescence in a PR and NF-Kappa B Dependent Manner
    Jennifer C Condon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During the final trimester of pregnancy the uterus undergoes a remarkable transition from a state of relative quiescence to that of an active contractile unit...
  56. FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    Lawrence S Prince; Fiscal Year: 2012
    ..Prenatal exposure to chorioamnionitis (inflammation of the maternal membranes, placenta, and uterus) increases the risk of bronchopulmonary dysplasia in preterm infants...
  57. Role of misoprostol in Clostridium sordellii endometritis in a rodent model
    David M Aronoff; Fiscal Year: 2012
    ..Beginning in 2001, several otherwise healthy women developed (and died from) overwhelming infections of the uterus caused by the bacterium Clostridium sordellii, within days of using the oral MFP/vaginal misoprostol regimen...
  58. Multisensory foundations of speech perception in infancy
    Janet F Werker; Fiscal Year: 2013
    ..Heard speech, both of the maternal voice via bone conduction and of external (filtered) speech through the uterus, is organized in part by this somatosensory/motor foundation...
  59. MOLECULAR AND METABOLIC ASPECTS OF IMPLANTATION
    Kelle H Moley; Fiscal Year: 2013
    ..as a result of our studies examining the effects of high estrogen/androgen levels on glucose utilization in the uterus, new therapeutic interventions for implantation failure in patients with PCOS, and these endocrine disorders, may ..
  60. Genetic Epidemiology of Pelvic Organ Prolapse
    Jennifer Marie Wu; Fiscal Year: 2010
    ..End-stage disease is characterized by complete protrusion of the uterus or vagina external to the body, resulting in a marked reduction in quality of life due to pelvic discomfort and ..
  61. TPR Proteins in Steroid Receptor Signaling & Physiology
    EDWIN SANCHEZ; Fiscal Year: 2009
    ..Further characterization has revealed the infertility to result from inactivity in the uterus by the PR-A progesterone receptor isoform, leading to a failure of implantation...
  62. Epigenetic regulation of decidual inflammation
    Adrian Erlebacher; Fiscal Year: 2013
    ..on the molecular pathways that control decidual inflammation and leukocyte trafficking in the pregnant mouse uterus. We have found that the differentiation of endometrial stromal cells (ESCs) into decidual stromal cells (DSCs) ..
  63. THE EFFECTS OF COCAINE ON FETAL OXYGENATION
    James Woods; Fiscal Year: 1993
    ..2) The pregnant uterus, when compared with a parallel vascular bed (hind limb) is a primary target organ for cocaine action...
  64. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2010
    ..This model is very similar to the rat endometriosis model where a section of uterus is transplanted to a intraperitoneal site...
  65. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    ..Defined by the presence of endometrial tissue outside of the uterus, these implants respond to the hormonal cues of the menstrual cycle and "bleed" as they would in the uterus...
  66. PAF AND PRE-IMPLANTATION/IMPLANTATION PHENOMENA
    Michael Harper; Fiscal Year: 1991
    ..be intimately involved in several events in the pre-implantation stage of pregnancy and in the preparation of the uterus for implantation...
  67. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 1993
    Implantation signals a massive cellular response in the uterus. Among the major cell types that expand in response to pregnancy are macrophages, cells with both primitive and highly sophisticated functions...
  68. Ontogeny of CRLR and RAMPs in Myometrium
    Chandrasekhar Yallampalli; Fiscal Year: 2002
    ..In the absence or imbalance of these molecules within the uterus, fetus will be delivered prematurely...
  69. NOVEL ROLE AND REGULATION OF UTERINE TIMPS
    Warren Nothnick; Fiscal Year: 2000
    ..of steroids and TIMP-1 on the spatiotemporal relationship among the steroid receptors and TIMP-1 and TIMP-3 in the uterus. In Specific Aim 2, the mechanisms for steroidal regulation of uterine TIMP-1 and TIMP-3, as well as the ..
  70. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2003
    ..of this application is to elucidate factors governing peripheral sympathetic nerve remodeling in the mature rodent uterus. Our published studies show that sympathetic nerve density of the virgin rat uterus fluctuates throughout the ..
  71. MOLECULAR ENDOCRINOLOGY OF THE UTERUS
    Elizabeth Stewart; Fiscal Year: 2001
    ..The hypothesis is that a unique receptor transduces the actions of hCG and/or alpha-subunit in the human uterus. The aim of this proposal is to characterize, using the techniques of molecular biology and molecular genetics, ..
  72. ROLE OF ADENYL PURINES IN MYOMETRIAL FUNCTION
    IAIN BUXTON; Fiscal Year: 1993
    This project proposes that adenyl purines, compounds known to cause contraction of uterus, participate in the regulation of human parturition...
  73. Role of the Fetus in the Initiation of Parturition
    CAROLE MENDELSON; Fiscal Year: 2004
    ..mice injected with a histone deacetylase inhibitor near term manifested increased histone acetylation in the uterus and delayed parturition, suggesting the functional importance of the decline in coactivators in the initiation of ..