female genitalia

Summary

Summary: The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.

Top Publications

  1. doi Resolving mechanisms of competitive fertilization success in Drosophila melanogaster
    Mollie K Manier
    Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
    Science 328:354-7. 2010
  2. pmc Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selection
    Willie J Swanson
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genetics 168:1457-65. 2004
  3. ncbi Male and female cooperate in the prohormone-like processing of a Drosophila melanogaster seminal fluid protein
    M Park
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Dev Biol 171:694-702. 1995
  4. pmc Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 72:5799-806. 2004
  5. pmc Anogenital distance in human male and female newborns: a descriptive, cross-sectional study
    Eduardo Salazar-Martinez
    National Institute of Public Health, Av Universidad 655, Col Santa Ma Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
    Environ Health 3:8. 2004
  6. ncbi Expression and steroid hormonal control of Muc-1 in the mouse uterus
    G A Surveyor
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Endocrinology 136:3639-47. 1995
  7. pmc Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
    A Wald
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Clin Invest 99:1092-7. 1997
  8. ncbi Hypospadias mimicking female genitalia on early second trimester sonographic examination
    Marwan Odeh
    Department of Obstetrics and Gynecology, Western Galilee Hospital, Rappaport Faculty of Medicine, Technion, Nahariya 22100, Haifa, Israel
    J Clin Ultrasound 36:581-3. 2008
  9. doi Complex female genitalia indicate sperm dumping in armored goblin spiders (Arachnida, Araneae, Oonopidae)
    Matthias Burger
    Division of Invertebrate Zoology, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024, USA
    Zoology (Jena) 113:19-32. 2010
  10. ncbi Anatomical studies of the female genitalia: surgical reconstructive implications
    Laurence S Baskin
    Pediatric Urology, UCSF Children s Medical Center, University of California, Children s Hospital, San Francisco, CA 94143, USA
    J Pediatr Endocrinol Metab 17:581-7. 2004

Research Grants

  1. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2001
  2. GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    Holly Ingraham; Fiscal Year: 2000
  3. GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    Holly Ingraham; Fiscal Year: 1993
  4. GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    Holly Ingraham; Fiscal Year: 1999
  5. Blocking immune evasion as a novel HSV vaccine approach
    Harvey Friedman; Fiscal Year: 2009
  6. Blocking immune evasion as a novel HSV vaccine approach
    HARVEY MICHAEL FRIEDMAN; Fiscal Year: 2010
  7. Blocking immune evasion as a nevel HSV vaccine approach
    Harvey Friedman; Fiscal Year: 2007
  8. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 2007
  9. HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2002
  10. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2007

Detail Information

Publications199 found, 100 shown here

  1. doi Resolving mechanisms of competitive fertilization success in Drosophila melanogaster
    Mollie K Manier
    Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
    Science 328:354-7. 2010
    ..We find that competitive male fertilization success derives from a multivariate process involving ejaculate-female and ejaculate-ejaculate interactions, as well as complex sperm behavior in vivo...
  2. pmc Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selection
    Willie J Swanson
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genetics 168:1457-65. 2004
    ....
  3. ncbi Male and female cooperate in the prohormone-like processing of a Drosophila melanogaster seminal fluid protein
    M Park
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Dev Biol 171:694-702. 1995
    ..The need for molecular cooperation between the sexes for processing of Acp26Aa could restrict its activity to the mated female...
  4. pmc Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 72:5799-806. 2004
    ..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...
  5. pmc Anogenital distance in human male and female newborns: a descriptive, cross-sectional study
    Eduardo Salazar-Martinez
    National Institute of Public Health, Av Universidad 655, Col Santa Ma Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
    Environ Health 3:8. 2004
    ..Because AGD has been an easy-to-measure, sensitive outcome in animals studies, we developed and implemented an anthropometric protocol for measurement of AGD in human males as well as females...
  6. ncbi Expression and steroid hormonal control of Muc-1 in the mouse uterus
    G A Surveyor
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Endocrinology 136:3639-47. 1995
    ..Collectively, these data indicate that Muc-1 expression in mouse uterine epithelium is strongly influenced by ovarian steroids. It is suggested that the loss of Muc-1 contributes to generation of a receptive uterine state...
  7. pmc Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
    A Wald
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Clin Invest 99:1092-7. 1997
    ..HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide...
  8. ncbi Hypospadias mimicking female genitalia on early second trimester sonographic examination
    Marwan Odeh
    Department of Obstetrics and Gynecology, Western Galilee Hospital, Rappaport Faculty of Medicine, Technion, Nahariya 22100, Haifa, Israel
    J Clin Ultrasound 36:581-3. 2008
    ..We therefore suggest that female fetal sex assignment should be based on the demonstration of the 2 or 4 parallel lines representing the labial folds and not only upon the demonstration of the downward direction of the genital tubercle...
  9. doi Complex female genitalia indicate sperm dumping in armored goblin spiders (Arachnida, Araneae, Oonopidae)
    Matthias Burger
    Division of Invertebrate Zoology, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024, USA
    Zoology (Jena) 113:19-32. 2010
    ..Oonopidae are a diverse spider family comprising many species with peculiar female genitalia. Especially in species where studies of mating behavior are difficult, morphological investigations of the ..
  10. ncbi Anatomical studies of the female genitalia: surgical reconstructive implications
    Laurence S Baskin
    Pediatric Urology, UCSF Children s Medical Center, University of California, Children s Hospital, San Francisco, CA 94143, USA
    J Pediatr Endocrinol Metab 17:581-7. 2004
    ..Herein, we review the neuroanatomy of the female genitalia and the implications for the rare patient who needs surgical reconstruction.
  11. pmc Human immunodeficiency virus type 1 genomic RNA sequences in the female genital tract and blood: compartmentalization and intrapatient recombination
    Sean Philpott
    Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
    J Virol 79:353-63. 2005
    ....
  12. ncbi Multiple pyogenic granuloma involving female genitalia: a rare entity?
    Tejinder Kaur
    Pediatr Dermatol 21:614-5. 2004
  13. ncbi Alteration of glutathione reductase expression in the female reproductive organs during the estrous cycle
    T Kaneko
    Department of Biochemistry, Yamagata University School of Medicine, Yamagata, Yamagata 990-9585, Japan
    Biol Reprod 65:1410-6. 2001
    ..Because GSH is known to increase gamete viability and the efficiency of fertility, GR, which is expressed in these tissues, is predicted to play a pivotal role in the reproduction process as a source of GSH...
  14. pmc Coevolution of male and female genital morphology in waterfowl
    Patricia L R Brennan
    Department of Ecology and Evolutionary Biology, and Peabody Natural History Museum, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 2:e418. 2007
    ..Our results suggest that females have evolved a cryptic anatomical mechanism of choice in response to forced extra-pair copulations...
  15. ncbi Silhouettella loricatula (Arachnida, Araneae, Oonopidae): a Haplogyne spider with complex female genitalia
    Matthias Burger
    Natural History Museum, Department of Invertebrates, CH 3005 Bern, Switzerland
    J Morphol 267:663-77. 2006
    ..The microorganisms can be identified partly as bacteria. They are enclosed in secretion and are always found in the same position inside the receptaculum...
  16. ncbi HIV type 1 zidovudine (ZDV) resistance in blood and uterine cervical secretions of pregnant women
    Lisa M Frenkel
    University of Washington, Seattle, Washington 98109, Children s Hospital and Medical Center of Seattle, Seattle, Washington 98105, USA
    AIDS Res Hum Retroviruses 22:870-3. 2006
    ..However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract...
  17. ncbi Determinants of HIV-1 shedding in the genital tract of women
    A Kovacs
    Maternal Child and Adolescent HIV Management and Research Center, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Lancet 358:1593-601. 2001
    ..We aimed to assess the relation between HIV-1 shedding (RNA or culturable virus) in female genital secretions and other factors that might affect HIV-1 shedding...
  18. ncbi Structure and function of the spermathecal complex in the phlebotomine sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae): II. post-copulatory histophysiological changes during the gonotrophic cycle
    K Ilango
    Zoological Survey of India, Southern Regional Station, 130 Santhome High Road, Chennai 600 028, India
    J Biosci 30:733-47. 2005
    ..papatasi. As the females of P. papatasi mate polyandrously, the anatomical and physiological complexity of the spermathecal complex may be related to post-copulatory sexual selection...
  19. ncbi Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring
    Yasuyoshi Nikaido
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Reprod Toxicol 18:803-11. 2004
    ..High-dose GEN and RES and high- and low-dose BPA and DES exerted transient effects on the reproductive tract and mammary glands, whereas ZEA exerted prolonged effects...
  20. ncbi Structure and function of the spermathecal complex in the phlebotomine sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae): I. ultrastructure and histology
    K Ilango
    Zoological Survey of India, Southern Regional Station, Chennai 600 028, India
    J Biosci 30:711-31. 2005
    ..Post-mating sexual selection may be responsible for the structural uniqueness of the spermathecal complex in phlebotomine sandflies...
  21. ncbi Characterization of Toll-like receptors in the female reproductive tract in humans
    A Fazeli
    Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, UK
    Hum Reprod 20:1372-8. 2005
    ....
  22. ncbi Nonantagonistic interactions between the sexes revealed by the ecological consequences of reproductive traits
    L Lacey Knowles
    Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI 48109 1079, USA
    J Evol Biol 18:156-61. 2005
    ....
  23. ncbi [The role of the physician when faced with mutilations of the female genitalia]
    Roger Henrion
    Presse Med 32:1347-8. 2003
  24. pmc HIV-1 in genital tract and plasma of women: compartmentalization of viral sequences, coreceptor usage, and glycosylation
    Kimdar Sherefa Kemal
    New York State Department of Health, Wadsworth Center, 120 New Scotland Avenue, Albany, NY 12208, USA
    Proc Natl Acad Sci U S A 100:12972-7. 2003
    ..These findings are relevant to the prevention and control of HIV-1 infection...
  25. ncbi Sperm-female coevolution in Drosophila
    Gary T Miller
    Department of Biology, Syracuse University, 108 College Place, Syracuse, NY 13244, USA
    Science 298:1230-3. 2002
    ..Giant sperm tails are the cellular equivalent of the peacock's tail, having evolved because females evolved reproductive tracts that selectively bias paternity in favor of males with longer sperm...
  26. doi Pathobiology of triple reassortant H3N2 influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeys
    S P S Pillai
    Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    Vaccine 27:819-24. 2009
    ....
  27. ncbi Copulation behaviour of Glossina pallidipes (Diptera: Muscidae) outside and inside the female, with a discussion of genitalic evolution
    R D Briceño
    Escuela de Biologia, Universidad de Costa Rica, Ciudad Universitaria, Costa Rica
    Bull Entomol Res 97:471-88. 2007
    ..The elaborate copulatory courtship behaviour and male genitalia may provide the stimuli that previous studies showed to induce female ovulation and resistance to remating...
  28. doi The anatomy of fertilization in the yellow dung fly Scathophaga stercoraria
    B I Arthur
    Zoological Museum, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich
    J Morphol 269:630-7. 2008
    ..Such anatomy potentially gives the female a large degree of control over sperm traffic from storage to the site of fertilization...
  29. pmc Female genitalia concealment promotes intimate male courtship in a water strider
    Chang S Han
    Laboratory of Behavioral Ecology and Evolution, School of Biological Sciences, Seoul National University, Seoul, South Korea
    PLoS ONE 4:e5793. 2009
    ..Our results indicate that the apparent victory of coevolutionary arms race by one sex in terms of morphology may trigger evolution of a behavioral phenotype in the opposite sex...
  30. pmc Meeting report: measuring endocrine-sensitive endpoints within the first years of life
    Tye E Arbuckle
    Biostatistics and Epidemiology Division, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 116:948-51. 2008
    ....
  31. ncbi Mucin genes expressed by human female reproductive tract epithelia
    I K Gipson
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Reprod 56:999-1011. 1997
    ....
  32. ncbi Function of multiple sperm storage organs in female Mediterranean fruit flies (Ceratitis capitata, Diptera: Tephritidae)
    Eyal Twig
    Department of Entomology, Hebrew University of Jerusalem, POB 12, Rehovot 76100, Israel
    J Insect Physiol 51:67-74. 2005
    ..We suggest that the use of both organs by females results in sperm economy, which adaptively prolongs the intervals between copulations...
  33. ncbi HIV-1 drug resistance in variants from the female genital tract and plasma
    Kimdar Sherefa Kemal
    Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
    J Infect Dis 195:535-45. 2007
    ..Human immunodeficiency virus type 1 (HIV-1) drug-resistance mutations may arise in a fraction of viral variants, and these variants may differ between compartments, including the genital tract and blood...
  34. ncbi NK cell function in the human female reproductive tract
    Charles L Sentman
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 57:108-15. 2007
    ..Uterine NK cells have a unique phenotype compared with blood NK cell subsets, yet little is known about how NK cells function as a part of the innate immune cell network in the female reproductive tract...
  35. ncbi Disruption of the female reproductive system by the phytoestrogen genistein
    Wendy N Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 23:308-16. 2007
    ..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood...
  36. ncbi The impact of endocrine disrupters on the female reproductive system
    P Nicolopoulou-Stamati
    Department of Pathology, Medical School, University of Athens, Greece
    Hum Reprod Update 7:323-30. 2001
    ..The aim is to present available information, highlighting the impact of endocrine disrupters on the female reproductive system, in order to stimulate reevaluation in identifying hormone disorders...
  37. ncbi Early archives of genetically-restricted proviral DNA in the female genital tract after heterosexual transmission of HIV-1
    Nicolas Chomont
    Universite Paris V, Unité INSERM Internationale d Immunologie Humaine U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, and Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Paris, France
    AIDS 21:153-62. 2007
    ....
  38. ncbi Localization of the Drosophila male accessory gland protein Acp36DE in the mated female suggests a role in sperm storage
    M J Bertram
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
    Insect Biochem Mol Biol 26:971-80. 1996
    ..Facilitation of sperm storage by Acp36DE may also explain the previously observed effect of this protein on sperm competition...
  39. ncbi MUC1/episialin: a critical barrier in the female reproductive tract
    M M DeSouza
    Department of Biological Sciences, University of Delaware, Newark 19716 2590, USA
    J Reprod Immunol 45:127-58. 1999
    ..Collectively, these studies demonstrate a critical barrier role for Muc1 in various aspects of female reproductive tract physiology...
  40. ncbi Colocalization of polyol-metabolizing enzymes and immunological detection of fructated proteins in the female reproductive system of the rat
    Tomoko Kaneko
    Department of Biochemistry, Yamagata University School of Medicine, 2 2 2 Iidanishi, 990 9585 Yamagata, Japan
    Histochem Cell Biol 119:309-15. 2003
    ..The abundance of AR compared with SDH suggests that it also plays an additional role in the reproductive system, which might include a source of reducing power and protection against toxic carbonyl compounds...
  41. ncbi Induction of gonadal toxicity to female rats after chronic exposure to mancozeb
    P N Baligar
    Post-graduate Department of Studies in Zoology, Karnatak University, Dharwad, India
    Ind Health 39:235-43. 2001
    ..These observed effect of mancozeb on the estrous cycle, follicles and biochemical constituents may be due to imbalance in the hormone or toxic effect...
  42. ncbi Possible coevolution of male and female genital form and function in a calopterygid damselfly
    A Córdoba-Aguilar
    Instituto de Ecologia, Universidad Nacional Autonoma de Mexico, Mexico, DF
    J Evol Biol 18:132-7. 2005
    ..A suggested coevolutionary interpretation of these results in C. haemorrhoidalis is that aedeagal width was favoured which was followed by a sensillum reduction...
  43. ncbi Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats
    Sang Hee Jeong
    Toxicology Division, National Veterinary Research and Quarantine Service, 480, Anyang 430 016, Republic of Korea
    Toxicology 208:49-62. 2005
    ....
  44. ncbi Xenoendocrine pollutants may reduce size of sexual organs in East Greenland polar bears (Ursus maritimus)
    Christian Sonne
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, P O Box 358, DK 4000 Roskilde, Denmark
    Environ Sci Technol 40:5668-74. 2006
    ..This may pose a riskto this polar bear subpopulation in the future because of reduced sperm and egg quality/quantity and uterus and penis size/robustness...
  45. pmc Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice
    Rachel L Ruhlen
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 116:322-8. 2008
    ..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful...
  46. ncbi Effect of gestational exposure to nonylphenol on the development and fertility of mouse offspring
    Naoko Kimura
    Laboratory of Animal Reproduction, Faculty of Agricultural Science, Yamagata University, Tsuruoka, Japan
    J Reprod Dev 52:789-95. 2006
    ..9%) and NP1/10 (female: 9.8%) groups. These results suggest that exposure to NP in utero possibly affects the body weight and some reproductive organ weights, but does not influence the potential fertility of the F1 generation...
  47. pmc Reproductive biology of the pampas deer (Ozotoceros bezoarticus): a review
    Rodolfo Ungerfeld
    Departamento de Fisiologia, Facultad de Veterinaria, Montevideo, Uruguay
    Acta Vet Scand 50:16. 2008
    ..Finally, an overview is given and future directions of research are proposed...
  48. ncbi Effects of in utero and lactational exposure to di(2-ethylhexyl)phthalate on somatic and physical development in rat offspring
    Kenichi Kobayashi
    National Institute of Occupational Safety and Health, Nagao, Kawasaki, Japan
    Ind Health 44:652-60. 2006
    ....
  49. ncbi Reproductive morphology of Brittanichthys axelrodi (Teleostei: Characidae), a miniature inseminating fish from South America
    Robert Javonillo
    Department of Biological Sciences, The George Washington University, Washington, District of Columbia 20052, USA
    J Morphol 268:23-32. 2007
    ..These morphological features are likely linked to the reproductive mode of insemination, a trait that is so far as known, relatively rare among teleost fishes, but is proving increasingly frequent among certain groups of characid fishes...
  50. ncbi Functional morphology of the reproductive system of Galathea intermedia (Decapoda: Anomura)
    Katrin Kronenberger
    Forschungsinstitut und Naturmuseum Senckenberg, 60325 Frankfurt am Main, Germany
    J Morphol 262:500-16. 2004
    ..No trace of a female reproductive system could be detected. Thus, these external intersexes are exclusively functional males...
  51. ncbi Effect of exposure to high isoflavone-containing diets on prenatal and postnatal offspring mice
    Kyoka Takashima-Sasaki
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University
    Biosci Biotechnol Biochem 70:2874-82. 2006
    ..These results suggest that chronic exposure to higher than normal levels of IF induces alterations in the reproductive development of female mice through an estrogenic effect...
  52. ncbi Developmental effects of ethinylestradiol on reproductive organs of female mice
    Akiko Kirigaya
    Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa Ku, Yokohama 236 0027, Japan
    In Vivo 20:867-73. 2006
    ..Thus, it is clear that prenatal exposure to EE2 or DES induces reproductive abnormalities, including PF, ovary-independent vaginal epithelial stratification and cornification...
  53. ncbi Novelties of conception in insectivorous mammals (Lipotyphla), particularly shrews
    J Michael Bedford
    Center for Reproductive Medicine and Infertility, Weill Medical College, Cornell University, New York, NY 10021, USA
    Biol Rev Camb Philos Soc 79:891-909. 2004
    ....
  54. ncbi Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system
    Erdal Budak
    Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain
    Fertil Steril 85:1563-81. 2006
    ....
  55. ncbi Endogenous retroviruses and animal reproduction
    S Prudhomme
    UMR 2142 CNRS bioMérieux, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    Cytogenet Genome Res 110:353-64. 2005
    ..We conclude with an insight on the evolutionary and epigenetic consequences of the relationships of ERV guests with their animal hosts...
  56. ncbi Comparative performance of the Roche COBAS Amplicor assay and an in-house real-time PCR assay for diagnosis of Chlamydia trachomatis infection
    Hamid Jalal
    Clinical Microbiology and Public Health Laboratory, Box 236, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QW, UK
    J Med Microbiol 56:320-2. 2007
    ..The sensitivity of IHRT-PCR was comparable with, and specificity was higher than, Amplicor PCR for the diagnosis of genital chlamydial infection...
  57. ncbi Effects of altered food intake during pubertal development in male and female wistar rats
    Susan C Laws
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 100:194-202. 2007
    ....
  58. ncbi Multigeneration reproductive and developmental toxicity study of bar gene inserted into genetically modified potato on rats
    Gyu Seek Rhee
    Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul
    J Toxicol Environ Health A 68:2263-76. 2005
    ..The results suggest that genetically modified crops have no adverse effects on the multigeneration reproductive-developmental ability...
  59. ncbi PELVIS Syndrome
    Céline Girard
    Department of Dermatology, Hopital Saint Eloi, Centre Hospitalier Regional Universitaire, Montpellier, France
    Arch Dermatol 142:884-8. 2006
    ..Large perineal hemangiomas can be associated with congenital anomalies, including anorectal, urinary tract, spine, and external genitalia malformations...
  60. ncbi Decrease of genital organ weights and plasma testosterone levels in rats following oral administration of leuprolide microemulsion
    Jack Y Zheng
    Global Pharmaceutical R and D, Formulation Development Center, Abbott Laboratories, North Chicago, IL 60064 6246, USA
    Int J Pharm 307:209-15. 2006
    ..These findings suggest that systemic absorption of highly water-soluble protein or peptide drugs could be enhanced by oral microemulsions containing oleic acid...
  61. ncbi Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effect
    Osamu Takahashi
    Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health, 24 1, Hyakunincho 3 chome, 169 0073 Shinjuku ku, Tokyo, Japan
    Arch Toxicol 80:225-41. 2006
    ..These results suggest that BM and TM are weakly toxic, possibly through an estrogenic mechanism to male reproductive organs in mice as well as rats, while MM and ME may be the direct testicular toxins in rats but not mice...
  62. ncbi Ultrastructural evidence for secretion from the epithelium of ampulla ductus deferentis of the fan-throated lizard Sitana ponticeriana Cuvier
    M A Akbarsha
    Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India
    J Morphol 266:94-111. 2005
    ..It appears that within the Squamata, the ductal ampulla differs in structure as well as function. We suggest that the ductal ampulla of agamid lizards is a composite gland of the ampulla ductus deferentis and seminal vesicles of mammals...
  63. ncbi Reproductive tract infections in horses
    Kristina G Lu
    Hagyard Equine Medical Institute, 4250 Iron Works Pike, Lexington, KY 40511, USA
    Vet Clin North Am Equine Pract 22:519-52, x. 2006
    ..Only then can a rational treatment plan be formulated. Many recent advances in knowledge about the reproductive system of multiple species have application to the mare and stallion...
  64. ncbi Effect of cigarette smoke on body weight, food intake and reproductive organs in adult albino rats
    Sumedha S Audi
    Department of Physiology, Goa Medical College, Bambolim Goa, 403 202, India
    Indian J Exp Biol 44:562-5. 2006
    ..The number of sperms was less in the testes. The results show that exposure to cigarette smoke is detrimental to the reproductivity in both, male and female albino rats...
  65. ncbi A synthetic gonadotropin-releasing hormone (GnRH) vaccine for control of fertility and hormone dependent diseases without any adjuvant
    Xu Jinshu
    The Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Tong Jia Xiang 24, Nanjing 210009 Jiangsu, PR China
    Vaccine 23:4834-43. 2005
    ....
  66. ncbi Multigenerational exposure to phytosterols in the mouse
    Ari Ryökkynen
    Department of Biology, University of Joensuu, P O Box 111, FIN 80101, Joensuu, Finland
    Reprod Toxicol 19:535-40. 2005
    ..PS supplement also increased the testicular levels of testosterone in the male pups of F(2) generation. In spite of these transitory changes, PS exposure caused no permanent deleterious effects on the reproduction of the mouse...
  67. ncbi Effects of in utero and lactational exposure to tamoxifen in SD rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicol Lett 156:289-96. 2005
    ..6 and 3 microg/kg/day groups. No abnormalities were detected in the reproductive performance of the male and female offspring...
  68. ncbi Characteristics and fate of the spermatozoa of Inachus phalangium (Decapoda, Majidae): description of novel sperm structures and evidence for an additional mechanism of sperm competition in Brachyura
    Rocco Rorandelli
    Dipartimento di Biologia Animale e Genetica Leo Pardi, University of Florence, 50125 Florence, Italy
    J Morphol 269:259-71. 2008
    ....
  69. ncbi Phytoestrogens alter the reproductive organ development in the mink (Mustela vison)
    Ari Ryökkynen
    Department of Biology, University of Joensuu, PO Box 111, FIN 80101 Joensuu, Finland
    Toxicol Appl Pharmacol 202:132-9. 2005
    ..This study could not explain the mechanisms behind these alterations. The results indicate that perinatal phytoestrogen exposures cause alterations in the weight of the reproductive organs of the mink kits...
  70. ncbi HOX-4 genes and the morphogenesis of mammalian genitalia
    P Dolle
    European Molecular Biology Laboratory, Heidelberg, Germany
    Genes Dev 5:1767-7. 1991
    ..We also show that genital tubercle mesenchyme can respecify pattern in the chicken wing bud. This finding reinforces the concept of the uniformity in the patterning mechanisms along the various axes of the body...
  71. ncbi Vaginal reconstruction for ambiguous genitalia and congenital absence of the vagina: a 27-year experience
    Kathleen Graziano
    Section of Pediatric Surgery, Department of Surgery, the C S Mott Children s Hospital and the University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Pediatr Surg 37:955-60. 2002
    ..Patients with an absent vagina require the construction of an artificial vagina. In an effort to improve care, the authors have categorized their experience with this group of children...
  72. ncbi A historical survey of scintigraphic methodology for evaluation of the reproductive tract
    L S Zuckier
    Department of Radiology, Section of Nuclear Medicine, New Jersey Medical School, Newark, NJ, USA
    Q J Nucl Med 46:160-8. 2002
    ..Consideration of these methods will potentially stimulate future development and application of radionuclide techniques to emerging questions in the fields of reproductive and genital physiology...
  73. ncbi Mode of transfer of spermatozoa in Orthoptera Tettigoniidae
    Renata Viscuso
    Dipartimento di Biologia Animale Marcello La Greca, Universita di Catania, Via Androne 81, 95124 Catania, Italy
    Tissue Cell 34:337-48. 2002
    ..As regards their role, it is hypothesized that these structures represent a long-term conservation mechanism for spermatozoa inside the seminal receptacle...
  74. ncbi A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals
    Kazushi Okazaki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Arch Toxicol 76:553-9. 2002
    ..However, the findings indicate that chemicals with weak endocrine-disrupting potential like genistein must be evaluated taking into consideration the results of other test systems...
  75. ncbi Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocuta
    Ned J Place
    Department of Psychology, University of California, Berkeley, California 94720, USA
    Biol Reprod 67:1405-13. 2002
    ....
  76. pmc Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male mating
    C M Drea
    Department of Psychology, University of California at Berkeley, Berkeley, CA 94720, USA
    Proc Biol Sci 269:1981-7. 2002
    ..Moreover, the same androgens that render an extremely unusual and laborious process even more reproductively costly in the female are apparently essential to the male's physical ability to reproduce with a normally masculinized female...
  77. ncbi In vitro and in vivo effects of 17beta-trenbolone: a feedlot effluent contaminant
    Vickie S Wilson
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 70:202-11. 2002
    ..In summary, TB is a potent environmental androgen both in vitro and in vivo and, in contrast to other reports, can induce developmental abnormalities in the fetus...
  78. ncbi Avian reproductive anatomy, physiology and endocrinology
    Christal G Pollock
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506 5606, USA
    Vet Clin North Am Exot Anim Pract 5:441-74. 2002
    ..Incubation is associated with falling LH levels and rising prolactin levels. If the hen actually enters reproductive quiescence at this time, then molt will follow. Molt is associated with the total regression of the reproductive tract...
  79. ncbi Reproductive medicine in koi (Cyprinus carpio)
    Gregory A Lewbart
    Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    Vet Clin North Am Exot Anim Pract 5:637-48, vii. 2002
    ..In this country and in many parts of the world we refer to these fish as koi. Reproductive medicine problems are well documented in koi and a thorough knowledge of this subject will aid the fish practitioner in diagnosis and treatment...
  80. ncbi Humoral immune responses to microbial infections in the genital tract
    Michael W Russell
    Department of Microbiology, and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, NY 14214, USA
    Microbes Infect 4:667-77. 2002
    ..Antibody responses to genital infections or to locally applied vaccines are usually modest, but alternative strategies for eliciting genital tract antibodies are being developed...
  81. ncbi Decreased sperm number and motile activity on the F1 offspring maternally exposed to butyl p-hydroxybenzoic acid (butyl paraben)
    Kyung Sun Kang
    Department of Veterinary Public Health, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Korea
    J Vet Med Sci 64:227-35. 2002
    ..Taken together, these results indicated that maternal exposure of BP might have adverse effects on the F1 male offspring...
  82. ncbi Impairment of male rat reproductive function in F1 offspring from dams exposed to 2-bromopropane during gestation and lactation
    Kyung Sun Kang
    Department of Veterinary Public Health, College of Veterinary Medicine, School of Agricultural Biotechnology, Seoul National University, 103 Seodun dong, Kwonsun Gu, Suwon, 441 744, Korea
    Reprod Toxicol 16:151-9. 2002
    ..These results suggest that gestational and lactational exposure to 2-BP at a high maternally toxic dose impairs the development of the reproductive organs of the offspring...
  83. ncbi Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression
    G V Benson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 122:2687-96. 1996
    ..These results show that Hoxa-10 is required during morphogenesis for proper patterning of the reproductive tract and in the adult uterus for peri-implantation events...
  84. pmc Reproductive isolation and morphogenetic evolution in Drosophila analyzed by breakage of ethological barriers
    L Sanchez
    Centro de Investigaciones Biologicas, Velazquez, Madrid, Spain
    Genetics 147:231-42. 1997
    ..The effect on the terminalia of teissieri-melanogaster hybrids of a mutation in doublesex, a regulatory gene that controls the development of the terminalia, was also investigated...
  85. ncbi Glycodelin mRNA is expressed in the genital tract of male and female rats (Rattus norvegicus)
    C Keil
    Institute of Biochemistry, Ernst Moritz Arndt University, Klinikum, Sauerbruchstrasse, D 17487 Greifswald, Germany
    J Mol Endocrinol 23:57-66. 1999
    ..The expression in several reproductive organs of rats offers an excellent tool to study further the physiological role of glycodelin, which is so far thought to act as an immunosuppressive factor...
  86. ncbi Genetic control of fertility and embryonic waste in the mouse: A rolefor angiotensinogen
    C B Tempfer
    Department of Obstetrics and Gynecology and Department of Human and Molecular Genetics, Baylor Collegeof Medicine, Houston, Texas 77030, USA
    Biol Reprod 62:457-62. 2000
    ..001). We conclude that Agt deficiency is associated with an in utero lethal effect, decreased fertility, and impaired neonatal survival...
  87. ncbi Role of early GnRH administration in sexual behavior disorders of rat pups perinatally exposed to lead
    H S Spinosa
    Department of Pathology, Faculty of Veterinary Medicine and Zootechny, , , Brazil
    Neurotoxicol Teratol 23:203-12. 2001
    ..These results show that perinatal exposure to Pb had a dose-dependent effect on the sexual behavior of rats and that a decrease in GnRH source in the offspring was probably involved in the reduction of their sexual performance...
  88. ncbi 1-Stage feminizing genitoplasty: 8 years of experience with 49 cases
    A Farkas
    Department of Urology, Shaare Zedek Medical Center, Faculty of Health Science, Ben-Gurion University, Jerusalem, Israel
    J Urol 165:2341-6. 2001
    ..CONCLUSIONS: Our adapted technique of 1-stage feminizing genitoplasty provides good cosmetic and functional results. The functional results of this operation should be reevaluated after puberty and in adulthood...
  89. ncbi Toxicological evaluations of long-term consumption of Solanum lycocarpum St. Hill fruits in male and female adult rats
    V M Maruo
    Department of Pathology, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Brazil
    Phytomedicine 10:48-52. 2003
    ..The present data, however, show sex-related differences in S. lycocarpum toxicity. Thus, other studies have to be conducted to better investigate female toxicity and other toxic effects of higher levels of exposure to this plant...
  90. ncbi Experimental transmission of Trypanosoma cruzi through the genitalia of albino mice
    L Herrera
    , , Facultad de Ciencias, Universidad Central de Venezuela, Caracas 104l-A, Venezuela
    Mem Inst Oswaldo Cruz 96:713-7. 2001
    ..cruzi with genital mucosa can produce blood and tissue infections. These results are discussed in relation to reports of frequent experimental tropism of T. cruzi toward urogenital organs...
  91. ncbi Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study
    Cynthia J Wolf
    Reproductive Toxicology Division, Endocrinology Branch, MD 72, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, 86 Alexander Drive, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 65:71-86. 2002
    ..This study provides a useful model for in utero testing of environmental androgens for their potential to induce developmental abnormalities...
  92. ncbi [Cytotoxic effects of lead on the endocrine and exocrine sexual function of pubescent male and female rats. Demonstration of apoptotic activity]
    Fatma Gorbel
    Laboratoire d éco physiologie animale, Faculte des Sciences de Sfax, 3018 Sfax, Tunisie
    C R Biol 325:927-40. 2002
    ..The cytotoxic effect of lead in males seems to be related to an apoptotic process...
  93. ncbi [Congenital genital anomalies. Aspects of diagnostics and treatment]
    Indre Zaparackaite
    Clinic of Paediatric Surgery, Kaunas University of Medicine, Eiveniu 2, 3007 Kaunas, Lithuania
    Medicina (Kaunas) 39:105-13. 2003
    ....
  94. ncbi Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review
    W Kordan
    University of Warmia and Mazury in Olsztyn, Faculty of Animal Bioengineering, Department of Animal Biochemistry and Biotechnology, 10 718 Olsztyn, Poland
    Pol J Vet Sci 6:55-60. 2003
    ..This review also addressed the importance of the mechanism regulating PAF metabolism, PAF-acetylhydrolase (PAF-AH), during the membrane fusion events associated with fertilization...
  95. ncbi Emerging roles for hedgehog-patched-Gli signal transduction in reproduction
    David O Walterhouse
    Children s Memorial Hospital and the Children s Memorial Institute for Education and Research, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Biol Reprod 69:8-14. 2003
    ....
  96. ncbi Angiotensin I-converting enzyme (ACE) activity of the tomato moth, Lacanobia oleracea: changes in levels of activity during development and after copulation suggest roles during metamorphosis and reproduction
    U V Ekbote
    Molecular and Cellular Biosciences, Faculty of Biological Sciences, University of Leeds, LC Miall Building, Clarendon Way, Leeds LS2 9JT, UK
    Insect Biochem Mol Biol 33:989-98. 2003
    ..Evidence for such a proteolytic pathway and its role in providing substrates for the TCA cycle has been obtained previously in a study of reproduction in Bombyx mori...
  97. pmc Effects of p-nonylphenol and resveratrol on body and organ weight and in vivo fertility of outbred CD-1 mice
    Vendula Kyselova
    Department of Biology and Biochemistry of Fertilization, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Reprod Biol Endocrinol 1:30. 2003
    ..The litter sex ratio was not different from controls. Unlike RES, NP had a negative effect on spermatogenesis and sperm quality with a resultant impact on in vivo fertility...
  98. ncbi Handling during pregnancy in the blue fox (Alopex lagopus): the influence on the fetal gonadal function
    Ludmila V Osadchuk
    Institute of Cytology and Genetics, Siberian Department of the Russian Academy of Sciences, Novosibirsk, 630090, Russia
    Gen Comp Endocrinol 132:190-7. 2003
    ..0.8+/-0.02 cm, P<0.01). These results indicate that prenatal stress resulted in a significant reduction of hormonal and morphometric measures of the reproductive system in blue fox fetuses with more drastic effects in female fetuses...
  99. ncbi Clinical implications of rhinoceros reproductive tract anatomy and histology
    N E Schaffer
    SOS Rhino, 680 North Lake Shore Drive, Suite 807, Chicago, Illinois 60611, USA
    J Zoo Wildl Med 32:31-46. 2001
    ..Defining this unique morphology of rhinoceroses may help in understanding their reproductive physiology and will effect the development of appropriate reproductive techniques...
  100. ncbi Reproductive physiology of free-living White Ibises (Eudocimus albus) in the Florida Everglades
    Julie A Heath
    Department of Biology, Hofstra University, Hempstead, NY 11549, USA
    Gen Comp Endocrinol 133:118-31. 2003
    ..White Ibises showed similar patterns in reproductive physiology to other monogamous, seasonally breeding bird species in which both sexes incubate and care for the young...
  101. ncbi Gross anatomy and ultrasonographic images of the reproductive system of the Sumatran rhinoceros (Dicerorhinus sumatrensis)
    Z Zainal Zahari
    Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Anat Histol Embryol 31:350-4. 2002
    ..Two lateral projections were located at the base of the penis. A well-defined process glandis was present at the tip of the penis. The accessory sex glands and the testes could be imaged by ultrasonography...

Research Grants129 found, 100 shown here

  1. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2001
    ..Topical application of traditional nitric oxide donors to the female genitalia, however, produces profound systemic side effects, including headache and hypotension...
  2. GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    Holly Ingraham; Fiscal Year: 2000
    ..the secretion of MIS results in the regression or "cell death" of the Mullerian duct, the anlagen of internal female genitalia. Thus, regulation of MIS gene expression is directly coupled to the differentiation of the Sertoli cell and ..
  3. GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    Holly Ingraham; Fiscal Year: 1993
    ..the secretion of MIS results in the regression or "cell death" of the Mullerian duct, the anlagen of internal female genitalia. Thus, regulation of MIS gene expression is directly coupled to the differentiation of the Sertoli cell and ..
  4. GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    Holly Ingraham; Fiscal Year: 1999
    ..the secretion of MIS results in the regression or "cell death" of the Mullerian duct, the anlagen of internal female genitalia. Thus, regulation of MIS gene expression is directly coupled to the differentiation of the Sertoli cell and ..
  5. Blocking immune evasion as a novel HSV vaccine approach
    Harvey Friedman; Fiscal Year: 2009
    ..vaginal and flank models to address whether gD subunit vaccines are more effective at protecting mucosal (female genitalia) than epidermal (male genitalia) sites...
  6. Blocking immune evasion as a novel HSV vaccine approach
    HARVEY MICHAEL FRIEDMAN; Fiscal Year: 2010
    ..vaginal and flank models to address whether gD subunit vaccines are more effective at protecting mucosal (female genitalia) than epidermal (male genitalia) sites...
  7. Blocking immune evasion as a nevel HSV vaccine approach
    Harvey Friedman; Fiscal Year: 2007
    ..vaginal and flank models to address whether gD subunit vaccines are more effective at protecting mucosal (female genitalia) than epidermal (male genitalia) sites...
  8. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 2007
    ....
  9. HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2002
    ..abstract_text> ..
  10. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2007
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  11. Alteration of HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2009
    ..We hypothesize that the effects are maintained long after exposure through epigenetic mechanisms such as methylation of HOX genes. ..
  12. Center for Endometrial Biology and Endometriosis
    Hugh Taylor; Fiscal Year: 2008
    ..The Center also contains three Cores. An Administrative Core, a Cell and Tissue Core and Mouse Modeling Core will be used by each of the investigators and complete a comprehensive Center. ..
  13. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2002
    ....
  14. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
    ....
  15. Alteration of HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2008
    ..We hypothesize that the effects are maintained long after exposure through epigenetic mechanisms such as methylation of HOX genes. ..
  16. HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2003
    ..abstract_text> ..
  17. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2005
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  18. HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2004
    ..abstract_text> ..
  19. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    Charles Wira; Fiscal Year: 2009
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides and therapeutic interventions. ..
  20. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2004
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  21. HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  22. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    Charles Wira; Fiscal Year: 2008
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides and therapeutic interventions. ..
  23. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 2009
    ....
  24. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2003
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  25. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2006
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  26. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    CHARLES ROBERT WIRA; Fiscal Year: 2010
    ....
  27. Alteration of HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh S Taylor; Fiscal Year: 2010
    ..We hypothesize that the effects are maintained long after exposure through epigenetic mechanisms such as methylation of HOX genes. ..
  28. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    CHARLES ROBERT WIRA; Fiscal Year: 2010
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides and therapeutic interventions. ..
  29. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 1993
    ..If SC and/or IgA mRNA is hormonally regulated, then synthesis of message will be analyzed. In situ hybridization studies will be carried out to identify cells in the reproductive tract that synthesize SC and IgA...
  30. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    Charles Wira; Fiscal Year: 2007
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides and therapeutic interventions. ..
  31. Alteration of HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2007
    ..We hypothesize that the effects are maintained long after exposure through epigenetic mechanisms such as methylation of HOX genes. ..
  32. HOX Gene Expression by Endocrine Disrupting Chemicals
    Hugh Taylor; Fiscal Year: 2001
    ..abstract_text> ..
  33. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2001
    ....
  34. Center for Endometrial Biology and Endometriosis
    Hugh Taylor; Fiscal Year: 2007
    ..The Center also contains three Cores. An Administrative Core, a Cell and Tissue Core and Mouse Modeling Core will be used by each of the investigators and complete a comprehensive Center. ..
  35. SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEM
    Charles Wira; Fiscal Year: 2008
    ....
  36. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    Charles Wira; Fiscal Year: 2007
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides, therapeutic interventions, ..
  37. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2000
    ....
  38. Novel VLP-Based Mucosal and Sytemic HIV Vaccines
    Jiri Mestecky; Fiscal Year: 2007
    ..Proposed studies will be executed in collaboration with external investigators from various US institutions, and the direction, approaches and generated results will be discussed with members of the Advisory Group. ..
  39. T-cell mediated immunity in chlamydia genital infection
    Kathleen Kelly; Fiscal Year: 2009
    ....
  40. Pelvic Floor Changes Before and After Birth
    Rebecca Rogers; Fiscal Year: 2009
    ..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
  41. Pelvic Floor Changes Before and After Birth
    Rebecca Rogers; Fiscal Year: 2006
    ..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
  42. Effect of Microbicides on Mucosal HIV Transmission
    Christopher Miller; Fiscal Year: 2003
    ..Further, these studies will determine if individuals that consistently and correctly use of microbicides in the face of repeated viral exposure develop anti-viral immune responses or local infection. ..
  43. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  44. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn Sommers; Fiscal Year: 2009
    ..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  45. ANTIGENS OF STREPTOCOCCUS MUTANS IN CARIES IMMUNITY
    Michael Russell; Fiscal Year: 2008
    ..p RESEARCHGRANT TABLE OF CONTENTS Page Numbers Face Page ................................................................................................................................................ 1 Description, ..
  46. MUCOSAL VACCINES AGAINST GONORRHEA
    Michael Russell; Fiscal Year: 2001
    ..The information gained about genital tract immunity and the techniques used may also be applicable to other sexually transmitted diseases. ..
  47. Sensitivity of the Colposcopy Exam After Sexual Assault
    Marilyn Sommers; Fiscal Year: 2004
    ..2) When viewed as colposcopic photons, what is the difference in number, type and location of injury to the female genitalia and/or anus after consensual versus non-consensual sex? 3) What are the differences in the sensitivity and ..
  48. Effect of Microbicides on Mucosal HIV Transmission
    Christopher Miller; Fiscal Year: 2004
    ..Further, these studies will determine if individuals that consistently and correctly use of microbicides in the face of repeated viral exposure develop anti-viral immune responses or local infection. ..
  49. Cervical T Cell Immunity to C. trachomatis
    ALISON QUAYLE; Fiscal Year: 2008
    ..trachomatis and the cervical immune system that will ultimately aid greatly in delineating protective immune responses against C. trachomatis and the development of effective vaccines. ..
  50. Cell-mediated immune responses to HIV-1 in GALT
    Barbara Shacklett; Fiscal Year: 2004
    ..We will also test alternate hypotheses to explain the apparent low levels of perforin expression in GALT. ..
  51. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 1999
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  52. Frequency and Function of HIV-specific T-cells in GALT
    Barbara Shacklett; Fiscal Year: 2003
    ..We will also test alternate hypotheses to explain the apparent low levels of perforin expression in GALT. ..
  53. HIV-Specific T Cell Responses in Rectal Mucosa
    Barbara L Shacklett; Fiscal Year: 2010
    ..Taken together, these studies should greatly advance our understanding of the HIV-host relationship in mucosal tissues during chronic infection. ..
  54. Sensitivity of the Colposcopy Exam After Sexual Assault
    Marilyn Sommers; Fiscal Year: 2003
    ..2) When viewed as colposcopic photons, what is the difference in number, type and location of injury to the female genitalia and/or anus after consensual versus non-consensual sex? 3) What are the differences in the sensitivity and ..
  55. HIV-Specific T Cell Responses in Rectal Mucosa
    Barbara Shacklett; Fiscal Year: 2008
    ..Taken together, these studies should greatly advance our understanding of the HIV-host relationship in mucosal tissues during chronic infection. ..
  56. Sensitivity of the Colposcopy Exam After Sexual Assault
    Marilyn Sommers; Fiscal Year: 2002
    ..2) When viewed as colposcopic photons, what is the difference in number, type and location of injury to the female genitalia and/or anus after consensual versus non-consensual sex? 3) What are the differences in the sensitivity and ..
  57. Injury in Latina Women after Sexual Assault: Moving Toward Health Care Equity
    MARILYN S contact SOMMERS; Fiscal Year: 2010
    ..The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  58. Injury in Latina Women after Sexual Assault: Moving Toward Health Care Equity
    MARILYN S contact SOMMERS; Fiscal Year: 2010
    ..The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  59. Injury in Latina Women after Sexual Assault: Moving Toward Health Care Equity
    Marilyn Sommers; Fiscal Year: 2009
    ..The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  60. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn Sommers; Fiscal Year: 2007
    ..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  61. HIV-Specific T Cell Responses in Rectal Mucosa
    Barbara L Shacklett; Fiscal Year: 2010
    ..Taken together, these studies should greatly advance our understanding of the HIV-host relationship in mucosal tissues during chronic infection. ..
  62. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn Sommers; Fiscal Year: 2009
    ..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  63. HIV-Specific T Cell Responses in Rectal Mucosa
    Barbara Shacklett; Fiscal Year: 2009
    ..Taken together, these studies should greatly advance our understanding of the HIV-host relationship in mucosal tissues during chronic infection. ..
  64. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn S Sommers; Fiscal Year: 2010
    ..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  65. Cell-mediated immune responses to HIV-1 in GALT
    Barbara Shacklett; Fiscal Year: 2007
    ..We will also test alternate hypotheses to explain the apparent low levels of perforin expression in GALT. ..
  66. HIV-Specific T-cells in cerebrospinal fluid (CSF)
    Barbara Shacklett; Fiscal Year: 2003
    ..We also hypothesize that there may be a correlation between intrathecal HIV viral load and T-cell recruitment to CSF, and that the presence of CTL in CSF may be predictive of neurological disease. ..
  67. Cell-mediated immune responses to HIV-1 in GALT
    Barbara Shacklett; Fiscal Year: 2003
    ..We will also test alternate hypotheses to explain the apparent low levels of perforin expression in GALT. ..
  68. Cell-mediated immune responses to HIV-1 in GALT
    Barbara Shacklett; Fiscal Year: 2005
    ..We will also test alternate hypotheses to explain the apparent low levels of perforin expression in GALT. ..
  69. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn Sommers; Fiscal Year: 2008
    ..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  70. Cell-mediated immune responses to HIV-1 in GALT
    Barbara Shacklett; Fiscal Year: 2006
    ..We will also test alternate hypotheses to explain the apparent low levels of perforin expression in GALT. ..
  71. Pelvic Floor Changes Before and After Birth
    Rebecca Rogers; Fiscal Year: 2007
    ..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
  72. Pelvic Floor Changes Before and After Birth
    Rebecca Rogers; Fiscal Year: 2008
    ..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
  73. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2010
    ..Our new approach also preserves the spinal reflex functions for bowel and sexual organ, and more importantly provides people with SCI the opportunity to benefit from advances in neural regeneration and repair techniques in the future. ..
  74. Concurrent HAART and Tuberculosis Treatment: Drug to Drug Interactions
    Awewura Kwara; Fiscal Year: 2008
    ....
  75. Validation of Sensorized Breast Models for High-Stakes Clinical Skills Assessment
    Carla M Pugh; Fiscal Year: 2010
    ..Our results will help set clinical performance standards. ..
  76. Mechanisms of HIV-1 Transmission in the Genital Mucosa of Women
    Florian Hladik; Fiscal Year: 2008
    ..In this proposal, we will use a novel organ culture model of human vaginal tissue obtained from surgeries to characterize the entry pathways of HIV during the earliest stages of sexual transmission. [unreadable] [unreadable] [unreadable]..
  77. Mechanisms of HIV-1 Transmission in the Genital Mucosa of Women
    Florian Hladik; Fiscal Year: 2007
    ..In this proposal, we will use a novel organ culture model of human vaginal tissue obtained from surgeries to characterize the entry pathways of HIV during the earliest stages of sexual transmission. [unreadable] [unreadable] [unreadable]..
  78. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2004
    ..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
  79. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2006
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. [unreadable] [unreadable]..
  80. BIOMARKERS FOR ANAL CANCER
    Stephen Hawes; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  81. RCT OF STEPPING STONES BEHAVIOURAL INTERVENTION FOR HIV
    Rachel Jewkes; Fiscal Year: 2005
    ..It will also seek to understand what are the barriers to behavior change and what strategies are used by which people to circumnavigate these. ..
  82. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2006
    ..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
  83. PHYSIOLOGY OF PUBERTY AND ANTISOCIAL BEHAVIOR
    Elizabeth Susman; Fiscal Year: 2003
    ..The study will fill a major void in the literature as it aims to assess both the effect of hormones on behavior and the neurobiological effect of antisocial behavior on hormone concentrations. ..
  84. Concurrent HAART and Tuberculosis Treatment: Drug to Drug Interactions
    Awewura Kwara; Fiscal Year: 2007
    ....
  85. Assessment of Penile Autonomic Innervation
    Claire Yang; Fiscal Year: 2007
    ..The ability to detect cavernous neuropathy is relevant to the evaluation of erectile dysfunction, as well as the development of disease-specific treatments for neurogenic erectile dysfunction. [unreadable] [unreadable]..
  86. PHYSIOLOGY OF PUBERTY AND ANTISOCIAL BEHAVIOR
    Elizabeth Susman; Fiscal Year: 2001
    ..The study will fill a major void in the literature as it aims to assess both the effect of hormones on behavior and the neurobiological effect of antisocial behavior on hormone concentrations. ..