Genomes and Genes
Summary: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Publications219 found, 100 shown here
- Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewalPallab Maity
Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
J Biol Chem 283:14391-401. 2008..that lansoprazole activates vascular epidermal growth factor-mediated controlled angiogenesis to repair gastric mucosa. Lansoprazole also stimulates the healing of already formed ulcers induced by indomethacin...
- Role of innate immunity in Helicobacter pylori-induced gastric malignancyRichard M Peek
Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232 2279, USA
Physiol Rev 90:831-58. 2010..pylori-infected individuals who can then be targeted for therapeutic intervention...
- Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin CT Pohle
Department of Medicine B, University of Munster, Munster, Germany
Aliment Pharmacol Ther 15:677-87. 2001..The roles of active oxygen metabolites and anti-oxidative defenses in aspirin (ASA)-induced gastric damage have been little studied...
- Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivoG Graziani
Dipartimento di Scienza degli Alimenti, , Italy
Gut 54:193-200. 2005..extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo...
- Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in miceJohn Y Kao
Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
Gastroenterology 138:1046-54. 2010..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
- A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infectionM A Poles
Department of Medicine, UCLA School of Medicine, UCLA Center for HIV and Digestive Diseases, Los Angeles, California 90095, USA
J Virol 75:8390-9. 2001..We conclude that, based on these findings, the gastrointestinal mucosa represents a favored target for HIV-1, in part due to its large population of CXCR4(+) CCR5(+) target cells and not to differences in the virus that it contains...
- Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countriesY Yamaoka
Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Microbiol 37:2274-9. 1999..iceA status shows considerable geographic differences, and neither iceA nor combinations of iceA, vacA, and cagA were helpful in predicting the clinical presentation of an H. pylori infection...
- Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?John L Wallace
Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
Physiol Rev 88:1547-65. 2008....
- Runx3 expression in gastrointestinal tract epithelium: resolving the controversyK Ito
Institute of Molecular and Cell Biology, Proteos, Singapore
Oncogene 28:1379-84. 2009..G-poly primarily recognizes the region beyond 234 and hence, is unable to detect Runx3 in this tissue...
- Exfoliation of gastric pit-parietal cells into the gastric lumen associated with a stimulation of isolated rat gastric mucosa in vitro: a morphological study by the application of cryotechniquesFumiyo Aoyama
Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan
Histochem Cell Biol 129:785-93. 2008..In a rat gastric mucosa isolated after stimulation, a number of cells were exfoliated into the gastric lumen of the pit region...
- Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protectionIsao Wada
Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
Biochem Biophys Res Commun 349:611-8. 2006The real mechanism of adaptive cytoprotection in the gastric mucosa is not well established...
- Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?Ebru Turkkan
Department of Internal Medicine, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
J Gastroenterol 44:66-70. 2009..In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia...
- Ghrelin and Helicobacter pylori infectionHiroyuki Osawa
Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
World J Gastroenterol 14:6327-33. 2008..mass index, plasma ghrelin concentration, gastric ghrelin mRNA, and the number of ghrelin producing cells in gastric mucosa are significantly lower in H pylori infected subjects than in H pylori-negative controls...
- Gene expression profiling in human gastric mucosa infected with Helicobacter pyloriVéronique J Hofman
Faculty of Medicine, Inserm ERI 21, Nice Cedex, France
Mod Pathol 20:974-89. 2007..were selected for the presence of chronic active gastritis, in absence of metaplasia and dysplasia of the gastric mucosa. Infected antral and fundic biopsies exhibited distinct transcriptional responses...
- Roles of alpha and beta carbonic anhydrases of Helicobacter pylori in the urease-dependent response to acidity and in colonization of the murine gastric mucosaStéphanie Bury-Moné
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Infect Immun 76:497-509. 2008..mice were infected by SS1 Delta(beta-CA-HP) or by a SS1 double CA mutant, the inflammation scores of the mouse gastric mucosa were strongly reduced. In conclusion, CA contribute to the urease-dependent response to acidity of H...
- Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talkV Sibilia
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milan, Italy
Br J Pharmacol 154:688-97. 2008Ghrelin, a gut-brain peptide, is considered a gastroprotective factor in gastric mucosa. We investigated the role of prostaglandins (PG) and the possible interplay between PGs and nitric oxide (NO) in ghrelin gastroprotection against ..
- Gastric helicobacters in domestic animals and nonhuman primates and their significance for human healthFreddy Haesebrouck
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Clin Microbiol Rev 22:202-23, Table of Contents. 2009Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans...
- Luminal amino acid sensing in the rat gastric mucosaHisayuki Uneyama
Physiology and Nutrition Group, Institute of Life Sciences, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
Am J Physiol Gastrointest Liver Physiol 291:G1163-70. 2006..Altogether, these results strongly suggest the existence of a sensing system for glutamate in the rat gastric mucosa. Thus luminal glutamate would enhance the electrophysiological firing rate of afferent fibers from the vagus ..
- Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide ProductionRupesh Chaturvedi
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Gastroenterology 139:1686-98, 1698.e1-6. 2010..We determined if spermine inhibits iNOS-mediated immunity by reducing L-Arg uptake into macrophages...
- Successful antibiotic treatment of Helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphomasM Raderer
Department of Medicine I, Division of Oncology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Gut 55:616-8. 2006The role of antibiotic treatment in early stage gastric mucosa associated lymphoid tissue (MALT) lymphoma not associated with Helicobacter pylori infection has not been investigated.
- Cellular and molecular mechanisms of gastrointestinal ulcer healingAndrzej S Tarnawski
Department of Medicine, VA Long Beach Healthcare System Long Beach, Long Beach, California 90822, USA
Dig Dis Sci 50:S24-33. 2005..Future directions to accelerate and improve healing include the use of stem cells and tissue engineering...
- Gastroprotection by vitamin C--a heme oxygenase-1-dependent mechanism?Jan C Becker
Department of Medicine B, University of Munster, Munster, Germany
Biochem Biophys Res Commun 312:507-12. 2003....
- Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pyloriHiroyuki Osawa
Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi, Japan 329 0498
J Clin Endocrinol Metab 90:10-6. 2005..pylori-negative subjects. The expression levels of ghrelin mRNA and ghrelin-producing cells in the gastric mucosa were quantified with real-time quantitative RT-PCR and immunohistochemistry, respectively...
- Expression of a 31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary and metastatic gastric carcinomasR Lotan
Department of Tumor Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Int J Cancer 56:474-80. 1994....
- Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infectionIl Ran Hwang
Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 123:1793-803. 2002....
- Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosineMasaru Odashima
First Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
Dig Dis Sci 47:2799-804. 2002..inducible HSP70), which is known as an endogenous cytoprotectant in a wide variety of cells, including rat gastric mucosa in vitro and in vivo...
- Higher gastric cycloxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patientsBor Shyang Sheu
Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan
Clin Cancer Res 9:5245-51. 2003..pylori eradication could reduce COX-2 expression...
- Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretionS P Cole
Department of Medicine, University of California, San Diego, La Jolla 92093, USA
Infect Immun 65:843-6. 1997..Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells...
- Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
Cancer Sci 96:835-43. 2005..pylori strains carrying biologically more active CagA are more virulent than those with less active CagA and are more closely associated with gastric carcinoma...
- Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in JapanMitsushige Sugimoto
First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, 431 3192, Japan
Cancer Epidemiol Biomarkers Prev 15:1929-34. 2006..The aim of this study was to clarify the association of the chymase gene (CMA/B) and ACE polymorphisms with susceptibility to gastric cancer and peptic ulcer...
- SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA proteinHideaki Higashi
Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Science 295:683-6. 2002..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2...
- The spatial orientation of Helicobacter pylori in the gastric mucusSören Schreiber
Institut fur Physiologie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
Proc Natl Acad Sci U S A 101:5024-9. 2004..H. pylori thus uses the gastric mucus pH gradient for chemotactic orientation...
- EMR for early gastric cancer in Korea: a multicenter retrospective studyJae J Kim
Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
Gastrointest Endosc 66:693-700. 2007..EMR has been accepted as a treatment modality for selected cases of early gastric cancer (EGC) in Japan. However, long-term outcomes after EMR for EGC have not been fully documented...
- Eosinophil interactions with Haemonchus contortus larvae in the ovine gastrointestinal tractA Balic
Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Victoria 3010, Australia
Parasite Immunol 28:107-15. 2006..In addition, they also suggest that effective killing by tissue eosinophils may depend on other microenvironmental factors such as intra-epithelial mast cells and IL-4...
- Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cellsSong Ze Ding
Division of Gastroenterology and Hepatology, Department of Medicine, P O Box 800708, Charlottesville, VA 22908 0708, USA
Infect Immun 75:4030-9. 2007..pylori. These results indicate that bacterial factors and the host inflammatory response confer oxidative stress to the gastric epithelium during H. pylori infection that may lead to apoptosis...
- Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cellsJi Hye Seo
Department of Pharmacology and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
Ann N Y Acad Sci 1096:29-36. 2007..PAR-2 agonist peptide augmented H. pylori-induced COX-2 expression in AGS cells. H. pylori induces COX-2 expression, which is mediated by both activation and expression of PAR-2 in gastric epithelial cells...
- The effect of Helicobacter felis and Helicobacter bizzozeronii on the gastric mucosa in Mongolian gerbils: a sequential pathological studyM de Bock
Departments of Pathology, Bacteriology and Avian Diseases, Faculty of Medicine, Ghent University, Belgium
J Comp Pathol 135:226-36. 2006..The mechanism by which H. felis induces PC necrosis and apoptosis remains unclear. The observed flagellar contact and NF-kappaB activation may play an important role in H. felis-associated inflammation...
- DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cellsSuck-Chei Choi
Digestive Disease Research Institute, Wonkwang University School of Medicine, Chonbuk, Korea
World J Gastroenterol 12:4850-8. 2006..CONCLUSION: DA-9601 blocked TNF-alpha-mediated inflammatory signals by potentially modulating the p38 kinase pathway and/or a signal leading to NF-kappaB-dependent pathways in gastric epithelial cells...
- Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasiaWataru Shibata
Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Gastroenterology 138:1022-34.e1-10. 2010..We derived mice with a conditional knockout of IKKbeta in gastric epithelial cells (GECs) and myeloid cells, and examined responses to ionizing radiation (IR) and Helicobacter felis infection...
- Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil proteinO Lefebvre
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, Communaute Urbaine de Strasbourg, France
Science 274:259-62. 1996To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated...
- Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in ratsChun Ying Li
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, South Korea
Alcohol 42:683-7. 2008..These results suggest that the gastroprotective effect of C3G removes the ethanol-induced lipid peroxides and free radicals and that it may offer a potential remedy for the treatment of gastric lesions...
- Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagAManuel R Amieva
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 300:1430-4. 2003..CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions...
- Gastric mucosal defense and cytoprotection: bench to bedsideLoren Laine
Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Gastroenterology 135:41-60. 2008The gastric mucosa maintains structural integrity and function despite continuous exposure to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue...
- Gastroduodenal mucosal defenseAmy Zhu
West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 10:548-54. 2008..This article also summarizes some new findings on the genetics of ulcer formation and the effects of age and gender on mucosal defense and touches on current developments in drugs, including considerations for future therapeutic agents...
- Isolation and identification of Helicobacter spp. from canine and feline gastric mucosaK Jalava
Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, FIN 00014 University of Helsinki, Finland
Appl Environ Microbiol 64:3998-4006. 1998It is known that virtually all healthy adult dogs and cats harbor spiral helicobacters in their gastric mucosa. Three species, Helicobacter felis, Helicobacter bizzozeronii, and Helicobacter salomonis have been isolated in vitro from the ..
- Transthyretin-derived amyloid deposition on the gastric mucosa in domino recipients of familial amyloid polyneuropathy liverYo ichi Takei
Department of Internal Medicine Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto, Japan
Liver Transpl 13:215-8. 2007..In FAP liver recipients, de novo systemic amyloid deposition may begin much sooner than previously supposed. Therefore, careful follow-up of domino recipients of FAP livers is required...
- Target molecules of molecular chaperone (HSP70 family) in injured gastric mucosa in vivoMichiro Otaka
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
Life Sci 84:664-7. 2009..In the present study, gastric mucosal proteins that specifically bind to the HSP70 family (HSC70) were analyzed using HSC70-affinity chromatography...
- Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intakeGeyang Xu
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
Endocrinology 150:3637-44. 2009..mTOR is therefore a gastric fuel sensor whose activity is linked to the regulation of energy intake through ghrelin...
- Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cellsMichiko Tanaka-Shintani
Kobe University School of Medicine, Faculty of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142, Japan
J Gastroenterol 40:345-9. 2005..We examined the distribution of ghrelin-immunoreactive cells in human gastric mucosa. METHODS: We studied the tumor-free mucosa along the lesser curvature in 30 patients with gastric cancer...
- MicroRNA signatures in Helicobacter pylori-infected gastric mucosaKayoko Matsushima
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
Int J Cancer 128:361-70. 2011..microRNA (miRNA), a non-coding RNA that controls gene expression mainly through translational repression, in gastric mucosa infected with Helicobacter pylori. Using endoscopic biopsy specimens, miRNA expression patterns in H...
- Helicobacter pylori colonization of the human gastric epithelium: a bug's first step is a novel target for usBor Shyang Sheu
Department of Internal Medicine and Graduate Institute of Clinical Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan
J Gastroenterol Hepatol 25:26-32. 2010..steps are vital for infection: (i) establishing colonization; (ii) evading host immunity; and (iii) invading gastric mucosa; the last step is what is associated with diverse outcomes...
- Expression of vanilloid receptor-1 in epithelial cells of human antral gastric mucosaStergios Kechagias
Division of Internal Medicine, Department of Medicine and Care, University Hospital, , Sweden
Scand J Gastroenterol 40:775-82. 2005..The aim of the present study was to evaluate the distribution of VR1 immunoreactivity in the normal human gastric mucosa. MATERIALS AND METHODS: Ten volunteers underwent gastroscopy and biopsies were obtained from the corpus and ..
- Helicobacter pylori infection, but not low-dose aspirin, results in a local reduction of the secretory leukocyte protease inhibitor in gastroduodenal mucosaThomas Wex
Department of Gastroenterology, Hepatology and Infectious Diseases, Tongji Medical College of Basic Medical Sciences, Huazhong University of Wuhan, China
Helicobacter 11:31-8. 2006..Therefore, the effect of low-dose aspirin on gastrointestinal SLPI expression was analyzed in the context of H. pylori infection...
- Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the ratGiuseppina Cantarella
Department of Experimental and Clinical Pharmacology, School of Medicine, University of Catania, Italy
Eur J Pharmacol 518:221-6. 2005Here we show the increased hepatocyte growth factor (HGF) and cyclooxygenase-2 (COX-2) expression in gastric mucosa of rats which have developed a reserpine-induced ulcer...
- Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glandsJonathan E Kohler
Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Gastrointest Liver Physiol 299:G170-8. 2010....
- Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?Takahisa Nakayama
Department of Pathology, Shiga University of Medical Science, Otsu, 520 2192 Japan
BMC Cancer 10:311. 2010..The aim of this study was to clarify the extent of overlap of genetic lineages between early and advanced tubular adenocarcinomas (TUBs) of the stomach...
- Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosaArindam Saha
Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
Gut 59:874-81. 2010Helicobacter pylori infection of gastric mucosa causes gastritis and transient hypochlorhydria, which may provoke emergence of a mucosal precancer phenotype; H pylori strains containing a cag pathogenicity island (PAI) augment cancer risk...
- Ghrelin in diseases of the gastric mucosa associated with Helicobacter pylori infectionAnna Zub-Pokrowiecka
2nd Department of General Surgery of Jagiellonian University Medical College, Cracow, Poland
Med Sci Monit 16:CR493-500. 2010Ghrelin is a hormone produced by neuroendocrine cells of gastric mucosa. Its concentration changes in cases of Helicobacter pylori (H...
- Changes in coagulation-fibrinolysis balance in blood mononuclear cells and in gastric mucosa from patients with Helicobacter pylori infectionM Colucci
Department of Biomedical Sciences and Human Oncology, Section of General Pathology, University of Bari, Piazza G Cesare, 11 I 70124 Bari, Italy
Thromb Res 116:471-7. 2005..In this study we investigated the procoagulant-fibrinolytic potential of blood MNC in patients with H. pylori infection. In the same patients we also evaluated the coagulation-fibrinolysis profile in gastric tissue and in plasma...
- Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosaCatherine S Chew
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Sanders R and E Bldg, Rm CB 2803, Augusta, GA, USA
Am J Physiol Gastrointest Liver Physiol 289:G320-31. 2005..aim of this study was to define the pattern of drebrin expression in gland units in the intact rabbit oxyntic gastric mucosa and to initiate approaches to define the functions of this protein in parietal cells...
- Gastroduodenal mucosal defenseArushi deFoneska
Greater Los Angeles Veteran Affairs Healthcare System, WLAVA Medical Center, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90073, USA
Curr Opin Gastroenterol 26:604-10. 2010..We have summarized recent findings related to gastroduodenal mucosal defense as well as factors contributing to defensive failure, highlighting findings that illuminate new pathophysiological mechanisms...
- Heterogeneity of acid secretion induced by carbachol and histamine along the gastric gland axis and its relationship to [Ca2+]iJose Francisco Perez-Zoghbi
Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Am J Physiol Gastrointest Liver Physiol 295:G671-81. 2008..2, both triggered by Ca(2+) release. Maintenance of acid secretion depends on Ca(2+) entry and perhaps membrane fusion...
- Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathwaysChun Mei Zhao
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO 7006, Trondheim, Norway
Endocrinology 149:498-505. 2008..We suggest that there is a remodeling of the neuroendocrine mechanisms that regulate acid secretion in these mutant mice...
- Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacinO Pastoris
Department of Physiological and Pharmacological Sciences, University of Pavia, Piazza Botta 11, 27100, Pavia, Italy
Naunyn Schmiedebergs Arch Pharmacol 378:421-9. 2008..The latter was investigated by using esomeprazole against indomethacin-induced gastric mucosa lesions in rats and assessed by a histomorphometric analysis...
- Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaBH Kim
Dept. of Pharmacology and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
Scand J Gastroenterol 36:706-16. 2001..H. pylori-induced expression of IL-8 and COX-2 was blocked in AGS cells transfected with p50 AS ODN. CONCLUSION: NF-kappaB may play a novel role in expression of IL-8 and COX-2 in H. pylori-induced gastric inflammation...
- Long-term outcomes of gastric mucosa-associated lymphoid tissue lymphomas after Helicobacter pylori eradication therapyShiho Terai
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
Tohoku J Exp Med 214:79-87. 2008..pylori eradication therapy was favorable. A watch and wait strategy may be a reasonable approach for hRD since the majority might be in the process of turning into delayed CR...
- Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing processTamara Regina Calvo
Departamento de Quimica Organica, Instituto de Quimica, Universidade Estadual Paulista UNESP, Araraquara, SP, Brazil
Biol Pharm Bull 30:451-9. 2007..We also established the phytochemical profile of AG with the quantification of total phenolic compounds. These compounds may contribute to the observed antiulcerogenic effects of AG...
- Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of ColombiaM Constanza Camargo
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232 0252, USA
Acta Gastroenterol Latinoam 37:238-45. 2007..pylori therapy, as well as on the histological parameters in the gastric mucosa from subjects from a high gastric cancer risk area...
- Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinomaJoana Gomes
Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
J Histochem Cytochem 57:79-86. 2009..This study evaluated the expression of ppGalNAc-T6 in human gastric mucosa, intestinal metaplasia, and gastric carcinomas...
- Progression of atrophic gastritis and intestinal metaplasia drives Helicobacter pylori out of the gastric mucosaHae Yeon Kang
Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
Dig Dis Sci 51:2310-5. 2006..These results suggest that anti-H. pylori IgG positivity with all negative invasive H. pylori tests represents past infection with H. pylori rather than a false negative, especially in the case of dysplasia and gastric cancer...
- Isolation, culture and adenoviral transduction of parietal cells from mouse gastric mucosaBriony L Gliddon
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia
Biomed Mater 3:034117. 2008....
- Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS miceChung Wei Lee
Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cancer Res 68:3540-8. 2008..pylori eradication prevented gastric cancer to the greatest extent when antibiotics are given at an early point of infection, but that eradication therapy given at a later time point delayed the development of severe dysplastic lesions...
- The role of persistence in Helicobacter pylori pathogenesisDawn A Israel
Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0252, USA
Curr Opin Gastroenterol 22:3-7. 2006..pylori-host interactions will not only improve targeted diagnostic and therapeutic modalities, but may also provide insights into other diseases that arise within the context of chronic pathogen infection...
- Background submucosal cysts in early gastric cancer cases have unique clinicopathologic features suggestive of postgastritis and significant smoking associationMasaaki Ichinoe
Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
Am J Clin Pathol 128:746-52. 2007..The Brinkman index was also significantly higher. Cases of gastric cancer with SMC show characteristic clinicopathologic features, and SMC formation may be caused by gastritis and influenced by smoking...
- CagA in Barrett's oesophagus in Colombia, a country with a high prevalence of gastric cancerM Kudo
Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
J Clin Pathol 58:259-62. 2005..These data illustrate how consistent corpus inflammation reduces acid secretion, which prevents Barrett's oesophagus among those with abnormal gastro-oesophageal reflux barriers...
- [Chronic gastritis: last decade's achievements and problems]S I Pimanov
Klin Med (Mosk) 83:54-8. 2005..to statandardize international research and perform more objective diagnostics of pathological changes in the gastric mucosa. Studies carried out in recent years have established that morphological manifestations of chronic gastritis ..
- Effects of Helicobacter pylori Infection on gastric mucin expressionHyung Min Kang
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi Do, Korea
J Clin Gastroenterol 42:29-35. 2008..pylori-associated gastroduodenal diseases. In addition, MUC5AC and MUC6 expressional changes were investigated before and after H. pylori eradication...
- [Biochemical and immunological criteria for evaluation of gastric mucosa in tumor and non-tumor pathology]M N Uspenskiĭ
Vopr Onkol 53:304-10. 2007
- Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pyloriBernd Schmausser
Institut fur Pathologie, Universitat Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
Int J Med Microbiol 295:179-85. 2005..pylori. As H. pylori can induce gastric carcinoma-promoting factors, such as IL-8, via epithelial TLR expression, TLR expression by gastric carcinoma cells may have a dangerous potential...
- Influence of bile reflux and Helicobacter pylori infection on gastritis in the remnant gastric mucosa after distal gastrectomyHisanori Abe
Arita Gastro-Intestinal Hospital, 1-2-6 Maki, Oita, 870-0924, Japan
J Gastroenterol 40:563-9. 2005..pylori infection and with a lower degree of inflammatory cellular infiltration...
- Fluorescence in situ hybridisation analysis of chromosomal aberrations in gastric tissue: the potential involvement of Helicobacter pyloriL Williams
Neath Port Talbot Hospital, Baglan, UK
Br J Cancer 92:1759-66. 2005..Aneuploidy of chromosomes 4, 8, 20 and 17(p53) was detected in histologically normal gastric mucosa, as well as in gastritis, intestinal metaplasia, dysplasia and cancer samples...
- Regression of EI2-stage low-grade gastric MALT-lymphoma after H. pylori eradicationGiovanni Cammarota
Department of Internal Medicine and Gastroenterology, Catholic University of Rome, Italy
Hepatogastroenterology 52:975-7. 2005....
- Topographic expression of MUC5AC and MUC6 in the gastric mucosa infected by Helicobacter pylori and in associated diseasesTerezinha Marques
Department of Pathology, Medical School, Federal University of Minas Gerais UFMG, Brazil
Pathol Res Pract 201:665-72. 2005..The topographic over- and under-expression of mucins in H. pylori-associated gastritis and peptic disease suggest a role for these mucins in the pathogenesis of H. pylori infection and associated diseases...
- Gastric angiogenesis and Helicobacter pylori infectionI D Pousa
Service of Gastroenterology, Hospital Universitario de la Princesa, Madrid, Spain
Rev Esp Enferm Dig 98:527-41. 2006..or indirectly damages endothelial cells, which induces a number of changes in the microvasculature of the gastric mucosa. In H...
- Pathological disorders of the gastric mucosa surrounding carcinomas and primary lymphomasJ Arista-Nasr
Department of Pathology, , , Mexico
Am J Gastroenterol 96:1746-50. 2001..study is to determine the frequency and characteristics of epithelial and lymphoid tissue disorders of the gastric mucosa surrounding primary carcinomas and lymphomas...
- Prevalence of H pylori associated "high risk gastritis" for development of gastric cancer in patients with normal endoscopic findingsAndreas Leodolter
Department of Gastroenterology and Hepatology, Otto von Guericke University, Leipziger Street 44, Magdeburg D 39120, Germany
World J Gastroenterol 12:5509-12. 2006..To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any significant abnormal findings during upper-GI endoscopy...
- Gastric precancerous changes: carcinogenesis, clinical behaviour immunophenotype study and surveillanceG Testino
Unit of Hepatogastroenterology, Department of Organ Transplantation, S Martino Hospital, Genoa, Italy
Panminerva Med 48:109-18. 2006..The choice to address the patients to surgical intervention could be made not only on the basis of histochemical techniques, but also with the help of immunohistochemical evaluations...
- [Histopathological study of gastric polyps. A report of 65 cases]Faten Farah Klibi
Tunis Med 84:611-6. 2006..Other lesions were found within the polyps or into the surrounding gastric mucosa, such as intestinal metaplasia and Helicobacter Pylori gastritis...
- Is Mongolian gerbil really adequate host animal for study of Helicobacter pylori infection-induced gastritis and cancer?Michiro Otaka
Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, Japan
Biochem Biophys Res Commun 347:297-300. 2006..this study was to evaluate the induction ability of heat shock protein (HSP70) and protective ability in the gastric mucosa of MG comparing with those of Sprague-Dawley (SD) rats, since HSP70 is a key molecule known to be involved in ..
- Clinical significance and outcome of gastric mucosal erosions: a long-term follow-up studyK T Toljamo
Department of Internal Medicine, Division of Gastroenterology, University of Oulu, Finland
Dig Dis Sci 51:543-7. 2006..We conclude that a significant proportion of gastric erosions are chronic or recurrent but mostly without serious complications. However, H. pylori-positive patients with erosions have significant risk to develop a peptic ulcer...
- Increased epithelial and serum expression of macrophage migration inhibitory factor (MIF) in gastric cancer: potential role of MIF in gastric carcinogenesisX-X He
Department of Gastroenterology, The Second Affiliated Hospital of Guanzhou Medical College, Guangzhou, China
Gut 55:797-802. 2006..MATERIALS AND METHODS: Patients with a normal gastric mucosa, Helicobacter pylori infected gastritis, intestinal metaplasia, and gastric adenocarcinoma were included...
- The saga of gastric corpus atrophyP Correa
Pathologica 97:319-22. 2005
- Efficacy of Helicobacter pylori eradication on the chronic mucosal inflammation of the remnant stomach after distal gastrectomy for early gastric cancerN Onoda
Dept of Oncology, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Japan
J Exp Clin Cancer Res 24:515-21. 2005..Eradication therapy could be performed safely and resulted in a significant improvement in inflammation and atrophy of the mucosal layer in the remnant stomach after early gastric cancer surgery...
- Expression of Lewis antigens and their precursors in gastric mucosa: relationship with Helicobacter pylori infection and gastric carcinogenesisH S Lee
Department of Pathology, Seoul National University College of Medicine, Korea
J Pathol 209:88-94. 2006..05). The babA2 genotype was more frequent in gastric mucosa from the gastric cancer patients than in gastric biopsy specimens from routine gastroscopy (p = 0.009)...
- Interleukin-10 (-819 C/T) and TNF-A (-308 G/A) as risk factors for H. pylori-associated gastric MALT-lymphomaStephan Hellmig
Dig Dis Sci 53:2007-8. 2008
- [Helicobacter pylori 2006: how to test, when to treat]B van der Weg
Fachbereich Gastroenterologie/Hepatologie, Kantonsspital St. Gallen
Schweiz Rundsch Med Prax 95:1413-8. 2006..pylori eradication consists of a proton pump inhibitor (PPI) and two antibiotics, though it isn't always successful. After a second treatment failure, a H. pylori culture is indicated to asses the antibiotic resistances...
- Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotypeMauro Cassaro
Department of Diagnostic Medicine and Special Therapies, University of Padova, II Pathology Unit, Padova, Italy
J Clin Pathol 60:615-21. 2007....
- [Gastric pseudolipomatosis: an under-diagnosed entity]C Alvarez-Alvarez
Gastroenterol Hepatol 28:659. 2005
- Interleukin-10 (-819 C/T) and tumor necrosis factor-alpha (-308 G/A) gene variants influence gastritis and lymphoid follicle developmentB R Achyut
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Dig Dis Sci 53:622-9. 2008..pylori infection than without (58.5% versus 22.2%; p = 0.064). IL-10 -819 T and TNF-alpha -308 A alleles may increase risk of gastritis and lymphoid follicle formation...
- Regular arrangement of collecting venules (RAC): a characteristic endoscopic feature of Helicobacter pylori-negative normal stomach and its relationship with esophago-gastric adenocarcinomaKazuyoshi Yagi
Department of Internal Medicine, Niigata Prefectural Yoshida Hospital, Yoshida-machi, Niigata, 959-0242, Japan
J Gastroenterol 40:443-52. 2005
- [Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]Y Keto
Department of Applied Pharmacology, Kyoto Pharmaceutical University, 5 Misasagi Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan
Nippon Yakurigaku Zasshi 118:259-68. 2001..pylori infection with drug therapy can prevent severe gastric mucosal changes, to include adenocarcinomas, in M gerbils...
- REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIYoshio Yamaoka; Fiscal Year: 2010..Our previous results are based on analysis of the whole gastric mucosa. Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric ..
- UREASE AND GENE EXPRESSION OF HELICOBACTER PYLORIHARRY MOBLEY; Fiscal Year: 2007..This species, whose niche is highly restricted to the gastric mucosa of humans, has adopted a strategy of survival that includes synthesis of urease as its most abundant cellular ..
- GASTRIC H+ ION TRANSPORT-CELLULAR CONTROL MECHANSIMSCATHERINE CHEW; Fiscal Year: 2005..paracrines and growth factors interact to control hydrochloric acid secretion by parietal cells in the gastric mucosa. Gastroesophageal reflux and peptic ulcer disease are widespread clinical problems that result from or are ..
- Structure-Function Studies of the Proton-Gated Urea Channel from H. PyloriHartmut Luecke; Fiscal Year: 2009Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
- Structure-Function Studies of the Proton-Gated Urea Channel from H. PyloriHartmut Luecke; Fiscal Year: 2009Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
- Structure-Function Studies of the Proton-Gated Urea Channel from H. PyloriHartmut Luecke; Fiscal Year: 2010Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
- Acetone metabolism in Helicobacter pyloriTimothy Hoover; Fiscal Year: 2004Helicobacter pylori is a major human pathogen that colonizes the gastric mucosa, leading to gastric inflammation that can progress to chronic gastritis, peptic ulcer, gastric cancer or mucosal-associated lymphoma. The ability of H...
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL TRENT; Fiscal Year: 2006..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
- UREASE AND GENE EXPRESSION OF HELICOBACTER PYLORIHARRY MOBLEY; Fiscal Year: 2003..This species, whose niche is highly restricted to the gastric mucosa of humans, has adopted a strategy of survival that includes synthesis of urease as its most abundant cellular ..
- Helicobacter pylori: Tactic Responses and Persistence in the Gastric MucosaPAUL STOKES HOFFMAN; Fiscal Year: 2010....
- Oxidative Injury to Gastric Epithelial Cells by H. pyloriSheila E Crowe; Fiscal Year: 2010..Phagocytic leukocytes recruited to the gastric mucosa during infection become activated, generating reactive oxygen species (ROS) that alter gastric epithelial cell ..
- Oxidative Injury to Gastric Epithelial Cells by H. pyloriSheila Crowe; Fiscal Year: 2009..Phagocytic leukocytes recruited to the gastric mucosa during infection become activated, generating reactive oxygen species (ROS) that alter gastric epithelial cell ..
- H.pylori arginase modulation of ulcers and cancerDavid McGee; Fiscal Year: 2007..Polyamines (produced from ornithine) and arginase are elevated in the gastric mucosa of gastric cancer patients. Preliminary data demonstrate arginase is critical for H...
- Helicobacter pylori: Tactic Responses and Persistence in the Gastric MucosaPaul Hoffman; Fiscal Year: 2009....
- Helicobacter pylori: Tactic Responses and Persistence in the Gastric MucosaPaul Hoffman; Fiscal Year: 2007..Understanding the fundamental mechanisms associated with acid survival and gastric colonization underpins all eradicative strategies from vaccines to novel therapeutics against a pathogen that infects half of the world's population. ..
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL TRENT; Fiscal Year: 2009..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL TRENT; Fiscal Year: 2007..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL STEPHEN TRENT; Fiscal Year: 2010
- Bacterial and Chemical Carcinogens in Gastric OncogenesisAndre Dubois; Fiscal Year: 2009..H. pylori persists in the gastric mucosa of >50% of humans worldwide for the life of the host, despite intense immune and inflammatory responses, ..
- H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVESDouglas Berg; Fiscal Year: 2003..Helicobacter pylori (Hp), one of the most genetically diverse of bacterial species, chronically infects the gastric mucosa of more than half of all persons world wide...
- Nickel Metabolism in Helicobacter pyloriRobert Maier; Fiscal Year: 2006Helicobacter pyori is a spiral bacterium that colonizes the gastric mucosa of humans, leading to a variety of gastric diseases that include peptic ulcers, chronic gastritis, mucosal-associated lymphomas, and adenocarcinomas of the lower ..