gastric mucosa

Summary

Summary: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.

Top Publications

  1. ncbi Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
  2. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
  3. pmc Endoscopic mucosal resection for treatment of early gastric cancer
    H Ono
    Department of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Gut 48:225-9. 2001
  4. ncbi Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats
    S Q Wasman
    Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Teknologi Malaysia, 81310, UTM Skudai, Johor, Malaysia
    Indian J Exp Biol 49:767-72. 2011
  5. pmc Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia
    Isabelle C Arnold
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Gastroenterology 140:199-209. 2011
  6. ncbi Gastric mucosal defense and cytoprotection: bench to bedside
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 135:41-60. 2008
  7. ncbi What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori
    Steffen Backert
    University College Dublin, School of Biomolecular and Biomedical Sciences, Belfield Campus, Dublin 4, Ireland
    Trends Microbiol 18:479-86. 2010
  8. ncbi Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response
    Bin Xiao
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, No 30 Gaotanyan Street, Chongqing, China
    J Infect Dis 200:916-25. 2009
  9. ncbi Control of gut differentiation and intestinal-type gastric carcinogenesis
    Yasuhito Yuasa
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Cancer 3:592-600. 2003
  10. ncbi Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer
    Shiro Oka
    Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 64:877-83. 2006

Research Grants

Detail Information

Publications322 found, 100 shown here

  1. ncbi Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
    ....
  2. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  3. pmc Endoscopic mucosal resection for treatment of early gastric cancer
    H Ono
    Department of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Gut 48:225-9. 2001
    ..Bleeding and perforation (5%) were two major complications of EMR but there were no treatment related deaths. CONCLUSION: In our experience, EMR allows us to perform less invasive treatment without sacrificing the possibility of cure...
  4. ncbi Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats
    S Q Wasman
    Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Teknologi Malaysia, 81310, UTM Skudai, Johor, Malaysia
    Indian J Exp Biol 49:767-72. 2011
    ..65. Results of this study showed that pretreatment with ethonolic extract of A. paniculata ethanolic provided significant protection against gastric ulcer by regulating of pH, mucous production and antioxidant property...
  5. pmc Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia
    Isabelle C Arnold
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Gastroenterology 140:199-209. 2011
    ..This study aims to elucidate the differential susceptibility to H pylori that is found both across and within populations...
  6. ncbi Gastric mucosal defense and cytoprotection: bench to bedside
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 135:41-60. 2008
    The gastric mucosa maintains structural integrity and function despite continuous exposure to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue...
  7. ncbi What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori
    Steffen Backert
    University College Dublin, School of Biomolecular and Biomedical Sciences, Belfield Campus, Dublin 4, Ireland
    Trends Microbiol 18:479-86. 2010
    ..Here we discuss the pros and cons of the multiple signaling activities in the induction of proinflammatory responses and associated problems, and give suggestions for finding ways out of this dilemma...
  8. ncbi Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response
    Bin Xiao
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, No 30 Gaotanyan Street, Chongqing, China
    J Infect Dis 200:916-25. 2009
    ..H. pylori is a major human pathogenic bacterium in gastric mucosa. To date, the role of miRNAs in response to H. pylori infection has not been explored.
  9. ncbi Control of gut differentiation and intestinal-type gastric carcinogenesis
    Yasuhito Yuasa
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Cancer 3:592-600. 2003
    ..Inappropriate activation of intestine-specific transcription factors could contribute to the occurrence of the intestinal-type cancer of the stomach...
  10. ncbi Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer
    Shiro Oka
    Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 64:877-83. 2006
    ..In EMR of early gastric cancer (EGC), en bloc resection reduces the risk of residual cancer. Endoscopic submucosal dissection (ESD) now allows en bloc resection of large EGCs...
  11. ncbi Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats
    Kazuko Shichijo
    Department of Molecular Pathology and Radiation Biophysics, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Pathology, Nagasaki Medical Center, Japan
    Dig Dis Sci 48:340-8. 2003
    ..Our results indicate that overexpression of heat shock protein 70 in the stomach seems to protect against gastric ulcers through its cytoprotective effects on gastric mucosa by increasing mucosal blood flow.
  12. ncbi Antioxidant properties of natural compounds used in popular medicine for gastric ulcers
    M G Repetto
    Laboratorio de Estrés Oxidativo en Patologías Humanas, Catedra de Quimica General e Inorganica, Departamento de Química Analítica y Fisicoquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Braz J Med Biol Res 35:523-34. 2002
    ..In this review article, we shall consider the role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol...
  13. ncbi Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
    K Robinson
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
    Gut 57:1375-85. 2008
    ..To address the hypothesis that the human acquired immune response to H. pylori influences pathogenesis, we characterised the gastric T helper (Th) and regulatory T cell (Treg) response of infected patients...
  14. pmc Gastric epithelial stem cells
    Jason C Mills
    Division of Gastroenterology, Department of Medicine, Pathology and Immunology, and Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 140:412-24. 2011
    ..We review the cytologic, molecular, functional, and developmental properties of gastric epithelial stem cells...
  15. pmc Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa
    Thomas W Cullen
    Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, Texas, United States of America
    PLoS Pathog 7:e1002454. 2011
    ..Furthermore, lpxE/F mutants were unable to colonize the gastric mucosa of C57BL/6J and C57BL/6J tlr4 -/- mice when compared to wild type H. pylori...
  16. ncbi CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk
    Mitsuru Kaise
    Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Helicobacter 13:35-41. 2008
    ..We investigated this linkage in noncancerous gastric mucosa infected with H. pylori.
  17. ncbi Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:10709-15. 2005
    ..In summary, we report for the first time H. pylori-induced gastric intraepithelial neoplasia in a wild-type mouse model and show no additive effect of high-salt ingestion on tumor progression...
  18. pmc IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
    Shui Ping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    Cancer Res 71:4247-59. 2011
    ..It is upregulated in the gastric mucosa by chronic Helicobacter infection; however, whether it plays a positive or negative role in inflammation-..
  19. ncbi Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
    N Murata-Kamiya
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 26:4617-26. 2007
    ..Intestinal metaplasia is a precancerous lesion of the stomach characterized by transdifferentiation of the gastric mucosa to an intestinal phenotype. The H...
  20. ncbi Characteristics of metachronous multiple early gastric cancers after endoscopic mucosal resection
    J Nasu
    Dept of Internal Medicine, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan
    Endoscopy 37:990-3. 2005
    ..The incidence and characteristics of metachronous multiple gastric cancers were investigated in a retrospective study in patients with early gastric cancer after EMR treatment...
  21. ncbi Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells
    Zhen Liu
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Third Military Medical University, Chongqing 400038, China
    Microbes Infect 12:854-63. 2010
    Helicobacter pylori (H. pylori) is a major human pathogenic bacterium in gastric mucosa. However, the regulatory mechanism of H. pylori-induced immune response is not clear...
  22. ncbi Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
    Marina Aspholm-Hurtig
    Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 305:519-22. 2004
    ....
  23. ncbi Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa
    Nicole Wittschier
    University of Munster, Institute for Pharmaceutical Biology and Phytochemistry, Hittorfstrasse 56, D 48149 Munster, Germany
    J Ethnopharmacol 125:218-23. 2009
    ..Additionally the influence of Glycyrrhiza glabra secondary compounds on the bacterial adhesion of Porphyromonas gingivalis, a major pathogen for induction of periodontal inflammations was to be investigated...
  24. pmc Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells
    Susan Kenny
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, UK
    Am J Physiol Gastrointest Liver Physiol 295:G431-41. 2008
    ....
  25. pmc Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa
    Anna Lundgren
    Department of Medical Microbiology and Immunology, Goteborg University, 40530 Goteborg, Sweden
    Infect Immun 73:5612-9. 2005
    ..In conclusion, these results suggest that H. pylori-specific CD4(+) T cells preferentially home to and accumulate in the infected stomach and that L-selectin and CCR4/MDC are important for this recruitment...
  26. pmc Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shinjuku ku, Tokyo, Japan
    PLoS ONE 7:e47396. 2012
    ..To investigate the molecular pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the miRNA expression profile was analyzed...
  27. ncbi Apical Golgi localization of N,N'-diacetyllactosediamine synthase, beta4GalNAc-T3, is responsible for LacdiNAc expression on gastric mucosa
    Yuzuru Ikehara
    Glycostructure Analysis Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory Central 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Glycobiology 16:777-85. 2006
    ..Though LacdiNAc has not been found in the gastric mucosa, a large amount of transcript was detected in our previous study...
  28. ncbi Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats
    Wei Zhao
    Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Acta Biochim Biophys Sin (Shanghai) 41:301-8. 2009
    ..Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway...
  29. ncbi Host-bacterial interactions in Helicobacter pylori infection
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 134:306-23. 2008
    ..pylori are spiral-shaped gram-negative bacteria with polar flagella that live near the surface of the human gastric mucosa. They have evolved intricate mechanisms to avoid the bactericidal acid in the gastric lumen and to survive ..
  30. pmc Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)
    John L Wallace
    Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Br J Pharmacol 159:1236-46. 2010
    ..We evaluated the gastrointestinal safety and anti-inflammatory efficacy of a novel hydrogen sulphide-releasing derivative of naproxen, ATB-346 [2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester]...
  31. ncbi Redox biology and gastric carcinogenesis: the role of Helicobacter pylori
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 16:1-7. 2011
    ..Understanding the molecular mechanism of H. pylori-induced carcinogenesis is important for developing new strategies against gastric cancer...
  32. ncbi Comparison between magnifying endoscopy and histological, culture and urease test findings from the gastric mucosa of the corpus
    K Yagi
    Department of Internal Medicine, Niigata Prefectural Yoshida Hospital, Japan
    Endoscopy 34:376-81. 2002
    ..In a previous study, the endoscopic features and a magnified view of the gastric mucosa of the corpus of H. pylori-negative normal stomach were described...
  33. ncbi Topographic differences in gastric micromucosal patterns observed by magnifying endoscopy with narrow band imaging
    Masashi Kawamura
    Department of Gastroenterology, JR Sendai Hospital, Miyagi, Japan
    J Gastroenterol Hepatol 26:477-83. 2011
    ..The aim of this study was to investigate the differences in distributions of gastric micromucosal structures observed by magnifying narrow band imaging (NBI) endoscopy among patients with different H. pylori-associated diseases...
  34. ncbi IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa
    Roberta Caruso
    Department of Internal Medicine and Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, University Tor Vergata of Rome, Rome, Italy
    Eur J Immunol 38:470-8. 2008
    Helicobacter pylori (Hp) infection is associated with a marked infiltration of the gastric mucosa by inflammatory cells...
  35. ncbi Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?
    John L Wallace
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    Physiol Rev 88:1547-65. 2008
    ....
  36. ncbi Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute and University of Queensland, Mater Misericordiae Hospitals, Brisbane, Australia
    Gastroenterology 133:1210-8. 2007
    The MUC1 mucin is expressed on the cell surface of epithelial cells lining the gastric mucosa. Epidemiologic studies suggest that functional allelic variations in the MUC1 gene may play a role in human susceptibility to Helicobacter ..
  37. pmc Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health
    Freddy Haesebrouck
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Clin Microbiol Rev 22:202-23, Table of Contents. 2009
    Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans...
  38. pmc Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 300:1430-4. 2003
    ..CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions...
  39. ncbi Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa
    F Luzza
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Catanzaro, Italy
    J Immunol 165:5332-7. 2000
    ..inhibition of IL-8 secretion, indicating that IL-17 contributes to enhance IL-8 in the HP-colonized gastric mucosa. Consistently, stimulation of MKN 28 cells, a gastric epithelial cell line, with IL-17 increased IL-8 ..
  40. ncbi Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication
    Francesco Perri
    Department of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Am J Gastroenterol 102:1361-71. 2007
    ..Gene promoter methylation is an epigenetic event leading to gene silencing. This mechanism is particularly relevant in cancer since it can interfere with the activity of specific "suppressor" genes...
  41. ncbi MicroRNA signatures in Helicobacter pylori-infected gastric mucosa
    Kayoko Matsushima
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
    Int J Cancer 128:361-70. 2011
    ..microRNA (miRNA), a non-coding RNA that controls gene expression mainly through translational repression, in gastric mucosa infected with Helicobacter pylori. Using endoscopic biopsy specimens, miRNA expression patterns in H...
  42. pmc Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    John Y Kao
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
    Gastroenterology 138:1046-54. 2010
    ..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
  43. pmc MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS Pathog 5:e1000617. 2009
    ..pylori infected mice. Thus, MUC1 protects the epithelium from non-MUC1 binding bacteria by inhibiting adhesion to the cell surface by steric hindrance, and from MUC1-binding bacteria by acting as a releasable decoy...
  44. pmc Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells
    Jinxiong Wei
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 139:1333-43. 2010
    ..These bacteria colonize a significant part of the world's population. We investigated the molecular mechanisms of p53 regulation in H pylori-infected cells...
  45. ncbi SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Science 295:683-6. 2002
    ..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2...
  46. pmc Molecular analysis of the bacterial microbiota in the human stomach
    Elisabeth M Bik
    Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild Science Building, 299 Campus Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:732-7. 2006
    ..We characterized bacterial diversity within the human gastric mucosa by using a small subunit 16S rDNA clone library approach and analyzed 1,833 sequences generated by broad-range ..
  47. ncbi Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization
    Tomokazu Mizuno
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 11:6305-11. 2005
    ..To determine the role of interleukin (IL)-17 in gastric ulcerogenesis...
  48. ncbi SPARC is associated with gastric cancer progression and poor survival of patients
    Zhong sheng Zhao
    Departments of Pathology and Surgery, Zhejiang Provincal People s Hospital, Hangzhou, Zhejiang, People s Republic of China
    Clin Cancer Res 16:260-8. 2010
    ..The present study investigated the clinical significance of secreted protein, acidic and rich in cysteine (SPARC), in the development and progression of gastric cancer...
  49. ncbi Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice
    L E Smythies
    Department of Medicine, Pathology, and Comparative Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 165:1022-9. 2000
    ..pylori infection and demonstrate that up-regulated production of IFN-gamma, in the absence of the opposing effects of IL-4 (and possibly IL-10), plays a pivotal role in promoting H. pylori-induced mucosal inflammation...
  50. ncbi Correlation between narrow band imaging and nonneoplastic gastric pathology: a pilot feasibility trial
    Ajay Bansal
    Department of Gastroenterology and Pathology, University of Kansas School of Medicine, Kansas City, Missouri, USA
    Gastrointest Endosc 67:210-6. 2008
    ..A novel narrow band imaging (NBI) system is able to visualize the mucosal and vascular network in the GI tract...
  51. ncbi Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Gastrointest Endosc 70:246-53. 2009
    ..Magnifying narrow-band imaging (NBI) endoscopy clearly visualizes superficial gastric mucosal patterns and capillary patterns...
  52. ncbi Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats
    V Lakshmi
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, U P, India
    Phytomedicine 17:569-74. 2010
    ..This study is the first of its kind to show significant anti-secretory effect of gedunin and photogedunin. Therefore it could act as a potent therapeutic agent against peptic ulcer disease...
  53. ncbi Adherence properties of Helicobacter pylori: impact on pathogenesis and adaptation to the host
    Stefan Odenbreit
    Max von Pettenkofer Institute for Hygiene und Medical Microbiology, Ludwig Maximilians University, Pettenkoferstr 9a, D 80336 Munich, Germany
    Int J Med Microbiol 295:317-24. 2005
    The adherence of the human gastric pathogen Helicobacter pylori to the gastric mucosa is widely assumed to play a substantial role in initial colonization and long-term persistence in the human stomach...
  54. ncbi Technical feasibility of endoscopic submucosal dissection for early gastric cancer in patients taking anti-coagulants or anti-platelet agents
    S Ono
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo, Tokyo 113 8655, Japan
    Dig Liver Dis 41:725-8. 2009
    ..Anti-coagulants and anti-platelet agents are widely used, especially in elderly patients, to prevent thromboembolic disease. However, the feasibility of endoscopic submucosal dissection for such patients has not been investigated...
  55. ncbi Dexamethasone inhibits basic fibroblast growth factor-stimulated gastric epithelial cell proliferation
    Jiing Chyuan Luo
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Biochem Pharmacol 76:841-9. 2008
    ....
  56. pmc Epstein Barr virus and Helicobacter pylori co-infection are positively associated with severe gastritis in pediatric patients
    María G Cárdenas-Mondragón
    Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias UIMEIP, Hospital de Pediatria, CMN Siglo XXI, Instituto Mexicano del Seguro Social IMSS, Mexico City, Mexico
    PLoS ONE 8:e62850. 2013
    H. pylori infection is acquired during childhood and causes a chronic inflammatory response in the gastric mucosa, which is considered the main risk factor to acquire gastric cancer (GC) later in life...
  57. ncbi Endoscopic submucosal dissection is an effective and safe therapy for early gastric neoplasms: a multicenter feasible study
    Takafumi Sugimoto
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Gastroenterol 46:124-9. 2012
    ..The drawback of ESD is its technical difficulty and, consequently, its higher rate of complication. In this multicenter study, we investigated the therapeutic outcomes of ESD in consecutive patients...
  58. ncbi A multicenter validation of an endoscopic classification with narrow band imaging for gastric precancerous and cancerous lesions
    P Pimentel-Nunes
    Department of Gastroenterology, Portuguese Oncology Institute of Porto, Rua Dr Bernardino de Almeida, Porto, Portugal
    Endoscopy 44:236-46. 2012
    ..The aim of the current study was to describe and estimate the accuracy and reliability of a simplified classification system for NBI in the diagnosis of gastric lesions...
  59. ncbi Effects of Helicobacter pylori eradication on early stage gastric mucosa-associated lymphoid tissue lymphoma
    Angelo Zullo
    Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy
    Clin Gastroenterol Hepatol 8:105-10. 2010
    ..We assessed the long-term remission and relapse rates of early stage MALT lymphoma in patients treated only by H pylori eradication and identified factors that might predict outcome...
  60. ncbi Gastric and intestinal claudin expression at the invasive front of gastric carcinoma
    Yoshiko Matsuda
    Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Sci 98:1014-9. 2007
    ..intestinal mucins, the tight junction proteins called claudins can be used to determine the differentiation of gastric mucosa. We investigated the expression of claudins in gastric cancer and proposed a new claudin-based gastric cancer ..
  61. ncbi High-level expression of S100A4 correlates with lymph node metastasis and poor prognosis in patients with gastric cancer
    Yuan Yu Wang
    Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    Ann Surg Oncol 17:89-97. 2010
    ..The present study investigated the clinical significance of S100 calcium binding protein A4 in the development, progression, and metastasis of gastric cancer...
  62. ncbi Regulation of cathepsin X overexpression in H. pylori-infected gastric epithelial cells and macrophages
    Sabine Krueger
    Institute of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Pathol 217:581-8. 2009
    Cathepsin X (CTSX) is strongly up-regulated in Helicobacter pylori-infected gastric mucosa and intestinal-type gastric cancer...
  63. ncbi In vivo effects of TGFbeta1 on the growth of gastric epithelium in suckling rats
    Eunice Ribeiro de Andrade Sá
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Av Prof Lineu Prestes 1524 ICB I, University of Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Regul Pept 146:293-302. 2008
    ..we observed the progressive increase of active TGFbeta1 while TbetaRII-receptor remained constant in the gastric mucosa. By immunohistochemistry, we showed Smad2/3 increase at 60 min (p<0...
  64. ncbi Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer
    Xiaoying Guo
    Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    J Biol Chem 283:19864-71. 2008
    ..mice) was recently constructed by simultaneous activation of prostaglandin (PG) E2 and Wnt signaling in the gastric mucosa. Because both the PGE2 and Wnt pathways play a role in human gastric tumorigenesis, the Gan mouse model ..
  65. ncbi Opposite effects of fasting on TGF-beta3 and TbetaRI distribution in the gastric mucosa of suckling and early weanling rats
    Daniela Ogias
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 26:224-9. 2010
    ....
  66. ncbi The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis
    Theodoros Rokkas
    Gastroenterology Clinic, Henry Dunant Hospital, Athens, Greece
    Helicobacter 12:32-8. 2007
    ..In this process the gastric mucosa evolves through the stages of acute gastritis, chronic gastritis, gastric atrophy (GA), and intestinal ..
  67. ncbi Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    J Biol Chem 284:3058-68. 2009
    ....
  68. ncbi Long-term clinical outcome of helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma is comparable to that of h. pylori-positive lymphoma
    Su Jin Chung
    Seoul National University Hospital Healthcare System, Yeoksam dong, Gangnam Gu, Yongon Dong, Chongno Gu, Seoul, Republic of Korea
    J Clin Gastroenterol 43:312-7. 2009
    Little is still known regarding the clinical features and prognosis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma without Helicobacter pylori (H. pylori) infection.
  69. ncbi High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk
    Takao Maekita
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
    Clin Cancer Res 12:989-95. 2006
    ..Here, we analyzed the effect of H. pylori infection on the quantity of methylated DNA molecules in noncancerous gastric mucosae and examined its association with gastric cancer risk...
  70. pmc Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives
    F Halter
    VA Medical Center, Long Beach, California 90822, USA
    Gut 49:443-53. 2001
    ..there is increasing evidence that upregulation of COX-2 mRNA and protein occurs during exposure of the gastric mucosa to noxious agents or to ischaemia-reperfusion...
  71. ncbi Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult rats
    Daniela Ogias
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Physiol Gastrointest Liver Physiol 298:G117-25. 2010
    ..We suggest that this mechanism could ultimately increase cell proliferation and allow regular gastric growth during adverse nutritional conditions...
  72. pmc Quiescent gastric stem cells maintain the adult Drosophila stomach
    Marie Strand
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:17696-701. 2011
    ..Characterization of the GSSC lineage in Drosophila, with striking similarities to mammals, will advance the study of both homeostatic and pathogenic processes in the stomach...
  73. pmc Acute toxicity and gastroprotection studies with a newly synthesized steroid
    Kamal A Ketuly
    Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e59296. 2013
    ..The purpose of the present study was to evaluate the effect of a synthetic steroid, (20S)-22-acetoxymethyl-6β-methoxy-3α,5-dihydro-3'H-cyclopropa[3α,5]-5α-pregnane (AMDCP), on ethanol-induced gastric mucosa injuries in rats.
  74. pmc Local cytokine response in Helicobacter pylori-infected subjects
    C Lindholm
    Department of Medical Microbiology and Immunology, Goteborg University, Goteborg, Sweden
    Infect Immun 66:5964-71. 1998
    ..We also showed that the gastric epithelium contributes substantially to the antral cytokine response of the proinflammatory cytokines IL-1beta and IL-6 in addition to IL-8...
  75. pmc Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils
    Olga A Senkovich
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA
    Infect Immun 79:3106-16. 2011
    ..Identification of laminin as the target of AlpA and AlpB will facilitate future investigations of host-pathogen interactions occurring during H. pylori infection...
  76. pmc Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells
    Faïza Maloum
    Département d Anatomie et Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 300:G1065-79. 2011
    ..Our data also indicate that loss of BMP signaling in epithelial gastric cells alone is not sufficient to induce gastric neoplasia...
  77. ncbi Endoscopic submucosal dissection for treatment of gastric subepithelial tumors (with video)
    Andrzej Białek
    Gastroenterology Department, Pomeranian Medical University, Szczecin, Poland
    Gastrointest Endosc 75:276-86. 2012
    ..Endoscopic submucosal dissection (ESD) is a well-accepted method for removing superficial mucosal tumors; however, there is limited data on the use of this method for removing subepithelial tumors...
  78. ncbi Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin
    Timothy L Cover
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Cancer Res 63:951-7. 2003
    ..pylori-infected persons may result from strain-dependent variations in VacA structure...
  79. pmc Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection
    Holly M Scott Algood
    Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA
    J Immunol 183:5837-46. 2009
    ..In contrast to many chronic inflammatory diseases in which IL-17RA signaling promotes an inflammatory response, IL-17RA signaling down-regulates the chronic mononuclear inflammation elicited by H. pylori infection...
  80. ncbi Clinical outcomes of EMR for gastric tumors: historical pilot evaluation between endoscopic submucosal dissection and conventional mucosal resection
    Kenichiro Watanabe
    Department of Internal Medicine, Radiology, Pathology, Saga Prefectural Hospital Koseikan, Saga Japan
    Gastrointest Endosc 63:776-82. 2006
    ..EMR is currently a standard treatment for mucosal gastric tumors. Endoscopic submucosal dissection (ESD) has been developed for en bloc resection...
  81. ncbi Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion
    Thiago M Moraes
    Sao Paulo State University, Department of Physiology, Rubiao Junior, CP 510, CEP 18618 000, Botucatu, Sao Paulo, Brazil
    Chem Biol Interact 180:499-505. 2009
    ..aurantium (OEC) and its majority compound limonene (LIM) to evaluate their effect on gastric mucosa. The OEC (250 mg/kg, p.o.) and LIM (245 mg/kg, p.o...
  82. ncbi Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development
    Xavier Sagaert
    Department of Pathology, University Hospitals of K U Leuven, Minderbroederstraat 12, B 3000 Leuven, Belgium
    Nat Rev Gastroenterol Hepatol 7:336-46. 2010
    ....
  83. ncbi Gastric carcinogenesis and the cancer stem cell hypothesis
    Yoshiro Saikawa
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Gastric Cancer 13:11-24. 2010
    ..NSCs in the normal gastric mucosa are thought to be present in the proliferative zone of the neck/isthmus region, and to undergo a complex ..
  84. pmc Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen
    Wei Guang
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Biol Chem 285:20547-57. 2010
    Helicobacter pylori infection of the gastric mucosa causes an active-chronic inflammation that is strongly linked to the development of duodenal and gastric ulcers and stomach cancer...
  85. pmc Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells
    Emma C Skoog
    Mucosal Immunobiology and Vaccine Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e36378. 2012
    Helicobacter pylori colonizes the mucus niche of the gastric mucosa and is a risk factor for gastritis, ulcers and cancer. The main components of the mucus layer are heavily glycosylated mucins, to which H. pylori can adhere...
  86. ncbi Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers
    Masafumi Nishino
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Clin Pharmacol 51:1079-86. 2011
    ..In this 7-day study, lansoprazole appeared to be more protective than famotidine against low-dose aspirin-induced mucosal injury but a larger well-controlled study is necessary to establish a definitive clinical benefit...
  87. ncbi Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats
    Sang Woon Park
    Digestive Disease Center and DMC MECOX Biomedical Research Center, Jesaeng Hospital, Seongnam, Korea
    J Gastroenterol Hepatol 23:976-84. 2008
    ....
  88. pmc Regulation of IL-18 in Helicobacter pylori infection
    Kazuyoshi Yamauchi
    Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 180:1207-16. 2008
    ..pylori-infected epithelial cells and monocytes. IL-18 levels in H. pylori-infected gastric mucosa were well correlated with the severity of gastric inflammation, confirming that H...
  89. ncbi Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model
    Masaharu Mita
    Laboratory Animal Research Center, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G877-84. 2008
    ..These results suggest that MT in the gastric mucosa might play an important role in the protection against H. pylori-induced gastric ulceration.
  90. pmc Time-series gene expression profiles in AGS cells stimulated with Helicobacter pylori
    Yuan Hai You
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PO Box 5, Changping District, Beijing 102206, China
    World J Gastroenterol 16:1385-96. 2010
    ..To extend the knowledge of the dynamic interaction between Helicobacter pylori (H. pylori) and host mucosa...
  91. pmc BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity
    Nozomi Ishijima
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 286:25256-64. 2011
    ..pylori can exploit BabA-Le(b) binding to trigger TFSS-dependent host cell signaling to induce the transcription of genes that enhance inflammation, development of intestinal metaplasia, and associated precancerous transformations...
  92. ncbi Gastro-duodenal lesions and Helicobacter pylori infection in uremic patients and renal transplant recipients
    H Khedmat
    Baqyiatallah Research Center for Gastroenterology and Liver Diseases, Department of Internal Medicine, Baqyiatallah University of Medical Sciences, Tehran, Iran
    Transplant Proc 39:1003-7. 2007
    ..Upper gastrointestinal (UGI) symptoms are common in uremic patients, and higher serum levels of urea have been suggested to be related to Helicobacter pylori (HP) colonization and UGI mucosal inflammation...
  93. pmc β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia
    Toni A Nagy
    Division of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Gastroenterology 141:553-64. 2011
    Colonization of gastric mucosa by Helicobacter pylori leads to epithelial hyperproliferation, which increases the risk for gastric adenocarcinoma...
  94. ncbi Gastric antisecretory and antiulcer effects of simvastatin in rats
    Mohammad Tariq
    Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia
    J Gastroenterol Hepatol 22:2316-23. 2007
    ..This investigation aimed to study the effect of SIM on experimentally induced gastric acid secretion and ulcer formation...
  95. ncbi Epidemiology and clinical presentation of stress-related peptic damage and chronic peptic ulcer
    Rok Seon Choung
    Dyspepsia Center and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Florida, USA
    Curr Mol Med 8:253-7. 2008
    ..Therefore, our objective is to provide an overview of the epidemiology and clinical presentation of stress-related peptic damage, in order to shed insights into the current understanding of the pathophysiology and treatment...
  96. ncbi Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs
    Neville D Yeomans
    School of Medicine, University of Western Sydney, Penrith South DC, NSW 1797, Australia
    Curr Med Res Opin 25:2785-93. 2009
    ..This was a narrative, descriptive review, rather than a formal systematic review...
  97. ncbi Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression
    Yong Park
    Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, Korea University, Guro Hospital, 80 Guro dong, Guro Gu, Seoul, 152 703, Korea
    Med Oncol 27:1192-9. 2010
    ..008). Immunohistochemical stain showed the specific expression of BMP-2 in cancer cells compared with normal gastric mucosa. In conclusion, serum BMP-2 is associated with progression from early localized gastric cancer to locally ..
  98. pmc Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells
    Jana N Radin
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
    Infect Immun 79:2535-43. 2011
    ....
  99. pmc Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases
    Hiroaki Ogiwara
    Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center 111D, Rm 3A 320, 2002 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Microbiol 47:3493-500. 2009
    ..pylori strains could be an improved predictor of histological inflammation and the potential for atrophy compared with the presence of the vacA s-, m-, and i-region genotypes in Western countries...
  100. ncbi Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer
    Masaaki Kobayashi
    Department of Endoscopy, Niigata University Medical and Dental Hospital, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    J Gastroenterol 46:1064-70. 2011
    ..However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP...
  101. ncbi Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video)
    Quan lin Li
    Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China
    Gastrointest Endosc 75:1153-8. 2012
    ..Endoscopic submucosal dissection (ESD) has been used successfully for the removal of esophageal or gastric SMTs; however, the EGJ has been regarded as a difficult location for ESD because of its narrow lumen and sharp angle...

Research Grants65

  1. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..Our previous results are based on analysis of the whole gastric mucosa. Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric ..
  2. Structure and function of Helicobacter pylori VacA
    Timothy L Cover; Fiscal Year: 2013
    PROJECT SUMMARY (ABSTRACT) Helicobacter pylori is a Gram-negative bacterium that colonizes the gastric mucosa of humans. Although most H...
  3. Effect of Helicobacter pylori cell shape on pathogenesis
    LAURA ELIZABETH MARTINEZ; Fiscal Year: 2013
    ..flagella on its surface, and both flagellar-based motility and chemotaxis are required for infection of the gastric mucosa 13-16. Helical cell shape is thought to enhance H...
  4. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    ..signaling perturbations in gastric parietal cells are reflected in marked acid secretory inhibition in human gastric mucosa. Significance...
  5. DNA recombinational repair in Helicobacter pylori
    Ge Wang; Fiscal Year: 2010
    ..It is highly adapted to maintain persistence in the human gastric mucosa, a niche full of oxidative and acid stress agents that cause bacterial DNA damage. H...
  6. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..atrophy in humans: intestinal metaplasia (characterized by the presence of intestinal goblet cells in the gastric mucosa) and Spasmolytic Polypeptide Expressing Metaplasia (SPEM;characterized by presence of antral type mucous cells ..
  7. Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
    Hartmut Luecke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
  8. Bacterial and Chemical Carcinogens in Gastric Oncogenesis
    D Scott Merrell; Fiscal Year: 2012
    ..H. pylori persists in the gastric mucosa of >50% of humans worldwide for the life of the host, despite intense immune and inflammatory responses, ..
  9. Protein Biomarkers of Gastric Cancer
    Victor E Reyes; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Helicobacter pylori (Hp) infects the gastric mucosa of >50% of the world's population...
  10. Oxidative Injury to Gastric Epithelial Cells by H. pylori
    Sheila E Crowe; Fiscal Year: 2013
    ..In response to infection, phagocytes recruited to the gastric mucosa, become activated and generate reactive oxygen species (ROS) and H...
  11. Immune Evasion by H. pylori
    Victor E Reyes; Fiscal Year: 2010
    ..Hp infects the gastric mucosa of >50% of the world's population...
  12. Anti-inflammatory actions of bone morphogenetic protein signaling in the stomach
    Andrea Todisco; Fiscal Year: 2013
    ..in the regulatory mechanisms that maintain the normal morphological and functional features of the gastric mucosa, leading to the development of diseases such as gastritis, peptic ulcer and gastric cancer...
  13. Molecular Mechanisms of Impaired Angiogenesis in Aging Gastric Mucosa
    Andrzej S Tarnawski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): ABSTRACT Background/Rationale: Gastric mucosa of aging humans and rats (aging gastric mucosa) exhibits increased susceptibility to injury and delayed healing...
  14. Mechanisms of Gastric Mucous Cell Metaplasia
    JAMES RICHARD GOLDENRING; Fiscal Year: 2012
    ..response to the loss of parietal cells and the steps leading to the development of cancer within the atrophic gastric mucosa remain obscure...
  15. Molecular Pathobiology of Gastric Carcinogenesis
    Wael El-Rifai; Fiscal Year: 2013
    ..pylori infection of gastric mucosa persists for several decades before the development of gastric cancer;2) TFF1 protects epithelial cells ..
  16. GNOTOBIOTIC TRANSGENIC MODELS OF THE GASTRIC ECOSYSTEM
    JEFFREY IVAN GORDON; Fiscal Year: 2010
    ..of 5 patients enrolled in a completed study of 2 Swedish communities: 2 patients progressed from a normal gastric mucosa to ChAG during the 4 year interval between their endoscopic examinations;1 progressed from ChAG to Ca;2 ..
  17. Par1-substrates responsible for CagA-mediated pathogenesis of Helicobacter pylori
    Markus Stein; Fiscal Year: 2013
    ..deaths in the world, have been linked to infection with Helicobacter pylori, a bacterium that colonizes the gastric mucosa. H...
  18. Role of adhesin-receptor interaction in H. pylori-induced gastric carcinogenesis
    JENNIFER MCMILLAN NOTO; Fiscal Year: 2012
    ..is a critical step for establishing persistence and permitting survival of this bacterium within the gastric mucosa. Sequence analysis of H...
  19. Purine biosynthesis as a therapeutic target for Helicobacter pylori infection
    Joanna B Goldberg; Fiscal Year: 2013
    ..microaerophilic bacterium and one of the most common human bacterial pathogens, chronically infecting the gastric mucosa of approximately half of the world's population. While infection can be asymptomatic, H...
  20. Mucosal TGF-Beta/IL-6 Axis in the Regulation of T Cell Function
    Lesley E Smythies; Fiscal Year: 2010
    ..regulate T cells appear to vary among different mucosal compartments, since T cells isolated from the normal gastric mucosa proliferate more strongly than T cells from the intestine, and gastric TGF levels are significantly lower than ..
  21. Effects of hyperglycemia on gastric emptying
    Toku Takahashi; Fiscal Year: 2012
    ..Released ghrelin from the gastric mucosa stimulates primarily vagal afferent, accelerating gastric emptying...
  22. Mechanisms of HCI Transport by Gastric Mucosa
    Terry E Machen; Fiscal Year: 2013
    ..While there is a certain level of comprehension, more complete understanding will offer further insight for pathological analysis and new targets for pharmacological intervention. ..
  23. Helicobacter Pylori-Specific Regulatory T Cells that Limit the Host Response
    Thomas G Blanchard; Fiscal Year: 2010
    Helicobacter pylori (H. pylori) colonizes the human gastric mucosa and plays an etiologic role in the development of gastritis, peptic ulcers, and gastric cancer...
  24. Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity
    CLIFFORD RAABE WEISS; Fiscal Year: 2013
    ..Thus, the risk of non-target embolization of these key structures as well as injury or ulceration to the gastric mucosa is a concern...
  25. Pathogenesis of Helicobacter pylori infection
    Timothy L Cover; Fiscal Year: 2013
    ..pylori to colonize and persist in the human gastric mucosa, to understand the molecular mechanisms by which H...
  26. Mechanisms of Gastric Mucosal Transformation in Hip1r-Deficient Mice
    Linda C Samuelson; Fiscal Year: 2012
    ..Hip1r-deficient mice to gastrin-deficient mice, to discern the role of this hormone in the remodeling of the gastric mucosa. Our preliminary studies demonstrate that increased proliferation and hypertrophy are gastrin-dependent...
  27. Helicobacter pylori and the gastric microbial community in rhesus macaques
    Jay V Solnick; Fiscal Year: 2010
    ..includes upregulation of 2- defensin2, elafin, siderocalin, and other innate immune effector molecules in the gastric mucosa. At first glance it seems paradoxical that H...
  28. Genetic and Cellular Basics of H. pylori pathogenesis
    LUCY STUART TOMPKINS; Fiscal Year: 2010
    ..with the host cell surface? And finally, what are the in- vivo consequences of CagA delivery to the gastric mucosa in an animal model? Our previous research directs us to a clear focus on the interaction of the CagA protein ..
  29. Resveratrol Aspirinate Derivatives as Novel Chemopreventive Agents for Colon Canc
    Shengmin Sang; Fiscal Year: 2013
    ..but also can prevent the damage of gastric epithelial cells caused by direct contact between aspirin and gastric mucosa. We plan to test our hypothesis in the following specific aims: 1...
  30. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
    ..The gastric studies will examine the factors controlling histamine release from the gastric mucosa since both the prostaglandins and H2-histamine blockers specifically act by inhibiting histamine-induced acid ..
  31. NON-GASTRIN SECRETAGOGUE PEPTIDE IN ISLET CELL TUMORS
    William Chey; Fiscal Year: 1999
    ..cells in the gastrointestinal tract and/or pancreas and is released postprandially into the circulation or gastric mucosa to stimulate secretion of gastric acid and pepsin; 3 plasma level of NGASP may be found elevated (but not as ..
  32. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Helicobacter pylori colonizes the gastric mucosa of more than half of the world's population...
  33. Exploring Critical Components for MutS Activity in Helicobacter pylori
    Robert J Maier; Fiscal Year: 2011
    ..provided by applicant): Helicobacter pylori is a gastric pathogen of humans, and its persistence in the gastric mucosa has been in part attributed to its ability to counteract the host defense...
  34. GASTRIC H+ ION TRANSPORT--CELLULAR CONTROL MECHANISMS
    CATHERINE CHEW; Fiscal Year: 1999
    ..paracrines and growth factors interact to control hydrochloric acid secretion by parietal cells in the gastric mucosa. Peptic ulcer disease is a widespread clinical problem that results from or is exacerbated by gastric acid ..
  35. H.pylori arginase modulation of ulcers and cancer
    David McGee; Fiscal Year: 2007
    ..Polyamines (produced from ornithine) and arginase are elevated in the gastric mucosa of gastric cancer patients. Preliminary data demonstrate arginase is critical for H...
  36. Acetone metabolism in Helicobacter pylori
    Timothy Hoover; Fiscal Year: 2004
    Helicobacter pylori is a major human pathogen that colonizes the gastric mucosa, leading to gastric inflammation that can progress to chronic gastritis, peptic ulcer, gastric cancer or mucosal-associated lymphoma. The ability of H...
  37. H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVES
    Douglas Berg; Fiscal Year: 2003
    ..Helicobacter pylori (Hp), one of the most genetically diverse of bacterial species, chronically infects the gastric mucosa of more than half of all persons world wide...
  38. CHEMISTRY AND BIOLOGY OF GUT PANCREASTATIN
    JOHN DELVALLE; Fiscal Year: 1992
    ..These actions of pancreastatin, coupled with its localization in the gastric mucosa (Tatemoto; personal communication), prompted us to examine this peptide's effect on gastric parietal cells...
  39. Nickel Metabolism in Helicobacter pylori
    Robert Maier; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Helicobacter pyori is a spiral bacterium that colonizes the gastric mucosa of humans, leading to a variety of gastric diseases that include peptic ulcers, chronic gastritis, mucosal-associated ..
  40. MUCOSAL IMMUNOLOGY OF HELICOBACTER INDUCED GASTRITIS
    Steven Czinn; Fiscal Year: 2007
    ..of IL-12-dependent IFNy-producing TH1 cells that promote protective inflammation when recruited to the gastric mucosa in response to H. pylori challenge...
  41. PHYSIOLOGY AND PATHOPHYSIOLOGY--SECRETIN, CHOLECYSTOKINI
    William Chey; Fiscal Year: 1999
    ..2) The releases and actions of S and CCK are neurally mediated; 3) Secretin- containing endocrine cells in gastric mucosa are controlled by neuropeptides and participate in the regulatory mechanism of gastric acid secretion; 4) The ..
  42. Cannabinoid Acids as Antiinflammatory Agents
    ROBERT ZURIER; Fiscal Year: 2004
    ..These compounds do not alter behavior, are given by mouth, and do not injure gastric mucosa. Oral administration of AjA, a synthetic nonpsychoactive analog of the tetrahydrocannabinol (THC) carboxylic ..
  43. ELECTROPHYSIOLOGY OF GASTRIC ION TRANSPORT
    JEFFREY DEMAREST; Fiscal Year: 1991
    ..The isolated Necturus gastric mucosa and antrum will be used because they exhibit the same ionic transport properties as their mammalian ..
  44. CAMPYLOBACTER PYLORI-INDUCED GASTRIC DISEASE
    Steven Krakowka; Fiscal Year: 1992
    ..In preliminary studies, we have shown the C. pylori will infect gastric mucosa of neonatal gnotobiotic piglets...
  45. REGULATION OF CARBONIC ANHYDRASE II GENE EXPRESSION
    LUCYNDIA MARINO; Fiscal Year: 1993
    ..by previous studies localizing the expression of CA II by in situ hybridization to all of the cells in the gastric mucosa of the newborn but primarily to cells at the glandular base and surface epithelium in mature animals...
  46. REGULATION OF GASTRIC MUCIN SYNTHESIS
    CLEMENT BOLAND; Fiscal Year: 1990
    ..of gastric mucin synthesis and secretion are limited, primarily because of the complexities of intact gastric mucosa. This proposal describes a novel system in which the gastric mucous cell may be studied in isolated cell ..
  47. The mammary gland sodium/iodide symporter (mgNIS)
    Nancy Carrasco; Fiscal Year: 2007
    ..protein that mediates active I- transport in the thyroid and other tissues, including salivary glands, gastric mucosa, and lactating mammary glands (MG). NIS is regulated differently in each tissue...
  48. INTERACTIONS OF HELICOBACTER WITH THE GASTRIC MUCOSA
    Donald Guiney; Fiscal Year: 2001
    DESCRIPTION (taken from the application) Helicobacter pylori is responsible for chronic inflammation in the gastric mucosa. We propose that a long-term carrier state is the result of a balance of pro-inflammatory mediators and regulatory ..
  49. Helicobacter pylori: Pathogenesis and Virulence
    Kenneth Simpson; Fiscal Year: 2005
    ..pylori strain to colonize, invade and damage the gastric mucosa of a given host, and the response that it induces depend strongly on its genotype...
  50. BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILS
    Mimi Takami; Fiscal Year: 2003
    ..pylori infection, has been implicated as a possible mechanism facilitating malignant transformation in the gastric mucosa. Central to the modulation of adhesion and migration of leukocytes in inflammatory processes such as these, is ..
  51. REGULATION AND FUNCTION OF SP-D
    James Fisher; Fiscal Year: 2001
    ..SP-D is expressed in alveolar epithelium and gastric mucosa in cells that are important in maintaining a phospholipid barrier to the environment...
  52. CDX EXPRESSION IN THE GASTROINTESTINAL TRACT
    Debra Silberg; Fiscal Year: 1999
    ..CDX1, though not in the normal stomach, is expressed in intestinal metaplasia of the gastric mucosa, suggesting a role in this pathologic process...
  53. CELLULAR MECHANISMS OF ALCOHOL INJURY OF GASTRIC MUCOSA
    Andrzej Tarnawski; Fiscal Year: 1991
    ..cells, 20 mechanisms of calcium transport and homeostasis in gastric mucosal cells, 3) role of calcium and cytoskeleton in alcohol injury, 4) the cellular mechanisms of adaptation of gastric mucosa to chronic alcohol administration.
  54. FUNCTION & REGULATION OF GASTRIC NA/K/2CL COTRANSPORTERS
    Christian Lytle; Fiscal Year: 2002
    The gastric mucosa secretes digestive hydrochloric acid and pepsin in coordination with dietary intake...
  55. IDENTIFICATION OF HELICOBACTER PYLORI VIRULENCE GENES
    Michael Holland; Fiscal Year: 2004
    DESCRIPTION (Adapted from the Applicant's Abstract): H. pylori chronically infects gastric mucosa and is implicated in the pathogenesis of human gastritis, peptic ulcer disease, and gastric cancer...
  56. EFFECT OF ALCOHOL ON GASTRIC MOTOR FUNCTION
    LINDA KNIGHT; Fiscal Year: 1991
    ..It is believed that ingestion of alcohol contributes to the formation of inflammatory lesions of the gastric mucosa, but the connection between alcohol ingestion and motor disturbances is more controversial...
  57. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2007
    Helicobacter pylori causes an inflammatory infiltrate in gastric mucosa that in about 10% of cases progresses to peptic ulcer disease or gastric cancer...
  58. GASTRIC MUSCOSAL PERMEABILITY AND ION TRANSPORT
    David Fromm; Fiscal Year: 1980
    ..Recent studies suggest that the carboxyl group of salicylate is key to its damaging effects on the gastric mucosa. The relationships between the metabolic and permeability effects induced by salicylate, however, are not ..
  59. GASTRIC MUCOSAL INJURY
    PETER KVIETYS; Fiscal Year: 1993
    ..of this proposal is to fully characterize the role of neutrophils in the ethanol-induced injury to the gastric mucosa. To this end, an in vivo model of ethanol-induced gastritis has been developed which involves perfusing the ..
  60. BIOCHEMICAL ROLE OF CYCLIC AMP IN THE GASTRIC MUCOSA
    ERWIN REIMANN; Fiscal Year: 1980
    ..It has been known for some time that gastrin, histamine, and acetylcholine regulate the secretion of acid in the gastric mucosa, but the precise nature of the interaction of these stimuli as well as their action on the parietal cell is ..
  61. Clinical Studies with Phospholipid-Associated NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2004
    ..i.d.) with diclofenac-PC, except in this case we will add a third arm of the study in which the subjects are administered the COX- inhibitor, Celecoxib, at a dose (200 mg b.i.d.) having equivalent therapeutic efficacy to diclofenac. ..
  62. PHOSPHOLIPIDS AND ULCER PROTECTION
    Lenard Lichtenberger; Fiscal Year: 2002
    ....
  63. GASTRIC H+ ION TRANSPORT - CELLULAR CONTROL MECHANISMS
    CATHERINE CHEW; Fiscal Year: 2008
    ..paracrines and growth factors interact to control hydrochloric acid secretion by parietal cells in the gastric mucosa. Gastroesophageal reflux and peptic ulcer disease are widespread clinical problems that result from or are ..
  64. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2007
    ..Intestinal metaplasia is a condition that predisposes the gastric mucosa to cancer. Central to initiating these important alterations are changes in the parietal cell population...
  65. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..