Genomes and Genes
Summary: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Publications271 found, 100 shown here
- Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cellsN Murata-Kamiya
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Oncogene 26:4617-26. 2007..Intestinal metaplasia is a precancerous lesion of the stomach characterized by transdifferentiation of the gastric mucosa to an intestinal phenotype. The H...
- Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant ratsKazuko Shichijo
Department of Molecular Pathology and Radiation Biophysics, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Pathology, Nagasaki Medical Center, Japan
Dig Dis Sci 48:340-8. 2003..Our results indicate that overexpression of heat shock protein 70 in the stomach seems to protect against gastric ulcers through its cytoprotective effects on gastric mucosa by increasing mucosal blood flow.
- Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancerShiro Oka
Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Gastrointest Endosc 64:877-83. 2006..In EMR of early gastric cancer (EGC), en bloc resection reduces the risk of residual cancer. Endoscopic submucosal dissection (ESD) now allows en bloc resection of large EGCs...
- Gastric mucosal defense and cytoprotection: bench to bedsideLoren Laine
Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Gastroenterology 135:41-60. 2008The gastric mucosa maintains structural integrity and function despite continuous exposure to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue...
- CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer riskMitsuru Kaise
Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
Helicobacter 13:35-41. 2008..We investigated this linkage in noncancerous gastric mucosa infected with H. pylori.
- Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)John L Wallace
Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Br J Pharmacol 159:1236-46. 2010..We evaluated the gastrointestinal safety and anti-inflammatory efficacy of a novel hydrogen sulphide-releasing derivative of naproxen, ATB-346 [2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester]...
- Protective effects of DIDS against ethanol-induced gastric mucosal injury in ratsWei Zhao
Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Acta Biochim Biophys Sin (Shanghai) 41:301-8. 2009..Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway...
- Host-bacterial interactions in Helicobacter pylori infectionManuel R Amieva
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Gastroenterology 134:306-23. 2008..pylori are spiral-shaped gram-negative bacteria with polar flagella that live near the surface of the human gastric mucosa. They have evolved intricate mechanisms to avoid the bactericidal acid in the gastric lumen and to survive ..
- Redox biology and gastric carcinogenesis: the role of Helicobacter pyloriOsamu Handa
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Redox Rep 16:1-7. 2011..Understanding the molecular mechanism of H. pylori-induced carcinogenesis is important for developing new strategies against gastric cancer...
- Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley ratsS Q Wasman
Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Teknologi Malaysia, 81310, UTM Skudai, Johor, Malaysia
Indian J Exp Biol 49:767-72. 2011..65. Results of this study showed that pretreatment with ethonolic extract of A. paniculata ethanolic provided significant protection against gastric ulcer by regulating of pH, mucous production and antioxidant property...
- Comparison between magnifying endoscopy and histological, culture and urease test findings from the gastric mucosa of the corpusK Yagi
Department of Internal Medicine, Niigata Prefectural Yoshida Hospital, Japan
Endoscopy 34:376-81. 2002..In a previous study, the endoscopic features and a magnified view of the gastric mucosa of the corpus of H. pylori-negative normal stomach were described...
- Topographic differences in gastric micromucosal patterns observed by magnifying endoscopy with narrow band imagingMasashi Kawamura
Department of Gastroenterology, JR Sendai Hospital, Miyagi, Japan
J Gastroenterol Hepatol 26:477-83. 2011..The aim of this study was to investigate the differences in distributions of gastric micromucosal structures observed by magnifying narrow band imaging (NBI) endoscopy among patients with different H. pylori-associated diseases...
- Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in miceJohn Y Kao
Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
Gastroenterology 138:1046-54. 2010..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
- Gastric helicobacters in domestic animals and nonhuman primates and their significance for human healthFreddy Haesebrouck
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Clin Microbiol Rev 22:202-23, Table of Contents. 2009Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans...
- Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagAManuel R Amieva
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 300:1430-4. 2003..CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions...
- Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosaF Luzza
Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Catanzaro, Italy
J Immunol 165:5332-7. 2000..inhibition of IL-8 secretion, indicating that IL-17 contributes to enhance IL-8 in the HP-colonized gastric mucosa. Consistently, stimulation of MKN 28 cells, a gastric epithelial cell line, with IL-17 increased IL-8 ..
- SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA proteinHideaki Higashi
Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Science 295:683-6. 2002..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2...
- Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient miceL E Smythies
Department of Medicine, Pathology, and Comparative Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 165:1022-9. 2000..pylori infection and demonstrate that up-regulated production of IFN-gamma, in the absence of the opposing effects of IL-4 (and possibly IL-10), plays a pivotal role in promoting H. pylori-induced mucosal inflammation...
- Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?John L Wallace
Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
Physiol Rev 88:1547-65. 2008....
- SPARC is associated with gastric cancer progression and poor survival of patientsZhong sheng Zhao
Departments of Pathology and Surgery, Zhejiang Provincal People s Hospital, Hangzhou, Zhejiang, People s Republic of China
Clin Cancer Res 16:260-8. 2010..The present study investigated the clinical significance of secreted protein, acidic and rich in cysteine (SPARC), in the development and progression of gastric cancer...
- Correlation between narrow band imaging and nonneoplastic gastric pathology: a pilot feasibility trialAjay Bansal
Department of Gastroenterology and Pathology, University of Kansas School of Medicine, Kansas City, Missouri, USA
Gastrointest Endosc 67:210-6. 2008..A novel narrow band imaging (NBI) system is able to visualize the mucosal and vascular network in the GI tract...
- Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritisTomomitsu Tahara
Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
Gastrointest Endosc 70:246-53. 2009..Magnifying narrow-band imaging (NBI) endoscopy clearly visualizes superficial gastric mucosal patterns and capillary patterns...
- Helicobacter pylori and gastrointestinal tract adenocarcinomasRichard M Peek
Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
Nat Rev Cancer 2:28-37. 2002....
- Clinical outcomes of EMR for gastric tumors: historical pilot evaluation between endoscopic submucosal dissection and conventional mucosal resectionKenichiro Watanabe
Department of Internal Medicine, Radiology, Pathology, Saga Prefectural Hospital Koseikan, Saga Japan
Gastrointest Endosc 63:776-82. 2006..EMR is currently a standard treatment for mucosal gastric tumors. Endoscopic submucosal dissection (ESD) has been developed for en bloc resection...
- Gastric MALT lymphoma: a model of chronic inflammation-induced tumor developmentXavier Sagaert
Department of Pathology, University Hospitals of K U Leuven, Minderbroederstraat 12, B 3000 Leuven, Belgium
Nat Rev Gastroenterol Hepatol 7:336-46. 2010....
- Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretionThiago M Moraes
Sao Paulo State University, Department of Physiology, Rubiao Junior, CP 510, CEP 18618 000, Botucatu, Sao Paulo, Brazil
Chem Biol Interact 180:499-505. 2009..aurantium (OEC) and its majority compound limonene (LIM) to evaluate their effect on gastric mucosa. The OEC (250 mg/kg, p.o.) and LIM (245 mg/kg, p.o...
- Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogenWei Guang
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Biol Chem 285:20547-57. 2010Helicobacter pylori infection of the gastric mucosa causes an active-chronic inflammation that is strongly linked to the development of duodenal and gastric ulcers and stomach cancer...
- Gastric carcinogenesis and the cancer stem cell hypothesisYoshiro Saikawa
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
Gastric Cancer 13:11-24. 2010..NSCs in the normal gastric mucosa are thought to be present in the proliferative zone of the neck/isthmus region, and to undergo a complex ..
- Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cellsEmma C Skoog
Mucosal Immunobiology and Vaccine Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
PLoS ONE 7:e36378. 2012Helicobacter pylori colonizes the mucus niche of the gastric mucosa and is a risk factor for gastritis, ulcers and cancer. The main components of the mucus layer are heavily glycosylated mucins, to which H. pylori can adhere...
- Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosaNicole Wittschier
University of Munster, Institute for Pharmaceutical Biology and Phytochemistry, Hittorfstrasse 56, D 48149 Munster, Germany
J Ethnopharmacol 125:218-23. 2009..Additionally the influence of Glycyrrhiza glabra secondary compounds on the bacterial adhesion of Porphyromonas gingivalis, a major pathogen for induction of periodontal inflammations was to be investigated...
- Gastro-duodenal lesions and Helicobacter pylori infection in uremic patients and renal transplant recipientsH Khedmat
Baqyiatallah Research Center for Gastroenterology and Liver Diseases, Department of Internal Medicine, Baqyiatallah University of Medical Sciences, Tehran, Iran
Transplant Proc 39:1003-7. 2007..Upper gastrointestinal (UGI) symptoms are common in uremic patients, and higher serum levels of urea have been suggested to be related to Helicobacter pylori (HP) colonization and UGI mucosal inflammation...
- Regulation of IL-18 in Helicobacter pylori infectionKazuyoshi Yamauchi
Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 180:1207-16. 2008..pylori-infected epithelial cells and monocytes. IL-18 levels in H. pylori-infected gastric mucosa were well correlated with the severity of gastric inflammation, confirming that H...
- Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse modelMasaharu Mita
Laboratory Animal Research Center, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
Am J Physiol Gastrointest Liver Physiol 294:G877-84. 2008..These results suggest that MT in the gastric mucosa might play an important role in the protection against H. pylori-induced gastric ulceration.
- Time-series gene expression profiles in AGS cells stimulated with Helicobacter pyloriYuan Hai You
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PO Box 5, Changping District, Beijing 102206, China
World J Gastroenterol 16:1385-96. 2010..To extend the knowledge of the dynamic interaction between Helicobacter pylori (H. pylori) and host mucosa...
- Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of ratsSang Woon Park
Digestive Disease Center and DMC MECOX Biomedical Research Center, Jesaeng Hospital, Seongnam, Korea
J Gastroenterol Hepatol 23:976-84. 2008....
- BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activityNozomi Ishijima
Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 286:25256-64. 2011..pylori can exploit BabA-Le(b) binding to trigger TFSS-dependent host cell signaling to induce the transcription of genes that enhance inflammation, development of intestinal metaplasia, and associated precancerous transformations...
- Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteersMasafumi Nishino
First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
J Clin Pharmacol 51:1079-86. 2011..In this 7-day study, lansoprazole appeared to be more protective than famotidine against low-dose aspirin-induced mucosal injury but a larger well-controlled study is necessary to establish a definitive clinical benefit...
- IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosisShui Ping Tu
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
Cancer Res 71:4247-59. 2011..It is upregulated in the gastric mucosa by chronic Helicobacter infection; however, whether it plays a positive or negative role in inflammation-..
- Epidemiology and clinical presentation of stress-related peptic damage and chronic peptic ulcerRok Seon Choung
Dyspepsia Center and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Florida, USA
Curr Mol Med 8:253-7. 2008..Therefore, our objective is to provide an overview of the epidemiology and clinical presentation of stress-related peptic damage, in order to shed insights into the current understanding of the pathophysiology and treatment...
- Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progressionYong Park
Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, Korea University, Guro Hospital, 80 Guro dong, Guro Gu, Seoul, 152 703, Korea
Med Oncol 27:1192-9. 2010..008). Immunohistochemical stain showed the specific expression of BMP-2 in cancer cells compared with normal gastric mucosa. In conclusion, serum BMP-2 is associated with progression from early localized gastric cancer to locally ..
- Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugsNeville D Yeomans
School of Medicine, University of Western Sydney, Penrith South DC, NSW 1797, Australia
Curr Med Res Opin 25:2785-93. 2009..This was a narrative, descriptive review, rather than a formal systematic review...
- Gastric antisecretory and antiulcer effects of simvastatin in ratsMohammad Tariq
Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia
J Gastroenterol Hepatol 22:2316-23. 2007..This investigation aimed to study the effect of SIM on experimentally induced gastric acid secretion and ulcer formation...
- β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epitheliaToni A Nagy
Division of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
Gastroenterology 141:553-64. 2011Colonization of gastric mucosa by Helicobacter pylori leads to epithelial hyperproliferation, which increases the risk for gastric adenocarcinoma...
- Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cellsJana N Radin
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
Infect Immun 79:2535-43. 2011....
- Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseasesHiroaki Ogiwara
Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center 111D, Rm 3A 320, 2002 Holcombe Blvd, Houston, TX 77030, USA
J Clin Microbiol 47:3493-500. 2009..pylori strains could be an improved predictor of histological inflammation and the potential for atrophy compared with the presence of the vacA s-, m-, and i-region genotypes in Western countries...
- Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancerMasaaki Kobayashi
Department of Endoscopy, Niigata University Medical and Dental Hospital, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
J Gastroenterol 46:1064-70. 2011..However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP...
- Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video)Quan lin Li
Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China
Gastrointest Endosc 75:1153-8. 2012..Endoscopic submucosal dissection (ESD) has been used successfully for the removal of esophageal or gastric SMTs; however, the EGJ has been regarded as a difficult location for ESD because of its narrow lumen and sharp angle...
- Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewalPallab Maity
Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
J Biol Chem 283:14391-401. 2008..that lansoprazole activates vascular epidermal growth factor-mediated controlled angiogenesis to repair gastric mucosa. Lansoprazole also stimulates the healing of already formed ulcers induced by indomethacin...
- Role of innate immunity in Helicobacter pylori-induced gastric malignancyRichard M Peek
Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232 2279, USA
Physiol Rev 90:831-58. 2010..pylori-infected individuals who can then be targeted for therapeutic intervention...
- What a disorder: proinflammatory signaling pathways induced by Helicobacter pyloriSteffen Backert
University College Dublin, School of Biomolecular and Biomedical Sciences, Belfield Campus, Dublin 4, Ireland
Trends Microbiol 18:479-86. 2010..Here we discuss the pros and cons of the multiple signaling activities in the induction of proinflammatory responses and associated problems, and give suggestions for finding ways out of this dilemma...
- Gene expression profiling in human gastric mucosa infected with Helicobacter pyloriVéronique J Hofman
Faculty of Medicine, Inserm ERI 21, Nice Cedex, France
Mod Pathol 20:974-89. 2007..were selected for the presence of chronic active gastritis, in absence of metaplasia and dysplasia of the gastric mucosa. Infected antral and fundic biopsies exhibited distinct transcriptional responses...
- The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatmentM Stolte
Department of Pathology, Klinikum Bayreuth, Preuschwitzerstrasse 101, 95445 Bayreuth, Germany
Can J Gastroenterol 15:591-8. 2001....
- Smoking and the pathogenesis of gastroduodenal ulcer--recent mechanistic updatePallab Maity
Department of Physiology, Indian Institute of Chemical Biology, Kolkata, India
Mol Cell Biochem 253:329-38. 2003..Nicotine also decreases prostaglandin generation in the gastric mucosa of smokers, thereby making the mucosa susceptible to ulceration...
- Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcomeSaori Fujimoto
Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 5:49-58. 2007..The blood grou...
- Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the NetherlandsAnnemarie C de Vries
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Gastroenterology 134:945-52. 2008..Quantification of gastric cancer risk in patients with premalignant gastric lesions is unclear, however. Consequently, endoscopic surveillance is controversial, especially in Western populations...
- MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoySara K Linden
Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
PLoS Pathog 5:e1000617. 2009..pylori infected mice. Thus, MUC1 protects the epithelium from non-MUC1 binding bacteria by inhibiting adhesion to the cell surface by steric hindrance, and from MUC1-binding bacteria by acting as a releasable decoy...
- Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responsesK Robinson
Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
Gut 57:1375-85. 2008..To address the hypothesis that the human acquired immune response to H. pylori influences pathogenesis, we characterised the gastric T helper (Th) and regulatory T cell (Treg) response of infected patients...
- Comparison of five PCR methods for detection of Helicobacter pylori DNA in gastric tissuesJ J Lu
Division of Clinical Pathology, Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan
J Clin Microbiol 37:772-4. 1999..The results of this study indicate that of the five PCR methods examined, the ureC (glmM) gene PCR is the most sensitive and specific for the detection of H. pylori in gastric biopsy specimens...
- Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapyCorrado Blandizzi
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy
Pharmacol Res 59:90-100. 2009....
- Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonizationTomokazu Mizuno
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
World J Gastroenterol 11:6305-11. 2005..To determine the role of interleukin (IL)-17 in gastric ulcerogenesis...
- MicroRNA signatures in Helicobacter pylori-infected gastric mucosaKayoko Matsushima
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
Int J Cancer 128:361-70. 2011..microRNA (miRNA), a non-coding RNA that controls gene expression mainly through translational repression, in gastric mucosa infected with Helicobacter pylori. Using endoscopic biopsy specimens, miRNA expression patterns in H...
- Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: role of endogenous sulphydryls and nitric oxideHélio Kushima
Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista UNESP, Botucatu, CP 510, CEP 18608 000, Botucatu, Sao Paulo, Brazil
J Ethnopharmacol 101:61-7. 2005..By comparative effect (intraduodenal and oral route), we observed that HAE was better for local activity in gastric mucosa than in systemic action...
- Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissuesT Kobayashi
Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University, Nagoya, Aichi, 454-8509, Japan
Pharmacol Res 43:23-30. 2001..teprenone administration caused a decrease in MPO activity and an increase in adherent mucus content in the gastric mucosa of the intact region...
- IL-17 is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse modelSatoshi Shiomi
Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Helicobacter 13:518-24. 2008..In this study, the contributions of IL-17 to the induction of gastric inflammation and to the protection from H. pylori infection were investigated using IL-17 gene-knockout (IL-17(-/-)) mice...
- Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin CT Pohle
Department of Medicine B, University of Munster, Munster, Germany
Aliment Pharmacol Ther 15:677-87. 2001..The roles of active oxygen metabolites and anti-oxidative defenses in aspirin (ASA)-induced gastric damage have been little studied...
- A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infectionM A Poles
Department of Medicine, UCLA School of Medicine, UCLA Center for HIV and Digestive Diseases, Los Angeles, California 90095, USA
J Virol 75:8390-9. 2001..We conclude that, based on these findings, the gastrointestinal mucosa represents a favored target for HIV-1, in part due to its large population of CXCR4(+) CCR5(+) target cells and not to differences in the virus that it contains...
- Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivoG Graziani
Dipartimento di Scienza degli Alimenti, Universita di Napoli, Italy
Gut 54:193-200. 2005..Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa...
- Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countriesY Yamaoka
Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Microbiol 37:2274-9. 1999..iceA status shows considerable geographic differences, and neither iceA nor combinations of iceA, vacA, and cagA were helpful in predicting the clinical presentation of an H. pylori infection...
- Runx3 expression in gastrointestinal tract epithelium: resolving the controversyK Ito
Institute of Molecular and Cell Biology, Proteos, Singapore
Oncogene 28:1379-84. 2009..G-poly primarily recognizes the region beyond 234 and hence, is unable to detect Runx3 in this tissue...
- Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talkV Sibilia
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milan, Italy
Br J Pharmacol 154:688-97. 2008Ghrelin, a gut-brain peptide, is considered a gastroprotective factor in gastric mucosa. We investigated the role of prostaglandins (PG) and the possible interplay between PGs and nitric oxide (NO) in ghrelin gastroprotection against ..
- Luminal amino acid sensing in the rat gastric mucosaHisayuki Uneyama
Physiology and Nutrition Group, Institute of Life Sciences, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
Am J Physiol Gastrointest Liver Physiol 291:G1163-70. 2006..Altogether, these results strongly suggest the existence of a sensing system for glutamate in the rat gastric mucosa. Thus luminal glutamate would enhance the electrophysiological firing rate of afferent fibers from the vagus ..
- Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?Ebru Turkkan
Department of Internal Medicine, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
J Gastroenterol 44:66-70. 2009..In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia...
- Exfoliation of gastric pit-parietal cells into the gastric lumen associated with a stimulation of isolated rat gastric mucosa in vitro: a morphological study by the application of cryotechniquesFumiyo Aoyama
Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan
Histochem Cell Biol 129:785-93. 2008..In a rat gastric mucosa isolated after stimulation, a number of cells were exfoliated into the gastric lumen of the pit region...
- Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protectionIsao Wada
Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
Biochem Biophys Res Commun 349:611-8. 2006The real mechanism of adaptive cytoprotection in the gastric mucosa is not well established...
- Successful antibiotic treatment of Helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphomasM Raderer
Department of Medicine I, Division of Oncology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Gut 55:616-8. 2006The role of antibiotic treatment in early stage gastric mucosa associated lymphoid tissue (MALT) lymphoma not associated with Helicobacter pylori infection has not been investigated.
- Roles of alpha and beta carbonic anhydrases of Helicobacter pylori in the urease-dependent response to acidity and in colonization of the murine gastric mucosaStéphanie Bury-Moné
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Infect Immun 76:497-509. 2008..mice were infected by SS1 Delta(beta-CA-HP) or by a SS1 double CA mutant, the inflammation scores of the mouse gastric mucosa were strongly reduced. In conclusion, CA contribute to the urease-dependent response to acidity of H...
- Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide ProductionRupesh Chaturvedi
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Gastroenterology 139:1686-98, 1698.e1-6. 2010..We determined if spermine inhibits iNOS-mediated immunity by reducing L-Arg uptake into macrophages...
- Ghrelin and Helicobacter pylori infectionHiroyuki Osawa
Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
World J Gastroenterol 14:6327-33. 2008..mass index, plasma ghrelin concentration, gastric ghrelin mRNA, and the number of ghrelin producing cells in gastric mucosa are significantly lower in H pylori infected subjects than in H pylori-negative controls...
- Gastroprotection by vitamin C--a heme oxygenase-1-dependent mechanism?Jan C Becker
Department of Medicine B, University of Munster, Munster, Germany
Biochem Biophys Res Commun 312:507-12. 2003....
- Cellular and molecular mechanisms of gastrointestinal ulcer healingAndrzej S Tarnawski
Department of Medicine, VA Long Beach Healthcare System Long Beach, Long Beach, California 90822, USA
Dig Dis Sci 50:S24-33. 2005..Future directions to accelerate and improve healing include the use of stem cells and tissue engineering...
- Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pyloriHiroyuki Osawa
Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi, Japan 329 0498
J Clin Endocrinol Metab 90:10-6. 2005..pylori-negative subjects. The expression levels of ghrelin mRNA and ghrelin-producing cells in the gastric mucosa were quantified with real-time quantitative RT-PCR and immunohistochemistry, respectively...
- Expression of a 31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary and metastatic gastric carcinomasR Lotan
Department of Tumor Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Int J Cancer 56:474-80. 1994....
- Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosineMasaru Odashima
First Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
Dig Dis Sci 47:2799-804. 2002..inducible HSP70), which is known as an endogenous cytoprotectant in a wide variety of cells, including rat gastric mucosa in vitro and in vivo...
- Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infectionIl Ran Hwang
Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 123:1793-803. 2002....
- Higher gastric cycloxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patientsBor Shyang Sheu
Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan
Clin Cancer Res 9:5245-51. 2003..pylori eradication could reduce COX-2 expression...
- Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretionS P Cole
Department of Medicine, University of California, San Diego, La Jolla 92093, USA
Infect Immun 65:843-6. 1997..Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells...
- EMR for early gastric cancer in Korea: a multicenter retrospective studyJae J Kim
Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
Gastrointest Endosc 66:693-700. 2007..EMR has been accepted as a treatment modality for selected cases of early gastric cancer (EGC) in Japan. However, long-term outcomes after EMR for EGC have not been fully documented...
- Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cellsSong Ze Ding
Division of Gastroenterology and Hepatology, Department of Medicine, P O Box 800708, Charlottesville, VA 22908 0708, USA
Infect Immun 75:4030-9. 2007..pylori. These results indicate that bacterial factors and the host inflammatory response confer oxidative stress to the gastric epithelium during H. pylori infection that may lead to apoptosis...
- Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in JapanMitsushige Sugimoto
First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, 431 3192, Japan
Cancer Epidemiol Biomarkers Prev 15:1929-34. 2006..The aim of this study was to clarify the association of the chymase gene (CMA/B) and ACE polymorphisms with susceptibility to gastric cancer and peptic ulcer...
- Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil proteinO Lefebvre
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, Communaute Urbaine de Strasbourg, France
Science 274:259-62. 1996To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated...
- The spatial orientation of Helicobacter pylori in the gastric mucusSören Schreiber
Institut fur Physiologie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
Proc Natl Acad Sci U S A 101:5024-9. 2004..H. pylori thus uses the gastric mucus pH gradient for chemotactic orientation...
- Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
Cancer Sci 96:835-43. 2005..pylori strains carrying biologically more active CagA are more virulent than those with less active CagA and are more closely associated with gastric carcinoma...
- Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cellsJi Hye Seo
Department of Pharmacology and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
Ann N Y Acad Sci 1096:29-36. 2007..PAR-2 agonist peptide augmented H. pylori-induced COX-2 expression in AGS cells. H. pylori induces COX-2 expression, which is mediated by both activation and expression of PAR-2 in gastric epithelial cells...
- Eosinophil interactions with Haemonchus contortus larvae in the ovine gastrointestinal tractA Balic
Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Victoria 3010, Australia
Parasite Immunol 28:107-15. 2006..In addition, they also suggest that effective killing by tissue eosinophils may depend on other microenvironmental factors such as intra-epithelial mast cells and IL-4...
- DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cellsSuck Chei Choi
Digestive Disease Research Institute, Wonkwang University School of Medicine, Chonbuk, Korea
World J Gastroenterol 12:4850-8. 2006..To investigate whether, or how, DA-9601, which is a new gastroprotective agent, inhibits TNF-alpha-induced inflammatory signals in gastric epithelial AGS cells...
- Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasiaWataru Shibata
Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Gastroenterology 138:1022-34.e1-10. 2010..We derived mice with a conditional knockout of IKKbeta in gastric epithelial cells (GECs) and myeloid cells, and examined responses to ionizing radiation (IR) and Helicobacter felis infection...
- The effect of Helicobacter felis and Helicobacter bizzozeronii on the gastric mucosa in Mongolian gerbils: a sequential pathological studyM de Bock
Departments of Pathology, Bacteriology and Avian Diseases, Faculty of Medicine, Ghent University, Belgium
J Comp Pathol 135:226-36. 2006..The mechanism by which H. felis induces PC necrosis and apoptosis remains unclear. The observed flagellar contact and NF-kappaB activation may play an important role in H. felis-associated inflammation...
- Gastroduodenal mucosal defenseAmy Zhu
West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 10:548-54. 2008..This article also summarizes some new findings on the genetics of ulcer formation and the effects of age and gender on mucosal defense and touches on current developments in drugs, including considerations for future therapeutic agents...
- Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in ratsChun Ying Li
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, South Korea
Alcohol 42:683-7. 2008..These results suggest that the gastroprotective effect of C3G removes the ethanol-induced lipid peroxides and free radicals and that it may offer a potential remedy for the treatment of gastric lesions...
- Target molecules of molecular chaperone (HSP70 family) in injured gastric mucosa in vivoMichiro Otaka
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
Life Sci 84:664-7. 2009..In the present study, gastric mucosal proteins that specifically bind to the HSP70 family (HSC70) were analyzed using HSC70-affinity chromatography...
- Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cellsMichiko Tanaka-Shintani
Kobe University School of Medicine, Faculty of Health Sciences, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
J Gastroenterol 40:345-9. 2005..We examined the distribution of ghrelin-immunoreactive cells in human gastric mucosa.
- UREASE AND GENE EXPRESSION OF HELICOBACTER PYLORIHARRY MOBLEY; Fiscal Year: 2007..This species, whose niche is highly restricted to the gastric mucosa of humans, has adopted a strategy of survival that includes synthesis of urease as its most abundant cellular ..
- REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIYoshio Yamaoka; Fiscal Year: 2010..Our previous results are based on analysis of the whole gastric mucosa. Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric ..
- GASTRIC H+ ION TRANSPORT-CELLULAR CONTROL MECHANSIMSCATHERINE CHEW; Fiscal Year: 2005..paracrines and growth factors interact to control hydrochloric acid secretion by parietal cells in the gastric mucosa. Gastroesophageal reflux and peptic ulcer disease are widespread clinical problems that result from or are ..
- Structure-Function Studies of the Proton-Gated Urea Channel from H. PyloriHartmut Luecke; Fiscal Year: 2010Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
- Structure-Function Studies of the Proton-Gated Urea Channel from H. PyloriHartmut Luecke; Fiscal Year: 2009Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
- Structure-Function Studies of the Proton-Gated Urea Channel from H. PyloriHartmut Luecke; Fiscal Year: 2009Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
- Acetone metabolism in Helicobacter pyloriTimothy Hoover; Fiscal Year: 2004Helicobacter pylori is a major human pathogen that colonizes the gastric mucosa, leading to gastric inflammation that can progress to chronic gastritis, peptic ulcer, gastric cancer or mucosal-associated lymphoma. The ability of H...
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL TRENT; Fiscal Year: 2006..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
- Helicobacter pylori: Tactic Responses and Persistence in the Gastric MucosaPAUL STOKES HOFFMAN; Fiscal Year: 2010....
- Oxidative Injury to Gastric Epithelial Cells by H. pyloriSheila E Crowe; Fiscal Year: 2010..Phagocytic leukocytes recruited to the gastric mucosa during infection become activated, generating reactive oxygen species (ROS) that alter gastric epithelial cell ..
- Oxidative Injury to Gastric Epithelial Cells by H. pyloriSheila Crowe; Fiscal Year: 2009..Phagocytic leukocytes recruited to the gastric mucosa during infection become activated, generating reactive oxygen species (ROS) that alter gastric epithelial cell ..
- Helicobacter pylori: Tactic Responses and Persistence in the Gastric MucosaPaul Hoffman; Fiscal Year: 2009....
- Helicobacter pylori: Tactic Responses and Persistence in the Gastric MucosaPaul Hoffman; Fiscal Year: 2007..Understanding the fundamental mechanisms associated with acid survival and gastric colonization underpins all eradicative strategies from vaccines to novel therapeutics against a pathogen that infects half of the world's population. ..
- H.pylori arginase modulation of ulcers and cancerDavid McGee; Fiscal Year: 2007..Polyamines (produced from ornithine) and arginase are elevated in the gastric mucosa of gastric cancer patients. Preliminary data demonstrate arginase is critical for H...
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL TRENT; Fiscal Year: 2007..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL STEPHEN TRENT; Fiscal Year: 2010..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
- MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESMICHAEL TRENT; Fiscal Year: 2009
- Bacterial and Chemical Carcinogens in Gastric OncogenesisAndre Dubois; Fiscal Year: 2009..H. pylori persists in the gastric mucosa of >50% of humans worldwide for the life of the host, despite intense immune and inflammatory responses, ..
- H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVESDouglas Berg; Fiscal Year: 2003..Helicobacter pylori (Hp), one of the most genetically diverse of bacterial species, chronically infects the gastric mucosa of more than half of all persons world wide...
- UREASE AND GENE EXPRESSION OF HELICOBACTER PYLORIHARRY MOBLEY; Fiscal Year: 2003..This species, whose niche is highly restricted to the gastric mucosa of humans, has adopted a strategy of survival that includes synthesis of urease as its most abundant cellular ..
- Nickel Metabolism in Helicobacter pyloriRobert Maier; Fiscal Year: 2006Helicobacter pyori is a spiral bacterium that colonizes the gastric mucosa of humans, leading to a variety of gastric diseases that include peptic ulcers, chronic gastritis, mucosal-associated lymphomas, and adenocarcinomas of the lower ..