gastric mucosa

Summary

Summary: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.

Top Publications

  1. ncbi Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
    N Murata-Kamiya
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 26:4617-26. 2007
  2. ncbi Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats
    Kazuko Shichijo
    Department of Molecular Pathology and Radiation Biophysics, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Pathology, Nagasaki Medical Center, Japan
    Dig Dis Sci 48:340-8. 2003
  3. ncbi Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer
    Shiro Oka
    Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 64:877-83. 2006
  4. doi Gastric mucosal defense and cytoprotection: bench to bedside
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 135:41-60. 2008
  5. doi CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk
    Mitsuru Kaise
    Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Helicobacter 13:35-41. 2008
  6. pmc Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)
    John L Wallace
    Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Br J Pharmacol 159:1236-46. 2010
  7. ncbi Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats
    Wei Zhao
    Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Acta Biochim Biophys Sin (Shanghai) 41:301-8. 2009
  8. doi Host-bacterial interactions in Helicobacter pylori infection
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 134:306-23. 2008
  9. doi Redox biology and gastric carcinogenesis: the role of Helicobacter pylori
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 16:1-7. 2011
  10. ncbi Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats
    S Q Wasman
    Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Teknologi Malaysia, 81310, UTM Skudai, Johor, Malaysia
    Indian J Exp Biol 49:767-72. 2011

Detail Information

Publications271 found, 100 shown here

  1. ncbi Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
    N Murata-Kamiya
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 26:4617-26. 2007
    ..Intestinal metaplasia is a precancerous lesion of the stomach characterized by transdifferentiation of the gastric mucosa to an intestinal phenotype. The H...
  2. ncbi Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats
    Kazuko Shichijo
    Department of Molecular Pathology and Radiation Biophysics, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Pathology, Nagasaki Medical Center, Japan
    Dig Dis Sci 48:340-8. 2003
    ..Our results indicate that overexpression of heat shock protein 70 in the stomach seems to protect against gastric ulcers through its cytoprotective effects on gastric mucosa by increasing mucosal blood flow.
  3. ncbi Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer
    Shiro Oka
    Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 64:877-83. 2006
    ..In EMR of early gastric cancer (EGC), en bloc resection reduces the risk of residual cancer. Endoscopic submucosal dissection (ESD) now allows en bloc resection of large EGCs...
  4. doi Gastric mucosal defense and cytoprotection: bench to bedside
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 135:41-60. 2008
    The gastric mucosa maintains structural integrity and function despite continuous exposure to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue...
  5. doi CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk
    Mitsuru Kaise
    Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Helicobacter 13:35-41. 2008
    ..We investigated this linkage in noncancerous gastric mucosa infected with H. pylori.
  6. pmc Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)
    John L Wallace
    Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Br J Pharmacol 159:1236-46. 2010
    ..We evaluated the gastrointestinal safety and anti-inflammatory efficacy of a novel hydrogen sulphide-releasing derivative of naproxen, ATB-346 [2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester]...
  7. ncbi Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats
    Wei Zhao
    Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Acta Biochim Biophys Sin (Shanghai) 41:301-8. 2009
    ..Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway...
  8. doi Host-bacterial interactions in Helicobacter pylori infection
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 134:306-23. 2008
    ..pylori are spiral-shaped gram-negative bacteria with polar flagella that live near the surface of the human gastric mucosa. They have evolved intricate mechanisms to avoid the bactericidal acid in the gastric lumen and to survive ..
  9. doi Redox biology and gastric carcinogenesis: the role of Helicobacter pylori
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 16:1-7. 2011
    ..Understanding the molecular mechanism of H. pylori-induced carcinogenesis is important for developing new strategies against gastric cancer...
  10. ncbi Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats
    S Q Wasman
    Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Teknologi Malaysia, 81310, UTM Skudai, Johor, Malaysia
    Indian J Exp Biol 49:767-72. 2011
    ..65. Results of this study showed that pretreatment with ethonolic extract of A. paniculata ethanolic provided significant protection against gastric ulcer by regulating of pH, mucous production and antioxidant property...
  11. ncbi Comparison between magnifying endoscopy and histological, culture and urease test findings from the gastric mucosa of the corpus
    K Yagi
    Department of Internal Medicine, Niigata Prefectural Yoshida Hospital, Japan
    Endoscopy 34:376-81. 2002
    ..In a previous study, the endoscopic features and a magnified view of the gastric mucosa of the corpus of H. pylori-negative normal stomach were described...
  12. doi Topographic differences in gastric micromucosal patterns observed by magnifying endoscopy with narrow band imaging
    Masashi Kawamura
    Department of Gastroenterology, JR Sendai Hospital, Miyagi, Japan
    J Gastroenterol Hepatol 26:477-83. 2011
    ..The aim of this study was to investigate the differences in distributions of gastric micromucosal structures observed by magnifying narrow band imaging (NBI) endoscopy among patients with different H. pylori-associated diseases...
  13. pmc Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    John Y Kao
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
    Gastroenterology 138:1046-54. 2010
    ..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
  14. pmc Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health
    Freddy Haesebrouck
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Clin Microbiol Rev 22:202-23, Table of Contents. 2009
    Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans...
  15. pmc Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 300:1430-4. 2003
    ..CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions...
  16. ncbi Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa
    F Luzza
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Catanzaro, Italy
    J Immunol 165:5332-7. 2000
    ..inhibition of IL-8 secretion, indicating that IL-17 contributes to enhance IL-8 in the HP-colonized gastric mucosa. Consistently, stimulation of MKN 28 cells, a gastric epithelial cell line, with IL-17 increased IL-8 ..
  17. ncbi SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Science 295:683-6. 2002
    ..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2...
  18. ncbi Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice
    L E Smythies
    Department of Medicine, Pathology, and Comparative Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 165:1022-9. 2000
    ..pylori infection and demonstrate that up-regulated production of IFN-gamma, in the absence of the opposing effects of IL-4 (and possibly IL-10), plays a pivotal role in promoting H. pylori-induced mucosal inflammation...
  19. doi Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?
    John L Wallace
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    Physiol Rev 88:1547-65. 2008
    ....
  20. doi SPARC is associated with gastric cancer progression and poor survival of patients
    Zhong sheng Zhao
    Departments of Pathology and Surgery, Zhejiang Provincal People s Hospital, Hangzhou, Zhejiang, People s Republic of China
    Clin Cancer Res 16:260-8. 2010
    ..The present study investigated the clinical significance of secreted protein, acidic and rich in cysteine (SPARC), in the development and progression of gastric cancer...
  21. doi Correlation between narrow band imaging and nonneoplastic gastric pathology: a pilot feasibility trial
    Ajay Bansal
    Department of Gastroenterology and Pathology, University of Kansas School of Medicine, Kansas City, Missouri, USA
    Gastrointest Endosc 67:210-6. 2008
    ..A novel narrow band imaging (NBI) system is able to visualize the mucosal and vascular network in the GI tract...
  22. doi Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Gastrointest Endosc 70:246-53. 2009
    ..Magnifying narrow-band imaging (NBI) endoscopy clearly visualizes superficial gastric mucosal patterns and capillary patterns...
  23. ncbi Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
    ....
  24. ncbi Clinical outcomes of EMR for gastric tumors: historical pilot evaluation between endoscopic submucosal dissection and conventional mucosal resection
    Kenichiro Watanabe
    Department of Internal Medicine, Radiology, Pathology, Saga Prefectural Hospital Koseikan, Saga Japan
    Gastrointest Endosc 63:776-82. 2006
    ..EMR is currently a standard treatment for mucosal gastric tumors. Endoscopic submucosal dissection (ESD) has been developed for en bloc resection...
  25. doi Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development
    Xavier Sagaert
    Department of Pathology, University Hospitals of K U Leuven, Minderbroederstraat 12, B 3000 Leuven, Belgium
    Nat Rev Gastroenterol Hepatol 7:336-46. 2010
    ....
  26. doi Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion
    Thiago M Moraes
    Sao Paulo State University, Department of Physiology, Rubiao Junior, CP 510, CEP 18618 000, Botucatu, Sao Paulo, Brazil
    Chem Biol Interact 180:499-505. 2009
    ..aurantium (OEC) and its majority compound limonene (LIM) to evaluate their effect on gastric mucosa. The OEC (250 mg/kg, p.o.) and LIM (245 mg/kg, p.o...
  27. pmc Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen
    Wei Guang
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Biol Chem 285:20547-57. 2010
    Helicobacter pylori infection of the gastric mucosa causes an active-chronic inflammation that is strongly linked to the development of duodenal and gastric ulcers and stomach cancer...
  28. doi Gastric carcinogenesis and the cancer stem cell hypothesis
    Yoshiro Saikawa
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Gastric Cancer 13:11-24. 2010
    ..NSCs in the normal gastric mucosa are thought to be present in the proliferative zone of the neck/isthmus region, and to undergo a complex ..
  29. pmc Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells
    Emma C Skoog
    Mucosal Immunobiology and Vaccine Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e36378. 2012
    Helicobacter pylori colonizes the mucus niche of the gastric mucosa and is a risk factor for gastritis, ulcers and cancer. The main components of the mucus layer are heavily glycosylated mucins, to which H. pylori can adhere...
  30. doi Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa
    Nicole Wittschier
    University of Munster, Institute for Pharmaceutical Biology and Phytochemistry, Hittorfstrasse 56, D 48149 Munster, Germany
    J Ethnopharmacol 125:218-23. 2009
    ..Additionally the influence of Glycyrrhiza glabra secondary compounds on the bacterial adhesion of Porphyromonas gingivalis, a major pathogen for induction of periodontal inflammations was to be investigated...
  31. ncbi Gastro-duodenal lesions and Helicobacter pylori infection in uremic patients and renal transplant recipients
    H Khedmat
    Baqyiatallah Research Center for Gastroenterology and Liver Diseases, Department of Internal Medicine, Baqyiatallah University of Medical Sciences, Tehran, Iran
    Transplant Proc 39:1003-7. 2007
    ..Upper gastrointestinal (UGI) symptoms are common in uremic patients, and higher serum levels of urea have been suggested to be related to Helicobacter pylori (HP) colonization and UGI mucosal inflammation...
  32. pmc Regulation of IL-18 in Helicobacter pylori infection
    Kazuyoshi Yamauchi
    Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 180:1207-16. 2008
    ..pylori-infected epithelial cells and monocytes. IL-18 levels in H. pylori-infected gastric mucosa were well correlated with the severity of gastric inflammation, confirming that H...
  33. doi Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model
    Masaharu Mita
    Laboratory Animal Research Center, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G877-84. 2008
    ..These results suggest that MT in the gastric mucosa might play an important role in the protection against H. pylori-induced gastric ulceration.
  34. pmc Time-series gene expression profiles in AGS cells stimulated with Helicobacter pylori
    Yuan Hai You
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PO Box 5, Changping District, Beijing 102206, China
    World J Gastroenterol 16:1385-96. 2010
    ..To extend the knowledge of the dynamic interaction between Helicobacter pylori (H. pylori) and host mucosa...
  35. doi Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats
    Sang Woon Park
    Digestive Disease Center and DMC MECOX Biomedical Research Center, Jesaeng Hospital, Seongnam, Korea
    J Gastroenterol Hepatol 23:976-84. 2008
    ....
  36. pmc BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity
    Nozomi Ishijima
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 286:25256-64. 2011
    ..pylori can exploit BabA-Le(b) binding to trigger TFSS-dependent host cell signaling to induce the transcription of genes that enhance inflammation, development of intestinal metaplasia, and associated precancerous transformations...
  37. doi Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers
    Masafumi Nishino
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Clin Pharmacol 51:1079-86. 2011
    ..In this 7-day study, lansoprazole appeared to be more protective than famotidine against low-dose aspirin-induced mucosal injury but a larger well-controlled study is necessary to establish a definitive clinical benefit...
  38. pmc IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
    Shui Ping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    Cancer Res 71:4247-59. 2011
    ..It is upregulated in the gastric mucosa by chronic Helicobacter infection; however, whether it plays a positive or negative role in inflammation-..
  39. ncbi Epidemiology and clinical presentation of stress-related peptic damage and chronic peptic ulcer
    Rok Seon Choung
    Dyspepsia Center and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Florida, USA
    Curr Mol Med 8:253-7. 2008
    ..Therefore, our objective is to provide an overview of the epidemiology and clinical presentation of stress-related peptic damage, in order to shed insights into the current understanding of the pathophysiology and treatment...
  40. doi Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression
    Yong Park
    Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, Korea University, Guro Hospital, 80 Guro dong, Guro Gu, Seoul, 152 703, Korea
    Med Oncol 27:1192-9. 2010
    ..008). Immunohistochemical stain showed the specific expression of BMP-2 in cancer cells compared with normal gastric mucosa. In conclusion, serum BMP-2 is associated with progression from early localized gastric cancer to locally ..
  41. doi Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs
    Neville D Yeomans
    School of Medicine, University of Western Sydney, Penrith South DC, NSW 1797, Australia
    Curr Med Res Opin 25:2785-93. 2009
    ..This was a narrative, descriptive review, rather than a formal systematic review...
  42. ncbi Gastric antisecretory and antiulcer effects of simvastatin in rats
    Mohammad Tariq
    Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia
    J Gastroenterol Hepatol 22:2316-23. 2007
    ..This investigation aimed to study the effect of SIM on experimentally induced gastric acid secretion and ulcer formation...
  43. pmc β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia
    Toni A Nagy
    Division of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Gastroenterology 141:553-64. 2011
    Colonization of gastric mucosa by Helicobacter pylori leads to epithelial hyperproliferation, which increases the risk for gastric adenocarcinoma...
  44. pmc Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells
    Jana N Radin
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
    Infect Immun 79:2535-43. 2011
    ....
  45. pmc Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases
    Hiroaki Ogiwara
    Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center 111D, Rm 3A 320, 2002 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Microbiol 47:3493-500. 2009
    ..pylori strains could be an improved predictor of histological inflammation and the potential for atrophy compared with the presence of the vacA s-, m-, and i-region genotypes in Western countries...
  46. doi Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer
    Masaaki Kobayashi
    Department of Endoscopy, Niigata University Medical and Dental Hospital, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    J Gastroenterol 46:1064-70. 2011
    ..However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP...
  47. doi Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video)
    Quan lin Li
    Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China
    Gastrointest Endosc 75:1153-8. 2012
    ..Endoscopic submucosal dissection (ESD) has been used successfully for the removal of esophageal or gastric SMTs; however, the EGJ has been regarded as a difficult location for ESD because of its narrow lumen and sharp angle...
  48. doi Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    J Biol Chem 283:14391-401. 2008
    ..that lansoprazole activates vascular epidermal growth factor-mediated controlled angiogenesis to repair gastric mucosa. Lansoprazole also stimulates the healing of already formed ulcers induced by indomethacin...
  49. pmc Role of innate immunity in Helicobacter pylori-induced gastric malignancy
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232 2279, USA
    Physiol Rev 90:831-58. 2010
    ..pylori-infected individuals who can then be targeted for therapeutic intervention...
  50. doi What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori
    Steffen Backert
    University College Dublin, School of Biomolecular and Biomedical Sciences, Belfield Campus, Dublin 4, Ireland
    Trends Microbiol 18:479-86. 2010
    ..Here we discuss the pros and cons of the multiple signaling activities in the induction of proinflammatory responses and associated problems, and give suggestions for finding ways out of this dilemma...
  51. ncbi Gene expression profiling in human gastric mucosa infected with Helicobacter pylori
    Véronique J Hofman
    Faculty of Medicine, Inserm ERI 21, Nice Cedex, France
    Mod Pathol 20:974-89. 2007
    ..were selected for the presence of chronic active gastritis, in absence of metaplasia and dysplasia of the gastric mucosa. Infected antral and fundic biopsies exhibited distinct transcriptional responses...
  52. ncbi The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment
    M Stolte
    Department of Pathology, Klinikum Bayreuth, Preuschwitzerstrasse 101, 95445 Bayreuth, Germany
    Can J Gastroenterol 15:591-8. 2001
    ....
  53. ncbi Smoking and the pathogenesis of gastroduodenal ulcer--recent mechanistic update
    Pallab Maity
    Department of Physiology, Indian Institute of Chemical Biology, Kolkata, India
    Mol Cell Biochem 253:329-38. 2003
    ..Nicotine also decreases prostaglandin generation in the gastric mucosa of smokers, thereby making the mucosa susceptible to ulceration...
  54. pmc Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcome
    Saori Fujimoto
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 5:49-58. 2007
    ..The blood grou...
  55. doi Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands
    Annemarie C de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 134:945-52. 2008
    ..Quantification of gastric cancer risk in patients with premalignant gastric lesions is unclear, however. Consequently, endoscopic surveillance is controversial, especially in Western populations...
  56. pmc MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS Pathog 5:e1000617. 2009
    ..pylori infected mice. Thus, MUC1 protects the epithelium from non-MUC1 binding bacteria by inhibiting adhesion to the cell surface by steric hindrance, and from MUC1-binding bacteria by acting as a releasable decoy...
  57. doi Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
    K Robinson
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
    Gut 57:1375-85. 2008
    ..To address the hypothesis that the human acquired immune response to H. pylori influences pathogenesis, we characterised the gastric T helper (Th) and regulatory T cell (Treg) response of infected patients...
  58. pmc Comparison of five PCR methods for detection of Helicobacter pylori DNA in gastric tissues
    J J Lu
    Division of Clinical Pathology, Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    J Clin Microbiol 37:772-4. 1999
    ..The results of this study indicate that of the five PCR methods examined, the ureC (glmM) gene PCR is the most sensitive and specific for the detection of H. pylori in gastric biopsy specimens...
  59. doi Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy
    Pharmacol Res 59:90-100. 2009
    ....
  60. ncbi Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization
    Tomokazu Mizuno
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 11:6305-11. 2005
    ..To determine the role of interleukin (IL)-17 in gastric ulcerogenesis...
  61. doi MicroRNA signatures in Helicobacter pylori-infected gastric mucosa
    Kayoko Matsushima
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
    Int J Cancer 128:361-70. 2011
    ..microRNA (miRNA), a non-coding RNA that controls gene expression mainly through translational repression, in gastric mucosa infected with Helicobacter pylori. Using endoscopic biopsy specimens, miRNA expression patterns in H...
  62. ncbi Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: role of endogenous sulphydryls and nitric oxide
    Hélio Kushima
    Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista UNESP, Botucatu, CP 510, CEP 18608 000, Botucatu, Sao Paulo, Brazil
    J Ethnopharmacol 101:61-7. 2005
    ..By comparative effect (intraduodenal and oral route), we observed that HAE was better for local activity in gastric mucosa than in systemic action...
  63. ncbi Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues
    T Kobayashi
    Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University, Nagoya, Aichi, 454-8509, Japan
    Pharmacol Res 43:23-30. 2001
    ..teprenone administration caused a decrease in MPO activity and an increase in adherent mucus content in the gastric mucosa of the intact region...
  64. pmc IL-17 is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse model
    Satoshi Shiomi
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Helicobacter 13:518-24. 2008
    ..In this study, the contributions of IL-17 to the induction of gastric inflammation and to the protection from H. pylori infection were investigated using IL-17 gene-knockout (IL-17(-/-)) mice...
  65. ncbi Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin C
    T Pohle
    Department of Medicine B, University of Munster, Munster, Germany
    Aliment Pharmacol Ther 15:677-87. 2001
    ..The roles of active oxygen metabolites and anti-oxidative defenses in aspirin (ASA)-induced gastric damage have been little studied...
  66. pmc A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection
    M A Poles
    Department of Medicine, UCLA School of Medicine, UCLA Center for HIV and Digestive Diseases, Los Angeles, California 90095, USA
    J Virol 75:8390-9. 2001
    ..We conclude that, based on these findings, the gastrointestinal mucosa represents a favored target for HIV-1, in part due to its large population of CXCR4(+) CCR5(+) target cells and not to differences in the virus that it contains...
  67. pmc Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo
    G Graziani
    Dipartimento di Scienza degli Alimenti, Universita di Napoli, Italy
    Gut 54:193-200. 2005
    ..Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa...
  68. pmc Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries
    Y Yamaoka
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 37:2274-9. 1999
    ..iceA status shows considerable geographic differences, and neither iceA nor combinations of iceA, vacA, and cagA were helpful in predicting the clinical presentation of an H. pylori infection...
  69. doi Runx3 expression in gastrointestinal tract epithelium: resolving the controversy
    K Ito
    Institute of Molecular and Cell Biology, Proteos, Singapore
    Oncogene 28:1379-84. 2009
    ..G-poly primarily recognizes the region beyond 234 and hence, is unable to detect Runx3 in this tissue...
  70. pmc Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milan, Italy
    Br J Pharmacol 154:688-97. 2008
    Ghrelin, a gut-brain peptide, is considered a gastroprotective factor in gastric mucosa. We investigated the role of prostaglandins (PG) and the possible interplay between PGs and nitric oxide (NO) in ghrelin gastroprotection against ..
  71. ncbi Luminal amino acid sensing in the rat gastric mucosa
    Hisayuki Uneyama
    Physiology and Nutrition Group, Institute of Life Sciences, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G1163-70. 2006
    ..Altogether, these results strongly suggest the existence of a sensing system for glutamate in the rat gastric mucosa. Thus luminal glutamate would enhance the electrophysiological firing rate of afferent fibers from the vagus ..
  72. doi Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?
    Ebru Turkkan
    Department of Internal Medicine, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
    J Gastroenterol 44:66-70. 2009
    ..In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia...
  73. doi Exfoliation of gastric pit-parietal cells into the gastric lumen associated with a stimulation of isolated rat gastric mucosa in vitro: a morphological study by the application of cryotechniques
    Fumiyo Aoyama
    Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan
    Histochem Cell Biol 129:785-93. 2008
    ..In a rat gastric mucosa isolated after stimulation, a number of cells were exfoliated into the gastric lumen of the pit region...
  74. ncbi Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
    The real mechanism of adaptive cytoprotection in the gastric mucosa is not well established...
  75. pmc Successful antibiotic treatment of Helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphomas
    M Raderer
    Department of Medicine I, Division of Oncology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gut 55:616-8. 2006
    The role of antibiotic treatment in early stage gastric mucosa associated lymphoid tissue (MALT) lymphoma not associated with Helicobacter pylori infection has not been investigated.
  76. pmc Roles of alpha and beta carbonic anhydrases of Helicobacter pylori in the urease-dependent response to acidity and in colonization of the murine gastric mucosa
    Stéphanie Bury-Moné
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 76:497-509. 2008
    ..mice were infected by SS1 Delta(beta-CA-HP) or by a SS1 double CA mutant, the inflammation scores of the mouse gastric mucosa were strongly reduced. In conclusion, CA contribute to the urease-dependent response to acidity of H...
  77. pmc Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 139:1686-98, 1698.e1-6. 2010
    ..We determined if spermine inhibits iNOS-mediated immunity by reducing L-Arg uptake into macrophages...
  78. pmc Ghrelin and Helicobacter pylori infection
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    World J Gastroenterol 14:6327-33. 2008
    ..mass index, plasma ghrelin concentration, gastric ghrelin mRNA, and the number of ghrelin producing cells in gastric mucosa are significantly lower in H pylori infected subjects than in H pylori-negative controls...
  79. ncbi Gastroprotection by vitamin C--a heme oxygenase-1-dependent mechanism?
    Jan C Becker
    Department of Medicine B, University of Munster, Munster, Germany
    Biochem Biophys Res Commun 312:507-12. 2003
    ....
  80. ncbi Cellular and molecular mechanisms of gastrointestinal ulcer healing
    Andrzej S Tarnawski
    Department of Medicine, VA Long Beach Healthcare System Long Beach, Long Beach, California 90822, USA
    Dig Dis Sci 50:S24-33. 2005
    ..Future directions to accelerate and improve healing include the use of stem cells and tissue engineering...
  81. ncbi Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi, Japan 329 0498
    J Clin Endocrinol Metab 90:10-6. 2005
    ..pylori-negative subjects. The expression levels of ghrelin mRNA and ghrelin-producing cells in the gastric mucosa were quantified with real-time quantitative RT-PCR and immunohistochemistry, respectively...
  82. ncbi Expression of a 31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary and metastatic gastric carcinomas
    R Lotan
    Department of Tumor Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Int J Cancer 56:474-80. 1994
    ....
  83. ncbi Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine
    Masaru Odashima
    First Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
    Dig Dis Sci 47:2799-804. 2002
    ..inducible HSP70), which is known as an endogenous cytoprotectant in a wide variety of cells, including rat gastric mucosa in vitro and in vivo...
  84. ncbi Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection
    Il Ran Hwang
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:1793-803. 2002
    ....
  85. ncbi Higher gastric cycloxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patients
    Bor Shyang Sheu
    Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan
    Clin Cancer Res 9:5245-51. 2003
    ..pylori eradication could reduce COX-2 expression...
  86. pmc Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion
    S P Cole
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Infect Immun 65:843-6. 1997
    ..Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells...
  87. ncbi EMR for early gastric cancer in Korea: a multicenter retrospective study
    Jae J Kim
    Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Gastrointest Endosc 66:693-700. 2007
    ..EMR has been accepted as a treatment modality for selected cases of early gastric cancer (EGC) in Japan. However, long-term outcomes after EMR for EGC have not been fully documented...
  88. pmc Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells
    Song Ze Ding
    Division of Gastroenterology and Hepatology, Department of Medicine, P O Box 800708, Charlottesville, VA 22908 0708, USA
    Infect Immun 75:4030-9. 2007
    ..pylori. These results indicate that bacterial factors and the host inflammatory response confer oxidative stress to the gastric epithelium during H. pylori infection that may lead to apoptosis...
  89. ncbi Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, 431 3192, Japan
    Cancer Epidemiol Biomarkers Prev 15:1929-34. 2006
    ..The aim of this study was to clarify the association of the chymase gene (CMA/B) and ACE polymorphisms with susceptibility to gastric cancer and peptic ulcer...
  90. ncbi Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein
    O Lefebvre
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, Communaute Urbaine de Strasbourg, France
    Science 274:259-62. 1996
    To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated...
  91. pmc The spatial orientation of Helicobacter pylori in the gastric mucus
    Sören Schreiber
    Institut fur Physiologie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Proc Natl Acad Sci U S A 101:5024-9. 2004
    ..H. pylori thus uses the gastric mucus pH gradient for chemotactic orientation...
  92. ncbi Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Cancer Sci 96:835-43. 2005
    ..pylori strains carrying biologically more active CagA are more virulent than those with less active CagA and are more closely associated with gastric carcinoma...
  93. ncbi Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cells
    Ji Hye Seo
    Department of Pharmacology and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Ann N Y Acad Sci 1096:29-36. 2007
    ..PAR-2 agonist peptide augmented H. pylori-induced COX-2 expression in AGS cells. H. pylori induces COX-2 expression, which is mediated by both activation and expression of PAR-2 in gastric epithelial cells...
  94. ncbi Eosinophil interactions with Haemonchus contortus larvae in the ovine gastrointestinal tract
    A Balic
    Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Victoria 3010, Australia
    Parasite Immunol 28:107-15. 2006
    ..In addition, they also suggest that effective killing by tissue eosinophils may depend on other microenvironmental factors such as intra-epithelial mast cells and IL-4...
  95. ncbi DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells
    Suck Chei Choi
    Digestive Disease Research Institute, Wonkwang University School of Medicine, Chonbuk, Korea
    World J Gastroenterol 12:4850-8. 2006
    ..To investigate whether, or how, DA-9601, which is a new gastroprotective agent, inhibits TNF-alpha-induced inflammatory signals in gastric epithelial AGS cells...
  96. pmc Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia
    Wataru Shibata
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 138:1022-34.e1-10. 2010
    ..We derived mice with a conditional knockout of IKKbeta in gastric epithelial cells (GECs) and myeloid cells, and examined responses to ionizing radiation (IR) and Helicobacter felis infection...
  97. ncbi The effect of Helicobacter felis and Helicobacter bizzozeronii on the gastric mucosa in Mongolian gerbils: a sequential pathological study
    M de Bock
    Departments of Pathology, Bacteriology and Avian Diseases, Faculty of Medicine, Ghent University, Belgium
    J Comp Pathol 135:226-36. 2006
    ..The mechanism by which H. felis induces PC necrosis and apoptosis remains unclear. The observed flagellar contact and NF-kappaB activation may play an important role in H. felis-associated inflammation...
  98. ncbi Gastroduodenal mucosal defense
    Amy Zhu
    West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 10:548-54. 2008
    ..This article also summarizes some new findings on the genetics of ulcer formation and the effects of age and gender on mucosal defense and touches on current developments in drugs, including considerations for future therapeutic agents...
  99. doi Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats
    Chun Ying Li
    Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, South Korea
    Alcohol 42:683-7. 2008
    ..These results suggest that the gastroprotective effect of C3G removes the ethanol-induced lipid peroxides and free radicals and that it may offer a potential remedy for the treatment of gastric lesions...
  100. doi Target molecules of molecular chaperone (HSP70 family) in injured gastric mucosa in vivo
    Michiro Otaka
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Life Sci 84:664-7. 2009
    ..In the present study, gastric mucosal proteins that specifically bind to the HSP70 family (HSC70) were analyzed using HSC70-affinity chromatography...
  101. ncbi Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cells
    Michiko Tanaka-Shintani
    Kobe University School of Medicine, Faculty of Health Sciences, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    J Gastroenterol 40:345-9. 2005
    ..We examined the distribution of ghrelin-immunoreactive cells in human gastric mucosa.

Research Grants78

  1. UREASE AND GENE EXPRESSION OF HELICOBACTER PYLORI
    HARRY MOBLEY; Fiscal Year: 2007
    ..This species, whose niche is highly restricted to the gastric mucosa of humans, has adopted a strategy of survival that includes synthesis of urease as its most abundant cellular ..
  2. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
    ..Our previous results are based on analysis of the whole gastric mucosa. Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric ..
  3. GASTRIC H+ ION TRANSPORT-CELLULAR CONTROL MECHANSIMS
    CATHERINE CHEW; Fiscal Year: 2005
    ..paracrines and growth factors interact to control hydrochloric acid secretion by parietal cells in the gastric mucosa. Gastroesophageal reflux and peptic ulcer disease are widespread clinical problems that result from or are ..
  4. Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
    Hartmut Luecke; Fiscal Year: 2010
    Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
  5. Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
    Hartmut Luecke; Fiscal Year: 2009
    Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
  6. Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
    Hartmut Luecke; Fiscal Year: 2009
    Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
  7. Acetone metabolism in Helicobacter pylori
    Timothy Hoover; Fiscal Year: 2004
    Helicobacter pylori is a major human pathogen that colonizes the gastric mucosa, leading to gastric inflammation that can progress to chronic gastritis, peptic ulcer, gastric cancer or mucosal-associated lymphoma. The ability of H...
  8. MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDES
    MICHAEL TRENT; Fiscal Year: 2006
    ..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
  9. Helicobacter pylori: Tactic Responses and Persistence in the Gastric Mucosa
    PAUL STOKES HOFFMAN; Fiscal Year: 2010
    ....
  10. Oxidative Injury to Gastric Epithelial Cells by H. pylori
    Sheila E Crowe; Fiscal Year: 2010
    ..Phagocytic leukocytes recruited to the gastric mucosa during infection become activated, generating reactive oxygen species (ROS) that alter gastric epithelial cell ..
  11. Oxidative Injury to Gastric Epithelial Cells by H. pylori
    Sheila Crowe; Fiscal Year: 2009
    ..Phagocytic leukocytes recruited to the gastric mucosa during infection become activated, generating reactive oxygen species (ROS) that alter gastric epithelial cell ..
  12. Helicobacter pylori: Tactic Responses and Persistence in the Gastric Mucosa
    Paul Hoffman; Fiscal Year: 2009
    ....
  13. Helicobacter pylori: Tactic Responses and Persistence in the Gastric Mucosa
    Paul Hoffman; Fiscal Year: 2007
    ..Understanding the fundamental mechanisms associated with acid survival and gastric colonization underpins all eradicative strategies from vaccines to novel therapeutics against a pathogen that infects half of the world's population. ..
  14. H.pylori arginase modulation of ulcers and cancer
    David McGee; Fiscal Year: 2007
    ..Polyamines (produced from ornithine) and arginase are elevated in the gastric mucosa of gastric cancer patients. Preliminary data demonstrate arginase is critical for H...
  15. MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDES
    MICHAEL TRENT; Fiscal Year: 2007
    ..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
  16. MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDES
    MICHAEL STEPHEN TRENT; Fiscal Year: 2010
    ..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
  17. MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDES
    MICHAEL TRENT; Fiscal Year: 2009
    ..Humans are the only significant reservoir for H. pylori, despite the hostile environment of the gastric mucosa. Therefore, a unique balance must be established in order to permit long-term survival of both the bacterium ..
  18. Bacterial and Chemical Carcinogens in Gastric Oncogenesis
    Andre Dubois; Fiscal Year: 2009
    ..H. pylori persists in the gastric mucosa of >50% of humans worldwide for the life of the host, despite intense immune and inflammatory responses, ..
  19. H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVES
    Douglas Berg; Fiscal Year: 2003
    ..Helicobacter pylori (Hp), one of the most genetically diverse of bacterial species, chronically infects the gastric mucosa of more than half of all persons world wide...
  20. UREASE AND GENE EXPRESSION OF HELICOBACTER PYLORI
    HARRY MOBLEY; Fiscal Year: 2003
    ..This species, whose niche is highly restricted to the gastric mucosa of humans, has adopted a strategy of survival that includes synthesis of urease as its most abundant cellular ..
  21. Nickel Metabolism in Helicobacter pylori
    Robert Maier; Fiscal Year: 2006
    Helicobacter pyori is a spiral bacterium that colonizes the gastric mucosa of humans, leading to a variety of gastric diseases that include peptic ulcers, chronic gastritis, mucosal-associated lymphomas, and adenocarcinomas of the lower ..