amnion

Summary

Summary: The innermost membranous sac that surrounds and protects the developing EMBRYO which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.

Top Publications

  1. ncbi Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells
    Ornella Parolini
    Centro di Ricerca E Menni, Fondazione Poliambulanza, Istituto Ospedaliero, Via Bissolati 57, 25124 Brescia, Italy
    Stem Cells 26:300-11. 2008
  2. ncbi Engraftment potential of human amnion and chorion cells derived from term placenta
    Marco Bailo
    Centro Ricerche Parco Scientifico E. Menni, Ospedale Poliambulanza, Via Romiglia, 4, I-25124 Brescia, Italy
    Transplantation 78:1439-48. 2004
  3. ncbi Stem cell characteristics of amniotic epithelial cells
    Toshio Miki
    Department of Pathology and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 23:1549-59. 2005
  4. ncbi Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair
    Yuben Moodley
    F R A C P School of Medicine and Pharmacology, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia
    Am J Respir Crit Care Med 182:643-51. 2010
  5. ncbi Immunosuppressive factors secreted by human amniotic epithelial cells
    Haochuan Li
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Invest Ophthalmol Vis Sci 46:900-7. 2005
  6. ncbi Stem cells derived from human fetal membranes display multilineage differentiation potential
    Sivakami Ilancheran
    Center for Women s Health Research, Department of Obstetrics and Gynecology, Monash University, Monash Medical Center, Clayton, Victoria 3168, Australia
    Biol Reprod 77:577-88. 2007
  7. ncbi Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis
    Anna Cargnoni
    Centro di Ricerca E Menni, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy
    Cell Transplant 18:405-22. 2009
  8. ncbi Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue
    Susanne Wolbank
    Red Cross Blood Transfusion Service of Upper Austria, Linz, Austria
    Tissue Eng 13:1173-83. 2007
  9. ncbi Isolation, characterization, and differentiation of stem cells derived from the rat amniotic membrane
    Akiva J Marcus
    The Ira B Black Center for Stem Cell Research, Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    Differentiation 76:130-44. 2008
  10. ncbi Comparative characterization of cultured human term amnion epithelial and mesenchymal stromal cells for application in cell therapy
    Grozdana Bilic
    Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
    Cell Transplant 17:955-68. 2008

Research Grants

  1. Cellular Mechanisms of Amniotic Fluid Volume Regulation
    Cecilia Y Cheung; Fiscal Year: 2010
  2. REGULATION OF VEGF EXPRESSION IN PLACENTA AND MEMBRANES
    CECILIA CHEUNG; Fiscal Year: 2004
  3. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
  4. MECHANISMS OF FETAL MEMBRANE RUPTURE
    JEROME STRAUSS; Fiscal Year: 2009
  5. MECHANISMS OF FETAL MEMBRANE RUPTURE
    JEROME STRAUSS; Fiscal Year: 2009
  6. Mouse Model For Amniotic Fluid Volume Regulation
    CECILIA CHEUNG; Fiscal Year: 2002
  7. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1991
  8. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
  9. The Molecular Pathogenesis of Health Disparities in Inf*
    Emmet Hirsch; Fiscal Year: 2005
  10. Fetal Membrane AQP Expression/Amniotic Fluid Regulation
    Michael Ross; Fiscal Year: 2004

Detail Information

Publications257 found, 100 shown here

  1. ncbi Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells
    Ornella Parolini
    Centro di Ricerca E Menni, Fondazione Poliambulanza, Istituto Ospedaliero, Via Bissolati 57, 25124 Brescia, Italy
    Stem Cells 26:300-11. 2008
    ....
  2. ncbi Engraftment potential of human amnion and chorion cells derived from term placenta
    Marco Bailo
    Centro Ricerche Parco Scientifico E. Menni, Ospedale Poliambulanza, Via Romiglia, 4, I-25124 Brescia, Italy
    Transplantation 78:1439-48. 2004
    ..which may entail progenitor potential. The immunologic reactivity and the transplantation potential of amnion and chorion cells, however, remain to be elucidated...
  3. ncbi Stem cell characteristics of amniotic epithelial cells
    Toshio Miki
    Department of Pathology and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 23:1549-59. 2005
    ..b>Amnion derived from term placenta after live birth may be a useful and noncontroversial source of stem cells for cell ..
  4. ncbi Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair
    Yuben Moodley
    F R A C P School of Medicine and Pharmacology, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia
    Am J Respir Crit Care Med 182:643-51. 2010
    ..Cellular therapies that could restore pneumocytes and reduce inflammation and fibrosis would be a major advance in management...
  5. ncbi Immunosuppressive factors secreted by human amniotic epithelial cells
    Haochuan Li
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Invest Ophthalmol Vis Sci 46:900-7. 2005
    ..Moreover, AEC supernatant inhibited macrophage migration in vitro. CONCLUSIONS: AECs secrete soluble factors that inhibit cells in both the innate and adaptive immune systems...
  6. ncbi Stem cells derived from human fetal membranes display multilineage differentiation potential
    Sivakami Ilancheran
    Center for Women s Health Research, Department of Obstetrics and Gynecology, Monash University, Monash Medical Center, Clayton, Victoria 3168, Australia
    Biol Reprod 77:577-88. 2007
    The amnion is the inner of two membranes surrounding the fetus. That it arises from embryonic epiblast cells prior to gastrulation suggests that it may retain a reservoir of stem cells throughout pregnancy...
  7. ncbi Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis
    Anna Cargnoni
    Centro di Ricerca E Menni, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy
    Cell Transplant 18:405-22. 2009
    Fetal membranes (amnion and chorion) have recently raised significant attention as potential sources of stem cells...
  8. ncbi Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue
    Susanne Wolbank
    Red Cross Blood Transfusion Service of Upper Austria, Linz, Austria
    Tissue Eng 13:1173-83. 2007
    ..All three cell types may be considered as possible alternatives to BMSCs for allogeneic application in tissue engineering...
  9. ncbi Isolation, characterization, and differentiation of stem cells derived from the rat amniotic membrane
    Akiva J Marcus
    The Ira B Black Center for Stem Cell Research, Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    Differentiation 76:130-44. 2008
    ..Similar to mesenchymal stem cells, these amnion-derived stem cells (ADSCs) express the surface markers CD29 and CD90, but were negative for the ..
  10. ncbi Comparative characterization of cultured human term amnion epithelial and mesenchymal stromal cells for application in cell therapy
    Grozdana Bilic
    Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
    Cell Transplant 17:955-68. 2008
    Emerging evidence suggests human amnion tissue as a valuable source of two distinct types of pluripotent cells, amnion epithelial cells (hAECs) and mesenchymal stromal cells (hAMSCs), for applications in cell replacement therapy...
  11. ncbi Human amniotic mesenchymal cells have some characteristics of cardiomyocytes
    Peng Zhao
    Department of Organ Regeneration, Institute of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Shinshu University School of Medicine, Matsumoto, Japan
    Transplantation 79:528-35. 2005
    ..CONCLUSION: The results of the present study suggest that hAMC possess some characteristics of cardiomyocytes...
  12. ncbi Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl₄-treated mice
    Ursula Manuelpillai
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Cell Transplant 19:1157-68. 2010
    ..To test this hypothesis we transplanted human amnion epithelial cells (hAEC), isolated from term delivered placenta, into immunocompetent C57/BL6 mice at week 2 of a 4-..
  13. ncbi Epidermal growth factor and interleukin-1beta utilize divergent signaling pathways to synergistically upregulate cyclooxygenase-2 gene expression in human amnion-derived WISH cells
    William E Ackerman
    Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine and Laboratory of Perinatal Research, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio 43210, USA
    Biol Reprod 71:2079-86. 2004
    ..It was previously demonstrated that EGF could potentiate IL-1beta-driven PGE(2) production in amnion and amnion-derived (WISH) cells...
  14. ncbi Identification of stem cell marker-positive cells by immunofluorescence in term human amnion
    Toshio Miki
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Reprod Immunol 75:91-6. 2007
    ..Stem cell marker-positive cells were found in amnion but not in choriodecidua, tissues known to contain hematopoietic and trophoblastic stem cells...
  15. ncbi Factors secreted by human amniotic epithelial cells promote the survival of rat retinal ganglion cells
    Saiko Uchida
    Department of Ophthalmology, Tokyo University School of Medicine, Tokyo 113-8655, Japan
    Neurosci Lett 341:1-4. 2003
    ..These results suggest that HAECs may produce unknown neuroprotective factors, suggesting its potential for the treatment of RGC degenerative diseases...
  16. ncbi Amniotic membrane and amniotic cells: potential therapeutic tools to combat tissue inflammation and fibrosis?
    U Manuelpillai
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Placenta 32:S320-5. 2011
    ....
  17. ncbi Role of human amniotic epithelial cell transplantation in spinal cord injury repair research
    V Sankar
    Department of Anatomy, Dr Arcot Lakshmanaswamy Mudaliar Postgraduate Institute of Basic Medical Sciences, Taramani Campus, University of Madras, 600 113, Chennai, India
    Neuroscience 118:11-7. 2003
    ..First, there was no evidence of immunological rejection probably due to the non-antigenic nature of the HAEC. Second, unlike neural tissue, procurement of HAEC does not involve many legal or ethical problems...
  18. ncbi Differentiation of mesenchymal cells derived from human amniotic membranes into hepatocyte-like cells in vitro
    Tomoharu Tamagawa
    Institute of Cell Biology, Ishiwata Hospital, RIKEN BioResource Centre, Ibaraki, Japan
    Hum Cell 20:77-84. 2007
    ..Although further studies should be carried out to determine whether such in vitro-differentiated cells can function in vivo as hepatocytes. These cells may be useful in various applications that require human hepatocytes...
  19. ncbi The potential of amniotic membrane/amnion-derived cells for regeneration of various tissues
    Ayaka Toda
    Department of Regenerative Medicine, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194 Japan
    J Pharmacol Sci 105:215-28. 2007
    ..It is of interest as a potential alternative to complicated tissue/organ transplantation. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attracted ..
  20. ncbi Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes
    Hiroko Tsuji
    Department of Obstetrics, Keio University School of Medicine, Tokyo, Japan
    Circ Res 106:1613-23. 2010
    ..Amniotic membrane is known to have the ability to transdifferentiate into multiple organs and is expected to stimulate a reduced immunologic reaction...
  21. ncbi Immunogenicity of human amniotic membrane in experimental xenotransplantation
    M Kubo
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 42:1539-46. 2001
    ..The immunogenic characterization of amniotic membrane is still unknown. This study was designed to examine the immunogenicity of human amniotic membrane, by using experimental xenotransplantation models...
  22. ncbi Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells
    Shogo Nagata
    Stem Cell Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Genes Cells 14:1395-404. 2009
    ..Here, we demonstrate that newborn human (h) and mouse (m) extra-embryonic amnion (AM) and yolk-sac (YS) cells, in which endogenous KLF4/Klf4, c-MYC/c-Myc and RONIN/Ronin are expressed, can be ..
  23. ncbi Human amniotic epithelial cells possess hepatocyte-like characteristics and functions
    Seiji Takashima
    Department of Organ Regeneration, Institutes of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    Cell Struct Funct 29:73-84. 2004
    ..In organ culture, the amnion secreted 30-fold larger amounts of albumin than human amniotic epithelial cells in monolayer culture...
  24. ncbi Transplanted human amniotic epithelial cells express connexin 26 and Na-K-adenosine triphosphatase in the inner ear
    Isamu Yuge
    Department of Otorhinolaryngology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Transplantation 77:1452-4. 2004
    ..This technology suggests the therapeutic potential for the treatment of hearing loss...
  25. ncbi Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4/SOX2/NANOG
    Hong xi Zhao
    Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, China
    Differentiation 80:123-9. 2010
    ..In this study, we tested whether human amnion-derived cells (hADCs) could be rapidly and efficiently reprogrammed into iPS cells by the defined factors: OCT4/..
  26. ncbi IL-1beta and IL-8 in human fetal membranes: changes with gestational age, labor, and culture conditions
    C L Elliott
    Institute of Obstetrics and Gynaecology, Imperial College School of Medicine, London, UK
    Am J Reprod Immunol 46:260-7. 2001
    ..This study aimed to characterize their concentrations in fetal membranes and any changes in these with advancing gestation and to define as to whether there are interactions between the membranes in their expression...
  27. ncbi Nuclear factor-kappa B is essential for up-regulation of interleukin-8 expression in human amnion and cervical epithelial cells
    C L Elliott
    Institute of Obstetrics and Gynaecology, Imperial College School of Medicine, Queen Charlotte s Hospital, Goldhawk Road, London W6 0XG, UK
    Mol Hum Reprod 7:787-90. 2001
    ..these sites to examine the relative importance of each site in IL-8 gene expression in a cervical cell line and in amnion cells obtained before and after labour...
  28. ncbi Apoptosis in the normal human amnion at term, independent of Bcl-2 regulation and onset of labour
    K Kumagai
    Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan
    Mol Hum Reprod 7:681-9. 2001
    This study was designed to detect apoptosis in the human amnion and to elucidate the signalling pathway involved in its regulation...
  29. ncbi Amniotic mesenchymal tissue cells inhibit dendritic cell differentiation of peripheral blood and amnion resident monocytes
    Marta Magatti
    Centro di Ricerca E Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy
    Cell Transplant 18:899-914. 2009
    ..We have previously shown that cells derived from the mesenchymal region of human amnion (AMTC) can strongly inhibit T-lymphocyte proliferation...
  30. ncbi Amniotic membrane and amniotic fluid-derived cells: potential tools for regenerative medicine?
    Ornella Parolini
    Centro di Ricerca E Menni, Fondazione Poliambulanza Istituto Ospedaliero, Via Bissolati, 57, 25124 Brescia, Italy
    Regen Med 4:275-91. 2009
    ....
  31. ncbi Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease mice
    Xiang Ying Kong
    Department of Pharmacology, School of Basic Medicine, Peking Union Medical College and Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing, 100005 China
    Brain Res 1205:108-15. 2008
    ..The results suggested that transplanted HACs could survive and promote the endogenous neurogenesis of mice, which maybe related to the increased level of neurotrophins of the striatum...
  32. ncbi Human amniotic epithelial cells ameliorate behavioral dysfunction and reduce infarct size in the rat middle cerebral artery occlusion model
    Tianjin Liu
    Genetic Engineering Group, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
    Shock 29:603-11. 2008
    ..This model holds tremendous potential for development into wide use in cell-mediated gene therapy in the future...
  33. ncbi Co-transplantation of bFGF-expressing amniotic epithelial cells and neural stem cells promotes functional recovery in spinal cord-injured rats
    Xiao ting Meng
    Department of Histology and Embryology, School of Bethune Medical Science, Jilin University, Changchun 130021, PR China
    Cell Biol Int 32:1546-58. 2008
    ..These findings suggest that a cograft of AECs/pLEGFP-hbFGF and NSCs may have benefits for SCI...
  34. ncbi Association of PAT proteins with lipid storage droplets in term fetal membranes
    W E Ackerman
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine and Laboratory of Perinatal Research, The Ohio State University, College of Medicine, Columbus, OH 43210, USA
    Placenta 28:465-76. 2007
    ..We found that large LDs of amnion epithelial cells were reactive for neutral lipid stains and simultaneously encoated with ADRP and TIP47, but not ..
  35. ncbi Characterization of immortalized human corneal endothelial cell line using HPV 16 E6/E7 on lyophilized human amniotic membrane
    Hyun Ju Kim
    Department of Ophthalmology, Chung Ang University Yongsan Hospital, Seoul, Korea
    Korean J Ophthalmol 20:47-54. 2006
    ..To establish the immortalized human corneal endothelial cell line (IHCEn) by transducing human papilloma virus (HPV) 16 E6/E7 oncogenes, and to identify their characteristics when cultivated on a lyophilized human amniotic membrane (LAM)...
  36. ncbi Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications
    Gita Pratama
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e26136. 2011
    ..These findings suggest that primary and expanded hAEC may be suitable for different cellular therapeutic applications...
  37. ncbi Phenotypic shift of human amniotic epithelial cells in culture is associated with reduced osteogenic differentiation in vitro
    G Stadler
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology AUVA Research Center, Linz Vienna, Austria
    Cytotherapy 10:743-52. 2008
    ....
  38. ncbi Production of hepatocyte-like cells from human amnion
    Toshio Miki
    Departments of Pathology and Surgery and McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA
    Methods Mol Biol 481:155-68. 2009
    ..Cells from the placental tissues such as amnion and chorion have been reported to display multilineage differentiation and surface marker and gene expression ..
  39. ncbi Role of glucocorticoid receptor and CCAAT/enhancer-binding protein alpha in the feed-forward induction of 11beta-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts
    Zhen Yang
    School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, People s Republic of China
    J Endocrinol 195:241-53. 2007
    ..We examined the molecular mechanisms of the feedback effect of cortisol on 11beta-HSD1 mRNA expression in human amnion fibroblasts...
  40. ncbi Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins
    I A Rooney
    Department of Medical Biochemistry, UWCM, Heath Park, Cardiff, U K
    Immunology 71:308-11. 1990
    ..Percentage cell lysis was markedly increased in the presence of Fab2 anti-CD59 and to a lesser, but significant, extent in the presence of Fab2 anti-DAF. Fab2 anti-MIP did not alter the sensitivity of the cells to lysis by complement...
  41. ncbi Inducing proliferation of human amniotic epithelial (HAE) cells for cell therapy
    S Terada
    Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Fukui University, Japan
    Cell Transplant 9:701-4. 2000
    Probably because amnion is derived from the fetus and is exposed to the maternal immune system, human amniotic epithelial (HAE) cells do not express the HLA-A, -B, -C, or -DR antigens on their surfaces, suggesting that HAE cells do not ..
  42. ncbi The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G
    J M Houlihan
    University of Bristol, Department of Obstetrics and Gynecology, St Michael s Hospital, UK
    J Immunol 154:5665-74. 1995
    The expression of HLA class I Ag by term human amnion epithelial cells was investigated...
  43. ncbi Interstitial collagen synthesis and processing in human amnion: a property of the mesenchymal cells
    M L Casey
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas, Southwestern Medical Center, Dallas 75235, USA
    Biol Reprod 55:1253-60. 1996
    This study was conducted to evaluate the ontogeny and cellular site of interstitial collagen formation in amnion, the tissue that provides the tensile strength of the human fetal membranes...
  44. ncbi Immunosuppressive properties of human amniotic membrane for mixed lymphocyte reaction
    M Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Exp Immunol 129:464-70. 2002
    ..These results indicate that human AM has the ability to suppress allo-reactive T cells in vitro. This inhibitory effect likely contributes to the success of the ALT-AMT combination...
  45. ncbi Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes
    Guadalupe Garcia Lopez
    Direction of Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
    Mol Hum Reprod 13:409-18. 2007
    ..the chorioamniotic membranes form two independent chambers, allowing for the selective stimulation of either the amnion (AMN) and/or the choriodecidua (CHD) regions...
  46. ncbi Biomechanical characterization of human amniotic membrane preparations for ocular surface reconstruction
    Roy S Chuck
    Department of Ophthalmology, University of California, Irvine, Calif, USA
    Ophthalmic Res 36:341-8. 2004
    ..To investigate the tensile and elastic properties of both commercially available and experimental human amniotic membrane preparations...
  47. ncbi Inducing proliferation of human amnion epithelial and mesenchymal cells for prospective engineering of membrane repair
    Nicole Ochsenbein-Kölble
    Unit of Perinatal Physiology, Department of Obstetrics, University Hospital, Zurich, Switzerland
    J Perinat Med 31:287-94. 2003
    ..approach to fetal membrane repair after premature rupture of the membranes (PROM) by characterizing the proliferation potential of human amnion epithelial and mesenchymal cells from preterm and term placenta in primary culture.
  48. ncbi On the origin of amniotic stem cells: of mice and men
    Mariya P Dobreva
    Laboratory of Developmental Signaling, Department of Molecular and Developmental Genetics, VIB, KU Leuven, Belgium
    Int J Dev Biol 54:761-77. 2010
    ..The amnion is the innermost extraembryonic membrane that eventually surrounds the fetus of amniotes, and contains the ..
  49. ncbi Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis
    Yeon Mee Kim
    Perinatology Research Branch, National Institute of Child Health and Human Development/NIH/DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 191:1346-55. 2004
    ..These observations have implications for understanding the biologic nature of innate immunity...
  50. ncbi Amnion-derived pluripotent/multipotent stem cells
    Toshio Miki
    Department of Pathology, University of Pittsburgh, 200 Lothrop, St. Pittsburgh, PA 15213, USA
    Stem Cell Rev 2:133-42. 2006
    ..In this review, we describe the unique characteristics of the AE stem cells and summarize previous work concerning the stem cell nature of cells from amnion.
  51. ncbi Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells
    Richard Allan Banas
    Stemnion, Inc, Pittsburgh, PA, USA
    Hum Immunol 69:321-8. 2008
    This is the first study on the immunologic properties of a clinically relevant population of cells derived from the amnion of human placenta...
  52. ncbi Properties of the amniotic membrane for potential use in tissue engineering
    Hassan Niknejad
    Department of Nanomedicine and Tissue Engineering, Shaheed Beheshti Medical University, Tehran, Iran
    Eur Cell Mater 15:88-99. 2008
    ..In this review, the various properties of the AM are discussed in light of their potential use for TE...
  53. ncbi Fetal stem cells from extra-embryonic tissues: do not discard
    Akiva J Marcus
    The Ira B Black Center for Stem Cell Research and the Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    J Cell Mol Med 12:730-42. 2008
    ..In this review we summarize recent work examining the plasticity and clinical potential of fetal stem cells isolated from extra-embryonic tissues...
  54. ncbi Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix
    S C Tseng
    Ocular Surface and Tear Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA
    J Cell Physiol 179:325-35. 1999
    ..It may also explain in part why fetal wound healing is scarless...
  55. ncbi Amniotic membrane transplantation for ocular surface reconstruction
    S C Tseng
    Ocular Surface and Tear Center, Bascom Palmer Eye Institute, William L McKnight Vision Research Pavillion, Miami, FL 33136, USA
    Biosci Rep 21:481-9. 2001
    The use of amniotic membrane (or amnion) for transplantation as graft in ocular surface reconstruction is reviewed...
  56. ncbi Basement membrane dissolution and reassembly by limbal corneal epithelial cells expanded on amniotic membrane
    Wei Li
    Ocular Surface Center and TissueTech, Inc, Miami, Florida 33173, USA
    Invest Ophthalmol Vis Sci 47:2381-9. 2006
    ..Thus, BM resynthesis may be used as another objective readout for assessing the success of ex vivo expansion of limbal epithelial progenitor cells on AM...
  57. ncbi Region-specific gene expression profiling: novel evidence for biological heterogeneity of the human amnion
    Yu Mi Han
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Reprod 79:954-61. 2008
    The amnion plays an important role during pregnancy and parturition. Though referred to as a single structure, this fetal tissue is regionally divided into placental amnion, reflected amnion, and umbilical amnion...
  58. ncbi Amnion-derived cellular cytokine solution (ACCS) promotes migration of keratinocytes and fibroblasts
    M Georgina Uberti
    Institute for Tissue Regeneration, Repair, and Rehabilitation, Bay Pines VA Healthcare System, Bay Pines, FL, USA
    Ann Plast Surg 64:632-5. 2010
    b>Amnion-derived Multipotent Progenitor cells appear to be useful as adjuvants in wound healing...
  59. ncbi Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities
    Marta Magatti
    Centro di Ricerca E Menni, Fondazione Poliambulanza, Istituto Ospedaliero, Via Bissolati 57, I 25124 Brescia, Italy
    Stem Cells 26:182-92. 2008
    ..In this study, we isolated cells from the mesenchymal region of amnion and identified two subpopulations discordant for expression of the HLA-DR, CD45, CD14, and CD86 cellular markers...
  60. ncbi Topical application of culture supernatant from human amniotic epithelial cells suppresses inflammatory reactions in cornea
    Kazutaka Kamiya
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Exp Eye Res 80:671-9. 2005
    ..These results suggest that HAEC are a source of soluble anti-inflammatory factors and that conditioned medium from HAEC contains factors other than IL-1ra that suppress corneal inflammation...
  61. ncbi Successful vitrification of human amnion-derived mesenchymal stem cells
    Jeong Hee Moon
    Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, 300 Gumi, Bundang, Seongnam, Gyeonggi 463 707, Korea
    Hum Reprod 23:1760-70. 2008
    A cryopreservation protocol for human amnion-derived mesenchymal stem cells (HAMs) is required because these cells cannot survive for long periods in culture...
  62. ncbi Reconstruction of ocular surface with heterologous limbal epithelium and amniotic membrane in a rabbit model
    M Avila
    Departamento de Oftalmologia, Facultad de Medicina, Hospital San Juan de Dios, Universidad Nacional de Colombia, Colombia
    Cornea 20:414-20. 2001
    ..To report in vivo reconstruction of the ocular surface using amniotic membrane and heterologous transplants of epithelial limbal cells in rabbits with chemical burns...
  63. ncbi Immunological characteristics of amniotic epithelium
    Junko Hori
    Department of Ophthalmology, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo 113 8602, Japan
    Cornea 25:S53-8. 2006
    ..We therefore suggest that immunogenicity of AE should not be ignored, and use of AM from different donor placentas should be emphasized when repeated AM transplantation is required in patients clinically...
  64. ncbi Prostaglandin H synthase-2 gene regulation in the amnion at labour: histone acetylation and nuclear factor kappa B binding to the promoter in vivo
    C M Mitchell
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, Australia
    Mol Hum Reprod 14:53-9. 2008
    Increased prostaglandin H synthase-2 (PGHS-2) expression in the amnion is critical for the production of prostaglandins that induce labour...
  65. ncbi Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels
    Erika A Bosman
    Department of Developmental Biology VIB7 for Biotechnology VIB and Laboratory of Molecular Biology Celgen, University of Leuven, B 3000 Leuven, Belgium
    Development 133:3399-409. 2006
    ..It is essential for primordial germ cell (PGC) development, for the development of the allantois and for amnion closure, as demonstrated by loss of Bmp signalling...
  66. ncbi Multilineage potential of side population cells from human amnion mesenchymal layer
    M Kobayashi
    Department of Regenerative Medicine, School of Allied Health Sciences, Kitasato University, Nishi hashimoto, Kanagawa, Japan
    Cell Transplant 17:291-301. 2008
    Side population (SP) cells were isolated by FACS from a human amnion mesenchymal cell (AMC) layer soon after enzyme treatment. The yield of SP cells from AMC layer (AMC-SP cells) was about 0.1-0.2%...
  67. ncbi The effect of mechanical stretch on cyclooxygenase type 2 expression and activator protein-1 and nuclear factor-kappaB activity in human amnion cells
    Aarthi R Mohan
    Imperial College London, Parturition Research Group, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
    Endocrinology 148:1850-7. 2007
    ..Uterine stretch also leads to stretch of the fetal membranes, including the amnion, an important source of prostaglandin E2 (PGE2)...
  68. ncbi Invasive pathway of Listeria ivanovii in human amnion-derived WISH cells
    M G Ammendolia
    Department of Technology and Health, National Institute of Health, Rome, Italy
    Int J Immunopathol Pharmacol 20:509-18. 2007
    ..monocytogenes. However, although L. ivanovii is capable of specifically infecting and replicating in human amnion cells, its survival in cytoplasm is limited compared to that of L. monocytogenes.
  69. ncbi Amniotic membrane use in ophthalmology
    Jose A P Gomes
    Advanced Ocular Surface Center, Brazil
    Curr Opin Ophthalmol 16:233-40. 2005
    ..The purpose of this review is to describe the most recent and relevant clinical and experimental data about the use of amniotic membrane in ophthalmology...
  70. ncbi Evidence for a spatial and temporal regulation of prostaglandin-endoperoxide synthase 2 expression in human amnion in term and preterm parturition
    Deug Chan Lee
    Perinatology Research Branch, National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, Maryland, 20892, and Detroit, Michigan, 48201, USA
    J Clin Endocrinol Metab 95:E86-91. 2010
    ..PTGS2 mRNA was found to be differentially expressed between placental amnion (amnion overlying the placental disc) and reflected amnion (amnion of the extraplacental chorioamniotic membranes) ..
  71. ncbi Amniotic membrane transplantation for conjunctival tumor
    Zhicong Chen
    Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
    Yan Ke Xue Bao 19:165-7, 145. 2003
    ..CONCLUSION: Preserved AMT is a very effective method to repair wound after giant conjunctival tumor operation. Complete removal of tumor and perfect fixation are the key of ocular surface reconstruction...
  72. ncbi A serum- and feeder-free technique of culturing human corneal epithelial stem cells on amniotic membrane
    Kaevalin Lekhanont
    Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Mol Vis 15:1294-302. 2009
    ..To describe a simple technique of cultivating human corneal epithelial stem cells using an Epilife culture medium under serum- and feeder-free conditions...
  73. ncbi Induced in vitro differentiation of pancreatic-like cells from human amnion-derived fibroblast-like cells
    Tomoharu Tamagawa
    Institute of Cell Biology, Ishiwata Hospital, Mito, Ibaraki, Japan
    Hum Cell 22:55-63. 2009
    There is growing evidence that the human amnion contains various types of stem cells. As amniotic tissue is readily available, it has the potential to be an important source of material for regenerative medicine...
  74. ncbi In situ immunolabeling allows for detailed localization of prostaglandin synthesizing enzymes within amnion epithelium
    W E Ackerman
    Laboratory of Perinatal Research, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, The Ohio State University, College of Medicine, Columbus, 43210, USA
    Placenta 27:919-23. 2006
    Detailed information regarding the subcellular distribution of proteins within amnion epithelial cells is a goal of numerous placental biologists...
  75. ncbi The persistence of transplanted amniotic membrane in corneal stroma
    Che J Connon
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Ophthalmol 141:190-2. 2006
    ..To characterize the long-term incorporation of transplanted amniotic membrane into corneal stroma...
  76. ncbi Decreased adherence and spontaneous separation of fetal membrane layers--amnion and choriodecidua--a possible part of the normal weakening process
    A Strohl
    Departments of Pediatrics, Case Western Reserve University CWRU, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    Placenta 31:18-24. 2010
    The fetal membrane (FM) layers, amnion and choriodecidua, are frequently noted to have varying degrees of separation following delivery. FM layers normally separate prior to rupture during in vitro biomechanical testing...
  77. ncbi Telomerase immortalized human amnion- and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics
    Susanne Wolbank
    Red Cross Blood Transfusion Service of Upper Austria, Linz, Austria
    Tissue Eng Part A 15:1843-54. 2009
    ..Sources such as adipose tissue and amnion offer outstanding possibilities for allogeneic transplantation due to their high differentiation potential and ..
  78. ncbi Separation of amnion from choriodecidua is an integral event to the rupture of normal term fetal membranes and constitutes a significant component of the work required
    Sunny Arikat
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA
    Am J Obstet Gynecol 194:211-7. 2006
    ..FM) rupture and to compare the biophysical properties of intact FM with its separated individual components (amnion and choriodecidua)...
  79. ncbi The use of amniotic membrane in reducing adhesions after strabismus surgery
    Hosam Sheha
    Research Institute of Ophthalmology, Cairo, Egypt
    J AAPOS 13:99-101. 2009
    ..Different techniques have been used with varying success to reduce these adhesions. We describe a novel surgical technique in which amniotic membrane is used to wrap the extraocular muscles...
  80. ncbi HOXC10 as a potential marker for discriminating between amnion- and decidua-derived mesenchymal stem cells
    Jong Ha Hwang
    Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
    Cloning Stem Cells 11:269-79. 2009
    ..HOXC10 was expressed in 10 of 10 amnion-derived MSCs but in only 2 of 10 decidua-derived MSCs...
  81. ncbi Effects of amniotic membrane suspension in human corneal wound healing in vitro
    Jin A Choi
    Department of Ophthalmology and Visual Science, Kangnam St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, ROK
    Mol Vis 15:2230-8. 2009
    ..To investigate the biochemical mechanism of amniotic membrane (AM) suspension on corneal wound healing, particularly on epithelial proliferation and migration...
  82. ncbi Characterization of the transcriptome of chorioamniotic membranes at the site of rupture in spontaneous labor at term
    Chia Ling Nhan-Chang
    Perinatology Research Branch, Intramural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 202:462.e1-41. 2010
    ..The purpose of this study was to compare the transcriptome between the site of membrane rupture and the chorioamniotic membranes away from the site of rupture...
  83. ncbi Amniochorion gelatinase-gelatinase inhibitor imbalance in vitro: a possible infectious pathway to rupture
    S J Fortunato
    Maternal Fetal Group and Perinatal Research Center of the Women s Health Research and Education Foundation and Aquinas College, Nashville, Tennessee 37203, USA
    Obstet Gynecol 95:240-4. 2000
    ..To estimate the effect of lipopolysaccharide on gelatinases and tissue inhibitors of matrix metalloproteinase 2 (gelatinase inhibitor) balance in human fetal membranes...
  84. ncbi Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera
    K Hanada
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Am J Ophthalmol 131:324-31. 2001
    ..To examine the efficacy of amniotic membrane transplantation in the treatment of deep corneal and scleral ulcers...
  85. ncbi Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia
    Stephan M Tanner
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Genet 33:426-9. 2003
    ..Mice homozygous with respect to the amn mutation generated by a transgene insertion have no amnion. The embryos are severely compromised, surviving to the tenth day of gestation but seem to lack the mesodermal ..
  86. ncbi Paradoxical proinflammatory actions of interleukin-10 in human amnion: potential roles in term and preterm labour
    Murray D Mitchell
    Liggins Institute, Department of Pharmacology, University of Auckland, Faculty of Medical and Health Sciences, Private Bag 92019, Auckland, New Zealand
    J Clin Endocrinol Metab 89:4149-52. 2004
    ..we have found that IL-10 does indeed exert anti-inflammatory properties in choriodecidua, but that in the adjacent amnion it has remarkable pro-inflammatory actions...
  87. ncbi Chorioamniotic membranes constitute a competent barrier to group b streptococcus in vitro
    N Kjaergaard
    Department of Obstetrics and Gynecology, Aalborg Hospital, Denmark
    Eur J Obstet Gynecol Reprod Biol 83:165-9. 1999
    ..To study the penetration of group B streptococcus (GBS) through human chorioamniotic membranes in vitro...
  88. ncbi [Application of amnion membrane transplantation combine with mitomycin C in the treatment of pterygium]
    Yixia Huang
    Shantou Center Hospital, Shantou 515031, China
    Yan Ke Xue Bao 20:74-6. 2004
    ..RESULT: Following up 6 to 18 months, the rate of recurrence is 3%. CONCLUSION: Applying amniotic membrane transplantation with mitomycin in operation can decrease pterygium recurrence, and no serious complication happens...
  89. ncbi Secretions of interleukin-1beta and tumor necrosis factor alpha by whole fetal membranes depend on initial interactions of amnion or choriodecidua with lipopolysaccharides or group B streptococci
    Veronica Zaga
    Biomedical Research Branch, Instituto Nacional de Perinatologia, Mexico City, Mexico
    Biol Reprod 71:1296-302. 2004
    ..the microbial insult using an in vitro experimental model that allowed testing of the individual contributions of amnion and choriodecidua to stimulation...
  90. ncbi Comparison of characteristics of cultured limbal cells on denuded amniotic membrane and fresh conjunctival, limbal and corneal tissues
    Hossein Baharvand
    Department of Stem Cells, Royan Institute, PO Box 19395 4644, Tehran, Iran
    Dev Growth Differ 49:241-51. 2007
    ..Also, the expression of traditional SC markers may not be a reliable indicator of limbal SC and there is an increasing need to determine factor(s) involved in their stemness...
  91. ncbi Differential gene expression in the amnion, chorion, and trophoblast of the human placenta
    C A Plouzek
    Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Placenta 14:277-85. 1993
    ..Immunocytochemical studies suggest that PSG and hCG are also present in the human amnion. In this study, we examined whether amniotic and chorionic membranes were capable of expressing trophoblastic-..
  92. ncbi Proteome analysis of human amnion and amniotic fluid by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Soo-Jin Park
    Department of Chemistry, Seoul National University, Gwanak-gu, Seoul, Korea 151-747
    Proteomics 6:349-63. 2006
    Proteome analysis by 2-DE and PMF by MALDI-TOF MS was performed on human amnion and amniotic fluid at term. Ninety-two soluble and nineteen membrane proteins were identified from amnion...
  93. ncbi Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency
    S C Tseng
    Ocular Surface and Tear Center, Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Fla 33136, USA
    Arch Ophthalmol 116:431-41. 1998
    ..To examine whether amniotic membrane transplantation (AMT), in preparing the perilimbal stroma, enhances the success of allograft limbal transplantation (ALT)...
  94. ncbi Identification of matrix metalloproteinase-9 in amniotic fluid and amniochorion in spontaneous labor and after experimental intrauterine infection or interleukin-1 beta infusion in pregnant rhesus monkeys
    Felipe Vadillo-Ortega
    Department of Research Direction and Electron Microscopy, , Mexico City, Mexico
    Am J Obstet Gynecol 186:128-38. 2002
    ..Immunocytochemistry localized matrix metalloproteinase-9 protein to amnion and chorion epithelial and mesenchymal cells and decidual stromal cells...
  95. ncbi A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes
    Toshio Fujimoto
    Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:6296-302. 2002
    ..We investigated whether this polymorphism is functionally significant for MMP-1 expression in amnion cells and whether it is associated with preterm premature rupture of the membranes (PPROM)...
  96. ncbi Reduction in corneal haze and apoptosis by amniotic membrane matrix in excimer laser photoablation in rabbits
    M X Wang
    Vanderbilt Laser Sight Center and Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8808, USA
    J Cataract Refract Surg 27:310-9. 2001
    ..To determine whether preserved human amniotic membrane can reduce corneal haze and keratocyte apoptosis induced by excimer laser photoablation in rabbit corneas...
  97. ncbi Functional and anatomic results of amnion vaginoplasty in young women with Mayer-Rokitansky-Küster-Hauser syndrome
    Christina Fotopoulou
    Department of Gynecology and Obstetrics, Charite, Campus Virchow Clinic, University Hospital, Berlin, Germany
    Fertil Steril 94:317-23. 2010
    ..To evaluate the surgical outcome and the long-term anatomic and functional results in young women with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH) undergoing neovaginal creation with amniotic membranes...
  98. ncbi A combined proteome and ultrastructural localization analysis of 14-3-3 proteins in transformed human amnion (AMA) cells: definition of a framework to study isoform-specific differences
    Jose M A Moreira
    Department of Proteomics in Cancer, Institute of Cancer Biology and Danish Centre for Translational Breast Cancer Research DCTB, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 7:1225-40. 2008
    ..subcellular localization of the 14-3-3 beta, epsilon, sigma, tau, and zeta protein isoforms in transformed human amnion (AMA) cells...
  99. ncbi Amnioinfusion in preterm PROM: effects on amnion and cord histology
    A Locatelli
    Department of Obstetrics and Gynecology, University of Milano Bicocca, Monza, Italy
    J Perinatol 28:97-101. 2008
    To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC).
  100. ncbi Development, validation and application of a two-site enzyme-linked immunosorbent assay for activin-AB
    L W Evans
    School of Biological and Molecular Sciences, Oxford Brookes University, UK
    J Endocrinol 153:221-30. 1997
    ..Activin-A was also found in the culture media from explants of human amnion, chorion, maternal decidua and placenta. In marked contrast, activin-AB was undetectable (< 0...
  101. ncbi Monochorionic diamniotic infants without twin-to-twin transfusion syndrome
    Leandro Cordero
    Division of Neonatal-Perinatal Medicine, Department of Pediatrics and Obstetrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210-1228, USA
    J Perinatol 25:753-8. 2005
    ..Although their perinatal mortality is low, the reported occurrence and the short- and long-term impacts of fetal and neonatal morbidities warrants attention...

Research Grants81

  1. Cellular Mechanisms of Amniotic Fluid Volume Regulation
    Cecilia Y Cheung; Fiscal Year: 2010
    ..These studies will be carried out in ovine amnion cells in vitro and chronically catheterized ovine fetuses in vivo...
  2. REGULATION OF VEGF EXPRESSION IN PLACENTA AND MEMBRANES
    CECILIA CHEUNG; Fiscal Year: 2004
    ..Recently, we found expression of vascular endothelial growth factor (VEGF) in the amnion and chorion, and this expression is increased under conditions of enhanced intramembranous absorption...
  3. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
    ..increases SERPINH1 promoter activity mitigating the effect of the 656 T allele;4) collagen synthesis is reduced in amnion fibroblasts carrying the 656 T allele, but not the 656 T allele in the presence of the 12 bp deletion;5) the ..
  4. MECHANISMS OF FETAL MEMBRANE RUPTURE
    JEROME STRAUSS; Fiscal Year: 2009
    ..SERPINH1 promoter activity mitigating the effect of the 656 T allele; 4) collagen synthesis is reduced in amnion fibroblasts carrying the 656 T allele, but not the 656 T allele in the presence of the 12 bp deletion; 5) the ..
  5. MECHANISMS OF FETAL MEMBRANE RUPTURE
    JEROME STRAUSS; Fiscal Year: 2009
    ..SERPINH1 promoter activity mitigating the effect of the 656 T allele; 4) collagen synthesis is reduced in amnion fibroblasts carrying the 656 T allele, but not the 656 T allele in the presence of the 12 bp deletion; 5) the ..
  6. Mouse Model For Amniotic Fluid Volume Regulation
    CECILIA CHEUNG; Fiscal Year: 2002
    ..This pathway is constituted by a network of microvessels on the surface of the placenta and, in sheep, within the amnion and chorion as well...
  7. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1991
    ..tumor cell degradation of the basement membrane or isolated components and/or 4) tumor cell invasion through the amnion basement membrane...
  8. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
    ..increases SERPINH1 promoter activity mitigating the effect of the 656 T allele;4) collagen synthesis is reduced in amnion fibroblasts carrying the 656 T allele, but not the 656 T allele in the presence of the 12 bp deletion;5) the ..
  9. The Molecular Pathogenesis of Health Disparities in Inf*
    Emmet Hirsch; Fiscal Year: 2005
    ..In the second phase of the project, we analyze human tissues (myometrium, placenta, chorion, amnion, decidua, amniocytes and blood) collected from approximately 1360 patients presenting in term and preterm labor in ..
  10. Fetal Membrane AQP Expression/Amniotic Fluid Regulation
    Michael Ross; Fiscal Year: 2004
    ..In situ hybridization reveals that AQP8 is expressed in epithelial cells of human amnion and chorion, as well as trophoblasts of placenta...
  11. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2007
    The amnion is a major site of PGE2 production during labor and is a rich source of arachidonic acid, the precursor of PG production...
  12. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
    The amnion is a major site of PGE2 production during labor and is a rich source of arachidonic acid, the precursor of PG production...
  13. OXIDATIVE DAMAGE AND PREMATURE RUPTURE OF THE MEMBRANES
    James Woods; Fiscal Year: 2004
    ..laboratory demonstrate that, in physiologic concentrations, the ROS, hypochlorous acid and superoxide, do damage amnion epithelium and collagen I, the strongest component of chorioamnion...
  14. In-ovo vaccination/avian influenza/bird/human
    DE CHU TANG; Fiscal Year: 2006
    ..Both vaccines will be injected into the amnion of chicken embryos...
  15. ENDOCRINE AND PARACRINE RELATIONSHIPS IN PARTURITION
    MILES NOVY; Fiscal Year: 2002
    ..Aim 2 will describe the presence of androgen and glucocorticoid receptors (ARs, GRs) in rhesus amnion, chorion, decidua, and myometrium at 80 and 100 percent of gestation using immunohistochemistry and ribonuclease ..
  16. HYPOXIA EFFECTS ON AMNIOTIC FLUID VOLUME
    ROBERT BRACE; Fiscal Year: 2007
    ..pathway will be determined by studying the effects of VEGF on transport in isolated amniotic membrane and amnion cells in culture...
  17. MECHANISMS OF FETAL MEMBRANE RUPTURE
    JEROME STRAUSS; Fiscal Year: 2005
    ..We will determine whether proteolytic fragments of fibronectin induce MMP expression in human amnion cells in vitro; define the receptor(s) and signal transduction cascade underlying this response; identify active ..