lymph nodes

Summary

Summary: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Top Publications

  1. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
  2. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
  3. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
  5. doi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
  6. pmc Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    Olga Schulz
    Institute of Immunology, Hannover Medical School, Hannover 30625, Germany
    J Exp Med 206:3101-14. 2009
  7. ncbi Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 450:110-4. 2007
  8. pmc Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes
    Madhav D Sharma
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Blood 113:6102-11. 2009
  9. pmc Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
    L Boring
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 100:2552-61. 1997
  10. ncbi CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003

Detail Information

Publications330 found, 100 shown here

  1. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
    ....
  2. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
    Primary T-cell responses in lymph nodes (LNs) require contact-dependent information exchange between T cells and dendritic cells (DCs)...
  3. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    ..Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network...
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..is required for B-cell migration to splenic follicles, but the requirements for homing to B-cell areas in lymph nodes remain to be defined...
  5. doi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
    ..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus...
  6. pmc Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    Olga Schulz
    Institute of Immunology, Hannover Medical School, Hannover 30625, Germany
    J Exp Med 206:3101-14. 2009
    ..lymph revealed that CD103(+) DCs, but not CX3CR1-expressing cells, migrate into the gut draining mesenteric lymph nodes (LNs) under steady-state and inflammatory conditions...
  7. ncbi Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 450:110-4. 2007
    b>Lymph nodes prevent the systemic dissemination of pathogens such as viruses that infect peripheral tissues after penetrating the body's surface barriers...
  8. pmc Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes
    Madhav D Sharma
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Blood 113:6102-11. 2009
    ..indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining lymph nodes (TDLNs), where it can potently activate Foxp3+ regulatory T cells (Tregs)...
  9. pmc Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
    L Boring
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 100:2552-61. 1997
    ..decrease in granuloma size accompanied by a dramatic decrease in the level of interferon gamma in the draining lymph nodes. Production of interferon gamma was also decreased in PPD-sensitized splenocytes from CCR2-/- mice and in naive ..
  10. ncbi CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
    ..Here, we demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(..
  11. pmc Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D Sharma
    Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 117:2570-82. 2007
    ..We hypothesize that IDO+ pDCs create a profoundly suppressive microenvironment within tumor-draining LNs via constitutive activation of Tregs...
  12. pmc Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes
    Claudia Jakubzick
    Department of Pediatrics at National Jewish Health, Denver, CO 80206, USA Integrated Department of Immunology, University of Colorado, Denver, CO 80206, USA Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 39:599-610. 2013
    ..Here we have shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs). Entry was unaffected in gnotobiotic mice...
  13. doi Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells
    Martin Guilliams
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 115:1958-68. 2010
    ..DC subtype and can be readily found in the skin and in the lungs as well as in their corresponding draining lymph nodes. The RA-producing skin-derived DCs were capable of triggering the generation of regulatory T cells, a finding ..
  14. pmc Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes
    Veronika Lukacs-Kornek
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Immunol 12:1096-104. 2011
    ..Notably, in vivo expression of NOS2 by FRCs and LECs regulated the size of the activated T cell pool. Our study elucidates an as-yet-unrecognized role for the lymph node stromal niche in controlling T cell responses...
  15. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    ..was injected subcutaneously, OVA protein was identified over a 4-48 h period in DCs, primarily in the lymph nodes draining the injection site...
  16. ncbi Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    M Skobe
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 7:192-8. 2001
    ..potently increased intratumoral lymphangiogenesis, resulting in significantly enhanced metastasis to regional lymph nodes and to lungs...
  17. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
    ..We conclude that lymphocyte egress is mediated by S1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target...
  18. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs)...
  19. ncbi Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..In dendritic cell therapy, in particular, delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system...
  20. ncbi Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    Alexander Link
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Nat Immunol 8:1255-65. 2007
    ..Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4(+) and CD8(+) T cell homeostasis by ..
  21. doi Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation
    Rieneke van de Ven
    Departments of Medical Oncology, VU University Medical Center Cancer Center Amsterdam, De Boelelaan, Amsterdam, The Netherlands
    Blood 118:2502-10. 2011
    ..study we identified and functionally tested 4 human conventional DC (cDC) subsets within skin-draining sentinel lymph nodes (SLNs) from early-stage melanoma patients...
  22. pmc Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
    Deepali Malhotra
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Immunol 13:499-510. 2012
    ..LNSCs from inflamed lymph nodes upregulated expression of genes encoding chemokines and molecules involved in the acute-phase response and the ..
  23. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..LCs were sessile under steady-state conditions, whereas skin inflammation induced LC motility and emigration to lymph nodes (LNs)...
  24. doi The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer
    Valerie W Rusch
    Thoracic Surgery Service, Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA
    J Thorac Oncol 4:568-77. 2009
    ..A method of grouping lymph node stations together into "zones" is also proposed for the purposes of future survival analyses...
  25. ncbi Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
    ..Here we show in mice that natural killer (NK) cells, which are normally excluded from lymph nodes, are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the ..
  26. ncbi Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
    Jordi C Ochando
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Nat Immunol 7:652-62. 2006
    ..Tolerizing pDCs acquired alloantigen in the allograft and then moved through the blood to home to peripheral lymph nodes. In the lymph node, alloantigen-presenting pDCs induced the generation of CCR4+ CD4+ CD25+ Foxp3+ regulatory T ..
  27. pmc Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    Elin Jaensson
    Immunology Section, BMC D14, 221 84 Lund University, Lund, Sweden
    J Exp Med 205:2139-49. 2008
    ..distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing ..
  28. pmc Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation
    Tri Giang Phan
    1 Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco UCSF, California, USA 2 Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    Nat Immunol 10:786-93. 2009
    ..Thus, we characterize SCS macrophages as specialized antigen-presenting cells functioning at the apex of an antigen transport chain that promotes humoral immunity...
  29. pmc IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    Irah L King
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 206:1001-7. 2009
    ..the IL-4-mediated link between Th2 cells and B lymphocytes, the location of IL-4-producing T cells in the lymph nodes is currently unclear...
  30. pmc Dynamics of neutrophil migration in lymph nodes during infection
    Tatyana Chtanova
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Immunity 29:487-96. 2008
    ..blood to sites of infection have been well characterized, little is known about their migration patterns within lymph nodes or the strategies that neutrophils use to find their local sites of action...
  31. pmc Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells
    Gretchen E Diehl
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 494:116-20. 2013
    ..of both commensal and pathogenic bacteria from the lumen to a key immune inductive site, the mesenteric lymph nodes (MLNs)...
  32. pmc Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes
    Richard Ting
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    Bioconjug Chem 21:1811-9. 2010
    ..Facile incorporation of (18)F into a NIRF probe should promote many synergistic PET and NIRF combinations...
  33. pmc Characterization of resident and migratory dendritic cells in human lymph nodes
    Elodie Segura
    Institut National de la Santé et de la Recherche Médicale Unité 932, 75005 Paris, France
    J Exp Med 209:653-60. 2012
    Dendritic cells (DCs) initiate adaptive immune responses in lymph nodes (LNs). In mice, LN DCs can be divided into resident and tissue-derived populations, the latter of which migrate from the peripheral tissues...
  34. pmc The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
    Peter T Sage
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:152-61. 2013
    ..Here we found that mice deficient in PD-1 and its ligand PD-L1 had a greater abundance of T(FR) cells in the lymph nodes and that those T(FR) cells had enhanced suppressive ability...
  35. doi Lymph node homing of T cells and dendritic cells via afferent lymphatics
    Reinhold Forster
    Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
    Trends Immunol 33:271-80. 2012
    ..and, in particular, their subsequent transmigration from afferent lymphatics into the parenchyma of draining lymph nodes (LNs)...
  36. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..Stimulation of CD8-expressing T cells by dendritic cells from Peyer's patches, peripheral lymph nodes and spleen induced equivalent activation markers and effector activity in T cells, but only Peyer's patch ..
  37. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..Lack of lymphatic growth exaggerated mucosal edema and reduced the hypertrophy of draining lymph nodes. Airway dendritic cells, macrophages, neutrophils, and epithelial cells expressed the VEGFR-3 ligands VEGF-C or ..
  38. pmc CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    Sergio A Quezada
    Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 116:1935-45. 2006
    ..Tumor challenge increased the frequency of Tregs in lymph nodes, and untreated tumors became infiltrated by CD4+Foxp3- and CD4+Foxp3+ T cells but few CD8+ T cells...
  39. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
    ..Blr1 mutant mice lack inguinal lymph nodes and possess no or only a few phenotypically abnormal Peyer's patches...
  40. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    ..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...
  41. pmc Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    Gabriel D Victora
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 143:592-605. 2010
    ..Thus, T cell help, and not direct competition for antigen, is the limiting factor in GC selection...
  42. pmc Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
    Shabaana A Khader
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 203:1805-15. 2006
    ..These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs...
  43. ncbi Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes
    Valérie Abadie
    Mycobacterial Genetics Unit, Institut Pasteur, 25 rue du Docteur Roux, 7724 Paris Cedex 15, France
    Blood 106:1843-50. 2005
    ..During the first 3 days, we tracked BCG host cells migrating out of the dermis to the auricular draining lymph nodes (ADLNs)...
  44. pmc VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
    Satoshi Hirakawa
    Cutaneous Biology Research Center, Department of Immunobiology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Blood 109:1010-7. 2007
    The mechanisms by which tumors metastasize to sentinel and distant lymph nodes, and beyond, are poorly understood...
  45. ncbi B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
    Yolanda R Carrasco
    Lymphocyte Interaction Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 27:160-71. 2007
    ..These observations not only provide evidence of a B cell role as antigen transporters into the follicle, but also highlight the boundary between the follicle and the SCS as a site for initiation of B cell responses...
  46. pmc Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization
    Denise M Monack
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Exp Med 199:231-41. 2004
    ..Here, we show that S. typhimurium can persist for as long as 1 yr in the mesenteric lymph nodes (MLNs) of 129sv Nramp1(+)(/)(+) (Slc11a1(+)(/)(+)) mice despite the presence of high levels of anti-S...
  47. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming...
  48. pmc Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions
    Anne L Fletcher
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 207:689-97. 2010
    ..Collectively, these data show that diverse stromal cell types have evolved to constitutively express PTAs, and that exposure to viral products alters the interaction between T cells and LNSCs...
  49. pmc Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
    Ramon Roozendaal
    Departments of Pediatrics and Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 30:264-76. 2009
    To track drainage of lymph-borne small and large antigens (Ags) into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic cells, we used the approach of multiphoton intravital microscopy...
  50. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    ..using B16-F10 melanoma cells implanted in syngeneic C57Bl/6 mice, which form tumors metastasizing to draining lymph nodes and subsequently to the lungs...
  51. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow...
  52. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  53. ncbi The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
    ..We have characterized human NK cells of spleen, lymph nodes, and tonsils...
  54. doi Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration
    Asolina Braun
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Nat Immunol 12:879-87. 2011
    ..By injecting cells directly into afferent lymph vessels of popliteal lymph nodes, we demonstrate that lymph-derived T cells entered lymph-node parenchyma mainly from peripheral medullary ..
  55. pmc Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    J Exp Med 197:1191-8. 2003
    ..established an important role for CXCL13 (BLC) in the development of Peyer's patches (PP) and some peripheral lymph nodes (LNs), but the chemokine requirements for several LN types, including mesenteric LNs, remain undefined...
  56. ncbi Mapping pelvic lymph nodes: guidelines for delineation in intensity-modulated radiotherapy
    Alexandra Taylor
    Department of Radiotherapy, St Bartholomew s Hospital, London, United Kingdom
    Int J Radiat Oncol Biol Phys 63:1604-12. 2005
    To establish guidelines for delineating the clinical target volume for pelvic nodal irradiation by mapping the location of lymph nodes in relation to the pelvic anatomy.
  57. pmc Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells
    H C Probst
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Clin Exp Immunol 141:398-404. 2005
    ..time points after diphtheria toxin injection and confirmed the transient depletion of CD11c+ cells from lymph nodes and spleen...
  58. doi Micrometastases or isolated tumor cells and the outcome of breast cancer
    Maaike de Boer
    Division of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands
    N Engl J Med 361:653-63. 2009
    The association of isolated tumor cells and micrometastases in regional lymph nodes with the clinical outcome of breast cancer is unclear.
  59. pmc Histologic identification of human papillomavirus (HPV)-related squamous cell carcinoma in cervical lymph nodes: a reliable predictor of the site of an occult head and neck primary carcinoma
    Samir K El-Mofty
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 2:163-8. 2008
    ..Identifying HPV-related SCC in the lymph nodes may thus provide a means for localizing the primary tumor site.
  60. doi Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    David S Cooper
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 19:1167-214. 2009
    ..Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines...
  61. ncbi CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes
    Myoung Ho Jang
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Immunol 176:803-10. 2006
    Although dendritic cells (DCs) located in the small intestinal lamina propria (LP-DCs) migrate to mesenteric lymph nodes (MLNs) constitutively, it is unclear which chemokines regulate their trafficking to MLNs...
  62. doi CCR7 essentially contributes to the homing of plasmacytoid dendritic cells to lymph nodes under steady-state as well as inflammatory conditions
    Sebastian Seth
    Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
    J Immunol 186:3364-72. 2011
    The chemokine receptor CCR7 represents an important determinant for circulating lymphocytes to enter lymph nodes (LN) via high endothelial venules...
  63. pmc IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation
    Sandra Bajana
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 189:3368-77. 2012
    Migration of resident dendritic cells (DC) from the skin to local lymph nodes (LN) triggers T cell-mediated immune responses during cutaneous infection, autoimmune disease, and vaccination...
  64. ncbi Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial
    Joseph Ragaz
    McGill University Health Center, Royal Victoria Hospital, 687 Pine Ave, Montreal, PQ, Canada H3A 1A1
    J Natl Cancer Inst 97:116-26. 2005
    ..We report the analysis of data from the 20-year follow-up...
  65. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
    ..here that CD4(+) follicular helper T cells constituted essentially all of the cytokine-secreting T cells in lymph nodes and were functionally distinct from T cells secreting the same cytokine in peripheral tissues...
  66. ncbi A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer
    Umberto Veronesi
    Division of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 349:546-53. 2003
    ..Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation...
  67. doi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  68. doi Lymph node ratio should be considered for incorporation into staging for breast cancer
    Anees B Chagpar
    Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    Ann Surg Oncol 18:3143-8. 2011
    ..We sought to determine whether lymph node ratio (LNR; defined as number of positive nodes/number of nodes dissected) provides additional prognostic information in node-positive breast cancer patients...
  69. pmc Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE
    D Kim
    Laboratory of Immunology, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 192:1467-78. 2000
    ..Thus, we propose that both TRANCE and LTalphabeta regulate the colonization and cluster formation by CD45(+) CD4(+)CD3(-) cells in developing LNs, the degree of which appears to correlate with the state of LN organogenesis...
  70. ncbi Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer
    Timothy M Pawlik
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Surgery 141:610-8. 2007
    ..Few studies have investigated the ratio of the number of lymph nodes harboring metastatic cancer to the total number of lymph nodes examined (lymph node ratio [LNR]) with regard to ..
  71. ncbi Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    H Suzuki
    Amgen Institute, Toronto, Ontario, Canada
    Science 268:1472-6. 1995
    ..Thus, IL-2R beta is required to keep the activation programs of T cells under control, to maintain homeostasis, and to prevent autoimmunity...
  72. ncbi Generation and analysis of interleukin-4 deficient mice
    R Kuhn
    Institute for Genetics, University of Cologne, Germany
    Science 254:707-10. 1991
    ..Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo...
  73. pmc Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer
    J Sven D Mieog
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg Oncol 18:2483-91. 2011
    ..Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers...
  74. pmc Regulation of lymph node vascular growth by dendritic cells
    Brian Webster
    Autoimmunity and Inflammation Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Exp Med 203:1903-13. 2006
    b>Lymph nodes grow rapidly and robustly at the initiation of an immune response, and this growth is accompanied by growth of the blood vessels...
  75. doi Expression of IFN-gamma, TNF-alpha, IL-10 and TGF-beta in lymph nodes associates with parasite load and clinical form of disease in dogs naturally infected with Leishmania (Leishmania) chagasi
    Cintia F Alves
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Vet Immunol Immunopathol 128:349-58. 2009
    ..work is first to report the profile of cytokines and parasite burdens, as determined by real-time PCR, in the lymph nodes of dogs naturally infected with Leishmania chagasi...
  76. doi Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules
    Christine Moussion
    CNRS, Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne, F 31077 Toulouse, France
    Nature 479:542-6. 2011
    ..the body in search of foreign antigens, naive lymphocytes continuously circulate from the blood, through the lymph nodes, into the lymphatic vessels and back to the blood...
  77. pmc Stromal cell contributions to the homeostasis and functionality of the immune system
    Scott N Mueller
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010 Victoria, Australia
    Nat Rev Immunol 9:618-29. 2009
    ..movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic regulation, peripheral tolerance and the effective ..
  78. pmc Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients
    Merlijn Hutteman
    Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Breast Cancer Res Treat 127:163-70. 2011
    ..With these optimized parameters that eliminate the necessity of HSA, larger trials can now be performed to determine patient benefit...
  79. ncbi Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    Yulong He
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Cancer Res 65:4739-46. 2005
    ..lymph node metastasis were significantly inhibited by VEGFR-3-Ig, some tumor cells were still detected in the lymph nodes in some of the treated mice...
  80. ncbi In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles
    Sai T Reddy
    Institute of Bioengineering, École Polytechnique Fédérale de Lausanne EPFL CH 1015 Lausanne, Switzerland
    J Control Release 112:26-34. 2006
    ..and 100nm diameter poly(ethylene glycol)-stabilized poly(propylene sulfide) (PPS) nanoparticles to DCs in the lymph nodes. These nanoparticles consist of a cross-linked rubbery core of PPS surrounded by a hydrophilic corona of poly(..
  81. ncbi A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy
    Kimberly J Van Zee
    Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg Oncol 10:1140-51. 2003
    ..Accurate estimates of the likelihood of additional disease in the axilla could assist greatly in decision-making regarding further treatment...
  82. ncbi Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection
    James B McLachlan
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 4:1199-205. 2003
    Palpable swelling of regional lymph nodes is a common sequela of microbial infections but the mechanism responsible for the sequestration and subsequent coordination of lymphocyte responses within these dynamic structures remains poorly ..
  83. ncbi Dendritic-cell trafficking to lymph nodes through lymphatic vessels
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, New York 10029, USA
    Nat Rev Immunol 5:617-28. 2005
    ..with naive T cells for the presentation of these antigens requires that the dendritic cells migrate to draining lymph nodes through lymphatic vessels...
  84. doi Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    Joshua L Hood
    Consortium for Translational Research in Advanced Imaging and Nanomedicine, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 71:3792-801. 2011
    ..In this study, we show exosome-mediated conditioning of lymph nodes and define microanatomic responses that license metastasis of melanoma cells...
  85. pmc Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses
    Hideki Nakano
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nat Immunol 10:394-402. 2009
    ..protection against intracellular pathogens, are thought to be initiated by dendritic cells (DCs) that enter lymph nodes from peripheral tissues...
  86. pmc The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping
    Susan L Troyan
    Breast Care Center, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Surg Oncol 16:2943-52. 2009
    ..The FLARE imaging system overcomes this major obstacle...
  87. doi Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes
    Samuele Calabro
    Novartis Vaccines and Diagnostics, Siena, Italy
    Vaccine 29:1812-23. 2011
    ..we show that all recruited cell types take up both adjuvant and antigen to transport them to the draining lymph nodes (LNs)...
  88. doi CCR7 is involved in the migration of neutrophils to lymph nodes
    Celine Beauvillain
    INSERM Unité 892, Centre de Recherche en Cancérologie Nantes Angers, 4 rue Larrey, Angers, France
    Blood 117:1196-204. 2011
    ..that neutrophils may participate in the regulation of adaptive immune responses, and can reach draining lymph nodes and cross-prime naive T cells...
  89. pmc Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase
    Laure Campillo-Gimenez
    INSERM U841, Faculté Créteil Henri Mondor, 8 rue du General Sarrail, 94010 Creteil, France
    J Virol 84:1838-46. 2010
    ..nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 ..
  90. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
    ..We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses...
  91. pmc Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans
    Alexander Link
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Am J Pathol 178:1662-75. 2011
    ..Similar to lymph nodes, TRCs were present throughout T-cell-rich areas and had dendritic cells associated with them...
  92. ncbi Economic analysis of targeting chemotherapy using a 21-gene RT-PCR assay in lymph-node-negative, estrogen-receptor-positive, early-stage breast cancer
    John Hornberger
    The SPHERE Institute Acumen, LLC, Burlingame, CA 94010, USA
    Am J Manag Care 11:313-24. 2005
    ....
  93. doi Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes
    Alexandre Boissonnas
    Institut National de la Santé et de la Recherche Médicale U932, Immunité et Cancer, Institut Curie, F 75245 Paris Cedex 05, France
    Immunity 32:266-78. 2010
    ..In tumor-draining lymph nodes, Foxp3(+) T cell neutralization induced a marked arrest in the migration of OTI T cells, increased numbers of ..
  94. pmc CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    Sandrine Henri
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 207:189-206. 2010
    ..that the dermis contains five distinct DC subsets and identified their migratory counterparts in draining lymph nodes. Based on this refined classification, we demonstrated that the quantitatively minor CD207+ CD103+ DDC subset ..
  95. pmc High prevalence of human cytomegalovirus proteins and nucleic acids in primary breast cancer and metastatic sentinel lymph nodes
    Chato Taher
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 8:e56795. 2013
    ..Increasing evidence implies that human cytomegalovirus (HCMV) infection is associated with several malignancies. We aimed to examine whether HCMV is present in breast cancer and sentinel lymph node (SLN) metastases...
  96. ncbi Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    Udaya K Liyanage
    Alvin J Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:2756-61. 2002
    ..These T(reg) may mitigate the immune response against cancer, and may partly explain the poor immune response against tumor Ags...
  97. pmc Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections
    Jason M Brenchley
    Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
    Blood 120:4172-81. 2012
    ..These data provide insights into how natural hosts are able to maintain high levels of plasma viremia while avoiding development of immunodeficiency...
  98. doi Combined ultrasmall superparamagnetic particles of iron oxide-enhanced and diffusion-weighted magnetic resonance imaging facilitates detection of metastases in normal-sized pelvic lymph nodes of patients with bladder and prostate cancer
    Frédéric D Birkhäuser
    University Hospital of Bern, Department of Urology, Bern, Switzerland
    Eur Urol 64:953-60. 2013
    ..Conventional cross-sectional imaging with computed tomography and magnetic resonance imaging (MRI) has limited accuracy for lymph node (LN) staging in bladder and prostate cancer patients...
  99. doi The humoral immune system has a key prognostic impact in node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:5405-13. 2008
    ..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
  100. pmc The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    Nicolas Fazilleau
    Department of Immunology and Microbial Sciences, La Jolla, California, USA
    Nat Immunol 10:375-84. 2009
    ..Our studies demonstrate a central function for differences in the binding strength of the T cell antigen receptor in the antigen-specific mechanisms that 'program' specialized effector T(FH) function in vivo...
  101. doi Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients
    Pauline Verdijk
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 15:2531-40. 2009
    ..The success of immunotherapy with dendritic cells (DC) to treat cancer is dependent on effective migration to the lymph nodes and subsequent activation of antigen-specific T cells...

Research Grants76

  1. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..memory B cells will be evaluated and quantified in different tissues including peripheral blood, intestines, lymph nodes, BM, and BAL samples of intravenously and mucosally inoculated macaques...
  2. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..e., the graft site) and migration of MSC to lymph nodes draining the graft site...
  3. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..Cells without CCR7 failed to traffic normally to recipient lymph nodes, and demonstrated a reduced capacity to expand within the spleen...
  4. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..cancer types express CXCR4 and metastasize to tissues that secrete SDF1, including bone marrow, lung, liver and lymph nodes. Treatment with CXCR4-neutralizing antibodies reduces metastatic tumor formation in a mouse model for human ..
  5. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..a role in induction of Th1 immunity against influenza and HSV-1 and are recruited in mouse infection models to lymph nodes to stimulate antiviral cytotoxic T-cells...
  6. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..directly infected with HIV- 1, or become infected after interaction with infected APC, then migrate to adjacent lymph nodes, leading to the transmission of HIV-1 from mucosal sites to the periphery...
  7. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..Selected genes will be tested for their expression in arthritic joints and joint-draining lymph nodes, sequenced, and their in vivo (arthritis-affecting) function will be tested in either knockout or IVSC mice, ..
  8. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..of myeloid cells around Mtb-infected alveolar macrophages (AMF) and slow to deliver bacilli to the thoracic lymph nodes (TLN) where immunity is primed...
  9. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..homeostasis of tissue resident lymphocytes by determining 1) T and B cell subset distribution in bone marrow, lymph nodes, bronchoalveolar lavage, and gut biopsies;and 2) the cytokine milieu of these tissues...
  10. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..These exogenously administered lung SP cells were found in the lung associated lymph nodes and parenchyma...
  11. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lymphatic vascular cell traffic from the periphery to lymph nodes occurs during both inflammatory responses as well as neoplasia...
  12. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..of pStat3, IL-6 and NF-kB and leukocyte infiltration in archived breast cancer samples with matched lymph nodes and distant metastasis...
  13. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..YYAA and SKG mouse TCR repertoires of the infiltrating T cells in the joints and peripheral T cells from lymph nodes. Retroviral infection of a TCR1 library generated from purified infiltrating T cells in the inflamed joints ..
  14. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lymph nodes are the initial sites of metastasis for most solid tumors, including breast carcinoma and melanoma...
  15. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..We hypothesize that ex vivo-generated MSCs home to the mesenteric lymph nodes (MLNs) and/or colonic lamina propria where they prevent/limit gut inflammation directly via their production of ..
  16. Lysosomal phospholipase A2 in autoimmune disease
    JAMES ALAN SHAYMAN; Fiscal Year: 2013
    ..The spleens and lymph nodes are characterized by the persistence of high levels of apoptotic bodies in association with resident ..
  17. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    ..This will include measures of BBB penetrance and tissue drug levels in brain, spleen, lymph nodes, and liver. Histologic and imaging assays will evaluate potential drug toxicities...
  18. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..in size (>100nm in diameter) and tend to stay at injection sites while smaller nanoparticles drain into lymph nodes with subcutaneous injections. They also have known toxicities post degradation...
  19. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
    ..spores are engulfed by alveolar macrophages where germinate to generate the bacteria, which spread through the lymph nodes to the bloodstream, eventually leading to systemic fatal shock presumably due to the action of the secreted ..
  20. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..Evidence suggests that cells infiltrating the lung early during infection transport antigen to the lymph nodes which contributes to the initiation of adaptive immunity...
  21. Novel Functions of S1P in Neuroinflammation
    TOMASZ K KORDULA; Fiscal Year: 2013
    ..MS symptoms, in part, by downregulating S1P1 on lymphocytes thus preventing their S1P-dependent egress from the lymph nodes. However, FTY720 also accumulates in the brain where it reduces astrogliosis;nevertheless, its effects in the ..
  22. Ligands and cofactors required for RORgt function in the immune system
    Dan Littman; Fiscal Year: 2013
    ..an appropriate T cell repertoire;it is essential for the differentiation of Lti cells that induce formation of lymph nodes and Peyer's patches in the fetus and of cryptopatches and isolated lymphoid follicles in the post-natal ..
  23. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..delivery system to improve tissue penetrance of ART into the reticuloendothelial system (RES;spleen, liver, lymph nodes) in mice...
  24. Regulatory targets and pathogenic mechanisms of anthrax edema factor
    Jin Mo Park; Fiscal Year: 2011
    ..anthracis-infected macrophages to lymph nodes and spreading of the bacterium to the blood circulation...
  25. Mechanisms of Sensitization in High Risk Corneal Grafts
    Reza Dana; Fiscal Year: 2013
    ..enhanced capacity of alloantigen-bearing antigen- presenting cells (APC) to gain access to regional lymph nodes;(ii) allosensitization is enhanced in the high- risk transplant setting due to graft bed microenvironment ..
  26. Effects of lymphangiogenesis stimulation on lung allograft rejection
    Souheil El-Chemaly; Fiscal Year: 2013
    ..g. by promoting antigen presentation within draining lymph nodes and stimulating alloimmune responses)...
  27. Role of IGF-IR tyrosine kinase in NPM-ALK-expressing T-cell lymphoma
    Hesham M Amin; Fiscal Year: 2013
    ..Patients typically present with advanced-stage disease and generalized involvement of the lymph nodes and other organs including skin, bone marrow, and liver...
  28. Analysis of NKLAM: A Novel Gene Associated With Cellular Cytotoxicity
    Jacki Kornbluth; Fiscal Year: 2013
    ..compared with WT after injection with B16 melanoma cells and show greater dissemination of lymphoma cells to lymph nodes from the primary tumor site. Finally, a critical finding is that NKLAM functions as an E3 ubiquitin ligase...
  29. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..Key findings late post-BMT include: 1. Small lymph nodes (LNs) and disorganized microarchitecture;2...
  30. The Role of PPAR Gamma in Fat-Resident Regulatory T Cells and Glucose Homeostasis
    SAGAR PRADEEP BAPAT; Fiscal Year: 2013
    ..showed that fTregs have a different gene expression signature compared to Tregs isolated from the spleen or lymph nodes in mice...
  31. Treatment of breast cancer tumor growth and metastasis with an anti-MMP-9 DNAzyme
    MIRANDA A HALLETT; Fiscal Year: 2011
    ..Breast cancer metastasizes to brain, lung, bone, liver and regional lymph nodes. Early detection and advancements in research have increased survival and enhanced quality of life...
  32. Immunomodulation in melanoma therapy
    NOAH A CRAFT; Fiscal Year: 2012
    ..leads to activation, maturation, and migration of dendritic cells (DCs) to the tumor site and to the draining lymph nodes. This DC activity leads to enhanced presentation of both vaccine and non-vaccine melanoma associated antigens ..
  33. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..and TNFSF11), a member of the TNF superfamily previously shown to have obligatory roles in the development of lymph nodes, the differentiation of medullary thymic epithelial cells, the differentiation of osteoclasts, and mammary ..
  34. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..In vivo, DC-SIGN- positive cells were demonstrated in lymph nodes, tonsils, skin, and the subepithelial region of the cervix...
  35. Antifibrotic Therapy to Improve Immune reconstitution in HIV
    Timothy W Schacker; Fiscal Year: 2013
    ..We will test a novel strategy to restore normal anatomy to lymph nodes that might allow more normal sized populations of CD4+ T cells to reconstitute...
  36. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas M Moran; Fiscal Year: 2010
    ..Our data suggests that the bone marrow derived monocytes migrate to the draining lymph nodes and participate in both innate and adaptive immunity...
  37. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..All women undergoing breast cancer treatment are at lifetime risk for LE. While removal of lymph nodes, surgery, and radiation are the major causal factors for LE, cancer treatment is necessary for life-saving...
  38. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
    Lymphocytes home from the blood into lymph nodes during the process of lymphocyte recirculation. Homing is initiated by the rolling of lymphocytes on high endothelial venules (HEVs) within the lymph node...
  39. The role of VEGF-C in resisting stress in prostate cancer
    Kaustubh Datta; Fiscal Year: 2013
    ..hundred patients with locally invasive prostate cancer and prostate cancer with metastases in the regional lymph nodes. The role of downstream targets of VEGF-C (e.g...
  40. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..of New Zealand White rabbits to the isolate resulted in severe eye disease and necrosis of the spleen and lymph nodes. In addition, viral DNA was identified in a variety of tissues by PCR during the acute infection (within 5 days ..
  41. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..We found that these T cells underwent massive expansion in the spleen and lymph nodes following intragastric infection, uniformly differentiated into [unreadable]multifunctional[unreadable] IFN-&..
  42. Effector and Memory Anti-Malaria CD8+ Cell Responses
    FIDEL P ZAVALA; Fiscal Year: 2013
    ..are delivered by mosquito bites, the T cell response is induced by dendritic cells (DCs) in skin draining lymph nodes (LN). Primed cells migrate to peripheral organs including the liver, where they develop memory CD8+ populations...
  43. Tissue compartmentalization of human lymphocytes
    Donna L Farber; Fiscal Year: 2013
    ..cells from blood and eight different tissues including lymphoid tissues (spleen, peripheral and tissue-draining lymph nodes), and mucosal tissues (lung, small and large intestines) from over 24 research-consented, previously healthy ..
  44. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2013
    ..They will assess the extent to which migration of virus-specific B cells/plasma cells from regional lymph nodes is required for the establishment of lung tissue plasma cell pools, and using genetic screening and a custom ..
  45. A Novel Oral Combination Pediatric HIV and TB Vaccine
    Michelle H Larsen; Fiscal Year: 2012
    ..the rapid induction of antiviral immunity in local tissues of the oral and intestinal mucosa and their draining lymph nodes. We hypothesize that live attenuated immunogens are optimal candidates because (i) they can induce innate and ..
  46. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..lineage, we found that infiltration of inflammatory macrophages into the Peyer's patches and mesenteric lymph nodes is impaired in the absence of FAK, and that this surprisingly correlates with reduced bacterial colonization of ..
  47. Prognosis and Effectiveness of Advanced Lung Cancer Treatment in the Elderly
    Juan P Wisnivesky; Fiscal Year: 2010
    ..The specific aims of the study are to: 1) evaluate the relationship between the number of positive lymph nodes and survival of NSCLC patients with N1 disease after adjustment for other prognostic factors;2) assess the ..
  48. Functional impact of dendritic cell phenotype in a mouse model of myositis
    Dana P Ascherman; Fiscal Year: 2010
    ..and intracellular cytokine staining of antigen-challenged lymphocytes derived from spleen and organ-draining lymph nodes of DC-immunized mice will further link the observed tissue phenotype to Th17 and/or Th1-polarized, Jo-1-..
  49. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2013
    ..ROCK2, and ROCK1/2 mice) the time course and locus of ROCK expression and activity in the lungs and thoracic lymph nodes following OVA sensitization and challenge...
  50. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..in proliferation, activation, and effector function of NK cells will be determined in the TG and cervical lymph nodes. Additionally, chemokines (CCL3/MIP-11, CCL4/MIP-12, CXCL9/MIG, CXCL10/IP-10, CXCL12/SDF, and CCL5/RANTES) ..
  51. Lymph Node Alterations in Cancer
    M ALANNA RUDDELL; Fiscal Year: 2013
    ..in many human cancers, including melanoma, colon, breast, and head and neck cancers, suggesting that the lymph nodes are somehow involved in metastasis...
  52. Optimized Adaptation of Simian-tropic R5 HIV Clade C to Pig-tailed Macaques
    RUTH MARGRIT RUPRECHT; Fiscal Year: 2013
    ..We will also compare viral evolution in different compartments (PBMC, lymph nodes, and brain)...
  53. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
    ..1,25(OH)2D3 on the production of IL-17 and other cytokines (brains and spinal cords as well as splenocytes and lymph nodes will be isolated from EAE mice and the effect of 1,25(OH)2D3 on the production of various cytokines including ..
  54. HS1 Function in Dendritic Cells
    Janis K Burkhardt; Fiscal Year: 2011
    ..by collecting pathogens and tumor cell debris in peripheral tissues, and delivering these as peptides to lymph nodes for presentation to T cells...
  55. The Regulation of Inflammatory Responses by CD73
    Linda F Thompson; Fiscal Year: 2012
    ..Cd73-/- mice also show increased lymphocyte migration across high endothelial venules (HEV) of draining lymph nodes. This is also due to lack of A2BAR signaling in non-hematopoietic cells...
  56. Fluorescein for Sentinel Lymph Node Detection
    James M McGreevy; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The use of fluorescent drugs for the location and direct visualization of lymph nodes in Sentinel Lymph Node (SLN) biopsy procedures in the operating room can replace non-fluorescent and ..
  57. Real-time Measurement of Self-antigen Recognition by Lymphocytes In Vivo
    ALEX YEE CHEN HUANG; Fiscal Year: 2012
    ..high-resolution data addressing the impact of self-ligand surveillance by circulating mature lymphocytes in the lymph nodes. We also plan to undertake a series of studies aimed to delineate the relative contribution of various self-..
  58. Obesity, Inflammation, and Lung Injury After Lung Transplantation
    David J Lederer; Fiscal Year: 2013
    ..quantitative CT imaging, (2) immunophenotyping of macrophages and T cells from intrathoracic adipose tissue and lymph nodes obtained immediately before and after lung transplantation, and (3) measurement of adipokines and cytokines in ..
  59. Toll-like receptor mediated regulation of effector and memory CD4 T cell response
    Chandrashekhar Pasare; Fiscal Year: 2013
    ..that involves enhanced expression of MHC and co-stimulatory molecules as well as migration to the draining lymph nodes to prime naive T cells...
  60. Mast cell actions in chronic progressive versus relapsing remitting EAE
    JULIANNE K HATFIELD; Fiscal Year: 2013
    ..evidence that mast cells affect T cell reactivation in CNS-proximal sites such as the meninges and cervical lymph nodes. We have developed a mast cell deficient mouse on the SJL background that shows mast cell dependent severity of ..
  61. Specific Contribution of a New IG Isotype (IGT) in Teleost Fish Immune Responses
    J Oriol Sunyer; Fiscal Year: 2013
    ..Since fish lack peyer patches and lymph nodes in the gut, a lower spatial and functional complexity of the local mucosal responses should be expected, ..
  62. A Novel Therapy for Radiation-Induced Xerostomia Using Human Salivary Stem Cells
    QUYNH THU XUAN LE; Fiscal Year: 2012
    ..crucial for resting salivary function throughout the day, because of their locations adjacent to the draining lymph nodes. For this reason, there is strong interest in rescuing SMG function...
  63. Ocular Lymphangiogenesis
    DANIEL J CARR; Fiscal Year: 2010
    ..of infection, an adaptive immune response ensues through the "education" of effector cells within the draining lymph nodes. In response to virus infection of the cornea, a strong angiogenic response has been noted with new blood ..
  64. A gene therapy for bacterial translocation in mice with whole body irradiation
    Fujio Suzuki; Fiscal Year: 2010
    ..burned mice, IL-10(-) IL-12(+) macrophages (M1 macrophages) distributed in lamina propria (LP) and mesenteric lymph nodes (MLN) have been identified as major effector cells in host antibacterial innate immunities against enterococcal ..
  65. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..lymphotoxin-beta receptor (LTbR)-Ig do not develop Peyer's patches ; however, these mice exhibit mesenteric lymph nodes which drain the small intestine...
  66. Alphavirus Replicons for Mucosal HIV Vaccines
    Michael Vajdy; Fiscal Year: 2002
    ..there is evidence for presence of SIV-specific CTL activity in the vaginal mucosa as well as in the draining lymph nodes of rhesus macaques inoculated intra-vaginally with SIV...
  67. XENOGENEIC MODEL FOR HOMING OF HUMAN LYMPHOCYTES
    Sharon Evans; Fiscal Year: 1993
    ..Lymphocyte migration into peripheral lymph nodes is initiated by the interaction of the L-selectin homing receptor on lymphocytes with the vascular addressin on ..
  68. SURGERY AND IV NUTRITION MODULATE MACROPHAGE FUNCTION
    W Helton; Fiscal Year: 1999
    ..Mphis will be isolated from the mesenteric lymph nodes, peritoneal cavity, lung, and spleen and their function studied...
  69. Maternal transfer of protection from allergic gastrointestinal disease
    Lynn Puddington; Fiscal Year: 2009
    ..dose of antigen delivered from mother to child in breast milk induces antigen-specific Tregs in gut-draining lymph nodes. Perhaps the acquisition of antigen from breast milk provides the perfect context (i.e...
  70. Fluorescence Imaging for Sentinel Lymph Node Mapping
    Eva Sevick Muraca; Fiscal Year: 2003
    ..The radiopharmaceutical and the blue dye then convect to the sentinel lymph nodes. Prior to surgery, the sentinel node is localized via a gamma camera and in surgery, is identified with a hand-..
  71. LCDIO FOR LYMPH NODE MR IMAGING
    Ralph Weissleder; Fiscal Year: 2001
    ..based iron oxide (LCDIO) contrast agents for the assessment of active tumor growth in local and regional lymph nodes during cancer spread...
  72. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2009
    Lymphocytes "home" from the blood into lymph nodes as part of the process of lymphocyte recirculation. This homing process has multiple steps consisting of a sequence of adhesive and signaling interactions...
  73. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2002
    ..The presence of metastatic disease in the mediastinal lymph nodes of NSCLC patients has profound prognostic and therapeutic implications...
  74. Coexpression of EGFRvlll/ErbB2 in Human Breast Cancer
    Careen Tang; Fiscal Year: 2005
    ..Even more striking was that 100 percent (4/4) of ErbB-2 positive metastatic lymph nodes co-overexpressed EGFRvIII...
  75. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..The presence of metastatic disease in the mediastinal lymph nodes of NSCLC patients has profound prognostic and therapeutic implications...
  76. TRANSLOCATING BACTERIA: ROLE IN POSTSURGICAL SEPSIS
    Carol Wells; Fiscal Year: 1990
    ..In several animal models, translocating bacteria can be most reliably detected in mesenteric lymph nodes, and translocation is increased either after a shift in the intestinal flora or after immunosuppressive insults ..