sebaceous glands

Summary

Summary: Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.

Top Publications

  1. pmc Hedgehog signaling regulates sebaceous gland development
    Mary Allen
    Department of Dermatology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 0932, USA
    Am J Pathol 163:2173-8. 2003
  2. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
  3. ncbi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
  4. pmc TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis
    Monika Petersson
    Center for Molecular Medicine Cologne CMMC, Institute of Pathology, University of Cologne, Cologne, Germany
    EMBO J 30:3004-18. 2011
  5. pmc Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells
    Amanda M Nelson
    Jake Gittlen Cancer Research Foundation
    J Clin Invest 118:1468-78. 2008
  6. ncbi Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?
    K R Smith
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Lipid Res 49:271-81. 2008
  7. pmc Scratching the surface of skin development
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
    Nature 445:834-42. 2007
  8. ncbi Essential role for Sonic hedgehog during hair follicle morphogenesis
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 205:1-9. 1999
  9. pmc Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin
    S Ghazizadeh
    Department of Oral Biology and Pathology, SUNY at Stony Brook, Stony Brook, NY 11794 8702, USA
    EMBO J 20:1215-22. 2001
  10. ncbi Blimp-1: a marker of terminal differentiation but not of sebocytic progenitor cells
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 37:362-70. 2010

Research Grants

Detail Information

Publications239 found, 100 shown here

  1. pmc Hedgehog signaling regulates sebaceous gland development
    Mary Allen
    Department of Dermatology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 0932, USA
    Am J Pathol 163:2173-8. 2003
    ..sebocyte development, Hedgehog pathway activation led to a striking increase both in size and number of sebaceous glands. Remarkably, ectopic Hedgehog signaling also triggered the formation of sebaceous glands from footpad ..
  2. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
    ....
  3. ncbi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
    ..Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell...
  4. pmc TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis
    Monika Petersson
    Center for Molecular Medicine Cologne CMMC, Institute of Pathology, University of Cologne, Cologne, Germany
    EMBO J 30:3004-18. 2011
    Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs)...
  5. pmc Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells
    Amanda M Nelson
    Jake Gittlen Cancer Research Foundation
    J Clin Invest 118:1468-78. 2008
    ..It is known that the drug induces apoptosis in cells cultured from human sebaceous glands, but its mechanism of action has not been determined...
  6. ncbi Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?
    K R Smith
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Lipid Res 49:271-81. 2008
    b>Sebaceous glands are intriguing glands that are found throughout the human body except on the palms of the hands and soles of the feet...
  7. pmc Scratching the surface of skin development
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
    Nature 445:834-42. 2007
    ..to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for ..
  8. ncbi Essential role for Sonic hedgehog during hair follicle morphogenesis
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 205:1-9. 1999
    ..Our findings reveal an essential role for Shh during hair follicle morphogenesis, where it is required for normal advancement beyond the hair germ stage of development...
  9. pmc Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin
    S Ghazizadeh
    Department of Oral Biology and Pathology, SUNY at Stony Brook, Stony Brook, NY 11794 8702, USA
    EMBO J 20:1215-22. 2001
    ..In most instances, labeled cells were confined to one or more follicular compartments or solely to sebaceous glands. Labeled keratinocytes in interfollicular epidermis were confined to distinct columnar units representing ..
  10. ncbi Blimp-1: a marker of terminal differentiation but not of sebocytic progenitor cells
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 37:362-70. 2010
    ....
  11. ncbi Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
    ..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland...
  12. pmc Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
    Hubert C Chen
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 109:175-81. 2002
    ..Here we report the effects of DGAT1 deficiency on fur and sebaceous glands. Adult Dgat(-/-) mice had dry fur and hair loss, which were associated with atrophic sebaceous glands and fur ..
  13. ncbi TNF-α increases lipogenesis via JNK and PI3K/Akt pathways in SZ95 human sebocytes
    Jeong June Choi
    Laboratory of Pathology, College of Oriental Medicine, Daejeon University, Daejeon 300 716, Republic of Korea
    J Dermatol Sci 65:179-88. 2012
    ..Tumor necrosis factor-alpha (TNF-α) is an important pathophysiologic factor involved in the development of acne. However, its role is unclear...
  14. ncbi Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation
    D Deplewski
    The University of Chicago, Pritzker School of Medicine, Department of Medicine, Illinois 60637 1470, USA
    Endocrinology 140:4089-94. 1999
    ..These data are consistent with the concept that increases in GH and IGF production contribute in complementary ways to the increase in sebum production during puberty and in acromegaly...
  15. ncbi Modelling the remission of individual acne lesions in vitro
    M M T Downie
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital Box 232, Hills Road, Cambridge CB2 2QR, U K
    Br J Dermatol 147:869-78. 2002
    ..We have previously described the cytokines that will promote in vitro the lesions of acne...
  16. ncbi Development and homeostasis of the sebaceous gland
    Catherin Niemann
    Center for Molecular Medicine Cologne, University of Cologne, Germany
    Semin Cell Dev Biol 23:928-36. 2012
    ..normal development and maintenance of the sebaceous gland are required for skin homeostasis since atrophic sebaceous glands and disturbances in sebaceous lipid composition result in major defects of the physiological barrier and ..
  17. ncbi Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Invest Dermatol 113:1011-20. 1999
    ..Thus SZ95 is an immortalized human sebaceous gland cell line that shows the morphologic, phenotypic and functional characteristics of normal human sebocytes...
  18. pmc Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes
    Dong Youn Lee
    J Invest Dermatol 128:1863-6. 2008
  19. ncbi Metabolic fate and selective utilization of major fatty acids in human sebaceous gland
    Apostolos Pappas
    Skin Biology TRC, Johnson and Johnson Consumer Companies Worldwide, Skillman, New Jersey, USA
    J Invest Dermatol 118:164-71. 2002
    ..polyunsaturated (18:2, Delta9,12) fatty acids was followed in biopsy punches from human facial skin rich in sebaceous glands. Acetate was incorporated into all of the cellular and secreted lipids and 16:0 was incorporated into all of ..
  20. ncbi Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
    Julia Reichelt
    Institut fur Physiologische Chemie, Universitat Bonn, Bonn, Germany
    Eur J Cell Biol 83:747-59. 2004
    ....
  21. ncbi Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands
    K Krause
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:166-70. 2007
    ..However, further investigations into the downstream effects of CRH and Uct are required to elucidate the mechanism by which these neuropeptides could establish a stress-related pathophysiological condition in the skin...
  22. ncbi Selective cultivation of normal human sebocytes in vitro; a simple modified technique for a better cell yield
    M Badawy Abdel-Naser
    Department of Dermatology and Venereology, Ain Shams University Hospital, Cairo, Egypt
    Exp Dermatol 13:562-6. 2004
    ..To conclude, covering the sebaceous glands during the first 72 h of primary culture provides an excellent contact with the culture plate and hence a ..
  23. ncbi Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity
    Lan Ge
    The Skin Research Center of Johnson and Johnson, CPWW, Skillman, New Jersey, USA
    J Invest Dermatol 120:707-14. 2003
    ..This work identifies Delta-6 desaturase/FADS2 as the major fatty acid desaturase in human sebaceous glands and suggests that the environment of the sebaceous gland permits catalysis of the sebaceous-type reaction and ..
  24. ncbi Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin
    Cristina Lo Celso
    Massachusetts General Hospital, Center for Regenerative Medicine, Boston, Massachusetts, USA
    Stem Cells 26:1241-52. 2008
    ..Our studies provide evidence for a bipotential epidermal stem cell population in an in vitro model of human epidermal lineage selection and highlight the importance of Myc as a regulator of sebocyte differentiation...
  25. ncbi Sebaceous glands in acne patients express high levels of neutral endopeptidase
    M Toyoda
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Exp Dermatol 11:241-7. 2002
    ..of acne, we used immunohistochemistry to compare the distribution of SP-containing nerve fibers around sebaceous glands and the expression of neutral endopeptidase in sebaceous acini of the facial skin of acne patients and of ..
  26. ncbi The human sebocyte culture model provides new insights into development and management of seborrhoea and acne
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Dermatology 196:21-31. 1998
    ..Androgens affected sebocyte activity in vitro in a manner dependent on the localization of the sebaceous glands. In vitro stimulation of sebocyte proliferation by androgens could be completely abolished by spironolactone...
  27. ncbi Role of testosterone in stimulating seasonal changes in a potential avian chemosignal
    Danielle J Whittaker
    BEACON Center for the Study of Evolution in Action, Michigan State University, 1441 Biomedical and Physical Sciences Building, East Lansing, MI 48824, USA
    J Chem Ecol 37:1349-57. 2011
    ..Our results suggest that testosterone levels likely interact with other seasonally induced physiological changes to affect volatile compound amounts in preen oil...
  28. ncbi Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne
    W Chen
    Department of Dermatology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan
    J Eur Acad Dermatol Venereol 20:846-52. 2006
    ..Factors regulating cutaneous steroidogenesis associated with disease status remain largely unknown...
  29. ncbi Insights from the asebia mouse: a molecular sebaceous gland defect leading to cicatricial alopecia
    K S Stenn
    Juvenir Biosciences, Inc, Inc, Skillman, New Jersey 08558 9418, USA
    J Cutan Pathol 28:445-7. 2001
    ..In this paper the relevance of this mutant to human alopecias is discussed and the point emphasized that the pathogenesis of some forms of human cicatricial alopecia could involve the sebaceous gland...
  30. doi Abundant expression of neuronatin in normal eccrine, apocrine and sebaceous glands and their neoplasms
    Long Dugu
    J Dermatol 37:846-8. 2010
  31. ncbi Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes
    Wesley J Harrison
    Centre for Cutaneous Research, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    J Invest Dermatol 127:1309-17. 2007
    ....
  32. ncbi Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo
    C Rosignoli
    Galderma R and D, Sophia Antipolis Cedex, Valbonne, France INSERM U439 Pathologie Moléculaire des Récepteurs Nucléaires, Montpellier, France
    Exp Dermatol 12:480-9. 2003
    ..We demonstrated that the growth of sebaceous glands observed after androgen treatment was due to both an increase in sebocyte proliferation and a parallel ..
  33. ncbi "Sebocytes' makeup": novel mechanisms and concepts in the physiology of the human sebaceous glands
    Balazs I Toth
    Department of Physiology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Hungary
    Pflugers Arch 461:593-606. 2011
    ....
  34. ncbi Elevated levels of the endogenous retrovirus ERV3 in human sebaceous glands
    A C Andersson
    Department of Pathology, Uppsala University Hospital, Sweden
    J Invest Dermatol 106:125-8. 1996
    ..We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary...
  35. ncbi Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes
    Istvan Nagy
    Department of Dermatology and Allergology, University of Szeged, Koranyi fasor 6, 6720 Szeged, Hungary
    Microbes Infect 8:2195-205. 2006
    ..acnes vary in their capacity to stimulate an inflammatory response within the pilosebaceous follicle...
  36. ncbi Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells
    Violeta Silva-Vargas
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Dev Cell 9:121-31. 2005
    ..we show that short-term, low-level beta-catenin activation stimulates de novo hair follicle formation from sebaceous glands and interfollicular epidermis, while only sustained, high-level activation induces new follicles from ..
  37. pmc More than one way to skin . .
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 22:976-85. 2008
    ..Understanding how these stem cells maintain normal homeostasis and wound repair in the skin is particularly important, as these mechanisms, when defective, lead to skin tissue diseases including cancers...
  38. ncbi Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro
    Katsuhiro Iinuma
    Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    J Invest Dermatol 129:2113-9. 2009
    ..acnes directly influences lipogenesis in sebaceous glands. In this study, we showed that a culture medium of P. acnes (acnes-CM) and formalin-killed P...
  39. ncbi The contribution of the arrector pili muscle and sebaceous glands to the follicular unit structure
    Enrique Poblet
    Department of Pathology, Hospital General Universitario de Albacete, Universidad Las Palmas Gran Canaria, Spain
    J Am Acad Dermatol 51:217-22. 2004
    ..The sebaceous glands and the arrector pili muscle, as part of the pilosebaceous unit, should be viewed as important parts of this ..
  40. pmc C/EBPalpha and C/EBPbeta are required for Sebocyte differentiation and stratified squamous differentiation in adult mouse skin
    John S House
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 5:e9837. 2010
    ..and C/EBPbeta are bZIP transcription factors that are highly expressed in the interfollicular epidermis and sebaceous glands of skin and yet germ line deletion of either family member alone has only mild or no effect on keratinocyte ..
  41. ncbi Designer skin: lineage commitment in postnatal epidermis
    Catherin Niemann
    Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Trends Cell Biol 12:185-92. 2002
    ..cells that produce daughters that differentiate to form the interfollicular epidermis, hair follicles and sebaceous glands. Diffusible factors, cell-cell contact and extracellular matrix proteins are all important components of the ..
  42. ncbi Sebaceous glands and the prostaglandin pathway--key stones of an exciting mosaic
    Christos C Zouboulis
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 125:x-xi. 2005
  43. ncbi Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 120:905-14. 2003
    ..antibodies to the above proteins localized to epidermis, hair follicles, sebaceous ducts, and sebaceous glands in sections of facial skin. Results of immunohistochemistry were confirmed with Western blotting...
  44. ncbi Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    M Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, 53706, USA
    J Nutr 131:2260-8. 2001
    ..These results reveal a physiologic role of SCD in cholesterol homeostasis as well as in the de novo biosynthesis of cholesterol esters, triglycerides and wax esters required for normal skin and eyelid function...
  45. ncbi Thematic review series: skin lipids. Antimicrobial lipids at the skin surface
    David R Drake
    Dows Institute, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 49:4-11. 2008
    ..and are carried to the surface as cells differentiate, whereas others are secreted onto the surface from the sebaceous glands. One such group, free sphingoid bases, are known to have broad antimicrobial activity, and our previous ..
  46. ncbi Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin
    Y Zheng
    Johnson and Johnson Skin Biology TRC, Grandview Road, Skillman, New Jersey 08558, USA
    Genomics 71:182-91. 2001
    ..Scd3 expression changes during the mouse hair cycle but not as dramatically as Scd1. The tissue-specific and sex-dependent expression of Scd3 suggests the presence of gene- and hormonal-specific control mechanisms...
  47. pmc Hedgehog signaling, keratin 6 induction, and sebaceous gland morphogenesis: implications for pachyonychia congenita and related conditions
    Li Hong Gu
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Pathol 173:752-61. 2008
    ..expressed Gli2, a Hedgehog (Hh) signal effector, to show that K6a expression correlates with duct fate in sebaceous glands (SGs)...
  48. ncbi Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse
    Y Zheng
    Nat Genet 23:268-70. 1999
  49. ncbi The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells
    D Thiboutot
    Section of Dermatology, Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 115:614-9. 2000
    ..Lipid metabolism in sebaceous glands and preputial glands of rodents is regulated by alpha-melanocyte stimulating hormone, the major agonist for ..
  50. ncbi Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands
    Theodosios Alestas
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    J Mol Med (Berl) 84:75-87. 2006
    ..signalling pathways, of interleukins 6 and 8 and of peroxisome proliferator-activated receptors in sebaceous glands of acne-involved facial skin was compared with those of non-involved skin of acne patients and of healthy ..
  51. ncbi Role for ELOVL3 and fatty acid chain length in development of hair and skin function
    Rolf Westerberg
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 279:5621-9. 2004
    ..of very long chain fatty acids, revealed a distinct expression in the skin that was restricted to the sebaceous glands and the epithelial cells of the hair follicles...
  52. ncbi Smad7-induced beta-catenin degradation alters epidermal appendage development
    Gangwen Han
    Department of Otolaryngology, Oregon Health and Science University, Portland, 97239, USA
    Dev Cell 11:301-12. 2006
    ..Coexpression of the Smurf2 and Smad7 transgenes exacerbated Smad7-induced abnormalities in hair follicles and sebaceous glands. Conversely, when endogenous Smad7 was knocked down, keratinocytes exhibited increased beta-catenin protein ..
  53. ncbi Effects of topically applied antiandrogenic compounds on sebaceous glands of hamster ears and flank organs
    H G Schröder
    Research Laboratories of Schering AG, West Berlin, Federal Republic of Germany
    J Invest Dermatol 92:769-73. 1989
    Growth of sebaceous glands in the ears and flank organs of castrated male hamsters is dependent on androgen substitution...
  54. ncbi Gender differences and effects of sex steroids and dehydroepiandrosterone on androgen and oestrogen alpha receptors in mouse sebaceous glands
    L Azzi
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec G1V 4G2, Canada
    Br J Dermatol 154:21-7. 2006
    ..It is generally believed that the sebaceous gland is an intracrine organ which synthesizes its own active hormones to meet its local needs...
  55. ncbi Neuropeptides and sebaceous glands
    Masahiko Toyoda
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyoma 930 0194, Japan
    Eur J Dermatol 12:422-7. 2002
    ..We show morphological alterations of sebaceous glands elicited by SP and differences in expression of various neurogenic factors in association with sebaceous ..
  56. ncbi Sexual hormones in human skin
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Horm Metab Res 39:85-95. 2007
    ..upon the expression of each of the androgen- and estrogen-synthesizing enzymes in each cell type, with sebaceous glands and sweat glands being the major contributors...
  57. pmc Why do we have apocrine and sebaceous glands?
    A M Porter
    Redcrest, Health Rise, Camberley, Surrey GU15 2ER, UK
    J R Soc Med 94:236-7. 2001
    ..In colder conditions sebum changes its nature and repels rain from skin and hair...
  58. pmc A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus
    Uffe Birk Jensen
    Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
    J Cell Sci 121:609-17. 2008
    ..These cells are non-quiescent and possess a unique transcript profile compared with bulge stem cells and may represent a distinct reservoir of epidermal stem or progenitor cells...
  59. ncbi Regulation of human sebaceous glands
    Diane Thiboutot
    The Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA, USA
    J Invest Dermatol 123:1-12. 2004
  60. ncbi Androgen metabolism in sebaceous glands from subjects with and without acne
    D Thiboutot
    Section of Dermatology, Division of Internal Medicine, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Arch Dermatol 135:1041-5. 1999
    ..in the activity of 17beta-hydroxysteroid dehydrogenase and 5alpha-reductase (responsible for the production of testosterone and dihydrotestosterone, respectively) in sebaceous glands obtained from men and women with and without acne.
  61. ncbi 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes
    Amanda M Nelson
    The Jake Gittlen Cancer Research Foundation, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
    J Invest Dermatol 126:2178-89. 2006
    ..Taken together these data indicate that 13-cis RA causes cell cycle arrest and induces apoptosis in SEB-1 sebocytes by a RAR-independent mechanism, which contributes to its sebosuppressive effect and the resolution of acne...
  62. ncbi Multiple tiny ectopic sebaceous glands discovered throughout entire esophageal tract
    Wei Peng Wang
    Division of Gastroenterology, Department of Internal Medicine, Madou Branch, Sinlau Hospital, 20 Lingtzulin, Madou Town, Tainan County 72152, Taiwan
    Dig Dis Sci 54:2754-7. 2009
    ..The patient's blood and serum findings were unremarkable. Our final diagnosis was multiple tiny ectopic sebaceous glands in the esophagus...
  63. doi Illuminating role of CYP1A1 in skin function
    Jo M Rowe
    J Invest Dermatol 128:1866-8. 2008
  64. ncbi Selective photothermolysis of the sebaceous glands for acne treatment
    Jenifer R Lloyd
    Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272, USA
    Lasers Surg Med 31:115-20. 2002
    The purpose of this study is to evaluate the efficacy of a long pulse diode laser (Cynosure, Inc.) to target and destroy enlarged sebaceous glands that are preloaded with Indocyanine green (ICG) chromophore.
  65. ncbi Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles
    Chang Yi Cui
    Laboratory of Genetics, National Institutes of Health National Institute on Aging, Baltimore, MD 21224, USA
    Hum Mol Genet 12:2931-40. 2003
    ..Marked hyperplasia resulted from expansion of the sebocyte-producing zone in sebaceous glands, with particularly high expression of the transgene and the replication marker PCNA, and correspondingly high ..
  66. ncbi Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice
    Joachim W Fluhr
    Dermatology Services, Veterans Administration Medical Center, and Department of Dermatology University of California, San Francisco, California, USA
    J Invest Dermatol 120:728-37. 2003
    The only known function of human sebaceous glands is the provocation of acne...
  67. ncbi Ectopic sebaceous glands
    Akiko Harada
    Matsushita Health Care Center, Moriguchi, Japan
    Gastrointest Endosc 60:97. 2004
  68. ncbi [Sebaceous glands as transporters of vitamin E]
    S Ekanayake-Mudiyanselage
    Northwestern University, Chicago, USA
    Hautarzt 57:291-6. 2006
    Human sebum is produced by sebaceous glands and reaches the skin surface via secretion through the hair shaft...
  69. doi Education and imaging. Gastrointestinal: ectopic sebaceous glands in the esophagus
    I F Wei
    Division of Gastroenterology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 23:338. 2008
  70. ncbi Propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 129:2093-6. 2009
    ..acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that P. acnes-induced lipids may represent a recruitment of allies and/or enemies of the human skin...
  71. ncbi Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production
    Chikakazu Iwata
    Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    J Invest Dermatol 125:865-72. 2005
    ..Similarly, topical administration of indomethacin to hamster auricles caused the development of sebaceous glands with the augmentation of sebum deposition in vivo...
  72. ncbi [Histology of skin and hair follicle]
    Catherine Prost-Squarcioni
    Laboratoire d histologie EA3410, UFR Leonard de Vinci, Bobigny, France
    Med Sci (Paris) 22:131-7. 2006
    ..An attempt has been made in this paper to precisely give the location of molecules that are relevant in basic skin functions and understanding of auto-immune and genetic diseases...
  73. ncbi Expression of the high-affinity laminin receptor (67 kDa) in normal human skin and appendages
    S Cavalieri
    Department of Dermatology, Catholic University of the Sacred Heart, Rome, Italy
    Int J Immunopathol Pharmacol 18:223-31. 2005
    ..In sebaceous glands and in eccrine sweat glands the secreting epithelium was positive...
  74. ncbi Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone
    Lamia Azzi
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Quebec City, QC, Canada
    J Invest Dermatol 124:22-7. 2005
    ..GDX triggers a rapid hair growth from telogen to anagen with a thicker hair shaft diameter in females. This data shows that DHT, E2, and DHEA exert specific effects on the different skin layers and appendages...
  75. ncbi Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Heidelberg, Germany
    J Invest Dermatol 123:937-49. 2004
    ..Taken together, our data result in a complete molecular map of the extraneuronal cholinergic system of the skin that may be translated into distinct functional reaction patterns...
  76. ncbi gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 7:731-43. 2004
    ..b>Sebaceous glands also fail to form in gamma-secretase-deficient mice...
  77. ncbi Comedone formation: etiology, clinical presentation, and treatment
    William J Cunliffe
    Skin Research Centre, University of Leeds, Leeds, UK
    Clin Dermatol 22:367-74. 2004
    ..The glass slide is gently removed, taking with it the upper part of the stratum corneum and microcomedones, which are then analyzed by low-power microscopy or digital image analysis.(1-3)..
  78. ncbi Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation
    Alan D Proia
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Cutan Pathol 34:876-81. 2007
    ..Adnexal tumors with divergent lines of differentiation are uncommon. Herein, I report a hamartoma of the eyelid with follicular, sebaceous and apocrine differentiation that exhibited prominent melanin pigmentation...
  79. ncbi Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
    Sonja Ständer
    Department of Dermatology, University Hospital Munster, Germany
    J Dermatol Sci 38:177-88. 2005
    ..Cannabinoid receptors mediate the psychopharmacological action of marijuana and have been localized in the central and peripheral nervous system as well as on cells of the immune system...
  80. ncbi Efficient differentiation into skin cells of bone marrow cells recovered in a pellet after density gradient fractionation
    Reinhold J Medina
    Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Int J Mol Med 17:721-7. 2006
    ..These results indicate that density gradient fractionation results in significant loss of specific progenitor cells into the usually discarded pellet fraction...
  81. ncbi Age-associated decrease of CD1d protein production in normal human skin
    M A Adly
    Department of Zoology, Sohag Faculty of Science, South Valley University, Sohag, Egypt, and Department of Dermatology and Venereology, Faculty of Medicine, University Hospital of Hamburg Eppendorf, Germany
    Br J Dermatol 155:186-91. 2006
    ..CD1d belongs to a family of antigen-presenting molecules structurally related to the classical major histocompatibility complex class I proteins...
  82. ncbi Localization of human interleukin 13 receptor in non-haematopoietic cells
    M Akaiwa
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cytokine 13:75-84. 2001
    ..Fibroblasts and endothelial cells were stained in some tissues. These results provide clues to elucidate the known pathological roles of IL-13 in atopic dermatitis and allergic rhinitis, as well as its unknown physiological roles...
  83. pmc Wnt signaling induces epithelial differentiation during cutaneous wound healing
    Carrie Fathke
    Department of Surgery, University of Washington School of Medicine, Seattle, WA 98195, USA
    BMC Cell Biol 7:4. 2006
    ....
  84. ncbi Quantitative research on skin pore widening using a stereoimage optical topometer and Sebutape
    Ho Youn Jo
    Department of Dermatology, College of Medicine, Kangwon National University, Kangwon, Korea
    Skin Res Technol 13:162-8. 2007
    ..In this study, bioengineering methods were applied to evaluate skin pore widening. The results from bioengineering measurements were compared with clinical visual assessment...
  85. ncbi Differential expression of fatty acid transport proteins in epidermis and skin appendages
    Matthias Schmuth
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    J Invest Dermatol 125:1174-81. 2005
    ..adult skin, FATP1 and -3 are expressed predominantly by keratinocytes, whereas FATP4 is strongly expressed by sebaceous glands and FATP6 by hair follicle epithelia...
  86. pmc Expression of CD1d in human scalp skin and hair follicles: hair cycle related alterations
    M A Adly
    Department of Zoology, Sohag Faculty of Science, South Valley University, Sohage, 44106 Egypt
    J Clin Pathol 58:1278-82. 2005
    ..CD1d is expressed by cells of lymphoid and myeloid origin, and by cells outside of the lymphoid and myeloid lineages, such as human keratinocytes of psoriatic skin...
  87. ncbi [Percutaneous absorption]
    C Lafforgue
    Laboratoire dermopharmacologie et cosmétologie, Université Paris 11 Sud, Faculte de Pharmacie, 5, rue Jean Baptiste Clement, 92296 Chatenay Malabry Cedex
    Ann Dermatol Venereol 134:2S18-23. 2007
  88. pmc The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development
    Richard Grose
    Centre for Tumour Biology, Institute of Cancer, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    EMBO J 26:1268-78. 2007
    ..Thus we describe a novel role of Fgfr2b and provide the first evidence of a tyrosine kinase receptor playing a tumor suppressive role in the skin...
  89. ncbi Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit
    Louise E Russell
    Centre for Cutaneous Research and Centre for Endocrinology, Bart s and the London Queen Mary s School of Medicine and Dentistry, Queen Mary College, University of London, London, UK
    Exp Dermatol 16:844-52. 2007
    ..as within a range of primary and immortalized human cell lines derived from human skin, hair follicle and sebaceous glands. Furthermore, we have shown that synthetic LXR specific agonists GW683965 and TO901317 significantly inhibit ..
  90. ncbi Patterns of nestin expression in human skin
    Yun Wang
    Department of Cell Biology, The Third Military Medical University, Chong Qing 400038, PR China
    Cell Biol Int 30:144-8. 2006
    ..The level of nestin mRNA transcription was much higher in the bulge region of the follicle than in the sebaceous gland. These results show that the pattern of nestin expression is related to the differentiation of epidermal stem cells...
  91. ncbi Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone in alopecia areata
    Hei Sung Kim
    Department of Dermatology, St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Exp Dermatol 15:515-22. 2006
    ..01). The meaning of this enhanced expression and their role in the pathogenesis of AA should be further evaluated in future...
  92. ncbi Disulphide reaction staining for the identification of integumental elastic fibres
    W Meyer
    Anatomical Institute, University of Veterinary Medicine, Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany
    Arch Dermatol Res 297:177-9. 2005
    ..the elastic components of the connective tissue sheath of hair follicles, apocrine tubular glands, and sebaceous glands, and of the connective tissue surrounding the cutaneous muscle...
  93. ncbi Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions
    Sachiko Matsuhashi
    Division of Hepatology and Metabolism, Department of Internal Medicine, Saga Medical School, Saga University, Saga, Japan
    Exp Dermatol 16:179-84. 2007
    ..The cells of sebaceous glands and sweat glands also were PDCD4-positive...
  94. ncbi Peptidylarginine deiminase isoforms are differentially expressed in the anagen hair follicles and other human skin appendages
    Rachida Nachat
    CNRS University of Toulouse III UMR 5165 Epidermis differentiation and rheumatoid autoimmunity, Institut Fédératif de Recherche 30 INSERM CNRS Centre Hospitalier Universitaire de Toulouse Université Paul Sabatier, Toulouse Cedex, France
    J Invest Dermatol 125:34-41. 2005
    ..anagen hair follicles, PAD1 and 2, in arrector pili muscles and sweat glands, whereas no PAD were detected in sebaceous glands. PAD1 was detected in the cuticle and the Huxley layer of the inner root sheath (IRS), and in the companion ..
  95. ncbi Investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris
    E D Seaton
    Department of Dermatology, Hammersmith Hospital, Imperial College, London W12 0NN, UK
    Br J Dermatol 155:748-55. 2006
    ..The mechanism of nonablative lasers in inflammatory acne is variously suggested to be damage either to sebaceous glands or to Propionibacterium acnes. Their effects on cytokine production are unknown.
  96. ncbi Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland
    J J Bull
    Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary College, London E1 2AT, UK
    Br J Dermatol 152:1125-33. 2005
    ..The oncoprotein c-Myc is a key regulator of these events in epidermal keratinocytes, but its importance in the hair growth cycle has not previously been determined...
  97. ncbi Extramammary Paget's disease--a proliferation of adnexal origin?
    S Regauer
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Histopathology 48:723-9. 2006
    ..Cytokeratin (CK) 15 and CK19 are considered markers for follicular stem cells located in the hair follicle bulge region...
  98. ncbi The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3
    F Runkel
    Department of Anatomy, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Genomics 84:824-35. 2004
    ..We infer a role of Gsdm3 during the catagen to telogen transition at the end of hair follicle morphogenesis and the formation of hair follicle-associated sebaceous glands.
  99. ncbi Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation
    Mohamed E Salama
    Department of Pathology, Henry Ford Hospital, Detroit, Mich 48202, USA
    Arch Pathol Lab Med 128:986-90. 2004
    ..Chondroid syringoma (CS) is a benign cutaneous adnexal tumor with epithelial and stromal components. Epithelial components derived from folliculo-sebaceous-apocrine germ are evident in apocrine but not in eccrine CS...
  100. pmc The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling
    Desmond J Tobin
    Department of Biomedical Sciences, University of Bradford, Bradford, England
    Am J Pathol 160:1807-21. 2002
    ..Principal target tissues that may contain protein substrate(s) for this cysteine protease include the developing hair cone, inner root sheath, anchoring apparatus of the telogen club, and organelles of lysosomal origin (eg, melanosomes)...
  101. ncbi Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles
    Sonja Ständer
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:42-51. 2002
    ..In conclusion, preserved MC-1R expression in adnexal epithelia suggests a functional role of proopiomelanocortin (POMC) in various malformations and neoplasms of the skin...

Research Grants46

  1. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..application are as follows: 1) Optimize efficacy of topical liposomal 4-MA to selectively induce apoptosis of sebaceous glands of male hamsters; 2) Determine pharmacokinetics of topical liposomal 4- MA to hair follicles of human scalp ..
  2. MC5 RECEPTOR--REGULATION OF EXOCRINE GLAND FUNCTION
    ROGER CONE; Fiscal Year: 2003
    ..high levels of MC5-R in multiple exocrine tissues, including the Harderian, preputial, lacrimal, and sebaceous glands. The MC5-R is also required for the production of porphyrins by the Harderian gland, and regulation of ..
  3. HAIR FOLLICLE BULGE CELLS IN TUMORIGENESIS AND ALOPECIA
    George Cotsarelis; Fiscal Year: 2009
    ..cells have properties of stem cells, and isolated bulge cells can reconstitute hair follicles, epidermis and sebaceous glands. We have now identified a number of genes which we hypothesize maintain the stem cell phenotype...
  4. Identification and Characterization of Adult Salivary Gland Stem Cells
    Soosan Ghazizadeh; Fiscal Year: 2013
    ..a method for in situ lineage tracing that we used to demonstrate the presence of stem cells in epidermis and sebaceous glands. We also showed that these cells functioned independently of hair follicle stem cells located in the bulge...
  5. Cellular Determinants of Ah Receptor Signaling
    Thomas R Sutter; Fiscal Year: 2013
    ..and hyperkeratinization of cells of the hair follicle, as well as a metaplastic response of the ductular sebaceous glands. How AHR-mediated changes in gene expression lead to toxicity is not well understood for any organ system ..
  6. Skin Stem Cells: Purification and Characterization
    Elaine Fuchs; Fiscal Year: 2013
    ..During injury, HF-SCs participate with basal IFE SCs to repair damaged epidermis and sebaceous glands. Both basal IFE SCs and HF-SCs can be cultured and propagated long-term outside their native niches under ..
  7. Antimicrobial Lipids within the Oral Cavity
    PHILIP WESLEY WERTZ; Fiscal Year: 2010
    ..and are carried to the surface as cells differentiate, while others are secreted onto the surface from sebaceous glands. Published reports and preliminary data indicate that free sphingoid bases have broad antimicrobial activity, ..
  8. Mitochondrial ROS Regulate Skin and Hair Homeostasis
    Navdeep S Chandel; Fiscal Year: 2012
    ..In order to maintain its protective function, epidermis and its appendages the hair follicles (HF) and sebaceous glands (SG) undergo continual homeostatic renewal...
  9. Role of Cilia/IFT in Skin and Hair
    Bradley K Yoder; Fiscal Year: 2012
    ..cells in the skin and hair follicle resulted in a very unexpected phenotype (hyperproliferation of skin and sebaceous glands, epidermal downgrowths into the dermis, and altered hair alignment), which is consistent with overactivation ..
  10. Neutrophil gelatinase-associated lipocalin mediated retinoid effects in the skin
    KIMBERLY R LUMSDEN; Fiscal Year: 2010
    ..The overall goal of this investigation is to determine if the effects of 13-cis RA in inducing apoptosis in sebaceous glands is mediated by NGAL...
  11. Hair Follicle Neogenesis in Response to Wounding
    George Cotsarelis; Fiscal Year: 2013
    ..We demonstrated that adult mice have the capacity to regenerate hair follicles, sebaceous glands and fat following a full thickness wound...
  12. STEROID 5 ALPHA REDUCTASE--STRUCTURE/FUNCTION
    Shutsung Liao; Fiscal Year: 2000
    ..in culture, testosterone-induced accessory sex gland growth in rats and androgen-dependent growth of hamster sebaceous glands. The effect of these 5a-reductase inhibitors on the growth of androgen-dependent human prostate tumors ..
  13. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2005
    ..nestin-expressing hair-follicle stem cells are located in the permanent upper hair follicle right below the sebaceous glands and above the errector pili muscle in the follicle bulge area...
  14. ANDROGEN REGULATION OF HUMAN SEBACEOUS GLANDS
    Diane Thiboutot; Fiscal Year: 2001
    ....
  15. SEBACEOUS GLANDS, ACNE AND ANDROGEN METABOLISM
    PETER POCHI; Fiscal Year: 1980
    ....
  16. LASER TREATMENT OF ACNE BY INJURY TO SEBACEOUS GLANDS
    DILIP PAITHANKAR; Fiscal Year: 2000
    The objective of the proposed study is to investigate the feasibility of photothermally altering the sebaceous glands and interfering with sebum production while preserving the epidermis...
  17. Cyclic and Progressive Hair Loss in rough coat Mice
    Tongyu Cao; Fiscal Year: 2009
    ..By contrast, the sebaceous glands in rc mice are hypertrophic due to sebocyte hyperplasia...
  18. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
    ..The overall goal of this proposal is to understand the factors regulating the production of testosterone in women, particularly in their ovaries. ..
  19. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
    ....
  20. Role of PPAR Gamma Amino-Terminus in the Adipocyte
    Dianne Deplewski; Fiscal Year: 2007
    ..3) To use transgenic techniques to develop mice with a Ser112Ala mutation in PPARgamma2. The degree of obesity and insulin sensitivity will be further studied in these mice. ..
  21. Osteopontin and microenvironment of initiated cells
    Pi Ling Chang; Fiscal Year: 2010
    ..These proposed in vivo and in vitro studies will shed light on the molecular mechanism(s) by which a matricellular protein enhances the survival of transforming cells during early tumor promotion. ..
  22. Assessment of Hypoxia in Malignant Gliomas Using EF5
    Sydney Evans; Fiscal Year: 2002
    ..We project that we will be able to institute clinical EF5 PET studies at PENN in patients with brain tumors in approximately 2 years, corresponding to the time that much of the data from the studies proposed herein will mature. ..
  23. A Study of Biological Function of Basonuclin
    George Cotsarelis; Fiscal Year: 2010
    ..The role of Bnc's in the EGFr pathway will be discerned. The studies will impact on understanding stem cell biology and the role of Bnc's in wound healing, hair cycling and skin regeneration. ..
  24. NEUROTROPHIN EFFECTS ON PERIPHERAL NERVE DEVELOPMENT
    Frank Rice; Fiscal Year: 2001
    ..These studies should enhance our understanding of the role of neurotrophins and their receptors in regulating the development of specific types cutaneous innervation. ..
  25. LEF/TCF Function in Adult Stem Cell Fate and Tumorigenesis
    Stephen R Lyle; Fiscal Year: 2010
    ....
  26. DOES HYPOXIA PREDICT RADIATION/SURGICAL TUMOR RESPONSE?
    Sydney Evans; Fiscal Year: 2005
    ..Primary endpoints of survival analyses will be metastasis in soft tissue sarcoma patients and local- regional recurrence in head and neck squamous cell carcinoma patients. ..
  27. MAP KINASES REGULATE INVOLUCRIN GENE EXPRESSION
    Richard L Eckert; Fiscal Year: 2010
    ..It is hoped that a better understand of this cascade will lead to new and effective therapies for epidermal disease. ..
  28. A Female Mouse Model to Study Recurrent Genital Herpes
    Margaret Parr; Fiscal Year: 2002
    ..abstract_text> ..
  29. Microenvironment: Imaging/Implications in Brain Tumors
    Sydney Evans; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  30. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..The goal of Specific Aim 4 is to identify these target proteins using ligand blots, co-immunoprecipitation, affinity chromatography, and protein microsequencing. ..
  31. Chemoprevention in an inducible mouse melanoma model
    REMCO SPANJAARD; Fiscal Year: 2004
    ..abstract_text> ..
  32. Role of Osteopontin in Tumor Promotion
    Pi Ling Chang; Fiscal Year: 2005
    ..Together, these studies will provide a better understanding of the role of OPN in tumor promotion and may contribute to the design of a mechanism-based strategy for cancer prevention. ..
  33. Evaluation of Hypoxia by EF5 Binding in Cervix Cancer
    Sydney Evans; Fiscal Year: 2003
    ..This will allow conversion of binding to tumor pO2. Further analyses will incorporate the area of tissue involved at various binding levels. Patient follow-up and statistical evaluations will be provided by the GOG. ..
  34. SPECTROSCOPIC AND RELATED STUDIES ON LENS MEMBRANE LIPID
    Douglas Borchman; Fiscal Year: 2003
    ..An understanding of these alterations will facilitate the development of therapies to prevent or perhaps even reverse these changes. ..
  35. RETINOIC ACID RECEPTOR GAMMA SPECIFIC SIGNALING IN MELAN
    REMCO SPANJAARD; Fiscal Year: 2004
    ..The result from these studies will allow the integration of the 3-D structure of RARg with its molecular and biological actions in relation to an important disease. ..
  36. GREEN TEA POLYPHENOL CHEMOPREVENTION IN KERATINOCYTES
    RICHARD ECKERT; Fiscal Year: 2006
    ..The central goal of this proposal is to gain new information regarding the mechanism of EGCG action. It is hoped that these studies lead to the design of new strategies for enhancing the effectiveness of these agents. ..
  37. HUMAN INVOLUCRIN GENE IN TRANSGENIC MICE
    RICHARD ECKERT; Fiscal Year: 2006
    ..These studies are designed to provide important new insights regarding the mechanisms that regulate gene expression during epidermal differentiation. ..
  38. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  39. KERATINOCYTE DIFFERENTIATION REGULATOR
    RICHARD ECKERT; Fiscal Year: 2008
    ..Specific Aim 3 is designed to assess the importance of TIG3 subcellular distribution for function, and Specific Aim 4 is designed to investigate the TIG3 role in vivo. ..
  40. The Chronobiology of Cohabitation
    Matthew Paul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. Transgenic Mouse Model for Barrett's Esophagus
    George Cotsarelis; Fiscal Year: 2003
    ..This would be the first transgenic inducible injury model that mimics Barrett's esophagus. It should be a valuable resource for those interested in studying the pathogenesis, chemoprevention and treatment of Barrett's esophagus. ..