urothelium

Summary

Summary: The epithelial lining of the URINARY TRACT.

Top Publications

  1. ncbi Uroplakin gene expression by normal and neoplastic human urothelium
    E D Lobban
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds, United Kingdom
    Am J Pathol 153:1957-67. 1998
  2. ncbi Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux
    P Hu
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology, New York, New York 10016, USA
    J Cell Biol 151:961-72. 2000
  3. ncbi Gemcitabine plus cisplatin versus gemcitabine plus carboplatin as first-line chemotherapy in advanced transitional cell carcinoma of the urothelium: results of a randomized phase 2 trial
    Luigi Dogliotti
    Unit of Medical Oncology, University of Torino, San Luigi Hospital, Orbassano Torino, Italy
    Eur Urol 52:134-41. 2007
  4. ncbi Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    Shugo Suzuki
    Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Toxicol Sci 113:349-57. 2010
  5. ncbi Urothelial carcinomas arising in arsenic-contaminated areas are associated with hypermethylation of the gene promoter of the death-associated protein kinase
    W T Chen
    Department of Pathology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Histopathology 51:785-92. 2007
  6. ncbi Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells
    Ana Charrua
    Institute of Histology and Embryology, Instituto de Ciencias Biomedicas Abel Salazar, University of Porto, Porto, Portugal
    J Urol 182:2944-50. 2009
  7. ncbi No evidence for involvement of beta-catenin and APC in urothelial carcinomas
    Robert Stoehr
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Int J Oncol 20:905-11. 2002
  8. ncbi Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation
    Z T Zhang
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 20:1973-80. 2001
  9. ncbi Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes
    Yanru Chen
    Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:14012-7. 2003
  10. ncbi P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis
    H V Tempest
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    BJU Int 93:1344-8. 2004

Research Grants

  1. Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography
    Yingtian Pan; Fiscal Year: 2007
  2. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
  3. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
  4. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
  5. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2007
  6. Glycosaminoglycans For IC Pathophysiology and Prognosis
    Vinata Lokeshwar; Fiscal Year: 2005
  7. Regulaton of Urothelial Growth
    Tung Tien Sun; Fiscal Year: 2007
  8. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2007
  9. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2009
  10. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George A Kuchel; Fiscal Year: 2010

Detail Information

Publications217 found, 100 shown here

  1. ncbi Uroplakin gene expression by normal and neoplastic human urothelium
    E D Lobban
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds, United Kingdom
    Am J Pathol 153:1957-67. 1998
    ..Normal urothelium expressed mRNA for all four uroplakins, although UPIII could be detected only by ribonuclease protection assay...
  2. ncbi Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux
    P Hu
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology, New York, New York 10016, USA
    J Cell Biol 151:961-72. 2000
    b>Urothelium synthesizes a group of integral membrane proteins called uroplakins, which form two-dimensional crystals (urothelial plaques) covering >90% of the apical urothelial surface...
  3. ncbi Gemcitabine plus cisplatin versus gemcitabine plus carboplatin as first-line chemotherapy in advanced transitional cell carcinoma of the urothelium: results of a randomized phase 2 trial
    Luigi Dogliotti
    Unit of Medical Oncology, University of Torino, San Luigi Hospital, Orbassano Torino, Italy
    Eur Urol 52:134-41. 2007
    ..of gemcitabine-cisplatin (GP) and gemcitabine-carboplatin (GC) in patients with advanced transitional cell carcinoma of the urothelium (TCC), with the main objective to demonstrate a reduction in toxicity of at least 25% in the GC arm.
  4. ncbi Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    Shugo Suzuki
    Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Toxicol Sci 113:349-57. 2010
    ..This strongly supports the previous conclusion in studies with muraglitazar that this is a rat-specific phenomenon and does not pose a urinary bladder cancer risk to humans treated with these agents...
  5. ncbi Urothelial carcinomas arising in arsenic-contaminated areas are associated with hypermethylation of the gene promoter of the death-associated protein kinase
    W T Chen
    Department of Pathology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Histopathology 51:785-92. 2007
    ..The aim was to determine whether hypermethylation of death-associated protein kinase (DAPK) gene is associated with chronic arsenic exposure...
  6. ncbi Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells
    Ana Charrua
    Institute of Histology and Embryology, Instituto de Ciencias Biomedicas Abel Salazar, University of Porto, Porto, Portugal
    J Urol 182:2944-50. 2009
    ..We investigated the expression and functional status of TRPV1 receptor in human urothelial cells...
  7. ncbi No evidence for involvement of beta-catenin and APC in urothelial carcinomas
    Robert Stoehr
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Int J Oncol 20:905-11. 2002
    ..Other wnt pathway members, such as axin, may play an important role in urothelial carcinogenesis...
  8. ncbi Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation
    Z T Zhang
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 20:1973-80. 2001
    ..Using a urothelium-specific promoter of the uroplakin II gene, we showed earlier in transgenic mice that the urothelial expression ..
  9. ncbi Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes
    Yanru Chen
    Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:14012-7. 2003
    ..1% of total protein) in urothelium, whereas Rab27b levels were greatly reduced (to <5% of normal urothelium) in cultured urothelial cells, which ..
  10. ncbi P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis
    H V Tempest
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    BJU Int 93:1344-8. 2004
    ..the expression of P2X(3) receptors (implicated in the pathophysiology of pain) is altered in human bladder urothelium from patients with interstitial cystitis (IC, a major symptom of which is pain), and as P2X(2) receptors can be ..
  11. ncbi Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
    Peter J Goebell
    Department of Urology, University Clinic of Erlangen, Erlangen, Germany
    Urol Oncol 28:409-28. 2010
    ..The molecular pathogenesis of high-grade noninvasive papillary tumors and of T1 tumors is not yet clear, and possibilities are discussed...
  12. ncbi Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
    Erika M Wolff
    Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Res 70:8169-78. 2010
    ..patterns between noninvasive and invasive UC and the DNA methylation patterns between normal-appearing urothelium from bladders with cancer and urothelium from cancer-free bladders...
  13. ncbi Cell biology and physiology of the uroepithelium
    Puneet Khandelwal
    Univ of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 297:F1477-501. 2009
    ..Finally, we describe potential mechanisms by which the uroepithelium can transmit information about the urinary space to the other tissues in the bladder proper...
  14. ncbi Golgi apparatus fragmentation as a mechanism responsible for uniform delivery of uroplakins to the apical plasma membrane of uroepithelial cells
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    Biol Cell 102:593-607. 2010
    ..We have used the culture model of UCs with the capacity to undergo terminal differentiation to study the process of uniform delivery of DFVs to the APM and to elucidate the mechanisms involved...
  15. ncbi Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function
    Birthe Schnegelsberg
    Department of Neuroscience, Roche Palo Alto, Palo Alto, California, USA
    Am J Physiol Regul Integr Comp Physiol 298:R534-47. 2010
    ..sensory function, we generated a transgenic mouse model of chronic NGF overexpression in the bladder using the urothelium-specific uroplakin II (UPII) promoter...
  16. ncbi Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients
    Hiroshi Tsuruta
    Department of Urology, Akita University School of Medicine, Akita, Japan
    Cancer Res 66:8389-96. 2006
    PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate an urothelium-specific null mutation of Pten in mice [FabpCrePten(flox/flox) (FPten(flox/flox)) mice]...
  17. ncbi Characterization of the purinergic receptor subtype on guinea-pig suburothelial myofibroblasts
    Gui Ping Sui
    Institute of Urology, University College London, London, UK
    BJU Int 97:1327-31. 2006
    ....
  18. ncbi Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer
    Fiona M Platt
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, United Kingdom
    Clin Cancer Res 15:6008-17. 2009
    ..Our aim was to assess the frequency and distribution of pathway alterations in bladder cancer...
  19. ncbi The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis
    Grannum R Sant
    Department of Urology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Urology 69:34-40. 2007
    ....
  20. ncbi Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway
    E J Chapman
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Oncogene 25:5037-45. 2006
    ..The production of genetically normal but immortal NHUC lines now provides a valuable platform for experiments to examine the timing and combination of events necessary for UCC tumorigenesis...
  21. ncbi ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells
    Edward C Y Wang
    Renal Electrolyte Division and Laboratory of Epithelial Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 115:2412-22. 2005
    ....
  22. ncbi Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases
    Xiang Tian Kong
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 167:1195-204. 2004
    The apical surface of mouse urothelium is covered by two-dimensional crystals (plaques) of uroplakin (UP) particles. To study uroplakin function, we ablated the mouse UPII gene...
  23. ncbi Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability
    Ping Hu
    Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, NY 10016, USA
    Am J Physiol Renal Physiol 283:F1200-7. 2002
    ..J Cell Biol 151: 961-972, 2000). Our results indicate that normal mouse urothelium exhibits high transepithelial resistance and low urea and water permeabilities...
  24. ncbi Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines
    Darren C Tomlinson
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, United Kingdom
    Cancer Res 65:10441-9. 2005
    ..FGFR3 was identified as the major family member expressed in both normal human urothelium and cultured normal human urothelial (NHU) cells and was expressed as the IIIb isoform...
  25. ncbi Urothelial plaque formation in post-Golgi compartments
    Samo Hudoklin
    Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 6:e23636. 2011
    ..With additional fusions and buddings, iFVs mature into mFVs, each carrying two urothelial plaques toward the apical surface of the umbrella cell...
  26. ncbi Generation of a functional, differentiated porcine urothelial tissue in vitro
    Alexander M Turner
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York, United Kingdom
    Eur Urol 54:1423-32. 2008
    The primary function of urothelium is to serve as a physical urinary barrier. This function is dependent on features expressed at the molecular level that are acquired during cytodifferentiation...
  27. ncbi Directed differentiation of embryonic stem cells into bladder tissue
    Siam Oottamasathien
    Department of Urologic Surgery, Vanderbilt University Medical Center, and Division of Pediatric Urology, Vanderbilt Children s Hospital Nashville, TN 37232 2765, USA
    Dev Biol 304:556-66. 2007
    ..This model allows us to visualize the various stages in the differentiation of urothelium from ES cells, including the commitment to an endodermal cell lineage, with the temporal profile characterized ..
  28. ncbi Colistin interactions with the mammalian urothelium
    Jamie R Lewis
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555-0641, USA
    Am J Physiol Cell Physiol 286:C913-22. 2004
    ..Addition of colistin to the mucosal solution of the rabbit urinary bladder epithelium (urothelium) resulted in an increase in the transepithelial conductance...
  29. ncbi The uroepithelium: not just a passive barrier
    Gerard Apodaca
    Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Traffic 5:117-28. 2004
    ....
  30. ncbi The 2004 WHO classification of bladder tumors: a summary and commentary
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Int J Surg Pathol 13:143-53. 2005
    ..This scheme is meant to replace the 1973 WHO classification, but the use of both the 1973 and the latest WHO classifications is recommended until the latter is sufficiently validated...
  31. ncbi Gene deletion in urothelium by specific expression of Cre recombinase
    Lan Mo
    Dept of Urology, New York University Cancer Institute, New York Univ School of Medicine, New York, New York, USA
    Am J Physiol Renal Physiol 289:F562-8. 2005
    b>Urothelium that lines almost the entire urinary tract acts as a permeability barrier and is involved in the pathogenesis of major urinary diseases, including urothelial carcinoma, urinary tract infection, and interstitial cystitis...
  32. ncbi Differentiation of epithelial cells in the urinary tract
    Rok Romih
    Medical Faculty, Institute of Cell Biology, Ljubljana, Slovenia
    Cell Tissue Res 320:259-68. 2005
    ..epithelium covering the outer band of the outer medulla gradually changed from a two-layered to a three-layered urothelium with typical umbrella cells that contained all four uroplakins...
  33. ncbi Keratinizing squamous metaplasia of the bladder: a review
    Imran Ahmad
    Beatson Institute for Cancer Research, Glasgow, UK
    Urol Int 81:247-51. 2008
    ..Once diagnosed, there is a dilemma how to treat and follow-up this group...
  34. ncbi Interstitial cells in the urinary bladder--localization and function
    Karen D McCloskey
    School of Medicine, Dentistry and Biomedical Sciences, Medical Biology Centre, Belfast, Northern Ireland, UK
    Neurourol Urodyn 29:82-7. 2010
    ..This review summarizes the currently available literature on the localization and proposed functions of a novel group of cells in the urinary bladder known as interstitial cells or interstitial cells of Cajal (ICC)...
  35. ncbi Temporally and spatially controllable gene expression and knockout in mouse urothelium
    Haiping Zhou
    Departments of Urology, New York Univ School of Medicine, New York, 10010, USA
    Am J Physiol Renal Physiol 299:F387-95. 2010
    b>Urothelium that lines almost the entire urinary tract performs important functions and is prone to assaults by urinary microbials, metabolites, and carcinogens...
  36. ncbi Formation and maintenance of blood-urine barrier in urothelium
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Lipiceva 2, SI 1000, Ljubljana, Slovenia
    Protoplasma 246:3-14. 2010
    ..In this review, we discuss recent discoveries on the role of tight junctions, dynamics of Golgi apparatus and post-Golgi compartments, and intracellular membrane traffic during the biogenesis and maintenance of blood-urine barrier...
  37. ncbi Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome
    Jia Heng Shie
    Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    BJU Int 108:E136-41. 2011
    ..To investigate the relationships between suburothelial inflammation and urothelial dysfunction in interstitial cystitis/painful bladder syndrome (IC/PBlS)...
  38. ncbi Biology of urothelial tumorigenesis: insights from genetically engineered mice
    Xue ru Wu
    Department of Urology and Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Metastasis Rev 28:281-90. 2009
    b>Urothelium, one of the slowest cycling epithelia in the body, embodies a unique biological context for cellular transformation...
  39. ncbi Antigenic and ultrastructural markers associated with urothelial cytodifferentiation in primary explant outgrowths of mouse bladder
    Mateja Erdani Kreft
    Medical Faculty, Institute of Cell Biology, Ljubljana, Slovenia
    Cell Biol Int 26:63-74. 2002
    ..When examined at the ultrastructural level, the cultured urothelium was polarized and organized as a multilayered epithelium...
  40. ncbi All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms
    Joshua R Mauney
    Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts, USA
    PLoS ONE 5:e11513. 2010
    The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that acts as a specialized permeability barrier that protects the underlying tissue from urine via expression of a highly specific group of ..
  41. ncbi Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder
    M R Freeman
    Urology Research, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 99:1028-36. 1997
    ..HER1) has been implicated in regenerative growth and proliferative diseases of the human bladder epithelium (urothelium), however a cognate HER1 ligand that can act as a growth factor for normal human urothelial cells (HUC) has not ..
  42. ncbi Removal of urothelium affects bladder contractility and release of ATP but not release of NO in rat urinary bladder
    Alvaro Munoz
    Scott Department of Urology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    BMC Urol 10:10. 2010
    The objective of our work was to investigate both the contractile function and the release of ATP and NO from strips of bladder tissue after removal of the urothelium.
  43. ncbi Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle
    Guangwei Min
    Structural Biology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Sci 116:4087-94. 2003
    ..Our results also have implications for the transmembrane signal transduction in urothelial cells as induced by the binding of uropathogenic E. coli to its uroplakin receptor...
  44. ncbi Behavior of urothelial carcinoma with respect to anatomical location
    J W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 177:1715-20. 2007
    Urothelial carcinoma is a disease of the entire urothelium. Recent molecular insights suggest that the biology of some upper urinary tract and bladder urothelial carcinoma differ. These differences may affect tumor phenotype...
  45. ncbi In vitro release of adenosine triphosphate from the urothelium of human bladders with detrusor overactivity, both neurogenic and idiopathic
    Vivek Kumar
    Department of Reconstructive Urology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Eur Urol 57:1087-92. 2010
    ..There is increased evidence to suggest a role for nonadrenergic-noncholinergic neurotransmission in the pathogenesis of bladder dysfunction...
  46. ncbi A phase II trial of pemetrexed plus gemcitabine in locally advanced and/or metastatic transitional cell carcinoma of the urothelium
    H von der Maase
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Ann Oncol 17:1533-8. 2006
    ..current study were to determine overall response rate (ORR), progression-free survival, overall survival and safety and toxicity in chemonaive patients with locally advanced and/or metastatic transitional cell carcinoma of the urothelium.
  47. ncbi [Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells]
    J Neuhaus
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
    Urologe A 46:1193-7. 2007
    ..The aim of the study is to define IL-6 target gene regulation in cultivated human detrusor smooth muscle cells...
  48. ncbi Enhanced adenosine triphosphate release from the urothelium of patients with painful bladder syndrome: a possible pathophysiological explanation
    Vivek Kumar
    Department of Urology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Urol 178:1533-6. 2007
    We established the level of adenosine triphosphate release by the urothelium in patients with painful bladder syndrome and compared it with that from the normal human bladder.
  49. ncbi Urinary bladder urothelium: molecular sensors of chemical/thermal/mechanical stimuli
    Lori A Birder
    University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Department of Medicine, Pittsburgh, PA 15261, United States
    Vascul Pharmacol 45:221-6. 2006
    ..These and other findings highlight the functional importance of the urinary bladder urothelium and suggest that perturbations in urothelial targets and/or cell-cell interactions may lead to a number of ..
  50. ncbi Apical plasma membrane traffic in superficial cells of bladder urothelium
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Ann N Y Acad Sci 1152:18-29. 2009
    ....
  51. ncbi Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment
    Alexander Roosen
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, UK
    Eur Urol 55:1440-8. 2009
    ..An increasing body of evidence suggests a possible role of suburothelial myofibroblasts (MFs) in bladder mechanosensation and in the pathophysiology of detrusor overactivity (DO)...
  52. ncbi Weekly paclitaxel and gemcitabine in advanced transitional-cell carcinoma of the urothelium: a phase II Hoosier Oncology Group study
    Jinxing Li
    Division of Hematology/Oncology and Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Oncol 23:1185-91. 2005
    ..However, because of the high incidence of pulmonary toxicity associated with this schedule of paclitaxel and gemcitabine, we recommend against the use of this regimen in this patient population...
  53. ncbi A surgical model of composite cystoplasty with cultured urothelial cells: a controlled study of gross outcome and urothelial phenotype
    M Fraser
    Department of Paediatric Urology, Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds, UK
    BJU Int 93:609-16. 2004
    ..Histological analysis showed that in four of five composite uterocystoplasties, the neo-urothelium was stratified and had a transitional morphology, although in some areas coverage was incomplete...
  54. ncbi Effects of PPAR agonists on proliferation and differentiation in human urothelium
    Claire L Varley
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York YO10 5YW, UK
    Exp Toxicol Pathol 60:435-41. 2008
    ..has indicated that they may invoke non-genotoxic carcinogenesis in the epithelial lining of the urinary tract (urothelium)...
  55. ncbi Involvement of vps33a in the fusion of uroplakin-degrading multivesicular bodies with lysosomes
    Xuemei Guo
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Traffic 10:1350-61. 2009
    The apical surface of the terminally differentiated mouse bladder urothelium is largely covered by urothelial plaques, consisting of hexagonally packed 16-nm uroplakin particles...
  56. ncbi Everything you wanted to know about the bladder epithelium but were afraid to ask
    S A Lewis
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555 0641, USA
    Am J Physiol Renal Physiol 278:F867-74. 2000
    The mammalian urinary bladder epithelium (urothelium) performs the important function of storing urine for extended periods, while maintaining the urine composition similar to that delivered by the kidneys...
  57. ncbi Uroplakins in urothelial biology, function, and disease
    Xue ru Wu
    Department of Urology, New York University Langone Medical Center, New York, USA
    Kidney Int 75:1153-65. 2009
    b>Urothelium covers the inner surfaces of the renal pelvis, ureter, bladder, and prostatic urethra...
  58. ncbi Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells
    Emma J Chapman
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds LS97TF, United Kingdom
    Mol Cancer Res 6:1154-68. 2008
    ..Our data supports the concept of both telomere-based and non-telomere effects of telomerase and provides further rationale for the use of telomerase inhibitors in UC...
  59. ncbi Focus on bladder cancer
    Colin P N Dinney
    Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, TX USA
    Cancer Cell 6:111-6. 2004
  60. ncbi Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis 46202, USA
    Cancer 101:957-62. 2004
    ..Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder...
  61. ncbi Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists
    A Kanai
    Department of Medicine, University of Pittsburgh School of Medicine, A1224 Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 292:F1065-72. 2007
    ..activity in neonatal bladders, unlike activity in adult bladders, is highly organized, originating in the urothelium-suburothelium near the dome...
  62. ncbi Stretch-regulated exocytosis/endocytosis in bladder umbrella cells
    Steven T Truschel
    Renal-Electrolyte Division, Department of Medicine, Laboratory of Epithelial Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Biol Cell 13:830-46. 2002
    ....
  63. ncbi Differential expression of functional cannabinoid receptors in human bladder detrusor and urothelium
    Vikas Tyagi
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    J Urol 181:1932-8. 2009
    ..Consequently we investigated the expression of functional cannabinoid 1 and 2 receptors in human bladder detrusor and urothelium.
  64. ncbi Directed differentiation of bone marrow derived mesenchymal stem cells into bladder urothelium
    Govindaraj Anumanthan
    Department of Urologic Surgery, Vanderbilt University Medical Center and Division of Pediatric Urology, Vanderbilt Children s Hospital, Nashville, Tennessee, USA
    J Urol 180:1778-83. 2008
    ..has the appropriate inductive signals to direct pluripotent mouse embryonic stem cells toward endodermal derived urothelium and develop mature bladder tissue...
  65. ncbi Confrontation of immunohistochemistry and fluorescent in situ hybridization for the assessment of HER-2/ neu (c-erbb-2) status in urothelial carcinoma
    Gonzague De Pinieux
    Service d'Anatomie Pathologique, , 27 rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
    Virchows Arch 444:415-9. 2004
    ..Patients with urothelial carcinomas overexpressing HER-2/ neu using IHC are potential candidates for targeted chemotherapy...
  66. ncbi Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium
    L A Birder
    Dept of Medicine, Laboratory of Epithelial Cell Biology, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Physiol Renal Physiol 285:F423-9. 2003
    ..IP3) receptors (thapsigargin, acetylcholine) release significantly more ATP in FIC compared with normal urothelium. Taken together, these results suggest that FIC results in a novel hypersensitivity to mechanical stimuli that ..
  67. ncbi Histological changes in the urothelium and suburothelium of human overactive bladder following intradetrusor injections of botulinum neurotoxin type A for the treatment of neurogenic or idiopathic detrusor overactivity
    Apostolos Apostolidis
    Institute of Neurology, UCL, London, United Kingdom
    Eur Urol 53:1245-53. 2008
    We examined, for the first time in a prospective study, the histological changes in the urothelium and suburothelium of patients with neurogenic (NDO) or idiopathic detrusor overactivity (IDO) after one or repeat treatments with ..
  68. ncbi Palliative chemotherapy with gemcitabine, paclitaxel, and cisplatin as first-line treatment following gemcitabine monotherapy for patients with transitional cell carcinoma of the urothelium
    T H Ecke
    Department of Urology, HELIOS Hospital, Bad Saarow, Germany
    Minerva Urol Nefrol 61:1-8. 2009
    Chemotherapeutic agents are active in transitional cell cancer of the urothelium, and combinations have shown promising results...
  69. ncbi Urothelial lesions with inverted growth patterns: histogenesis, molecular genetic findings, differential diagnosis and clinical management
    Kurt B Hodges
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    BJU Int 107:532-7. 2011
    ..Some are so common that they are considered normal variants of urothelium, whereas others are rare...
  70. ncbi Immortalized human urothelial cells as a model of arsenic-induced bladder cancer
    K E Eblin
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA
    Toxicology 248:67-76. 2008
    ..through epidemiological evidence, and UROtsa cells, a normal, immortalized cell culture model of human urothelium, have proven to be a good model for the bladder epithelium...
  71. ncbi Maturation of the Golgi apparatus in urothelial cells
    Samo Hudoklin
    Institute of Cell Biology, Medical Faculty, Lipiceva 2, 1000, Ljubljana, Slovenia
    Cell Tissue Res 336:453-63. 2009
    ..In normal urothelium, immature basal cells have a simple GA, which is small and distributed close to the nucleus...
  72. ncbi Prostaglandin receptor EP1 and EP2 site in guinea pig bladder urothelium and lamina propria
    Mohammad Sajjad Rahnama'i
    Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Urol 183:1241-7. 2010
    b>Urothelium has 2 main functions. It is a barrier to urine and has a sensory role. In response to stretch urothelium releases various substances that modulate afferent nerve activity...
  73. ncbi Establishment and characterization of primary and subsequent subcultures of normal mouse urothelial cells
    M E Kreft
    Institute of Cell Biology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    Folia Biol (Praha) 51:126-32. 2005
    ..The NMU were harvested by two methods, directly from the urothelium in vivo and indirectly from the urothelial outgrowths of bladder explant cultures...
  74. ncbi Prognostic value of histopathological tumour growth patterns at the invasion front of T1G3 urothelial carcinoma of the bladder
    Stefan Denzinger
    Department of Urology, University of Regensburg, Regensburg, Germany
    Scand J Urol Nephrol 43:282-7. 2009
    ..The aim of this study was to evaluate this aspect in a series of primary T1G3 BC...
  75. ncbi Activation of alpha1D adrenergic receptors in the rat urothelium facilitates the micturition reflex
    Hiroko Ishihama
    Department of Neurophysiology, Akita University, School of Medicine, Akita, Japan
    J Urol 175:358-64. 2006
    ..We determined if alpha(1D) adrenergic receptors are expressed in the urothelium of the rat bladder and if inhibition of these receptors affects reflex voiding...
  76. ncbi Terminal urothelium differentiation of engineered neoureter after in vivo maturation in the "omental bioreactor"
    Herve Baumert
    Department of Urology, Paris Saint Joseph Hospital Trust, Paris, France
    Eur Urol 52:1492-8. 2007
    ..Avoidance of such inflammation requires a well-differentiated urothelium. We investigated whether omental maturation of a seeded construct in a pig model could achieve terminal ..
  77. ncbi Clinical utility of immunohistochemistry in the diagnoses of urinary bladder neoplasia
    Kurt B Hodges
    Department of Pathology and Laboratory Medicine Urology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Appl Immunohistochem Mol Morphol 18:401-10. 2010
    ..Emphasis is placed on panels of commonly used biomarkers to establish diagnoses...
  78. ncbi Morphological diagnosis of urothelial neoplasms
    R Montironi
    Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    J Clin Pathol 61:3-10. 2008
    ..The WHO 2004 classification is currently used. However, the WHO 1973 classification is still considered by many urologists and oncologists as the international standard in patient management...
  79. ncbi Qualitative and quantitative expression profile of muscarinic receptors in human urothelium and detrusor
    Shachi Tyagi
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Urol 176:1673-8. 2006
    ..of receptor subtypes expressed by human detrusor and its primary culture with the expression profile in a human urothelium immortalized cell line, and in fresh urothelium tissue and its primary cell culture...
  80. ncbi Inverted papilloma of the urinary bladder: a molecular genetic appraisal
    Ming-Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 19:1289-94. 2006
    ....
  81. ncbi Cadherin-11 up-regulation in overactive bladder suburothelial myofibroblasts
    Alexander Roosen
    Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom
    J Urol 182:190-5. 2009
    ....
  82. ncbi The immortalized UROtsa cell line as a potential cell culture model of human urothelium
    M R Rossi
    Genetics and Developmental Biology Program, West Virginia University, Morgantown, West Virginia, USA
    Environ Health Perspect 109:801-8. 2001
    The UROtsa cell line was isolated from a primary culture of normal human urothelium through immortalization with a construct containing the SV40 large T antigen...
  83. ncbi Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments: a pilot study
    Ashraf T Hafez
    Division of Urology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Urol 169:2316-9; discussion 2320. 2003
    PURPOSE: We developed a cell transfer technology for covering demucosalized colonic segments with bladder urothelium. This covering would be achieved through aerosol spraying of single cell suspension of bladder urothelial and smooth ..
  84. ncbi A study of cytokeratin 20 immunostaining in the urothelium of neuropathic bladder of patients with spinal cord injury
    Subramanian Vaidyanathan
    Regional Spinal Injuries Centre, District General Hospital, Southport PR8 6PN, UK
    BMC Urol 2:7. 2002
    Normal urothelium is characterised by terminally differentiated superficial cells, which express cytokeratin 20 in the cytoplasm...
  85. ncbi The scaffold protein IB1/JIP-1 controls the activation of JNK in rat stressed urothelium
    Thomas Tawadros
    Department of Internal Medicine, Service of Urology, University Hospital, CHUV-1011 Lausanne, Switzerland
    J Cell Sci 115:385-93. 2002
    ..The functional role of IB1/JIP-1 in the urothelium was therefore studied in vivo in a model of complete rat bladder outlet obstruction...
  86. ncbi Phase II study of cisplatin and paclitaxel in advanced carcinoma of the urothelium: an Eastern Cooperative Oncology Group Study
    R Dreicer
    Departments of Hematology Oncology and Urology, The Cleveland Clinic Foundation, Cleveland, OH, USA
    J Clin Oncol 18:1058-61. 2000
    ..Cisplatin and paclitaxel are active agents in advanced urothelial cancer. A phase II trial of this combination was performed to determine the activity and toxicity of these agents in a multi-institutional setting...
  87. ncbi The modern management of upper tract urothelial cancer: surgical treatment
    Mario Fernández Arancibia
    Department of Urology, University Hospital Mannheim, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    BJU Int 99:978-81. 2007
  88. ncbi EGFR expression in urothelial carcinoma of the upper urinary tract is associated with disease progression and metaplastic morphology
    Sebastian Leibl
    Department of Pathology, Medical University of Graz, Graz, Austria
    APMIS 116:27-32. 2008
    ..Since UCs with metaplastic morphology have been shown to be more resistant to conventional radiotherapy or chemotherapy, the strikingly strong EGFR expression in these tumours may offer a new perspective for affected patients...
  89. ncbi Immunoreactivity of p63 in monolayered and in vitro stratified human urothelial cell cultures compared with native urothelial tissue
    Gerhard Feil
    Department of Urology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Eur Urol 53:1066-72. 2008
    ..To investigate the immunoreactivity of p63 in monolayered and stratified human urothelial cell cultures and in normal urothelial tissues to assess the differentiation status of in vitro stratified urothelial constructs...
  90. ncbi [So-called "superficial" bladder tumors. Which classification in 2003? Part 2: Flat urothelial lesions]
    Mathilde Sibony
    Service d Anatomie Pathologique, CHU Saint Antoine, Hopital Tenon, 4 rue de la Chine, 75020 Paris
    Ann Pathol 23:35-45. 2003
    ....
  91. ncbi Case report: percutaneous management of transitional-cell carcinoma of the upper urinary tract using the bipolar resectoscope
    Douglas W Storm
    Department of Urology, Geisinger Clinic and Medical Center, Danville, Pennsylvania 17822, USA
    J Endourol 21:1011-3. 2007
    ..We present our initial experience using the bipolar resectoscope with saline irrigation in the management of renal transitional-cell carcinoma (TCC)...
  92. ncbi A phase II trial of cisplatin, fixed dose-rate gemcitabine and gefitinib for advanced urothelial tract carcinoma: results of the Cancer and Leukaemia Group B 90102
    George K Philips
    Vermont Cancer Center, Burlington, VT, USA
    BJU Int 101:20-5. 2008
    ....
  93. ncbi Gemcitabine plus docetaxel as first-line biweekly therapy in locally advanced and/or metastatic urothelial carcinoma: a phase II study
    Bruno Neri
    Department of Oncology, Centre of Experimental and Clinical Oncology, University of Florence, Florence, Italy
    Anticancer Drugs 18:1207-11. 2007
    ..Once data are confirmed in a larger study and longer follow-up, the favorable toxicity profile of this regimen may offer an interesting alternative to the cisplatin-based regimen...
  94. ncbi Phase II trial of gemcitabine and docetaxel in patients with advanced carcinoma of the urothelium: a trial of the Eastern Cooperative Oncology Group
    Robert Dreicer
    Department of Hematology Oncology and the Urologic Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Cancer 97:2743-7. 2003
    ..A Phase II trial of this combination was performed to determine the activity and toxicity of these agents in a multiinstitutional setting in patients previously treated with one prior chemotherapy regimen...
  95. ncbi Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation
    Andrew Fong
    Department of Pathology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Clin Pathol 120:93-100. 2003
    ..Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2...
  96. ncbi Upper tract urothelial recurrence following radical cystectomy for transitional cell carcinoma of the bladder: an analysis of 1,069 patients with 10-year followup
    Kristin M Sanderson
    Department of Urology, Keck School of Medicine, University of Southern California, University of Southern California Norris Cancer Center, Los Angeles, CA, USA
    J Urol 177:2088-94. 2007
    ..We reviewed our population of patients who underwent radical cystectomy to identify prognostic factors and clinical outcomes associated with upper tract recurrence...
  97. ncbi Detection of residual tumor cells in bladder biopsy specimens: pitfalls in the interpretation of cytokeratin stains
    Ecaterina F Tamas
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 31:390-7. 2007
    ..When interpreting CK stains for the detection of residual tumor cells, one should pay attention to the nature of the cells and not assume all CK staining cells are residual tumor cells...
  98. ncbi Florid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma
    Keith E Volmar
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 27:1243-52. 2003
    ..The findings underscore the importance of morphologic assessment in the distinction of florid von Brunn nests and nested variant of urothelial carcinoma...
  99. ncbi Lipoid-cell variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of five cases
    Xavier Leroy
    Department of Pathology, University Hospitals, Lille, France
    Am J Surg Pathol 31:770-3. 2007
    ..In the present series, the lipoid-cell variant of urothelial carcinoma was associated with an aggressive behavior and a poor prognosis...
  100. ncbi Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray
    John P T Higgins
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Surg Pathol 31:673-80. 2007
    ..We conclude that the detection of S100P and GATA3 protein expression may help distinguish urothelial carcinomas from other genitourinary neoplasms that enter into the differential diagnosis...
  101. ncbi Efficacy and safety of gemcitabine monotherapy in patients with transitional cell carcinoma after Cisplatin-containing therapy: a Japanese experience
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Jpn J Clin Oncol 37:201-6. 2007
    In Japan, the standard chemotherapy for advanced transitional cell carcinoma (TCC) of the urothelium is MVAC (methotrexate, vinblastine, adriamycin, cisplatin)...

Research Grants85

  1. Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography
    Yingtian Pan; Fiscal Year: 2007
    ..COCT allows noninvasive visualization of cross-sectional micro-morphology of urothelium and the underlying bladder wall (e.g...
  2. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..mimic the environment of chronic bladder inflammation and PBS/IC, mice with chronic overexpression of NGF in the urothelium (UPII-NGFv2) will be used to determine the role that NGF plays in mediating functional, neurochemical and ..
  3. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..mimic the environment of chronic bladder inflammation and PBS/IC, mice with chronic overexpression of NGF in the urothelium (UPII-NGFv2) will be used to determine the role that NGF plays in mediating functional, neurochemical and ..
  4. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
    ..p53 alterations are involved in the transformation of normal urothelium to carcinoma-in-situ of the bladder and in the progression to invasive disease...
  5. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2007
    ..by neurotrophic factors released within the bladder, (4) Bidirectional chemical communication between the urothelium and adjacent nerves plays a role in sensory mechanisms as well as in epithelial cell function in the urinary ..
  6. Glycosaminoglycans For IC Pathophysiology and Prognosis
    Vinata Lokeshwar; Fiscal Year: 2005
    ..Since the luminal glycosaminoglycan (GAG) layer protects the bladder urothelium from noxious substances in urine, alterations in urothelial GAGs may be associated with IC pathophysiology...
  7. Regulaton of Urothelial Growth
    Tung Tien Sun; Fiscal Year: 2007
    ..and proximal urethra is lined by a cell type described in standard textbooks as the transitional epithelium or urothelium, which is characterized by a highly specialized apical cell surface covered by rigid-looking urothelial plaques ..
  8. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2007
    ..Examine impact of aging on the ability of the urothelium to function as a regulatory interface between physical, inflammatory and endocrine stimuli involved in muscle ..
  9. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2009
    ..Examine impact of aging on the ability of the urothelium to function as a regulatory interface between physical, inflammatory and endocrine stimuli involved in muscle ..
  10. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George A Kuchel; Fiscal Year: 2010
    ..Examine impact of aging on the ability of the urothelium to function as a regulatory interface between physical, inflammatory and endocrine stimuli involved in muscle ..
  11. MVAC IN BLADDER CANCER BASED ON P53 STATUS
    Richard Cote; Fiscal Year: 1999
    ..p53 alterations/mutations have been shown to be involved in the transformation of normal urothelium to carcinoma in situ of the bladder and in the progression to invasive disease...
  12. Mouse Models for Interstitial Cystitis
    Edward Schwarz; Fiscal Year: 2004
    ..We will induce chronic cystitis by continuous exposure of the urothelium to agents that disrupt the bladder lining by implanting indwelling bladder catheter in each mouse...
  13. Role of Gene Expression in Interstitial Cystitis
    CHARLES BUFFINGTON; Fiscal Year: 2007
    ..The specific objectives of this proposal are to: 1) investigate the differential expression of genes in urothelium and adrenal cortex between normal cats and cats with FIC using a general screening strategy called rapid ..
  14. Bladder Cancer and Urinary Schistosomiasis in Ghana
    Clive Shiff; Fiscal Year: 2004
    ..is a persistent infection of young people that becomes chronic as they age, providing a nidus in the urothelium, which may attract bacteria, viruses and other inflammation stimulants...
  15. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..Recent pathologic studies have shown that patient symptoms are correlated with lesions of the urothelium that lines the bladder and accumulation of mast cells in the underlying lamina propria...
  16. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..Recent pathologic studies have shown that patient symptoms are correlated with lesions of the urothelium that lines the bladder and accumulation of mast cells in the underlying lamina propria...
  17. ROLE OF ISCHEMIA IN BLADDER OVERACTIVITY AND FIBROSIS
    MIKE SIROKY; Fiscal Year: 2003
    ..changes including bladder overactivity, abnormal smooth muscle reactivity, non-compliance, disruption of urothelium and fibrosis...
  18. Bacterial Survival in the Mammalian Urothelium
    JOSEPH PALERMO; Fiscal Year: 2007
    ..We will use co-infection of UPEC and K-12 bacteria to determine how UPEC alter the urothelium to improve bacterial survival...
  19. TRANSGENIC MOUSE MODELS FOR STUDYING PROSTATE/GU DISEASE
    Jeffrey Gordon; Fiscal Year: 2002
    ..The second component focuses on the urothelium. The undamaged adult mouse urothelium undergoes very slow turnover, making it difficult to identify the ..
  20. A COMPARISON OF IN VIVO AND VITRO TISSUE ENGINEERING
    Bradley Kropp; Fiscal Year: 2004
    ..In the urinary tract, SIS induces regeneration of bladder that contains all three layers of the bladder (urothelium, smooth muscle and serosa), has contractile activity, and is innervated...
  21. Genes Inducing Bladder Smooth Muscle Formation
    Laurence Baskin; Fiscal Year: 2010
    ..The key question is what are the signals or gene products from the urothelium that control bladder smooth muscle formation...
  22. Genes Inducing Bladder Smooth Muscle Formation
    Laurence Baskin; Fiscal Year: 2007
    ..The key question is what are the signals or gene products from the urothelium that control bladder smooth muscle formation...
  23. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2010
    ..explores the role of integrins and integrin-signaling pathways within the epithelium lining the bladder - the urothelium - where almost nothing is known of their function...
  24. Video Rate Optical Coherence Tomography for Early Stage Cancer Visualization
    Paul Amazeen; Fiscal Year: 2007
    ..Currently up to 6 random biopsies of normal appearing urothelium are taken in patients presenting with superficial bladder cancer at the time of the resection or biopsy of the ..
  25. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium. During bladder inflammation, MIF production is upregulated in the bladder and MIF is released into the intraluminal space where it ..