urothelium

Summary

Summary: The epithelial lining of the URINARY TRACT.

Top Publications

  1. ncbi Focus on bladder cancer
    Colin P N Dinney
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX USA
    Cancer Cell 6:111-6. 2004
  2. pmc Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
    Kunyoo Shin
    Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 472:110-4. 2011
  3. pmc Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux
    P Hu
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology, New York, New York 10016, USA
    J Cell Biol 151:961-72. 2000
  4. ncbi Urothelial tumorigenesis: a tale of divergent pathways
    Xue ru Wu
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Cancer 5:713-25. 2005
  5. pmc Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
    Erika M Wolff
    Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Res 70:8169-78. 2010
  6. pmc Uroplakin gene expression by normal and neoplastic human urothelium
    E D Lobban
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds, United Kingdom
    Am J Pathol 153:1957-67. 1998
  7. ncbi Intracellular bacterial biofilm-like pods in urinary tract infections
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 301:105-7. 2003
  8. ncbi Non-neuronal cholinergic system in human bladder urothelium
    Masaki Yoshida
    Department of Urology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Urology 67:425-30. 2006
  9. ncbi A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder
    S Roperto
    Department of Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:95-108. 2010
  10. pmc An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor
    Jayoung Kim
    Urological Diseases Research Center, Children s Hospital Boston, Boston, MA 02115, USA
    In Vitro Cell Dev Biol Anim 47:2-9. 2011

Detail Information

Publications291 found, 100 shown here

  1. ncbi Focus on bladder cancer
    Colin P N Dinney
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX USA
    Cancer Cell 6:111-6. 2004
  2. pmc Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
    Kunyoo Shin
    Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 472:110-4. 2011
    ..infection or chemical injury within the bladder is regulated by signal feedback between basal cells of the urothelium and the stromal cells that underlie them...
  3. pmc Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux
    P Hu
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology, New York, New York 10016, USA
    J Cell Biol 151:961-72. 2000
    b>Urothelium synthesizes a group of integral membrane proteins called uroplakins, which form two-dimensional crystals (urothelial plaques) covering >90% of the apical urothelial surface...
  4. ncbi Urothelial tumorigenesis: a tale of divergent pathways
    Xue ru Wu
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Cancer 5:713-25. 2005
    ..Correcting pathway-specific defects represents an attractive strategy for the molecular therapy of urothelial carcinomas...
  5. pmc Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
    Erika M Wolff
    Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Res 70:8169-78. 2010
    ..patterns between noninvasive and invasive UC and the DNA methylation patterns between normal-appearing urothelium from bladders with cancer and urothelium from cancer-free bladders...
  6. pmc Uroplakin gene expression by normal and neoplastic human urothelium
    E D Lobban
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds, United Kingdom
    Am J Pathol 153:1957-67. 1998
    ..Normal urothelium expressed mRNA for all four uroplakins, although UPIII could be detected only by ribonuclease protection assay...
  7. ncbi Intracellular bacterial biofilm-like pods in urinary tract infections
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 301:105-7. 2003
    ..The discovery of intracellular biofilm-like pods explains how bladder infections can persist in the face of robust host defenses...
  8. ncbi Non-neuronal cholinergic system in human bladder urothelium
    Masaki Yoshida
    Department of Urology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Urology 67:425-30. 2006
    ..To evaluate the non-neuronal cholinergic system in the isolated human bladder. Recently, several reports have demonstrated that non-nerve-evoked acetylcholine (ACh) release may contribute to various pathophysiologic conditions...
  9. ncbi A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder
    S Roperto
    Department of Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:95-108. 2010
    ..High-grade carcinomas, and low and high-grade invasive tumours, are less commonly seen. Bovine papillomavirus (BPV) infection and ingestion of bracken fern both play a central role in carcinogenesis of these lesions...
  10. pmc An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor
    Jayoung Kim
    Urological Diseases Research Center, Children s Hospital Boston, Boston, MA 02115, USA
    In Vitro Cell Dev Biol Anim 47:2-9. 2011
    Studies of the urothelium, the specialized epithelial lining of the urinary bladder, are critical for understanding diseases affecting the lower urinary tract, including interstitial cystitis, urinary tract infections and cancer...
  11. pmc Uroplakins in urothelial biology, function, and disease
    Xue ru Wu
    Department of Urology, New York University Langone Medical Center, New York, USA
    Kidney Int 75:1153-65. 2009
    b>Urothelium covers the inner surfaces of the renal pelvis, ureter, bladder, and prostatic urethra...
  12. ncbi P2X3 knock-out mice reveal a major sensory role for urothelially released ATP
    M Vlaskovska
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    J Neurosci 21:5670-7. 2001
    ..These data strongly suggest a major sensory role for urothelially released ATP acting via P2X(3) receptors on a subpopulation of pelvic afferent fibers...
  13. ncbi Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
    Peter J Goebell
    Department of Urology, University Clinic of Erlangen, Erlangen, Germany
    Urol Oncol 28:409-28. 2010
    ..The molecular pathogenesis of high-grade noninvasive papillary tumors and of T1 tumors is not yet clear, and possibilities are discussed...
  14. pmc Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT)
    Li Mei Chen
    Department of Molecular Biology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida 32816, USA
    BMC Cancer 9:377. 2009
    ..The aim of this study was to evaluate prostasin expression states in the transitional cell carcinomas (TCC) of the human bladder and in human TCC cell lines...
  15. pmc The immortalized UROtsa cell line as a potential cell culture model of human urothelium
    M R Rossi
    Genetics and Developmental Biology Program, West Virginia University, Morgantown, West Virginia, USA
    Environ Health Perspect 109:801-8. 2001
    The UROtsa cell line was isolated from a primary culture of normal human urothelium through immortalization with a construct containing the SV40 large T antigen...
  16. pmc Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle
    Sante Roperto
    Department of Pathology and Animal Health, Division of Infectious Diseases, Naples University Federico II, Naples, Italy
    PLoS ONE 5:e10299. 2010
    ..So far the link between calpain3 and tumors comes from in vitro studies. The objective of this study was to describe Capn3 activation in naturally occurring urothelial tumors of the urinary bladder in cattle...
  17. pmc Bacteria-induced uroplakin signaling mediates bladder response to infection
    Praveen Thumbikat
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    PLoS Pathog 5:e1000415. 2009
    ..Our studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli...
  18. ncbi Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis
    Yan Sun
    Division of Urology, Dept of Surgery, Univ of Maryland School of Medicine, 22 S Greene St, S8D18, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 290:C27-34. 2006
    ..In conclusion, IC BUCs have augmented extracellular ATP signaling that could be blocked by suramin and HB-EGF. These findings suggest the possible development of future novel therapeutic techniques...
  19. pmc Cell biology and physiology of the uroepithelium
    Puneet Khandelwal
    Univ of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 297:F1477-501. 2009
    ..Finally, we describe potential mechanisms by which the uroepithelium can transmit information about the urinary space to the other tissues in the bladder proper...
  20. ncbi Gemcitabine plus cisplatin versus gemcitabine plus carboplatin as first-line chemotherapy in advanced transitional cell carcinoma of the urothelium: results of a randomized phase 2 trial
    Luigi Dogliotti
    Unit of Medical Oncology, University of Torino, San Luigi Hospital, Orbassano Torino, Italy
    Eur Urol 52:134-41. 2007
    ..of gemcitabine-cisplatin (GP) and gemcitabine-carboplatin (GC) in patients with advanced transitional cell carcinoma of the urothelium (TCC), with the main objective to demonstrate a reduction in toxicity of at least 25% in the GC arm.
  21. ncbi Enhanced adenosine triphosphate release from the urothelium of patients with painful bladder syndrome: a possible pathophysiological explanation
    Vivek Kumar
    Department of Urology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Urol 178:1533-6. 2007
    We established the level of adenosine triphosphate release by the urothelium in patients with painful bladder syndrome and compared it with that from the normal human bladder.
  22. pmc Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium
    Bikramjit Chopra
    A1207 Scaife Hall, Department of Medicine Renal Division, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Physiol 562:859-71. 2005
    The bladder urothelium exhibits dynamic sensory properties that adapt to changes in the local environment...
  23. ncbi Everything you wanted to know about the bladder epithelium but were afraid to ask
    S A Lewis
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555 0641, USA
    Am J Physiol Renal Physiol 278:F867-74. 2000
    The mammalian urinary bladder epithelium (urothelium) performs the important function of storing urine for extended periods, while maintaining the urine composition similar to that delivered by the kidneys...
  24. pmc Differentiation of a highly tumorigenic basal cell compartment in urothelial carcinoma
    Xiaobing He
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland USA
    Stem Cells 27:1487-95. 2009
    ..The spatially restricted epithelial differentiation program described here represents a conceptual advance in understanding cellular heterogeneity of carcinomas and identifies basal-like HTCs as attractive targets for cancer therapy...
  25. ncbi Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium
    L A Birder
    Dept of Medicine, Laboratory of Epithelial Cell Biology, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Physiol Renal Physiol 285:F423-9. 2003
    ..IP3) receptors (thapsigargin, acetylcholine) release significantly more ATP in FIC compared with normal urothelium. Taken together, these results suggest that FIC results in a novel hypersensitivity to mechanical stimuli that ..
  26. ncbi Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium
    Shirin Zarghooni
    Institute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Life Sci 80:2308-13. 2007
    ..of muscarinic receptor subtypes (MR) and nicotinic acetylcholine receptor (nAChR) alpha-subunits in the mouse urothelium by RT-PCR and immunohistochemistry...
  27. ncbi The uroepithelium: not just a passive barrier
    Gerard Apodaca
    Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Traffic 5:117-28. 2004
    ....
  28. ncbi A refocus on the bladder as the originator of storage lower urinary tract symptoms: a systematic review of the latest literature
    Alexander Roosen
    Department of Urology, Ludwig Maximilians University, Munich, Germany
    Eur Urol 56:810-9. 2009
    ..This is mirrored by an increasing body of experimental evidence suggesting that the bladder is the central organ in the pathogenesis of LUTS...
  29. ncbi Trajectorial organisation of cytokeratins within the subapical region of umbrella cells
    Peter Veranic
    Institute of Cell Biology, Medical Faculty of Ljubljana, Slovenia
    Cell Motil Cytoskeleton 53:317-25. 2002
    ..Discovery of the subapical CK network elucidates the until now undescribed supramolecular organisation of CKs in the apical region of urothelial cells...
  30. pmc Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics
    Matthew G Blango
    Pathology Department, Division of Cell Biology and Immunology, University of Utah, Salt Lake City, UT 84112 0565, USA
    Antimicrob Agents Chemother 54:1855-63. 2010
    ..treatments, is likely facilitated by a combination of biofilm formation, entry of UPEC into a quiescent or semiquiescent state within host cells, and the stalwart permeability barrier function associated with the bladder urothelium.
  31. pmc An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer
    Shizhang Ling
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 71:3812-21. 2011
    ..in invasive human UroCa tissue samples (n = 84) compared with noninvasive cancers (n = 56) or benign adjacent urothelium (n = 49)...
  32. ncbi Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder
    Hiroshi Miyamoto
    Department of Pathology Urology, University of Rochester Medical Center, Rochester, NY, USA
    BJU Int 109:1716-26. 2012
    ..Our data demonstrate that the expression status correlates with tumour grades/stages and patients' outcomes...
  33. pmc Urothelial function reconsidered: a role in urinary protein secretion
    F M Deng
    The Ronald Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University Medical School, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:154-9. 2001
    ..Our data indicate that normal bovine urothelium synthesizes, as its major differentiation products, two well-known proteases: tissue-type plasminogen activator ..
  34. pmc Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine
    Pi che Chen
    Department of Life Science, National Chung Cheng University, Min Hsiung, Chia Yi, Taiwan
    BMC Med Genomics 4:45. 2011
    ..Previous studies have identified several tumor-related genes that are hypermethylated in bladder cancer; however the DNA methylation profile of bladder cancer in Taiwan is not fully understood...
  35. ncbi Bovine papillomavirus type 2 infects the urinary bladder of water buffalo (Bubalus bubalis) and plays a crucial role in bubaline urothelial carcinogenesis
    Sante Roperto
    Dipartimento di Patologia e Sanita Animale, Sezione Malattie Infettive, Facolta di Medicina Veterinaria, Universita di Napoli Federico II, Napoli, Italy
    J Gen Virol 94:403-8. 2013
    ..Our results indicate that the E5-PDGF β receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes...
  36. ncbi Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium
    Prasad Acharya
    Renal Electrolyte Division, Department of Medicine, Laboratory of Epithelial Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 287:F305-18. 2004
    ....
  37. ncbi Fibroblast growth factors and their receptors in transitional cell carcinoma
    Nicholas P Munro
    Cancer Research United Kingdom Clinical Centre in Leeds, St James s University Hospital, Leeds, United Kingdom
    J Urol 169:675-82. 2003
    ..We examined these possibilities in light of the published literature...
  38. ncbi Bladder permeability barrier: recovery from selective injury of surface epithelial cells
    John Lavelle
    Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Renal Physiol 283:F242-53. 2002
    ..To perform this function, the urothelium maintains a tight permeability barrier...
  39. pmc All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms
    Joshua R Mauney
    Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts, USA
    PLoS ONE 5:e11513. 2010
    The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that acts as a specialized permeability barrier that protects the underlying tissue from urine via expression of a highly specific group of ..
  40. ncbi Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro
    Peter C Rubenwolf
    Jack Birch Unit for Molecular Carcinogenesis, Department of Biology, University of York, York, UK
    Eur Urol 56:1013-23. 2009
    b>Urothelium is generally considered to be impermeable to water and constituents of urine...
  41. pmc Differentiation of human bone marrow mesenchymal stem cells into bladder cells: potential for urological tissue engineering
    Hong Tian
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Tissue Eng Part A 16:1769-79. 2010
    ..Simultaneous differentiation of human BMSCs into smooth muscle cells (SMCs) and urothelium would be beneficial for clinical applications in bladder regeneration for patients with bladder exstrophy or ..
  42. ncbi P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis
    H V Tempest
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    BJU Int 93:1344-8. 2004
    ..the expression of P2X(3) receptors (implicated in the pathophysiology of pain) is altered in human bladder urothelium from patients with interstitial cystitis (IC, a major symptom of which is pain), and as P2X(2) receptors can be ..
  43. ncbi Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells
    Ana Charrua
    Institute of Histology and Embryology, Instituto de Ciencias Biomedicas Abel Salazar, University of Porto, Porto, Portugal
    J Urol 182:2944-50. 2009
    ..We investigated the expression and functional status of TRPV1 receptor in human urothelial cells...
  44. ncbi Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    Shugo Suzuki
    Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Toxicol Sci 113:349-57. 2010
    ..This strongly supports the previous conclusion in studies with muraglitazar that this is a rat-specific phenomenon and does not pose a urinary bladder cancer risk to humans treated with these agents...
  45. ncbi Golgi apparatus fragmentation as a mechanism responsible for uniform delivery of uroplakins to the apical plasma membrane of uroepithelial cells
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    Biol Cell 102:593-607. 2010
    ..We have used the culture model of UCs with the capacity to undergo terminal differentiation to study the process of uniform delivery of DFVs to the APM and to elucidate the mechanisms involved...
  46. ncbi Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation
    Z T Zhang
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 20:1973-80. 2001
    ..Using a urothelium-specific promoter of the uroplakin II gene, we showed earlier in transgenic mice that the urothelial expression ..
  47. ncbi No evidence for involvement of beta-catenin and APC in urothelial carcinomas
    Robert Stoehr
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Int J Oncol 20:905-11. 2002
    ..Other wnt pathway members, such as axin, may play an important role in urothelial carcinogenesis...
  48. ncbi Urothelial carcinomas arising in arsenic-contaminated areas are associated with hypermethylation of the gene promoter of the death-associated protein kinase
    W T Chen
    Department of Pathology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Histopathology 51:785-92. 2007
    ..The aim was to determine whether hypermethylation of death-associated protein kinase (DAPK) gene is associated with chronic arsenic exposure...
  49. pmc Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function
    Birthe Schnegelsberg
    Department of Neuroscience, Roche Palo Alto, Palo Alto, California, USA
    Am J Physiol Regul Integr Comp Physiol 298:R534-47. 2010
    ..sensory function, we generated a transgenic mouse model of chronic NGF overexpression in the bladder using the urothelium-specific uroplakin II (UPII) promoter...
  50. pmc Differentiation potential of urothelium from patients with benign bladder dysfunction
    Jennifer Southgate
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York, UK
    BJU Int 99:1506-16. 2007
    ....
  51. ncbi What determines differentiation of urothelial umbrella cells?
    Peter Veranic
    Institute of Cell Biology, Medical Faculty, Ljubljana, Slovenia
    Eur J Cell Biol 83:27-34. 2004
    ..differentiation markers, cytokeratins and uroplakins, during differentiation of umbrella cells of mouse bladder urothelium. Regenerating urothelium after destruction with cyclophosphamide was used to simulate de-novo differentiation of ..
  52. pmc Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases
    Xiang Tian Kong
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 167:1195-204. 2004
    The apical surface of mouse urothelium is covered by two-dimensional crystals (plaques) of uroplakin (UP) particles. To study uroplakin function, we ablated the mouse UPII gene...
  53. ncbi Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression
    Anita Sabichi
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 175:1133-7. 2006
    ..Cell lines have become an essential component for the investigation of cancer. We have developed a panel of cell lines derived from human urothelial cancers and we describe some of their important characteristics...
  54. ncbi Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines
    Darren C Tomlinson
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, United Kingdom
    Cancer Res 65:10441-9. 2005
    ..FGFR3 was identified as the major family member expressed in both normal human urothelium and cultured normal human urothelial (NHU) cells and was expressed as the IIIb isoform...
  55. ncbi Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients
    Hiroshi Tsuruta
    Department of Urology, Akita University School of Medicine, Akita, Japan
    Cancer Res 66:8389-96. 2006
    PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate an urothelium-specific null mutation of Pten in mice [FabpCrePten(flox/flox) (FPten(flox/flox)) mice]...
  56. ncbi Characterization of the purinergic receptor subtype on guinea-pig suburothelial myofibroblasts
    Gui Ping Sui
    Institute of Urology, University College London, London, UK
    BJU Int 97:1327-31. 2006
    ....
  57. ncbi The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis
    Grannum R Sant
    Department of Urology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Urology 69:34-40. 2007
    ....
  58. ncbi Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer
    Fiona M Platt
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, United Kingdom
    Clin Cancer Res 15:6008-17. 2009
    ..Our aim was to assess the frequency and distribution of pathway alterations in bladder cancer...
  59. pmc Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking
    Chih Chi Andrew Hu
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Mol Biol Cell 16:3937-50. 2005
    The apical surface of mammalian urothelium is covered by 16-nm protein particles packed hexagonally to form 2D crystals of asymmetric unit membranes (AUM) that contribute to the remarkable permeability barrier function of the urinary ..
  60. ncbi Behavior of urothelial carcinoma with respect to anatomical location
    J W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 177:1715-20. 2007
    Urothelial carcinoma is a disease of the entire urothelium. Recent molecular insights suggest that the biology of some upper urinary tract and bladder urothelial carcinoma differ. These differences may affect tumor phenotype...
  61. pmc Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells
    Emma J Chapman
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds LS97TF, United Kingdom
    Mol Cancer Res 6:1154-68. 2008
    ..Our data supports the concept of both telomere-based and non-telomere effects of telomerase and provides further rationale for the use of telomerase inhibitors in UC...
  62. ncbi Botulinum toxin A inhibits ATP release from bladder urothelium after chronic spinal cord injury
    Mohit Khera
    Scott Department of Urology, Baylor College of Medicine, One Baylor Plaza, Alkek Building N720, Houston, TX 77030, USA
    Neurochem Int 45:987-93. 2004
    ..examined to demonstrate if spinal cord injury (SCI) modulates the basal or evoked release of ATP from bladder urothelium and whether intravesical botulinum toxin A (BTX-A) administration inhibits urothelial ATP release, a measure of ..
  63. ncbi Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability
    Ping Hu
    Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, NY 10016, USA
    Am J Physiol Renal Physiol 283:F1200-7. 2002
    ..J Cell Biol 151: 961-972, 2000). Our results indicate that normal mouse urothelium exhibits high transepithelial resistance and low urea and water permeabilities...
  64. pmc ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells
    Edward C Y Wang
    Renal Electrolyte Division and Laboratory of Epithelial Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 115:2412-22. 2005
    ....
  65. ncbi Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: effect of botulinum toxin A
    Christopher P Smith
    Scott Department of Urology, Baylor College of Medicine, One Baylor Plaza, Alkek N720, Houston, TX 77030, USA
    Neurochem Int 47:291-7. 2005
    ..bladder inflammation was examined to demonstrate: (1) whether inflammation modulates ATP release from bladder urothelium and (2) whether intravesical botulinum toxin A administration inhibits urothelial ATP release, a measure of ..
  66. pmc Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer
    Philip Levy Ho
    Department of Urology, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 72:3135-42. 2012
    ..Together, our findings show that Stat3-induced stem cell expansion plays a critical role in the unique clinical progression of invasive bladder cancer through the CIS pathway...
  67. pmc Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli
    Danelle S Eto
    Division of Cell Biology and Immunology, Pathology Department, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Pathog 3:e100. 2007
    ..FimH recognizes N-linked oligosaccharides on these receptors, which are expressed throughout the urothelium. In a bladder cell culture system, beta1 and alpha3 integrin receptors co-localize with invading type 1-piliated ..
  68. ncbi The role of beta-catenin signaling in the malignant potential of cystitis glandularis
    R T Bryan
    Epithelial Laboratory, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    J Urol 170:1892-6. 2003
    ..Cystitis glandularis is a metaplastic lesion of the bladder urothelium occurring in the presence of chronic inflammation and in up to 13% of asymptomatic bladders...
  69. ncbi The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis
    C Lowell Parsons
    Division of Urology, Department of Surgery, University of California, San Diego Medical Center, University of California, San Diego, San Diego, California 92103 8897, USA
    Urology 69:9-16. 2007
    The urothelium plays a pivotal role as a barrier between urine and its solutes and the underlying bladder. Bladder surface mucus is a critical component of this function...
  70. pmc Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement
    Feng Xia Liang
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology
    J Cell Biol 171:835-44. 2005
    Although the epithelial lining of much of the mammalian urinary tract is known simply as the urothelium, this epithelium can be divided into at least three lineages of renal pelvis/ureter, bladder/trigone, and proximal urethra based on ..
  71. ncbi Immunohistochemical detection of apoptosis, proliferation and inducible nitric oxide synthase in rat urothelium damaged by cyclophosphamide treatment
    Kristijan Jezernik
    Institute of Cell Biology, Medical Faculty, Lipiceva 2, 1000 Ljubljana, Slovenia
    Cell Biol Int 27:863-9. 2003
    ..to investigate cell death, proliferation and inducible nitric oxide synthase (iNOS) immunoreactivity in rat urothelium within 24 h after a single intraperitoneal dose of cyclophosphamide (CP)...
  72. ncbi Scaffold seeded with cells is essential in urothelium regeneration and tissue remodeling in vivo after bladder augmentation using in vitro engineered graft
    T Drewa
    The Laboratory for Tissue Engineering, Medical Biology Department, N Copernicus University, ul Karlowicza 24, 85 092 Bydgoszcz, Torun, Poland
    Transplant Proc 38:133-5. 2006
    ..The aim of the study was to induce in vivo urothelial growth on implanted scaffolds previously seeded with stromal cells as compared with matrices implanted without cells for rat cystoplasty augmentation...
  73. pmc Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model
    C Escudero-Lourdes
    Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, San Luis Potosi, SLP 78240, Mexico
    Toxicol Appl Pharmacol 244:162-73. 2010
    ..Taken together these results support the notion that chronic inflammation is associated within MMA(III)-induced cell transformation and may act as a promoting factor in UROtsa cell transformation...
  74. pmc A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer
    Jialou Zhu
    Beijing Genomics Institute at Shenzhen, Shenzhen, China
    PLoS ONE 6:e28223. 2011
    ..DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers. A systematic study of methylome and transcriptome in bladder urothelial carcinoma has never been reported...
  75. pmc Identification of genes correlated with early-stage bladder cancer progression
    Randolph Stone
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center Shreveport and Feist Weiller Cancer Center, USA
    Cancer Prev Res (Phila) 3:776-86. 2010
    ..expressed (> or =3-fold difference at one or more time points) between wild-type and UPII-SV40Tag urothelium during the time course of tumor development...
  76. ncbi Immortalisation of normal human urothelial cells compromises differentiation capacity
    Nikolaos T Georgopoulos
    Jack Birch Unit for Molecular Carcinogenesis, Department of Biology, University of York, York, UK
    Eur Urol 60:141-9. 2011
    ..Although tumour grade is an independent prognostic marker for urothelial carcinoma (UC), the molecular events underpinning the loss of urothelial differentiation are poorly understood...
  77. ncbi Invasive micropapillary urothelial carcinoma of the bladder
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Department of Surgery, University of Cordoba Faculty of Medicine, E 14004, Cordoba, Spain
    Hum Pathol 41:1159-64. 2010
    ..The morphologic diversity of micropapillary carcinoma may represent a diagnostic pitfall in limited samples, where its distinction from conventional urothelial carcinoma is critical for its clinical management...
  78. ncbi Expression and clinical significance of hepaCAM and VEGF in urothelial carcinoma
    Shuzhe Yang
    Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China
    World J Urol 28:473-8. 2010
    ....
  79. pmc Defining protein expression in the urothelium: a problem of more than transitional interest
    Weiqun Yu
    Laboratory of Voiding Dysfunction, Division of Renal Research, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Renal Physiol 301:F932-42. 2011
    The transitional epithelium of the bladder, the urothelium, is a challenging tissue to study due to its fragility, complex cellular makeup, stratified composition, and intimate connections to both neural and connective tissue elements...
  80. ncbi Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo
    Ting Tsz Ou
    Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Ethnopharmacol 135:162-72. 2011
    ..Extracts of Paeonia lactiflora Pall (RPA), a traditional Chinese medicines has been shown to treat cancers...
  81. ncbi Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis
    Emmanuel Graham
    Division of Urology, University of Maryland Medical Center, 22 S Greene Street, S8D18, Baltimore, MD 21201, USA
    Curr Urol Rep 7:440-6. 2006
    The human bladder urothelium (BU) and bladder urothelial cells (BUCs) play an important role in the normal functioning of bladder including bladder storage...
  82. ncbi Immunohistochemical expression of muscarinic receptors in the urothelium and suburothelium of neurogenic and idiopathic overactive human bladders, and changes with botulinum neurotoxin administration
    Soumendra N Datta
    Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United Kingdom
    J Urol 184:2578-85. 2010
    ..we examined the immunohistochemical expression of muscarinic receptors types 1, 2 and 3 in the bladder urothelium and suburothelium of patients with neurogenic or idiopathic detrusor overactivity compared with that in controls...
  83. ncbi Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Clin Cancer Res 16:5654-63. 2010
    ..Foxo3a is a member of the Foxo transcription factor family that modulates the expression of various genes. We aimed to elucidate the role of Foxo3a in UC invasion...
  84. ncbi The human urothelium consists of multiple clonal units, each maintained by a stem cell
    Nadine T Gaisa
    Institute of Pathology RWTH Aachen University, Aachen, Germany
    J Pathol 225:163-71. 2011
    Little is known about the clonal architecture of human urothelium. It is likely that urothelial stem cells reside within the basal epithelial layer, yet lineage tracing from a single stem cell as a means to show the presence of a ..
  85. ncbi Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway
    E J Chapman
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Oncogene 25:5037-45. 2006
    ..The production of genetically normal but immortal NHUC lines now provides a valuable platform for experiments to examine the timing and combination of events necessary for UCC tumorigenesis...
  86. ncbi The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
    Milan Chromek
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nat Med 12:636-41. 2006
    ..In addition, clinical E. coli strains that were more resistant to LL-37 caused more severe urinary tract infections than did susceptible strains. Thus, cathelicidin seems to be a key factor in mucosal immunity of the urinary tract...
  87. ncbi The WHO classification of 1973 is more suitable than the WHO classification of 2004 for predicting survival in pT1 urothelial bladder cancer
    Wolfgang Otto
    Department of Urology, University of Regensburg, Regensburg, Erlangen, Germany
    BJU Int 107:404-8. 2011
    ..To ascertain which of the currently defined World Health Organization (WHO) grading classifications of pT1 urothelial bladder cancer (BC), published in 1973 and 2004, is more suitable for predicting outcome...
  88. ncbi Efficacy of a broad host range lytic bacteriophage against E. coli adhered to urothelium
    Sanna Sillankorva
    Department of Biological Engineering, University of Minho, Braga, Portugal
    Curr Microbiol 62:1128-32. 2011
    Persistent urinary tract infections (UTI) are often caused by E. coli adhered to urothelium. This type of cells is generally recognized as very tolerant to antibiotics which renders difficult the treatment of chronic UTI...
  89. ncbi Impact of gender on bladder cancer incidence, staging, and prognosis
    Harun Fajkovic
    Department of Urology and Division of Medical Oncology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA
    World J Urol 29:457-63. 2011
    ..Our aim was to review the literature on the effect of gender on bladder cancer incidence, biology, mortality, and treatment...
  90. pmc Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium
    Sheila M Bell
    Perinatal Institute of Cincinnati Children s Hospital Medical Center, Division of Neonatology Perinatal Pulmonary Biology, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 358:79-90. 2011
    Kruppel-like transcription factor 5 (Klf5) was detected in the developing and mature murine bladder urothelium. Herein we report a critical role of KLF5 in the formation and terminal differentiation of the urothelium...
  91. ncbi High urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissues
    David A Spector
    Division of Renal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 292:F467-74. 2007
    ..are consistent with the notion that urea and creatinine are continuously reabsorbed from the urine across the urothelium, urea in part via UT-B, and that urine is thus altered in its passage through the urinary tract...
  92. pmc Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome
    Hong Ying Huang
    Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Hum Pathol 38:1703-13. 2007
    As the terminal differentiation products of human urothelium, uroplakins (UPs) would be expected to diminish during urothelial tumorigenesis...
  93. pmc Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner
    E Di Martino
    Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Oncogene 28:4306-16. 2009
    ..Our results indicate that the effects of mutant FGFR3 are both cell type specific and mutation specific. Mutant FGFR3 may confer a selective advantage in the urothelium by overcoming normal contact inhibition of proliferation.
  94. ncbi Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas
    Gamze Donmez
    Adana Numune Education and Research Hospital, Department of Pathology, Adana, Turkey
    Pathol Res Pract 205:854-7. 2009
    ..014, r=-0.21). Increased VEGF and MMP-9 expression as well as decreased TSP-1 expression may play considerable roles in the invasion and differentiation of urothelial carcinoma...
  95. ncbi The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack
    J W M Yuen
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
    J Ethnopharmacol 118:324-30. 2008
    ..The effects of Lingzhi antioxidants on oxidative DNA damage and oxidative stress were investigated, in order to understand their roles in bladder chemoprevention...
  96. pmc Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
    Joel D Schilling
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:4203-8. 2003
    ..These results demonstrated that bladder epithelial cells play a critical role in TLR4-mediated innate immunity in vivo during a mucosal bacterial infection...
  97. ncbi Hyperplasia as a mechanism for rapid resealing urothelial injuries and maintaining high transepithelial resistance
    Tanja Višnjar
    Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia
    Histochem Cell Biol 137:177-86. 2012
    ....
  98. pmc Urinary bladder smooth muscle engineered from adipose stem cells and a three dimensional synthetic composite
    Gregory S Jack
    Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States
    Biomaterials 30:3259-70. 2009
    ..Our study demonstrates the feasibility and short term physical properties of bladder tissue engineered from adipose stem cells...
  99. ncbi Molecular pathogenesis and diagnostics of bladder cancer
    Anirban P Mitra
    Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Annu Rev Pathol 4:251-85. 2009
    ..The future of bladder cancer patient management will rely on the use of molecular tests to reliably diagnose the presence of disease, predict individual tumor behavior, and suggest potential targeted therapeutics...
  100. ncbi Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma
    Ute Gabriel
    Department of Urology, Mannheim Medical Center, University of Heidelberg, 68167 Mannheim, Germany
    Oncol Rep 20:1419-23. 2008
    ..conclusion, bcl-2 AS-ODNs show significantly higher cell mortality in TCC cells, whereas toxic effects on normal urothelium seem to be minor...
  101. ncbi The 2004 WHO classification of bladder tumors: a summary and commentary
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Int J Surg Pathol 13:143-53. 2005
    ..This scheme is meant to replace the 1973 WHO classification, but the use of both the 1973 and the latest WHO classifications is recommended until the latter is sufficiently validated...

Research Grants67

  1. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..The Inhibitor of Apoptosis (IAP), survivin, is not detected in normal urothelium and its expression in bladder cancer correlates with poor prognosis...
  2. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2013
    ..explores the role of integrins and integrin-signaling pathways within the epithelium lining the bladder - the urothelium - where almost nothing is known of their function...
  3. Optically-Guided Bladder Biopsy Using Polarized Elastic Scattering Spectroscopy
    FREDERICK GEORGE BARGOOT; Fiscal Year: 2010
    ..PESS spectral features and tissue histology for empirical classification of PESS spectra as indicative of normal urothelium, interstitial cystitis, low-grade bladder carcinoma, or high-grade bladder carcinoma...
  4. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2013
    ..We have identified a number of abnormalities in the urothelium of FIC bladders including alterations in barrier function, proliferation and growth, and a heightened ..
  5. Pharmacology of Intravesical Antisense Based Therapy for Over Active Bladder
    Naoki Yoshimura; Fiscal Year: 2013
    ..NGF antisense administered via different routes, we propose to investigate the contribution of NGF derived from urothelium on afferent hyperexcitability leading to DO in SCI animals...
  6. Cystitis-Induced Plasticity of Micturitin Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2013
    ..and pelvic hypersensitivity in a novel transgenic mouse model of chronic NGF overexpression (NGF-OE) using the urothelium-specific uroplakin II promoter that was characterized during the last funding cycle...
  7. Identification, Characterization and Enrichment of Adult Urothelial Stem Cells
    ERIC ABRAHAM KURZROCK; Fiscal Year: 2010
    ..Using known markers for stem cells in other systems, urothelium will be sorted into stem and non-stem cell populations...
  8. DLGH1 AND UROGENITAL DEVELOPMENT
    WOJCIECH A SWAT; Fiscal Year: 2012
    ..In addition, ureteric stromal cells, which normally lie between the urothelium and the smooth muscle layers and express Raldh2, are absent from Dlgh1 mutant ureters...
  9. Bacterial Survival in the Mammalian Urothelium
    JOSEPH PALERMO; Fiscal Year: 2010
    ..We will use co-infection of UPEC and K-12 bacteria to determine how UPEC alter the urothelium to improve bacterial survival...
  10. Role of Nitric Oxide in Feline Interstitial Cystitis.
    Lori Birder; Fiscal Year: 2009
    ..We have identified a number of abnormalities in the urothelium of FIC bladders including alterations in barrier function, proliferation and growth, and a heightened ..
  11. Rapid release paclitaxel nanoparticles for bladder cancer intravestical therapy
    Ze Lu; Fiscal Year: 2009
    ..a) it has activity against bladder cancer, (b) it is lipophilic and therefore can readily partition across the urothelium, (c) it binds to tissues and therefore is retained beyond the 2-hr duration of the intravesical therapy, and (d) ..
  12. Bladder drug delivery using intravesical liposomes to treat overactive bladder
    JONATHAN H KAUFMAN; Fiscal Year: 2012
    ..We hypothesize that adverse effects of BoNT can be drastically reduced by restricting its action only to urothelium and suburothelium space...
  13. Validation in Transgenic Animal Models of Clinical Correlates of IC/PBS
    Yi Luo; Fiscal Year: 2013
    ..The URO-MCP-1 model secretes monocyte chemotactic protein-1 (MCP-1) by the urothelium and mimics the hypersensitive bladders of IC/PBS patients...
  14. The role of the mitotic spindle protein RHAMM in early stage bladder cancer
    RANDOLPH STONE II; Fiscal Year: 2012
    ..Genes that were differentially expressed between the urothelium of UPII-SV40Tag mice and their age-matched wild type (non-transgenic) littermates at 3, 6, 20, and 30 weeks of ..
  15. Epithelial/stromal signaling in bladder and prostate cell proliferation
    Philip A Beachy; Fiscal Year: 2013
    ..infection, expression of the Sonic hedgehog (Shh) protein signal increases in a subset of basal cells of the urothelium, and this triggers a response in cells of the underlying stroma, including increased expression of Wnt and FGF ..
  16. Common Mechanisms of Stem Cell Regulation in Bladder Cancer and Regeneration
    Kunyoo Shin; Fiscal Year: 2013
    ..express the Sonic hedgehog (Shh) ligand in urinary bladder as urothelial stem cells, capable of regenerating the urothelium following injury in vivo and of forming bladder-like organoids from single cells in vitro...
  17. Generating molecular markers that selectively label urothelial sub-populations
    CATHY LEE MENDELSOHN; Fiscal Year: 2013
    ..the renal pelvis, ureters, bladder and upper urethra, is lined by a specialized stratified epithelium called the urothelium, composed of a basal layer, an intermediate layer and a superficial layer consisting of umbrella cells...
  18. Brain Bladder Interactions in IC/PBS
    LARISSA RODRIGUEZ; Fiscal Year: 2012
    ..model which aims at studying cellular and molecular consequences of altered noradrenergic/SNS signaling on the urothelium and spinal glial cells...
  19. Treatment of Bladder Pain by Novel Glycosaminoglycan Derivatives
    Siam Oottamasathien; Fiscal Year: 2013
    ..model, we've demonstrated LL-37 could elicit profound dose dependent bladder inflammation involving the urothelium. Furthermore, the propagation of inflammation involves mast cells in a dose dependent fashion...
  20. DE NOVO DNA METHYLATION IN BLADDER CANCER
    GANGNING NONE LIANG; Fiscal Year: 2013
    ..on the Illumina platform, we have observed a hypomethylation phenotype not seen in the apparently normal urothelium but particularly prevalent in superficial tumors and less frequently in more invasive tumors...
  21. Photo-assisted targeting of immunotherapy to the bladder
    DIMITRI SIMBERG; Fiscal Year: 2013
    ..At the Moores UCSD Cancer Center, we found peptides that efficiently penetrated the urothelium following local mechanical damage to the urothelium (similar to the damage following tumor removal)...
  22. Gene transfer to treat urinary urgency frequency nocturia &incontinence
    Moses Tar; Fiscal Year: 2012
    ..That promoter that will be compared in a variety of cell types (tissue cultured rat urothelium, rat bladder smooth muscle, and HEK cells) to cell type specific expression of hSlo from two other well ..
  23. BIOCHEMISTRY OF UROTHELIAL DIFFERENTIATION
    Tung Tien Sun; Fiscal Year: 2012
    ..Central to this paradigm is a group of urothelium-specific proteins, the uroplakins, that are made as major urothelial differentiation products...
  24. Evaluation of Stimulus-Evoked Membrane Trafficking in Bladder Urothelial Cells
    ANN THERESA HANNA-MITCHELL; Fiscal Year: 2013
    ..injury or inflammation results in augmented release of chemical- or stretch-evoked neurotransmitters from the urothelium. Alterations in urothelial-derived mediators could alter the activity of bladder nerves in close proximity to ..
  25. Nitric oxide in bladder neural-epithelial signaling
    Lori A Birder; Fiscal Year: 2013
    ..Mechanical forces are thought to "initiate" a series of signaling events (calcium waves) throughout the urothelium. In turn, the accompanying release of chemical factors induced by mechanical stimuli could activate urothelial ..
  26. The Role of Urothelial-Interstitial Cell Communication in Detrusor Overactivity
    Youko Ikeda; Fiscal Year: 2010
    ..However, the mechanism by which these signals are transduced from the urothelium to influence bladder activity and their specific targets is not entirely clear...
  27. BIOLOGY AND PATHOPHYSIOLOGY OF UROTHELIUM IN BLADDER DISEASE
    GERALD LOUIS ANDRIOLE; Fiscal Year: 2013
    ..to establish an Interdisciplinary Research Center in Benign Urology focused on "Biology and Pathophysiology of Urothelium in Bladder Disease...
  28. Spatial and Temporal Induction of Calcineurin in the Urinary Bladder
    STEPHEN ANTHONY ZDERIC; Fiscal Year: 2013
    ..that allows us to turn on calcineurin under the control of the doxycycline sensitive promoter within the urothelium or the smooth muscle cell populations...
  29. Application of Boolean Networks to discover stem and progenitor cells
    Debashis Sahoo; Fiscal Year: 2012
    ..More than 90% of human bladder cancers arise from a simple epithelial tissue called urothelium, and are commonly called transitional cell carcinomas (TCC)...
  30. Retinoic acid signaling controls urothelial development and regeneration
    CATHY LEE MENDELSOHN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The urothelium is a stratified epithelium composed of Krt5-expressing basal cells, intermediate cells, and a luminal layer of umbrella cells that provide a crucial barrier between the urinary tract ..
  31. Mouse Urinary Bladder Identifying Targets to Treat Overactive Bladder
    Eugene M Silinsky; Fiscal Year: 2013
    ..will define the role of these receptors as neuromodulators and measure the influence of epithelial components (urothelium/suburothelium) on neurotransmission and release...
  32. Program Project: Growth, Differentiation and Disease of Urothelium
    Tung Tien Sun; Fiscal Year: 2013
    ..to study, in several closely interrelated projects, the cell and molecular biology and diseases of mammalian urothelium. Our research focuses on, as a central and unifying theme, a group of integral membrane proteins called ..
  33. Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography
    Yingtian Pan; Fiscal Year: 2007
    ..COCT allows noninvasive visualization of cross-sectional micro-morphology of urothelium and the underlying bladder wall (e.g...
  34. Hedgehog signaling links bladder injury and cancer
    DAVID MONTY BERMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): A variety of environmental insults induce the normally quiescent urothelium to mount a transient proliferative response and restore homeostasis...
  35. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil S Mandel; Fiscal Year: 2010
    ..This grant focuses on the attachment of urinary crystals to injured kidney papillary tip urothelium and the conditions and events that allow for crystal attachment...
  36. Urothelial ATP Signaling and Diabetic Bladder Dysfunction
    SYLVIA OTTILIE SUADICANI; Fiscal Year: 2013
    ..ATP released from parasympathetic fibers can excite the detrusor muscle, and ATP released from the urothelium in response to bladder distension can indirectly modulate detrusor contractility by activating afferent fibers, ..
  37. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2009
    ..by neurotrophic factors released within the bladder, (4) Bidirectional chemical communication between the urothelium and adjacent nerves plays a role in sensory mechanisms as well as in epithelial cell function in the urinary ..
  38. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
    ..p53 alterations are involved in the transformation of normal urothelium to carcinoma-in-situ of the bladder and in the progression to invasive disease...
  39. Glycosaminoglycans For IC Pathophysiology and Prognosis
    Vinata Lokeshwar; Fiscal Year: 2005
    ..Since the luminal glycosaminoglycan (GAG) layer protects the bladder urothelium from noxious substances in urine, alterations in urothelial GAGs may be associated with IC pathophysiology...
  40. Regulaton of Urothelial Growth
    Tung Tien Sun; Fiscal Year: 2007
    ..and proximal urethra is lined by a cell type described in standard textbooks as the transitional epithelium or urothelium, which is characterized by a highly specialized apical cell surface covered by rigid-looking urothelial plaques ..
  41. INNOVATIVE INTRAVESICAL TREATMENT APPROACH FOR IC
    Veer Bhavanandan; Fiscal Year: 2001
    ..For example, prolonged binding of antibiotics to the urothelium may help to treat or prevent urinary tract infections.
  42. Mouse Models for Interstitial Cystitis
    Edward Schwarz; Fiscal Year: 2004
    ..We will induce chronic cystitis by continuous exposure of the urothelium to agents that disrupt the bladder lining by implanting indwelling bladder catheter in each mouse...
  43. Antiestrogen Regulation of Bladder Cancer
    Carolyn Smith; Fiscal Year: 2009
    ..Expression of ERa and ER[unreadable] have been reported in the urothelium and detrusor muscle of the human bladder, and studies in rats and mice indicate that ER[unreadable] is the ..
  44. Bladder Cancer and Urinary Schistosomiasis in Ghana
    Clive Shiff; Fiscal Year: 2004
    ..is a persistent infection of young people that becomes chronic as they age, providing a nidus in the urothelium, which may attract bacteria, viruses and other inflammation stimulants...
  45. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..Recent pathologic studies have shown that patient symptoms are correlated with lesions of the urothelium that lines the bladder and accumulation of mast cells in the underlying lamina propria...
  46. ROLE OF ISCHEMIA IN BLADDER OVERACTIVITY AND FIBROSIS
    MIKE SIROKY; Fiscal Year: 2003
    ..changes including bladder overactivity, abnormal smooth muscle reactivity, non-compliance, disruption of urothelium and fibrosis...
  47. A COMPARISON OF IN VIVO AND VITRO TISSUE ENGINEERING
    Bradley Kropp; Fiscal Year: 2004
    ..In the urinary tract, SIS induces regeneration of bladder that contains all three layers of the bladder (urothelium, smooth muscle and serosa), has contractile activity, and is innervated...
  48. Nociceptive Innervation and Receptors in the Bladder
    Gerard P Ahern; Fiscal Year: 2013
    ..there is considerable controversy as to whether TRPV1, a major "pain" receptor, is expressed in the bladder urothelium. TRPA1, another important nociceptive channel, has been identified in bladder but not rigorously localized...
  49. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    ..by applicant): Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium. During bladder inflammation, MIF production is upregulated in the bladder and MIF is released into the ..
  50. MARKERS OF EXFOLIATED BENIGN AND MALIGNANT BLADDER CELLS
    Carlos Cordon Cardo; Fiscal Year: 1991
    ..receptors, (a) by immunohistochemistry on tissue sections of human bladder tumors, reactive or metaplastic urothelium in inflammatory processes and normal urothelium, (b) by immunocytochemistry on cytology smears of exfoliated ..
  51. TRANSGENIC MOUSE MODELS FOR STUDYING PROSTATE/GU DISEASE
    Jeffrey Gordon; Fiscal Year: 2002
    ..The second component focuses on the urothelium. The undamaged adult mouse urothelium undergoes very slow turnover, making it difficult to identify the ..
  52. Video Rate Optical Coherence Tomography for Early Stage Cancer Visualization
    Paul Amazeen; Fiscal Year: 2009
    ..Currently up to 6 random biopsies of normal appearing urothelium are taken in patients presenting with superficial bladder cancer at the time of the resection or biopsy of the ..
  53. SELECTED MARKERS IN NONINVASIVE BLADDER TUMORS
    FRITZ HERZ; Fiscal Year: 1992
    ..We postulate that the factors governing the natural history of papillary tumors are vested in the urothelium periphera to tumors...
  54. STRUCTURE AND DYNAMICS OF MAMMALIAN UROTHELIAL PLAQUES
    Tung Tien Sun; Fiscal Year: 2003
    ..the assembly and regulation of the urothelial plaques that cover almost the entire apical surface of mammalian urothelium. These plaques represent two dimensional crystals of hexagonally arranged 16-nm particles, that are composed of ..
  55. Inducible Gene Expression in Mouse Urothelium
    Jay Reeder; Fiscal Year: 2004
    ..of an experimental system for the temporal and tissue-specific control of gene expression in the mouse urothelium. The model system will be validated by demonstration of controlled expression of the erbB2 oncogene...
  56. PLA2 activation by mast cell tryptase in IC
    Jane McHowat; Fiscal Year: 2007
    ..is an inflammatory bladder condition with unknown etiology, although a defect in bladder cytoprotection by the urothelium and a pathophysiologic role for the mast cell has been implicated...
  57. Capsaicin for chemoprevention of transition cell carcinoma of the bladder
    Rita Ghosh; Fiscal Year: 2009
    ..It is very expensive to monitor and treat this form of bladder cancer. The urothelium is highly susceptible to carcinogen-induced cancer such as carcinogens from cigarette smoke...
  58. VOLUME MICROPROBE TM ASSISTED BLADDER BIOPSY
    Robert Nordstrom; Fiscal Year: 1999
    ..spectrophotometer (CystoProbe) will examine these sites and differentiate neoplastic from non-neoplastic urothelium, and eventually, provide objective aid for staging and grading...
  59. TISSUE BLOOD GROUP ANTIGENS IN UROTHELIAL NEOPLASIA
    Catherine Limas; Fiscal Year: 1992
    ..for the ultrastructural demonstration of blood group related antigens (BG Ags) in normal and neoplastic urothelium. This will enable us to discriminate between cell surface and intracellular antigenic reactivity and, also, to ..
  60. Molecular Diversity in Bladder Cancer
    Wadih Arap; Fiscal Year: 2009
    ..Here, we propose to define the cellular and molecular differences that exist (i) in normal urothelium and (ii) in bladder cancer...
  61. ACTIVATION OF CARCINOGENS BY UROTHELIUM IN VITRO
    Santhanam Swaminathan; Fiscal Year: 1991
    ..The information gained from these studies will be useful in identifying the key metabolic factors that might be involved in susceptibility to arylamine-induced bladder carcinogenesis...
  62. PROTEINS AS SIGNALS IN UROTHELIAL CELL PROLIFERATION
    James Bassuk; Fiscal Year: 2007
    Understanding how the urothelium grows and differentiates is central to understanding a number of bladder diseases...
  63. AN IN VITRO MODEL FOR EVALUATION OF IC THERAPIES
    Peter Mundel; Fiscal Year: 2004
    ..immortalized human urothelial cell lines that retain key differentiated features of the highly specialized urothelium. This model will eliminate the need for unpredictable, short-lived primary cultures obtained from human subjects,..
  64. CELL CELL INTERACTIONS IN BLADDER DEVELOPMENT
    Laurence Baskin; Fiscal Year: 1999
    ..Bladder mesenchyme will be grown in association with bladder urothelium and the resultant tissue recombinants will be analyzed for expression of smooth muscle...
  65. REGULATION OF UROTHELIAL CELL BEHAVIOR BY SPARC
    James Bassuk; Fiscal Year: 2006
    Understanding how the urothelium grows and differentiates is central to understanding a number of bladder diseases. Being able to modulate these processes would allow us to improve how we repair urinary tract abnormalities in children...
  66. Identification of Genes Involved in Bladder Cancer
    John Clifford; Fiscal Year: 2007
    ..SV40 T) is expressed under the control of the uroplakin promoter, which restricts expression to the bladder urothelium. These mice (UPII- SV40T) develop TCC, which is preceded by a condition resembling human CIS...
  67. PROGNOSTIC MARKERS OF URINARY BLADDER CANCER
    H Grossman; Fiscal Year: 1999
    ..Functional proteins that have demonstrated differential expression on a normal and malignant urothelium will be evaluated for utility as predictive markers of bladder cancer...