urothelium

Summary

Summary: The epithelial lining of the URINARY TRACT.

Top Publications

  1. pmc Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux
    P Hu
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology, New York, New York 10016, USA
    J Cell Biol 151:961-72. 2000
  2. pmc Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
    Erika M Wolff
    Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Res 70:8169-78. 2010
  3. pmc Uroplakin gene expression by normal and neoplastic human urothelium
    E D Lobban
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds, United Kingdom
    Am J Pathol 153:1957-67. 1998
  4. doi A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder
    S Roperto
    Department of Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:95-108. 2010
  5. pmc An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor
    Jayoung Kim
    Urological Diseases Research Center, Children s Hospital Boston, Boston, MA 02115, USA
    In Vitro Cell Dev Biol Anim 47:2-9. 2011
  6. pmc Uroplakins in urothelial biology, function, and disease
    Xue ru Wu
    Department of Urology, New York University Langone Medical Center, New York, USA
    Kidney Int 75:1153-65. 2009
  7. doi Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
    Peter J Goebell
    Department of Urology, University Clinic of Erlangen, Erlangen, Germany
    Urol Oncol 28:409-28. 2010
  8. ncbi Intracellular bacterial biofilm-like pods in urinary tract infections
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 301:105-7. 2003
  9. pmc Differentiation potential of urothelium from patients with benign bladder dysfunction
    Jennifer Southgate
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York, UK
    BJU Int 99:1506-16. 2007
  10. pmc Cell biology and physiology of the uroepithelium
    Puneet Khandelwal
    Univ of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 297:F1477-501. 2009

Detail Information

Publications267 found, 100 shown here

  1. pmc Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux
    P Hu
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology, New York, New York 10016, USA
    J Cell Biol 151:961-72. 2000
    b>Urothelium synthesizes a group of integral membrane proteins called uroplakins, which form two-dimensional crystals (urothelial plaques) covering >90% of the apical urothelial surface...
  2. pmc Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
    Erika M Wolff
    Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Res 70:8169-78. 2010
    ..patterns between noninvasive and invasive UC and the DNA methylation patterns between normal-appearing urothelium from bladders with cancer and urothelium from cancer-free bladders...
  3. pmc Uroplakin gene expression by normal and neoplastic human urothelium
    E D Lobban
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds, United Kingdom
    Am J Pathol 153:1957-67. 1998
    ..Normal urothelium expressed mRNA for all four uroplakins, although UPIII could be detected only by ribonuclease protection assay...
  4. doi A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder
    S Roperto
    Department of Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:95-108. 2010
    ..High-grade carcinomas, and low and high-grade invasive tumours, are less commonly seen. Bovine papillomavirus (BPV) infection and ingestion of bracken fern both play a central role in carcinogenesis of these lesions...
  5. pmc An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor
    Jayoung Kim
    Urological Diseases Research Center, Children s Hospital Boston, Boston, MA 02115, USA
    In Vitro Cell Dev Biol Anim 47:2-9. 2011
    Studies of the urothelium, the specialized epithelial lining of the urinary bladder, are critical for understanding diseases affecting the lower urinary tract, including interstitial cystitis, urinary tract infections and cancer...
  6. pmc Uroplakins in urothelial biology, function, and disease
    Xue ru Wu
    Department of Urology, New York University Langone Medical Center, New York, USA
    Kidney Int 75:1153-65. 2009
    b>Urothelium covers the inner surfaces of the renal pelvis, ureter, bladder, and prostatic urethra...
  7. doi Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
    Peter J Goebell
    Department of Urology, University Clinic of Erlangen, Erlangen, Germany
    Urol Oncol 28:409-28. 2010
    ..The molecular pathogenesis of high-grade noninvasive papillary tumors and of T1 tumors is not yet clear, and possibilities are discussed...
  8. ncbi Intracellular bacterial biofilm-like pods in urinary tract infections
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 301:105-7. 2003
    ..The discovery of intracellular biofilm-like pods explains how bladder infections can persist in the face of robust host defenses...
  9. pmc Differentiation potential of urothelium from patients with benign bladder dysfunction
    Jennifer Southgate
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York, UK
    BJU Int 99:1506-16. 2007
    ....
  10. pmc Cell biology and physiology of the uroepithelium
    Puneet Khandelwal
    Univ of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 297:F1477-501. 2009
    ..Finally, we describe potential mechanisms by which the uroepithelium can transmit information about the urinary space to the other tissues in the bladder proper...
  11. ncbi Focus on bladder cancer
    Colin P N Dinney
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX USA
    Cancer Cell 6:111-6. 2004
  12. ncbi Gemcitabine plus cisplatin versus gemcitabine plus carboplatin as first-line chemotherapy in advanced transitional cell carcinoma of the urothelium: results of a randomized phase 2 trial
    Luigi Dogliotti
    Unit of Medical Oncology, University of Torino, San Luigi Hospital, Orbassano Torino, Italy
    Eur Urol 52:134-41. 2007
    ..of gemcitabine-cisplatin (GP) and gemcitabine-carboplatin (GC) in patients with advanced transitional cell carcinoma of the urothelium (TCC), with the main objective to demonstrate a reduction in toxicity of at least 25% in the GC arm.
  13. pmc Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine
    Pi che Chen
    Department of Life Science, National Chung Cheng University, Min Hsiung, Chia Yi, Taiwan
    BMC Med Genomics 4:45. 2011
    ..Previous studies have identified several tumor-related genes that are hypermethylated in bladder cancer; however the DNA methylation profile of bladder cancer in Taiwan is not fully understood...
  14. doi Bovine papillomavirus type 2 infects the urinary bladder of water buffalo (Bubalus bubalis) and plays a crucial role in bubaline urothelial carcinogenesis
    Sante Roperto
    Dipartimento di Patologia e Sanita Animale, Sezione Malattie Infettive, Facolta di Medicina Veterinaria, Universita di Napoli Federico II, Napoli, Italy
    J Gen Virol 94:403-8. 2013
    ..Our results indicate that the E5-PDGF β receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes...
  15. pmc All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms
    Joshua R Mauney
    Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts, USA
    PLoS ONE 5:e11513. 2010
    The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that acts as a specialized permeability barrier that protects the underlying tissue from urine via expression of a highly specific group of ..
  16. ncbi Fibroblast growth factors and their receptors in transitional cell carcinoma
    Nicholas P Munro
    Cancer Research United Kingdom Clinical Centre in Leeds, St James s University Hospital, Leeds, United Kingdom
    J Urol 169:675-82. 2003
    ..We examined these possibilities in light of the published literature...
  17. doi Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro
    Peter C Rubenwolf
    Jack Birch Unit for Molecular Carcinogenesis, Department of Biology, University of York, York, UK
    Eur Urol 56:1013-23. 2009
    b>Urothelium is generally considered to be impermeable to water and constituents of urine...
  18. ncbi Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium
    Prasad Acharya
    Renal Electrolyte Division, Department of Medicine, Laboratory of Epithelial Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 287:F305-18. 2004
    ....
  19. pmc Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases
    Xiang Tian Kong
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 167:1195-204. 2004
    The apical surface of mouse urothelium is covered by two-dimensional crystals (plaques) of uroplakin (UP) particles. To study uroplakin function, we ablated the mouse UPII gene...
  20. ncbi Bladder permeability barrier: recovery from selective injury of surface epithelial cells
    John Lavelle
    Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Renal Physiol 283:F242-53. 2002
    ..To perform this function, the urothelium maintains a tight permeability barrier...
  21. pmc Differentiation of human bone marrow mesenchymal stem cells into bladder cells: potential for urological tissue engineering
    Hong Tian
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Tissue Eng Part A 16:1769-79. 2010
    ..Simultaneous differentiation of human BMSCs into smooth muscle cells (SMCs) and urothelium would be beneficial for clinical applications in bladder regeneration for patients with bladder exstrophy or ..
  22. ncbi No evidence for involvement of beta-catenin and APC in urothelial carcinomas
    Robert Stoehr
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Int J Oncol 20:905-11. 2002
    ..Other wnt pathway members, such as axin, may play an important role in urothelial carcinogenesis...
  23. doi Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    Shugo Suzuki
    Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Toxicol Sci 113:349-57. 2010
    ..This strongly supports the previous conclusion in studies with muraglitazar that this is a rat-specific phenomenon and does not pose a urinary bladder cancer risk to humans treated with these agents...
  24. doi Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells
    Ana Charrua
    Institute of Histology and Embryology, Instituto de Ciencias Biomedicas Abel Salazar, University of Porto, Porto, Portugal
    J Urol 182:2944-50. 2009
    ..We investigated the expression and functional status of TRPV1 receptor in human urothelial cells...
  25. doi Golgi apparatus fragmentation as a mechanism responsible for uniform delivery of uroplakins to the apical plasma membrane of uroepithelial cells
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    Biol Cell 102:593-607. 2010
    ..We have used the culture model of UCs with the capacity to undergo terminal differentiation to study the process of uniform delivery of DFVs to the APM and to elucidate the mechanisms involved...
  26. ncbi Urothelial carcinomas arising in arsenic-contaminated areas are associated with hypermethylation of the gene promoter of the death-associated protein kinase
    W T Chen
    Department of Pathology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Histopathology 51:785-92. 2007
    ..The aim was to determine whether hypermethylation of death-associated protein kinase (DAPK) gene is associated with chronic arsenic exposure...
  27. ncbi P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis
    H V Tempest
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    BJU Int 93:1344-8. 2004
    ..the expression of P2X(3) receptors (implicated in the pathophysiology of pain) is altered in human bladder urothelium from patients with interstitial cystitis (IC, a major symptom of which is pain), and as P2X(2) receptors can be ..
  28. ncbi Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation
    Z T Zhang
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 20:1973-80. 2001
    ..Using a urothelium-specific promoter of the uroplakin II gene, we showed earlier in transgenic mice that the urothelial expression ..
  29. pmc Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function
    Birthe Schnegelsberg
    Department of Neuroscience, Roche Palo Alto, Palo Alto, California, USA
    Am J Physiol Regul Integr Comp Physiol 298:R534-47. 2010
    ..sensory function, we generated a transgenic mouse model of chronic NGF overexpression in the bladder using the urothelium-specific uroplakin II (UPII) promoter...
  30. ncbi Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression
    Anita Sabichi
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 175:1133-7. 2006
    ..Cell lines have become an essential component for the investigation of cancer. We have developed a panel of cell lines derived from human urothelial cancers and we describe some of their important characteristics...
  31. ncbi Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines
    Darren C Tomlinson
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, United Kingdom
    Cancer Res 65:10441-9. 2005
    ..FGFR3 was identified as the major family member expressed in both normal human urothelium and cultured normal human urothelial (NHU) cells and was expressed as the IIIb isoform...
  32. ncbi Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients
    Hiroshi Tsuruta
    Department of Urology, Akita University School of Medicine, Akita, Japan
    Cancer Res 66:8389-96. 2006
    PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate an urothelium-specific null mutation of Pten in mice [FabpCrePten(flox/flox) (FPten(flox/flox)) mice]...
  33. ncbi Characterization of the purinergic receptor subtype on guinea-pig suburothelial myofibroblasts
    Gui Ping Sui
    Institute of Urology, University College London, London, UK
    BJU Int 97:1327-31. 2006
    ....
  34. ncbi The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis
    Grannum R Sant
    Department of Urology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Urology 69:34-40. 2007
    ....
  35. doi Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer
    Fiona M Platt
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, United Kingdom
    Clin Cancer Res 15:6008-17. 2009
    ..Our aim was to assess the frequency and distribution of pathway alterations in bladder cancer...
  36. ncbi Botulinum toxin A inhibits ATP release from bladder urothelium after chronic spinal cord injury
    Mohit Khera
    Scott Department of Urology, Baylor College of Medicine, One Baylor Plaza, Alkek Building N720, Houston, TX 77030, USA
    Neurochem Int 45:987-93. 2004
    ..examined to demonstrate if spinal cord injury (SCI) modulates the basal or evoked release of ATP from bladder urothelium and whether intravesical botulinum toxin A (BTX-A) administration inhibits urothelial ATP release, a measure of ..
  37. pmc Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement
    Feng Xia Liang
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology
    J Cell Biol 171:835-44. 2005
    Although the epithelial lining of much of the mammalian urinary tract is known simply as the urothelium, this epithelium can be divided into at least three lineages of renal pelvis/ureter, bladder/trigone, and proximal urethra based on ..
  38. pmc Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells
    Emma J Chapman
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds LS97TF, United Kingdom
    Mol Cancer Res 6:1154-68. 2008
    ..Our data supports the concept of both telomere-based and non-telomere effects of telomerase and provides further rationale for the use of telomerase inhibitors in UC...
  39. ncbi Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability
    Ping Hu
    Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, NY 10016, USA
    Am J Physiol Renal Physiol 283:F1200-7. 2002
    ..J Cell Biol 151: 961-972, 2000). Our results indicate that normal mouse urothelium exhibits high transepithelial resistance and low urea and water permeabilities...
  40. pmc ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells
    Edward C Y Wang
    Renal Electrolyte Division and Laboratory of Epithelial Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 115:2412-22. 2005
    ....
  41. pmc Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model
    C Escudero-Lourdes
    Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, San Luis Potosi, SLP 78240, Mexico
    Toxicol Appl Pharmacol 244:162-73. 2010
    ..Taken together these results support the notion that chronic inflammation is associated within MMA(III)-induced cell transformation and may act as a promoting factor in UROtsa cell transformation...
  42. pmc A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer
    Jialou Zhu
    Beijing Genomics Institute at Shenzhen, Shenzhen, China
    PLoS ONE 6:e28223. 2011
    ..DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers. A systematic study of methylome and transcriptome in bladder urothelial carcinoma has never been reported...
  43. pmc Identification of genes correlated with early-stage bladder cancer progression
    Randolph Stone
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center Shreveport and Feist Weiller Cancer Center, USA
    Cancer Prev Res (Phila) 3:776-86. 2010
    ..expressed (> or =3-fold difference at one or more time points) between wild-type and UPII-SV40Tag urothelium during the time course of tumor development...
  44. doi Impact of gender on bladder cancer incidence, staging, and prognosis
    Harun Fajkovic
    Department of Urology and Division of Medical Oncology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA
    World J Urol 29:457-63. 2011
    ..Our aim was to review the literature on the effect of gender on bladder cancer incidence, biology, mortality, and treatment...
  45. doi The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack
    J W M Yuen
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
    J Ethnopharmacol 118:324-30. 2008
    ..The effects of Lingzhi antioxidants on oxidative DNA damage and oxidative stress were investigated, in order to understand their roles in bladder chemoprevention...
  46. ncbi The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
    Milan Chromek
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nat Med 12:636-41. 2006
    ..In addition, clinical E. coli strains that were more resistant to LL-37 caused more severe urinary tract infections than did susceptible strains. Thus, cathelicidin seems to be a key factor in mucosal immunity of the urinary tract...
  47. ncbi Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway
    E J Chapman
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Oncogene 25:5037-45. 2006
    ..The production of genetically normal but immortal NHUC lines now provides a valuable platform for experiments to examine the timing and combination of events necessary for UCC tumorigenesis...
  48. pmc Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner
    E Di Martino
    Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Oncogene 28:4306-16. 2009
    ..Our results indicate that the effects of mutant FGFR3 are both cell type specific and mutation specific. Mutant FGFR3 may confer a selective advantage in the urothelium by overcoming normal contact inhibition of proliferation.
  49. ncbi High urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissues
    David A Spector
    Division of Renal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 292:F467-74. 2007
    ..are consistent with the notion that urea and creatinine are continuously reabsorbed from the urine across the urothelium, urea in part via UT-B, and that urine is thus altered in its passage through the urinary tract...
  50. pmc Urinary bladder smooth muscle engineered from adipose stem cells and a three dimensional synthetic composite
    Gregory S Jack
    Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States
    Biomaterials 30:3259-70. 2009
    ..Our study demonstrates the feasibility and short term physical properties of bladder tissue engineered from adipose stem cells...
  51. doi Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas
    Gamze Donmez
    Adana Numune Education and Research Hospital, Department of Pathology, Adana, Turkey
    Pathol Res Pract 205:854-7. 2009
    ..014, r=-0.21). Increased VEGF and MMP-9 expression as well as decreased TSP-1 expression may play considerable roles in the invasion and differentiation of urothelial carcinoma...
  52. doi Expression and clinical significance of hepaCAM and VEGF in urothelial carcinoma
    Shuzhe Yang
    Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China
    World J Urol 28:473-8. 2010
    ....
  53. pmc Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
    Joel D Schilling
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:4203-8. 2003
    ..These results demonstrated that bladder epithelial cells play a critical role in TLR4-mediated innate immunity in vivo during a mucosal bacterial infection...
  54. doi The human urothelium consists of multiple clonal units, each maintained by a stem cell
    Nadine T Gaisa
    Institute of Pathology RWTH Aachen University, Aachen, Germany
    J Pathol 225:163-71. 2011
    Little is known about the clonal architecture of human urothelium. It is likely that urothelial stem cells reside within the basal epithelial layer, yet lineage tracing from a single stem cell as a means to show the presence of a ..
  55. doi Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo
    Ting Tsz Ou
    Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Ethnopharmacol 135:162-72. 2011
    ..Extracts of Paeonia lactiflora Pall (RPA), a traditional Chinese medicines has been shown to treat cancers...
  56. doi Immortalisation of normal human urothelial cells compromises differentiation capacity
    Nikolaos T Georgopoulos
    Jack Birch Unit for Molecular Carcinogenesis, Department of Biology, University of York, York, UK
    Eur Urol 60:141-9. 2011
    ..Although tumour grade is an independent prognostic marker for urothelial carcinoma (UC), the molecular events underpinning the loss of urothelial differentiation are poorly understood...
  57. doi The WHO classification of 1973 is more suitable than the WHO classification of 2004 for predicting survival in pT1 urothelial bladder cancer
    Wolfgang Otto
    Department of Urology, University of Regensburg, Regensburg, Erlangen, Germany
    BJU Int 107:404-8. 2011
    ..To ascertain which of the currently defined World Health Organization (WHO) grading classifications of pT1 urothelial bladder cancer (BC), published in 1973 and 2004, is more suitable for predicting outcome...
  58. doi Molecular pathogenesis and diagnostics of bladder cancer
    Anirban P Mitra
    Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Annu Rev Pathol 4:251-85. 2009
    ..The future of bladder cancer patient management will rely on the use of molecular tests to reliably diagnose the presence of disease, predict individual tumor behavior, and suggest potential targeted therapeutics...
  59. ncbi Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma
    Ute Gabriel
    Department of Urology, Mannheim Medical Center, University of Heidelberg, 68167 Mannheim, Germany
    Oncol Rep 20:1419-23. 2008
    ..conclusion, bcl-2 AS-ODNs show significantly higher cell mortality in TCC cells, whereas toxic effects on normal urothelium seem to be minor...
  60. doi Efficacy of a broad host range lytic bacteriophage against E. coli adhered to urothelium
    Sanna Sillankorva
    Department of Biological Engineering, University of Minho, Braga, Portugal
    Curr Microbiol 62:1128-32. 2011
    Persistent urinary tract infections (UTI) are often caused by E. coli adhered to urothelium. This type of cells is generally recognized as very tolerant to antibiotics which renders difficult the treatment of chronic UTI...
  61. doi Immunohistochemical expression of muscarinic receptors in the urothelium and suburothelium of neurogenic and idiopathic overactive human bladders, and changes with botulinum neurotoxin administration
    Soumendra N Datta
    Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United Kingdom
    J Urol 184:2578-85. 2010
    ..we examined the immunohistochemical expression of muscarinic receptors types 1, 2 and 3 in the bladder urothelium and suburothelium of patients with neurogenic or idiopathic detrusor overactivity compared with that in controls...
  62. pmc Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium
    Sheila M Bell
    Perinatal Institute of Cincinnati Children s Hospital Medical Center, Division of Neonatology Perinatal Pulmonary Biology, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 358:79-90. 2011
    Kruppel-like transcription factor 5 (Klf5) was detected in the developing and mature murine bladder urothelium. Herein we report a critical role of KLF5 in the formation and terminal differentiation of the urothelium...
  63. pmc Defining protein expression in the urothelium: a problem of more than transitional interest
    Weiqun Yu
    Laboratory of Voiding Dysfunction, Division of Renal Research, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Renal Physiol 301:F932-42. 2011
    The transitional epithelium of the bladder, the urothelium, is a challenging tissue to study due to its fragility, complex cellular makeup, stratified composition, and intimate connections to both neural and connective tissue elements...
  64. doi Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Clin Cancer Res 16:5654-63. 2010
    ..Foxo3a is a member of the Foxo transcription factor family that modulates the expression of various genes. We aimed to elucidate the role of Foxo3a in UC invasion...
  65. pmc Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome
    Hong Ying Huang
    Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Hum Pathol 38:1703-13. 2007
    As the terminal differentiation products of human urothelium, uroplakins (UPs) would be expected to diminish during urothelial tumorigenesis...
  66. doi Invasive micropapillary urothelial carcinoma of the bladder
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Department of Surgery, University of Cordoba Faculty of Medicine, E 14004, Cordoba, Spain
    Hum Pathol 41:1159-64. 2010
    ..The morphologic diversity of micropapillary carcinoma may represent a diagnostic pitfall in limited samples, where its distinction from conventional urothelial carcinoma is critical for its clinical management...
  67. ncbi Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis
    Emmanuel Graham
    Division of Urology, University of Maryland Medical Center, 22 S Greene Street, S8D18, Baltimore, MD 21201, USA
    Curr Urol Rep 7:440-6. 2006
    The human bladder urothelium (BU) and bladder urothelial cells (BUCs) play an important role in the normal functioning of bladder including bladder storage...
  68. doi Hyperplasia as a mechanism for rapid resealing urothelial injuries and maintaining high transepithelial resistance
    Tanja Višnjar
    Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia
    Histochem Cell Biol 137:177-86. 2012
    ....
  69. ncbi Gene deletion in urothelium by specific expression of Cre recombinase
    Lan Mo
    Dept of Urology, New York University Cancer Institute, New York Univ School of Medicine, New York, New York, USA
    Am J Physiol Renal Physiol 289:F562-8. 2005
    b>Urothelium that lines almost the entire urinary tract acts as a permeability barrier and is involved in the pathogenesis of major urinary diseases, including urothelial carcinoma, urinary tract infection, and interstitial cystitis...
  70. ncbi Differentiation of epithelial cells in the urinary tract
    Rok Romih
    Medical Faculty, Institute of Cell Biology, Ljubljana, Slovenia
    Cell Tissue Res 320:259-68. 2005
    ..epithelium covering the outer band of the outer medulla gradually changed from a two-layered to a three-layered urothelium with typical umbrella cells that contained all four uroplakins...
  71. ncbi The 2004 WHO classification of bladder tumors: a summary and commentary
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Int J Surg Pathol 13:143-53. 2005
    ..This scheme is meant to replace the 1973 WHO classification, but the use of both the 1973 and the latest WHO classifications is recommended until the latter is sufficiently validated...
  72. ncbi The uroepithelium: not just a passive barrier
    Gerard Apodaca
    Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Traffic 5:117-28. 2004
    ....
  73. pmc Urothelial plaque formation in post-Golgi compartments
    Samo Hudoklin
    Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 6:e23636. 2011
    ..With additional fusions and buddings, iFVs mature into mFVs, each carrying two urothelial plaques toward the apical surface of the umbrella cell...
  74. pmc Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder
    M R Freeman
    Urology Research, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 99:1028-36. 1997
    ..HER1) has been implicated in regenerative growth and proliferative diseases of the human bladder epithelium (urothelium), however a cognate HER1 ligand that can act as a growth factor for normal human urothelial cells (HUC) has not ..
  75. doi Formation and maintenance of blood-urine barrier in urothelium
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Lipiceva 2, SI 1000, Ljubljana, Slovenia
    Protoplasma 246:3-14. 2010
    ..In this review, we discuss recent discoveries on the role of tight junctions, dynamics of Golgi apparatus and post-Golgi compartments, and intracellular membrane traffic during the biogenesis and maintenance of blood-urine barrier...
  76. doi Interstitial cells in the urinary bladder--localization and function
    Karen D McCloskey
    School of Medicine, Dentistry and Biomedical Sciences, Medical Biology Centre, Belfast, Northern Ireland, UK
    Neurourol Urodyn 29:82-7. 2010
    ..This review summarizes the currently available literature on the localization and proposed functions of a novel group of cells in the urinary bladder known as interstitial cells or interstitial cells of Cajal (ICC)...
  77. ncbi Colistin interactions with the mammalian urothelium
    Jamie R Lewis
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555 0641, USA
    Am J Physiol Cell Physiol 286:C913-22. 2004
    ..Addition of colistin to the mucosal solution of the rabbit urinary bladder epithelium (urothelium) resulted in an increase in the transepithelial conductance...
  78. pmc Biology of urothelial tumorigenesis: insights from genetically engineered mice
    Xue ru Wu
    Department of Urology and Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Metastasis Rev 28:281-90. 2009
    b>Urothelium, one of the slowest cycling epithelia in the body, embodies a unique biological context for cellular transformation...
  79. pmc Directed differentiation of embryonic stem cells into bladder tissue
    Siam Oottamasathien
    Department of Urologic Surgery, Vanderbilt University Medical Center, and Division of Pediatric Urology, Vanderbilt Children s Hospital Nashville, TN 37232 2765, USA
    Dev Biol 304:556-66. 2007
    ..This model allows us to visualize the various stages in the differentiation of urothelium from ES cells, including the commitment to an endodermal cell lineage, with the temporal profile characterized ..
  80. ncbi Antigenic and ultrastructural markers associated with urothelial cytodifferentiation in primary explant outgrowths of mouse bladder
    Mateja Erdani Kreft
    Medical Faculty, Institute of Cell Biology, Ljubljana, Slovenia
    Cell Biol Int 26:63-74. 2002
    ..When examined at the ultrastructural level, the cultured urothelium was polarized and organized as a multilayered epithelium...
  81. pmc Temporally and spatially controllable gene expression and knockout in mouse urothelium
    Haiping Zhou
    Departments of Urology, New York Univ School of Medicine, New York, 10010, USA
    Am J Physiol Renal Physiol 299:F387-95. 2010
    b>Urothelium that lines almost the entire urinary tract performs important functions and is prone to assaults by urinary microbials, metabolites, and carcinogens...
  82. ncbi Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle
    Guangwei Min
    Structural Biology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Sci 116:4087-94. 2003
    ..Our results also have implications for the transmembrane signal transduction in urothelial cells as induced by the binding of uropathogenic E. coli to its uroplakin receptor...
  83. doi Apical plasma membrane traffic in superficial cells of bladder urothelium
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Ann N Y Acad Sci 1152:18-29. 2009
    ....
  84. doi Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment
    Alexander Roosen
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, UK
    Eur Urol 55:1440-8. 2009
    ..An increasing body of evidence suggests a possible role of suburothelial myofibroblasts (MFs) in bladder mechanosensation and in the pathophysiology of detrusor overactivity (DO)...
  85. doi Effects of PPAR agonists on proliferation and differentiation in human urothelium
    Claire L Varley
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York YO10 5YW, UK
    Exp Toxicol Pathol 60:435-41. 2008
    ..has indicated that they may invoke non-genotoxic carcinogenesis in the epithelial lining of the urinary tract (urothelium)...
  86. ncbi Enhanced adenosine triphosphate release from the urothelium of patients with painful bladder syndrome: a possible pathophysiological explanation
    Vivek Kumar
    Department of Urology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Urol 178:1533-6. 2007
    We established the level of adenosine triphosphate release by the urothelium in patients with painful bladder syndrome and compared it with that from the normal human bladder.
  87. ncbi Weekly paclitaxel and gemcitabine in advanced transitional-cell carcinoma of the urothelium: a phase II Hoosier Oncology Group study
    Jinxing Li
    Division of Hematology Oncology and Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Oncol 23:1185-91. 2005
    ..To evaluate the efficacy and toxicity of weekly paclitaxel and gemcitabine in patients with advanced transitional-cell carcinoma (TCC) of the urothelial tract...
  88. doi In vitro release of adenosine triphosphate from the urothelium of human bladders with detrusor overactivity, both neurogenic and idiopathic
    Vivek Kumar
    Department of Reconstructive Urology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Eur Urol 57:1087-92. 2010
    ..There is increased evidence to suggest a role for nonadrenergic-noncholinergic neurotransmission in the pathogenesis of bladder dysfunction...
  89. ncbi Urinary bladder urothelium: molecular sensors of chemical/thermal/mechanical stimuli
    Lori A Birder
    University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Department of Medicine, Pittsburgh, PA 15261, United States
    Vascul Pharmacol 45:221-6. 2006
    ..These and other findings highlight the functional importance of the urinary bladder urothelium and suggest that perturbations in urothelial targets and/or cell-cell interactions may lead to a number of ..
  90. pmc Removal of urothelium affects bladder contractility and release of ATP but not release of NO in rat urinary bladder
    Alvaro Munoz
    Scott Department of Urology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    BMC Urol 10:10. 2010
    The objective of our work was to investigate both the contractile function and the release of ATP and NO from strips of bladder tissue after removal of the urothelium.
  91. ncbi A surgical model of composite cystoplasty with cultured urothelial cells: a controlled study of gross outcome and urothelial phenotype
    M Fraser
    Department of Paediatric Urology, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    BJU Int 93:609-16. 2004
    ....
  92. ncbi Everything you wanted to know about the bladder epithelium but were afraid to ask
    S A Lewis
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555 0641, USA
    Am J Physiol Renal Physiol 278:F867-74. 2000
    The mammalian urinary bladder epithelium (urothelium) performs the important function of storing urine for extended periods, while maintaining the urine composition similar to that delivered by the kidneys...
  93. doi Involvement of vps33a in the fusion of uroplakin-degrading multivesicular bodies with lysosomes
    Xuemei Guo
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Traffic 10:1350-61. 2009
    The apical surface of the terminally differentiated mouse bladder urothelium is largely covered by urothelial plaques, consisting of hexagonally packed 16-nm uroplakin particles...
  94. ncbi Behavior of urothelial carcinoma with respect to anatomical location
    J W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 177:1715-20. 2007
    Urothelial carcinoma is a disease of the entire urothelium. Recent molecular insights suggest that the biology of some upper urinary tract and bladder urothelial carcinoma differ. These differences may affect tumor phenotype...
  95. ncbi A phase II trial of pemetrexed plus gemcitabine in locally advanced and/or metastatic transitional cell carcinoma of the urothelium
    H von der Maase
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Ann Oncol 17:1533-8. 2006
    ..current study were to determine overall response rate (ORR), progression-free survival, overall survival and safety and toxicity in chemonaive patients with locally advanced and/or metastatic transitional cell carcinoma of the urothelium.
  96. ncbi [Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells]
    J Neuhaus
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
    Urologe A 46:1193-7. 2007
    ..The aim of the study is to define IL-6 target gene regulation in cultivated human detrusor smooth muscle cells...
  97. ncbi Molecular mediators of angiogenesis in bladder cancer
    S C Campbell
    Department of Urology, R H Lurie Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cancer Res 58:1298-304. 1998
    Bladder tumors are characterized by markedly increased angiogenesis when compared to the normal urothelium (NU) from which they are derived...
  98. ncbi Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia
    David A Spector
    Division of Renal Medicine, The Johns Hopkins Bayview Medical Center, Baltimore 21224, USA
    Am J Physiol Renal Physiol 282:F1034-42. 2002
    ..AQPs in genitourinary tract urothelia likely play a role in the regulation of epithelial cell volume and osmolality and may play a role in bulk water movement across urothelia...
  99. pmc Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer
    Darren C Tomlinson
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Cancer Res 69:4613-20. 2009
    ..Our results indicate that FGFR1 has significant effects on urothelial cell phenotype and may represent a useful therapeutic target in some cases of urothelial carcinoma...
  100. ncbi Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis
    Gennady Slobodov
    Department of Urology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Urol 171:1554-8. 2004
    ..concerning the etiology of interstitial cystitis (IC) the loss of impermeability and other abnormalities of the urothelium are features of the disease...
  101. ncbi Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis 46202, USA
    Cancer 101:957-62. 2004
    ..Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder...

Research Grants86

  1. Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography
    Yingtian Pan; Fiscal Year: 2007
    ..COCT allows noninvasive visualization of cross-sectional micro-morphology of urothelium and the underlying bladder wall (e.g...
  2. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..mimic the environment of chronic bladder inflammation and PBS/IC, mice with chronic overexpression of NGF in the urothelium (UPII-NGFv2) will be used to determine the role that NGF plays in mediating functional, neurochemical and ..
  3. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..mimic the environment of chronic bladder inflammation and PBS/IC, mice with chronic overexpression of NGF in the urothelium (UPII-NGFv2) will be used to determine the role that NGF plays in mediating functional, neurochemical and ..
  4. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
    ..p53 alterations are involved in the transformation of normal urothelium to carcinoma-in-situ of the bladder and in the progression to invasive disease...
  5. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2007
    ..by neurotrophic factors released within the bladder, (4) Bidirectional chemical communication between the urothelium and adjacent nerves plays a role in sensory mechanisms as well as in epithelial cell function in the urinary ..
  6. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2010
    ..We have identified a number of abnormalities in the urothelium of FIC bladders including alterations in barrier function, proliferation and growth, and a heightened ..
  7. Glycosaminoglycans For IC Pathophysiology and Prognosis
    Vinata Lokeshwar; Fiscal Year: 2005
    ..Since the luminal glycosaminoglycan (GAG) layer protects the bladder urothelium from noxious substances in urine, alterations in urothelial GAGs may be associated with IC pathophysiology...
  8. Regulaton of Urothelial Growth
    Tung Tien Sun; Fiscal Year: 2007
    ..and proximal urethra is lined by a cell type described in standard textbooks as the transitional epithelium or urothelium, which is characterized by a highly specialized apical cell surface covered by rigid-looking urothelial plaques ..
  9. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2009
    ..Examine impact of aging on the ability of the urothelium to function as a regulatory interface between physical, inflammatory and endocrine stimuli involved in muscle ..
  10. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2007
    ..Examine impact of aging on the ability of the urothelium to function as a regulatory interface between physical, inflammatory and endocrine stimuli involved in muscle ..
  11. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George A Kuchel; Fiscal Year: 2010
    ..Examine impact of aging on the ability of the urothelium to function as a regulatory interface between physical, inflammatory and endocrine stimuli involved in muscle ..
  12. MVAC IN BLADDER CANCER BASED ON P53 STATUS
    Richard Cote; Fiscal Year: 1999
    ..p53 alterations/mutations have been shown to be involved in the transformation of normal urothelium to carcinoma in situ of the bladder and in the progression to invasive disease...
  13. Mouse Models for Interstitial Cystitis
    Edward Schwarz; Fiscal Year: 2004
    ..We will induce chronic cystitis by continuous exposure of the urothelium to agents that disrupt the bladder lining by implanting indwelling bladder catheter in each mouse...
  14. Role of Gene Expression in Interstitial Cystitis
    CHARLES BUFFINGTON; Fiscal Year: 2007
    ..The specific objectives of this proposal are to: 1) investigate the differential expression of genes in urothelium and adrenal cortex between normal cats and cats with FIC using a general screening strategy called rapid ..
  15. Bladder Cancer and Urinary Schistosomiasis in Ghana
    Clive Shiff; Fiscal Year: 2004
    ..is a persistent infection of young people that becomes chronic as they age, providing a nidus in the urothelium, which may attract bacteria, viruses and other inflammation stimulants...
  16. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..Recent pathologic studies have shown that patient symptoms are correlated with lesions of the urothelium that lines the bladder and accumulation of mast cells in the underlying lamina propria...
  17. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..Recent pathologic studies have shown that patient symptoms are correlated with lesions of the urothelium that lines the bladder and accumulation of mast cells in the underlying lamina propria...
  18. ROLE OF ISCHEMIA IN BLADDER OVERACTIVITY AND FIBROSIS
    MIKE SIROKY; Fiscal Year: 2003
    ..changes including bladder overactivity, abnormal smooth muscle reactivity, non-compliance, disruption of urothelium and fibrosis...
  19. Bacterial Survival in the Mammalian Urothelium
    JOSEPH PALERMO; Fiscal Year: 2007
    ..We will use co-infection of UPEC and K-12 bacteria to determine how UPEC alter the urothelium to improve bacterial survival...
  20. TRANSGENIC MOUSE MODELS FOR STUDYING PROSTATE/GU DISEASE
    Jeffrey Gordon; Fiscal Year: 2002
    ..The second component focuses on the urothelium. The undamaged adult mouse urothelium undergoes very slow turnover, making it difficult to identify the ..
  21. A COMPARISON OF IN VIVO AND VITRO TISSUE ENGINEERING
    Bradley Kropp; Fiscal Year: 2004
    ..In the urinary tract, SIS induces regeneration of bladder that contains all three layers of the bladder (urothelium, smooth muscle and serosa), has contractile activity, and is innervated...
  22. Genes Inducing Bladder Smooth Muscle Formation
    Laurence Baskin; Fiscal Year: 2010
    ..The key question is what are the signals or gene products from the urothelium that control bladder smooth muscle formation...
  23. Genes Inducing Bladder Smooth Muscle Formation
    Laurence Baskin; Fiscal Year: 2007
    ..The key question is what are the signals or gene products from the urothelium that control bladder smooth muscle formation...
  24. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2010
    ..explores the role of integrins and integrin-signaling pathways within the epithelium lining the bladder - the urothelium - where almost nothing is known of their function...
  25. Video Rate Optical Coherence Tomography for Early Stage Cancer Visualization
    Paul Amazeen; Fiscal Year: 2007
    ..Currently up to 6 random biopsies of normal appearing urothelium are taken in patients presenting with superficial bladder cancer at the time of the resection or biopsy of the ..
  26. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium. During bladder inflammation, MIF production is upregulated in the bladder and MIF is released into the intraluminal space where it ..