connective tissue

Summary

Summary: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.

Top Publications

  1. ncbi Connective tissue: a body-wide signaling network?
    Helene M Langevin
    Department of Neurology, University of Vermont, College of Medicine, Burlington, 05405, USA
    Med Hypotheses 66:1074-7. 2006
  2. pmc Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration
    Malea M Murphy
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Development 138:3625-37. 2011
  3. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
  4. pmc Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
    Boris Hinz
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 180:1340-55. 2012
  5. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
  6. doi Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
  7. ncbi Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
  8. ncbi Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia
    Marc Schmidt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 279:8063-9. 2004
  9. doi Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis
    Efstathios Vassiliadis
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 16:426-33. 2011
  10. doi Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?
    Andres Hilfiker
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Langenbecks Arch Surg 396:489-97. 2011

Detail Information

Publications315 found, 100 shown here

  1. ncbi Connective tissue: a body-wide signaling network?
    Helene M Langevin
    Department of Neurology, University of Vermont, College of Medicine, Burlington, 05405, USA
    Med Hypotheses 66:1074-7. 2006
    Unspecialized "loose" connective tissue forms an anatomical network throughout the body. This paper presents the hypothesis that, in addition, connective tissue functions as a body-wide mechanosensitive signaling network...
  2. pmc Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration
    Malea M Murphy
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Development 138:3625-37. 2011
    ..b>Connective tissue fibroblasts also are likely to play a role in regeneration, as connective tissue fibrosis is a hallmark of ..
  3. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
    ....
  4. pmc Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
    Boris Hinz
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 180:1340-55. 2012
    ..in several fields, such as the following: i) force production by the myofibroblast and mechanisms of connective tissue remodeling; ii) factors controlling the expression of α-smooth muscle actin, the most used marker of ..
  5. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
    ..Zinc (Zn) is an essential trace element and it is abundant in connective tissues, however biological roles of Zn and its transporters in those tissues and cells remain unknown...
  6. doi Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
    ..Its role in aging of the connective tissue has not yet been established, even though the incidence of aging-related disorders in connective tissue-rich ..
  7. ncbi Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
    ..The purpose of this review is to present the current evidence demonstrating that the adventitial fibroblast acts as a key regulator of pulmonary vascular function and structure from the "outside-in."..
  8. ncbi Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia
    Marc Schmidt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 279:8063-9. 2004
    ..with three antibodies directed against different epitopes of the protein consistently show cytoglobin in connective tissue fibroblasts as well as in hepatic stellate cells...
  9. doi Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis
    Efstathios Vassiliadis
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 16:426-33. 2011
    ..The aim of this study was to assess whether levels of a type V collagen fragment, the propeptide CO5-1230, indicate the amount of collagen deposited during liver fibrosis...
  10. doi Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?
    Andres Hilfiker
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Langenbecks Arch Surg 396:489-97. 2011
    ..The purpose of this article is to review the progress of TE technology, focusing on mesenchymal stem cells (MSC) as a cell source for artificial functional tissue...
  11. pmc Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
    Helene M Langevin
    Department of Neurology, Given Building, University of Vermont, Burlington, VT 05405, USA
    BMC Musculoskelet Disord 10:151. 2009
    ..pathogenesis of chronic low back pain (LBP), there have been no previous studies quantitatively evaluating connective tissue structure in this condition...
  12. pmc Connective tissue fibroblasts and Tcf4 regulate myogenesis
    Sam J Mathew
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Development 138:371-84. 2011
    Muscle and its connective tissue are intimately linked in the embryo and in the adult, suggesting that interactions between these tissues are crucial for their development...
  13. ncbi Adventitial progenitor cells contribute to arteriosclerosis
    Evelyn Torsney
    Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, SW17 0RE London, UK
    Trends Cardiovasc Med 15:64-8. 2005
    ..Thus, these cells may be a source of smooth muscle cells and might have implications for cellular, genetic, and tissue engineering approaches to vascular disease...
  14. ncbi Pathologic changes in the pericoronal tissues of unerupted third molars
    S Rakprasitkul
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, 6 Yothi Street, Rajthevee, Bangkok 10400, Thailand
    Quintessence Int 32:633-8. 2001
    ..The purpose of this study was to determine whether the incidence of pathologic conditions affecting the pericoronal tissue of unerupted third molars justifies their routine removal...
  15. pmc Extracellular matrix mechanics in lung parenchymal diseases
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Respir Physiol Neurobiol 163:33-43. 2008
    ..Finally, we speculate about the possibility of using targeted tissue engineering to optimize treatment of these two major lung diseases...
  16. ncbi Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling
    Boris Hinz
    Laboratory of Cell Biophysics, Swiss Federal Institute of Technology, Bâtiment SG AA B 143, CH 1015 Lausanne, Switzerland
    Thromb Haemost 90:993-1002. 2003
    ..modulation represents a crucial step in granulation tissue contraction and in the production of the connective tissue deformations typical of fibrocontractive diseases...
  17. ncbi Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    J Hepatol 47:699-710. 2007
    b>Connective tissue growth factor (CTGF/CCN2) has been implicated in the pathogenesis of hepatic fibrosis and suggested as a downstream mediator of the fibrogenic master cytokine TGF-beta.
  18. doi Pseudotumours associated with metal-on-metal hip resurfacings
    H Pandit
    Nuffield Orthopaedic Centre, Oxford, England
    J Bone Joint Surg Br 90:847-51. 2008
    ..We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause...
  19. ncbi Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms
    Helene M Langevin
    Department of Neurology, Given C423, University of Vermont, Burlington, VT 05405, United States
    Med Hypotheses 68:74-80. 2007
    ..This article presents a new, testable pathophysiological model integrating connective tissue plasticity mechanisms with several well-developed areas of research on cLBP (pain psychology, postural ..
  20. ncbi Oral focal mucinosis: report of 15 cases and review of the literature
    Michael J Aldred
    Dorevitch Pathology, Heidelberg, Victoria, Australia
    Pathology 35:393-6. 2003
    ..To describe 15 cases of oral focal mucinosis (OFM) and compare these to previously reported cases...
  21. pmc Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 521:299-306. 1999
    ..This suggests an adaptation to acute physical loading also in non-bone-related collagen in humans...
  22. ncbi Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms
    M D Huffman
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Surgery 128:429-38. 2000
    Abdominal aortic aneurysms (AAAs) involve an unfavorable balance between the destruction and the repair of connective tissue proteins...
  23. pmc Chondroitin sulphate inhibits connective tissue mast cells
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, MA 02111, USA
    Br J Pharmacol 131:1039-49. 2000
    ..3. Immunologic stimulation of histamine secretion from rat connective tissue mast cells (CTMC) was also inhibited, but this effect was weaker in umbilical cord-derived human mast cells ..
  24. pmc Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular/connective tissue changes in scarring trachoma
    Victor H Hu
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 80:121-30. 2012
    ..This study supports the possibility that the immunofibrogenic response in scarring trachoma is partly stimulated by nonchlamydial bacterial infection, which is characterized by the expression of innate factors...
  25. ncbi Changes in connective tissue in patients with pelvic organ prolapse--a review of the current literature
    M H Kerkhof
    Kennemer Gasthuis Haarlem, Haarlem, The Netherlands
    Int Urogynecol J Pelvic Floor Dysfunct 20:461-74. 2009
    ..In 1996, Jackson presented a hypothesis on pelvic floor connective tissue that tried to explain the development of POP on a molecular level...
  26. ncbi Use of platelet gel with connective tissue grafts for root coverage: a randomized-controlled trial
    Huseyin Gencay Keceli
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Clin Periodontol 35:255-62. 2008
    ..Platelet-rich plasma (PRP) was speculated to be a promoter of periodontal regeneration. There are only a few clinical comparative studies using PRP in the treatment of gingival recession...
  27. ncbi Mutable collagenous tissue: overview and biotechnological perspective
    I C Wilkie
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 OBA, Scotland, UK
    Prog Mol Subcell Biol 39:221-50. 2005
    ..that MCT could be a source of, or inspiration for, (1) new pharmacological agents and strategies designed to manipulate therapeutically connective tissue mechanical properties and (2) new composite materials with biomedical applications.
  28. ncbi Subepithelial connective tissue grafts in the treatment of multiple recession-type defects
    Luiz Armando Chambrone
    Discipline of Periodontics, Faculty of Dentistry, Methodist University of Sao Paulo, Sao Bernardo do Campo, Brazil
    J Periodontol 77:909-16. 2006
    ..The objective of this study was to evaluate the results obtained with a connective tissue graft placed under a coronally advanced flap for the treatment of multiple gingival recessions.
  29. ncbi A histologic evaluation of various stages of palatal healing following subepithelial connective tissue grafting procedures: a comparison of eight cases
    Kristi M Soileau
    Department of Oral and Maxillofacial Pathology, Louisiana State University School of Dentistry, New Orleans, LA 70115, USA
    J Periodontol 77:1267-73. 2006
    ..The purpose of this study was to determine whether the length of time between a first procurement and a second would have any bearing on the quality of tissue available for recipient sites...
  30. doi Connective tissue configuration in the human liver hilar region with special reference to the liver capsule and vascular sheath
    Shogo Hayashi
    Aichi Medical University Education Center AMEC, 21 Yazako Karimata, Nagakute, Aichi, 480 1195, Japan
    J Hepatobiliary Pancreat Surg 15:640-7. 2008
    ....
  31. ncbi Structural and mechanical architecture of the intestinal villi and crypts in the rat intestine: integrative reevaluation from ultrastructural analysis
    Yasue Hosoyamada
    Department of Nutrition, Chiba College of Health Science, 2 10 1 Wakaba, Mihama ku, Chiba shi, Chiba, 261 0014, Japan
    Anat Embryol (Berl) 210:1-12. 2005
    ....
  32. ncbi Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy
    A Mobasheri
    Division of Veterinary Medicine, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom
    Histol Histopathol 24:347-66. 2009
    ....
  33. ncbi Ontogenetic decline of regenerative ability and the stimulation of human regeneration
    David M Gardiner
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, California 92697, USA
    Rejuvenation Res 8:141-53. 2005
    ..A second lesson is that connective tissue fibroblasts control regeneration, and that the unique regenerative ability of salamanders (the first step of ..
  34. pmc Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:345-63. 2011
    ..that monkey ONH connective tissues become hypercompliant in early experimental glaucoma (EEG), by using 3-D histomorphometric reconstructions, and to expand the characterization of EEG connective tissue deformation to nine EEG eyes.
  35. pmc Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue
    Edmar Zanoteli
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochim Biophys Acta 1802:659-72. 2010
    ..Muscle fibers located adjacent to the expanded connective tissue underwent extensive invagination of their sarcolemma, which resulted in the infiltration of the fibers by ..
  36. ncbi Peptides controlling stifness of connective tissue in sea cucumbers
    R Birenheide
    Basic Biology, Faculty of Bioscience and Biotechnology, Tokyo Institue of Technology, Japan
    Biol Bull 194:253-9. 1998
    ..The body wall dermis of sea cucumbers consists of catch connective tissue that is characterized by quick and drastic stiffness changes under nervous control...
  37. pmc Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling
    Brian C Tieu
    Department of Biochemistry, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Vasc Res 48:261-72. 2011
    ..Our objective was to explore the contribution of these cells to angiotensin II (Ang II)-induced aortic inflammation and adventitial expansion...
  38. ncbi Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration
    Mounir J Haurani
    Department of General Surgery, Hypertension and Vascular Research Division, Room 7044, E and R Building, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 52:143-9. 2008
    ..05). Our data suggest that Nox4 promotes Ang II-induced myofibroblast migration via an H(2)O(2)-dependent pathway. The data also suggest that Nox4 causes feedback inhibition of its own expression in adventitial myofibroblasts...
  39. ncbi Connective tissue structure of the tree shrew optic nerve and associated ageing changes
    Julie Albon
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 48:2134-44. 2007
    ..To identify the structure and composition of the tree shrew optic nerve to determine its potential as a model for glaucoma...
  40. ncbi Immunomodulation of TGF-beta 1 in mdx mouse inhibits connective tissue proliferation in diaphragm but increases inflammatory response: implications for antifibrotic therapy
    Francesca Andreetta
    Department of Neuroimmunology and Neuromuscular Diseases, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Neuroimmunol 175:77-86. 2006
    Irreversible connective tissue proliferation in muscle is a pathological hallmark of Duchenne muscular dystrophy (DMD), a genetic degenerative muscle disease due to lack of the sarcolemmal protein dystrophin...
  41. doi Zebrafish collagen XII is present in embryonic connective tissue sheaths (fascia) and basement membranes
    Hannah L Bader
    Universite de Lyon, Universite Lyon 1, France
    Matrix Biol 28:32-43. 2009
    ..exhibited a much broader expression pattern than previously thought: it was ubiquitously expressed in the connective tissue sheaths (fascia) that encase the tissues and organs of the body...
  42. ncbi A comparative study of the biocompatibility of three root-end filling materials in rat connective tissue
    Shahriar Shahi
    Department of Endodontics, Tabriz Faculty of Dentistry, Azarbaidjan Shargi, Iran
    J Endod 32:776-80. 2006
    The purpose of this study was to compare the biocompatibility of amalgam, gray MTA and white MTA in the connective tissue of rats. We used 45 Sprague-Dawley rats in this study. The rats were divided into three groups...
  43. ncbi Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans
    M A Rossi
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Hypertens 16:1031-41. 1998
    To investigate pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans.
  44. ncbi Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy
    Guilian Sun
    Department of Pediatrics, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Sci 267:48-56. 2008
    ..In the present study, the immunolocalization and mRNA expression of connective tissue growth factor (CTGF) in muscles from normal and dystrophic human muscles were examined with the goal of ..
  45. ncbi Connective tissue growth factor in drug-induced gingival overgrowth
    M I Uzel
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, MA 02118, USA
    J Periodontol 72:921-31. 2001
    ..This study assesses for the presence and localization of connective tissue growth factor (CTGF) in drug-induced gingival overgrowth tissues...
  46. ncbi Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice
    Denise M Inman
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    J Comp Neurol 462:431-49. 2003
    ..a unique wound healing response following spinal cord injury in which the lesion site fills in with a connective tissue matrix...
  47. ncbi The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice
    Michael P W Moos
    The Institute for Vascular Medicine, Friedrich Schiller University of Jena, Germany
    Arterioscler Thromb Vasc Biol 25:2386-91. 2005
    ..Cells of adaptive immunity have been implicated in atherogenesis. Though substantial information is available on immune cells in atherosclerotic lesions of the lamina intima, cells in the lamina adventitia have received less attention...
  48. ncbi Reactions of connective tissue to mineral trioxide aggregate and amalgam
    Mehmet Yaltirik
    Faculty of Dentistry, Department of Oral Surgery and Medicine, Istanbul University, Turkey
    J Endod 30:95-9. 2004
    The purpose of this study was to evaluate the subcutaneous connective tissue reactions to ProRoot, mineral trioxide aggregate (MTA; Dentsply), and Oralloy, high-copper amalgam (Coltene)...
  49. ncbi Tissue displacements during acupuncture using ultrasound elastography techniques
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    Ultrasound Med Biol 30:1173-83. 2004
    Acupuncture needle manipulation has been previously shown to result in measurable changes in connective tissue architecture in animal experiments...
  50. pmc The adventitia: a dynamic interface containing resident progenitor cells
    Mark W Majesky
    Seattle Children s Research Institute, Departments of Pediatric, Center for Cardiovascular Biology, and the Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98101, USA
    Arterioscler Thromb Vasc Biol 31:1530-9. 2011
    ..views of the tunica adventitia as a poorly organized layer of vessel wall composed of fibroblasts, connective tissue, and perivascular nerves are undergoing revision...
  51. ncbi Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?
    Mounir J Haurani
    Henry Ford Hospital, Detroit, Department of General Surgery, MI 48202 2689, USA
    Cardiovasc Res 75:679-89. 2007
    ..We will also survey other signaling pathways involving adventitial NAD(P)H oxidase ultimately leading to changes in vascular phenotype...
  52. pmc Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-))
    Jennifer Larusso
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Invest Dermatol 129:1388-94. 2009
    Pseudoxanthoma elasticum (PXE) is an autosomal recessive multisystem disorder characterized by ectopic connective tissue mineralization, with clinical manifestations primarily in the skin, eyes, and cardiovascular system...
  53. ncbi No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen
    Am J Physiol Endocrinol Metab 290:E163-E168. 2006
    ..Therefore, there is no effect of menstrual cycle phase, at rest or in response to an acute bout of exercise, on myofibrillar protein synthesis and muscle collagen synthesis in women...
  54. ncbi Connective tissue metabolism and gingival overgrowth
    P C Trackman
    Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Division of Oral Biology, Boston, MA 02118, USA
    Crit Rev Oral Biol Med 15:165-75. 2004
    ....
  55. ncbi Serum collagen type VI and XIV and hyaluronic acid as early indicators for altered connective tissue turnover in alcoholic liver disease
    F Stickel
    I. Department of Medicine, University of Erlangen-Nurnberg, Erlangen, Germany
    Dig Dis Sci 46:2025-32. 2001
    ..The correlation between procollagen-III-N-propeptide and TGF-beta1 emphasizes its role in hepatic fibrogenesis...
  56. pmc Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes
    Michael D Roberts
    Ocular Biomechanics, Legacy Health System, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:295-307. 2010
    ..To investigate the biomechanical response to IOP elevation of normal monkey eyes using eye-specific, three-dimensional (3-D) finite element (FE) models of the ONH that incorporate lamina cribrosa (LC) microarchitectural information...
  57. ncbi Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
    H M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    FASEB J 15:2275-82. 2001
    ..We hypothesize that 1) needle grasp is due to mechanical coupling between the needle and connective tissue with winding of tissue around the needle during needle rotation and 2) needle manipulation transmits a ..
  58. ncbi Influence of laser photobiomodulation upon connective tissue remodeling during wound healing
    Alena P Medrado
    Laboratory of Experimental Pathology, Oswaldo Cruz Foundation, Rua Waldemar Falcão, 121, Salvador, Bahia 40 296 710, Brazil
    J Photochem Photobiol B 92:144-52. 2008
    ..Thus, laser photobiomodulation was able to induce several modifications during the cutaneous healing process, especially in favoring newly-formed collagen fibers to be better organized and compactedly disposed...
  59. pmc Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma
    Michael D Roberts
    Ocular Biomechanics Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 50:681-90. 2009
    To characterize the trabeculated connective tissue microarchitecture of the lamina cribrosa (LC) in terms of total connective tissue volume (CTV), connective tissue volume fraction (CTVF), predominant beam orientation, and material ..
  60. ncbi Treatment of gingival recession: comparison of two techniques of subepithelial connective tissue graft
    Tolga F Tozum
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Periodontol 76:1842-8. 2005
    ..This clinical study was conducted to examine the coverage of gingival recession defects, where two different subepithelial connective tissue graft (SCTG) techniques (Langer and Langer and modified tunnel) were used.
  61. ncbi Estimation of Young's modulus and Poisson's ratio of soft tissue from indentation using two different-sized indentors: finite element analysis of the finite deformation effect
    A P C Choi
    Rehabilitation Engineering Centre, Kowloon Polytechnic University, Kowloon, China
    Med Biol Eng Comput 43:258-64. 2005
    ..After the finite deformation effect of indentation was considered, the error of the calculated Young's modulus could be controlled within 5% (a/h = 1) and 2% (a/h = 2) for deformation up to 10%...
  62. ncbi Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells
    Ayuko Hoshino
    Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    Biochem Biophys Res Commun 368:305-10. 2008
    ..These findings demonstrate that human vascular adventitia contains MPCs, and that hVAFs may be an ideal source for further experiments on stem cell biology and tissue engineering...
  63. ncbi Leukotriene formation by mouse connective tissue mast cells
    B A Jakschik
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110
    Eicosanoids 5:39-43. 1992
    ..Western blot analysis confirmed the presence of 5-lipoxygenase in connective tissue mast cells...
  64. ncbi Tissue response to a new methacrylate-based root canal sealer: preliminary observations in the subcutaneous connective tissue of rats
    Osvaldo Zmener
    Department of Adult Dental Care, Section of Endodontics, Faculty of Odontology, University of Buenos Aires, Republica Argentina
    J Endod 30:348-51. 2004
    ..Silicone tubes filled with EndoRez, a methacrylate-based root canal sealer, were implanted in the subcutaneous connective tissue of the rat...
  65. ncbi Single-tooth replacement by immediate implant and connective tissue graft: a 1-9-year clinical evaluation
    Andrea E Bianchi
    Department of Periodontology and Implantology, Istituto Stomatologico Italiano, Milan, Italy
    Clin Oral Implants Res 15:269-77. 2004
    ..the long-lasting efficacy of a combined surgical protocol, using immediate implant and subepithelial connective tissue graft for single-tooth replacement...
  66. ncbi Endothelin-1 expression in vascular adventitial fibroblasts
    Sheng Jun An
    Dept of Community Health Sciences, Faculty of Applied Health Sciences, Brock Univ, St Catharines, ON, Canada L2S 3Y6
    Am J Physiol Heart Circ Physiol 290:H700-8. 2006
    ..The results demonstrate that vascular adventitial fibroblasts are able to synthesize and release ET-1 in response to ANG II...
  67. pmc CAUDLES-EF: carotid automated ultrasound double line extraction system using edge flow
    Filippo Molinari
    Biolab Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129, Torino, Italy
    J Digit Imaging 24:1059-77. 2011
    ..Regarding the Figure of Merit (FoM), CALEXia and CULEXsa showed the values of 84.7% and 91.5%, respectively, while our new approach, CAUDLES-EF, performed the best at 94.8%, showing a good improvement compared to previous methods...
  68. ncbi Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling
    C D Jordan
    Department of Pathology, University of Washington, USA
    J Musculoskelet Neuronal Interact 6:366-7. 2006
  69. ncbi An ultrastructural study of connective tissue in mollusc integument: II. Gastropoda
    A Bairati
    Dipartimento di Fisiologia e Biochimica Generali, Sezione di Istologia e Anatomia Umana, Universita degli Studi di Milano, Italy
    Tissue Cell 33:426-38. 2001
    We studied the ultrastructure of the subepidermal connective tissue (SEC) in different zones of the integument in terrestrial, marine and freshwater gastropods (eight species)...
  70. ncbi Initial characterization of the microenvironment that regulates connective tissue degradation in amniochorion during normal human labor
    Guadalupe Estrada-Gutierrez
    Research Direction, Instituto Nacional de Perinatologia, Mexico City, Mexico
    Matrix Biol 24:306-12. 2005
    ..Initial characterization of the effect of different blood compartments on connective tissue degradation in amniochorion during human labor was explored...
  71. ncbi Water transport and IIF parameters for a connective tissue equivalent
    Saravana Kumar Balasubramanian
    Department of Mechanical Engineering, University of Minnesota, 111 Church Street SE, Minneapolis, MN 55455, USA
    Cryobiology 52:62-73. 2006
    ..The observed biophysics seems to indicate that cell-cell and cell-matrix interactions play a major role in ice propagation in TEs...
  72. ncbi PLGA nanofiber-coated silk microfibrous scaffold for connective tissue engineering
    Sambit Sahoo
    NUS Tissue Engineering Program, National University of Singapore, Singapore
    J Biomed Mater Res B Appl Biomater 95:19-28. 2010
    ..Although PLGA-based hybrid scaffolds have earlier been proposed for dense connective tissue engineering, rapid biodegradation of PLGA was a drawback...
  73. ncbi Short and long-term results of connective tissue manipulation and combined ultrasound therapy in patients with fibromyalgia
    Ilkim Citak-Karakaya
    Mugla University, Mugla School of Health Sciences, Mugla, Turkey
    J Manipulative Physiol Ther 29:524-8. 2006
    The aim of the study was to evaluate the short-term and 1-year follow-up results of connective tissue manipulation and combined ultrasound (US) therapy (US and high-voltage pulsed galvanic stimulation) in terms of pain, complaint of ..
  74. pmc Force transmission between synergistic skeletal muscles through connective tissue linkages
    Huub Maas
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
    J Biomed Biotechnol 2010:575672. 2010
    ..Future studies are needed to investigate the importance of intermuscular force transmission during movement in health and disease...
  75. ncbi Basaloid/follicular hyperplasia overlying connective tissue/mesenchymal hamartomas simulating basal cell carcinomas
    M E Stashower
    Department of Dermatology, National Naval Medical Center, Bethesda, Maryland, USA
    J Am Acad Dermatol 45:886-91. 2001
    ..antibodies, which may suggest differences in pathogenesis, were different in basaloid hyperplasia overlying connective tissue/mesenchymal hamartomas and BCC...
  76. ncbi The fine connective tissue architecture of the human ligamentum nuchae
    G M Johnson
    Department of Anatomy and Structural Biology, University of Otago School of Physiotherapy, Dunedin, New Zealand
    Spine (Phila Pa 1976) 25:5-9. 2000
    ..An anatomic study of the posterior midline structures of the cervical spine was performed using a new sheet-plastination (E12) technique in conjunction with gross anatomic dissection...
  77. pmc Light and scanning electron microscopic study on the lingual papillae and their connective tissue cores of the Cape hyrax Procavia capensis
    Ken Yoshimura
    Department of Anatomy, Faculty of Life Dentistry, The Nippon Dental University at Niigata, Niigata, Japan
    J Anat 213:573-82. 2008
    We examined the epithelial surface and connective tissue cores (CTCs) of each lingual papilla on the Paenungulata, Cape hyrax (Procavia capensis), by scanning electron microscopy and light microscopy...
  78. ncbi Diagnostic value of serum markers of connective tissue turnover for predicting histological staging and grading in patients with chronic hepatitis C
    Y Murawaki
    Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan
    J Gastroenterol 36:399-406. 2001
    ..CONCLUSIONS: These serum fibrotic markers, especially the serum HA test, would be clinically useful for assessing staging and grading in patients with chronic hepatitis C...
  79. ncbi Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms
    Federico E Parodi
    Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Vasc Surg 20:360-8. 2006
    ..The possibility that dietary ingestion of curcumin may have a beneficial effect in degenerative aortic aneurysms warrants further consideration...
  80. ncbi Zosteriform connective tissue nevus: a case report
    Shih Wei Yeh
    Department of Dermatology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Int J Dermatol 42:720-2. 2003
    Because of its distinctive clinical features and histopathological characteristics, zosteriform connective tissue nevus is considered a separate entity from other connective tissue nevi...
  81. doi A novel stiffening factor inducing the stiffest state of holothurian catch connective tissue
    Akira Yamada
    Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, Hyogo 651 2492, Japan
    J Exp Biol 213:3416-22. 2010
    The dermis of sea cucumbers is a catch connective tissue or mutable collagenous tissue that shows large changes in stiffness...
  82. pmc Fibroblast cytoskeletal remodeling contributes to connective tissue tension
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 226:1166-75. 2011
    The visco-elastic behavior of connective tissue is generally attributed to the material properties of the extracellular matrix rather than cellular activity...
  83. ncbi Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia
    Pattaratida Sa-nguanmoo
    Center of Excellence in Viral Hepatitis Research, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University
    J Med Assoc Thai 90:251-7. 2007
    b>Connective tissue growth factor (CTGF) has been proposed to play a key role in the pathogenesis of hepatic fibrosis in biliary atresia (BA)...
  84. ncbi The connective tissue and glial framework in the optic nerve head of the normal human eye: light and scanning electron microscopic studies
    Tokuhide Oyama
    Division of Microscopic Anatomy and Bio imaging, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arch Histol Cytol 69:341-56. 2006
    The arrangement of connective tissue components (i.e...
  85. ncbi Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate
    Roberto Holland
    Department of Restorative Dentistry, Faculty of Dentistry of Aracatuba, UNESP, Aracatuba, SP, Brazil
    Braz Dent J 13:23-6. 2002
    The purpose of this paper was to study the reaction of rat subcutaneous connective tissue to the implantation of dentin tubes filled with white mineral trioxide aggregate (MTA), a material that will be marketed...
  86. ncbi Contractile and connective tissue protein content of human skeletal muscle: effects of 35 and 90 days of simulated microgravity and exercise countermeasures
    Jacob M Haus
    Human Performance Laboratory, Ball State Univ, Muncie, IN 47306, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1722-7. 2007
    ..muscles are able to maintain the concentrations of the general protein pools and the main contractile and connective tissue elements...
  87. ncbi The echinoderm collagen fibril: a hero in the connective tissue research of the 1990s
    Greg Szulgit
    Department of Biology, McDaniel College, 2 College Hill, Westminster, MD 21157, USA
    Bioessays 29:645-53. 2007
    ..This information will be fundamental in understanding what holds collagenous tissues together at the fibrillar level, and could have important implications for people with Ehlers-Danlos syndrome...
  88. pmc Application of WGA lectin staining for visualization of the connective tissue in skeletal muscle, bone, and ligament/tendon studies
    Tatiana Y Kostrominova
    Department of Anatomy and Cell Biology, Indiana University School of Medicine Northwest, Gary, Indiana 46409 1008
    Microsc Res Tech 74:18-22. 2011
    ..Often in skeletal muscle research, immunostaining with antibodies against connective tissue or plasma membrane proteins (collagen 1, laminin, and caveolin 3) are used for this purpose...
  89. ncbi Epimuscular myofascial force transmission between antagonistic and synergistic muscles can explain movement limitation in spastic paresis
    Peter A Huijing
    Instituut voor Fundamentele en Klinische Bewegingswetenschappen, Faculteit Bewegingswetenschappen, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    J Electromyogr Kinesiol 17:708-24. 2007
    ....
  90. ncbi Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1
    Darcey Klaahsen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 18:719-26. 2007
    ..The results of this study merit the further investigation of the role of reactive oxidative species with regard to Nfkappab1 in the copper deficient rat heart...
  91. ncbi Comparison of 2 techniques of subepithelial connective tissue graft in the treatment of gingival recessions
    G Cordioli
    Department of Periodontology, University of Padova, Institute of Clinical Dentistry, Italy
    J Periodontol 72:1470-6. 2001
    BACKGROUND: The clinical outcome of connective tissue grafts in the treatment of gingival recessions has been documented in numerous studies...
  92. ncbi [Role of pericytes in mechanism of vessel neovascularisation in the regenerating connective tissue]
    V V Banin
    Department of Morphology, Russian State Medical University, Moscow
    Morfologiia 125:45-50. 2004
    ..electron microscopic study of cellular interrelations in the process of capillary growth in the regenerating connective tissue. The study was performed in 28 albino rats which have been implanted with different polymer nets in the ..
  93. ncbi Growth hormone and connective tissue in exercise
    S Doessing
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Copenhagen NV, Denmark
    Scand J Med Sci Sports 15:202-10. 2005
    ..a possible anabolic effect on myofibrillar muscle protein, we suggest a role for GH as an anabolic agent in connective tissue in human skeletal muscle and tendon...
  94. ncbi Regulation of connective tissue homeostasis in the skin by mechanical forces
    B Eckes
    Department of Dermatology, University of Cologne, Germany
    Clin Exp Rheumatol 22:S73-6. 2004
    ..of the skin to tensile forces and describes the adaptive phenotype of fibroblasts residing in the dermal connective tissue. Work from a number of different groups suggests that tension induces in these cells many biological ..
  95. ncbi Application of exogenous enzymes to beef muscle of high and low-connective tissue
    G A Sullivan
    Department of Animal Science, University of Nebraska, A213 AnS, Box 830908, Lincoln, NE 68583 0908, USA
    Meat Sci 85:730-4. 2010
    ..Sensory evaluation showed improvement (P<0.0009) for tenderness and connective tissue component and all except ginger had a lower shear force than the control (P<0.003)...
  96. ncbi Connective tissue graft to correct peri-implant soft tissue margin: A clinical report
    Jamil Awad Shibli
    Department of Periodontology, Dental Research Division, Guarulhos University, Sao Paulo, Brazil
    J Prosthet Dent 91:119-22. 2004
    This clinical report describes the use of a subepithelial connective tissue graft to recontour a soft tissue margin discrepancy for a single-implant crown in the anterior maxilla...
  97. ncbi Posterior subtenon triamcinolone acetonide for refractory diabetic macular edema
    Sophie J Bakri
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 4195, USA
    Am J Ophthalmol 139:290-4. 2005
    ..To evaluate posterior subtenon injection of triamcinolone acetonide for refractory diabetic macular edema (DME)...
  98. ncbi Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils
    L Y Sakai
    Shriners Hospital for Crippled Children, Portland, Oregon 97201
    J Biol Chem 266:14763-70. 1991
    Fibrillin, a connective tissue macromolecule (Mr = 350,000) which is normally insoluble in its tissue form, has been purified from the medium of human skin fibroblast and ligament cells in culture...
  99. ncbi Homeobox genes and connective tissue patterning
    G Oliver
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 121:693-705. 1995
    ..Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes...
  100. ncbi Intermuscular interaction between synergists in rat originates from both intermuscular and extramuscular myofascial force transmission
    Huub Maas
    Center for Human Movement Studies, School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA, USA
    Cells Tissues Organs 181:38-50. 2005
    ..a) after full longitudinal compartmental fasciotomy, and (b) after blunt dissection of the intermuscular connective tissue linkages between EDL and TA+EHL...
  101. ncbi Vitrectomy with or without arteriovenous adventitial sheathotomy for macular edema associated with branch retinal vein occlusion
    Shuichi Yamamoto
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba
    Am J Ophthalmol 138:907-14. 2004
    ..compare the results of vitrectomy with or without arteriovenous (AV) crossing sheathotomy for macular edema associated with branch retinal vein occlusion (BRVO)...

Research Grants122 found, 100 shown here

  1. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..The proposed studies will provide conceptual support of our hypothesis and position us to translate our investigation into a clinical study in obese patients with coronary artery disease. ..
  2. Mechanisms of oval cell activation and differentiation
    Bryon E Petersen; Fiscal Year: 2012
    ..Previous experiments have implicated connective tissue growth factor (CTGF), Notch-1, Wnt1, Somatostatin (SST), insulin-like growth factor binding protein 3 (..
  3. 2013 Elastin, Elastic Fibers &Microfibrils Gordon Research Conference &Gordon R
    Zsolt Urban; Fiscal Year: 2013
    ..systems, as well as with new and improved diagnostic and therapeutic strategies for acquired and genetic connective tissue disorders originating from derailed functions of the elastic fiber/microfibril system...
  4. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..are being investigated for treatment of cardiovascular disorders (stroke, myocardial infarction), diabetes, connective tissue disorders (cartilage defects, osteonecrosis, limb ischemia), chronic obstructive pulmonary disease, nervous ..
  5. Cardiac Dystrophy: Cellular Mechanisms
    NATALIA V SHIROKOVA; Fiscal Year: 2013
    ..The pathoanatomic basis for the loss of function is mainly the replacement of myocardium by connective tissue and fat (fibrosis)...
  6. Mechanisms of Metal Ion Regulation in Human Cells
    Svetlana Lutsenko; Fiscal Year: 2013
    ..Copper is an essential nutrient required for embryonic development, connective tissue formation, myelination of neurons, detoxification of radicals, and many other physiological processes...
  7. Mechanism of skin-specific targeting of adult stem cells
    Olga Igoucheva; Fiscal Year: 2013
    ..This proposal outlines a dedicated strategy of cell-based therapy aimed at the treatment of connective tissue disease in a clinically relevant model, epidermolysis bullosa, which provides an excellent genetic target ..
  8. PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGE
    HARRY ALAN QUIGLEY; Fiscal Year: 2013
    ..methods into cohesive glaucoma studies in normal mice and mice with targeted alterations in specific connective tissue molecules is the unified theme of the present application...
  9. Selective MRTF/SRF-Transcription Inhibitors: Novel Anti-fibrotics for IPF
    Vijaykumar M Baragi; Fiscal Year: 2013
    ..Outcomes measures include [unreadable]-smooth muscle actin ([unreadable]-SMA), connective tissue growth factor (CTGF) and MRTF...
  10. Urinary Biomarkers of Chronic Kidney Disease Pathology and Progression
    Sushrut S Waikar; Fiscal Year: 2013
    ..1L-18);urinary cystatin C;albumin;hepatocyte growth facmr (HGF);interferon-inducible protein (IP-10);and connective tissue growth factor (CTGF)...
  11. Role of the Leprecan Genes in Skeletal Formation
    Roy Morello; Fiscal Year: 2013
    ..3) enhance understanding of the Leprecan genes in skeletal development and other tissues, and 4) provide further insight into the role of these non-collagenous proteins in the etiology of human connective tissue disease, including OI.
  12. Matrix Metalloproteinase Regulation of Leukocyte Infiltration during Wound Repair
    LISA JOY MCCAWLEY; Fiscal Year: 2013
    ..including arrest on endothelium, migration through the endothelial barrier and directed migration through connective tissue towards the site of inflammation...
  13. Targeted Correction of Dominant Mutations of Type I Collagen Causing Severe OI
    David W Rowe; Fiscal Year: 2013
    ..osteogenesis imperfecta (OI) has been the paradigm for the study of a dominantly inherited disease of connective tissue resulting from a mutation that disrupts the three dimensional structure of a major extracellular protein...
  14. The Role of Perineurial Glia in PNS Regeneration
    GWENDOLYN LEWIS; Fiscal Year: 2013
    ..The complete nerve is formed of axons surrounded by several layers of ensheathing glia and connective tissue. Regeneration requires all the cells in these layers to precisely coordinate their behaviors to ensure ..
  15. Cellular Physiology of the Aqueous Outflow Pathway
    Haiyan Gong; Fiscal Year: 2013
    ..is localized near the inner wall endothelium of Schlemm's canal (SC) and the juxtacanalicular connective tissue (JCT)...
  16. Scleroderma Twin Study
    Carol A Feghali-Bostwick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic sclerosis (SSc;Scleroderma) is a connective tissue disease of unknown etiology that is associated with significant morbidity and mortality...
  17. FASEB SRC on Matricellular Proteins in Development, Health, and Disease
    Joanne E Murphy-Ullrich; Fiscal Year: 2013
    ..extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix)...
  18. Peptide therapeutics for inhibiting abdominal adhesions
    CYNTHIA ELLEN LANDER; Fiscal Year: 2012
    ..MK2 is implicated in the connective tissue growth factor (CTGF) and collagen type I up regulation that promotes adhesions...
  19. Mutations in Smooth Muscle Contractile Proteins: Pathways to Vascular Diseases
    Dianna M Milewicz; Fiscal Year: 2013
    ..layers, either embedded between layers of elastin lamellae in large elastic arteries or in a matrix of connective tissue in smaller muscular arteries...
  20. Targeted Delivery of iPS-Endothelial Cells for the Repair of Cardiovascular Injur
    Yiu Fai Chen; Fiscal Year: 2013
    ..In addition, it is expected that the results wll fundamentally advance the field of cell-based therapy by providing a noninvasive and cost effective treatment modality. ..
  21. Phase II Study of Inhales Carbon Monoxide for the Treatment of Idiopathic Pulmona
    Ivan O Rosas; Fiscal Year: 2013
    ..Successful completion of this study will provide the basis for the design of a more definitive phase III clinical trial of low dose inhaled CO in IPF. (End of Abstract) ..
  22. 2013 LAM Symposium
    FRANCIS XAVIER MCCORMACK; Fiscal Year: 2013
    ..lungs and the cystic remodeling of pulmonary parenchyma, including the elaboration of metalloproteinases and connective tissue matrix by LAM cells...
  23. The Role of Basement Membrane Biomechanics in Cancer Cell Invasion
    Aron Parekh; Fiscal Year: 2013
    ..adjacent stromal tissue occurs independent of proteolytic degradation and/or mechanosensing by utilizing the connective tissue component of UBM-BM as a model for the stroma. Dr...
  24. Age related muscle fibrosis via PDGFRa signaling in fibroadipogenic progenitors
    ALISA ANNE MUELLER; Fiscal Year: 2013
    ..in regenerative capabilities, which is associated with fatty infiltration and the deposition of fibrou connective tissue. This fibrotic deposition is particularly harmful because it interferes with propr muscle contraction and ..
  25. Mechanism of Impaired Diabetic Oral Wound Healing
    Dana T Graves; Fiscal Year: 2013
    ..important health issue there have been surprisingly few studies that have examined mechanisms by which oral connective tissue healing is impaired by diabetes...
  26. NMR studies of collagen model peptides and their interactions with collagen recep
    JEAN S BAUM; Fiscal Year: 2012
    ..cancer involve abnormal regulation or reactivity of collagen and certain collagen genetic diseases result in connective tissue disease or aortic aneurism...
  27. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ....
  28. Mechanobiology of Matrix Production by Corneal Fibroblasts
    Jeffrey W Ruberti; Fiscal Year: 2013
    ..Controlled fibroblast directional motility, self-organization and synthetic capacity are fundamental to connective tissue development, growth, remodeling and repair...
  29. Age-related shifts in epithelial lineages and tissue homeostasis in mammary gland
    Mark A Labarge; Fiscal Year: 2013
    ..Some age-associated changes in breast includes increased fat and estrogen receptor expression;decreased connective tissue, numbers of alveoli and overall breast density;changes in collagen-type expression, and discontinuities in ..
  30. Consortium for Translational Research in Marfan Syndrome
    FRANCESCO B RAMIREZ; Fiscal Year: 2013
    Marfan syndrome (MPS) is a common connective tissue disorder caused by mutations In flbrillln-1, the major Structural component of extracellular microfibrils...
  31. Targeting accessory proteins of alpha2C adrenergic receptor in Raynaud Phenomenon
    CATALIN FILIPEANU; Fiscal Year: 2013
    ..Raynaud's Disease (primary or idiopathic) and Raynaud's Syndrome when is associated with another connective tissue disorder like Lupus erythematosus or scleroderma...
  32. Dynamic limits on contraction of gastrointestinal smooth muscle
    MARION JOYCE SIEGMAN; Fiscal Year: 2013
    ..shortening depends on (a) external applied loads and (b) internal resistances provided by the extracellular connective tissue matrix which links smooth muscle cells together and to neighboring cells that are exerting force...
  33. METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWN
    Hideaki Nagase; Fiscal Year: 1993
    The matrix metalloproteinases (MMPs) are a group of zinc enzymes secreted from connective tissue cells and phagocytes...
  34. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    Jennifer Van Eyk; Fiscal Year: 2009
    ..The underlying pathology is diverse and predisposing factors include aortic aneurysms and diseases of the connective tissue. This is a life-threatening event, especially if the dissection is located in the ascending part of the ..
  35. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..The underlying pathology is diverse and predisposing factors include aortic aneurysms and diseases of the connective tissue. This is a life-threatening event, especially if the dissection is located in the ascending part of the ..
  36. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    Scleroderma is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, ..
  37. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2004
    Scleroderma is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, ..
  38. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2003
    Scleroderma is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, ..
  39. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2002
    Scleroderma is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, ..
  40. UV-Induced Collagen Reduction--Treating Skin Scleroderma
    Sewon Kang; Fiscal Year: 2001
    Scleroderma is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, ..
  41. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    ..have been reported between prolapse, joint hypermobility and abdominal striac suggesting a generalized connective tissue defect affecting pelvic organ support, joints and skin. One explanation is a defect in collagen biosynthesis...
  42. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2000
    ..have been reported between prolapse, joint hypermobility and abdominal striac suggesting a generalized connective tissue defect affecting pelvic organ support, joints and skin. One explanation is a defect in collagen biosynthesis...
  43. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2000
    ..have been reported between prolapse, joint hypermobility and abdominal striac suggesting a generalized connective tissue defect affecting pelvic organ support, joints and skin. One explanation is a defect in collagen biosynthesis...
  44. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2001
    ..have been reported between prolapse, joint hypermobility and abdominal striac suggesting a generalized connective tissue defect affecting pelvic organ support, joints and skin. One explanation is a defect in collagen biosynthesis...
  45. Metagenomic Study of the Periodontal Microbiome in Healthy and Diabetic Subjects
    Huiying Li; Fiscal Year: 2013
    ..The host immune response in T2Ds is known to be altered and evidence suggests a dysregulation in connective tissue metabolism...
  46. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..This project will provide an approach that is both compatible with minimally invasive techniques as well as provide a means to reduce post-operative complications while delivering therapeutic agents directly into the aneurysmal tissue. ..
  47. Influence of Innate Immunity on Xenobiotic-Induced Systemic Autoimmunity
    KENNETH MICHAEL POLLARD; Fiscal Year: 2013
    ..mechanisms in silica-induced autoimmunity, the linkage between silicosis and the risk of developing clinical connective tissue diseases such as SLE, suggest that immunological checkpoints in silicosis may contribute to silica-induced ..
  48. Promoting regeneration in muscular dystrophy with adipose derived stem cells.
    Gretchen A Meyer; Fiscal Year: 2013
    ..cells capable of regenerating damaged areas cause extensive replacement of contractile material with connective tissue and fat, decreasing contractile function (1, 2)...
  49. NUCLEAR ACIDIC PROTEIN ANTIGENS IN RHEUMATIC DISEASES
    GORDON SHARP; Fiscal Year: 1990
    ..mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE), and undifferentiated connective tissue disease (UCTD), ..
  50. Abdominal Massage for Postoperative Adhesions and Ileus
    Geoffrey M Bove; Fiscal Year: 2013
    ..Intra-abdominal adhesions (pathological bands of fibrous connective tissue that develop after peritoneal injury) are a leading cause of bowel obstruction, infertility, chronic pain, ..
  51. Nelfinavir in SLE: A Pilot Phase IIa Clinical Trial
    Betty Diamond; Fiscal Year: 2013
    ..Although considered a connective tissue disease, SLE harms a variety of organ systems, including the skin, joints, kidney and brain...
  52. The Epidemiology of Human Chondrogenic Progenitor Cells
    George F Muschler; Fiscal Year: 2013
    ..by defining strategies and principles for selecting and optimizing available sources of chondrogenic connective tissue progenitors (CTP- Cs)...
  53. Micro-Mechanical Role of Hypertension in Intimal Hyperplasia
    Ghassan S Kassab; Fiscal Year: 2013
    ....
  54. Novel Anti-fibrotic Therapy for Diabetic Nephropathy
    Susan C Wright; Fiscal Year: 2013
    ..Two of the most important growth factors driving fibrosis in DN are transforming growth factor-b (TGFb) and connective tissue growth factor (CTGF), which is induced by TGFb...
  55. Development of a Mammalian Model for Rib Repair
    Francesca V Mariani; Fiscal Year: 2013
    ..in the middle of the resection site as well as from the ends, and 3), that the presence of the surrounding connective tissue sheath, or periosteum, is required for complete healing to occur...
  56. Regulated Assembly of the Tendon Extracellular Matrix
    David E Birk; Fiscal Year: 2013
    ..Finally, the underlying molecular pathophysiology of connective tissue disorders, e.g., classic Ehlers Danlos Syndrome, a newly defined collagen XII related myopathy, is addressed...
  57. NEW GENE THERAPY FOR CONNECTIVE TISSUE DISEASES
    Eric Kmiec; Fiscal Year: 1999
    Many inherited connective tissue diseases result from a point mutation or frame-shift mutation...
  58. OSTEOGENESIS IMPERFECTA, AND NITRIC OXIDE THERAPY
    Philip Osdoby; Fiscal Year: 2007
    ..Type I-IV) classes and the three more recent (Type V-VII) novel OI categories demonstrate various skeletal, connective tissue, and neuromuscular manifestations...
  59. Connective tissue and nervous system mechanisms of CAM therapies for low back pai
    Helene M Langevin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stretching of soft tissue (connective tissue and muscle) is an important component of manual (e.g. massage) and movement-based (e.g...
  60. Elastic mechanisms in locomotion
    THOMAS JAY ROBERTS; Fiscal Year: 2013
    ..Changes in the elastic properties of connective tissue elements within muscle are associated with several neuromuscular disorders, aging, and secondary to stroke ..
  61. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2003
    ..According to this hypothesis, the amount of connective tissue in the lung is increased when Pc is elevated for several days...
  62. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..According to this hypothesis, the amount of connective tissue in the lung is increased when Pc is elevated for several days...
  63. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Robert Drake; Fiscal Year: 2001
    ..According to this hypothesis, the amount of connective tissue in the lung is increased when Pc is elevated for several days...
  64. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2002
    ..According to this hypothesis, the amount of connective tissue in the lung is increased when Pc is elevated for several days...
  65. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary Fisher; Fiscal Year: 2009
    ..The long-term goal of the proposed research is to understand molecular basis and functional impact of skin connective tissue aging...
  66. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary J Fisher; Fiscal Year: 2010
    ..The long-term goal of the proposed research is to understand molecular basis and functional impact of skin connective tissue aging...
  67. Transforming Growth Factor-Beta (TGF-b) Signaling in Aged Skin
    Taihao Quan; Fiscal Year: 2013
    ..All of these features are attributable, at least in part, to impairment of the structural integrity of skin connective tissue. The structural component of skin connective tissue is the dermal extracellular matrix (ECM), which is ..
  68. Improved Adventitial Rapamycin Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2013
    ..If these Phase 2 studies are successful, we intend to move into pivotal clinical trials and ultimately seek FDA approval for a novel combination product. ..
  69. Transforming Growth Factor-Beta (TGF-b) Signaling in Photoaged and Chronologicall
    Taihao Quan; Fiscal Year: 2010
    ..All of these features are attributable, at least in part, to impairment of the structural integrity of skin connective tissue. The structural component of skin connective tissue is the dermal extracellular matrix (ECM), which is ..
  70. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ..is largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
  71. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2007
    ..is largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
  72. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2006
    ..is largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
  73. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2009
    ..is largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
  74. CHONDROITIN SULFATE BIOSYNTHESIS CELLULAR LOCALIZATION
    Geetha Sugumaran; Fiscal Year: 1993
    Proteochondroitin sulfate is a major constituent of the cartilage matrix and all other connective tissue. It plays an important role in bone and connective tissue metabolism, wound healing, and in cell interactions...
  75. MICROMECHANICS OF RESPIRATORY MUSCLES
    ALADIN BORIEK; Fiscal Year: 1999
    ..Therefore, the mechanism of force transmissions between the fibers and connective tissue is more complex...
  76. JOINT CONTRACTURE: BIOMECHANICAL-CHEMICAL CORRELATES
    Wayne Akeson; Fiscal Year: 1980
    ..Major changes in the composition of fibrous connective tissue have been demonstrated in experimental joint contractures as a result of immobilization...
  77. Biophysics of Acupuncture:Electrical Properties of Loose CT
    Andrew Ahn; Fiscal Year: 2006
    ..Now, robust evidence linking connective tissue to acupuncture structures has changed the research landscape and offers a new testable hypothesis: ..
  78. Biophysics of Acupuncture: Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2009
    ..Now, robust evidence linking connective tissue to acupuncture structures has changed the research landscape and offers a new testable hypothesis: ..
  79. Biophysics of Acupuncture:Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2007
    ..Now, robust evidence linking connective tissue to acupuncture structures has changed the research landscape and offers a new testable hypothesis: ..
  80. Acupuncture Biophysics--Electrical Properties of CT
    Andrew Ahn; Fiscal Year: 2005
    ..Now, robust evidence linking connective tissue to acupuncture structures has changed the research landscape and offers a new testable hypothesis: ..
  81. CYR61-a novel potential mediator of photoaged human skin
    Taihao Quan; Fiscal Year: 2009
    ..Long-term exposure to UV irradiation damages human skin connective tissue and promotes formation of skin cancer, the most common form of human cancer...
  82. Genetics of Spontaneous Pelvic Organ Prolapse in the Mouse
    Jay Reeder; Fiscal Year: 2009
    ..The condition, which seems to manifest as defects in the supporting connective tissue of the pelvic organs, adversely affects quality of life and is a major health issue for women...
  83. Identification of Enhancers of Therapeutic Exon Skipping for DMD
    M Miceli; Fiscal Year: 2009
    ..topic: 04-AR-106 Cellular, Molecular and Genetic Therapies for Rare Inherited Diseases of Muscle, Skin and Connective Tissue and Bone...
  84. Automated Connective Tissue Torque Sensor
    Robert Davis; Fiscal Year: 2007
    ..project is to establish the usefulness of needle torque measurements for the diagnosis and monitoring of connective tissue pathology associated with chronic musculoskeletal conditions treated by manual therapies...
  85. Identification of Enhancers of Therapeutic Exon Skipping for DMD
    MELISSA JAN SPENCER; Fiscal Year: 2010
    ..topic: 04-AR-106 Cellular, Molecular and Genetic Therapies for Rare Inherited Diseases of Muscle, Skin and Connective Tissue and Bone...
  86. Genetics of Spontaneous Pelvic Organ Prolapse in the Mouse
    Jay E Reeder; Fiscal Year: 2010
    ..The condition, which seems to manifest as defects in the supporting connective tissue of the pelvic organs, adversely affects quality of life and is a major health issue for women...
  87. ACTIVATION OF PERIODONTAL FIBROBLASTS VIA CD40
    Timothy Blieden; Fiscal Year: 2000
    ..This loss of fibroblast activity and, therefore, connective tissue leads to diminished integrity of the periodontium...
  88. ACTIVATION OF PERIODONTAL FIBROBLASTS VIA CD40
    Timothy Blieden; Fiscal Year: 1999
    ..This loss of fibroblast activity and, therefore, connective tissue leads to diminished integrity of the periodontium...
  89. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Thomas Doetschman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cardiac valve thickening is a major cardiovascular manifestation of connective tissue disorders (e.g., Marfan syndrome (MFS) and Ehlers-Danlos syndrome (EDS)), and non-syndromic valvular diseases...
  90. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Simon Conway; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cardiac valve thickening is a major cardiovascular manifestation of connective tissue disorders (e.g., Marfan syndrome (MFS) and Ehlers-Danlos syndrome (EDS)), and non-syndromic valvular diseases...
  91. CONNECTIVE TISSUE ROLE IN URINARY STRESS INCONTINENCE
    J Woessner; Fiscal Year: 1993
    ..to be tested in the present study is that incontinence is related to alterations and weakening of the connective tissue of the vesico-vaginal fascia and other supporting structures: the fascia provides tensile support to the ..
  92. PATHOBIOCHEMISTRY OF EHLERS-DANLOS SYNDROME TYPE 1
    Catherine Stolle; Fiscal Year: 1990
    The Ehlers-Danlos syndrome (EDS) are a group of biochemically and genetically distinct connective tissue disorders characterized by abnormalities of the skin, easy bruisability, and joint hypermobility...
  93. CHONDROITIN SULFATE BIOSYNTHESIS CELLULAR LOCALIZATION
    Geetha Sugumaran; Fiscal Year: 1999
    Proteochondroitin sulfate is a major structural constituent of connective tissue, and occurs as an ubiquitous component of cell surface, where it is considered to be involved in specific cell-cell, cell-matrix and cell-receptor functions...
  94. CHONDROITIN SULFATE BIOSYNTHESIS CELLULAR LOCALIZATION
    Geetha Sugumaran; Fiscal Year: 2001
    Proteochondroitin sulfate is a major structural constituent of connective tissue, and occurs as an ubiquitous component of cell surface, where it is considered to be involved in specific cell-cell, cell-matrix and cell-receptor functions...
  95. CHONDROITIN SULFATE BIOSYNTHESIS CELLULAR LOCALIZATION
    Geetha Sugumaran; Fiscal Year: 2002
    Proteochondroitin sulfate is a major structural constituent of connective tissue, and occurs as an ubiquitous component of cell surface, where it is considered to be involved in specific cell-cell, cell-matrix and cell-receptor functions...
  96. CHONDROITIN SULFATE BIOSYNTHESIS CELLULAR LOCALIZATION
    Geetha Sugumaran; Fiscal Year: 2000
    Proteochondroitin sulfate is a major structural constituent of connective tissue, and occurs as an ubiquitous component of cell surface, where it is considered to be involved in specific cell-cell, cell-matrix and cell-receptor functions...
  97. TRAINING IN CARTILAGE RESEARCH
    KLAUS KUETTNER; Fiscal Year: 2000
    ..grant in osteoarthritis, a significant segment of the faculty is dedicated to basic researching the field of connective tissue and cartilage biochemistry, as it relates to arthritic conditions, especially osteoarthritis (OA)...
  98. TRAINING IN CARTILAGE RESEARCH
    KLAUS KUETTNER; Fiscal Year: 1999
    ..grant in osteoarthritis, a significant segment of the faculty is dedicated to basic researching the field of connective tissue and cartilage biochemistry, as it relates to arthritic conditions, especially osteoarthritis (OA)...