connective tissue

Summary

Summary: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.

Top Publications

  1. pmc Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration
    Malea M Murphy
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Development 138:3625-37. 2011
  2. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
  3. pmc Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
    Boris Hinz
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 180:1340-55. 2012
  4. doi Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
  5. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
  6. ncbi Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
  7. ncbi Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia
    Marc Schmidt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 279:8063-9. 2004
  8. doi Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis
    Efstathios Vassiliadis
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 16:426-33. 2011
  9. doi Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?
    Andres Hilfiker
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Langenbecks Arch Surg 396:489-97. 2011
  10. pmc Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
    Helene M Langevin
    Department of Neurology, Given Building, University of Vermont, Burlington, VT 05405, USA
    BMC Musculoskelet Disord 10:151. 2009

Detail Information

Publications314 found, 100 shown here

  1. pmc Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration
    Malea M Murphy
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Development 138:3625-37. 2011
    ..b>Connective tissue fibroblasts also are likely to play a role in regeneration, as connective tissue fibrosis is a hallmark of ..
  2. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
    ....
  3. pmc Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
    Boris Hinz
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 180:1340-55. 2012
    ..in several fields, such as the following: i) force production by the myofibroblast and mechanisms of connective tissue remodeling; ii) factors controlling the expression of α-smooth muscle actin, the most used marker of ..
  4. doi Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
    ..Its role in aging of the connective tissue has not yet been established, even though the incidence of aging-related disorders in connective tissue-rich ..
  5. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
    ..Zinc (Zn) is an essential trace element and it is abundant in connective tissues, however biological roles of Zn and its transporters in those tissues and cells remain unknown...
  6. ncbi Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
    ..The purpose of this review is to present the current evidence demonstrating that the adventitial fibroblast acts as a key regulator of pulmonary vascular function and structure from the "outside-in."..
  7. ncbi Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia
    Marc Schmidt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 279:8063-9. 2004
    ..with three antibodies directed against different epitopes of the protein consistently show cytoglobin in connective tissue fibroblasts as well as in hepatic stellate cells...
  8. doi Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis
    Efstathios Vassiliadis
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 16:426-33. 2011
    ..The aim of this study was to assess whether levels of a type V collagen fragment, the propeptide CO5-1230, indicate the amount of collagen deposited during liver fibrosis...
  9. doi Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?
    Andres Hilfiker
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Langenbecks Arch Surg 396:489-97. 2011
    ..The purpose of this article is to review the progress of TE technology, focusing on mesenchymal stem cells (MSC) as a cell source for artificial functional tissue...
  10. pmc Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
    Helene M Langevin
    Department of Neurology, Given Building, University of Vermont, Burlington, VT 05405, USA
    BMC Musculoskelet Disord 10:151. 2009
    ..pathogenesis of chronic low back pain (LBP), there have been no previous studies quantitatively evaluating connective tissue structure in this condition...
  11. ncbi Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling
    Boris Hinz
    Laboratory of Cell Biophysics, Swiss Federal Institute of Technology, Bâtiment SG AA B 143, CH 1015 Lausanne, Switzerland
    Thromb Haemost 90:993-1002. 2003
    ..modulation represents a crucial step in granulation tissue contraction and in the production of the connective tissue deformations typical of fibrocontractive diseases...
  12. ncbi Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    J Hepatol 47:699-710. 2007
    b>Connective tissue growth factor (CTGF/CCN2) has been implicated in the pathogenesis of hepatic fibrosis and suggested as a downstream mediator of the fibrogenic master cytokine TGF-beta.
  13. pmc Connective tissue fibroblasts and Tcf4 regulate myogenesis
    Sam J Mathew
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Development 138:371-84. 2011
    Muscle and its connective tissue are intimately linked in the embryo and in the adult, suggesting that interactions between these tissues are crucial for their development...
  14. ncbi Adventitial progenitor cells contribute to arteriosclerosis
    Evelyn Torsney
    Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, SW17 0RE London, UK
    Trends Cardiovasc Med 15:64-8. 2005
    ..Thus, these cells may be a source of smooth muscle cells and might have implications for cellular, genetic, and tissue engineering approaches to vascular disease...
  15. ncbi Pathologic changes in the pericoronal tissues of unerupted third molars
    S Rakprasitkul
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, 6 Yothi Street, Rajthevee, Bangkok 10400, Thailand
    Quintessence Int 32:633-8. 2001
    ..The purpose of this study was to determine whether the incidence of pathologic conditions affecting the pericoronal tissue of unerupted third molars justifies their routine removal...
  16. pmc Extracellular matrix mechanics in lung parenchymal diseases
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Respir Physiol Neurobiol 163:33-43. 2008
    ..Finally, we speculate about the possibility of using targeted tissue engineering to optimize treatment of these two major lung diseases...
  17. doi Pseudotumours associated with metal-on-metal hip resurfacings
    H Pandit
    Nuffield Orthopaedic Centre, Oxford, England
    J Bone Joint Surg Br 90:847-51. 2008
    ..We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause...
  18. ncbi Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms
    Helene M Langevin
    Department of Neurology, Given C423, University of Vermont, Burlington, VT 05405, United States
    Med Hypotheses 68:74-80. 2007
    ..This article presents a new, testable pathophysiological model integrating connective tissue plasticity mechanisms with several well-developed areas of research on cLBP (pain psychology, postural ..
  19. ncbi Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy
    A Mobasheri
    Division of Veterinary Medicine, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom
    Histol Histopathol 24:347-66. 2009
    ....
  20. doi Connective tissue configuration in the human liver hilar region with special reference to the liver capsule and vascular sheath
    Shogo Hayashi
    Aichi Medical University Education Center AMEC, 21 Yazako Karimata, Nagakute, Aichi, 480 1195, Japan
    J Hepatobiliary Pancreat Surg 15:640-7. 2008
    ....
  21. ncbi Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms
    M D Huffman
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Surgery 128:429-38. 2000
    Abdominal aortic aneurysms (AAAs) involve an unfavorable balance between the destruction and the repair of connective tissue proteins...
  22. pmc Chondroitin sulphate inhibits connective tissue mast cells
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, MA 02111, USA
    Br J Pharmacol 131:1039-49. 2000
    ..3. Immunologic stimulation of histamine secretion from rat connective tissue mast cells (CTMC) was also inhibited, but this effect was weaker in umbilical cord-derived human mast cells ..
  23. ncbi Mutable collagenous tissue: overview and biotechnological perspective
    I C Wilkie
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 OBA, Scotland, UK
    Prog Mol Subcell Biol 39:221-50. 2005
    ..that MCT could be a source of, or inspiration for, (1) new pharmacological agents and strategies designed to manipulate therapeutically connective tissue mechanical properties and (2) new composite materials with biomedical applications.
  24. doi Changes in connective tissue in patients with pelvic organ prolapse--a review of the current literature
    M H Kerkhof
    Kennemer Gasthuis Haarlem, Haarlem, The Netherlands
    Int Urogynecol J Pelvic Floor Dysfunct 20:461-74. 2009
    ..In 1996, Jackson presented a hypothesis on pelvic floor connective tissue that tried to explain the development of POP on a molecular level...
  25. doi Use of platelet gel with connective tissue grafts for root coverage: a randomized-controlled trial
    Huseyin Gencay Keceli
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Clin Periodontol 35:255-62. 2008
    ..Aim: The aim of the present study was to compare connective tissue graft (CTG)+PRP with CTG alone in the treatment of gingival recession.
  26. ncbi Structural and mechanical architecture of the intestinal villi and crypts in the rat intestine: integrative reevaluation from ultrastructural analysis
    Yasue Hosoyamada
    Department of Nutrition, Chiba College of Health Science, 2 10 1 Wakaba, Mihama ku, Chiba shi, Chiba, 261 0014, Japan
    Anat Embryol (Berl) 210:1-12. 2005
    ....
  27. ncbi A histologic evaluation of various stages of palatal healing following subepithelial connective tissue grafting procedures: a comparison of eight cases
    Kristi M Soileau
    Department of Oral and Maxillofacial Pathology, Louisiana State University School of Dentistry, New Orleans, LA 70115, USA
    J Periodontol 77:1267-73. 2006
    ..The purpose of this study was to determine whether the length of time between a first procurement and a second would have any bearing on the quality of tissue available for recipient sites...
  28. ncbi Peptides controlling stifness of connective tissue in sea cucumbers
    R Birenheide
    Basic Biology, Faculty of Bioscience and Biotechnology, Tokyo Institue of Technology, Japan
    Biol Bull 194:253-9. 1998
    ..The body wall dermis of sea cucumbers consists of catch connective tissue that is characterized by quick and drastic stiffness changes under nervous control...
  29. ncbi Subepithelial connective tissue grafts in the treatment of multiple recession-type defects
    Luiz Armando Chambrone
    Discipline of Periodontics, Faculty of Dentistry, Methodist University of Sao Paulo, Sao Bernardo do Campo, Brazil
    J Periodontol 77:909-16. 2006
    ..The objective of this study was to evaluate the results obtained with a connective tissue graft placed under a coronally advanced flap for the treatment of multiple gingival recessions.
  30. pmc Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:345-63. 2011
    ..that monkey ONH connective tissues become hypercompliant in early experimental glaucoma (EEG), by using 3-D histomorphometric reconstructions, and to expand the characterization of EEG connective tissue deformation to nine EEG eyes.
  31. ncbi Ontogenetic decline of regenerative ability and the stimulation of human regeneration
    David M Gardiner
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, California 92697, USA
    Rejuvenation Res 8:141-53. 2005
    ..A second lesson is that connective tissue fibroblasts control regeneration, and that the unique regenerative ability of salamanders (the first step of ..
  32. pmc Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 521:299-306. 1999
    ..This suggests an adaptation to acute physical loading also in non-bone-related collagen in humans...
  33. pmc Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue
    Edmar Zanoteli
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochim Biophys Acta 1802:659-72. 2010
    ..Muscle fibers located adjacent to the expanded connective tissue underwent extensive invagination of their sarcolemma, which resulted in the infiltration of the fibers by ..
  34. pmc Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling
    Brian C Tieu
    Department of Biochemistry, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Vasc Res 48:261-72. 2011
    ..Our objective was to explore the contribution of these cells to angiotensin II (Ang II)-induced aortic inflammation and adventitial expansion...
  35. pmc Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular/connective tissue changes in scarring trachoma
    Victor H Hu
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 80:121-30. 2012
    ..This study supports the possibility that the immunofibrogenic response in scarring trachoma is partly stimulated by nonchlamydial bacterial infection, which is characterized by the expression of innate factors...
  36. doi Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration
    Mounir J Haurani
    Department of General Surgery, Hypertension and Vascular Research Division, Room 7044, E and R Building, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 52:143-9. 2008
    ..05). Our data suggest that Nox4 promotes Ang II-induced myofibroblast migration via an H(2)O(2)-dependent pathway. The data also suggest that Nox4 causes feedback inhibition of its own expression in adventitial myofibroblasts...
  37. ncbi A comparative study of the biocompatibility of three root-end filling materials in rat connective tissue
    Shahriar Shahi
    Department of Endodontics, Tabriz Faculty of Dentistry, Azarbaidjan Shargi, Iran
    J Endod 32:776-80. 2006
    The purpose of this study was to compare the biocompatibility of amalgam, gray MTA and white MTA in the connective tissue of rats. We used 45 Sprague-Dawley rats in this study. The rats were divided into three groups...
  38. ncbi Connective tissue growth factor in drug-induced gingival overgrowth
    M I Uzel
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, MA 02118, USA
    J Periodontol 72:921-31. 2001
    ..This study assesses for the presence and localization of connective tissue growth factor (CTGF) in drug-induced gingival overgrowth tissues...
  39. ncbi Immunomodulation of TGF-beta 1 in mdx mouse inhibits connective tissue proliferation in diaphragm but increases inflammatory response: implications for antifibrotic therapy
    Francesca Andreetta
    Department of Neuroimmunology and Neuromuscular Diseases, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Neuroimmunol 175:77-86. 2006
    Irreversible connective tissue proliferation in muscle is a pathological hallmark of Duchenne muscular dystrophy (DMD), a genetic degenerative muscle disease due to lack of the sarcolemmal protein dystrophin...
  40. ncbi Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy
    Guilian Sun
    Department of Pediatrics, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Sci 267:48-56. 2008
    ..In the present study, the immunolocalization and mRNA expression of connective tissue growth factor (CTGF) in muscles from normal and dystrophic human muscles were examined with the goal of ..
  41. doi Zebrafish collagen XII is present in embryonic connective tissue sheaths (fascia) and basement membranes
    Hannah L Bader
    Universite de Lyon, Universite Lyon 1, France
    Matrix Biol 28:32-43. 2009
    ..exhibited a much broader expression pattern than previously thought: it was ubiquitously expressed in the connective tissue sheaths (fascia) that encase the tissues and organs of the body...
  42. ncbi Connective tissue structure of the tree shrew optic nerve and associated ageing changes
    Julie Albon
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 48:2134-44. 2007
    ..To identify the structure and composition of the tree shrew optic nerve to determine its potential as a model for glaucoma...
  43. ncbi Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans
    M A Rossi
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Hypertens 16:1031-41. 1998
    To investigate pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans.
  44. ncbi The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice
    Michael P W Moos
    The Institute for Vascular Medicine, Friedrich Schiller University of Jena, Germany
    Arterioscler Thromb Vasc Biol 25:2386-91. 2005
    ..Cells of adaptive immunity have been implicated in atherogenesis. Though substantial information is available on immune cells in atherosclerotic lesions of the lamina intima, cells in the lamina adventitia have received less attention...
  45. ncbi Reactions of connective tissue to mineral trioxide aggregate and amalgam
    Mehmet Yaltirik
    Faculty of Dentistry, Department of Oral Surgery and Medicine, Istanbul University, Turkey
    J Endod 30:95-9. 2004
    The purpose of this study was to evaluate the subcutaneous connective tissue reactions to ProRoot, mineral trioxide aggregate (MTA; Dentsply), and Oralloy, high-copper amalgam (Coltene)...
  46. ncbi Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice
    Denise M Inman
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    J Comp Neurol 462:431-49. 2003
    ..a unique wound healing response following spinal cord injury in which the lesion site fills in with a connective tissue matrix...
  47. ncbi Tissue displacements during acupuncture using ultrasound elastography techniques
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    Ultrasound Med Biol 30:1173-83. 2004
    Acupuncture needle manipulation has been previously shown to result in measurable changes in connective tissue architecture in animal experiments...
  48. pmc Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes
    Michael D Roberts
    Ocular Biomechanics, Legacy Health System, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:295-307. 2010
    ..To investigate the biomechanical response to IOP elevation of normal monkey eyes using eye-specific, three-dimensional (3-D) finite element (FE) models of the ONH that incorporate lamina cribrosa (LC) microarchitectural information...
  49. ncbi Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?
    Mounir J Haurani
    Henry Ford Hospital, Detroit, Department of General Surgery, MI 48202 2689, USA
    Cardiovasc Res 75:679-89. 2007
    ..We will also survey other signaling pathways involving adventitial NAD(P)H oxidase ultimately leading to changes in vascular phenotype...
  50. pmc The adventitia: a dynamic interface containing resident progenitor cells
    Mark W Majesky
    Seattle Children s Research Institute, Departments of Pediatric, Center for Cardiovascular Biology, and the Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98101, USA
    Arterioscler Thromb Vasc Biol 31:1530-9. 2011
    ..views of the tunica adventitia as a poorly organized layer of vessel wall composed of fibroblasts, connective tissue, and perivascular nerves are undergoing revision...
  51. ncbi No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen
    Am J Physiol Endocrinol Metab 290:E163-E168. 2006
    ..Therefore, there is no effect of menstrual cycle phase, at rest or in response to an acute bout of exercise, on myofibrillar protein synthesis and muscle collagen synthesis in women...
  52. pmc Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-))
    Jennifer Larusso
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Invest Dermatol 129:1388-94. 2009
    Pseudoxanthoma elasticum (PXE) is an autosomal recessive multisystem disorder characterized by ectopic connective tissue mineralization, with clinical manifestations primarily in the skin, eyes, and cardiovascular system...
  53. ncbi Serum collagen type VI and XIV and hyaluronic acid as early indicators for altered connective tissue turnover in alcoholic liver disease
    F Stickel
    I. Department of Medicine, University of Erlangen-Nurnberg, Erlangen, Germany
    Dig Dis Sci 46:2025-32. 2001
    ..The correlation between procollagen-III-N-propeptide and TGF-beta1 emphasizes its role in hepatic fibrogenesis...
  54. ncbi Connective tissue metabolism and gingival overgrowth
    P C Trackman
    Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Division of Oral Biology, Boston, MA 02118, USA
    Crit Rev Oral Biol Med 15:165-75. 2004
    ....
  55. ncbi Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
    H M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    FASEB J 15:2275-82. 2001
    ..We hypothesize that 1) needle grasp is due to mechanical coupling between the needle and connective tissue with winding of tissue around the needle during needle rotation and 2) needle manipulation transmits a ..
  56. doi Influence of laser photobiomodulation upon connective tissue remodeling during wound healing
    Alena P Medrado
    Laboratory of Experimental Pathology, Oswaldo Cruz Foundation, Rua Waldemar Falcão, 121, Salvador, Bahia 40 296 710, Brazil
    J Photochem Photobiol B 92:144-52. 2008
    ..Thus, laser photobiomodulation was able to induce several modifications during the cutaneous healing process, especially in favoring newly-formed collagen fibers to be better organized and compactedly disposed...
  57. ncbi Leukotriene formation by mouse connective tissue mast cells
    B A Jakschik
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110
    Eicosanoids 5:39-43. 1992
    ..Western blot analysis confirmed the presence of 5-lipoxygenase in connective tissue mast cells...
  58. pmc Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma
    Michael D Roberts
    Ocular Biomechanics Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 50:681-90. 2009
    To characterize the trabeculated connective tissue microarchitecture of the lamina cribrosa (LC) in terms of total connective tissue volume (CTV), connective tissue volume fraction (CTVF), predominant beam orientation, and material ..
  59. doi Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells
    Ayuko Hoshino
    Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    Biochem Biophys Res Commun 368:305-10. 2008
    ..These findings demonstrate that human vascular adventitia contains MPCs, and that hVAFs may be an ideal source for further experiments on stem cell biology and tissue engineering...
  60. ncbi Estimation of Young's modulus and Poisson's ratio of soft tissue from indentation using two different-sized indentors: finite element analysis of the finite deformation effect
    A P C Choi
    Rehabilitation Engineering Centre, Kowloon Polytechnic University, Kowloon, China
    Med Biol Eng Comput 43:258-64. 2005
    ..After the finite deformation effect of indentation was considered, the error of the calculated Young's modulus could be controlled within 5% (a/h = 1) and 2% (a/h = 2) for deformation up to 10%...
  61. ncbi Treatment of gingival recession: comparison of two techniques of subepithelial connective tissue graft
    Tolga F Tozum
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Periodontol 76:1842-8. 2005
    ..This clinical study was conducted to examine the coverage of gingival recession defects, where two different subepithelial connective tissue graft (SCTG) techniques (Langer and Langer and modified tunnel) were used.
  62. ncbi Tissue response to a new methacrylate-based root canal sealer: preliminary observations in the subcutaneous connective tissue of rats
    Osvaldo Zmener
    Department of Adult Dental Care, Section of Endodontics, Faculty of Odontology, University of Buenos Aires, Republica Argentina
    J Endod 30:348-51. 2004
    ..Silicone tubes filled with EndoRez, a methacrylate-based root canal sealer, were implanted in the subcutaneous connective tissue of the rat...
  63. ncbi Endothelin-1 expression in vascular adventitial fibroblasts
    Sheng Jun An
    Dept of Community Health Sciences, Faculty of Applied Health Sciences, Brock Univ, St Catharines, ON, Canada L2S 3Y6
    Am J Physiol Heart Circ Physiol 290:H700-8. 2006
    ..The results demonstrate that vascular adventitial fibroblasts are able to synthesize and release ET-1 in response to ANG II...
  64. ncbi Initial characterization of the microenvironment that regulates connective tissue degradation in amniochorion during normal human labor
    Guadalupe Estrada-Gutierrez
    Research Direction, Instituto Nacional de Perinatologia, Mexico City, Mexico
    Matrix Biol 24:306-12. 2005
    ..Initial characterization of the effect of different blood compartments on connective tissue degradation in amniochorion during human labor was explored...
  65. ncbi Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling
    C D Jordan
    Department of Pathology, University of Washington, USA
    J Musculoskelet Neuronal Interact 6:366-7. 2006
  66. ncbi An ultrastructural study of connective tissue in mollusc integument: II. Gastropoda
    A Bairati
    Dipartimento di Fisiologia e Biochimica Generali, Sezione di Istologia e Anatomia Umana, Universita degli Studi di Milano, Italy
    Tissue Cell 33:426-38. 2001
    We studied the ultrastructure of the subepidermal connective tissue (SEC) in different zones of the integument in terrestrial, marine and freshwater gastropods (eight species)...
  67. pmc CAUDLES-EF: carotid automated ultrasound double line extraction system using edge flow
    Filippo Molinari
    Biolab Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129, Torino, Italy
    J Digit Imaging 24:1059-77. 2011
    ..Regarding the Figure of Merit (FoM), CALEXia and CULEXsa showed the values of 84.7% and 91.5%, respectively, while our new approach, CAUDLES-EF, performed the best at 94.8%, showing a good improvement compared to previous methods...
  68. ncbi Single-tooth replacement by immediate implant and connective tissue graft: a 1-9-year clinical evaluation
    Andrea E Bianchi
    Department of Periodontology and Implantology, Istituto Stomatologico Italiano, Milan, Italy
    Clin Oral Implants Res 15:269-77. 2004
    ..the long-lasting efficacy of a combined surgical protocol, using immediate implant and subepithelial connective tissue graft for single-tooth replacement...
  69. ncbi Short and long-term results of connective tissue manipulation and combined ultrasound therapy in patients with fibromyalgia
    Ilkim Citak-Karakaya
    Mugla University, Mugla School of Health Sciences, Mugla, Turkey
    J Manipulative Physiol Ther 29:524-8. 2006
    The aim of the study was to evaluate the short-term and 1-year follow-up results of connective tissue manipulation and combined ultrasound (US) therapy (US and high-voltage pulsed galvanic stimulation) in terms of pain, complaint of ..
  70. ncbi Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms
    Federico E Parodi
    Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Vasc Surg 20:360-8. 2006
    ..The possibility that dietary ingestion of curcumin may have a beneficial effect in degenerative aortic aneurysms warrants further consideration...
  71. ncbi The echinoderm collagen fibril: a hero in the connective tissue research of the 1990s
    Greg Szulgit
    Department of Biology, McDaniel College, 2 College Hill, Westminster, MD 21157, USA
    Bioessays 29:645-53. 2007
    ..This information will be fundamental in understanding what holds collagenous tissues together at the fibrillar level, and could have important implications for people with Ehlers-Danlos syndrome...
  72. pmc Force transmission between synergistic skeletal muscles through connective tissue linkages
    Huub Maas
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
    J Biomed Biotechnol 2010:575672. 2010
    ..Future studies are needed to investigate the importance of intermuscular force transmission during movement in health and disease...
  73. ncbi Contractile and connective tissue protein content of human skeletal muscle: effects of 35 and 90 days of simulated microgravity and exercise countermeasures
    Jacob M Haus
    Human Performance Laboratory, Ball State Univ, Muncie, IN 47306, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1722-7. 2007
    ..muscles are able to maintain the concentrations of the general protein pools and the main contractile and connective tissue elements...
  74. ncbi Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1
    Darcey Klaahsen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 18:719-26. 2007
    ..The results of this study merit the further investigation of the role of reactive oxidative species with regard to Nfkappab1 in the copper deficient rat heart...
  75. ncbi Water transport and IIF parameters for a connective tissue equivalent
    Saravana Kumar Balasubramanian
    Department of Mechanical Engineering, University of Minnesota, 111 Church Street SE, Minneapolis, MN 55455, USA
    Cryobiology 52:62-73. 2006
    ..The observed biophysics seems to indicate that cell-cell and cell-matrix interactions play a major role in ice propagation in TEs...
  76. ncbi Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia
    Pattaratida Sa-nguanmoo
    Center of Excellence in Viral Hepatitis Research, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University
    J Med Assoc Thai 90:251-7. 2007
    b>Connective tissue growth factor (CTGF) has been proposed to play a key role in the pathogenesis of hepatic fibrosis in biliary atresia (BA)...
  77. ncbi Zosteriform connective tissue nevus: a case report
    Shih Wei Yeh
    Department of Dermatology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Int J Dermatol 42:720-2. 2003
    Because of its distinctive clinical features and histopathological characteristics, zosteriform connective tissue nevus is considered a separate entity from other connective tissue nevi...
  78. ncbi The connective tissue and glial framework in the optic nerve head of the normal human eye: light and scanning electron microscopic studies
    Tokuhide Oyama
    Division of Microscopic Anatomy and Bio imaging, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arch Histol Cytol 69:341-56. 2006
    The arrangement of connective tissue components (i.e...
  79. ncbi Epimuscular myofascial force transmission between antagonistic and synergistic muscles can explain movement limitation in spastic paresis
    Peter A Huijing
    Instituut voor Fundamentele en Klinische Bewegingswetenschappen, Faculteit Bewegingswetenschappen, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    J Electromyogr Kinesiol 17:708-24. 2007
    ....
  80. ncbi Diagnostic value of serum markers of connective tissue turnover for predicting histological staging and grading in patients with chronic hepatitis C
    Y Murawaki
    Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan
    J Gastroenterol 36:399-406. 2001
    ..CONCLUSIONS: These serum fibrotic markers, especially the serum HA test, would be clinically useful for assessing staging and grading in patients with chronic hepatitis C...
  81. pmc Light and scanning electron microscopic study on the lingual papillae and their connective tissue cores of the Cape hyrax Procavia capensis
    Ken Yoshimura
    Department of Anatomy, Faculty of Life Dentistry, The Nippon Dental University at Niigata, Niigata, Japan
    J Anat 213:573-82. 2008
    We examined the epithelial surface and connective tissue cores (CTCs) of each lingual papilla on the Paenungulata, Cape hyrax (Procavia capensis), by scanning electron microscopy and light microscopy...
  82. ncbi Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate
    Roberto Holland
    Department of Restorative Dentistry, Faculty of Dentistry of Aracatuba, UNESP, Aracatuba, SP, Brazil
    Braz Dent J 13:23-6. 2002
    The purpose of this paper was to study the reaction of rat subcutaneous connective tissue to the implantation of dentin tubes filled with white mineral trioxide aggregate (MTA), a material that will be marketed...
  83. ncbi The fine connective tissue architecture of the human ligamentum nuchae
    G M Johnson
    Department of Anatomy and Structural Biology, University of Otago School of Physiotherapy, Dunedin, New Zealand
    Spine (Phila Pa 1976) 25:5-9. 2000
    ..An anatomic study of the posterior midline structures of the cervical spine was performed using a new sheet-plastination (E12) technique in conjunction with gross anatomic dissection...
  84. ncbi Comparison of 2 techniques of subepithelial connective tissue graft in the treatment of gingival recessions
    G Cordioli
    Department of Periodontology, University of Padova, Institute of Clinical Dentistry, Italy
    J Periodontol 72:1470-6. 2001
    BACKGROUND: The clinical outcome of connective tissue grafts in the treatment of gingival recessions has been documented in numerous studies...
  85. doi PLGA nanofiber-coated silk microfibrous scaffold for connective tissue engineering
    Sambit Sahoo
    NUS Tissue Engineering Program, National University of Singapore, Singapore
    J Biomed Mater Res B Appl Biomater 95:19-28. 2010
    ..Although PLGA-based hybrid scaffolds have earlier been proposed for dense connective tissue engineering, rapid biodegradation of PLGA was a drawback...
  86. doi A novel stiffening factor inducing the stiffest state of holothurian catch connective tissue
    Akira Yamada
    Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, Hyogo 651 2492, Japan
    J Exp Biol 213:3416-22. 2010
    The dermis of sea cucumbers is a catch connective tissue or mutable collagenous tissue that shows large changes in stiffness...
  87. pmc Fibroblast cytoskeletal remodeling contributes to connective tissue tension
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 226:1166-75. 2011
    The visco-elastic behavior of connective tissue is generally attributed to the material properties of the extracellular matrix rather than cellular activity...
  88. pmc Application of WGA lectin staining for visualization of the connective tissue in skeletal muscle, bone, and ligament/tendon studies
    Tatiana Y Kostrominova
    Department of Anatomy and Cell Biology, Indiana University School of Medicine Northwest, Gary, Indiana 46409 1008
    Microsc Res Tech 74:18-22. 2011
    ..Often in skeletal muscle research, immunostaining with antibodies against connective tissue or plasma membrane proteins (collagen 1, laminin, and caveolin 3) are used for this purpose...
  89. ncbi Basaloid/follicular hyperplasia overlying connective tissue/mesenchymal hamartomas simulating basal cell carcinomas
    M E Stashower
    Department of Dermatology, National Naval Medical Center, Bethesda, Maryland, USA
    J Am Acad Dermatol 45:886-91. 2001
    ..antibodies, which may suggest differences in pathogenesis, were different in basaloid hyperplasia overlying connective tissue/mesenchymal hamartomas and BCC...
  90. ncbi Posterior subtenon triamcinolone acetonide for refractory diabetic macular edema
    Sophie J Bakri
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 4195, USA
    Am J Ophthalmol 139:290-4. 2005
    ..To evaluate posterior subtenon injection of triamcinolone acetonide for refractory diabetic macular edema (DME)...
  91. ncbi Nipple connective tissue and its development: insights from the K14-PTHrP mouse
    Arman Abdalkhani
    Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405 4401, USA
    Mech Dev 115:63-77. 2002
    ..In this report, we characterize the morphology and processes that influence the development of nipple connective tissue. The connective tissue of the nipple displayed increased levels of proteoglycans, and collagen bundles with ..
  92. ncbi High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Hum Mutat 19:641-55. 2002
    ..found in patients suffering premature thrombosis and homocystinuric levels of Hcy but lacking any of the connective tissue disorders typical of homocystinuria due to CBS deficiency...
  93. pmc Comparative glycomics of connective tissue glycosaminoglycans
    Alicia M Hitchcock
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Proteomics 8:1384-97. 2008
    ..The results provide important new information on the changes to the expression of CS GAG chains during disease and development...
  94. ncbi Exercise-dependent IGF-I, IGFBPs, and type I collagen changes in human peritendinous connective tissue determined by microdialysis
    Jens L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 102:214-20. 2007
    ..The local increased collagen synthesis was preceded by an elevation of local concentration of IGFBP-4, suggesting that IGFBP-4 may have a key role in the IGF-axis effect on the human collagen synthesis in vivo...
  95. ncbi Root coverage of advanced gingival recession: a comparative study between acellular dermal matrix allograft and subepithelial connective tissue grafts
    Haim Tal
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontol 73:1405-11. 2002
    Acellular dermal matrix allograft (ADMA) has successfully been applied as a substitute for free connective tissue grafts (CTG) in various periodontal procedures, including root coverage...
  96. ncbi Connective tissue graft to correct peri-implant soft tissue margin: A clinical report
    Jamil Awad Shibli
    Department of Periodontology, Dental Research Division, Guarulhos University, Sao Paulo, Brazil
    J Prosthet Dent 91:119-22. 2004
    This clinical report describes the use of a subepithelial connective tissue graft to recontour a soft tissue margin discrepancy for a single-implant crown in the anterior maxilla...
  97. ncbi Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils
    L Y Sakai
    Shriners Hospital for Crippled Children, Portland, Oregon 97201
    J Biol Chem 266:14763-70. 1991
    Fibrillin, a connective tissue macromolecule (Mr = 350,000) which is normally insoluble in its tissue form, has been purified from the medium of human skin fibroblast and ligament cells in culture...
  98. ncbi Growth hormone and connective tissue in exercise
    S Doessing
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Copenhagen NV, Denmark
    Scand J Med Sci Sports 15:202-10. 2005
    ..a possible anabolic effect on myofibrillar muscle protein, we suggest a role for GH as an anabolic agent in connective tissue in human skeletal muscle and tendon...
  99. ncbi Vitrectomy with or without arteriovenous adventitial sheathotomy for macular edema associated with branch retinal vein occlusion
    Shuichi Yamamoto
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba
    Am J Ophthalmol 138:907-14. 2004
    ..compare the results of vitrectomy with or without arteriovenous (AV) crossing sheathotomy for macular edema associated with branch retinal vein occlusion (BRVO)...
  100. ncbi [Role of pericytes in mechanism of vessel neovascularisation in the regenerating connective tissue]
    V V Banin
    Department of Morphology, Russian State Medical University, Moscow
    Morfologiia 125:45-50. 2004
    ..electron microscopic study of cellular interrelations in the process of capillary growth in the regenerating connective tissue. The study was performed in 28 albino rats which have been implanted with different polymer nets in the ..
  101. doi Application of exogenous enzymes to beef muscle of high and low-connective tissue
    G A Sullivan
    Department of Animal Science, University of Nebraska, A213 AnS, Box 830908, Lincoln, NE 68583 0908, USA
    Meat Sci 85:730-4. 2010
    ..Sensory evaluation showed improvement (P<0.0009) for tenderness and connective tissue component and all except ginger had a lower shear force than the control (P<0.003)...

Research Grants77

  1. METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWN
    Hideaki Nagase; Fiscal Year: 1993
    The matrix metalloproteinases (MMPs) are a group of zinc enzymes secreted from connective tissue cells and phagocytes...
  2. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    Scleroderma is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, ..
  3. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    ..have been reported between prolapse, joint hypermobility and abdominal striac suggesting a generalized connective tissue defect affecting pelvic organ support, joints and skin. One explanation is a defect in collagen biosynthesis...
  4. OSTEOGENESIS IMPERFECTA, AND NITRIC OXIDE THERAPY
    Philip Osdoby; Fiscal Year: 2007
    ..Type I-IV) classes and the three more recent (Type V-VII) novel OI categories demonstrate various skeletal, connective tissue, and neuromuscular manifestations...
  5. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Robert Drake; Fiscal Year: 2001
    ..According to this hypothesis, the amount of connective tissue in the lung is increased when Pc is elevated for several days...
  6. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..According to this hypothesis, the amount of connective tissue in the lung is increased when Pc is elevated for several days...
  7. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary J Fisher; Fiscal Year: 2010
    The long-term goal of the proposed research is to understand molecular basis and functional impact of skin connective tissue aging. Skin, like all human organs, undergoes deleterious alterations as a consequence of the passage of time...
  8. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary Fisher; Fiscal Year: 2009
    The long-term goal of the proposed research is to understand molecular basis and functional impact of skin connective tissue aging. Skin, like all human organs, undergoes deleterious alterations as a consequence of the passage of time...
  9. Transforming Growth Factor-Beta (TGF-b) Signaling in Photoaged and Chronologicall
    Taihao Quan; Fiscal Year: 2010
    ..All of these features are attributable, at least in part, to impairment of the structural integrity of skin connective tissue. The structural component of skin connective tissue is the dermal extracellular matrix (ECM), which is ..
  10. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ..is largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
  11. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2009
    ..is largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
  12. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2007
    ..is largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
  13. Biophysics of Acupuncture:Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2007
    ..Now, robust evidence linking connective tissue to acupuncture structures has changed the research landscape and offers a new testable hypothesis: ..
  14. CYR61-a novel potential mediator of photoaged human skin
    Taihao Quan; Fiscal Year: 2009
    ..Long-term exposure to UV irradiation damages human skin connective tissue and promotes formation of skin cancer, the most common form of human cancer...
  15. Automated Connective Tissue Torque Sensor
    Robert Davis; Fiscal Year: 2007
    ..project is to establish the usefulness of needle torque measurements for the diagnosis and monitoring of connective tissue pathology associated with chronic musculoskeletal conditions treated by manual therapies...
  16. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Thomas Doetschman; Fiscal Year: 2010
    Cardiac valve thickening is a major cardiovascular manifestation of connective tissue disorders (e.g., Marfan syndrome (MFS) and Ehlers-Danlos syndrome (EDS)), and non-syndromic valvular diseases...
  17. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Simon Conway; Fiscal Year: 2009
    Cardiac valve thickening is a major cardiovascular manifestation of connective tissue disorders (e.g., Marfan syndrome (MFS) and Ehlers-Danlos syndrome (EDS)), and non-syndromic valvular diseases...
  18. CHONDROITIN SULFATE BIOSYNTHESIS CELLULAR LOCALIZATION
    Geetha Sugumaran; Fiscal Year: 2002
    Proteochondroitin sulfate is a major structural constituent of connective tissue, and occurs as an ubiquitous component of cell surface, where it is considered to be involved in specific cell-cell, cell-matrix and cell-receptor functions...
  19. ROLE OF CONNECTIVE TISSUE GEOMETRY IN ACUPUNCTURE
    HELEN BUETTNER; Fiscal Year: 2007
    ..Recent evidence suggests that the connective tissue in the vicinity of an acupuncture point plays a critical role in the local tissue response to in vivo ..
  20. Novel Therapies and Biomarkers for the Mucopolysaccharidoses
    CALOGERA MARIA SIMONARO; Fiscal Year: 2010
    The mucopolysaccharidoses (MPS) are inherited, connective tissue disorders that result from the deficient activities of specific lysosomal enzymes required for glycosaminoglycan (GAG) degradation...
  21. CYR61-a novel potential mediator of photoaged human skin
    Taihao Quan; Fiscal Year: 2010
    Ultraviolet (UV) irradiation from the sun damages human skin connective tissue and causes premature skin aging (photoaging). Photoaging exists in nearly all adult individuals and is therefore a significant public health concern...
  22. CYR61-a novel potential mediator of photoaged human skin
    Taihao Quan; Fiscal Year: 2007
    Ultraviolet (UV) irradiation from the sun damages human skin connective tissue and causes premature skin aging (photoaging). Photoaging exists in nearly all adult individuals and is therefore a significant public health concern...
  23. The Cellular and Molecular Basis of FOP Lesions
    Eileen M Shore; Fiscal Year: 2010
    ..model in which an inflammatory microenvironment caused by soft tissue injury mobilizes resident Tie2+ connective tissue progenitor cells of vascular origin...
  24. The Cellular and Molecular Basis of FOP Lesions
    Eileen M Shore; Fiscal Year: 2010
    ..model in which an inflammatory microenvironment caused by soft tissue injury mobilizes resident Tie2+ connective tissue progenitor cells of vascular origin...