Genomes and Genes
Summary: Collections of differentiated CELLS, such as EPITHELIUM; CONNECTIVE TISSUE; MUSCLES; and NERVE TISSUE. Tissues are cooperatively arranged to form organs with specialized functions such as RESPIRATION; DIGESTION; REPRODUCTION; MOVEMENT; and others.
Publications1067 found, 100 shown here
- Pharmacological and toxicological effects of chronic porcine growth hormone administration in dogsS Prahalada
Department of Safety Assessment, Merck Research Laboratories MRL, West Point, Pennsylvania 19486, USA
Toxicol Pathol 26:185-200. 1998..Necropsies were performed, organs weighed, and tissues were fixed and processed for light microscopic examination...
- Systemic proliferative changes and clinical signs in cynomolgus monkeys administered a recombinant derivative of human epidermal growth factorJ F Reindel
Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
Toxicol Pathol 29:159-73. 2001..This report documents clinical findings and structural effects in the remaining epithelium-containing tissues of these animals...
- Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytesG Muller
Hoechst AG Frankfurt, Germany
Horm Metab Res 28:469-87. 1996..of sulfonylureas as deduced from the ranking in vivo between glimepiride and glibenclamide directly on peripheral tissues would imply a similar ranking between the two drugs in glucose utilizing processes in isolated muscle and fat ..
- Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiolsX Liu
Department of Pharmacology, University of Glasgow
Br J Pharmacol 111:1287-95. 1994..3 mM), inhibited NANC relaxation and this was prevented by pretreating tissues with L-cysteine (3 mM), L-glutathione (3 mM) or dithiothreitol (3 mM)...
- High-performance liquid chromatographic method for the simultaneous detection of malonaldehyde, acetaldehyde, formaldehyde, acetone and propionaldehyde to monitor the oxidative stress in heartG A Cordis
University of Connecticut School of Medicine, Farmington 06030-1110
J Chromatogr A 661:181-91. 1994..acid (TBA) reactive products remains the method of choice to study the development of oxidative stress in tissues. However, MDA estimation by TBA reactive products is non-specific and often gives erroneous results...
- Responses of the red blood cells from two high-energy-demand teleosts, yellowfin tuna (Thunnus albacares) and skipjack tuna (Katsuwonus pelamis), to catecholaminesT E Lowe
Joint Institute for Marine and Atmospheric Research, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu 96822, USA
J Comp Physiol B 168:405-18. 1998..Tuna physiology and behavior dictate exceptionally high rates of O2 delivery to the tissues often under adverse conditions, but especially during recovery from exhaustive exercise when plasma pH may be ..
- Effects of macrophage depletion on the induction of histidine decarboxylase by lipopolysaccharide, interleukin 1 and tumour necrosis factorY Endo
Department of Pharmacology, School of Dentistry, Tohoku University, Sendai, Japan
Br J Pharmacol 114:187-93. 1995..and tumour necrosis factor (TNF) induces histidine decarboxylase (HDC), the enzyme forming histamine, in various tissues such as liver, lung, spleen and bone marrow, but not in the blood...
- Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory proteinP R Manna
Department of Physiology, Institute of Biomedicine, University of Turku, Finland
Endocrinology 140:1739-51. 1999..StAR protein expression is restricted to steroidogenic tissues, and it responds to hormonal stimulation through different second messenger pathways...
- Pharmacological activity of (-)-discretamine, a novel vascular alpha-adrenoceptor and 5-hydroxytryptamine receptor antagonist, isolated from Fissistigma glaucescensF N Ko
Pharmacological Institute, College of Medicine, National Taiwan University, Taipei
Br J Pharmacol 110:882-8. 1993..discretamine, isolated from Fissistigma glaucescens, was determined in rat isolated thoracic aorta, cardiac tissues and ventricular myocytes and guinea-pig isolated trachea. 2...
- Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responsesC E Bryant
William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
Br J Pharmacol 114:1673-9. 1995..4. The relaxations of isolated rings of rat thoracic aorta induced by acetylcholine were inhibited in tissues prepared from rats treated chronically with L-NAME (n = 5-7). Acute administration of L-NAME (0...
- Differential sensitivity of basal and acetylcholine-stimulated activity of nitric oxide to destruction by superoxide anion in rat aortaK B Mian
Clinical Research Initiative on Heart Failure, University of Glasgow
Br J Pharmacol 115:993-1000. 1995..from removal of the tonic vasodilator action of basally-produced NO by superoxide anion, since it was blocked in tissues treated with SOD (250 u ml-1), NG-monomethyl-L-arginine (L-NMMA, 30 microM) or L-NOARG (30 microM). Pyrogallol (0...
- [A study of the literature on the concentrations of arsenic, lead, cadmium and mercury in body fluids and tissues to define normal values and detection of overload. 1. Description of analytical methods and arsenic]P Baron
, Abt Allgemeine und Umwelthygiene
Zentralbl Bakteriol Mikrobiol Hyg B 186:289-310. 1988..When detected levels of a given metal are in a range held to be normal, exclusion of toxic effects and poisoning requires additional consideration of clinical findings...
- Characterization of the interaction between muscarinic M2 receptors and beta-adrenoceptor subtypes in guinea-pig isolated ileumH Reddy
Syntex Discovery Research, Institute of Pharmacology, Palo Alto, CA 94303
Br J Pharmacol 114:49-56. 1995..Selective M3 receptor alkylation was achieved by pretreatment of tissues with 4-DAMP mustard (40 nM), in the presence of methoctramine (1 micro M; to protect M2 receptors)...
- Applications of 99mTc-sestamibi in oncologyL Maffioli
Divison of Nuclear Medicine, National Cancer Institute, Milan, Italy
Tumori 82:12-21. 1996..This explains the initial biodistribution of 99mTc-SestaMIBI to tissues with negative plasma membrane potentials and with relatively high mitochondrial content (like heart, liver, ..
- Preclinical development strategies for novel gene therapeutic productsA M Pilaro
United States Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Therapeutics Research and Review, Rockville, Maryland 20852, USA
Toxicol Pathol 27:4-7. 1999..viruses, and herpesviruses and plasmid DNA, are used to transfer foreign genetic material into patients' cells or tissues. Developing a toxicology program to determine the safety of these agents, therefore, requires a modified approach ..
- Toxicological evaluation of u-hEGFR Maraschin
Istituto di Ricerche Biomediche Antoine Marxer, RBM S p A Ivrea Torino, Italy
Toxicol Pathol 23:356-66. 1995..e., epithelial hyperplasia) in a wide range of tissues and organs, at all doses...
- Antioxidant defenses and lipid peroxidation damage in estivating toads, Scaphiopus couchiiJ E Grundy
Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
J Comp Physiol B 168:132-42. 1998..Activities of many enzymes, particularly the glutathione-linked enzymes, were significantly lower in tissues of estivating toads than in awake toads...
- [Congenital atrioventricular block]R Grolleau
Service de cardiologie A, , Montpellier
Arch Mal Coeur Vaiss 92:47-55. 1999..Anti Ro/SS-A and La/SS-B antibodies cross into the foetal circulation and cause inflammation of the conduction tissues but the causal mechanism is not known...
- Lipoprotein lipase activity and its relationship to high milk fat transfer during lactation in grey sealsS J Iverson
Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Halifax, Canada
J Comp Physiol B 165:384-95. 1995Lipoprotein lipase regulates the hydrolysis of circulating triglyceride and the uptake of fatty acids by most tissues, including the mammary gland and adipose tissue...
- Gene sharing in lens and cornea: facts and implicationsJ Piatigorsky
Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 2730, USA
Prog Retin Eye Res 17:145-74. 1998..identical gene specifying a stress protein or a metabolic enzyme which has non-refractive functions in numerous tissues. This double use of a distinct protein has been called gene sharing...
- Hyaline droplet accumulation in rodent kidney proximal tubules: an association with histiocytic sarcomaG C Hard
MRC Toxicology Unit, Carshalton, Surrey, United Kingdom
Toxicol Pathol 19:88-97. 1991..The tissues of 101 Sprague-Dawley, 25 Osborne-Mendel, and 70 Fischer 344 rats and 96 B6C3F1 mice were examined...
- Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig tracheaN Watson
Department of Thoracic Medicine, National Heart and Lung Institute, London
Br J Pharmacol 109:751-9. 1993..When applied to the tissues during nerve stimulation,GR71251 caused a small, but significant, inhibition of PGS-induced contractions during ..
- Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element studyJ C Lotz
Department of Orthopaedic Surgery, University of California, San Francisco, California, USA
Spine (Phila Pa 1976) 23:2493-506. 1998..in hydration and stress have been associated with changes in disc cell activity in vitro and in other collagenous tissues in vivo. METHODS: Mouse tail discs were loaded in vivo with an external compression device...
- Involvement of apamin-sensitive K+ channels in antigen-induced spasm of guinea-pig isolated tracheaH Yamauchi
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
Br J Pharmacol 112:958-62. 1994..3. OA (10, 100 or 1000 ng ml-1) was incubated with minced lung tissues from the same animals for 15 min in the presence and absence of K+ channel blockers, and released histamine and ..
- The interaction of the NK1 receptor antagonist CP-96,345 with L-type calcium channels and its functional consequencesS Guard
Parke Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge
Br J Pharmacol 110:385-91. 1993..In isolated peripheral tissues containing tachykinin receptors, the effects of (+/-)-CP-96,345 have been compared with those of diltiazem. 2...
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from frog skeletal muscle: purification, kinetics and immunological propertiesM Pyko
Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium
J Comp Physiol B 163:89-98. 1993..is the most potent activator of 6-phosphofructo-1-kinase, a key regulatory enzyme of glycolysis in animal tissues. This study was prompted by the finding that the content of fructose 2,6-bisphosphate in frog skeletal muscle was ..
- Antiepileptic drugs in the management of cluster headache and trigeminal neuralgiaT D Rozen
Department of Neurology, Jefferson Medical College, Thomas Jefferson University Hospital, Jefferson Headache Center, Philadelphia, PA, USA
Headache 41:S25-32. 2001..and lasts 15 to 180 minutes; the pain of trigeminal neuralgia lasts just seconds and is usually limited to the tissues overlying the maxillary and mandibular divisions of the trigeminal nerve...
- [Increased phosphorylations of proteins involved in the expression of the physiologic response of platelets in SHR rats]S Koutouzov
, INSERM U 7, , Paris, France
Arch Mal Coeur Vaiss 83:1317-20. 1990In primary hypertension, phospholipase C (PLC) is hypersensitive in several target tissues (platelets, vascular smooth muscle cells, aortic fibroblasts)...
- Inflammatory cytokines in the herniated disc of the lumbar spineH Takahashi
First Department of Orthopaedic Surgery, Tokyo, Japan
Spine (Phila Pa 1976) 21:218-24. 1996STUDY DESIGN: Tissues in the area of herniated lumbar discs were examined for inflammatory cytokines to elucidate the causes of sciatic pain in lumbar disc herniation...
- [Trends of tissue hypoxia following chemotherapy of acute malaria in mice]A Hioki
Department of Parasitology, Gifu University School of Medicine
Kansenshogaku Zasshi 65:1508-13. 1991..Adenosine triphosphate concentration in liver tissues, however, began to increase on day 1 of treatment...
- Reversal of the suppressed kidney renin level in the hypertensive transgenic rat TGR(mRen-2)27 by angiotensin converting enzyme inhibitionY Tokita
Department of Medicine, Medical College of Ohio, Toledo, USA
Am J Hypertens 8:1031-9. 1995..of the angiotensin converting enzyme (ACE) inhibitor, perindopril on the renin-angiotensin system in plasma and tissues (adrenal gland and kidney), and the effect of mouse renin antibody on plasma and tissue renin activity before and ..
- Identification of four ovarian receptor proteins that bind vitellogenin but not other homologous plasma lipoproteins in the rainbow trout, Oncorhynchus mykissC R Tyler
Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UK
J Comp Physiol B 166:11-20. 1996Membrane proteins from ovarian follicles, testis and somatic tissues of rainbow trout, Oncorhynchus mykiss, were extracted by ultracentrifugation, separated on sodium dodecyl sulphate gels and isolated on polyvinyl difluoride membranes...
- Associations between patient report of symptoms and anatomic impairment visible on lumbar magnetic resonance imagingP F Beattie
University Sports Medicine, Department of Orthopaedics, College of Medicine and Dentistry, University of Rochester, Rochester, NY 14623, USA
Spine (Phila Pa 1976) 25:819-28. 2000..AND BACKGROUND DATA: Anatomic impairments of the intervertebral disc, radicular canal, and associated soft tissues are prevalent in people with and those without low back pain or lower extremity radiculopathy...
- Pharmacological characteristics of liriodenine, isolated from Fissistigma glaucescens, a novel muscarinic receptor antagonist in guinea-pigsC H Lin
Pharmacological Institute, College of Medicine, National Taiwan University, Taipei
Br J Pharmacol 113:275-81. 1994..of liriodenine, isolated from Fissistigma glaucescens, were determined in isolated trachea, ileum and cardiac tissues of guinea-pigs. 2...
- Hypertension and the coronary circulation. With special attention to endothelial regulationD G Harrison
Cardiology Division, Emory University School of Medicine, Atlanta, Georgia
Am J Hypertens 4:454S-459S. 1991Calcium channel antagonists are commonly used to treat chronic hypertension. Several studies of intact vascular tissues suggest that these agents may impair the production of the endothelium-derived relaxing factor and alter endothelium-..
- Vascular mode of action of kinin B1 receptors and development of a cellular model for the investigation of these receptorsL Levesque
, , Canada
Br J Pharmacol 109:1254-62. 1993..Krebs solution were slightly but not significantly attenuated in amplitude, as compared to paired control tissues bathed in Krebs solution, and sustained plateaus of contraction were observed in the absence of Ca2+...
- The influence of food additives and related materials on lower bowel structure and functionP M Newberne
Boston University School of Medicine, Massachusetts
Toxicol Pathol 16:184-97. 1988..tract under some defined conditions, resulting in morphological alterations in the mucosa and other tissues, deranged absorption and excretion of nutrients, and, in some cases, injury to other organs and tissues as a ..
- Reactivity of tissue-specific antigens in N-methyl-N'-nitro-N-nitrosoguanidine-induced neoplasms and normal tissues from medaka (Oryzias latipes)T E Bunton
Division of Comparative Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
Toxicol Pathol 24:331-8. 1996..filament proteins, and actin and S-100 proteins were labeled in MNNG-induced neoplasms and normal medaka tissues using specific monoclonal or polyclonal antibodies...
- Diet: the neglected variable in chemical safety evaluationsP M Newberne
Department of Pathology, Boston University School of Medicine, Massachusetts, USA
Toxicol Pathol 24:746-56. 1996..offer a brief introduction to a highly promising new digital specimen technology for evaluating histopathology of tissues from animals used in safety evaluations with the aid of computers...
- Alterations in membrane fatty acid unsaturation and chain length in hypertension as observed by 1H NMR spectroscopyY Chi
Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
Am J Hypertens 11:340-8. 1998..may account for altered membrane ion transport, elasticity, and contractility properties of hypertensive tissues. To investigate the abnormalities in membrane fatty acids in essential hypertension, the degree of fatty acid ..
- Pathology of ocular irritation with acetone, cyclohexanol, parafluoroaniline, and formaldehyde in the rabbit low-volume eye testJ K Maurer
The Procter and Gamble Co, Cincinnati, Ohio, USA
Toxicol Pathol 29:187-99. 2001..b>Tissues were obtained for light microscopic examination after 3 hours and on days 1, 3, and 35...
- [Effects of angiotensin II and pressure on cellular fibronectin in the vascular wall in organotypic culture]N Bardy
INSERM U141, , Paris
Arch Mal Coeur Vaiss 87:991-5. 1994Fibronectin is a dimeric glycoprotein found in the extracellular matrix of most tissues, which can influence processes, including cell growth, adhesion and migration...
- Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIPA Ben Jebria
Laboratoire de Physiologie, , , France
Br J Pharmacol 109:131-6. 1993..Passively sensitized human isolated bronchial rings were tissues incubated overnight in serum from asthmatic patients atopic to Dermatophagoides pteronyssinus and paired controls ..
- Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesisA Avignon
J A Haley Veterans Hospital, Tampa, Florida 33612, USA
Diabetes 45:1396-404. 1996....
- Clinical results of unconventional fractionation radiotherapy in central nervous system tumorsM Botturi
Radiotherapy Department, Ospedale Niguarda Ca' Granda, Milan, Italy
Tumori 84:176-87. 1998..irradiation exploits the differences in repair capacity between tumour and late responding normal tissues. It may allow for higher total dose and may result in increased tumor cell kill...
- Expression of fibroblast growth factor (FGF)-10 in human colorectal adenocarcinoma cellsA Matsuike
Department of Pathology, Nippon Medical School, Tokyo, Japan
J Nippon Med Sch 68:397-404. 2001..SW 480 and WiDr) and the localization of FGF-10 messenger RNA (mRNA) and its protein in human colorectal cancer tissues from 10 patients were determined. All five colorectal cancer cell lines expressed FGF-10 mRNA and its protein...
- Roles of protein kinase C on the mechanical activity of vascular smooth musclesT Itoh
Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Am J Hypertens 3:216S-219S. 1990..kinase C in the mechanical responses evoked by high K or by acetylcholine (ACh) in intact vascular smooth muscle tissues, and by Ca in skinned vascular smooth muscle tissues...
- Estrogen and progesterone receptor determinations in breast cancer. Technology, biology and clinical significanceS M Thorpe
Fibiger Institute, Laboratory of Tumor Endocrinology, Rigshospitalet, Copenhagen, Denmark
Acta Oncol 27:1-19. 1988..receptors (ER and PgR) has led to changes in treatment strategies: patients without receptors in their tumor tissues cannot be expected to respond to endocrine therapy...
- Pharmacological profile of GR117289 in vitro: a novel, potent and specific non-peptide angiotensin AT1 receptor antagonistM J Robertson
Department of Cardiovascular and Respiratory Pharmacology, Glaxo Group Research Ltd, Ware, Herts
Br J Pharmacol 107:1173-80. 1992..3, 1 or 3 nM) was not reversed by continuously washing the tissues for 3 h; in fact, the potency of GRI 17289 was slightly enhanced after this period.5...
- Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aortaA A Laniyonu
Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB Canada
Br J Pharmacol 114:1680-6. 1995..from animal weighing less than 180 g (< 6 weeks of age), but increased with animal size, plateauing in tissues derived from animals weighing between 320 and 420 g (about 9 to 14 weeks of age)...
- An anatomic study of neuropeptide immunoreactivities in the lumbar dura mater after lumbar sympathectomyY Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical College, Japan
Spine (Phila Pa 1976) 21:925-30. 1996..Many studies have indicated that the sinuvertebral nerve has an important role in innervating the tissues around the vertebrae...
- Effects of interleukin-1 alpha and cyclosporin A in vivo and in vitro on bone and lymphoid tissues in miceL K McCauley
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210
Toxicol Pathol 19:1-10. 1991..IL-1 alpha also had marked effects on spleen, thymus, and circulating blood cells; however, most parameters were not affected by the concurrent administration of cyclosporin A...
- On radiation damage to normal tissues and its treatment. II. Anti-inflammatory drugsA S Michalowski
MRC Cyclotron Unit, Hammersmith Hospital, London, UK
Acta Oncol 33:139-57. 1994..of observations are highly suggestive of a contribution of humoral factors to the adverse responses of normal tissues and organs to radiation...
- Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding geneK Nishida
Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA
Spine (Phila Pa 1976) 24:2419-25. 1999..Immunohistochemical staining for human transforming growth factor beta 1 was performed on the disc tissues of one rabbit from Group 1. Nucleus pulposus tissues from the remaining rabbits were cultured in serumless medium...
- The biphasic response of rat vesical smooth muscle to ATPC Bolego
Institute of Pharmacological Sciences, University of Milan, Italy
Br J Pharmacol 114:1557-62. 1995..by ATP and ATP analogues on rat bladder strips were characterized at resting tone and in carbachol-prestimulated tissues. 2...
- Autoimmune endocrine ophthalmopathy and retrobulbar antigensE Otto
Third Department of Medicine and Endocrinology, Johannes Gutenberg-University Hospital, Mainz, Germany
Horm Metab Res 27:533-8. 1995..Retrobulbar and abdominal tissue from 7 controls (4 fem., 48 - 74 y) was investigated, too. Tissues were homogenized and the proteins were separated by SDS-PAGE according to molecular weight...
- [Extracellular hydrolytic enzymes and their relevance during Candida albicans infections]F Stehr
Institut fur Allgemeine Botanik, AMP III,
Mycoses 43:17-21. 2000..albicans to survive on surfaces and the permit the fungus to invade tissues and organs in immunocompromised patients...
- Characterization of NK1 and NK2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systemsA Floch
Rhone Poulenc Rorer S A, Centre de Recherche de Vitry Alfortville, Vitry sur Seine, France
Br J Pharmacol 111:759-68. 1994..In contrast, in the guinea-pig, [3H]-SP bound with high affinity to these tissues (KD = 0.23 +/- 0.08 nM and 0.34 +/- 0.05 nM, for lungs and bronchi, respectively)...
- Demonstration of the suitability of CGP 12177 for in vivo studies of beta-adrenoceptorsM P Law
MRC Cyclotron Unit, Hammersmith Hospital, London
Br J Pharmacol 109:1101-9. 1993..Serial blood samples were taken from tail arteries to determine clearance from plasma. Rats were killed and tissues removed to determine tissue uptake. Radioactivity was assessed by liquid scintillation counting. 3...
- The human insulin-like growth factor-II promoter P1 is not restricted to liver: evidence for expression of P1 in other tissues and for a homologous promoter in baboon liverI H Jin
Medical Service, VA Medical Center, Palo Alto, California, USA
Horm Metab Res 27:447-9. 1995..Previously, promoter P1 had been found exclusively in human adult liver but not in other human tissues or in rat or mouse liver...
- Pathology of ocular irritation with bleaching agents in the rabbit low-volume eye testJ K Maurer
The Procter and Gamble Co, Cincinnati, Ohio, USA
Toxicol Pathol 29:308-19. 2001..Light microscopic examinations were conducted on tissues obtained at 3 hr and on 1, 3, and 35 days...
- Enzymes involved in purine metabolism--a review of histochemical localization and functional implicationsY Moriwaki
Third Department of Internal Medicine, Hyogo College of Medicine, Japan
Histol Histopathol 14:1321-40. 1999..However, from its wide range of localization in tissues it is also considered to be related to the membrane movement of cells in the transitional epithelium, cellular ..
- Regulation of vascular and gastric smooth muscle contractility by pervanadateA Laniyonu
Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB, Canada
Br J Pharmacol 113:403-10. 1994..kinase inhibitors (genistein, tyrphostin) and by Western blot analysis of phosphotyrosyl proteins in PV-treated tissues. The ability of PV to mimic the action of the tyrosine kinase receptor-associated agonist, epidermal growth ..
- [Nuclear factor-kappaB activity and its correlation with cell proliferation in non-small cell lung cancer tissues]Jian Zhang
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zhonghua Jie He He Hu Xi Za Zhi 30:771-5. 2007To investigate the nuclear factor (NF)-kappaB activity in human non-small cell lung cancer (NSCLC) tissues and to explore the correlation between NF-kappaB activity and cell proliferation, between NF-kappaB activity and cell spontaneous ..
- X-ray microanalysis of biological specimens by high voltage electron microscopyTetsuji Nagata
Department of Anatomy and Cell Biology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
Prog Histochem Cytochem 39:185-319. 2004For the purpose of analyzing and imaging chemical components of cells and tissues at the electron microscopic level, 3 fundamental methods are available, chemical, physical and biological...
- Effect of eye pigmentation on transscleral drug deliveryNarayan P S Cheruvu
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
Invest Ophthalmol Vis Sci 49:333-41. 2008..To determine the influence of eye pigmentation on transscleral retinal delivery of celecoxib...
- Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytomaJian Yu
Cancer Epigenetics and Gene Therapy, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200 25, Xie Tu Road, Shanghai 200032, China
BMC Cancer 4:65. 2004..Therefore, DNA methylation status as such may serve as an epigenetic biomarker for both diagnosis and prognosis of human tumors, including astrocytoma...
- Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinomaLi Ning Xu
Department of General Surgery of Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
World J Gastroenterol 11:3719-23. 2005..To study the role of Fas and Fas ligand (FasL) in biological behaviors of gallbladder carcinoma, and their correlated action and mechanism in tumor escape...
- Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem CellsLaura Gouder
Human Genetics and Cognitive Functions, Institut Pasteur CNRS URA 2182 Genes, Synapses and Cognition, Institut Pasteur Human Genetics and Cognitive Functions, Universit Paris Diderot, Sorbonne Paris Cit
J Vis Exp . 2015..pyramidal cells of the brain cortex, using both in vivo approaches and neuronal cultures obtained from rodent tissues. Neuropathological conditions can be associated to altered spine induction and maturation, as shown in rodent ..
- Effects of oral administration of berberine on distribution and metabolism of 2-aminofluorene in Sprague-Dawley ratsChin Chung Lin
Fong Yuan Hospital, Fong Yuan City 420, Taiwan
In Vivo 21:321-8. 2007..metabolism of 2-aminofluorene (2-AF) in bladder, blood, colon, kidney, liver, feces and urine samples and brain tissues (cerebrum, cerebellum and pineal gland) of male Sprague-Dawley rats were investigated...
- Distribution of keratin and associated proteins in the epidermis of monotreme, marsupial, and placental mammalsLorenzo Alibardi
Dipartimento di Biologia Evoluzionistica Sperimentale, University of Bologna, 40126, Bologna, Italy
J Morphol 258:49-66. 2003..1-3.0 microm) of keratohyalin granules (KHGs) associated with production of orthokeratotic corneous tissues. Those skin regions lacking hairs (platypus web), or showing reduced pelage density (wombat) have, respectively, ..
- Cytokine gene expression in peripheral blood mononuclear cells and tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis: evidence for an inherent proinflammatory gene expression patternPaul M Coussens
Department of Animal Science and Center for Animal Functional Genomics, Michigan State University, East Lansing Michigan 48824, USA
Infect Immun 72:1409-22. 2004..avium subsp. paratuberculosis. Cytokine gene expression in these cells and tissues was compared to expression in similar cells and tissues from control uninfected cattle...
- Distribution of trace elements in tissues of two shrimp species from the Persian Gulf and roles of metallothionein in their redistributionN Pourang
Department of Environment and Sustainable Agriculture, Ministry of Jahad e Agriculture, 7th Floor Tehran, Iran
Environ Int 31:325-41. 2005This study investigates the distribution of three trace elements (Cd, Cu and Zn) in tissues (exoskeleton, abdominal muscle and hepatopancreas) of two shrimp species (Penaeus merguiensis and Penaeus semisulcatus)...
- [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane]Martin Pierre Sauviat
Laboratoire d Optique et Biosciences, INSERM U 451 CNRS UMR 7645 X ENSTA, Ecole Polytechnique, 91128 Palaiseau, France
J Soc Biol 196:339-48. 2002..Absorbed through respiratory, digestive or transcutaneous pathways, lindane accumulates within lipid rich tissues. Lindane accumulation depends on the duration of the exposure and affects tissues in the following order: adipose ..
- Haloacetonitriles: metabolism and toxicityJohn C Lipscomb
Environmental Protection Agency, National Center for Environmental Assessment, Cincinnati, Ohio 45268, USA
Rev Environ Contam Toxicol 198:169-200. 2009..HANs are reactive and are toxic to gastrointestinal tissues following oral administration...
- Effects of luteolin on distribution and metabolism of 2-aminofluorene in male Sprague-Dawley ratsMei Due Yang
Department of Surgery, China Medical University Hospital, Taichung City, Taiwan
In Vivo 22:729-34. 2008..Major metabolites such as AAF, 1-OH-AAF, 3-OH-AAF, 8-OH-AAF and 9-OH-AAF were found in bladder tissues; AAF, 1-OH-AAF, 5-OH-AAF and 8-OH-AAF were found in blood samples; AAF, 1-OH-AAF, 3-OH-AAF, 5-OH-AAF, 8-OH-AAF ..
- Cathepsin D and carcino-embryonic antigen in serum, urine and tissues of colon adenocarcinoma patientsSlawomir Dariusz Szajda
Department of Pharmaceutical Biochemistry, Medical University of Białystok, Poland
Hepatogastroenterology 55:388-93. 2008..The objective of this study has been to evaluate CD activity in the blood serum, urine and tumor tissues as well as in the colon biopsies which were not changed macroscopically and CEA concentration in the serum of ..
- Effects of muscarinic M2 and M3 receptor stimulation and antagonism on responses to isoprenaline of guinea-pig trachea in vitroN Watson
Syntex Discovery Research, Institute of Pharmacology R2 101, Palo Alto, CA 94303
Br J Pharmacol 112:179-87. 19941. In guinea-pig and canine airway smooth muscle, there is reduced beta-adrenoceptor agonist sensitivity in tissues pre-contracted with muscarinic agonists when compared to tissues pre-contracted with other spasmogens, such as histamine ..
- Complement membrane attack complexes in pathologic disc tissuesMats Grönblad
Spine Research Unit Research Laboratory, Department of Orthopaedics and Traumatology, Institute of Surgery, University Central Hospital, University of Helsinki, Finland
Spine (Phila Pa 1976) 28:114-8. 2003Complement membrane attack complexes were located in lumbar spine disc tissues by immunohistochemistry...
- A comparative study of iron-related metabolic parameters in the eye of three animal speciesLUIS E VAZQUEZ-QUINONES
Department of Ophthalmologyy, School of Medicine, University of Puerto Rico, San Juan
P R Health Sci J 26:373-83. 2007..TI; Total Iron Binding Capacity, TIBC; Transferrin, Tf; and saturation of Tf) both in blood serum and in ocular tissues (lens, cornea, iris-ciliary body, retina) and fluids (vitreous body, aqueous humor) of several animal species (..
- [The influence of heat-induced epitope retrieval on endogenous avidin-binding activity (EABA) and blocking of EABA in immunohistochemistry]Xiaoge Zhou
Department of Pathology, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China
Zhonghua Bing Li Xue Za Zhi 31:491-6. 2002..To study the influence of heat-induced epitope retrieval (HIER) on endogenous avidin-binding activity (EABA) and to establish an effective way to block EABA in immunohistochemistry...
- NutritargetingHans Konrad Biesalski
Department of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany
Adv Food Nutr Res 54:179-217. 2008The term "nutritargeting" in analogy to the term "drug targeting" means targeting nutrients to specific "target" tissues. What is the rationale for this idea? Some tissues obviously are able to accumulate micronutrients selectively and ..
- Components of electroencephalographic responses to slaughter in halothane - anaesthetised calves : effects of cutting neck tissues compared with major blood vesselsT J Gibson
Animal Welfare Science and Bioethics Centre, Massey University, Palmerston North 4442, New Zealand
N Z Vet J 57:84-9. 2009To identify whether cutting neck tissues or cutting major blood vessels initiates the mechanisms responsible for electroencephalographic (EEG) responses to slaughter by ventral-neck incision without prior stunning in halothane-..
- The potential of amifostine: from cytoprotectant to therapeutic agentV Santini
Dept of Hematology, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
Haematologica 84:1035-42. 1999..It is a pro-drug of free thiol that may act as a scavenger of free radicals generated in tissues exposed to cytotoxic drugs, and binds to reactive metabolites of such drugs...
- Treatment of hemangioma by transfection of antisense VEGF geneShengguo Shan
Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China
J Huazhong Univ Sci Technolog Med Sci 29:335-9. 2009..Immunohistochemical method was used to detect the expression of PCNA in hemangioma tissues. According to the finding, 49 cases of hemangiomas fell into proliferating phase (27 cases) and involuting phase (..
- A novel fixative improves opportunities of nucleic acids and proteomic analysis in human archive's tissuesGiorgio Stanta
Department of Clinical, Morphological and Technological Sciences, University of Trieste, 34149 Trieste, Italy
Diagn Mol Pathol 15:115-23. 2006All tissues from biopsy or surgery origin are fixed and paraffin embedded as a routine procedure in the hospital departments of pathology...
- Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioningSøren Lykke Petersen
Lymphocyte Research Laboratory, Department of Hematology, Rigshospitalet, Copenhagen, Denmark
Dan Med Bull 54:112-39. 2007..rejection is an example of alloreactivity as alloreactivity denotes the immunologic reactions that occur when tissues are transplanted between two individuals within the same species...
- Proliferating cell nuclear antigen in hypertrophied spinal ligaments. Immunohistochemical localization of proliferating cell nuclear antigen in hypertrophied posterior longitudinal ligament of the cervical spineH Motegi
Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
Spine (Phila Pa 1976) 23:305-10. 1998..Surgically-extirpated specimens of posterior longitudinal ligament tissues from patients with hypertrophy of the posterior longitudinal ligament and other disorders of the cervical spine ..
- Comparison of concentrations of sulbactam-ampicillin administered by bolus injections or bolus plus continuous infusion in tissues of patients undergoing colorectal surgeryC Martin
Department of Anesthesia and Intensive Care, Nord Hospital, Marseilles University Hospital System and Marseilles Medical School, France
Antimicrob Agents Chemother 42:1093-7. 1998The concentrations of sulbactam and ampicillin were determined in sera and different abdominal tissues of 16 patients who underwent elective colorectal surgery. Patients were randomly allocated to two groups...
- Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesodermG Cossu
Istituto Pasteur Cenci Bolognetti, Universitá de Roma La Sapienza, Italy
Development 122:429-37. 1996..UPM) have been cultured either in isolation or with adjacent structures to investigate the influence of these tissues on myogenic differentiation in mammals...
- Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissuesYasuhiro Miki
Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
J Clin Endocrinol Metab 87:5760-8. 2002Estrogens play a key role in various target tissues. Enzymes involved in the biosynthesis and metabolism of these sex steroids also regulate estrogenic actions in these tissues...
- Is the Cry1Ab protein from Bacillus thuringiensis (Bt) taken up by plants from soils previously planted with Bt corn and by carrot from hydroponic culture?I Icoz
Laboratory of Microbial Ecology, Department of Biology, New York University, New York, NY 10003, USA
Bull Environ Contam Toxicol 83:48-58. 2009..In 2005, the Cry1Ab protein was detected by Western blot in tissues (leaves plus stems) of basil, carrot, kale, lettuce, okra, parsnip, radish, snap bean, and soybean but not in ..
- Differential expression of genes during aflatoxin B(1)-induced hepatocarcinogenesis in tree shrewsYuan Li
Department of Experimental Pathology, Guangxi Cancer Institute, Nanning 530021, Guangxi Zhuang Autonomous Region, China
World J Gastroenterol 10:497-504. 2004....
- Seasonal variations in bulk tissue, fatty acid and monosaccharide delta(13)C values of leaves from mesotrophic grassland plant communities under different grazing managementsJennifer A J Dungait
Organic Geochemistry Unit, Bristol Biogeochemistry Research Centre, University of Bristol, School of Chemistry, Cantocks Close, Bristol BS8 1TS, UK
Phytochemistry 71:415-28. 2010..on three sample dates (May, July and October) such that interspecific and spatiotemporal variations in whole leaf tissues and compound-specific delta(13)C values could be determined...
- Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tractLei Zeng
Clinical Research Institute, Sir Run Run Shaw Hospital, Zhejiang University, 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China
World J Gastroenterol 11:6202-7. 2005..and its inhibitor hepatocyte growth factor activator inhibitor type 1 (HAI-1) in normal and malignant tissues of gastrointestinal tract at mRNA level for further study on their correlations with tumor progression and ..
- Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assayJ D Wadsworth
MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
Lancet 358:171-80. 2001..forms of human prion disease: disease-related prion protein (PrP(Sc)) is readily detectable in lymphoreticular tissues. Quantitation of risk of secondary transmission, and targeting of risk reduction strategies, is limited by lack ..
- Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient miceAnne Ulrike Trendelenburg
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, D 79104 Freiburg i Br, Germany
Br J Pharmacol 138:1389-402. 2003..Release of (3)H-noradrenaline was elicited by electrical stimulation. 2. In tissues from wild-type (WT) mice, angiotensin II and bradykinin increased the overflow of tritium evoked by 120 pulses at ..
- [Variabilities of the impacts of cold pathogen and cold-dampness pathogen on fractalkine mRNA expression in lung tissues of rats]Wei Zhang
Department of Respiratory Medicine, Affiliated Hospital, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
Zhong Xi Yi Jie He Xue Bao 6:171-5. 2008To study the variabilities of the effects of cold pathogen and cold-dampness pathogen on the fractalkine (FKN) mRNA expression in lung tissues of rats.
- Does variability in carotenoid composition and concentration in tissues of the breast and reproductive tract in women depend on type of lesion?E Czeczuga-Semeniuk
Department of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, Poland
Adv Med Sci 53:270-7. 2008..The study objective was to compare the carotenoid content in benign and malignant lesions of the breast, ovary and uterus, and to demonstrate quantitative and qualitative similarities or differences between the study groups...
- LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lungKuniaki Nakanishi
Department of Pathology, National Defense Medical College, Tokorozawa 359 8513, Japan
Virchows Arch 448:142-50. 2006..examined: (1) the levels of LAT1 mRNA/glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA in 41 normal lung tissues and 34 NMBAC using semiquantitative reverse transcription-polymerase chain reaction; (2) LAT1 mRNA and protein ..
- New tetrachromic VOF stain (Type III-G.S) for normal and pathological fish tissuesC Sarasquete
Instituto de Ciencias Marinas de Andalucia, CSIC, Poligono Rio San Pedro, Apdo Oficial, Puerto Real, Cadiz, Spain
Eur J Histochem 49:211-27. 2005A new VOF Type III-G.S stain was applied to histological sections of different organs and tissues of healthy and pathological larvae, juvenile and adult fish species (Solea senegalensis; Sparus aurata; Diplodus sargo; Pagrus auriga; ..
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..Researchers want to study these people and follow them over time. They also want to study body tissues and blood to understand the nature of eye disease...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..Researchers want to study these people and follow them over time. They also want to study body tissues and blood to understand the nature of eye disease...
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Chymase-Mediated MMP Activation in Ishemia Reperfusion InjuryLOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013..The damage that occurs after the restoration of the blood flow to ischemic tissues or organs has deleterious consequences in various clinical settings such as thrombolytic therapy, cardiopulmonary ..
- Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: PreclinicYasmin Wadia; Fiscal Year: 2013..Laser Tissue Welding, Inc. (LTW) uses a non-compressive, non-ablative technology to join and seal tissues for controlling the leakage of blood, gastrointestinal fluids, urine, bile, lymph, and cerebrospinal fluid...
- Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic DiseasStephen C Strom; Fiscal Year: 2010..humanized mouse" Somatic cells such as fibroblasts from patients with diseases can be used to create cell lines, tissues, and perhaps, organ systems, through induced pluripotent stem cell (iPSC) technology...
- Optimization of DNA Repair by Abh8Lauren Endres; Fiscal Year: 2013..will use whole body radiation to initiate tumor development and investigate DNA repair capacity in radiosensitive tissues (i.e., thymic B-cells and intestinal crypt cells) by H2AX staining and using the COMET assay...
- Xenoestrogen regulation of Leydig cellsBENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010DESCRIPTION (provided by applicant): Soy isoflavones possess estrogenic properties, and reproductive tract tissues (including Leydig cells) express estrogen receptors (ER1 and ER2)...
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..how to prevent NAFLD and its progression to NASH depends upon a better understanding of why fat accumulates in tissues and why the amount of fat that accumulates usually correlates with the degree of insulin resistance...
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2011..Periodontitis is initiated by bacterial infection of the gingival tissues through a subgingival microbial biofilm on the tooth surface that releases bacterial lipopolysaccharide (LPS) and ..
- Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS FactorVirginia J Savin; Fiscal Year: 2010..CLC-1 is a cytokine of the IL-6 family that is synthesized by cells in many tissues. CLC-1 rapidly increases Palb in a concentration-dependent fashion...
- Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)James D Bryers; Fiscal Year: 2012..Chronic periodontitis is an inflammatory disease of the supporting tissues of the teeth leading to resorption of alveolar bone and eventual tooth loss...
- Identification of Genetic and Epigenetic Alterations in SpondyloarthritisTibor T Glant; Fiscal Year: 2013..Moreover, St6galnac6 was highly expressed in inflamed soft tissues of the spine (in areas of peridiscitis and enthesitis) in BALB/c mice, and the St6galnac6 promoter was heavily ..
- MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSIONCarole R Mendelson; Fiscal Year: 2013..In the proposed research, we will utilize fetal lung tissues from humans and mice to further define the underlying biochemical and molecular mechanisms for epigenetic and ..
- Iron-mediated vascular disease in sickle cell disease.John C Wood; Fiscal Year: 2010..Prolonged exposure to iron of the heart, liver, endocrine glands and other tissues results in severe oxidant damage, organ failure, malignant transformation and death, if unrecognized and ..
- Role of NGF in inflammatory and proliferative cascades of psoriatic diseaseSiba P Raychaudhuri; Fiscal Year: 2012..Blood, synovial fluid (SF) and synovial tissues of PsA (n=25) and controls [OA (n=20) and RA (n=10)] will also be examined to identify an immunoregulatory role ..
- Role of Chromogranin A in Metabolic SyndromeSushil K Mahata; Fiscal Year: 2013..the chromogranin/secretogranin protein family, is a pro-protein that is ubiquitously expressed in neuroendocrine tissues. Proteolytic processing of Chga gives rise to biologically active peptides such as the dysglycemic hormone ..
- Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV iBapi Pahar; Fiscal Year: 2010..hypothesize that the level of antigen-antibody binding properties and antigen-specific effector memory B cells in tissues or secretory Ig will correlate with the reduction of viral load or disease progression in SIV infected macaques...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2013..To investigate if air pollution exposure contributes to adiposity and inflammation in adipose tissues that induces insulin resistance and vascular dysfunction, we hypothesize that exposure to fine particulate matter ..
- Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular TissueJAMES RUSSELL SOWERS; Fiscal Year: 2013..insulin resistance will be investigated in primary cultured cells and in vivo/ex vivo studies in cardiovascular tissues of rodents with excess long-term exposure to Ang II and/or aldosterone, with and without Ang II and ..
- Targeting Galectin-3 with novel drugs for treatment of eczemaFu Tong Liu; Fiscal Year: 2010..Through extensive studies of transgenic mice and human tissues, we have identified galectin-3 as a key molecule involved in skin inflammation...
- Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate CancerBandana Chatterjee; Fiscal Year: 2013..high levels of this protein promote excessive and uncontrolled multiplication of cells in the prostate and other tissues, causing cancer...
- Structure and function of urea transportersMing Zhou; Fiscal Year: 2013..UTs are highly expressed in many mammalian tissues, including kidney, liver, and brain...
- Roles of Nitric Oxide and Superoxide in CystitisANTHONY JOHN KANAI; Fiscal Year: 2013..Cells and tissues will be stained with voltage- or Ca2+-sensitive dyes and/or afferent nerves labeled using pseudorabies virus (..
- Non-viral Genetic Modification of Antigen-presenting Cells in AllograftsWilson S Meng; Fiscal Year: 2011..to develop methods to introduce the IL-10 gene ex vivo into donor dendritic cells (DCs) reside within transplant tissues. The phenotype of donor DCs dictates the fate of transplants in recipients...
- Role of SCD1 and Dietary Methionine Restriction on Energy HomeostasisERIC PAUL PLAISANCE; Fiscal Year: 2011..abundance which increases food intake and results in a series of unresolved signaling events in peripheral tissues that lead to increased energy expenditure and decreased body-fat...
- Regulation of B Cell Function by Membrane-Cytoskeletal RemodelingNeetu Gupta; Fiscal Year: 2012..To function effectively, B cells need to migrate in the lymphoid tissues for surveillance, and upon binding pathogenic proteins they need to reorganize their surface components for ..
- DNA Damage and Response in the Bladder Microenvironment.Bradley P Dixon; Fiscal Year: 2013..The gastrointestinal tissues in an augmented bladder are significantly more likely to develop cancer than the native bladder tissue, although ..
- N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus InfectiAquilur Rahman; Fiscal Year: 2010..N- MCT has no apparent cytotoxicity in uninfected tissues, in contrast to cidofovir, which requires hospitalization to treat its associated renal toxicity...
- THE ROLE OF ACETYLATION IN MITOCHONDRIAL FUNCTIONGary Cecchini; Fiscal Year: 2013..Therefore, tissues from control and SIRT3-/- KO mouse models will be isolated and intact mitochondria, alamethicin permeabilized ..
- Immunomodulatory and regenerative effects of mesenchymal stem cells on allograftsNorma S Kenyon; Fiscal Year: 2013..Aim 3. Analyze the proteomic, genomic and phenotypic changes that occur in the peripheral blood and tissues of monkey recipients of islet or renal/MSC co-transplants to define biomarkers common to MSC efficacy/non-..
- Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and AnimalMarcelo B Sztein; Fiscal Year: 2013..dysenteriae 1 correlate with protection and are representative of those present at effector sites (i.e., mucosal tissues) and secondary lymphoid organs...
- A Soft Topical Antiandrogenic DrugWei Chu Xu; Fiscal Year: 2013..S)-HYG-440 was designed to avoid systemic activity by taking advantage of esterases and hydrolases found in most tissues in the body for metabolic deactivation, i.e. as a metabolically "soft" drug...
- MOLECULAR BASIS OF REOVIRUS PATHOGENESISTerence S Dermody; Fiscal Year: 2013..Reovirus attachment protein a^ Influences the pathway of viral spread in the host and tropism for target tissues. The al protein is a filamentous trimer that binds to junctional adhesion molecule-A (JAM-A) and cell-surface ..
- Iron, Metabolic Regulation and Type 2 Diabetes RiskDonald A McClain; Fiscal Year: 2013DESCRIPTION (provided by applicant): High iron levels in blood and tissues are a risk factor for diabetes mellitus...
- Induction and maintenance of regulatory T cellsMitchell Kronenberg; Fiscal Year: 2013..system has evolved to mount robust responses against invading pathogens, but at the same time is tolerant to self-tissues or self-antigens. The mechanisms governing immune tolerance are not clear...
- Retinoid Metabolism and Alcohol Induced DiseaseWilliam S Blaner; Fiscal Year: 2010..retinoid metabolism and actions in liver (where 70% of the body's retinoid is stored) and in peripheral tissues. Alcoholics generally have very reduced hepatic and tissue retinoid levels...
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010..hyperplasia of the lymph glands, over-proliferation of immature blood cells, and severe growth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
- Trichothecene Toxicity and the Ribotoxic Stress ResponseJames J Pestka; Fiscal Year: 2012..ricin, Shiga toxin, anisomycin) induce proinflammatory gene expression and apoptosis in lymphoid tissues. Because of their potential for use in chemical terrorism, trichothecenes and other ribotoxins are now included ..
- Role of IKK in NSCLC: Modulation of SMRT and NF-kappaBMarty W Mayo; Fiscal Year: 2012..Aim 3 will examine the role of NF-?B in epigenetic reprogramming using human tumor tissues and lung metastasis models...
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2009..referred to as biologics) include vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, monoclonal antibodies, and recombinant therapeutic proteins that are used to treat or protect humans or animals...
- Rac GTPase signaling during embryonic salivary gland branching morphogenesisSharon Sequeira; Fiscal Year: 2012..challenge of stimulating and/or maintaining salivary epithelial cell differentiation in artificially engineered tissues has been hindered by the lack of knowledge of precise molecular signaling mechanisms that control glandular ..
- Prostate cancer chemoprevention by penta-galloyl-glucoseJunxuan Lu; Fiscal Year: 2013..g., cyclin D1, p-Stat3, Bcl-2 family, VEGF) using suitable tissues from Aim 4...
- Controlling Radiation Injury by TLR5 AgonistsAndrei V Gudkov; Fiscal Year: 2012..The toxicity of ionizing radiation (IR) in mammals is largely due to damage to the most radiosensitive tissues, the gastrointestinal (GI) tract and the hematopoietic (HP) system...
- Cellular &Molecular Defects in Human B Cell DevelopmentCharlotte Cunningham-Rundles; Fiscal Year: 2013..These new discoveries made using human tissues clearly promise further advances in understanding human B cell biology...
- Transgenesis and XenotransplantationJorge A Piedrahita; Fiscal Year: 2013..the swine genome to generate genetically modified animals has the potential to provide a novel source of cells/tissues for clinical applications...
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJERROLD MICHAEL OLEFSKY; Fiscal Year: 2013..Finally, CD11c+ macrophage represents the majority of the macrophages recruited into obese adipose tissues. These cells are highly proinflammatory releasing large amounts of tissue cytokines which can cause insulin ..
- Vascular dysfunction and oxidative stress in primary amyloidosisRAYMOND QUEZON MIGRINO; Fiscal Year: 2010..that amyloid light chains cause oxidative stress leading to tissue damage or dysfunction in colon and cardiac tissues. There is evidence that early endothelial dysfunction precedes onset of amyloid deposition and that amyloid light ..
- Role of Diabetes in Development of Renal Cell CarcinomaSAMY LEWIZ HABIB; Fiscal Year: 2013..function and mutations of OGG1 gene and accumulation of significant amounts of 8-oxodG in animal and human kidney tissues. Certain agonists activate PI-3 kinase and Akt, which stimulate tuberin phosphorylation resulting in its ..
- Monitoring cellular redox signaling and oxidant stress in vivoPaul T Schumacker; Fiscal Year: 2010..New methods to monitor intracellular oxidant stress in intact tissues could enhance our understanding of how cell-cell interactions and tissue microenvironments influence the ..
- TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion InjuryLORI ANN HOLLE; Fiscal Year: 2011DESCRIPTION (provided by applicant): ABSTRACT Interruption and subsequent restoration of circulation in tissues causes varying amounts of ischemia- reperfusion injury (IRI)...
- The role of IKK beta in cardiomyocytes at baseline and following stressMATTHEW PETER COGGINS; Fiscal Year: 2013..kappa B cells (NF-kB) family of transcription factors regulates a wide range of essential processes in multiple tissues, from inflammation to cell survival...
- A unique approach to identify markers for congenital syphilis and neurosyphilisNikhat Parveen; Fiscal Year: 2010..with a few potential surface proteins that can determine the spirochete's ability to colonize various tissues during infection...
- Protein Nitration in the PlacentaLeslie Myatt; Fiscal Year: 2012..in isolated heavy (syncytiotrophoblast) and light (cytotrophoblast) mitochondrial fractions, comparing tissues from normal pregnancies with mild late onset or severe early onset preeclampsia...
- Clinical , Mechanical and Chemical Evaluation of Amalgam and ART RestorationsLilliam Marie Pinzon; Fiscal Year: 2013..of the restoration/tooth interfaces (Nanoindentation, and SEM-EDS) to identify changes induced in the tissues by the restorative materials and to provide insight to the mechanisms that could induce such changes...
- Regulation of Cell Signaling by Human Biliverdin ReductaseMahin D Maines; Fiscal Year: 2013..BVR is expressed to a varying degree in all tissues, the liver parenchyma cells are the primary site of its activity...
- Tissue-specific delivery of probes by control of membrane trafficking of endoprotBlake Peterson; Fiscal Year: 2010..is how to transport poorly permeable molecules across membrane barriers and release them in specific cells or tissues. The way that Nature solves this problem is through membrane trafficking;cell impermeable ligands such as the ..
- New insights in mechanisms of renal injuryBalakuntalam S Kasinath; Fiscal Year: 2013..Upstream regulators and downstream effectors of GSK 3beta in transcription and translation pathways involved in matrix protein synthesis will be explored in renal tissues as stated in Aim 1.
- Iron in the pathogenesis of Friedreich's ataxiaARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013..It is also unlikely that human autopsy tissues are suitable for the direct determination of this small pool of highly reactive iron...
- Recombinant Attenuated Salmonella Vaccines for HumansRoy Curtiss; Fiscal Year: 2012..Paratyphi A vaccine exhibiting regulated delayed lysis within effector lymphoid tissues in the immunized individual to deliver hepatitis B virus (HBV) core particles with fused preS1, preS2 and T-cell ..
- Intracellular Phase Diagram Creation Using a Micro-Differential Scanning CalorimeGARY L SOLBREKKEN; Fiscal Year: 2010DESCRIPTION (provided by applicant): The advent of artificial tissues, cord blood therapies, cell transplantation procedures, and the desire to bank germ cells have driven the need to establish a means to reliably store biological ..
- The Neuroimmunology of Viral InfectionDANIEL J CARR; Fiscal Year: 2013..this project will identify key central components of innate and adaptive immunity within the CNS and peripheral tissues (including sensory ganglia and cornea) that are critical for viral surveillance unique to each tissue...
- ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAEANTHONY JUSTIN MUSLIN; Fiscal Year: 2010..are regulated by the action of the hormone insulin that is released from the pancreas and that acts in many tissues throughout the body, causing glucose to go into cells and out of the bloodstream...
- Molecular mechanisms of lung disease in ataxia telangiectasiaJoAnn M Sekiguchi; Fiscal Year: 2013..We have generated a conditionally inactivatable allele of ATM that can be deleted in specific tissues. Using this unique model system, we can examine the involvement of particular tissues and cell types in the ..
- Polarization and directed cell movements in engineered cellular environmentsDeborah E Leckband; Fiscal Year: 2010..signals by disrupting intercellular contacts in ways that fundamentally impact the organization and integrity of tissues. This research exploits the enabling tools of soft lithography and live cell imaging to define quantitative ..
- Novel Use of Confocal Microscopy on Cultured Porcine Corneas for Pre-Clinical TesMichelle Piehl; Fiscal Year: 2011..EpiOcular " tissues are exposed to test substances and then tissue viability is measured by reduction of a metabolic indicator...
- Pathogenesis of Lyme Borreliosis in the Rhesus MonkeyMARIO PHILIPP; Fiscal Year: 2007..burgdorferi spirochetes can cause inflammatory responses in CNS cells and tissues, and 2) these inflammatory responses may lead to neural injury, and ultimately to loss of glial and neuronal ..
- Mucosal Memory T Cells at the Vanguard of Human Host DefenseDonna L Farber; Fiscal Year: 2010..While both of these organs harbor resident immune cells for providing host defense in these tissues, this indigenous immunity is not sufficient to protect against succumbing to illness and even mortality from ..
- Phospholipid Nanocarriers Improve Chemotherapy by Targeted Drug DeliveryHayat Onyuksel; Fiscal Year: 2010..conventional approaches is undesirable drug side effects due to nonspecific drug exposure to healthy cells and tissues resulting in limited dosing schedule and therapeutic effects of drug...
- Validation and Quantification of FFPE Antigen Retrieval by Proteome AnalysisXUPEING FANG; Fiscal Year: 2010..liquid chromatography system, the lack of optimized methodologies for retrieving proteins from FFPE tissues further restricts the ability to perform the molecular analysis of archival tissues. By collaborating with Drs...
- Phase-contrast enhanced X-ray imaging system for small joints of handThomas J Beck; Fiscal Year: 2010..While having good contrast for joint soft tissues, these methods lack enough spatial resolution for small joints such as those of the hand...
- Regulation of neurotrophin expression in the peripheryLORI ISAACSON; Fiscal Year: 2009..factor (NGF) and that high molecular weight (MW) NGF species are predominant in peripheral neurons and target tissues. In contrast, we observed that mature neurotrophin-3 (NT-3), along with a high MW precursor, are prevalent in ..
- Enabling Strategies for Growing Collagenous TissuesLAURA E contact NIKLASON; Fiscal Year: 2010Connective soft tissues, which include skin, fascia, ligament, tendon, blood vessel, etc, rely upon extracellular matrix to provide the bulk of their mechanical properties...
- Directed Self Assembly of Complex Branching Micro-TissuesJEFFREY R contact MORGAN; Fiscal Year: 2010..developed a new technology based on micro-molded nonadhesive agarose to guide the self assembly of 3D micro-tissues. Mono-disperse cells are pipetted into the micro-mold, they settle into the molded features, are unable to bind ..
- Adenovirus Persistence in Human Lymphoid TissuesLinda Gooding; Fiscal Year: 2007..Early investigators found adenoviral DNA in lymphoid tissues in the absence of infectious virus, suggesting a stage of virus infection in which the virus is dormant in some ..
- Ninth International Conference on the Chemistry and Biology of Mineralized TissuePaul Krebsbach; Fiscal Year: 2007..provided by applicant): The Ninth International Conference on the Chemistry and Biology of Mineralized Tissues is planned for November 4-7, 2007, at the Lakeway Inn Conference Resort in Austin, Texas...
- 8th Conference - Chemistry & Biology Mineralized TissueWILLIAM LANDIS; Fiscal Year: 2004The Eighth International Conference on the Chemistry and Biology of Mineralized Tissues is planned for October 17-22, 2004, to take place at the Banff Centre, Alberta, Canada...
- Effect of Crohn's Disease Risk Alleles on Enteric MicrobiotaEllen Li; Fiscal Year: 2010..Analyze the effect of CD-risk alleles on mucosal associated microbiota in GI tissues collected from ileal CD, non-ileal IBD and non-IBD patients;2...