salivary glands

Summary

Summary: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).

Top Publications

  1. pmc Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation
    Yoshinori Sumita
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Int J Biochem Cell Biol 43:80-7. 2011
  2. ncbi Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation
    Jielin Feng
    Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Radiother Oncol 92:466-71. 2009
  3. ncbi The Lyme disease agent exploits a tick protein to infect the mammalian host
    Nandhini Ramamoorthi
    Sections of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 436:573-7. 2005
  4. ncbi Oral sequelae of head and neck radiotherapy
    A Vissink
    Department of Oral and Maxillofacial Surgery, University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Crit Rev Oral Biol Med 14:199-212. 2003
  5. pmc Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes
    Ma Isabel Salazar
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
    BMC Microbiol 7:9. 2007
  6. pmc Efficiency of salivary gland invasion by malaria sporozoites is controlled by rapid sporozoite destruction in the mosquito haemocoel
    JULIAN F HILLYER
    Center for Microbial and Plant Genomics and Department of Microbiology, University of Minnesota, 1500 Gortner Ave, Saint Paul, MN 55108, USA
    Int J Parasitol 37:673-81. 2007
  7. pmc Rescue of salivary gland function after stem cell transplantation in irradiated glands
    Isabelle M A Lombaert
    Section Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 3:e2063. 2008
  8. ncbi Bone marrow-derived cells: A potential approach for the treatment of xerostomia
    Simon D Tran
    McGill University, Faculty of Dentistry, Montreal, Canada
    Int J Biochem Cell Biol 43:5-9. 2011
  9. ncbi Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 92:118-25. 2012
  10. pmc Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infection
    Mathieu Dubrulle
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
    PLoS ONE 4:e5895. 2009

Detail Information

Publications398 found, 100 shown here

  1. pmc Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation
    Yoshinori Sumita
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Int J Biochem Cell Biol 43:80-7. 2011
    ..A consequence of this treatment is irreversible damage to salivary glands (SGs), which is accompanied by a loss of fluid-secreting acinar-cells and a considerable decrease of saliva ..
  2. ncbi Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation
    Jielin Feng
    Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Radiother Oncol 92:466-71. 2009
    ..we showed that transplantation of 100-300 c-Kit(+) stem cells isolated from cultured salispheres ameliorates radiation-damage in murine salivary glands. The aim of this study is to optimize and translate these findings from mice to man.
  3. ncbi The Lyme disease agent exploits a tick protein to infect the mammalian host
    Nandhini Ramamoorthi
    Sections of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 436:573-7. 2005
    ..scapularis drastically reduced the capacity of tick-borne spirochaetes to infect mice. These results show the capacity of a pathogen to use a secreted arthropod protein to help it colonize the mammalian host...
  4. ncbi Oral sequelae of head and neck radiotherapy
    A Vissink
    Department of Oral and Maxillofacial Surgery, University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Crit Rev Oral Biol Med 14:199-212. 2003
    ..g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints...
  5. pmc Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes
    Ma Isabel Salazar
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
    BMC Microbiol 7:9. 2007
    ..must infect midgut epithelial cells, replicate and disseminate into the hemocoel, and finally infect the salivary glands, which is essential for transmission...
  6. pmc Efficiency of salivary gland invasion by malaria sporozoites is controlled by rapid sporozoite destruction in the mosquito haemocoel
    JULIAN F HILLYER
    Center for Microbial and Plant Genomics and Department of Microbiology, University of Minnesota, 1500 Gortner Ave, Saint Paul, MN 55108, USA
    Int J Parasitol 37:673-81. 2007
    ..transmission to the vertebrate host, malaria sporozoites must migrate from the mosquito midgut to the salivary glands. Here, using purified sporozoites inoculated into the mosquito haemocoel, we show that salivary gland ..
  7. pmc Rescue of salivary gland function after stem cell transplantation in irradiated glands
    Isabelle M A Lombaert
    Section Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 3:e2063. 2008
    ..Our approach is the first proof for the potential use of stem cell transplantation to functionally rescue salivary gland deficiency...
  8. ncbi Bone marrow-derived cells: A potential approach for the treatment of xerostomia
    Simon D Tran
    McGill University, Faculty of Dentistry, Montreal, Canada
    Int J Biochem Cell Biol 43:5-9. 2011
    ..BMDCs positively affect blood vessels stability and regeneration in irradiated salivary glands. Also, BMDCs provide an immunomodulatory activity in mice with Sjögren's-like disease...
  9. ncbi Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 92:118-25. 2012
    ..In the absence of any contrary evidence, hCMV can reasonably be designated an "oncovirus."..
  10. pmc Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infection
    Mathieu Dubrulle
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
    PLoS ONE 4:e5895. 2009
    ..albopictus. As Ae. albopictus tends to replace Ae. aegypti in many regions, one question remained: is Ae. albopictus as efficient as Ae. aegypti to transmit the variant E1-226V of CHIKV?..
  11. pmc Glycoinositolphospholipids from Trypanosomatids subvert nitric oxide production in Rhodnius prolixus salivary glands
    Felipe Gazos-Lopes
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 7:e47285. 2012
    ..rangeli invades salivary glands and is inoculated into the host skin...
  12. ncbi Blood-feeding and immunogenic Aedes aegypti saliva proteins
    Ladawan Wasinpiyamongkol
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Proteomics 10:1906-16. 2010
    ..We have generated for the first time the 2-DE profiles of immunogenic Ae. aegypti SG BF-related proteins. These new data could contribute to the understanding of the physiological processes that appear during the blood meal...
  13. pmc Spatial mapping of gene expression in the salivary glands of the dengue vector mosquito, Aedes aegypti
    Jennifer Juhn
    Department of Molecular Biology and Biochemistry, University of California, Irvine, USA
    Parasit Vectors 4:1. 2011
    ..Mosquito salivary glands are organs involved directly in pathogen transmission to vertebrate hosts...
  14. ncbi The Plasmodium sporozoite journey: a rite of passage
    Stefan H I Kappe
    Michael Heidelberger Division, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Trends Parasitol 19:135-43. 2003
    ..This article discusses recent work, mostly done with rodent malaria parasites, that has contributed to a better understanding of the sporozoites' complex biology and which has opened up new avenues for future sporozoite research...
  15. ncbi Cell therapy for salivary gland regeneration
    C Y Lin
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University
    J Dent Res 90:341-6. 2011
    ..that transplantation with bone marrow stem cells or acinar-like cells may help functional regeneration of salivary glands. Bone marrow stem cells were labeled with nanoparticles and directly co-cultured with acinar cells to obtain ..
  16. ncbi Salivary gland branching morphogenesis
    Vaishali N Patel
    Matrix and Morphogenesis Unit, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Dr Bethesda, MD 20892, USA
    Differentiation 74:349-64. 2006
    ..A broader section mentions other molecules implicated from analysis of the phenotypes of genetically modified mice or organ culture experiments. The review concludes with speculation on some future areas of research...
  17. ncbi Transcription factor AP2-Sp and its target genes in malarial sporozoites
    Masao Yuda
    Department of Medical Zoology, Mie University School of Medicine, Mie, Tsu, 514 0001, Japan
    Mol Microbiol 75:854-63. 2010
    ..These results indicate that AP2-Sp is a major transcription factor that regulates gene expression in the sporozoite stage...
  18. ncbi Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand
    Amornrat Waitayakul
    Department of Parasitology, Faculty of Medical Technology, Mahidol University, Salaya, Nakhonpathom, Thailand
    Acta Trop 98:66-73. 2006
    ..Immunohistochemical staining of Anopheles salivary glands with human sera showed that the salivary gland-specific IgGs reacted strongly with the median lobe...
  19. pmc The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands
    Min Zhang
    Michael Heidelberger Division, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 207:1465-74. 2010
    ..the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host...
  20. ncbi Salivary gland protein repertoire from Aedes aegypti mosquitoes
    Lionel Almeras
    Unité de Recherche en Biologie et Epidémiologie Parasitaires UMR6236 IFR48, Institut de Médecine Tropicale du Service de Santé des Armées IMTSSA, Marseille, France
    Vector Borne Zoonotic Dis 10:391-402. 2010
    ..One hundred and twenty proteins were identified in these salivary glands representing the largest description of the Ae. aegypti salivary gland protein catalog...
  21. ncbi Regeneration of irradiated salivary glands with stem cell marker expressing cells
    Lalitha S Y Nanduri
    Department of Cell Biology, Section Radiation and Stress Cell Biology, University of Groningen, The Netherlands
    Radiother Oncol 99:367-72. 2011
    ..This study aims to better characterize the stem/progenitor cell population with regenerative potential residing in the mouse salivary gland...
  22. ncbi Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands
    S Das
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA
    J Infect Dis 184:1056-64. 2001
    ..Expression of these 14 genes in engorged tick salivary glands was confirmed by reverse-transcription polymerase chain reaction. The I...
  23. ncbi Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation
    C M Krane
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 276:23413-20. 2001
    ..These data show that AQP5 is the major pathway for regulating the water permeability in acinar cells, a critical property of the plasma membrane which determines the flow rate and ionic composition of secreted saliva...
  24. pmc Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis
    Jennifer M Anderson
    Laboratory of Malaria and Vector Research, NIAID, NIH, USA
    BMC Genomics 7:52. 2006
    ..Further knowledge of the repertoire of these salivary proteins will give us insights into the molecular evolution of these proteins and will help us select relevant antigens for the development of a vector based anti-Leishmania vaccine...
  25. pmc Progression of Plasmodium berghei through Anopheles stephensi is density-dependent
    Robert E Sinden
    Division of Cell and Molecular Biology, Faculty of Life Sciences, Imperial College London, London, United Kingdom
    PLoS Pathog 3:e195. 2007
    ....
  26. ncbi Discovery of gene function by expression profiling of the malaria parasite life cycle
    Karine G Le Roch
    Department of Cell Biology ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 301:1503-8. 2003
    ..Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes...
  27. pmc Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following Infection with Dengue Virus
    Natthanej Luplertlop
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Pathog 7:e1001252. 2011
    ..aegypti). Infection of the mosquito's salivary glands by DENV is the final step prior to viral transmission...
  28. ncbi Toward a description of the sialome of the adult female mosquito Aedes aegypti
    J G Valenzuela
    Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, MD 20892 0425, USA
    Insect Biochem Mol Biol 32:1101-22. 2002
    To describe the set of mRNA and protein expressed in the salivary glands (sialome) of Aedes aegypti mosquitoes, we randomly sequenced a full-length cDNA library of this insect and performed Edman degradation of PVDF-transferred protein ..
  29. ncbi Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi
    Jesus G Valenzuela
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, 12735 Twinbrook Parkway, Room 2E 22C, Rockville, MD 20852, USA
    J Exp Biol 207:3717-29. 2004
    ..biology approaches, we have isolated and identified the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis...
  30. pmc An insight into the sialome of the soft tick, Ornithodorus parkeri
    Ivo M B Francischetti
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Insect Biochem Mol Biol 38:1-21. 2008
    ..As happens to all genera of blood-sucking arthropods, several new proteins were also found, indicating the process of adaptation to blood feeding still continues to recent times...
  31. pmc The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response
    Bradley S Schneider
    Institut Pasteur, Departement de Parasitologie, Unités de Réponses Précoces aux Parasites et Immunopathologie, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Trans R Soc Trop Med Hyg 102:400-8. 2008
    ..Compared with arbovirus infection initiated in the absence of the mosquito or its saliva, infection via mosquito saliva leads to an increase in virus transmission, host susceptibility, viraemia, disease progression and mortality...
  32. ncbi Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation
    Isabelle M A Lombaert
    Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 14:7741-50. 2008
    During radiotherapy for head and neck cancer, co-irradiation (IR) of salivary glands results in acute and often lifelong hyposalivation...
  33. pmc Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands
    Tara Bullard
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Biol 320:72-8. 2008
    ..tracing shows that these cells are progenitors of both acinar and ductal cell types in all three major salivary glands. In the differentiated progeny, expression of Ascl3 is down-regulated...
  34. ncbi Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome
    Michael Voulgarelis
    Department of Pathophysiology, Medical School, National University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece
    Nat Rev Rheumatol 6:529-37. 2010
    ....
  35. ncbi Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity
    Alena Skalova
    Department of Pathology, Charles University, Pilsen, Czech Republic
    Am J Surg Pathol 34:599-608. 2010
    ..For this tumor, we propose a designation mammary analogue secretory carcinoma of salivary glands (MASC). The 16 patients comprised 9 men and 7 women, with a mean age of 46 years (range 21 to 75)...
  36. ncbi Transplantation of cultured salivary gland cells into an atrophic salivary gland
    T Sugito
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8440, Japan
    Cell Transplant 13:691-9. 2004
    ..This study demonstrated that cell transplantation to the salivary gland is feasible, and that the transplanted cells were selectively attracted to and remained in the damaged area without affecting normal tissue...
  37. pmc Transcriptomic analysis of the salivary glands of an invasive whitefly
    Yun Lin Su
    Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Sciences, Zhejiang University, Hangzhou, China
    PLoS ONE 7:e39303. 2012
    ..The primary salivary glands of whiteflies are critical for their feeding and virus transmission...
  38. pmc Anti-thrombosis repertoire of blood-feeding horsefly salivary glands
    Dongying Ma
    Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Mol Cell Proteomics 8:2071-9. 2009
    ..Little information is available on antihemostatic substances in horsefly salivary glands although their saliva has been thought to contain wide range of physiologically active molecules...
  39. pmc An insight into the sialotranscriptome of the brown dog tick, Rhipicephalus sanguineus
    Elen Anatriello
    Department of Maternal and Child and Public Health Nursing, Ribeirao Preto School of Nursing, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    BMC Genomics 11:450. 2010
    ..of 2,034 expressed sequence tags (EST) from two cDNA libraries, one consctructed using mRNA from dissected salivary glands from female ticks fed for 3-5 days (early to mid library, RsSGL1) and the another from ticks fed for 5 days (..
  40. ncbi Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands
    Xueqing Xu
    Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Mol Cell Proteomics 7:582-90. 2008
    ..Little information is available on antihemostatic substances in horsefly salivary glands; especially no horsefly immune suppressants have been reported...
  41. ncbi Isolation and characterization of adult stem cells from human salivary glands
    Nicole Rotter
    Department of Otorhinolaryngology, Ulm University, 89075 Ulm, Germany
    Stem Cells Dev 17:509-18. 2008
    ..Easy accessibility and a high differentiation potential make salivary gland-derived stem cells a promising source for future applications in regenerative medicine...
  42. pmc Platelet aggregation inhibitors from hematophagous animals
    Ivo M B Francischetti
    Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Toxicon 56:1130-44. 2010
    b>Salivary glands from blood-sucking animals (e.g., mosquitoes, bugs, sand flies, fleas, ticks, leeches, hookworms, bats) are a rich source of bioactive molecules that counteract hemostasis in a redundant and synergistic manner...
  43. pmc An insight into the sialome of Glossina morsitans morsitans
    Juliana Alves-Silva
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    BMC Genomics 11:213. 2010
    ..Adult tsetse flies feed exclusively on vertebrate blood and are important vectors of human and animal diseases. Thus far, only limited information exists regarding the Glossina sialome, or any other fly belonging to the Hippoboscidae...
  44. pmc Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis
    Gikas E Katsifis
    Oral Infection and Immunity Branch and Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, Bethesda, MD 20892, USA
    Am J Pathol 175:1167-77. 2009
    ..Plasma and minor salivary glands (MSGs) from patients with pSS were therefore evaluated for CD4(+) T cells, T regulatory cells, IL-17, and ..
  45. pmc OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 113:220-30. 2004
    ..burgdorferi invasion of tick salivary glands. We then generated ospC knockout spirochetes in an infectious clone of B...
  46. pmc Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicus
    Jitka Hostomska
    Charles University in Prague, Faculty of Science, Department of Parasitology, Vinicna 7, 128 44 Praha 2, Czech Republic
    BMC Genomics 10:282. 2009
    ..In the present work, we focused on Phlebotomus (Adlerius) arabicus, which was recently shown to transmit Leishmania tropica, the causative agent of cutaneous leishmaniasis in Israel...
  47. pmc B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome
    Marc Ittah
    Rhumatologie, Institut Pour la Santé et la Recherche Médicale INSERM U 802, Hopital Bicetre, Assistance Publique Hopitaux de Paris AP HP, Universite Paris Sud 11, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Arthritis Res Ther 8:R51. 2006
    ..The cellular origin of BAFF overexpression in salivary glands of patients with pSS is not fully known...
  48. ncbi A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands
    Andrea Pauli
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
    Curr Biol 20:1787-98. 2010
    ..These and other recent experimental findings have led to the suggestion that cohesin, in addition to its canonical function of mediating sister chromatid cohesion, might also be involved in regulating gene expression...
  49. pmc Transgene-mediated suppression of dengue viruses in the salivary glands of the yellow fever mosquito, Aedes aegypti
    G Mathur
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Insect Mol Biol 19:753-63. 2010
    ..Adult female salivary glands are involved in pathogen transmission to human hosts and are target sites for expression of antipathogen ..
  50. ncbi Proteomic analysis of salivary glands of female Anopheles barbirostris species A2 (Diptera: Culicidae) by two-dimensional gel electrophoresis and mass spectrometry
    Narissara Jariyapan
    Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand
    Parasitol Res 111:1239-49. 2012
    ..9 to 10. The proteome profiles of A. barbirostris species A2 female salivary glands were affected by aging...
  51. ncbi Two novel Salp15-like immunosuppressant genes from salivary glands of Ixodes persulcatus Schulze tick
    A Mori
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Insect Mol Biol 19:359-65. 2010
    ..Two cDNA clones encoding the Salp15-like sequence were obtained from salivary glands of fed female ticks...
  52. pmc Disruption of Plasmodium sporozoite transmission by depletion of sporozoite invasion-associated protein 1
    Sabine Engelmann
    Department of Parasitology, Heidelberg University School of Medicine, 69120 Heidelberg, Germany
    Eukaryot Cell 8:640-8. 2009
    Accumulation of infectious Plasmodium sporozoites in Anopheles spp. salivary glands marks the final step of the complex development of the malaria parasite in the insect vector...
  53. ncbi The r131 gene of rat cytomegalovirus encodes a proinflammatory CC chemokine homolog which is essential for the production of infectious virus in the salivary glands
    Suzanne J F Kaptein
    Department of Medical Microbiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 5800, 6202 AZ, The Netherlands
    Virus Genes 29:43-61. 2004
    ..in contrast to WT virus, neither RCMVdeltar131a nor RCMVdeltar131b established a high-titer infection in the salivary glands of immunocompromised rats...
  54. pmc Impact of salivary gland hypertrophy virus infection on the mating success of male Glossina pallidipes: consequences for the sterile insect technique
    Gratian N Mutika
    Insect Pest Control Laboratory, Joint FAO IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, Austria
    PLoS ONE 7:e42188. 2012
    ..pallidipes not only affects colony stability and performance but, in view of their reduced mating propensity and competitiveness, releasing SGH+ sterile male G. pallidipes will reduce the efficiency of a sterile male release programme...
  55. pmc Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis
    Jennifer L Avila
    Department of Physiological Sciences, University of Arizona, Tucson, AZ, USA
    Int J Radiat Oncol Biol Phys 73:523-9. 2009
    Radiotherapy for head-and-neck cancer causes adverse secondary side effects in the salivary glands and results in diminished quality of life for the patient...
  56. ncbi Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren's syndrome patients is linked to ectopic mucin secretion
    María José Barrera
    Faculty of Medicine, Institute of Biomedical Sciences ICBM, University of Chile, Postal Code 8389100, Santiago, Chile
    J Autoimmun 39:83-92. 2012
    Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease that mainly affects tear and salivary glands, whereby SS-patients frequently complain of eye and mouth dryness...
  57. pmc Location of immunization and interferon-γ are central to induction of salivary gland dysfunction in Ro60 peptide immunized model of Sjögren's syndrome
    Hongen Yin
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e18003. 2011
    ..The aim of this study was to investigate factors involved in salivary gland (SG) dysfunction after immunization and to test whether the induction of SS could be improved...
  58. ncbi Salivary gland epithelial cell exosomes: A source of autoantigenic ribonucleoproteins
    Efstathia K Kapsogeorgou
    National University of Athens, Athens, Greece
    Arthritis Rheum 52:1517-21. 2005
    ....
  59. ncbi Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands
    Isabelle M A Lombaert
    Section of Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 12:1804-12. 2006
    ..Here, we assessed the potential of granulocyte colony-stimulating factor (G-CSF)-mobilized bone marrow-derived cells (BMC) to regenerate and functionally restore irradiated salivary glands used as a model for normal tissue damage.
  60. ncbi On the mechanism of salivary gland radiosensitivity
    Antonius W T Konings
    Department of Radiation and Stress Cell Biology, University of Groningen, Building 3215 5th Floor, Ant Deusinglaan 1, 9717 BM Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 62:1187-94. 2005
    To contribute to the understanding of the enigmatic radiosensitivity of the salivary glands by analysis of appropriate literature, especially with respect to mechanisms of action of early radiation damage, and to supply information on ..
  61. pmc Sensitivity of salivary glands to radiation: from animal models to therapies
    O Grundmann
    Department of Nutritional Sciences, University of Arizona, 1177 E 4th St, Shantz 421, PO Box 210038, Tucson, AZ 85721, USA
    J Dent Res 88:894-903. 2009
    Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals...
  62. pmc Apoptosis in mosquito salivary glands: Sindbis virus-associated and tissue homeostasis
    Erica M Kelly
    Departments of Physics and Biology, 1 UNF Drive, University of North Florida, Jacksonville, FL 32224, USA
    J Gen Virol 93:2419-24. 2012
    ....
  63. pmc Molecular and pharmacological characterization of serotonin 5-HT2α and 5-HT7 receptors in the salivary glands of the blowfly Calliphora vicina
    Claudia Röser
    Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany
    PLoS ONE 7:e49459. 2012
    Secretion in blowfly (Calliphora vicina) salivary glands is stimulated by the biogenic amine serotonin (5-hydroxytryptamine, 5-HT), which activates both inositol 1,4,5-trisphosphate (InsP(3))/Ca(2+) and cyclic adenosine 3',5'-..
  64. pmc Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands
    Lei Liu
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, PO Box 208022, New Haven, Connecticut 06520 8022, USA
    EMBO Rep 12:1196-203. 2011
    ..The bacteria then migrate from the gut to infect the salivary glands of the ticks and are transmitted to the next host via the saliva...
  65. ncbi Regeneration of radiation damaged salivary glands with adipose-derived stromal cells
    Tsuyoshi Kojima
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Laryngoscope 121:1864-9. 2011
    ..development of dry mouth syndrome is an unavoidable side effect because, in addition to the tumor, the normal salivary glands are included in the irradiation field...
  66. pmc Differential expression of genes in salivary glands of male Rhipicephalus (Boophilus)microplus in response to infection with Anaplasma marginale
    Zorica Zivkovic
    Department of Infectious Diseases and Immunology, Utrecht Centre for Tick borne Diseases UCTD, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    BMC Genomics 11:186. 2010
    ..A. marginale undergoes a complex developmental cycle in ticks which results in infection of salivary glands from where the pathogen is transmitted to cattle...
  67. ncbi Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?
    Anke Petra Jellema
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 77:164-71. 2005
    ..To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva...
  68. ncbi Transdifferentiation of bone marrow stem cells into acinar cells using a double chamber system
    Chia Yung Lin
    Graduate Institute of Clinical Dentistry, School of Dentistry, Taipei, Taiwan
    J Formos Med Assoc 106:1-7. 2007
    Hypofunction of the salivary glands can substantially affect quality of life. Current treatments for salivary hypofunction are of limited effectiveness...
  69. ncbi A proteomic analysis of salivary glands of female Anopheles gambiae mosquito
    Dario E Kalume
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Proteomics 5:3765-77. 2005
    ..Therefore, we carried out a proteomic analysis of salivary glands from female An. gambiae mosquitoes...
  70. pmc New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome
    H Tsuboi
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Clin Exp Immunol 162:53-61. 2010
    M3 muscarinic acetylcholine receptor (M3R) plays a crucial role in the secretion of saliva from salivary glands. It is reported that some patients with Sjögren's syndrome (SS) carried inhibitory autoantibodies against M3R...
  71. ncbi Studies on the role of the minor capsid protein in transport of Beet western yellows virus through Myzus persicae
    C Reinbold
    INRA, 28 rue de Herrlisheim, 68021 Colmar Cedex, France
    J Gen Virol 82:1995-2007. 2001
    ....
  72. ncbi Human mesenchymal stem cells cultured with salivary gland biopsies adopt an epithelial phenotype
    Ola M Maria
    Faculty of Dentistry, McGill University, Montreal, Canada
    Stem Cells Dev 20:959-67. 2011
    ..Moreover, the amounts of α-AMY detected in cocultured MSCs were comparable to those detected in huSGs control cultures. These data suggest that cocultured MSCs can demonstrate a temporary change into a salivary gland acinar phenotype...
  73. ncbi Blocking malaria parasite invasion of mosquito salivary glands
    Anthony A James
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    J Exp Biol 206:3817-21. 2003
    ..The use of a number of synthetic genes based on different mechanisms in transgenic mosquitoes will make the selection of resistant parasites unlikely...
  74. pmc Transcriptomic and functional analysis of the Anopheles gambiae salivary gland in relation to blood feeding
    Suchismita Das
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205 2179, USA
    BMC Genomics 11:566. 2010
    The Anopheles gambiae salivary glands play a major role in malaria transmission and express a variety of bioactive components that facilitate blood-feeding by preventing platelet aggregation, blood clotting, vasodilatation, and ..
  75. pmc Microchimerism in salivary glands after blood- and marrow-derived stem cell transplantation
    Simon D Tran
    Faculty of Dentistry, McGill University, Montreal, Canada
    Biol Blood Marrow Transplant 17:429-33. 2011
    ..all recipients exhibited scattered Y chromosome-positive cells in the acini, ducts, and stroma of their salivary glands (mean of 1.01%)...
  76. pmc Activation of autophagy during cell death requires the engulfment receptor Draper
    Christina K McPhee
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 465:1093-6. 2010
    ..Drosophila salivary glands undergo programmed cell death that requires autophagy genes, and engulfment of salivary gland cells by ..
  77. pmc Role for Notch signaling in salivary acinar cell growth and differentiation
    Howard Dang
    The University of Texas Health Science Center, Department of Community Dentistry, San Antonio, Texas, USA
    Dev Dyn 238:724-31. 2009
    ..Taken together, these data suggest that Notch signaling is critical for normal salivary gland cell growth and differentiation...
  78. ncbi Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression
    Shinya Yamamoto
    Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:23139-49. 2008
    ..Thus, PDGF signaling is a possible mechanism involved in the interaction between epithelial and neural crest-derived mesenchyme...
  79. ncbi Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva
    M Murakami
    Division of Dermatology, University of California San Diego, USA
    J Dent Res 81:845-50. 2002
    ..CRAMP mRNA and protein were localized to the salivary glands, specifically in acinar cells of the submandibular gland and palatine minor glands, as well as in lingual ..
  80. pmc Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1190, USA
    Clin Cancer Res 17:2842-51. 2011
    b>Salivary glands are significantly affected when head and neck cancer patients are treated by radiation...
  81. ncbi Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase
    Na Xu
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Dev Biol 321:88-100. 2008
    ..Our genetic and live-imaging analyses provide novel evidence that the proximal gland cells play an essential and active role in salivary gland migration that propels the entire gland to turn and migrate posteriorly...
  82. pmc Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration
    Oliver Grundmann
    Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA
    BMC Cancer 10:417. 2010
    ..To address this problem we investigated the potential for post-therapeutic IGF-1 to reverse radiation-induced salivary gland dysfunction...
  83. ncbi Isolation, tissue localization, and cellular characterization of progenitors derived from adult human salivary glands
    Ayumi Sato
    Department of Pediatrics, Kumamoto University School of Medicine, Kumamoto, Japan
    Cloning Stem Cells 9:191-205. 2007
    ..into cells with hepatic or pancreatic phenotypes can be isolated from experimentally injured salivary glands of rodents...
  84. ncbi Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands
    Masashi Shimozuma
    Second Department of Oral and Maxillofacial Surgery, Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2 1 3 Tsurumi, Tsurumi ku, Yokohama, Kanagawa, Japan
    Histochem Cell Biol 135:389-96. 2011
    ..The present study was performed to investigate where melatonin was synthesized and whether it was secreted by salivary glands into saliva...
  85. ncbi Plasmodium differentiation in the mosquito
    R E Sinden
    Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
    Parassitologia 41:139-48. 1999
    ..The potential exploitation of these interactions as possible mechanisms for intervention will be discussed...
  86. ncbi cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland
    S Sanghi
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    J Mol Biol 310:127-39. 2001
    ..Lacritin mRNA and protein are highly expressed in human lacrimal gland, moderately in major and minor salivary glands and slightly in thyroid...
  87. pmc Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
    Arjan Vissink
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Grongingen, The Netherlands
    Int J Radiat Oncol Biol Phys 78:983-91. 2010
    ..These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy...
  88. pmc Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 204:1217-25. 2007
    The salivary glands represent a major site of cytomegalovirus replication and transmission to other hosts...
  89. pmc Coupling genetics and proteomics to identify aphid proteins associated with vector-specific transmission of polerovirus (luteoviridae)
    Xiaolong Yang
    Department of Plant Pathology, Cornell University, Ithaca, NY 14853, USA
    J Virol 82:291-9. 2008
    ....
  90. pmc Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and mice
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Arthritis Rheum 58:734-43. 2008
    ..Importantly, Th17 cells appear to be intimately involved in autoimmunity. We undertook the present study to investigate whether the Th17/IL-23 system is up-regulated in Sjögren's syndrome (SS)...
  91. pmc Tsetse salivary gland hypertrophy virus: hope or hindrance for tsetse control?
    Adly M M Abd-Alla
    Insect Pest Control Laboratory, Joint FAO IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria
    PLoS Negl Trop Dis 5:e1220. 2011
    ..In addition, preliminary attempts to silence the expression of an essential viral protein using RNA interference will be discussed...
  92. pmc Genome analysis of a Glossina pallidipes salivary gland hypertrophy virus reveals a novel, large, double-stranded circular DNA virus
    Adly M M Abd-Alla
    Entomology Unit, FAO IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories, A 2444 Seibersdorf, Austria
    J Virol 82:4595-611. 2008
    ..Furthermore, no homologues to DNA-dependent RNA polymerase subunits were detected. Taken together, these data indicate that GpSGHV is the prototype member of a novel group of insect viruses...
  93. pmc Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate
    Michele Bombardieri
    Rheumatology Department, GKT School of Medicine, King s College London, UK
    Arthritis Res Ther 6:R447-56. 2004
    ..IL-18 expression in SS salivary glands was detected in 28 of 32 periductal foci of mononuclear cells (87...
  94. pmc An insight into the sialotranscriptome of the seed-feeding bug, Oncopeltus fasciatus
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    Insect Biochem Mol Biol 37:903-10. 2007
    ..Finally, several novel putative proteins are described with no known function that might affect plant physiology or act as antimicrobials...
  95. ncbi Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome
    M E Wildenberg
    Department of Immunology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Ann Rheum Dis 68:420-6. 2009
    In the salivary glands of patients with primary Sjögren Syndrome (pSjS) an accumulation of dendritic cells (DCs) is seen, which is thought to play a role in stimulating local inflammation...
  96. pmc Cytokines in Sjögren's syndrome
    N Roescher
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Oral Dis 15:519-26. 2009
    ..In the salivary glands, saliva and serum of these patients, many pro-inflammatory cytokines are upregulated...
  97. ncbi Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins
    R J Nascimento
    Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, , Federal District, Brazil
    Am J Trop Med Hyg 65:219-26. 2001
    ..In conclusion, IgG1 reactive against TSGP is the main antibody present in individuals living in the triatomine-infested study areas. Also, IgG4 is found in the sera of insect-transmitted Chagas disease patients living in study areas...
  98. pmc Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome
    Jelle L Vosters
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 60:3633-41. 2009
    ..Our secondary objective was to further characterize this animal model and to determine if the changes observed in these mice are representative of those observed in patients with SS overall...
  99. ncbi Autoimmune response and target autoantigens in Sjogren's syndrome
    John G Routsias
    Department of Pathophysiology, School of Medicine, University of Athens, Greece
    Eur J Clin Invest 40:1026-36. 2010
    ..Primary Sjogren's syndrome (pSS) is characterized by the presence of autoantibodies targeting mainly the Ro/La ribonucleoprotein complex. It is now appreciated that the production of autoantibodies is an antigen-driven immune response...
  100. pmc The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
    Rebecca M Fox
    Department of Cell Biology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 191:479-92. 2010
    ..Finally, we found that the human CrebA orthologues, Creb3L1 and Creb3L2, have the ability to up-regulate the secretory pathway in nonsecretory cell types...
  101. ncbi The treatment of drooling by ultrasound-guided intraglandular injections of botulinum toxin type A into the salivary glands
    Peter H Jongerius
    Department of Rehabilitation, University Medical Center St Radboud, Nijmegen, The Netherlands
    Laryngoscope 113:107-11. 2003
    The aim of the study was to present the background, procedure, and technique of bilateral ultrasound-guided, single-dose injections of botulinum toxin type A (BTX) into the salivary glands in patients with severe drooling.

Research Grants76

  1. PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROME
    SAMUEL HOPKINS; Fiscal Year: 2005
    ..Over time, progressive infiltration of lacrimal and salivary glands by mononuclear cells leads to diminished secretions, with resultant xerostomia (dry mouth) and xeropthalmia (..
  2. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    ..To develop techniques for the successful regeneration of salivary glands in vivo, it is first necessary to understand signaling pathways that regulate gland development, which ..
  3. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..frequently causes significant side effects in the surrounding oral mucosa (blistering/mucositis) and salivary glands (dry mouth/xerostomia)...
  4. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..Furthermore, analysis of the development of mosquito salivary glands, which are essential for the spread of infection, could lead to creation of additional means of controlling ..
  5. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..Once in the hemocoel, the bacterium must navigate towards the salivary glands, attach to the acinar surface, penetrate the basal lamina, and enter the salivary ducts. B...
  6. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..From this focus of infection, the hemocoel and eventually the salivary glands become infected, owing to the highly invasive nature of Bb, and that the resulting infection is life-long and ..
  7. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..A. phagocytophilum and B. microti infect the salivary glands of the tick, hence poised to exit the tick vector during feeding. On the other hand, B...
  8. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..cellular functions of Orai1 have been identified in lymphocytes, mast cells, blood platelets, sweat and salivary glands, dentition, vascular smooth muscle, endothelial cells, and skeletal muscle...
  9. VEE Virus Infection on the Mosquito Vector
    Scott C Weaver; Fiscal Year: 2013
    ..midgut, believed to be the portal of entry, as well as downstream target tissues and organs including the salivary glands. These viruses and replicon particles will also be used to characterize the barriers to infection and ..
  10. Tousled kinase contributes to survival of salivary acinar cells against radiation
    Gulshan Sunavala-Dossabhoy; Fiscal Year: 2013
    ..The unintended destruction of normal salivary glands causes a dramatic drop in saliva production, leading to a condition referred to as xerostomia or dry mouth...
  11. Oral Mucins as a Diagnostic Indicator and Therapeutic Treatment for Xerostomia
    DAVID JOHN CULP; Fiscal Year: 2011
    ..In saliva, secretions from salivary glands contribute at least two mucins...
  12. Identification and Characterization of Adult Salivary Gland Stem Cells
    Soosan Ghazizadeh; Fiscal Year: 2013
    ..These are central issues from the perspective of regenerative medicine targeted to salivary glands. In this regard, our laboratory was first to develop a method for in situ lineage tracing that we used to ..
  13. PKCdelta and Salivary Gland Apoptosis
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..how apoptosis is regulated in salivary gland cells is critical for the development of therapeutics to protect salivary glands from irradiation induced damage and for the treatment of Sjogren's syndrome, salivary tumors and other ..
  14. A Novel Therapy for Radiation-Induced Xerostomia Using Human Salivary Stem Cells
    QUYNH THU XUAN LE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The project aims to isolate stem cells from human salivary glands and to determine the optimal drug and growth factor combination to increase stem cell enrichment and facilitate their engraftment and ..
  15. SODIUM ENTRY INTO AMILORIDE-SENSITIVE EPITHELIA
    Catherine M Fuller; Fiscal Year: 2013
    ..Epithelial sodium channels (ENaC) have been found in other sodium transportinmg epithelia, e.g., salivary glands, colon, bronchial and tracheal epithelia, as well as in many non-epithelial cells, like lymphocytes, neurons ..
  16. MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSION
    David K Ann; Fiscal Year: 2013
    ..We postulate that autophagy protects salivary glands from stress and pathologic insults by promoting acinar cell survival and regeneration as a stress adaptation ..
  17. Identification of bacterial genes required for transmission of tick-borne pathoge
    Susan M Noh; Fiscal Year: 2012
    ..entry into and replication within radically different host cell types including cells of the tick midgut and salivary glands. Through transcriptomics and proteomics, pathogen proteins specifically up-regulated during tick colonization ..
  18. PROOF OF CONCEPT FOR ANTIMICROBIAL PROPERTIES OF LACRITIN IN VIVO
    John D Sheppard; Fiscal Year: 2010
    ..Lacritin, a novel human tear protein produced by lacrimal and salivary glands and by epithelial cells of the ocular surface, has multiple functions that encapsulate both areas...
  19. Immune-pathophysiology of lymphocytic foci in Sjogren's syndrome
    Cuong Q Nguyen; Fiscal Year: 2010
    ..proposed herein is to focus on defining the nature of the leukocyte populations forming within LF of the salivary glands and determine if these cell populations identify disease mechanisms involved in SjS autoimmunity...
  20. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2013
    ..that resides in 2 different locations during its life cycle -- mammalian neutrophils and Ixodes scapularis salivary glands. This project investigates whether tick genes that are up- or down-regulated in the presence of A...
  21. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    Jacques U Baenziger; Fiscal Year: 2010
    ..on LH and other pituitary glycoproteins are also found on glycoproteins produced in the brain, kidney, salivary glands, and other tissues...
  22. Mechanisms of IGF-1 mediated rescue of radiation-induced salivary gland dysfuncti
    Kirsten H Limesand; Fiscal Year: 2012
    ..However, salivary glands convey the opposite characteristics with a low level of proliferation and high level of differentiation ..
  23. Multi-stage multi-antigen Vaccine for interrupting Malaria Transmission
    B Kim Lee Sim; Fiscal Year: 2013
    ..and thus our strategy would also target the conversion of oocysts to infectious sporozoites in the salivary glands. We will study the three proteins as immunogens alone and in combination, aiming to induce 100% transmission ..
  24. HCO3- Conductive function of CFTR: Implications to Oral Health & Cystic Fibrosis
    MADIREDDI REDDY; Fiscal Year: 2010
    ..provided by applicant): Bicarbonate is a vital component of secretions from exocrine glands such as salivary glands, pancreas, duodenum, reproductive organs, sweat glands and the airways...
  25. Malaria transmission potential of the Anopheles punctutatus species complex
    Lisa Reimer; Fiscal Year: 2013
    ..will be monitored by recording both oocyst densities in the midgut as well as sporozoite densities in the salivary glands. In addition, since mixed Plasmodium infections are common in human and mosquito populations, the secondary ..
  26. EXPRESSION OF EXOGENOUS GENES IN VECTOR MOSQUITOES
    Anthony A James; Fiscal Year: 2013
    ..and mean intensities of infection (average number of parasites in only those mosquitoes infected) in the salivary glands of parasite-challenged mosquitoes...
  27. Poly(ADP-ribose)Polymerase 1 Regulates Nucleolar Structure and Functions
    ERNEST KOJO BOAMAH; Fiscal Year: 2012
    ..utilize confocal microscopy and immunofluorescence to examine localization of nucleolar specific proteins in salivary glands from Drosophila larvae with compromised PARP1 activity...
  28. Mechanisms of FGFR2 Signaling in Salivary Gland Branching Morphogenesis
    Veraragavan P Eswarakumar; Fiscal Year: 2013
    ..However, the lack of salivary glands in Fgf10 or Fgfr2b knockout mice precludes further investigation of branching morphogenesis in these mouse ..
  29. array-based screening for the expression and regulation of tumor supressor genes
    PATRICK KYONGMIN HA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adenoid cystic carcinoma of the salivary glands (ACC) is a rare malignancy with an unusual clinical behavior, marked by aggressive local growth which is often controlled with surgery and ..
  30. Immuno-pathophysiology of Lymphocytic Foci in Sjogren?s Syndrome
    Cuong Q Nguyen; Fiscal Year: 2013
    ..specific aims will be carried out: 1) characterizing individual IL-22-secretlng cells infiltrating the labial salivary glands (LSG) of SjS patients, and 2) identifying the T cell receptor (TCR)-P gene rearrangement of Individual IL-22 ..
  31. Autophagy & Functional Restoration of Irradiated Salivary Glands
    KIRSTEN H contact LIMESAND; Fiscal Year: 2010
    ..Challenge Area (15) Translational Science and specific Challenge Topic, 15-DE-104 Functional Restoration of Salivary Glands. Proper salivary gland function is critical for oral health...
  32. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2013
    ..Histatins are a family of histidine-rich cationic proteins secreted by major salivary glands that contribute significantly to the antifungal activity of saliva...
  33. Mucosal Therapy for Autoimmunity
    David W Pascual; Fiscal Year: 2013
    ..and to design a regimen that can prevent and/or treat autoimmune diseases or allergies of the oral cavity and salivary glands. The prevalence of Sj"gren's Syndrome is estimated at 2-4 million individuals, which represents the ..
  34. Modeling Dynamics of Salivary Gland Branching Morphogenesis
    Bulent Yener; Fiscal Year: 2012
    ..Existing strategies for engineering salivary glands have been unable to create a complex branched structure or successfully produce saliva-secreting acinar cells,..
  35. Arbovirus midgut escape mechanisms
    A Lorena Passarelli; Fiscal Year: 2013
    ..replicate in the midgut cells of the vector and then spread to secondary tissues eventually reaching the salivary glands. Once the latter are infected, the arthropod is able to transmit the virus to a new host...
  36. PAR-1b in Integrin Localization and Laminin-111 Assembly in the Salivary Gland
    ELISE GERVAIS; Fiscal Year: 2013
    ..Sj[unreadable]gren's syndrome is an autoimmune disease that affects the exocrine glands, including the salivary glands and the lacrimal glands, decreasing secretory products (saliva and tears) and causing significant decreases ..
  37. A Genetic Model of NMDA Receptor Function in Cell Death
    Michael Lehmann; Fiscal Year: 2013
    ..Death of the larval salivary glands during metamorphosis, which constitutes an important model system in cell death research, fails when NMDAR ..
  38. Engineering Functioning Salivary Glands Using Micropatterned Scaffolds
    Melinda Larsen; Fiscal Year: 2010
    ....
  39. In vivo gene silencing in salivary glands
    Sven Ulrik Gorr; Fiscal Year: 2009
    ..The long-term goal of the proposed research is to use gene interference to modify the secretory machinery of salivary glands for targeted delivery of therapeutic proteins...
  40. Identification of Biomarkers in Sjogren's Syndrome
    IGNACIO E SANZ; Fiscal Year: 2010
    ..The diagnosis of SS currently relies on either the appearance of lymphocytic infiltration in labial minor salivary glands or of autoantibodies against Ro and La in the serum. However, disease severity, i.e...
  41. RNA METABOLISM IN TRYPANOSOMES
    Elisabetta Ullu; Fiscal Year: 2013
    ..and specifically about the signals that promote differentiation to epimastigote forms, migration to the salivary glands or the final differentiation step that results in infectious metacyclic forms...
  42. Gene therapy targeting the Th17 / IL-27 system in autoimmune exocrinopathy
    Ammon B Peck; Fiscal Year: 2010
    ..i) define and characterize the IL-23 secreting and CD4+ TH17 memory T cell populations infiltrating the salivary glands during development of SjS- like disease, and (ii) determine a possible regulatory potential of IL-27 on the ..
  43. Novel Mechanisms of Chronic Inflammation in Sjogren's Syndrome
    GARY ANDREW WEISMAN; Fiscal Year: 2010
    ..syndrome (SS) is an autoimmune disorder characterized by inflammation and destruction of lacrimal and salivary glands leading to decreased fluid secretion (xerostomia) often associated with lymphocytic infiltration of the ..
  44. Salivary Gland-Based Gene Therapy for Pulmonary Arterial Hypertension
    RAYMOND LOUIS BENZA; Fiscal Year: 2013
    ..this proposal toward achieving the field-wide goal of endogenous prostacyclin production is the choice of the salivary glands as the therapeutic biosynthesis site...
  45. Resolution of Cytokine-Mediated Salivary Gland Inflammation
    OLGA JULIANA BAKER; Fiscal Year: 2013
    ..We hypothesize that resolution of inflammation in salivary glands can prevent, and could help manage, symptoms of SS...
  46. Theoretical study of structure-function correlations of Aquaporin V and mutants
    LIAO Y CHEN; Fiscal Year: 2013
    ..human aquaporins (AQP0-AQP12) distributed within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear, AQP5 has been implicated in Sjogren's disease ..
  47. Adenosine Receptors and Restoration of Salivary Gland in Sjogren's Syndrome
    Umesh S Deshmukh; Fiscal Year: 2013
    ..Localized immunosuppression within the salivary glands will be studied by analyzing gene expression levels of different pro-inflammatory cytokines within the ..
  48. Genetic regulation of autophagic cell death
    Eric H Baehrecke; Fiscal Year: 2013
    ..An increase in steroid triggers a genetic hierarchy that activates nearly synchronous cell death in salivary glands. These developmentally-regulated cell deaths utilize apoptosis genes, including caspase proteases, but ..
  49. Expression and function of microRNA in autoimmune Sjogren's Syndrome
    Seunghee Cha; Fiscal Year: 2013
    ..The data were further supported by the findings in the salivary glands and PBMC of our pSjS-prone C57BL/6...
  50. Modulating Wnt and Hedgehog Pathways for Functional Restoration of Salivary Gland
    Fei Liu; Fiscal Year: 2010
    ..challenge area (15): Translational Science, and specific Challenge Topic 15-DE-104: Functional Restoration of Salivary Glands. Hypofunction of salivary gland is a common pathological condition in patients with Sj"gren's syndrome ..
  51. Regulation of SMG Development by Adhesion Receptors
    A Sue Menko; Fiscal Year: 2012
    ..Diseases of the salivary glands, including cancer and Sjogren's Syndrome, are characterized by the disruption of cell-matrix and cell-..
  52. Role of Vector antioxidant factors in Amblyomma-Rickettsia interaction
    Shahid Karim; Fiscal Year: 2012
    ..arthropod vectors, manipulate host homeostatic responses by secreting molecules from their multifunctional salivary glands. In their quest for a blood meal, ticks, and other blood-feeding arthropod vectors, transmit pathogens to ..
  53. Relapsing fever spirochete protein production within the vector
    Job E Lopez; Fiscal Year: 2013
    ..environments within the vector to continue their life-cycle, initially colonizing the midgut and thn the salivary glands, yet since RF spirochetes were first identified to cause human disease in 1905, two tick-associated proteins ..
  54. Functional Assembly of Salivary Cells to Relieve Xerostomia
    Robert Lee Witt; Fiscal Year: 2013
    ..in an animal model, to determine the host response to the HGP growth factors, the viability of the neo-salivary glands, and a functional assessment of saliva production, content, and quality...
  55. 2013 Salivary Glands and Exocrine Biology Gordon Research Conference
    Maria A Kukuruzinska; Fiscal Year: 2013
    ..provided by applicant): This proposal requests partial support for the ninth Gordon Research Conference on "Salivary Glands and Exocrine Biology" entitled From Development to Disease and Beyond, to be held February 3-8, 2013, at the ..
  56. SODIUM ENTRY INTO AMILORIDE-SENSITIVE EPITHELIA
    Dale Benos; Fiscal Year: 2009
    ..Epithelial sodium channels (ENaC) have been found in other sodium transporting epithelia, e.g., salivary glands, colon, bronchial and tracheal epithelia, as well as in many non-epithelial cells, like lymphocytes, neurons, ..
  57. Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)
    DAVID T contact WONG; Fiscal Year: 2010
    ..to validate the hypothesis that the pathogenesis of primary SS (pSS) and lymphoma (pSS/MALT) development in salivary glands involve the aberrant activities of key intracellular networks, pathways and molecular targets...
  58. An experimental/computational approach for understanding salivary fluid secretion
    David I Yule; Fiscal Year: 2012
    ..of the synergisms required among signaling pathways and effector molecules to modulate fluid production from salivary glands. We shall address this problem using a multi-scale mathematical and computational model...
  59. Non-coding RNAs in salivary gland tumor
    RUTHERFORD M ONGKEKO; Fiscal Year: 2013
    ..The first is to generate microRNA and lncRNA profiles in normal salivary glands, benign and malignant tumors to identify a panel of miRNAs that are differentially expressed among these ..
  60. Ultrasound-Assisted Gene Transfer of Anti-Biofilm Peptides to the Salivary Gland
    Michael J Passineau; Fiscal Year: 2012
    ..by applicant): The present proposal will optimize and apply a method for non-viral gene transfer to the salivary glands. This method utilizes low frequency ultrasound pulses to destroy microbubbles, causing local cavitation and ..
  61. Salivary Acinar Cell Apoptosis: Regulation of p53 by Akt
    Steven M Anderson; Fiscal Year: 2010
    ..Tissue-specific recombination will be used to eliminate mdm2 from the salivary glands of mice prior to treatment with IGF-1 and irradiation to confirm the pathway by which IGF-1 functions to ..
  62. A GENE-THERAPY BASED FUNCTIONAL RESTORATION OF SALIVARY GLANDS
    DAVID TERRY CURIEL; Fiscal Year: 2013
    ..a recombinant adenoviral vector (Ad) is employed to deliver the aquaporin gene to epithelial cells of the salivary glands via direct intra-ductal instillation...
  63. Mechanisms in Sjogrens Syndrome
    Antony Rosen; Fiscal Year: 2013
    ..syndrome, they are not always detected, despite universal lymphocytic infiltration of salivary glands. Our preliminary data shows that there are additional Sj[unreadable]gren's autoantigens recognized by ..
  64. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2006
    ..of poorly understood autoimmune or inflammatory diseases that affect different end organs including the eye, salivary glands, joints, and muscle...
  65. IL-4 Signaling Pathway Regulation of Sjogren's Syndrome
    AMMON PECK; Fiscal Year: 2004
    ..by exocrine dysfunction resulting from the action of1 a chronic autoimmune attack against the lacrimal and salivary glands. It is one of the leading causes of salivary gland inflammation and dysfunction, leading to severe dryness of ..
  66. Hyperbaric O2 Stimulation of Salivary Flow in Radiation -induced Xerostomia
    Michael Martin; Fiscal Year: 2009
    ..neck irradiation for cancer treatment due to the fibrosis and resultant decreased production of saliva by the salivary glands in the irradiated fields...
  67. ANTIVIRAL ACTIVITY OF THE IMMUNOSUPPRESSANT LEFLUNOMIDE
    W Waldman; Fiscal Year: 2004
    ..b>Salivary glands, spleen, and lungs will be examined histologically for viral pathology, and assayed for viral load by plaque ..
  68. XEROSTOMIA-INDUCING MECHANISMS OF PSYCHOTROPIC DRUGS
    JIA HUEY YU; Fiscal Year: 1993
    ..on secretory activities ( salivary flow, ion concentrations such as Na, K and Ca and amylase activity) of rat salivary glands in response to autonomic and autonomimetic stimulation...
  69. GENE EXPRESSION OF SALIVARY GLAND SPECIFIC GENES
    David Ann; Fiscal Year: 1993
    ..1) to understand why the expression of a given set of gene (proline-rich protein genes) is limited to the salivary glands; and (2) to determine how this expression is modulated in response to regulatory input from beta- agonist, ..
  70. MAXADILAN, A CUTANEOUS VASODILATOR FROM SAND FLIES
    Ethan Lerner; Fiscal Year: 2002
    Maxadilan is the most potent vasodilator known. It is a novel peptide recently isolated from salivary glands of the sand fly Lutzomyia longipalpis, a vector of the protozoan disease leishmaniasis...
  71. DEVELOPMENT OF CELL LINES FROM SUBLINGUAL GLANDS
    DAVID CULP; Fiscal Year: 1992
    ..secretory component of salivary mucous glands, such as the major sublingual gland and many of the minor salivary glands. Protective functions which have been attributed to mucins, include: 1) lubrication and hydration of oral ..
  72. Proteomics of mosquito immune response to malaria
    KENNETH VERNICK; Fiscal Year: 2003
    ..Sporozoites must migrate within hemolymph and invade the salivary glands in order for transmission to occur...
  73. MOLECULAR ANALYSIS OF HUMAN SALIVARY CYSTATIN GENES
    Douglas Dickinson; Fiscal Year: 1991
    The human salivary glands are specialized tissues that produce a number of different proteins involved in protection of the oral cavity...
  74. SALIVARY GLANDS AND THEIR INNERVATION IN DIABETES
    JACOB HANKER; Fiscal Year: 1980
    This project is to study the effects of diabetes mellitus on salivary glands and their innervation. Our previous studies have shown a decrease in size of the submandibular gland of the male mouse due to diabetes...
  75. SALIVARY GLAND TRANSGENIC MOUSE MODEL
    ELISA DURBAN; Fiscal Year: 1990
    ..Unexpectedly, this rare event resulted in WAP-Ha-ras expression only in the salivary glands of the male progeny who also developed salivary gland tumors within 8-15 months of age...
  76. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Douglas Darling; Fiscal Year: 2007
    ..of this research is to determine the mechanisms for sorting and storage of regulated secretory proteins in salivary glands. The answer to this question is important for our understanding of the regulation of protein secretion from ..