Genomes and Genes
Summary: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).
Publications314 found, 100 shown here
- Progression of salivary gland dysfunction in patients with Sjogren's syndromeJ Pijpe
University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
Ann Rheum Dis 66:107-12. 2007..Salivary gland dysfunction is one of the key manifestations of Sjögren's syndrome...
- The rôle of saliva in maintaining oral health and as an aid to diagnosisCarmen Llena-Puy
Department 9, Valencian Health Service, CEU Cardenal Herrera University
Med Oral Patol Oral Cir Bucal 11:E449-55. 2006Saliva is a complex secretion. 93% by volume is secreted by the major salivary glands and the remaining 7% by the minor glands. 99% of saliva is water and the other 1% is composed of organic and inorganic molecules...
- Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoesMa Isabel Salazar
Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
BMC Microbiol 7:9. 2007..must infect midgut epithelial cells, replicate and disseminate into the hemocoel, and finally infect the salivary glands, which is essential for transmission...
- Blood-feeding and immunogenic Aedes aegypti saliva proteinsLadawan Wasinpiyamongkol
Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Proteomics 10:1906-16. 2010..We have generated for the first time the 2-DE profiles of immunogenic Ae. aegypti SG BF-related proteins. These new data could contribute to the understanding of the physiological processes that appear during the blood meal...
- The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glandsMin Zhang
Michael Heidelberger Division, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 207:1465-74. 2010..the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host...
- Transcriptomic and functional analysis of the Anopheles gambiae salivary gland in relation to blood feedingSuchismita Das
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205 2179, USA
BMC Genomics 11:566. 2010The Anopheles gambiae salivary glands play a major role in malaria transmission and express a variety of bioactive components that facilitate blood-feeding by preventing platelet aggregation, blood clotting, vasodilatation, and ..
- Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and miceCuong Q Nguyen
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
Arthritis Rheum 58:734-43. 2008..Importantly, Th17 cells appear to be intimately involved in autoimmunity. We undertook the present study to investigate whether the Th17/IL-23 system is up-regulated in Sjögren's syndrome (SS)...
- Salivary gland protein repertoire from Aedes aegypti mosquitoesLionel Almeras
Unité de Recherche en Biologie et Epidémiologie Parasitaires UMR6236 IFR48, Institut de Médecine Tropicale du Service de Santé des Armées IMTSSA, Marseille, France
Vector Borne Zoonotic Dis 10:391-402. 2010..One hundred and twenty proteins were identified in these salivary glands representing the largest description of the Ae. aegypti salivary gland protein catalog...
- An insight into the sialome of the soft tick, Ornithodorus parkeriIvo M B Francischetti
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
Insect Biochem Mol Biol 38:1-21. 2008..As happens to all genera of blood-sucking arthropods, several new proteins were also found, indicating the process of adaptation to blood feeding still continues to recent times...
- The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune responseBradley S Schneider
Institut Pasteur, Departement de Parasitologie, Unités de Réponses Précoces aux Parasites et Immunopathologie, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Trans R Soc Trop Med Hyg 102:400-8. 2008..Compared with arbovirus infection initiated in the absence of the mosquito or its saliva, infection via mosquito saliva leads to an increase in virus transmission, host susceptibility, viraemia, disease progression and mortality...
- Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glandsXueqing Xu
Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
Mol Cell Proteomics 7:582-90. 2008..Little information is available on antihemostatic substances in horsefly salivary glands; especially no horsefly immune suppressants have been reported...
- Anti-thrombosis repertoire of blood-feeding horsefly salivary glandsDongying Ma
Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
Mol Cell Proteomics 8:2071-9. 2009..Little information is available on antihemostatic substances in horsefly salivary glands although their saliva has been thought to contain wide range of physiologically active molecules...
- An insight into the sialotranscriptome of the brown dog tick, Rhipicephalus sanguineusElen Anatriello
Department of Maternal and Child and Public Health Nursing, Ribeirao Preto School of Nursing, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
BMC Genomics 11:450. 2010..of 2,034 expressed sequence tags (EST) from two cDNA libraries, one consctructed using mRNA from dissected salivary glands from female ticks fed for 3-5 days (early to mid library, RsSGL1) and the another from ticks fed for 5 days (..
- Isolation and characterization of adult stem cells from human salivary glandsNicole Rotter
Department of Otorhinolaryngology, Ulm University, 89075 Ulm, Germany
Stem Cells Dev 17:509-18. 2008..Easy accessibility and a high differentiation potential make salivary gland-derived stem cells a promising source for future applications in regenerative medicine...
- Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesisGikas E Katsifis
Oral Infection and Immunity Branch and Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, Bethesda, MD 20892, USA
Am J Pathol 175:1167-77. 2009..Plasma and minor salivary glands (MSGs) from patients with pSS were therefore evaluated for CD4(+) T cells, T regulatory cells, IL-17, and ..
- Rescue of salivary gland function after stem cell transplantation in irradiated glandsIsabelle M A Lombaert
Section Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
PLoS ONE 3:e2063. 2008..Our approach is the first proof for the potential use of stem cell transplantation to functionally rescue salivary gland deficiency...
- Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in ThailandAmornrat Waitayakul
Department of Parasitology, Faculty of Medical Technology, Mahidol University, Salaya, Nakhonpathom, Thailand
Acta Trop 98:66-73. 2006..Immunohistochemical staining of Anopheles salivary glands with human sera showed that the salivary gland-specific IgGs reacted strongly with the median lobe...
- Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteinsR J Nascimento
Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, , Federal District, Brazil
Am J Trop Med Hyg 65:219-26. 2001..In conclusion, IgG1 reactive against TSGP is the main antibody present in individuals living in the triatomine-infested study areas. Also, IgG4 is found in the sera of insect-transmitted Chagas disease patients living in study areas...
- Autoimmune response and target autoantigens in Sjogren's syndromeJohn G Routsias
Department of Pathophysiology, School of Medicine, University of Athens, Greece
Eur J Clin Invest 40:1026-36. 2010..Primary Sjogren's syndrome (pSS) is characterized by the presence of autoantibodies targeting mainly the Ro/La ribonucleoprotein complex. It is now appreciated that the production of autoantibodies is an antigen-driven immune response...
- Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicusJitka Hostomska
Charles University in Prague, Faculty of Science, Department of Parasitology, Vinicna 7, 128 44 Praha 2, Czech Republic
BMC Genomics 10:282. 2009..In the present work, we focused on Phlebotomus (Adlerius) arabicus, which was recently shown to transmit Leishmania tropica, the causative agent of cutaneous leishmaniasis in Israel...
- Mosquito heparan sulfate and its potential role in malaria infection and transmissionPhotini Sinnis
Department of Medical Parasitology, New York University School of Medicine, New York, New York 10010, USA
J Biol Chem 282:25376-84. 2007..The glycosaminoglycans were isolated, from salivary glands and midguts of the mosquito in quantities sufficient for disaccharide microanalysis...
- Cytokines in Sjögren's syndromeN Roescher
Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Oral Dis 15:519-26. 2009..In the salivary glands, saliva and serum of these patients, many pro-inflammatory cytokines are upregulated...
- Genome analysis of a Glossina pallidipes salivary gland hypertrophy virus reveals a novel, large, double-stranded circular DNA virusAdly M M Abd-Alla
Entomology Unit, FAO IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories, A 2444 Seibersdorf, Austria
J Virol 82:4595-611. 2008..Furthermore, no homologues to DNA-dependent RNA polymerase subunits were detected. Taken together, these data indicate that GpSGHV is the prototype member of a novel group of insect viruses...
- An insight into the sialotranscriptome of the seed-feeding bug, Oncopeltus fasciatusIvo M B Francischetti
Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
Insect Biochem Mol Biol 37:903-10. 2007..Finally, several novel putative proteins are described with no known function that might affect plant physiology or act as antimicrobials...
- The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacityRebecca M Fox
Department of Cell Biology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
J Cell Biol 191:479-92. 2010..Finally, we found that the human CrebA orthologues, Creb3L1 and Creb3L2, have the ability to up-regulate the secretory pathway in nonsecretory cell types...
- Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrateMichele Bombardieri
Rheumatology Department, GKT School of Medicine, King s College London, UK
Arthritis Res Ther 6:R447-56. 2004..IL-18 expression in SS salivary glands was detected in 28 of 32 periductal foci of mononuclear cells (87...
- The treatment of drooling by ultrasound-guided intraglandular injections of botulinum toxin type A into the salivary glandsPeter H Jongerius
Department of Rehabilitation, University Medical Center St Radboud, Nijmegen, The Netherlands
Laryngoscope 113:107-11. 2003The aim of the study was to present the background, procedure, and technique of bilateral ultrasound-guided, single-dose injections of botulinum toxin type A (BTX) into the salivary glands in patients with severe drooling.
- An insight into the sialome of the adult female mosquito Aedes albopictusBruno Arcà
Department of Structural and Functional Biology, University Federico II, Naples, Italy
Insect Biochem Mol Biol 37:107-27. 2007To gain insight into the molecular repertoire of the adult female salivary glands of the tiger mosquito Aedes albopictus, we performed transcriptome and proteome analysis...
- Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndromeJelle L Vosters
National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA
Arthritis Rheum 60:3633-41. 2009..Our secondary objective was to further characterize this animal model and to determine if the changes observed in these mice are representative of those observed in patients with SS overall...
- An insight into the sialotranscriptome of the West Nile mosquito vector, Culex tarsalisEric Calvo
Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
BMC Genomics 11:51. 2010..quinquefasciatus, a mosquito relatively recently adapted to feed on humans, and the only mosquito of the genus Culex to have its sialotranscriptome so far described...
- Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndromeM E Wildenberg
Department of Immunology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Ann Rheum Dis 68:420-6. 2009In the salivary glands of patients with primary Sjögren Syndrome (pSjS) an accumulation of dendritic cells (DCs) is seen, which is thought to play a role in stimulating local inflammation...
- Dynamics of the salivary gland hypertrophy virus in laboratory colonies of Glossina pallidipes (Diptera: Glossinidae)Adly M M Abd-Alla
Insect Pest Control Laboratory, Joint FAO IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, Austria
Virus Res 150:103-10. 2010....
- The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjögren's syndromeCorinne Miceli-Richard
INSERM U 802, Universite Paris Sud 11, Le Kremlin Bicetre, France
Arthritis Rheum 60:1991-7. 2009....
- Lymphoplasmacytic infiltration of multiple organs with immunoreactivity for IgG4: IgG4-related systemic diseaseTakako Saeki
Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka
Intern Med 45:163-7. 2006..three elderly men with high serum IgG4 concentrations and multiple lymphoplasmacytic inflammation of the salivary glands, lymph nodes, pancreas, and renal interstitium...
- Ultrastructural study of West Nile virus pathogenesis in Culex pipiens quinquefasciatus (Diptera: Culicidae)Yvette A Girard
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA
J Med Entomol 42:429-44. 2005..and cell viability in midgut and salivary gland tissues, midguts were dissected on days 3, 7, 14, and 21, and salivary glands were collected on days 7, 14, 21, and 25 postinfection (d.p.i...
- Quantitative PCR analysis of the salivary gland hypertrophy virus (GpSGHV) in a laboratory colony of Glossina pallidipesAdly M M Abd-Alla
Entomology Unit, FAO IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories Seibersdorf, A 2444 Seibersdorf, Austria
Virus Res 139:48-53. 2009..68E+5, 2.05E+5 and 1.07E+7log(10) in DNA from an excised leg, salivary glands and a whole fly, respectively. In symptomatic flies the virus copy number in the same organs averaged 1...
- Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren's syndromeCapucine Daridon
Laboratory of Immunology, Brest University Medical School Hospital, Brest, France
Arthritis Rheum 56:1134-44. 2007To identify the cells that produce BAFF in the salivary glands of patients with primary Sjögren's syndrome (SS), and to analyze BAFF receptor expression by local T and B lymphocytes.
- Characterization of anti-hemostatic factors in the argasid, Argas monolakensis: implications for the evolution of blood-feeding in the soft tick familyBen J Mans
Laboratory for Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
Insect Biochem Mol Biol 38:22-41. 2008..This cross-reactivity could have facilitated the switching of soft ticks from avian to mammalian hosts and can explain in part the ability of Argas ticks, to feed on humans, thereby remaining a possible health risk...
- An immunoglobulin binding protein (antigen 5) of the stable fly (Diptera: Muscidae) salivary gland stimulates bovine immune responsesM Ameri
Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
J Med Entomol 45:94-101. 2008..These findings suggest that Ag5 of the stable fly salivary gland is not immunosuppressive but that it has immunoglobulin binding properties and can invoke specific antibody and memory lymphocyte responses in immunized calves...
- Species-specific antigens in salivary glands of phlebotomine sandfliesP Volf
Department of Parasitology, Charles University, Prague, Czech Republic
Parasitology 122:37-41. 2001..halepensis; in SGL from P. perliciosus, the sera from rabbits and hamsters bitten by this species recognized about 8 intense bands while sera from animals bitten by P. halepensis reacted weakly with up to 4 saliva polypeptides...
- Identification of abundant proteins and potential allergens in Culicoides nubeculosus salivary glandsA D Wilson
University of Bristol, School of Clinical Veterinary Science, Langford House, Langford, Bristol BS40 5DU, UK
Vet Immunol Immunopathol 122:94-103. 2008..Mass spectrometry identified two of these allergenic proteins as similar to hyaluronidase and a heavily glycosylated protein of unknown function that have previously been identified in salivary glands of C. sonorensis.
- Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine backgroundSeunghee Cha
University of Florida, Gainesville, FL 32610, USA
Arthritis Rheum 46:1390-8. 2002..In the present study, we bred the Idd3 and Idd5 chromosomal intervals from NOD mice into non-autoimmune C57BL/6 mice to determine if these intervals recreate a Sjögren's syndrome (SS)-like phenotype...
- Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patientsMichael K M Kam
State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
J Clin Oncol 25:4873-9. 2007..This randomized trial compared the rates of delayed xerostomia between two-dimensional radiation therapy (2DRT) and intensity-modulated radiation therapy (IMRT) in the treatment of early-stage nasopharyngeal carcinoma (NPC)...
- An insight into the sialome of Glossina morsitans morsitansJuliana Alves-Silva
Vector Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
BMC Genomics 11:213. 2010..Adult tsetse flies feed exclusively on vertebrate blood and are important vectors of human and animal diseases. Thus far, only limited information exists regarding the Glossina sialome, or any other fly belonging to the Hippoboscidae...
- Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infectionMathieu Dubrulle
Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
PLoS ONE 4:e5895. 2009..albopictus. As Ae. albopictus tends to replace Ae. aegypti in many regions, one question remained: is Ae. albopictus as efficient as Ae. aegypti to transmit the variant E1-226V of CHIKV?..
- Gene expression profiling of minor salivary glands clearly distinguishes primary Sjögren's syndrome patients from healthy control subjectsTrond Ove R Hjelmervik
Faculty of Dentistry, University of Bergen, Broegelmann Research Laboratory, University of Bergen, and Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Arthritis Rheum 52:1534-44. 2005To identify gene expression signatures in minor salivary glands (MSGs) from patients with primary Sjogren's syndrome (SS).
- The sialotranscriptome of the blood-sucking bug Triatoma brasiliensis (Hemiptera, Triatominae)Adriana Santos
Laboratório de Fisiologia de Insetos Hematófagos, Departamento de Parasitologia ICB, Universidade Federal de Minas Gerais, Caixa Postal 486, 31270 901, Belo Horizonte, MG, Brazil
Insect Biochem Mol Biol 37:702-12. 2007..Nine Kazal peptides were identified, among them one with high homology to the tabanid vasodilator vasotab, suggesting that the Triatoma vasodilator could be a Kazal protein...
- Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulationC M Krane
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
J Biol Chem 276:23413-20. 2001..These data show that AQP5 is the major pathway for regulating the water permeability in acinar cells, a critical property of the plasma membrane which determines the flow rate and ionic composition of secreted saliva...
- Oral sequelae of head and neck radiotherapyA Vissink
Department of Oral and Maxillofacial Surgery, University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
Crit Rev Oral Biol Med 14:199-212. 2003..g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints...
- The Anopheles gambiae salivary protein gSG6: an anopheline-specific protein with a blood-feeding roleFabrizio Lombardo
Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, Italy
Insect Biochem Mol Biol 39:457-66. 2009The Anopheles gambiae salivary gland protein 6 (gSG6) is a small protein specifically found in the salivary glands of adult female mosquitoes...
- Close relationship between autoimmune pancreatitis and multifocal fibrosclerosisT Kamisawa
Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
Gut 52:683-7. 2003..Autoimmune pancreatitis is a unique clinical entity proposed recently, and is sometimes associated with inflammation of other organs...
- Anopheles dirus co-infection with human and monkey malaria parasites in VietnamShusuke Nakazawa
Department of Protozoology, Institute of Tropical Medicine and the Global Center of Excellence Program, Nagasaki University, Japan
Int J Parasitol 39:1533-7. 2009..parasite DNA and specific mRNAs from wild-caught Anopheles dirus mosquitoes was assessed using dried mosquito salivary glands preserved on filter paper...
- The salivary glands as a privileged site of cytomegalovirus immune evasion and persistenceAnn E Campbell
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W Olney Road, Norfolk, VA 23507, USA
Med Microbiol Immunol 197:205-13. 2008The salivary glands (SG) provide a haven for persistent cytomegalovirus replication, and in this regard are a privileged site of virus immune evasion...
- An annotated catalog of salivary gland transcripts from Ixodes scapularis ticksJose M C Ribeiro
Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Insect Biochem Mol Biol 36:111-29. 2006..Results support the hypothesis that gene duplication, most possibly including genome duplications, is a major player in tick evolution...
- Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy backgroundRieko Arakaki
Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Am J Pathol 174:1715-24. 2009....
- AvGI, an index of genes transcribed in the salivary glands of the ixodid tick Amblyomma variegatumVishvanath Nene
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Int J Parasitol 32:1447-56. 2002Random clones from a cDNA library made from mRNA purified from dissected salivary glands of feeding female Amblyomma variegatum ticks were subjected to single pass sequence analysis...
- Lutzomyia longipalpis salivary gland homogenate impairs cytokine production and costimulatory molecule expression on human monocytes and dendritic cellsDirceu J Costa
, , Salvador, Bahia, Brazil
Infect Immun 72:1298-305. 2004..Finally, preincubating SGH with human sera containing anti-SGH-specific antibodies abolished the effects of SGH on cytokine production by LPS-stimulated monocytes...
- Dengue viruses binding proteins from Aedes aegypti and Aedes polynesiensis salivary glandsVan Mai Cao-Lormeau
Laboratoire de Recherche en Virologie Médicale, Institut Louis Malarde, PO Box 30, 98713 Papeete, Tahiti, French Polynesia
Virol J 6:35. 2009..Infection of vector salivary glands and further injection of infectious saliva into the human host are key events of the DENV transmission cycle...
- Sialadenitis histologically resembling Sjogren syndrome in mice transgenic for hepatitis C virus envelope genesK Koike
First Department of Internal Medicine, University of Tokyo, Japan
Proc Natl Acad Sci U S A 94:233-6. 1997..genes have been shown previously to express the HCV envelope proteins in organs, including the liver and salivary glands, which results in no pathological changes in the liver...
- A sicca syndrome in HIV infection: association with HLA-DR5 and CD8 lymphocytosisS Itescu
Hospital for Joint Diseases, New York, NY 10003
Lancet 2:466-8. 1989..In patients with this diffuse infiltrative lymphocytosis syndrome (DILS) the CD8 lymphocytosis, which probably depends on histocompatibility antigen status, may influence disease progression in HIV infection...
- A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesisD Ma
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
Thromb Haemost 105:1032-45. 2011..The RGD motif in the unique sequence of Tablysin-15 represents a novel template for studying the structure-function relationship of the disintegrin family of inhibitors...
- Mosquito salivary gland protein preservation in the field for immunological and biochemical analysisA Fontaine
Unité de Recherche en Biologie et Epidémiologie Parasitaires UMR6236 IFR48, Antenne Marseille de l Institut de Recherche Biomédicale des Armées, Le Pharo, BP 60109, 13 262 Marseille Cedex 07, France
Parasit Vectors 4:33. 2011..saliva collection is extremely laborious and inefficient, most research groups prefer to work on mosquito salivary glands (SGs)...
- Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sjogren's syndromeR Hal Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Immunol 175:8409-14. 2005..b>Salivary glands were collected and examined by histology after H&E staining...
- The lysozyme locus in Drosophila melanogaster: different genes are expressed in midgut and salivary glandsP Kylsten
Department of Molecular Biology, Stockholm University, Sweden
Mol Gen Genet 232:335-43. 1992..The LysP gene is only active in the adult where it is expressed in the salivary glands. The transcription units for both genes are very compact and they lack introns...
- Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glandsSeshagiri R Nandula
National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 56:1798-805. 2007..The aim of this study was to delineate the precise function of TGFbeta signaling in salivary gland inflammation...
- Drug effects on salivary glands: dry mouthC Scully
International Centres for Excellence in Dentistry and Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, UK
Oral Dis 9:165-76. 2003..To identify drugs associated with the complaint of dry mouth...
- The salivary glands and saliva of Anopheles gambiae as an essential step in the Plasmodium life cycle: a global proteomic studyValérie Choumet
Unité de Biochimie et de Biologie Moléculaire des Insectes, Institut Pasteur, Paris Cedex 15, France
Proteomics 7:3384-94. 2007Proteins synthesized in the salivary glands of the Anopheles gambiae mosquito are thought to be important in the life cycle of the malaria parasite Plasmodium. To describe A...
- Selective down-regulation of aquaporin-1 in salivary glands in primary SjÃ¶gren's syndromeDimitra Beroukas
Department of Immunology, Allergy, and Arthritis, Flinders Medical Centre and Flinders University, Bedford Park, Australia
Lab Invest 82:1547-52. 2002..We therefore conclude that AQP-1 expression in myoepithelial cells is selectively down-regulated in pSS and that myoepithelial cell dysfunction may play a crucial role in the pathology of this disease...
- Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genesD J Andrew
Department of Developmental Biology, Stanford University School of Medicine, CA 94305 5427
EMBO J 13:1132-44. 1994..Ultrabithorax (Ubx) and abdominal-A (abd-A), have no effect on the ability of Scr to direct the formation of salivary glands. Instead, salivary gland induction by Scr is limited in the trunk by the homeotic gene teashirt (tsh) and in ..
- Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatinJan Peter Siebrasse
Institute for Physical and Theoretical Chemistry, Wegelerstrasse 12, Rheinische Friedrich Wilhelms University Bonn, D 53115 Bonn, Germany
Proc Natl Acad Sci U S A 105:20291-6. 2008..We propose that the observed discontinuous movement reflects transient interactions between freely diffusing BR particles and these submicroscopic structures...
- Proteomic analysis of Glossina pallidipes salivary gland hypertrophy virus virions for immune intervention in tsetse fly coloniesHenry M Kariithi
Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands
J Gen Virol 91:3065-74. 2010..This result suggests that immune intervention of viral infections in colonies of G. pallidipes is a realistic option...
- Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren's syndromeYrjo T Konttinen
Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, Helsinki, Finland
J Rheumatol 32:1071-5. 2005..To localize aquaporin-5 in healthy salivary gland acinar cells and to check if it is abnormally translocated in an experimental NOD mouse model for Sjögren's syndrome (SS)...
- POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glandsE Moller
Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
J Pathol 215:78-86. 2008..and POU5F1 in two types of epithelial tumours: hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. This finding not only broadens considerably the spectrum of neoplasms associated with EWSR1 fusion genes but ..
- Invasion of mosquito salivary glands by malaria parasites: prerequisites and defense strategiesAnn Kristin Mueller
Parasitology Unit, Department of Infectious Diseases, Heidelberg University School of Medicine, 69120 Heidelberg, Germany
Int J Parasitol 40:1229-35. 2010..often needs to overcome several physical barriers, such as the peritrophic matrix, midgut epithelium and salivary glands. Additionally, the arthropod vector elicites immune responses that can severely limit transmission success...
- Identity and synthesis of prostaglandins in the lone star tick, Amblyomma americanum (L.), as assessed by radio-immunoassay and gas chromatography/mass spectrometryMajd Aljamali
Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 Noble Research Center, Stillwater, OK 74078-3035, USA
Insect Biochem Mol Biol 32:331-41. 2002..identified by radio-immunoassay (RIA) and/or gas chromatography/mass spectrometry (GC/MS) in the hemolymph, salivary glands and saliva of the lone star tick Amblyomma americanum (L.)...
- Gene expression profile in the salivary glands of primary Sjögren's syndrome patients before and after treatment with rituximabValerie Devauchelle-Pensec
Hopital de la Cavale Blanche, Centre Hospitalier Universitaire Brest, and Hôpital Morvan, Brest, France
Arthritis Rheum 62:2262-71. 2010..This open-label study was undertaken to evaluate the efficacy of rituximab in primary SS and to investigate whether expression of specific genes is associated with efficacy of this treatment...
- Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 miceUmesh S Deshmukh
University of Virginia, Charlottesville, VA 22908, USA
Arthritis Rheum 58:1318-23. 2008..This study was undertaken to determine whether induction of systemic inflammation accelerates the development of Sjögren's syndrome (SS) in genetically susceptible mice...
- Transcriptome changes in Culex quinquefasciatus (Diptera: Culicidae) salivary glands during West Nile virus infectionYvette A Girard
Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
J Med Entomol 47:421-35. 2010..the mosquito Culex quinquefasciatus Say (Diptera: Culicidae) is associated with pathological changes in the salivary glands, including apoptotic cell death and a corresponding reduction in virus transmission over time...
- Systemic increase in type I interferon activity in Sjögren's syndrome: a putative role for plasmacytoid dendritic cellsManon E Wildenberg
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
Eur J Immunol 38:2024-33. 2008In the salivary glands of primary Sjögren's syndrome (pSjS) patients, type I IFN activity is increased, but systemic levels of type I IFN proteins are rarely detected...
- Tick salivary glands: function, physiology and futureA S Bowman
School of Biological Sciences Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, Scotland, UK
Parasitology 129:S67-81. 2004The salivary glands are the organs of osmoregulation in ticks and, as such, are critical to the biological success of ticks both during the extended period off the host and also during the feeding period on the host...
- Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid miceL Kong
Department of Medicine, University of Texas Health Science Center, San Antonio, USA
Clin Exp Rheumatol 16:675-81. 1998....
- Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeuticsAntonis Voutetakis
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:3053-8. 2004..To circumvent such issues, we have considered salivary glands (SGs) as an alternative gene therapeutics target tissue...
- Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin functionPamela L Bradley
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Biol 257:249-62. 2003..These findings suggest that salivary tube dimensions may be an intrinsic property of salivary gland cells...
- The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoitesJoon Mo Myung
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
Mol Biochem Parasitol 133:53-9. 2004..Approximately 15-20% of oocyst sporozoites will successfully attach to and invade salivary glands, their target organ...
- Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glandsPeter Takac
Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovak Republic
J Exp Biol 209:343-52. 2006..The recombinant peptide prolonged the action potential and caused positive inotropism of isolated rat heart myocytes, and may be an ion channel modulator...
- Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren's syndrome in salivary glands of non-obese diabetic miceMargaret K Gatumu
Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Jonas Lies vei 65, N 5021 Bergen, Norway
Arthritis Res Ther 11:R24. 2009..The aim of this study was to determine the effects of LTbetaR pathway blockade on Sjögren syndrome (SS)-like salivary gland disease in non-obese diabetic (NOD) mice...
- Serological implications of germinal center-like structures in primary Sjögren's syndromeMalin V Jonsson
Department of Oral Sciences Oral Pathology and Forensic Odontology, Haukeland University Hospital, Bergen, Norway
J Rheumatol 34:2044-9. 2007..To determine serological implications of germinal center (GC)-like structures in primary Sjögren's syndrome (pSS)...
- Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glandsC Jhappan
Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
Genes Dev 6:345-55. 1992..The salivary glands, glands of the nasal mucosa and maxillary sinus, the extraorbital lacrimal glands, and the Harderian glands ..
- Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteinsAnil K Ghosh
Department of Molecular Microbiology and Immunology and Malaria Research Institute, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America
PLoS Pathog 5:e1000265. 2009..Together, the results suggest that saglin/TRAP interaction is crucial for salivary gland invasion by Plasmodium sporozoites...
- An insight into the sialotranscriptome of the non-blood feeding Toxorhynchites amboinensis mosquitoE Calvo
Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
Insect Biochem Mol Biol 38:499-507. 2008All adult mosquitoes take sugar meals, and most adult females also take blood meals to develop eggs. Salivary glands (SG) of males are thus much smaller and do not contain many of the antihemostatic and antiinflammatory compounds found ..
- The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glandsFabian E Saenz
Global Health and Infectious Diseases Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, United States of America
PLoS ONE 3:e2287. 2008Malaria transmission depends on infective stages in the mosquito salivary glands. Plasmodium sporozoites that mature in midgut oocysts must traverse the hemocoel and invade the mosquito salivary glands in a process thought to be mediated ..
- IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjögren's syndromeJ B Brayer
Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
Scand J Immunol 54:133-40. 2001..IL-4-/-. Despite manifesting the physiological aberrations and marked leukocytic infiltration of the salivary glands characteristic of autoimmune xerostomia in NOD mice, the NOD.IL-4-/- mice do not develop xerostomia...
- Two novel neuropeptides in innervation of the salivary glands of the black-legged tick, Ixodes scapularis: myoinhibitory peptide and SIFamideLadislav Simo
Department of Entomology, Kansas State University, Manhattan, Kansas 66506 4004, USA
J Comp Neurol 517:551-63. 2009..We identified two novel neuropeptides in the neuronal projections innervating the salivary glands of the black-legged tick, Ixodes scapularis (Say, 1821)...
- Identification of a complex peptidergic neuroendocrine network in the hard tick, Rhipicephalus appendiculatusLadislav Simo
Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 84506 Bratislava, Slovakia
Cell Tissue Res 335:639-55. 2009..project multiple processes through peripheral nerves to form elaborate axonal arborizations on the surface of salivary glands or to terminate in the lateral segmental organs (LSO)...
- Sunspot, a link between Wingless signaling and endoreplication in DrosophilaKenzui Taniue
Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
Development 137:1755-64. 2010..In addition, Ssp was found not to be involved in the signaling pathway mediated by Arm associated with dTCF. Our findings indicate that Arm controls development in part by regulating the function of Ssp...
- A prospective study of salivary gland function in patients undergoing radiotherapy for squamous cell carcinoma of the oropharynxPeter Moller
Department of Odontology and Stomatology, Centre Hospitalier Universitaire Vaudois, Switzerland
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:173-89. 2004..We sought to investigate the impact of head and neck cancer treatment on salivary function...
- The relationship between the levels of salivary cortisol and the presence of xerostomia in menopausal women. A preliminary studyBegoña Rivera Gómez
Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontologia, UCM, Madrid
Med Oral Patol Oral Cir Bucal 11:E407-12. 2006..Xerostomia is a particularly frequent occurrence among menopausal women, and is often associated with depression...
- Dental plaque pH and micro-organisms during hyposalivationL Eliasson
Department of Cariology, Faculty of Odontology, The Sahlgrenska Academy at Goteborg University, Box 450, SE 405 30 Goteborg, Sweden
J Dent Res 85:334-8. 2006..Stepwise regression tests suggested that the buccal minor-salivary-gland secretion rate in the test groups and counts of mutans streptococci in the controls were of significant importance for dental plaque pH...
- Dramatic and prolonged decrease of whole salivary secretion in nasopharyngeal carcinoma patients treated with radiotherapyYee Min Jen
Department of Radiation Oncology, Tri Service General Hospital, Taipei, Taiwan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:322-7. 2006..during, and after radiotherapy, especially during the first week of irradiation; (2) the recovery capability of salivary glands up to 2 years postirradiation; and (3) the possible prognostic factors affecting salivary gland functions.
- Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?Anke Petra Jellema
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
Radiother Oncol 77:164-71. 2005..To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva...
- Clinical and biochemical evaluation of the saliva of patients with xerostomia induced by radiotherapyCássio de Barros Pontes
Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo
Braz Oral Res 18:69-74. 2004..Clinically, patients presenting xerostomia induced by radiotherapy presented an increase in oral tissue injury...
- PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROMESAMUEL HOPKINS; Fiscal Year: 2005..Over time, progressive infiltration of lacrimal and salivary glands by mononuclear cells leads to diminished secretions, with resultant xerostomia (dry mouth) and xeropthalmia (..
- Mechanisms of FGFR2 Signaling in Salivary Gland Branching MorphogenesisVeraragavan P Eswarakumar; Fiscal Year: 2010..However, the lack of salivary glands in Fgf10 or Fgfr2b knockout mice precludes further investigation of branching morphogenesis in these mouse ..
- HCO3- Conductive function of CFTR: Implications to Oral Health & Cystic FibrosisMADIREDDI REDDY; Fiscal Year: 2009Bicarbonate is a vital component of secretions from exocrine glands such as salivary glands, pancreas, duodenum, reproductive organs, sweat glands and the airways...
- HCO3- Conductive function of CFTR: Implications to Oral Health & Cystic FibrosisMADIREDDI REDDY; Fiscal Year: 2010Bicarbonate is a vital component of secretions from exocrine glands such as salivary glands, pancreas, duodenum, reproductive organs, sweat glands and the airways...
- Exploring How HTLV-1 Tax Induces T Cell LeukemiaWarner Greene; Fiscal Year: 2006..of poorly understood autoimmune or inflammatory diseases that affect different end organs including the eye, salivary glands, joints, and muscle...
- Interactions Between Anaplasma Phagocytophilum and Ixodes ScapularisErol Fikrig; Fiscal Year: 2010..that resides in 2 different locations during its life cycle -- mammalian neutrophils and Ixodes scapularis salivary glands. This project investigates whether tick genes that are up- or down-regulated in the presence of A...
- IL-4 Signaling Pathway Regulation of Sjogren's SyndromeAMMON PECK; Fiscal Year: 2004..by exocrine dysfunction resulting from the action of1 a chronic autoimmune attack against the lacrimal and salivary glands. It is one of the leading causes of salivary gland inflammation and dysfunction, leading to severe dryness of ..
- ANTIVIRAL ACTIVITY OF THE IMMUNOSUPPRESSANT LEFLUNOMIDEW Waldman; Fiscal Year: 2004..b>Salivary glands, spleen, and lungs will be examined histologically for viral pathology, and assayed for viral load by plaque ..
- REGULATION OF CYSTATIN S GENE EXPRESSIONPHYLLIS SHAW; Fiscal Year: 2002Mammalian salivary glands produce secretions that initiate digestion and bathe and protect the oral cavity...
- The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide ReceptorsGARY WEISMAN; Fiscal Year: 2009..To develop techniques for the successful regeneration of salivary glands in vivo, it is first necessary to understand signaling pathways that regulate gland development, which ..
- The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide ReceptorsGARY ANDREW WEISMAN; Fiscal Year: 2010..To develop techniques for the successful regeneration of salivary glands in vivo, it is first necessary to understand signaling pathways that regulate gland development, which ..
- SODIUM ENTRY INTO AMILORIDE-SENSITIVE EPITHELIACatherine M Fuller; Fiscal Year: 2010..Epithelial sodium channels (ENaC) have been found in other sodium transportinmg epithelia, e.g., salivary glands, colon, bronchial and tracheal epithelia, as well as in many non-epithelial cells, like lymphocytes, neurons ..
- MAXADILAN, A CUTANEOUS VASODILATOR FROM SAND FLIESEthan Lerner; Fiscal Year: 2002Maxadilan is the most potent vasodilator known. It is a novel peptide recently isolated from salivary glands of the sand fly Lutzomyia longipalpis, a vector of the protozoan disease leishmaniasis...
- Oral Immunobiology of MCMV-infected Mouse Salivary GlandsSTEVEN LONDON; Fiscal Year: 2006..In addition, the salivary glands are a major component in the mucosal immune system of the oral cavity that confers antigen-specific immunity ..
- Rescue of radiation-induced salivary gland dysfunction by AktKIRSTEN LIMESAND; Fiscal Year: 2007b>Salivary glands are the site of aberrant apoptosis following head and neck irradiation resulting in severe glandular dysfunction...
- Proteomics of mosquito immune response to malariaKENNETH VERNICK; Fiscal Year: 2002..Sporozoites must migrate within hemolymph and invade the salivary glands in order for transmission to occur...
- Novel Mechanisms of Chronic Inflammation in Sjogren's SyndromeGARY WEISMAN; Fiscal Year: 2007..syndrome (SS) is an autoimmune disorder characterized by inflammation and destruction of lacrimal and salivary glands leading to decreased fluid secretion (xerostomia) often associated with lymphocytic infiltration of the ..
- SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINSDouglas Darling; Fiscal Year: 2007..of this research is to determine the mechanisms for sorting and storage of regulated secretory proteins in salivary glands. The answer to this question is important for our understanding of the regulation of protein secretion from ..
- Modeling Dynamics of Salivary Gland Branching MorphogenesisBulent Yener; Fiscal Year: 2010..Existing strategies for engineering salivary glands have been unable to create a complex branched structure or successfully produce saliva-secreting acinar cells,..