palate

Summary

Summary: The structure that forms the roof of the mouth. It consists of the anterior hard palate (PALATE, HARD) and the posterior soft palate (PALATE, SOFT).

Top Publications

  1. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
  2. ncbi Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
    Zunyi Zhang
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 129:4135-46. 2002
  3. ncbi The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice
    Sylvia R Alappat
    Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 277:102-13. 2005
  4. pmc Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate
    Ritva Rice
    Departments of Craniofacial Development and Orthodontics, King s College, London, United Kingdom
    J Clin Invest 113:1692-700. 2004
  5. ncbi Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
    Yoshihiro Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 130:5269-80. 2003
  6. pmc Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development
    Jeffrey O Bush
    Department of Cell and Tissue Biology and Program in Craniofacial and Mesenchymal Biology, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 139:231-43. 2012
  7. ncbi Death is the major fate of medial edge epithelial cells and the cause of basal lamina degradation during palatogenesis
    Rodrigo Cuervo
    Departament of Developmental Genetics and Molecular Physiology, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62210, Mexico
    Development 131:15-24. 2004
  8. pmc TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    J Cell Sci 120:1646-53. 2007
  9. ncbi Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation
    Giovanni Levi
    Evolution des Regulations Endocriniennes, CNRS UMR5166, Museum national d histoire naturelle, Paris, France
    Mech Dev 123:3-16. 2006
  10. pmc Cleft palate: players, pathways, and pursuits
    Jeffrey C Murray
    Department of Pediatrics and Craniofacial Anomalies Research Center, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 113:1676-8. 2004

Detail Information

Publications274 found, 100 shown here

  1. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
    Mice lacking TGF-beta 3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and ..
  2. ncbi Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
    Zunyi Zhang
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 129:4135-46. 2002
    Cleft palate, the most frequent congenital craniofacial birth defects in humans, arises from genetic or environmental perturbations in the multi-step process of palate development...
  3. ncbi The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice
    Sylvia R Alappat
    Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 277:102-13. 2005
    ..In this study, we report the presence of a wide-open cleft secondary palate in Fgf10 homozygous null mutant mice. Fgf10 transcripts were detected in the palatal mesenchyme from E11.5 to E13...
  4. pmc Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate
    Ritva Rice
    Departments of Craniofacial Development and Orthodontics, King s College, London, United Kingdom
    J Clin Invest 113:1692-700. 2004
    Classical research has suggested that early palate formation develops via epithelial-mesenchymal interactions, and in this study we reveal which signals control this process...
  5. ncbi Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
    Yoshihiro Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 130:5269-80. 2003
    Cleft palate and skull malformations represent some of the most frequent congenital birth defects in the human population...
  6. pmc Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development
    Jeffrey O Bush
    Department of Cell and Tissue Biology and Program in Craniofacial and Mesenchymal Biology, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 139:231-43. 2012
    ..The complexity of control of palatogenesis is reflected by the common occurrence of cleft palate in humans...
  7. ncbi Death is the major fate of medial edge epithelial cells and the cause of basal lamina degradation during palatogenesis
    Rodrigo Cuervo
    Departament of Developmental Genetics and Molecular Physiology, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62210, Mexico
    Development 131:15-24. 2004
    During mammalian development, a pair of shelves fuses to form the secondary palate, a process that requires the adhesion of the medial edge epithelial tissue (MEE) of each shelf and the degeneration of the resulting medial epithelial seam ..
  8. pmc TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    J Cell Sci 120:1646-53. 2007
    Dissociation of medial-edge epithelium (MEE) during palate development is essential for mediating correct craniofacial morphogenesis...
  9. ncbi Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation
    Giovanni Levi
    Evolution des Regulations Endocriniennes, CNRS UMR5166, Museum national d histoire naturelle, Paris, France
    Mech Dev 123:3-16. 2006
    ..and middle ear), synergistically (deposition of bone tissue) or converging on the same morphogenetic process (palate growth and closure)...
  10. pmc Cleft palate: players, pathways, and pursuits
    Jeffrey C Murray
    Department of Pediatrics and Craniofacial Anomalies Research Center, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 113:1676-8. 2004
    Cleft lip and palate is a common human birth defect, and its causes are being dissected through studies of human populations and through the use of animal models...
  11. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct from isolated cleft secondary palate (CP)...
  12. ncbi Multiple functions of Snail family genes during palate development in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 134:1789-97. 2007
    b>Palate development requires precise regulation of gene expression changes, morphogenetic movements and alterations in cell physiology. Defects in any of these processes can result in cleft palate, a common human birth defect...
  13. ncbi Reduced tongue pressure against the hard palate on the paralyzed side during swallowing predicts Dysphagia in patients with acute stroke
    Nobuko Hirota
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
    Stroke 41:2982-4. 2010
    ..The present study investigated the relationship between tongue motor deficits and dysphagia in patients with acute stroke...
  14. ncbi Hedgehog signalling in development of the secondary palate
    Martyn T Cobourne
    Department of Craniofacial Development, King s College London Dental Institute, London, UK
    Front Oral Biol 16:52-9. 2012
    ..In the developing palate, Shh is strongly expressed in the epithelium on the oral surface, in a series of stripes corresponding to the ..
  15. pmc Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes
    Huimin Yu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA
    Development 139:4383-94. 2012
    ..septal defects (VSDs) with ~15% penetrance; Fz2(+/-);Fz7(-/-) mice exhibit VSDs with ~50% penetrance and cleft palate with less than 10% penetrance; and Fz2(-/-);Fz7(-/-) mice exhibit convergent extension defects and mid-gestational ..
  16. pmc Epithelial-specific requirement of FGFR2 signaling during tooth and palate development
    Ryoichi Hosokawa
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Exp Zool B Mol Dev Evol 312:343-50. 2009
    ..K14-Cre;Fgfr2(fl/fl) mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of ..
  17. pmc Histomorphological study of palatal shelf elevation during murine secondary palate formation
    Kai Yu
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    Dev Dyn 240:1737-44. 2011
    During mammalian secondary palate development, the palatal shelves undergo dramatic morphological changes to elevate from a vertical to a horizontal plane in the oral-nasal cavity. We found that E14...
  18. ncbi EphB2 and EphB3 forward signalling are required for palate development
    Michael Risley
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
    Mech Dev 126:230-9. 2009
    ..Previous work had shown that the loss of ephrinB1 protein alone or compound loss of EphB2 and EphB3 leads to cleft palate. Because of the bidirectional signalling capability of these molecules, it was not clear whether forward or ..
  19. ncbi Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse
    Susann Zirzow
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 336:145-55. 2009
    Formation of the mammalian secondary palate is a highly regulated and complex process. Impairment of the underlying cellular and molecular programs often results in cleft palate, a common birth defect in mammals...
  20. pmc The mechanism of TGF-β signaling during palate development
    J Iwata
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Oral Dis 17:733-44. 2011
    Cleft palate, a malformation of the secondary palate development, is one of the most common human congenital birth defects...
  21. ncbi Efficiency of a skeletonized distal jet appliance supported by miniscrew anchorage for noncompliance maxillary molar distalization
    Gero S M Kinzinger
    Department of Orthodontics, University of Saarland, Homburg Saar, Germany
    Am J Orthod Dentofacial Orthop 136:578-86. 2009
    ..The partial coverage of the palate, in particular, often results in compromised oral hygiene...
  22. ncbi Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure
    P J Miettinen
    Department of Growth and Development, University of California, San Francisco 94143 0452, USA
    Nat Genet 22:69-73. 1999
    Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,000 live births among ..
  23. ncbi A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Genet 36:1111-6. 2004
    ..perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos...
  24. ncbi Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung
    W M Weston
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:13698-703. 1999
    ..In situ hybridization analysis shows discrete regions of expression associated with the palate, nasal septum, and nasal conchae...
  25. ncbi Biological mechanisms in palatogenesis and cleft palate
    L Meng
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Dent Res 88:22-33. 2009
    Clefts of the palate are common birth defects requiring extensive treatment. They appear to be caused by multiple genetic and environmental factors during palatogenesis...
  26. ncbi Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, Aab Institute of Biomedical Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 131:3207-16. 2004
    Development of the mammalian secondary palate involves multiple steps of highly regulated morphogenetic processes that are frequently disturbed during human development, resulting in the common birth defect of cleft palate...
  27. pmc Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development
    Liam M Casey
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1830-44. 2006
    ..developing tongue and subsequently elevate and fuse with each other above the tongue to form the intact secondary palate. Pathological palate-mandible or palate-tongue fusions have been reported in humans and other mammals, but the ..
  28. ncbi Palate re-repair revisited
    Brian C Sommerlad
    St Andrew s Centre for Plastic Surgery, Broomfield Hospital, Essex, England, UK
    Cleft Palate Craniofac J 39:295-307. 2002
    To analyze the results of a consecutive series of palate re-repairs performed using the operating microscope and identify predictive factors for outcome.
  29. pmc Regional regulation of palatal growth and patterning along the anterior-posterior axis in mice
    Sylvia A Hilliard
    Division of Developmental Biology, Department of Cell and Molecular Biology, and Center for Bioenvironmental Research, Tulane University, New Orleans 70118, USA
    J Anat 207:655-67. 2005
    Cleft palate is a congenital disorder arising from a failure in the multistep process of palate development. In its mildest form the cleft affects only the posterior soft palate...
  30. pmc Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate
    Alison K Snyder-Warwick
    Division of Plastic Surgery, Departments of Developmental Biology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:2515-20. 2010
    Cleft palate is a common birth defect in humans and is a common phenotype associated with syndromic mutations in fibroblast growth factor receptor 2 (Fgfr2)...
  31. pmc Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 136:1387-96. 2009
    The mammalian secondary palate arises by outgrowth from the oral side of the paired maxillary processes flanking the primitive oral cavity...
  32. ncbi Distinct requirements for wnt9a and irf6 in extension and integration mechanisms during zebrafish palate morphogenesis
    Max Dougherty
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Development 140:76-81. 2013
    Development of the palate in vertebrates involves cranial neural crest migration, convergence of facial prominences and extension of the cartilaginous framework...
  33. ncbi Palatal shelf movement during palatogenesis: a fate map of the fetal mouse palate cultured in vitro
    Ming Jen Chou
    Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, 606 8501 Kyoto, Japan
    Anat Embryol (Berl) 208:19-25. 2004
    ..It seems that in the fetal mouse palate, the midpalate closes mainly by means of rotation and medial elongation of the shelf, whereas the anterior and ..
  34. pmc Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate
    Andrew D Economou
    Department of Craniofacial Development, King s College London, UK
    Nat Genet 44:348-51. 2012
    ..evidence of an activator-inhibitor system in the generation of the regularly spaced transverse ridges of the palate. We show that new ridges, called rugae, that are marked by stripes of expression of Shh (encoding Sonic hedgehog), ..
  35. pmc Mesenchymal cell remodeling during mouse secondary palate reorientation
    Jiu Zhen Jin
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville, Louisville, Kentucky
    Dev Dyn 239:2110-7. 2010
    The formation of mammalian secondary palate requires a series of developmental events such as growth, elevation, and fusion...
  36. ncbi Altered mandibular development precedes the time of palate closure in mice homozygous for disproportionate micromelia: an oral clefting model supporting the Pierre-Robin sequence
    James E Ricks
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Teratology 65:116-20. 2002
    ..interaction of the expanding tongue and elongating Meckel's cartilage correlates with the appearance of cleft palate. Mice homozygous for the semi-dominant Col2a1 mutation Disproportionate micromelia (Dmm), presenting at birth with ..
  37. pmc Roles of BMP signaling pathway in lip and palate development
    Carolina Parada
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Front Oral Biol 16:60-70. 2012
    Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are severe disruptions affecting orofacial structures...
  38. ncbi Nasopalatine duct cyst: report of 22 cases and review of the literature
    Jaume Escoda Francoli
    University of Barcelona Dental School, Spain
    Med Oral Patol Oral Cir Bucal 13:E438-43. 2008
    ..The present study describes the clinicopathological characteristics of 22 NPDCs and discusses their etiology, incidence, treatment and prognosis, with a review of the literature on the subject...
  39. pmc Applied anatomic site study of palatal anchorage implants using cone beam computed tomography
    Ren fa Lai
    Clinic of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China
    Int J Oral Sci 2:98-104. 2010
    ..The purpose of this study was to conduct quantitative research on bone height and bone mineral density of palatal implant sites for implantation, and to provide reference sites for safe and stable palatal implants...
  40. pmc Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate
    Ian C Welsh
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 336:53-67. 2009
    ..We have identified a unique region of the secondary palate associated with the periodic formation of rugae during the rostral outgrowth of the face...
  41. ncbi Face, palate, and craniofacial morphology in patients with a solitary median maxillary central incisor
    I Kjaer
    Department of Orthodontics, University of Copenhagen, Denmark
    Eur J Orthod 23:63-73. 2001
    ..It is therefore suggested that the SMMCI condition in future studies is classified according to clinical symptoms and craniofacial morphology...
  42. ncbi Mandibular growth retardation as a cause of cleft palate in mice homozygous for the chondrodysplasia gene
    R E Seegmiller
    J Embryol Exp Morphol 38:227-38. 1977
    ..in C57BL mice homozygous for the chondrodysplasia gene leads to deformity of limbs, ribs, trachea, mandible and palate. Since formation of the secondary palate depends upon coordinated development of several craniofacial structures, ..
  43. pmc The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice
    Wenjin Liu
    Department of Biomedical Genetics and Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 135:3959-68. 2008
    The mammalian secondary palate exhibits morphological, pathological and molecular heterogeneity along the anteroposterior axis...
  44. pmc Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes
    Erwin Pauws
    UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH London, UK
    Hum Mol Genet 18:4171-9. 2009
    Craniofacial defects involving the lip and/or palate are among the most common human birth defects. X-linked cleft palate and ankyloglossia results from loss-of-function mutations in the gene encoding the T-box transcription factor TBX22...
  45. pmc Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development
    Sophie Pantalacci
    Molecular Zoology, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
    BMC Dev Biol 8:116. 2008
    The development of the secondary palate has been a main topic in craniofacial research, as its failure results in cleft palate, one of the most common birth defects in human...
  46. ncbi Alteration in the expression of bone morphogenetic protein-2,3,4,5 mRNA during pathogenesis of cleft palate in BALB/c mice
    H Lu
    Department of Oral Pathology, Stomatological College, Xi an, People s Republic of China
    Arch Oral Biol 45:133-40. 2000
    To identify the function of these bone morphogenetic proteins (BMP) during pathogenesis of cleft palate, an experimental model was established in BALB/c mice. Cleft palate was induced by exposure to retinoic acid on embryonic day (E)12...
  47. ncbi Vanilloid receptor expression in the rat tongue and palate
    M A Kido
    Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    J Dent Res 82:393-7. 2003
    ..Immunohistochemistry revealed that the taste papillae in the tongue and palate are richly innervated by VR1-immunoreactive nerve fibers...
  48. ncbi Spectrum of indications for palatal implants in treatment concepts involving immediate and conventional loading
    Britta A Jung
    Department of Orthodontics, University Medical Center of Johannes Gutenberg University, Mainz, Germany
    J Orofac Orthop 71:273-80. 2010
    ..To analyze the spectrum of indications for second-generation palatal implants in relation to two different loading concepts in a prospective, multicenter, randomized controlled trial (RCT)...
  49. ncbi Palatal fusion - where do the midline cells go? A review on cleft palate, a major human birth defect
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Mail Stop 35, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Acta Histochem 109:1-14. 2007
    Formation of the palate, the organ that separates the oral cavity from the nasal cavity, is a developmental process characteristic to embryos of higher vertebrates. Failure in this process results in palatal cleft...
  50. ncbi Quantitative investigation of palatal bone depth and cortical bone thickness for mini-implant placement in adults
    Sebastian Baumgaertel
    Department of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Orthod Dentofacial Orthop 136:104-8. 2009
    ..The purpose of this study was to investigate both variables in the palate quantitatively to aid clinicians in planning successful mini-implant placements.
  51. pmc Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice
    Jun Han
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 136:4225-33. 2009
    Cleft palate represents one of the most common congenital birth defects in human...
  52. ncbi Hoxa2 plays a direct role in murine palate development
    Tara M Smith
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Dev Dyn 238:2364-73. 2009
    The cleft palate exhibited by Hoxa2 null murine embryos has been described as being secondary to abnormalities of tongue musculature, and Hoxa2 was presumed to not play a direct role in palate development...
  53. ncbi Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair
    Nina Dathan
    Centro di Studi di Biocristallografia del CNR, Via Mezzocannone, Naples, Italy
    Dev Dyn 224:450-6. 2002
    ..Titf2 null mice exhibit cleft palate and either a sublingual or completely absent thyroid gland...
  54. pmc Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
    Huimin Yu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA
    Development 137:3707-17. 2010
    ..is a recurrent theme in mammalian embryology, and this process plays an integral role in the development of the palate, ventricular septum, neural tube, urethra, diaphragm and eye...
  55. ncbi Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
    Jong Min Lee
    Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University, Seoul, Republic of Korea
    Dev Biol 314:341-50. 2008
    Various cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development...
  56. pmc Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation
    Hiroyuki Enomoto
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Development 137:4029-38. 2010
    ..overlap of Adamts9 with Adamts20 was identified using Adamts9(+/-);bt/bt mice, which have a fully penetrant cleft palate. Palate closure was delayed, although eventually completed, in both Adamts9(+/-);bt/+ and bt/bt mice, ..
  57. ncbi Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    V Kaartinen
    Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA
    Nat Genet 11:415-21. 1995
    ..Unlike other null mutants with cleft palate, TGF-beta 3-/- mice lack other concomitant craniofacial abnormalities...
  58. ncbi Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)
    A Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, Goldensen Bldg, Room 342, Boston, MA 02115, USA
    Arch Oral Biol 49:675-89. 2004
    Formation of the medial edge epithelial (MEE) seam by fusing the palatal shelves is a crucial step of palate development. The opposing shelves adhere to each other at first by adherens junctions, then by desmosomes in the MEE...
  59. pmc Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation
    D Orioli
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 15:6035-49. 1996
    ..either Sek4 or Nuk are viable, most sek4/nuk1 double mutants die immediately after birth primarily due to a cleft palate. These results demonstrate essential and cooperative functions for Sek4 and Nuk in establishing axon pathways in ..
  60. ncbi TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion
    Consuelo Tudela
    Departamento de Ciencias Morfológicas I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    Int J Dev Biol 46:333-6. 2002
    Transforming growth factor-beta3 (TGF-beta3) plays a critical role during palate development, since mutations of the TGF-beta3 gene give rise to cleft palate in both humans and mice...
  61. pmc The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 356:40-50. 2011
    Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction...
  62. pmc TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
    Ali Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, B 1, Room 342, Boston, MA 02115 6092, USA
    J Cell Biol 163:1291-301. 2003
    ..We show with antisense beta-catenin oligonucleotides that up-regulated LEF1 is not activated by beta-catenin in palate EMT...
  63. pmc Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants
    Liang Tung Yang
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Dev Biol 312:384-95. 2007
    ..is strongly expressed in the prefusion palatal epithelium, and mice lacking Tgfb3 display a cleft of the secondary palate. To test whether the effect of TGF-beta3 in palatogenesis is isoform-specific in vivo, we generated a knockin ..
  64. ncbi Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion
    C L Brunet
    Division of Cells, Immunology and Development, School of Biological Sciences, University of Manchester, United Kingdom
    Int J Dev Biol 39:345-55. 1995
    ..Prevention of mature TGF-beta 3 activity during a specific time window of development in palate organ cultures, either by antisense oligodeoxynucleotides or neutralizing antibody, resulted in failure of palate ..
  65. pmc Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene
    G Caruana
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Mol Cell Biol 21:1475-83. 2001
    ..exhibit growth retardation in utero, have hypoplasia of the premaxilla and mandible, have a cleft secondary palate, and die perinatally...
  66. ncbi Pathogenesis of cleft palate in TGF-beta3 knockout mice
    Y Taya
    Division of Cells, Immunology and Development, School of Biological Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Development 126:3869-79. 1999
    We previously reported that mutation of the transforming growth factor-beta3 (TGF-beta3) gene caused cleft palate in homozygous null (-/-) mice...
  67. ncbi Three-dimensional morphology of the palate in subjects with isolated cleft palate at the stage of permanent dentition
    Zbynek Smahel
    Faculty of Natural Sciences and Chairman of the Committee for Postgraduate Studies in Anthropology at Charles University, Prague, Czech Republic
    Cleft Palate Craniofac J 40:577-84. 2003
    Three-dimensional analysis of palate size and shape in patients with isolated cleft palate at the stage of permanent dentition.
  68. ncbi A nasopalatine cyst in an 8-year-old child
    M T Velasquez-Smith
    Department of Paediatric Dentistry, Eastman Dental Hospital, London, UK
    Int J Paediatr Dent 9:123-7. 1999
    ..The most commonly reported clinical symptom is swelling in the anterior part of the palate. The treatment of choice is enucleation...
  69. ncbi Intrinsic regulation of differentiation markers in human epidermis, hard palate and buccal mucosa
    S Gibbs
    Department of Dermatology, Leiden University Medical Centre, Sylvius Laboratory, The Netherlands
    Arch Oral Biol 45:149-58. 2000
    Different epithelia show extensive variation in differentiation. Epidermis and epithelium from the hard palate are both typical examples of orthokeratinized epithelia whereas buccal mucosa is an example of a non-keratinized epithelium...
  70. pmc Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis
    Jing Zhou
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 140:4709-18. 2013
    Cleft palate is one of the most common birth defects in humans...
  71. ncbi Use of gutta percha cores in CT scan imaging for patent nasopalatine duct
    S Catros
    Département d odontologie et de santé buccale, Hopital Pellegrin, Place Amelie Raba Leon, Bordeaux, France
    Int J Oral Maxillofac Surg 37:1065-6. 2008
    ..Gutta percha cores were inserted in nasopalatine ducts to improve their visualization on CT scans. This simple method enhances the diagnostic quality of these images so that surgery can be performed more precisely...
  72. ncbi Quantitative description of the morphology of the human palate by a mathematical equation
    V F Ferrario
    Functional Anatomy Research Center, Istituto di Anatomia Umana Normale, Facolta di Medicina e Chirurgia, Universita degli Studi, Milano, Italy
    Cleft Palate Craniofac J 35:396-401. 1998
    ..To derive a three-dimensional mathematical description of normal human hard tissue palatal size and shape...
  73. pmc Mice with an anterior cleft of the palate survive neonatal lethality
    Shuping Gu
    Section of Oral Biology, The Ohio State University College of Dentistry, Columbus, Ohio 43210, USA
    Dev Dyn 237:1509-16. 2008
    Many genes are known to function in a region-specific manner in the developing secondary palate. We have previously shown that Shox2-deficient embryos die at mid-gestation stage and develop an anterior clefting phenotype...
  74. pmc Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo
    Nikolaos Gkantidis
    Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Bern, Bern, Switzerland
    PLoS ONE 7:e47762. 2012
    Morphogenesis of the secondary palate in mammalian embryos involves two major events: first, reorientation of the two vertically oriented palatal shelves into a horizontal position above the tongue, and second, fusion of the two shelves ..
  75. ncbi Cell cycle proteins in normal and chemically induced abnormal secondary palate development: a review
    Vamsidhara C Dhulipala
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Exp Toxicol 25:675-82. 2006
    ..Craniofacial tissues including the secondary palate are vulnerable to disruption of cell cycle progression and proliferation by many chemicals including mycotoxin, ..
  76. ncbi [Differential expression of Bmp2, Bmp4 and Bmp3 in embryonic development of mouse anterior and posterior palate]
    Xu Guang Nie
    Sector of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Norway
    Chin Med J (Engl) 118:1710-6. 2005
    The palate is differently regulated and developed along the anterior-posterior axis. The Bmp signal pathway plays a crucial role in palatogenesis...
  77. pmc From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome
    Neus Martínez-Abadías
    Department of Anthropology, Pennsylvania State University, 409 Carpenter Building, University Park, PA 16802, USA
    Dis Model Mech 6:768-79. 2013
    ..bases underlying differential Apert syndrome phenotypes are still poorly understood and it is unclear why cleft palate is more frequent in patients carrying the S252W mutation...
  78. ncbi Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis
    George Kamel
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States
    Dev Biol 381:423-33. 2013
    ..This study underscores the important role of wnt-frizzled signaling in convergence and extension in palate and craniofacial morphogenesis, distinct regulation of upper vs...
  79. ncbi Occurrence and temporal variation in matrix metalloproteinases and their inhibitors during murine secondary palatal morphogenesis
    J Morris-Wiman
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, USA
    J Craniofac Genet Dev Biol 19:201-12. 1999
    Extracellular matrix (ECM) molecules are known to play a pivotal role in morphogenesis of the secondary palate, and changes in their composition and distribution, not attributable to changes in synthesis, are known to occur during ..
  80. pmc Palate morphogenesis: current understanding and future directions
    Robert M Greene
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, ULSD, Louisville, Kentucky 40292, USA
    Birth Defects Res C Embryo Today 90:133-54. 2010
    ..The secondary palate has provided an excellent paradigm that has enabled examination of a wide variety of developmental processes...
  81. pmc Expression of Wnts in the developing murine secondary palate
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Kentucky 40292, USA
    Int J Dev Biol 53:1105-12. 2009
    Morphogenesis of the mammalian secondary palate requires coordination of cell migration, proliferation, differentiation, apoptosis and synthesis of extracellular matrix molecules by numerous signal transduction pathways...
  82. pmc PI-3 kinase activity is required for epithelial-mesenchymal transformation during palate fusion
    Pei Kang
    Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 225:316-21. 2002
    ..transformation (EMT) is the primary mechanism for the disappearance of medial edge epithelia (MEE) during palate fusion...
  83. ncbi Retinoic acid inhibits osteogenic differentiation of mouse embryonic palate mesenchymal cells
    Mu Chen
    Guanghua School of Stomatology and Institute of Stomarological Research, Sun Yat Sen University, Lingyuan Xilu 56, Guangzhou, China
    Birth Defects Res A Clin Mol Teratol 88:965-70. 2010
    All-trans-retinoic acid (ATRA), a known teratogenic factor affecting the development of cleft palate, has been shown to adversely affect craniofacial development...
  84. ncbi Perturbation of Fgf10 signal pathway in mouse embryonic palate by dexamethasone and vitamin B12 in vivo
    Wei He
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
    J Pediatr Surg 45:2030-5. 2010
    ..The objective of this study was to assess whether dexamethasone and vitamin B(12) affected the Fgf10 signal pathway of mouse embryonic palate.
  85. ncbi Variability in palatal shape and size in patients with bilateral complete cleft lip and palate assessed using dense surface model construction and 3D geometric morphometrics
    Sárka Bejdová
    Department of Anthropology and Human Genetics, Faculty of Science, Charles University in Prague, Vinicna 7, Prague 2, Czech Republic
    J Craniomaxillofac Surg 40:201-8. 2012
    Bilateral complete cleft lip and palate (BCLP) is the most severe of the common orofacial clefts and is associated with the greatest deformity during development...
  86. ncbi Evaluation of the palate dimensions of patients with perennial allergic rhinitis
    - de Freitas FCN
    Department of Paediatric Dentistry and Orthodontics, Federal University of Rio de Janeiro, Brazil
    Int J Paediatr Dent 11:365-71. 2001
    The purpose of this study was to compare the transverse and vertical palate dimensions of two groups of children, one diagnosed as having perennial allergic rhinitis (PAR) and the other without any respiratory pathology.
  87. pmc Mechanisms of transforming growth factor β induced cell cycle arrest in palate development
    Tatiana Iordanskaia
    Department of Oral Biology, College of Dentistry, The University of Nebraska Medical Center, Lincoln, Nebraska 68512, USA
    J Cell Physiol 226:1415-24. 2011
    Immaculate and complete palatal seam disintegration, which takes place at the last phase of palate development, is essential for normal palate development...
  88. ncbi A new approach to classify cleft lip and palate
    M R Ortiz-Posadas
    Universidad Autonoma Metropolitana Iztapalapa, Ingenieria Electrica, Av Michoacán y La Purisima S N Col Vicentina C P 09340, D F Mexico
    Cleft Palate Craniofac J 38:545-50. 2001
    To propose a new method, which allows for a complete description of primary and secondary cleft palates, incorporating elements that are related to the palate, lip, and nose that will also reflect the complexity of this problem.
  89. ncbi MiR-200b is involved in Tgf-β signaling to regulate mammalian palate development
    Jeong Oh Shin
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei University, 50 Yonsei ro, Seodaemoon Gu, Seoul 120 752, Korea
    Histochem Cell Biol 137:67-78. 2012
    ..key mediators of the transforming growth factor beta (Tgf-β) pathway, play a crucial role in the regulation of palate development...
  90. ncbi Diphenylhydantoin plays a role in gene expression related to cytoskeleton and protein adhesion in human normal palate fibroblasts
    Furio Pezzetti
    Histology, Embryology and Applied Biology Department, University of Bologna, Bologna, Italy
    Pathology 41:261-8. 2009
    Morphogenetic processes during palate development are related to extracellular matrix composition. The cell-extracellular matrix relation plays a role in cell activity and in gene expression...
  91. doi Clinical images: perforation of the nasal septum and palate due to Wegener's granulomatosis
    Timucin Kasifoglu
    Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey
    Arthritis Rheum 58:2564. 2008
  92. ncbi Inhibition of human embryonic palatal mesenchymal cell cycle by secalonic acid D: a probable mechanism of its cleft palate induction
    V C Dhulipala
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Orthod Craniofac Res 7:227-36. 2004
    To assess the mechanism(s) of cleft palate induction by secalonic acid D (SAD) in human embryonic palatal mesenchymal (HEPM) cells and compare them with those evaluated in the murine embryonic palate.
  93. ncbi Occlusal relationship in patients with bilateral cleft lip and palate during the mixed dentition stage: does neonatal maxillary arch configuration predetermine outcome?
    Chad A Perlyn
    Cleft Palate and Craniofacial Deformities Institute, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cleft Palate Craniofac J 39:317-21. 2002
    To determine whether there is any correlation between initial maxillary arch dysmorphology patterns in complete bilateral cleft lip/palate (BCLP) and the subsequent occlusal relationship in early mixed dentition.
  94. ncbi Anatomical study of the greater palatine artery and related structures of the palatal vault: considerations for palate as the subepithelial connective tissue graft donor site
    Sebastian Krystian Klosek
    Department of Periodontology and Oral Mucosal Diseases, Medical University of Lodz, 92 216, Lodz, Poland
    Surg Radiol Anat 31:245-50. 2009
    b>Palate is considered as a tissue graft donor site for dental surgical procedures...
  95. pmc Gsk3β is required in the epithelium for palatal elevation in mice
    Fenglei He
    Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA
    Dev Dyn 239:3235-46. 2010
    ..Inactivation of Gsk3β in mice causes a cleft palate formation, suggesting an involvement of Wnt/β-catenin signaling during palatogenesis...
  96. ncbi [Necrotizing sialometaplasia of the palate. Literature report of 3 new cases]
    A Schmidt Westhausen
    ,
    Dtsch Z Mund Kiefer Gesichtschir 15:30-4. 1991
    In this study 3 cases diagnosed as necrotizing sialometaplasia (NS) of the palate are described and discussed together with 106 other cases cited in the literature...
  97. pmc ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
    R Shalom-Feuerstein
    INSERM U898, University of Nice, 28 Avenue Valombrose, Nice, France
    Cell Death Differ 18:887-96. 2011
    ..These data highlight the earliest recognized action of ΔNp63 in the induction epidermal morphogenesis at E11.5. In the absence of p63, a mesodermal program is activated while epidermal morphogenesis does not initiate...
  98. ncbi Dental CT and orthodontic implants: imaging technique and assessment of available bone volume in the hard palate
    Andre Gahleitner
    Department of Radiology Osteology and MR, Medical School, University of Vienna, Wahringer Gurtel 18, A 1090, Austria
    Eur J Radiol 51:257-62. 2004
    ..The aim of this study was to determine whether dental CT could serve as a tool to locate the optimal size and position for orthodontic implant placement...
  99. ncbi Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate
    Luca Scapoli
    Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, University of Bologna, Via Belmeloro, 8, 40126 Bologna, Italy
    Hum Mutat 31:794-800. 2010
    Nonsyndromic cleft lip with or without cleft palate (CL/P) affects approximately 1 in 1,000 births...
  100. ncbi Mechanism of secalonic acid D-induced inhibition of transcription factor binding to cyclic AMP response element in the developing murine palate
    Umesh M Hanumegowda
    Department of Veterinary Biomedical Sciences, University of Missouri, W148 Vet Med Bldg, 1600 E Rollins, Columbia, Missouri 65211, USA
    Toxicol Sci 70:55-62. 2002
    ..Secalonic acid D (SAD), a mycotoxin causing cleft palate (CP), induces phosphorylation of palatal CREB in vivo...
  101. ncbi The identification of children with cleft palate and sleep disordered breathing using a referral system
    J E MacLean
    Department of Respiratory Medicine, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    Pediatr Pulmonol 43:245-50. 2008
    Cleft palate is associated with an increased risk of sleep disordered breathing (SDB) but the magnitude of this risk and specific risk factors are unclear...

Research Grants72

  1. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..The knock-out animals are perinatal lethal and have a pronounced cleft palate (B. Bjork, D. Beier et a/., in review)...
  2. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..A lecture entitled Palate Development: Molecular Perspectives &Current Understanding will be presented by Robert Greene. Lewis B...
  3. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..cause of genetic and developmental disorders, including mental retardation, autism, schizophrenia, epilepsy, cleft palate and many others...
  4. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..D. at the University of Rochester for work in understanding cleft lip and palate in the spontaneously-occurring Dancer mutant mouse...
  5. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    ..Cleft lip with or without cleft palate (CL[unreadable]P) is one of the most common of these defects, occurring in approximately 1 per 1,000 live births...
  6. Ribosomal Protein Gene Silencing in Neural Crest Stem Cells
    JOHNSON MING YU LIU; Fiscal Year: 2010
    ..of DBA have been linked to mutations in genes encoding ribosomal proteins, however, orofacial anomalies (cleft palate) were found only in patients with RPL5 mutations...
  7. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..D. at the University of Rochester for work in understanding cleft lip and palate in the spontaneously-occurring Dancer mutant mouse...
  8. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..are secondary to oncologic resection, traumatic events or congenital craniofacial malformations such as cleft palate. Current repair treatments such as autologous grafts are restricted by donor site morbidity, tissue shortage, and ..
  9. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri H Beaty; Fiscal Year: 2013
    ..a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL;cleft lip and palate, CLP;and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, Taiwan, and 2 sites in China)...
  10. CLONING OF THE Hol MUTATION
    Licia Selleri; Fiscal Year: 2009
    ..Also, their palate is cleft and the basisphenoid is fused to the basioccipital bone...
  11. Oral Mucins as a Diagnostic Indicator and Therapeutic Treatment for Xerostomia
    DAVID JOHN CULP; Fiscal Year: 2011
    ..Two other mucins have been localized to epithelial cells lining oral tissues such as the cheeks and palate. In preliminary experiments with human salivary gland RNA, we discovered multiple additional mucin transcripts in ..
  12. Function and regulation of Lhx genes in craniofacial development
    Juhee Jeong; Fiscal Year: 2010
    Craniofacial abnormalities involving the first branchial arch derivatives, including the jaw, palate and teeth, are a major class of birth defects in humans...
  13. A Developmental Craniofacial Atlas for the Zebrafish
    Charles B Kimmel; Fiscal Year: 2010
    ..model organism for understanding conserved features of development of the skull, and human disorders such as cleft palate. The atlas will provide a key resource for scientists wishing to discover how the complex anatomy of the zebrafish ..
  14. Genetic Risk for Orofacial Clefts in the Folate/Homocysteine Pathway
    NICHOLAS MARINI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Orofacial clefts, specifically cleft lip and cleft palate, are common and costly congenital anomalies whose etiologies remain largely unknown...
  15. The role of the primitive choana in amniote craniofacial morphogenesis
    John Abramyan; Fiscal Year: 2013
    ..emphasis on identifying putative influences on other key elements of the embryonic oral cavity such as secondary palate formation...
  16. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2013
    ..We hope we have established an environment in which students can explore paths to careers in dental/craniofacial research. ..
  17. SPLUNC1 protein in host defense against Mycoplasma pneumoniae infection
    HONG W CHU; Fiscal Year: 2012
    ..Airway epithelial cells are critical in host defense against the invading pathogens. Palate, lung, and nasal epithelium clone (PLUNC) proteins are a new family of host defense molecules...
  18. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2010
    ..Understanding how neural crest cells develop is important because common birth defects such as cleft lip and palate are caused by abnormal development in this cell type.
  19. Crosslink augmentation to resist snoring and obstructive sleep apnea syndrome
    Thomas P Hedman; Fiscal Year: 2013
    ..due to abnormalities in the geometry of the air passages and the propensity for aberrant deformation of the soft palate. Repeated trauma to the soft palate due to snoring can be expected to increase its passive deformability and ..
  20. Regulation of orofacial ectodermal polarity by the CLP protein, IRF6
    EMILY YIN CHU; Fiscal Year: 2013
    ..factor 6 (IRF6) variants are associated with common isolated forms of cleft lip with or without clefting of the palate (CLP), as well as with dominantly inherited forms of CLP...
  21. A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200
    WARNER KING HUH; Fiscal Year: 2012
    ..of cattle with bovine papillomavirus type 4 (BPV4) L2 11-200 protects against BPV4 challenge on the soft palate. Furthermore, vaccination of rabbits with HPV16 L2 11-200 protects against both cutaneous infection with ..
  22. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..tube function (ETF) and reducing the prevalences of otitis media with effusion (OME) and hearing loss in cleft palate (CP) patients without causing adverse events or having detrimental effects on the other functions affected by the ..
  23. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2013
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
  24. DGAP: Developmental Genome Anatomy Project
    CYNTHIA CASSON MORTON; Fiscal Year: 2013
    ..These anomalies can include isolated defects ranging from cleft lip/palate, abdominal wall defects, limb defects, cardiac abnormalities or mental retardation, or they can occur as part of ..
  25. Leica LMD 7000 Laser Capture Microdissection Microscope
    Siegfried Janz; Fiscal Year: 2013
    ..rates along individual chromosomes;Jeffery Murray and Martine Dunnwald perform genetic studies on cleft lip and palate formation;David Stolz and Aliye Uc examine organ damage in a newly developed pig model of human cystic fibrosis;..
  26. Role of endocytosis by the neural crest in cardio-craniofacial development
    ANNA LUISE KEYTE; Fiscal Year: 2013
    ..variable, but are frequently characterized by congenital heart disease, especially tetralogy of Fallot, and cleft palate. The co-occurrence of birth defects of the heart, face, and structures of the pharynx reflects not only their ..
  27. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
    ..800 live births and is characterized by small lower jaw, improperly positioned tongue and posterior cleft of the palate, which can result in upper airway obstruction and feeding difficulties...
  28. Large Animal Model for Novel Autologous Treatments of Alveolar Clefts
    JOHN ANANDA VAN AALST; Fiscal Year: 2013
    ..consultations secondary to ultrasound diagnoses of craniofacial deformities--primarily clefts of the lip and palate. Because of these changing demographics and the candidate's interest in translational stem cell therapies, ..
  29. Eph/Ephrin signaling in Taste Nerve Targeting
    MICHAEL WILLIAM ROCHLIN; Fiscal Year: 2010
    ..of the proposed work is to determine which Ephs and ephrins are expressed in gustatory epithelia in the tongue and palate and the sensory nerves that innervate them during embryonic development...
  30. Targeting the DNA Damage Response for the Treatment of Herpes Simplex Labialis
    WILLIAM DONEGAN; Fiscal Year: 2013
    ..as herpes simplex labialis (HSL), primary herpetic gingivostomatis, and intraoral vesicles that arise in the hard palate and attached gingival...
  31. MicroRNAs in cleft lip and palate
    JAMES FRANCIS MARTIN; Fiscal Year: 2013
    ..data indicate that miR17-92 mutant embryos have severe craniofacial phenotypes, including cleft lip and palate (CL/P) and mandibular hypoplasia, consistent with the hypothesis that miR17-92 is a Bmp-target in craniofacial ..
  32. The North Carolina Cleft Outcomes Study
    Ronald P Strauss; Fiscal Year: 2013
    ..outcomes, academic achievement, timeliness and use of services (genetics services, speech and language, lip/palate repair and revision surgeries), expenditures, and use and costs of team care...
  33. Shaping the craniofacial skeleton in the zebrafish
    APRIL F DELAURIER; Fiscal Year: 2010
    ..Mef2c is a transcription factor in the endothelinl (ednl) pathway, disruption of which is associated with cleft palate defects in humans...
  34. 2012 Craniofacial Morphogenesis &Tissue Regeneration GRS &GRC
    Robert E Maxson; Fiscal Year: 2012
    ..Non-syndromic disorders that affect the cranial sutures, palate, teeth and jaw are also common...
  35. Molecular characterization of novel loci for orofacial clefting using canine mode
    Danika L Bannasch; Fiscal Year: 2013
    ..They can occur as isolated cases of cleft palate (CPO), or cleft lip with or without cleft palate (CL/P), or in combination with other birth defects...
  36. Growth Factor Signaling in Mouse Palatogensis
    YiPing Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...
  37. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2012
    ..event fails, the consequences can be devastating, resulting in congenital abnormalities as severe as cleft palate or spina bifda...
  38. A role for the methyltransferase NSD3 in neural crest specification and migration
    Bridget T Jacques-Fricke; Fiscal Year: 2013
    ..Common birth defects such as cleft lip and palate result from abnormalities in neural crest cell development...
  39. CRANIOFACIAL MORPHOGENESIS IN ZEBRAFISH
    Charles B Kimmel; Fiscal Year: 2013
    ..zebrafish can teach us much about the nature of the defects in inherited craniofacial disorders such as cleft palate. Three projects are proposed to test specific predictions of hypotheses explaining critical aspects of early ..
  40. The Use of Electropalatography in the Treatment of Apraxia of Speech
    Shannon C Mauszycki; Fiscal Year: 2012
    ..is a custom made acrylic plate embedded with a varying number of electrodes that fits tightly against the upper palate. The electrodes detect tongue to palate contacts and allow contacts to be recorded, stored, and displayed in real ..
  41. Epithelial-mesenchymal interactions in facial patterning
    GAGE D CRUMP; Fiscal Year: 2013
    ..signaling within human arches result in a variety of birth defects, including facial deformities and cleft palate. Whereas major advances have been made in identifying the signaling pathways involved in facial development, how ..
  42. Epithelial PLUNC as a determinant of Airway Mucosal Antimicrobial Activity
    YUANPU PETER DI; Fiscal Year: 2012
    ..One molecule we believe to be critical to epithelially initiated antimicrobial defense is PLUNC (palate, lung and nasal epithelium carcinoma associated) which we co-discovered and originally named SPURT (secretory ..
  43. Role of actin cytoskeleton regulators in craniofacial development and disease
    Shuyi Nie; Fiscal Year: 2013
    ..in their proliferation, migration, or survival lead to numerous diseases and birth defects, including cleft lip/palate, Treacher-Collins syndrome, and DiGeorge syndrome...
  44. Effects of Bolus Accommodation on Swallowing Effort in Healthy Elderly Individual
    Lisa A Lagorio; Fiscal Year: 2011
    ..the fluoroscopic evaluation, participants will wear three data collection sensors: a 3-bulb array affixed to the palate, a surface electromyography electrode affixed on the skin over the sub mental muscles, and a 2...
  45. Role of Irf6 in palatal epithelium
    Youssef A Kousa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The palate separates the oral and nasal cavity and allows breathing to occur alongside eating and drinking...
  46. Epigenetic Regulation in Cranial Neural Crest Development
    Na Hu; Fiscal Year: 2012
    ..neural crest development can lead to a variety of birth defects such as craniofacial defects like cleft lip and palate, heart septation defects, and agangliogenesis of the colon...
  47. Genetic Characterization of a Novel Model of Cleft Palate
    Stephen A Murray; Fiscal Year: 2010
    ..Although an increasing number of genes have been linked to cleft lip and cleft palate, the mechanisms governing orofacial malformations remain unclear...
  48. TGF-BETA SIGNALING IN PALATOGENESIS
    Mark M Urata; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cleft palate is the most common congenital craniofacial anomaly and occurs as an isolated defect as well as a component of syndromic and sequential disorders...
  49. MICROINVASIVE TREATMENT OF SLEEP APNEA WITH THE LINGUAFLEX TISSUE RETRACTOR II
    Ira Sanders; Fiscal Year: 2010
    ..upper airway whose collapse directly contributes to airway obstructions in OSA, namely the tongue base, the soft palate and the lateral pharyngeal walls...
  50. Genetic and Morphometric Analysis of Facial Clefts
    REBECCA MICHELLE GREEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cleft lip (CL) or Cleft lip/palate (CL/P) occurs in about 1 in 700 live births, and while they are treatable, many individuals with these types of deformities will require lifelong care...
  51. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    Carole L Marcus; Fiscal Year: 2012
    ..result primarily in a decrease in the size of the parapharyngeal fat pads, but may also affect tongue and soft palate size...
  52. Transcriptional Targets of PDGF Signaling during Craniofacial Development
    Harish Vasudevan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Craniofacial defects, such as cleft lip and/or palate, are the most prevalent congenital malformations worldwide...
  53. P30 Center in Craniofacial Bone Biology
    Nicola C Partridge; Fiscal Year: 2010
    ..This will advance research into understanding important disease processes such as cleft palate and lead to strategies for the repair of such problems along with Craniofacial injuries caused by cancer, accident ..
  54. Caregiver Responses to Nasoalveolar Molding and Early Cleft Care
    Hillary L Broder; Fiscal Year: 2013
    ..pre-surgical treatment aimed at improving cosmetic and functional outcomes among children with cleft lip and palate (CLP) through early intervention at about one month of age...
  55. Oral Clefts: Moving from Genome Wide Studies Toward Functional Genomics
    Terri H Beaty; Fiscal Year: 2013
    ..This project is designed to follow up evidence from a genome wide study of oral clefts (cleft lip, cleft palate &cleft lip and palate) in a large international study of humans by sequencing specific genes to identify ..
  56. Sleep and Neurobehavioral Performance After Cleft Palate Repair
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    Cleft palate is a highly prevalent craniofacial malformation that affects approximately one in 700 newborns in the U.S...
  57. Characterizing the mechanisms of PDGFRalpha regulation in upper lip development
    Fenglei He; Fiscal Year: 2013
    ..Derived Growth Factor Receptor [unreadable] (PDGFR[unreadable]) signaling have been tightly linked to cleft lip/palate in humans and mice, suggesting an evolutionarily conserved role in craniofacial development...
  58. Molecular Interactions During Neural Crest Formation
    MARTIN IGNACIO GARCIA-CASTRO; Fiscal Year: 2013
    ..crest development and homeostasis result in human pathologies or "neurocristopathies" that include cleft lip/palate, Waardenburg syndrome, and melanoma, amongst others...
  59. Extending the Phenotype of Nonsyndromic Orofacial Clefts
    Mary L Marazita; Fiscal Year: 2012
    Abstract Orofacial clefts (OFCs), particularly nonsyndromic cleft lip with or without cleft palate (NS CL/P) are a major public health problem, affecting one in every 500-1000 births worldwide...
  60. Characterizing early neural crest phosphoregulation using antiphosphatase targets
    Laura S Gammill; Fiscal Year: 2013
    ..is phosphorylated, regulates cell motility (including metastasis), and associates with non-syndromic cleft lip and palate. However, MYH9 has not been characterized in the neural crest...
  61. Super-resolution Reconstruction of Fetal Craniofacial MRI
    ALI GHOLIPOUR-BABOLI; Fiscal Year: 2012
    ..Nevertheless the diagnostic accuracy of sonography for complex craniofacial diseases such as cleft lip and cleft palate, hemifacial microsomia, micrognathia, etc. is extremely low...
  62. A 3-D Interactive Atlas of the Human Skull
    Kevin N Montgomery; Fiscal Year: 2010
    ..collection of pathologies which would demonstrate dramatic bony changes in the skull such as: microcephalia;cleft palate;Paget's disease;cancer;TMJ disorders;etc...
  63. GUSTATORY CHEMOSENSITIVITY OF THE ORAL PALATE
    INGLIS MILLER; Fiscal Year: 1980
    ..Taste buds are present on the oral palates of humans and the human palate is as sensitive to chemical solutions as the tongue...
  64. CLEFT LIP AND PALATE IN LOS ANGELES HISPANICS
    M Spence; Fiscal Year: 1990
    ..the etiology of facial clefts by analyzing family data for the Hispanic population treated by the Cleft Palate Service of Rancho Los Amigos Hospital, Los Angeles County, California...
  65. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  66. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
    Cleft palate is one of the most frequently occurring birth defects in the United States...
  67. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2004
    Non-syndromic clefts of the lip and/or palate are among the most common malformations of the head and neck...
  68. WOUND HEALING AFTER FETAL CLEFT LIP REPAIR
    Leonard Kaban; Fiscal Year: 1990
    Although excellent esthetic and functional results can be achieved with post-natal cleft lip and palate repair, consecutive surgical procedures lead to scar formation and secondary midface growth retardation...
  69. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2001
    Oral clefts (including cleft lip, CL; cleft palate, CP; and cleft lip and palate, CLP) represent a complex and heterogeneous group of crainofacial defects that constitute a major public health burden due to their high prevalence...
  70. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2004
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  71. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    Clefts of the lip and/or palate are among the most common and easily diagnosed birth defects, and can provide a model for complex trait analysis...
  72. An Exploratory Model of Early Speech Intervention for Children with Cleft Palate
    Nancy J Scherer; Fiscal Year: 2010
    Young children with cleft lip and/or palate are at risk for speech and language delays associated with structural deficits despite early surgical repair...