Genomes and Genes
Summary: The structure that forms the roof of the mouth. It consists of the anterior hard palate (PALATE, HARD) and the posterior soft palate (PALATE, SOFT).
Publications202 found, 100 shown here
- Facial and dental characteristics of Padaung women (long-neck Karen) wearing brass neck coils in Mae Hong Son Province, ThailandDonjai Chawanaputorn
Orthodontic Department, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
Am J Orthod Dentofacial Orthop 131:639-45. 2007..Women of the Padaung tribe in Thailand are known to wear brass neck coils (BNC) all their lives. The purpose of this study was to identify the effects of these coils on facial morphology and dental characteristics...
- Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processesHuimin Yu
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA
Development 137:3707-17. 2010..is a recurrent theme in mammalian embryology, and this process plays an integral role in the development of the palate, ventricular septum, neural tube, urethra, diaphragm and eye...
- Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate developmentJong Min Lee
Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University, Seoul, Republic of Korea
Dev Biol 314:341-50. 2008Various cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development...
- Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hairNina Dathan
Centro di Studi di Biocristallografia del CNR, Via Mezzocannone, Naples, Italy
Dev Dyn 224:450-6. 2002..Titf2 null mice exhibit cleft palate and either a sublingual or completely absent thyroid gland...
- TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complexAli Nawshad
Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
J Cell Sci 120:1646-53. 2007Dissociation of medial-edge epithelium (MEE) during palate development is essential for mediating correct craniofacial morphogenesis...
- Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palateLuca Scapoli
Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, University of Bologna, Via Belmeloro, 8, 40126 Bologna, Italy
Hum Mutat 31:794-800. 2010Nonsyndromic cleft lip with or without cleft palate (CL/P) affects approximately 1 in 1,000 births...
- Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypesErwin Pauws
UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH London, UK
Hum Mol Genet 18:4171-9. 2009Craniofacial defects involving the lip and/or palate are among the most common human birth defects. X-linked cleft palate and ankyloglossia results from loss-of-function mutations in the gene encoding the T-box transcription factor TBX22...
- Considerations for free-flap reconstruction of the hard palateN D Futran
Department of Otolaryngology Head and Neck Surgery, University of Washington School of Medicine, Seattle 98195 6515, USA
Arch Otolaryngol Head Neck Surg 125:665-9. 1999To evaluate the use of microvascular free-tissue transfers in the reconstruction of hard palate defects.
- Mechanism of secalonic acid D-induced inhibition of transcription factor binding to cyclic AMP response element in the developing murine palateUmesh M Hanumegowda
Department of Veterinary Biomedical Sciences, University of Missouri, W148 Vet Med Bldg, 1600 E Rollins, Columbia, Missouri 65211, USA
Toxicol Sci 70:55-62. 2002..Secalonic acid D (SAD), a mycotoxin causing cleft palate (CP), induces phosphorylation of palatal CREB in vivo...
- Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large geneG Caruana
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
Mol Cell Biol 21:1475-83. 2001..exhibit growth retardation in utero, have hypoplasia of the premaxilla and mandible, have a cleft secondary palate, and die perinatally...
- A blinded randomized controlled trial comparing lignocaine and placebo administration to the palate for removal of maxillary third molarsM E Badcock
School of Dental Science, University of Melbourne, 720 Swanston Street, Parkville, VIC 3010, Australia Private practice, Melbourne, Australia
Int J Oral Maxillofac Surg 36:1177-82. 2007..2 mL of lignocaine without vasoconstrictor was administered to one side of the palate and the same amount of normal saline administered to the other side...
- The identification of children with cleft palate and sleep disordered breathing using a referral systemJ E MacLean
Department of Respiratory Medicine, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
Pediatr Pulmonol 43:245-50. 2008Cleft palate is associated with an increased risk of sleep disordered breathing (SDB) but the magnitude of this risk and specific risk factors are unclear...
- [Necrotizing sialometaplasia of the palate. Literature report of 3 new cases]A Schmidt Westhausen
Dtsch Z Mund Kiefer Gesichtschir 15:30-4. 1991In this study 3 cases diagnosed as necrotizing sialometaplasia (NS) of the palate are described and discussed together with 106 other cases cited in the literature...
- A clinicopathologic study of malignant lymphomas of the nose, paranasal sinuses, and hard palate, including cases of lethal midline granulomaH Ratech
James Irvine Center for the Study of Leukemia and Lymphoma, Division of Pathology, Duarte, California
Cancer 64:2525-31. 1989Malignant lymphomas of the nose, paranasal sinuses, and hard palate show marked clinicopathologic, immunologic, and prognostic diversity...
- Dental CT and orthodontic implants: imaging technique and assessment of available bone volume in the hard palateAndre Gahleitner
Department of Radiology Osteology and MR, Medical School, University of Vienna, Wahringer Gurtel 18, A 1090, Austria
Eur J Radiol 51:257-62. 2004..The aim of this study was to determine whether dental CT could serve as a tool to locate the optimal size and position for orthodontic implant placement...
- ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesisR Shalom-Feuerstein
INSERM U898, University of Nice, 28 Avenue Valombrose, Nice, France
Cell Death Differ 18:887-96. 2011..These data highlight the earliest recognized action of ΔNp63 in the induction epidermal morphogenesis at E11.5. In the absence of p63, a mesodermal program is activated while epidermal morphogenesis does not initiate...
- Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferationHiroyuki Enomoto
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
Development 137:4029-38. 2010..overlap of Adamts9 with Adamts20 was identified using Adamts9(+/-);bt/bt mice, which have a fully penetrant cleft palate. Palate closure was delayed, although eventually completed, in both Adamts9(+/-);bt/+ and bt/bt mice, ..
- Histopathological findings of cleft palate in rat embryos induced by triamcinolone acetonideSatoshi Furukawa
Biological Research Laboratories, Nissan Chemical Industries, Ltd, Minamisaitama, Saitama, Japan
J Vet Med Sci 66:397-402. 2004Triamcinolone acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice...
- Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethalityM Parrish
Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Mol Cell Biol 24:7102-12. 2004..the neural ectoderm and primitive streak and subsequently in the brain, peripheral nerves, spinal cord, limb buds, palate, heart, and otic vesicles. We have generated a targeted disruption of Sall3 in mice...
- TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusionConsuelo Tudela
Departamento de Ciencias Morfológicas I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
Int J Dev Biol 46:333-6. 2002Transforming growth factor-beta3 (TGF-beta3) plays a critical role during palate development, since mutations of the TGF-beta3 gene give rise to cleft palate in both humans and mice...
- Speech development of children with cleft palate before and after palatal surgeryCourtney E Jones
Primary Children's Medical Center, Salt Lake City, Utah, USA
Cleft Palate Craniofac J 40:19-31. 2003OBJECTIVE: This study examined the speech production abilities of children with cleft palate before and after palate repair...
- Response of Merkel cells in the palatal rugae to the continuous mechanical stimulation by palatal plateKen Ishizaki
Department of Complete Denture Prosthodontics, Tokyo Dental College, Chiba, Japan
Somatosens Mot Res 23:63-72. 2006..The palatal plate was made of adhesive resin and it was set on the palate of the animal. To exert a continuous pressure, a 0...
- A dosage-dependent role for Spry2 in growth and patterning during palate developmentIan C Welsh
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
Mech Dev 124:746-61. 2007The formation of the palate involves the coordinated outgrowth, elevation and midline fusion of bilateral shelves leading to the separation of the oral and nasal cavities...
- Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesisCatherine Dode
Institut Cochin, INSERM U567, Universite Rene Descartes, Paris, France
Hum Mutat 28:97-8. 2007..Moreover, the presence of cleft palate in a patient carrying the p.E324X change shows that FGFR1c is important for palate morphogenesis too.
- PCNA in palate and tongue mucosal dysplastic lesions induced by topically applied 4NQO in desalivated ratI Kaplan
Department of Oral Pathology and Oral Medicine The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University, Tel Aviv Israel
Med Oral 7:336-43. 2002..The purpose of this study was to follow the changes induced by the carcinogen at the molecular level, as well as the effect of lack of saliva on these changes...
- Biological mechanisms in palatogenesis and cleft palateL Meng
Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
J Dent Res 88:22-33. 2009Clefts of the palate are common birth defects requiring extensive treatment. They appear to be caused by multiple genetic and environmental factors during palatogenesis...
- Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomaliesAlexander W Wyatt
Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
Hum Mutat 31:781-7. 2010..eye anomalies and a range of systemic abnormalities, including developmental delay, deafness, scoliosis, and cleft palate. We determined that BMP7 is expressed in the developing eye, brain, and ear in human embryos in a manner ..
- Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formationGiovanni Levi
Evolution des Regulations Endocriniennes, CNRS UMR5166, Museum national d histoire naturelle, Paris, France
Mech Dev 123:3-16. 2006..and middle ear), synergistically (deposition of bone tissue) or converging on the same morphogenetic process (palate growth and closure)...
- Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndromeAlexandra S Knight
Faculty of Life Sciences and School of Dentistry, University of Manchester, Manchester, United Kingdom
Dev Dyn 235:1441-7. 2006Development of the lip and palate involves a complex series of events that are frequently disturbed resulting in the congenital anomalies cleft lip and cleft palate...
- A specific requirement for PDGF-C in palate formation and PDGFR-alpha signalingHao Ding
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Nat Genet 36:1111-6. 2004..perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos...
- Cleft palate: players, pathways, and pursuitsJeffrey C Murray
Department of Pediatrics and Craniofacial Anomalies Research Center, University of Iowa, Iowa City, Iowa 52242, USA
J Clin Invest 113:1676-8. 2004Cleft lip and palate is a common human birth defect, and its causes are being dissected through studies of human populations and through the use of animal models...
- Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palateXiao Mei Cui
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Dev Biol 278:193-202. 2005..In the present study, the cleft palate phenotype in Tgf-beta3-/- mice was rescued by overexpression of a Smad2 transgene in Keratin 14-synthesizing MEE ..
- Terminal differentiation of palatal medial edge epithelial cells in vitro is not necessarily dependent on palatal shelf contact and midline epithelial seam formationToshiya Takigawa
Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Int J Dev Biol 48:307-17. 2004During fusion of the mammalian secondary palate, it has been suggested that palatal medial edge epithelial (MEE) cells disappear by means of apoptosis, epithelial-mesenchymal transformation (EMT) and epithelial cell migration...
- An innovative management of detached palatal mucoperiosteal flap from the hard palate (hanging palate)Karoon Agrawal
Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
Plast Reconstr Surg 115:875-9. 2005
- TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate developmentAli Nawshad
Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, B 1, Room 342, Boston, MA 02115 6092, USA
J Cell Biol 163:1291-301. 2003..We show with antisense beta-catenin oligonucleotides that up-regulated LEF1 is not activated by beta-catenin in palate EMT...
- Regulation of Twist, Snail, and Id1 is conserved between the developing murine palate and toothRitva Rice
Department of Craniofacial Development, King s College London, UK
Dev Dyn 234:28-35. 2005The development of both the tooth and palate requires coordinated bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) signalling between epithelial and mesenchymal tissues...
- Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformationForugh Vaziri Sani
Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Medicinaregatan 12F, SE 405 30 Goteborg, Sweden
Dev Biol 285:490-5. 2005..fusion of the palatine shelves is a crucial event, the failure of which results in the birth defect, cleft palate. The fate of the midline epithelial seam (MES), which develops transiently upon contact of the two palatine ..
- Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palateLing Yu
Division of Developmental Biology, Department of Cell and Molecular Biology, and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
Development 132:4397-406. 2005..We report the restricted expression of Shox2 in the anterior domain of the secondary palate in mice and humans...
- TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusionXiao Mei Cui
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
Dev Dyn 227:387-94. 2003..Phospho-SMAD3 was not detectable in palate during normal palatal fusion...
- Expression patterns of Hedgehog signalling pathway members during mouse palate developmentRitva Rice
Department of Craniofacial Development, King s College London, Floor 28 Guy s Tower, St Thomas Street, London SE1 9RT, UK
Gene Expr Patterns 6:206-12. 2006..No differences were found in the expression patterns of Hh pathway members along the anterior-posterior axis of the developing palate.
- Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesisAlexander Herr
Max Planck Institute for Molecular Genetics, Berlin, Germany
Dev Dyn 226:579-86. 2003..Mutations in TBX22 have been reported in families with X-linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown...
- Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palateRitva Rice
Departments of Craniofacial Development and Orthodontics, King s College, London, United Kingdom
J Clin Invest 113:1692-700. 2004Classical research has suggested that early palate formation develops via epithelial-mesenchymal interactions, and in this study we reveal which signals control this process...
- Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate developmentXun Xu
Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Dev Cell 15:322-9. 2008..In this study, we investigated the role of TGF-beta signaling in tooth and palate development and noted that conditional inactivation of Smad4 in oral epithelium results in much milder phenotypes ..
- Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced cleftingM A Montenegro
Department of Morphology, Biomedical Ciencies Institute, Faculty of Medicine, University of Chile
J Craniofac Genet Dev Biol 20:137-43. 2000..proteins, keratin and vimentin and, one adhesion molecule, cadherin in different stages of developing secondary palate in two strains of mice with different H-2 backgrounds was undertaken to investigate differences between a strain ..
- Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lungW M Weston
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 274:13698-703. 1999..In situ hybridization analysis shows discrete regions of expression associated with the palate, nasal septum, and nasal conchae...
- Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closureP J Miettinen
Department of Growth and Development, University of California, San Francisco 94143 0452, USA
Nat Genet 22:69-73. 1999Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,000 live births among ..
- Unilateral complete cleft lip and palate repair using lip adhesion and passive alveolar molding applianceB Cho
Department of Plastic and Reconstructive Surgery, Kyungpook National University Hospital, Samduk 2 ga, 50, Taegu, 700 421, Korea
J Craniofac Surg 12:148-56. 2001To manage a unilateral complete cleft lip and palate, lip adhesion along with the positioning of a passive alveolar molding appliance was performed in infants at 3 to 6 weeks of age...
- Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8Y Zhao
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 96:15002-6. 1999Formation of the mammalian secondary palate is a highly regulated and complex process whose impairment often results in cleft palate, a common birth defect in both humans and animals...
- Developmental dependency of Merkel endings on trks in the palateH Ichikawa
Second Department of Oral Anatomy and Biodental Research Center, Okayama University Dental School, Okayama 700, Japan
Brain Res Mol Brain Res 88:171-5. 2001Immunohistochemistry for protein gene product 9.5 was performed on Merkel cells in the palate of wildtype and knockout mice for trkA, trkB or trkC. In wildtype mice, numerous Merkel cells were observed at the top of anterior four rugae...
- Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowthYu Lan
Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Development 136:1387-96. 2009The mammalian secondary palate arises by outgrowth from the oral side of the paired maxillary processes flanking the primitive oral cavity...
- The etiopathogenesis of cleft lip and cleft palate: usefulness and caveats of mouse modelsAmel Gritli-Linde
Department of Oral Biochemistry, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
Curr Top Dev Biol 84:37-138. 2008Cleft lip and cleft palate are frequent human congenital malformations with a complex multifactorial etiology...
- Sensory nerve endings in the hard palate and papilla incisiva of the goatZ Halata
Department of Functional Anatomy, Institute of Anatomy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Exp Brain Res 129:218-28. 1999The sensory innervation of the papilla incisiva in the hard palate of the domestic goat was studied with light and electron microscopy, supplemented by electrophysiological studies of free nerve endings. The goat lacks incisor teeth...
- The role of twist during palate developmentWenli Yu
Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
Dev Dyn 237:2716-25. 2008..However, decreasing Twist with siRNA did not completely block palate fusion, indicating that the function of Twist may be duplicated by other transcription factors.
- A comparison of babbling and speech at pre-speech level, 3, and 5 years of age in children with cleft lip and palate treated with delayed hard palate closureA Lohmander-Agerskov
Departments of Logopedics and Phoniatrics, Orthodontics, and Plastic Surgery, Goteborg University, Goteborg, Sweden
Folia Phoniatr Logop 50:320-34. 1998Babbling and speech in 21 children with cleft palate were compared at pre-speech level, 3, and 5 years of age...
- A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney developmentYu Lan
Center for Oral Biology, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Genesis 45:618-24. 2007Mammalian palate development is a multistep process, involving initial bilateral downward outgrowth of the palatal shelves from the oral side of the maxillary processes, followed by stage-specific palatal shelf elevation to the horizontal ..
- Differential expression of insulin-like growth factors I and II (IGF I and II), mRNA, peptide and binding protein 1 during mouse palate development: comparison with TGF beta peptide distributionM W Ferguson
Department of Cell and Structural Biology, University of Manchester, UK
J Anat 181:219-38. 1992Development of the mammalian secondary palate involves a series of epithelial mesenchymal interactions: during one of these, a mesenchymal signal specifies regionally distinct palatal epithelial differentiation...
- Menin is required in cranial neural crest for palatogenesis and perinatal viabilityKurt A Engleka
Department of Cell and Developmental Biology and the Cardiovascular Institute, University of Pennsylvania, 1154 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA
Dev Biol 311:524-37. 2007..inactivation of menin in Pax3- or Wnt1-expressing neural crest cells leads to perinatal death, cleft palate and other cranial bone defects, which are associated with a decrease in p27(kip1) expression...
- Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interactionV Kaartinen
Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA
Nat Genet 11:415-21. 1995..Unlike other null mutants with cleft palate, TGF-beta 3-/- mice lack other concomitant craniofacial abnormalities...
- Bulging medial edge epithelial cells and palatal fusionC Martinez-Alvarez
Departamento de Ciencias Morfológicas I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
Int J Dev Biol 44:331-5. 2000..and 16 most TGF-beta3 +/- and +/+ embryos showed total palatal fusion, whilst all TGF-beta3 null mutants had cleft palate: the middle third of the palatal shelves had adhered, leaving an anterior and posterior cleft...
- Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusionC L Brunet
Division of Cells, Immunology and Development, School of Biological Sciences, University of Manchester, United Kingdom
Int J Dev Biol 39:345-55. 1995..Prevention of mature TGF-beta 3 activity during a specific time window of development in palate organ cultures, either by antisense oligodeoxynucleotides or neutralizing antibody, resulted in failure of palate ..
- Development of anterior gustatory epithelia in the palate and tongue requires epidermal growth factor receptorHanshi Sun
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 3127 Natural Science Building, Ann Arbor, Michigan 48109 1048, USA
Dev Biol 242:31-43. 2002..bdnf(-/-) mice had similar reductions in the total number of taste buds on the anterior portions of the tongue and palate. Nonetheless, there were significant differences in their gustatory phenotypes...
- Localization of types I and III collagen and fibronectin in the developing mouse palatal shelvesY Ohsaki
Second Department of Oral Anatomy, Kyushu University, Fukuoka, Japan
Acta Anat (Basel) 153:161-7. 1995..elevation, type I collagen showed denser localization on the nasal side than on the oral side of the middle hard palate region. Such a distribution extended as far as the posterior hard palate region but not to the soft palate region...
- Differential expression of TGF beta isoforms in murine palatogenesisD R Fitzpatrick
Duncan Guthrie Institute of Medical Genetics, University of Glasgow, Yorkhill, UK
Development 109:585-95. 1990..of genes encoding transforming growth factors (TGFs) beta 1, beta 2 and beta 3 during development of the secondary palate in the mouse from 11.5 to 15.5 days postcoitum using in situ hybridisation...
- Sagittal airway dimensions following maxillary protraction: a pilot studyKorkmaz Sayinsu
Faculty of Dentistry, Yeditepe University, Istanbul, Turkey
Eur J Orthod 28:184-9. 2006..71 +/- 3.35 and 3.03 +/- 2.37 mm, respectively. These results demonstrated that limited maxillary widening together with protraction of the maxilla, improve nasopharyngeal but not oropharyngeal airway dimensions in the short term...
- Changes of vertical skeletal morphology in patients with complete unilateral and bilateral cleft lip and palateJörg A Lisson
Department of Orthodontics, University Hospital Saarland, Homburg Saar, Germany
Cleft Palate Craniofac J 42:490-4. 2005..The aim of this retrospective investigation was to qualify and quantify changes of the vertical skeletal morphology during puberty in cleft patients compared with an age-matched noncleft control...
- Use of onplants as stable anchorage for facemask treatment: a case reportHe Hong
Key Lab for Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan, China
Angle Orthod 75:453-60. 2005..These results suggest that onplants can be used as an extremely stable anchorage for maxillary orthopedic facemask treatment...
- Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement without reductionIoanna K Gidarakou
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Angle Orthod 74:684-90. 2004..This study suggests that subjects with BDDN may manifest altered craniofacial morphology. The clinician should be aware of that possibility, especially for the growing patients and the surgical candidates...
- [Maxillary sequelae in cleft patients. Causes of maxillary hypoplasia and possible prevention]H Benateau
AP HP, Hopital d Enfants Armand Trousseau, Service de Chirurgie Maxillo Faciale et Chirurgie Plastique, 75012 Paris, France
Rev Stomatol Chir Maxillofac 108:297-300. 2007..retrusion can be a syndromic outcome, the growth failure is also a consequence of the primary surgery of the palate, alveolar cleft, or lip...
- Changes in occlusion and maxillary dental arch dimensions in adults with treated unilateral complete cleft lip and palate: a follow-up studyAgneta Marcusson
Department of Dentofacial Orthopaedics, University Hospital, , Sweden
Eur J Orthod 26:385-90. 2004..the occlusion and maxillary dental arch dimensions in adults with repaired complete unilateral cleft lip and palate (UCLP) and to investigate the patterns of change in early adulthood...
- Maxillary morphology in obstructive sleep apnea: a cephalometric and model studyAma Johal
Department of Orthodontics, Queen Mary s College, University of London, London, UK
Angle Orthod 74:648-56. 2004..05). The PNS-posterior pharyngeal wall was shorter (P < .05) and the soft palate longer in female OSA subjects (P < .05)...
- The effect of Frankel II and modified twin block appliances on the 'C'-axis: the growth vector of the dentomaxillary complexStanley Braun
Vanderbilt University Medical Center, Nashville, TN, USA
Angle Orthod 74:749-53. 2004..Favorable changes observed in the correction of Class II malocclusions are likely because of dentoalveolar alterations buttressed by favorable mandibular growth...
- Comparison of titanium and resorbable copolymer fixation after Le Fort I maxillary impactionWalinder S Dhol
University of Toronto, Toronto, Ontario, Canada
Am J Orthod Dentofacial Orthop 134:67-73. 2008..The purpose of this study was to investigate the stability of a resorbable copolymer as a potential alternative to titanium for fixation of Le Fort I maxillary impaction...
- A modified procedure for velopharyngeal sphincteroplasty in primary cleft palate repair and secondary velopharyngeal incompetence treatment and its preliminary resultsNingxin Cheng
Department of Plastic Surgery, Guangzhou Medical College, Guangzhou First Municipal People s Hospital, 1 Panfu Road, Guangzhou 510180, People s Republic of China
J Plast Reconstr Aesthet Surg 59:817-25. 2006..To improve the surgical treatment for cleft palate and secondary velopharyngeal incompetence (VPI), a carefully designed modified procedure for primary palatoplasty ..
- Maxillary and mandibular dentoalveolar heights of French-Canadians 10 to 15 years of agePeter H Buschang
Department of Orthodontics, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, Texas 75124, USA
Angle Orthod 78:70-6. 2008..To establish reference data for anterior and posterior dentoalveolar heights of growing French-Canadians with untreated normal occlusions and malocclusions...
- Bite force and maxillofacial morphology in patients with Duchenne-type muscular dystrophyKoichiro Ueki
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
J Oral Maxillofac Surg 65:34-9. 2007..The purpose of this study is to evaluate maxillofacial morphology and bite force in patients with severe Duchenne-type myodystrophy...
- Assessment of bone resorption after secondary alveolar bone grafting using three-dimensional computed tomography: a three-year studyMatthias Feichtinger
Department of Oral and Maxillofacial Surgery, Medical University of Graz, Graz, Austria
Cleft Palate Craniofac J 44:142-8. 2007..grafting plays an important role in the dental rehabilitation of patients with clefts of the lip, alveolus, and palate. A major complication of this surgical technique is resorption of the grafted bone transplant...
- Involvement of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in miceJunko Okano
Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
Toxicol Appl Pharmacol 221:42-56. 2007..On the other hand, exogenous RA could cause cleft palate in offspring when it is given to pregnant animals at either the early or late phases of palatogenesis, but the ..
- Dentofacial growth in patients with Sotos syndromeKunio Takei
Division of Orthodontics, Department of Clinical Oral Health Science, Tokyo Dental College, Tokyo, Japan
Bull Tokyo Dent Coll 48:73-85. 2007..The maxillofacial characteristics are metopic protrusion, a high and narrow palate and a tapered mandible...
- A digital approach to photographing and measuring cleft lip and palate dental study castsNicky Goodfellow
Medical Illustration Services, Perth Royal Infirmary, Jeanfield Road, Perth PH1 1NX, UK
J Vis Commun Med 30:60-71. 2007..a measurably accurate image of a dental cast arch, in order to assist the outcome assessments of cleft lip and palate surgery. It describes the measurement techniques, and discusses the factors affecting reproducibility...
- Use of the centroid method of occlusion for studying the vertical and horizontal relationship of the mandible and maxillaSatoru Murata
Murata Orthodontic Clinic, Toyotetu Terminal Building 3F, 1 46 1 Ekimaeohdori, Toyohashi 440 0888, Japan
Eur J Orthod 29:600-4. 2007..The analytical method is also unaffected by gnathostatic differences according to Angle classification...
- Morphologic and management characteristics of individuals with unilateral cleft lip and palate who required maxillary advancementSnehlata Oberoi
Center for Craniofacial Anomalies, Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA 94143 0442, USA
Cleft Palate Craniofac J 45:42-9. 2008To delineate factors that may contribute to maxillary hypoplasia requiring maxillary advancement surgery in individuals with nonsyndromic unilateral cleft lip and palate (UCLP).
- Development of cephalometric norms using a unified facial and dental approachGregory Anderson
Section of Orthodontics, The Ohio State University, Columbus, 43210, USA
Angle Orthod 76:612-8. 2006....
- Anatomy of greater palatine foramen and canal and pterygopalatine fossa in Thais: considerations for maxillary nerve blockD Methathrathip
Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand
Surg Radiol Anat 27:511-6. 2005..The GPF was 16.2+/-1.3 mm lateral to the median sagittal plane of the hard palate, 2.1+/-1.3 mm anterior to the posterior border of the hard palate and 5.1+/-1...
- Long-term effects of palate repair on craniofacial morphology in patients with unilateral cleft lip and palateYu-Fang Liao
Department of Dentistry, Craniofacial Center, and Sleep Center, Chang Gung Memorial Hospital, Taipei, Taiwan
Cleft Palate Craniofac J 42:594-600. 2005OBJECTIVE: To identify the long-term effects of palate repair on craniofacial growth in patients with unilateral cleft lip and palate (UCLP). DESIGN: Retrospective cross-sectional study. SETTING: Sri Lankan Cleft Lip and Palate Project...
- Validity and reproducibility of cephalometric measurements obtained from digital photographs of analogue headfilmsSimonas Grybauskas
Institute of Odontology, Faculty of Medicine, Vilnius University, Zalgirio 115, Vilnius LT 08217, Lithuania
Stomatologija 9:114-20. 2007..Digital photography could be a fast and inexpensive method of digital capture of analogue cephalograms for use in digital cephalometry...
- Glenoid fossa position in Class II malocclusion associated with mandibular retrusionVeronica Giuntini
Department of Orthodontics, University of Florence, Florence, Italy
Angle Orthod 78:808-12. 2008..To assess the position of the glenoid fossa in subjects with Class II malocclusion associated with mandibular retrusion and normal mandibular size in the mixed dentition...
- Treatment protocol for unilateral cleft lip and palate patients: questioned by two case reportsMedhat Aly
School of Dentistry, Katholieke Universiteit Leuven, Belgium
Aust Orthod J 21:137-48. 2005..The types and severity of clefts as well as palatal development and growth in children with repaired cleft lip and palate deformities can vary greatly...
- Fixed presurgical orthopaedics for bilateral cleft lip and palateNajeeb Abu-Rub
School of Dental Sciences, University Sains Malaysia, Kota Baru, Malaysia
Aust Orthod J 21:39-43. 2005..has been employed since the 1950s as an adjunctive neonatal therapy for the correction of cleft lip and palate. It is accepted that presurgical orthopaedic plates facilitate lip repair and balanced orofacial growth...
- Accuracy of a LeFort I maxillary osteotomySteven Semaan
Dental School, Oral Health Centre of Western Australia, The University of Western Australia, Nedlands, Western Australia, Australia
Angle Orthod 75:964-73. 2005..Overall, 66% of the results were within two mm of prediction and 26% of the results were within one mm of prediction. A LeFort I maxillary osteotomy can be an accurate procedure with a wide range of discrepancy...
- Early postnatal development of the mandible in children with isolated cleft palate and children with nonsyndromic Robin sequenceJ Eriksen
Department of Pediatric Dentistry and Clinical Genetics, School of Dentistry, University of Copenhagen, , DK-2200 Copenhagen N, Denmark
Cleft Palate Craniofac J 43:160-7. 2006..OBJECTIVE: Analysis of early postnatal mandibular size and growth velocity in children with untreated isolated cleft palate (ICP), nonsyndromic Robin sequence (RS), and a control group of children with unilateral incomplete cleft lip (..
- Surgically assisted rapid maxillary expansion compared with orthopedic rapid maxillary expansionAyse T Altug Atac
Department of Orthodontics, School of Dentistry, Ankara University, Besevler Ankara 06500, Turkey
Angle Orthod 76:353-9. 2006..Clinically, there is no difference in patient response between the RME and SARME groups. The only difference between the groups was their indication for RME or SARME, which is based on the age and skeletal maturation of the patient...
- Experimental induction of palate shelf elevation in glutamate decarboxylase 67-deficient mice with cleft palate due to vertically oriented palatal shelfSachiko Iseki
Department of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo 113 8549, Japan
Birth Defects Res A Clin Mol Teratol 79:688-95. 2007..Unexpectedly, inactivation of GAD67 induces cleft palate in mice...
- The effects of nitanium maxillary expander appliances on dentofacial structuresAli Ihya Karaman
Selcuk University, Faculty of Dentistry, Department of Orthodontics, Konya, Turkey
Angle Orthod 72:344-54. 2002..It was clinically observed that the posterior cross-bite and mesiopalatal rotation of the upper first molars were improved and that the crowns of these teeth were moved slightly to the distal side...
- Morphology and affinities of new hominin cranial remains from Member 4 of the Sterkfontein Formation, Gauteng Province, South AfricaCharles A Lockwood
Institute of Human Origins and Department of Anthropology, Arizona State University, Tempe, Arizona 85287, USA
J Hum Evol 42:389-450. 2002..africanus. However, two specimens document the possibility that a second, possibly new species is represented among the Member 4 hominins, although such a species is difficult to characterize on cranial evidence alone...
- Occlusal relationship in patients with bilateral cleft lip and palate during the mixed dentition stage: does neonatal maxillary arch configuration predetermine outcome?Chad A Perlyn
Cleft Palate and Craniofacial Deformities Institute, St Louis Children s Hospital, St Louis, Missouri 63110, USA
Cleft Palate Craniofac J 39:317-21. 2002To determine whether there is any correlation between initial maxillary arch dysmorphology patterns in complete bilateral cleft lip/palate (BCLP) and the subsequent occlusal relationship in early mixed dentition.
- Panoramic radiographs: a tool for investigating skeletal patternM Okan Akcam
Department of Orthodontics, School of Dentistry, Ankara University, Besevler, Ankara 06500, Turkey
Am J Orthod Dentofacial Orthop 123:175-81. 2003....
- Effect of mandibular setback surgery on the posterior airway sizeMaija Liukkonen
Department of Oral Development and Orthodontics, Institute of Dentistry, University of Turku, Finland
Int J Adult Orthodon Orthognath Surg 17:41-6. 2002..Therefore, large anteroposterior discrepancies should be corrected by combined maxillary and mandibular osteotomies...
- Duration of nutritive and nonnutritive sucking behaviors and their effects on the dental arches in the primary dentitionJohn J Warren
College of Dentistry, The University of Iowa, Iowa City 52242 1010, USA
Am J Orthod Dentofacial Orthop 121:347-56. 2002....
- Palate height: another indicator of surgical outcome in unilateral cleft lip and palate?Om P Kharbanda
Division of Orthodontics, Department of Dental Surgery, All India Institute of Medical Sciences New Delhi, India
Cleft Palate Craniofac J 39:308-11. 2002To determine whether palate height and maxillary arch depth are systematically related to the surgical center at which primary repair in unilateral cleft lip and palate (UCLP) was carried out.
- A survey of cleft lip and palate management taught in training programs in KoreaTaik Jong Lee
Department of Plastic Surgery, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
Cleft Palate Craniofac J 40:80-3. 2003..A national survey was conducted to obtain an overall view of the status, assess changes in trends of cleft management, and study new categories of interest...
- A long-term retrospective outcome assessment of facial growth, secondary surgical need, and maxillary lateral incisor status in a surgical-orthodontic protocol for complete cleftsSheldon W Rosenstein
Cleft Lip and Palate Program at Children s Memorial Hospital, Chicago, Ill, USA
Plast Reconstr Surg 111:1-13; discussion 14-6. 2003In 1965, the cleft palate team at Children's Memorial Hospital embarked on a new surgical-orthodontic protocol in the habilitation of newborn complete cleft lip and palate cases...
- Quality of Life in Children with CleftHillary Broder; Fiscal Year: 2009..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
- Quality of Life in Children with CleftHillary L Broder; Fiscal Year: 2010..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
- Quality of Life in Children with CleftHillary L Broder; Fiscal Year: 2010..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
- EFFECTS OF RETINOIDS ON SQUAMOUS CELL CARCONOMASLorraine Gudas; Fiscal Year: 1993..The normal human epithelial cell strains that will be analyzed include those from the soft palate, floor of mouth, buccal mucosa, ventral tongue, gingiva, hard palate, and facial epidermis...
- INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTSTerri H Beaty; Fiscal Year: 2010..a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL;cleft lip and palate, CLP;and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, Taiwan, and 2 sites in China)...
- INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTSTerri Beaty; Fiscal Year: 2009..a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL; cleft lip and palate, CLP; and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, Taiwan, and 2 sites in China)...
- Health outcomes and improved phenotypic characterization of cleft lip and palateGEORGE WEHBY; Fiscal Year: 2007Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
- Health outcomes and improved phenotypic characterization of cleft lip and palateGEORGE WEHBY; Fiscal Year: 2009Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
- Speech Intelligibility Testing in Children with Repaired Cleft PalateDavid Zajac; Fiscal Year: 2007Cleft palate is one of the most frequently occurring birth defects in the United States...
- Effects of oral clefts on birth outcomes and cleft risks due to maternal smokingGEORGE WEHBY; Fiscal Year: 2007Cleft lip and/or palate (CL/P) is a common birth defect with a complex ideology and large health burden. The effects of CL/P on birth outcomes such as low birth weight and prematurity have been understudied...
- Eustachian Tube Form/Function in Cleft Lip and PalateAnil Gungor; Fiscal Year: 2004Non-syndromic clefts of the lip and/or palate are among the most common malformations of the head and neck...
- MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATEJeffrey Murray; Fiscal Year: 1993..cycle of this proposal the investigators applied these techniques to a common sentinel birth defect--cleft lip and palate. These studies allowed identification of the association of a candidate gene, transforming growth factor alpha (..
- VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERYWilliam Williams; Fiscal Year: 2004The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
- Gene-enviornment interactions in facial cleftsKaare Christensen; Fiscal Year: 2006Clefts of the lip and/or palate are among the most common and easily diagnosed birth defects, and can provide a model for complex trait analysis...
- Skin Regeneration: Cellular & Molecular MechanismsHERMANN PETER LORENZ; Fiscal Year: 2010Cleft lip and palate is a major health problem because of the functional defect produced. Furthermore, surgical reconstruction results in lip and palate scarring, which inhibits facial growth and oral function...
- Skin Regeneration: Cellular & Molecular MechanismsHERMANN LORENZ; Fiscal Year: 2009Cleft lip and palate is a major health problem because of the functional defect produced. Furthermore, surgical reconstruction results in lip and palate scarring, which inhibits facial growth and oral function...
- Functional Outcomes of Cleft Lip SurgeryCARROLL TROTMAN; Fiscal Year: 2004DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...