palate

Summary

Summary: The structure that forms the roof of the mouth. It consists of the anterior hard palate (PALATE, HARD) and the posterior soft palate (PALATE, SOFT).

Top Publications

  1. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
  2. pmc Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development
    Jeffrey O Bush
    Department of Cell and Tissue Biology and Program in Craniofacial and Mesenchymal Biology, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 139:231-43. 2012
  3. ncbi Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
    Zunyi Zhang
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 129:4135-46. 2002
  4. ncbi Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    V Kaartinen
    Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA
    Nat Genet 11:415-21. 1995
  5. ncbi Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
    Yoshihiro Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 130:5269-80. 2003
  6. doi Biological mechanisms in palatogenesis and cleft palate
    L Meng
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Dent Res 88:22-33. 2009
  7. ncbi Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation
    Giovanni Levi
    Evolution des Regulations Endocriniennes, CNRS UMR5166, Museum national d histoire naturelle, Paris, France
    Mech Dev 123:3-16. 2006
  8. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
  9. pmc Mesenchymal cell remodeling during mouse secondary palate reorientation
    Jiu Zhen Jin
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville, Louisville, Kentucky
    Dev Dyn 239:2110-7. 2010
  10. ncbi Pathogenesis of cleft palate in TGF-beta3 knockout mice
    Y Taya
    Division of Cells, Immunology and Development, School of Biological Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Development 126:3869-79. 1999

Detail Information

Publications250 found, 100 shown here

  1. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
    Mice lacking TGF-beta 3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and ..
  2. pmc Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development
    Jeffrey O Bush
    Department of Cell and Tissue Biology and Program in Craniofacial and Mesenchymal Biology, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 139:231-43. 2012
    ..The complexity of control of palatogenesis is reflected by the common occurrence of cleft palate in humans...
  3. ncbi Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
    Zunyi Zhang
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 129:4135-46. 2002
    Cleft palate, the most frequent congenital craniofacial birth defects in humans, arises from genetic or environmental perturbations in the multi-step process of palate development...
  4. ncbi Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    V Kaartinen
    Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA
    Nat Genet 11:415-21. 1995
    ..Unlike other null mutants with cleft palate, TGF-beta 3-/- mice lack other concomitant craniofacial abnormalities...
  5. ncbi Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
    Yoshihiro Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 130:5269-80. 2003
    Cleft palate and skull malformations represent some of the most frequent congenital birth defects in the human population...
  6. doi Biological mechanisms in palatogenesis and cleft palate
    L Meng
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Dent Res 88:22-33. 2009
    Clefts of the palate are common birth defects requiring extensive treatment. They appear to be caused by multiple genetic and environmental factors during palatogenesis...
  7. ncbi Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation
    Giovanni Levi
    Evolution des Regulations Endocriniennes, CNRS UMR5166, Museum national d histoire naturelle, Paris, France
    Mech Dev 123:3-16. 2006
    ..and middle ear), synergistically (deposition of bone tissue) or converging on the same morphogenetic process (palate growth and closure)...
  8. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct from isolated cleft secondary palate (CP)...
  9. pmc Mesenchymal cell remodeling during mouse secondary palate reorientation
    Jiu Zhen Jin
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville, Louisville, Kentucky
    Dev Dyn 239:2110-7. 2010
    The formation of mammalian secondary palate requires a series of developmental events such as growth, elevation, and fusion...
  10. ncbi Pathogenesis of cleft palate in TGF-beta3 knockout mice
    Y Taya
    Division of Cells, Immunology and Development, School of Biological Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Development 126:3869-79. 1999
    We previously reported that mutation of the transforming growth factor-beta3 (TGF-beta3) gene caused cleft palate in homozygous null (-/-) mice...
  11. pmc Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate
    Alison K Snyder-Warwick
    Division of Plastic Surgery, Departments of Developmental Biology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:2515-20. 2010
    Cleft palate is a common birth defect in humans and is a common phenotype associated with syndromic mutations in fibroblast growth factor receptor 2 (Fgfr2)...
  12. pmc Cleft palate: players, pathways, and pursuits
    Jeffrey C Murray
    Department of Pediatrics and Craniofacial Anomalies Research Center, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 113:1676-8. 2004
    Cleft lip and palate is a common human birth defect, and its causes are being dissected through studies of human populations and through the use of animal models...
  13. pmc Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 136:1387-96. 2009
    The mammalian secondary palate arises by outgrowth from the oral side of the paired maxillary processes flanking the primitive oral cavity...
  14. pmc TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    J Cell Sci 120:1646-53. 2007
    Dissociation of medial-edge epithelium (MEE) during palate development is essential for mediating correct craniofacial morphogenesis...
  15. ncbi A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Genet 36:1111-6. 2004
    ..perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos...
  16. pmc Epithelial-specific requirement of FGFR2 signaling during tooth and palate development
    Ryoichi Hosokawa
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Exp Zool B Mol Dev Evol 312:343-50. 2009
    ..K14-Cre;Fgfr2(fl/fl) mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of ..
  17. ncbi Multiple functions of Snail family genes during palate development in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 134:1789-97. 2007
    b>Palate development requires precise regulation of gene expression changes, morphogenetic movements and alterations in cell physiology. Defects in any of these processes can result in cleft palate, a common human birth defect...
  18. pmc Histomorphological study of palatal shelf elevation during murine secondary palate formation
    Kai Yu
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    Dev Dyn 240:1737-44. 2011
    During mammalian secondary palate development, the palatal shelves undergo dramatic morphological changes to elevate from a vertical to a horizontal plane in the oral-nasal cavity. We found that E14...
  19. ncbi EphB2 and EphB3 forward signalling are required for palate development
    Michael Risley
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
    Mech Dev 126:230-9. 2009
    ..Previous work had shown that the loss of ephrinB1 protein alone or compound loss of EphB2 and EphB3 leads to cleft palate. Because of the bidirectional signalling capability of these molecules, it was not clear whether forward or ..
  20. doi Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse
    Susann Zirzow
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 336:145-55. 2009
    Formation of the mammalian secondary palate is a highly regulated and complex process. Impairment of the underlying cellular and molecular programs often results in cleft palate, a common birth defect in mammals...
  21. ncbi Palatal shelf movement during palatogenesis: a fate map of the fetal mouse palate cultured in vitro
    Ming Jen Chou
    Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, 606 8501 Kyoto, Japan
    Anat Embryol (Berl) 208:19-25. 2004
    ..It seems that in the fetal mouse palate, the midpalate closes mainly by means of rotation and medial elongation of the shelf, whereas the anterior and ..
  22. pmc The mechanism of TGF-β signaling during palate development
    J Iwata
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Oral Dis 17:733-44. 2011
    Cleft palate, a malformation of the secondary palate development, is one of the most common human congenital birth defects...
  23. pmc The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 356:40-50. 2011
    Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction...
  24. ncbi Efficiency of a skeletonized distal jet appliance supported by miniscrew anchorage for noncompliance maxillary molar distalization
    Gero S M Kinzinger
    Department of Orthodontics, University of Saarland, Homburg Saar, Germany
    Am J Orthod Dentofacial Orthop 136:578-86. 2009
    ..The partial coverage of the palate, in particular, often results in compromised oral hygiene...
  25. ncbi Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung
    W M Weston
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:13698-703. 1999
    ..In situ hybridization analysis shows discrete regions of expression associated with the palate, nasal septum, and nasal conchae...
  26. pmc Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development
    Liam M Casey
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1830-44. 2006
    ..developing tongue and subsequently elevate and fuse with each other above the tongue to form the intact secondary palate. Pathological palate-mandible or palate-tongue fusions have been reported in humans and other mammals, but the ..
  27. ncbi Palate re-repair revisited
    Brian C Sommerlad
    St Andrew s Centre for Plastic Surgery, Broomfield Hospital, Essex, England, UK
    Cleft Palate Craniofac J 39:295-307. 2002
    To analyze the results of a consecutive series of palate re-repairs performed using the operating microscope and identify predictive factors for outcome.
  28. ncbi Death is the major fate of medial edge epithelial cells and the cause of basal lamina degradation during palatogenesis
    Rodrigo Cuervo
    Departament of Developmental Genetics and Molecular Physiology, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62210, Mexico
    Development 131:15-24. 2004
    During mammalian development, a pair of shelves fuses to form the secondary palate, a process that requires the adhesion of the medial edge epithelial tissue (MEE) of each shelf and the degeneration of the resulting medial epithelial seam ..
  29. pmc Regional regulation of palatal growth and patterning along the anterior-posterior axis in mice
    Sylvia A Hilliard
    Division of Developmental Biology, Department of Cell and Molecular Biology, and Center for Bioenvironmental Research, Tulane University, New Orleans 70118, USA
    J Anat 207:655-67. 2005
    Cleft palate is a congenital disorder arising from a failure in the multistep process of palate development. In its mildest form the cleft affects only the posterior soft palate...
  30. pmc PI-3 kinase activity is required for epithelial-mesenchymal transformation during palate fusion
    Pei Kang
    Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 225:316-21. 2002
    ..transformation (EMT) is the primary mechanism for the disappearance of medial edge epithelia (MEE) during palate fusion...
  31. pmc Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development
    Sophie Pantalacci
    Molecular Zoology, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
    BMC Dev Biol 8:116. 2008
    The development of the secondary palate has been a main topic in craniofacial research, as its failure results in cleft palate, one of the most common birth defects in human...
  32. doi Reduced tongue pressure against the hard palate on the paralyzed side during swallowing predicts Dysphagia in patients with acute stroke
    Nobuko Hirota
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
    Stroke 41:2982-4. 2010
    ..The present study investigated the relationship between tongue motor deficits and dysphagia in patients with acute stroke...
  33. pmc The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice
    Wenjin Liu
    Department of Biomedical Genetics and Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 135:3959-68. 2008
    The mammalian secondary palate exhibits morphological, pathological and molecular heterogeneity along the anteroposterior axis...
  34. ncbi [Differential expression of Bmp2, Bmp4 and Bmp3 in embryonic development of mouse anterior and posterior palate]
    Xu Guang Nie
    Sector of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Norway
    Chin Med J (Engl) 118:1710-6. 2005
    The palate is differently regulated and developed along the anterior-posterior axis. The Bmp signal pathway plays a crucial role in palatogenesis...
  35. pmc Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes
    Erwin Pauws
    UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH London, UK
    Hum Mol Genet 18:4171-9. 2009
    Craniofacial defects involving the lip and/or palate are among the most common human birth defects. X-linked cleft palate and ankyloglossia results from loss-of-function mutations in the gene encoding the T-box transcription factor TBX22...
  36. ncbi Face, palate, and craniofacial morphology in patients with a solitary median maxillary central incisor
    I Kjaer
    Department of Orthodontics, University of Copenhagen, Denmark
    Eur J Orthod 23:63-73. 2001
    ..It is therefore suggested that the SMMCI condition in future studies is classified according to clinical symptoms and craniofacial morphology...
  37. ncbi Mandibular growth retardation as a cause of cleft palate in mice homozygous for the chondrodysplasia gene
    R E Seegmiller
    J Embryol Exp Morphol 38:227-38. 1977
    ..in C57BL mice homozygous for the chondrodysplasia gene leads to deformity of limbs, ribs, trachea, mandible and palate. Since formation of the secondary palate depends upon coordinated development of several craniofacial structures, ..
  38. ncbi Alteration in the expression of bone morphogenetic protein-2,3,4,5 mRNA during pathogenesis of cleft palate in BALB/c mice
    H Lu
    Department of Oral Pathology, Stomatological College, Xi an, People s Republic of China
    Arch Oral Biol 45:133-40. 2000
    To identify the function of these bone morphogenetic proteins (BMP) during pathogenesis of cleft palate, an experimental model was established in BALB/c mice. Cleft palate was induced by exposure to retinoic acid on embryonic day (E)12...
  39. ncbi Occurrence and temporal variation in matrix metalloproteinases and their inhibitors during murine secondary palatal morphogenesis
    J Morris-Wiman
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, USA
    J Craniofac Genet Dev Biol 19:201-12. 1999
    Extracellular matrix (ECM) molecules are known to play a pivotal role in morphogenesis of the secondary palate, and changes in their composition and distribution, not attributable to changes in synthesis, are known to occur during ..
  40. pmc Applied anatomic site study of palatal anchorage implants using cone beam computed tomography
    Ren fa Lai
    Clinic of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China
    Int J Oral Sci 2:98-104. 2010
    ..The purpose of this study was to conduct quantitative research on bone height and bone mineral density of palatal implant sites for implantation, and to provide reference sites for safe and stable palatal implants...
  41. pmc Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate
    Ian C Welsh
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 336:53-67. 2009
    ..We have identified a unique region of the secondary palate associated with the periodic formation of rugae during the rostral outgrowth of the face...
  42. doi Spectrum of indications for palatal implants in treatment concepts involving immediate and conventional loading
    Britta A Jung
    Department of Orthodontics, University Medical Center of Johannes Gutenberg University, Mainz, Germany
    J Orofac Orthop 71:273-80. 2010
    ..To analyze the spectrum of indications for second-generation palatal implants in relation to two different loading concepts in a prospective, multicenter, randomized controlled trial (RCT)...
  43. pmc Mechanisms of transforming growth factor β induced cell cycle arrest in palate development
    Tatiana Iordanskaia
    Department of Oral Biology, College of Dentistry, The University of Nebraska Medical Center, Lincoln, Nebraska 68512, USA
    J Cell Physiol 226:1415-24. 2011
    Immaculate and complete palatal seam disintegration, which takes place at the last phase of palate development, is essential for normal palate development...
  44. ncbi Vanilloid receptor expression in the rat tongue and palate
    M A Kido
    Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    J Dent Res 82:393-7. 2003
    ..Immunohistochemistry revealed that the taste papillae in the tongue and palate are richly innervated by VR1-immunoreactive nerve fibers...
  45. pmc Palate morphogenesis: current understanding and future directions
    Robert M Greene
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, ULSD, Louisville, Kentucky 40292, USA
    Birth Defects Res C Embryo Today 90:133-54. 2010
    ..The secondary palate has provided an excellent paradigm that has enabled examination of a wide variety of developmental processes...
  46. ncbi Palatal fusion - where do the midline cells go? A review on cleft palate, a major human birth defect
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Mail Stop 35, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Acta Histochem 109:1-14. 2007
    Formation of the palate, the organ that separates the oral cavity from the nasal cavity, is a developmental process characteristic to embryos of higher vertebrates. Failure in this process results in palatal cleft...
  47. pmc Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice
    Jun Han
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 136:4225-33. 2009
    Cleft palate represents one of the most common congenital birth defects in human...
  48. ncbi Quantitative investigation of palatal bone depth and cortical bone thickness for mini-implant placement in adults
    Sebastian Baumgaertel
    Department of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Orthod Dentofacial Orthop 136:104-8. 2009
    ..The purpose of this study was to investigate both variables in the palate quantitatively to aid clinicians in planning successful mini-implant placements.
  49. ncbi Hoxa2 plays a direct role in murine palate development
    Tara M Smith
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Dev Dyn 238:2364-73. 2009
    The cleft palate exhibited by Hoxa2 null murine embryos has been described as being secondary to abnormalities of tongue musculature, and Hoxa2 was presumed to not play a direct role in palate development...
  50. pmc Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
    Huimin Yu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA
    Development 137:3707-17. 2010
    ..is a recurrent theme in mammalian embryology, and this process plays an integral role in the development of the palate, ventricular septum, neural tube, urethra, diaphragm and eye...
  51. ncbi Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair
    Nina Dathan
    Centro di Studi di Biocristallografia del CNR, Via Mezzocannone, Naples, Italy
    Dev Dyn 224:450-6. 2002
    ..Titf2 null mice exhibit cleft palate and either a sublingual or completely absent thyroid gland...
  52. doi Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
    Jong Min Lee
    Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University, Seoul, Republic of Korea
    Dev Biol 314:341-50. 2008
    Various cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development...
  53. ncbi Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)
    A Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, Goldensen Bldg, Room 342, Boston, MA 02115, USA
    Arch Oral Biol 49:675-89. 2004
    Formation of the medial edge epithelial (MEE) seam by fusing the palatal shelves is a crucial step of palate development. The opposing shelves adhere to each other at first by adherens junctions, then by desmosomes in the MEE...
  54. pmc Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation
    D Orioli
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 15:6035-49. 1996
    ..either Sek4 or Nuk are viable, most sek4/nuk1 double mutants die immediately after birth primarily due to a cleft palate. These results demonstrate essential and cooperative functions for Sek4 and Nuk in establishing axon pathways in ..
  55. pmc Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants
    Liang Tung Yang
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Dev Biol 312:384-95. 2007
    ..is strongly expressed in the prefusion palatal epithelium, and mice lacking Tgfb3 display a cleft of the secondary palate. To test whether the effect of TGF-beta3 in palatogenesis is isoform-specific in vivo, we generated a knockin ..
  56. ncbi Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion
    C L Brunet
    Division of Cells, Immunology and Development, School of Biological Sciences, University of Manchester, United Kingdom
    Int J Dev Biol 39:345-55. 1995
    ..Prevention of mature TGF-beta 3 activity during a specific time window of development in palate organ cultures, either by antisense oligodeoxynucleotides or neutralizing antibody, resulted in failure of palate ..
  57. pmc Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene
    G Caruana
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Mol Cell Biol 21:1475-83. 2001
    ..exhibit growth retardation in utero, have hypoplasia of the premaxilla and mandible, have a cleft secondary palate, and die perinatally...
  58. doi MiR-200b is involved in Tgf-β signaling to regulate mammalian palate development
    Jeong Oh Shin
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei University, 50 Yonsei ro, Seodaemoon Gu, Seoul 120 752, Korea
    Histochem Cell Biol 137:67-78. 2012
    ..key mediators of the transforming growth factor beta (Tgf-β) pathway, play a crucial role in the regulation of palate development...
  59. doi Anatomical study of the greater palatine artery and related structures of the palatal vault: considerations for palate as the subepithelial connective tissue graft donor site
    Sebastian Krystian Klosek
    Department of Periodontology and Oral Mucosal Diseases, Medical University of Lodz, 92 216, Lodz, Poland
    Surg Radiol Anat 31:245-50. 2009
    b>Palate is considered as a tissue graft donor site for dental surgical procedures...
  60. ncbi Occlusal relationship in patients with bilateral cleft lip and palate during the mixed dentition stage: does neonatal maxillary arch configuration predetermine outcome?
    Chad A Perlyn
    Cleft Palate and Craniofacial Deformities Institute, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cleft Palate Craniofac J 39:317-21. 2002
    To determine whether there is any correlation between initial maxillary arch dysmorphology patterns in complete bilateral cleft lip/palate (BCLP) and the subsequent occlusal relationship in early mixed dentition.
  61. pmc Gsk3β is required in the epithelium for palatal elevation in mice
    Fenglei He
    Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA
    Dev Dyn 239:3235-46. 2010
    ..Inactivation of Gsk3β in mice causes a cleft palate formation, suggesting an involvement of Wnt/β-catenin signaling during palatogenesis...
  62. ncbi Inhibition of human embryonic palatal mesenchymal cell cycle by secalonic acid D: a probable mechanism of its cleft palate induction
    V C Dhulipala
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Orthod Craniofac Res 7:227-36. 2004
    To assess the mechanism(s) of cleft palate induction by secalonic acid D (SAD) in human embryonic palatal mesenchymal (HEPM) cells and compare them with those evaluated in the murine embryonic palate.
  63. doi Diphenylhydantoin plays a role in gene expression related to cytoskeleton and protein adhesion in human normal palate fibroblasts
    Furio Pezzetti
    Histology, Embryology and Applied Biology Department, University of Bologna, Bologna, Italy
    Pathology 41:261-8. 2009
    Morphogenetic processes during palate development are related to extracellular matrix composition. The cell-extracellular matrix relation plays a role in cell activity and in gene expression...
  64. doi Clinical images: perforation of the nasal septum and palate due to Wegener's granulomatosis
    Timucin Kasifoglu
    Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey
    Arthritis Rheum 58:2564. 2008
  65. ncbi Mechanism of secalonic acid D-induced inhibition of transcription factor binding to cyclic AMP response element in the developing murine palate
    Umesh M Hanumegowda
    Department of Veterinary Biomedical Sciences, University of Missouri, W148 Vet Med Bldg, 1600 E Rollins, Columbia, Missouri 65211, USA
    Toxicol Sci 70:55-62. 2002
    ..Secalonic acid D (SAD), a mycotoxin causing cleft palate (CP), induces phosphorylation of palatal CREB in vivo...
  66. ncbi A blinded randomized controlled trial comparing lignocaine and placebo administration to the palate for removal of maxillary third molars
    M E Badcock
    School of Dental Science, University of Melbourne, 720 Swanston Street, Parkville, VIC 3010, Australia Private practice, Melbourne, Australia
    Int J Oral Maxillofac Surg 36:1177-82. 2007
    ..2 mL of lignocaine without vasoconstrictor was administered to one side of the palate and the same amount of normal saline administered to the other side...
  67. pmc ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
    R Shalom-Feuerstein
    INSERM U898, University of Nice, 28 Avenue Valombrose, Nice, France
    Cell Death Differ 18:887-96. 2011
    ..These data highlight the earliest recognized action of ΔNp63 in the induction epidermal morphogenesis at E11.5. In the absence of p63, a mesodermal program is activated while epidermal morphogenesis does not initiate...
  68. ncbi Histopathological findings of cleft palate in rat embryos induced by triamcinolone acetonide
    Satoshi Furukawa
    Biological Research Laboratories, Nissan Chemical Industries, Ltd, Minamisaitama, Saitama, Japan
    J Vet Med Sci 66:397-402. 2004
    Triamcinolone acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice...
  69. doi Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate
    Luca Scapoli
    Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, University of Bologna, Via Belmeloro, 8, 40126 Bologna, Italy
    Hum Mutat 31:794-800. 2010
    Nonsyndromic cleft lip with or without cleft palate (CL/P) affects approximately 1 in 1,000 births...
  70. pmc Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation
    Hiroyuki Enomoto
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Development 137:4029-38. 2010
    ..overlap of Adamts9 with Adamts20 was identified using Adamts9(+/-);bt/bt mice, which have a fully penetrant cleft palate. Palate closure was delayed, although eventually completed, in both Adamts9(+/-);bt/+ and bt/bt mice, ..
  71. ncbi Dental CT and orthodontic implants: imaging technique and assessment of available bone volume in the hard palate
    Andre Gahleitner
    Department of Radiology Osteology and MR, Medical School, University of Vienna, Wahringer Gurtel 18, A 1090, Austria
    Eur J Radiol 51:257-62. 2004
    ..The aim of this study was to determine whether dental CT could serve as a tool to locate the optimal size and position for orthodontic implant placement...
  72. doi The identification of children with cleft palate and sleep disordered breathing using a referral system
    J E MacLean
    Department of Respiratory Medicine, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    Pediatr Pulmonol 43:245-50. 2008
    Cleft palate is associated with an increased risk of sleep disordered breathing (SDB) but the magnitude of this risk and specific risk factors are unclear...
  73. ncbi A clinicopathologic study of malignant lymphomas of the nose, paranasal sinuses, and hard palate, including cases of lethal midline granuloma
    H Ratech
    James Irvine Center for the Study of Leukemia and Lymphoma, Division of Pathology, Duarte, California
    Cancer 64:2525-31. 1989
    Malignant lymphomas of the nose, paranasal sinuses, and hard palate show marked clinicopathologic, immunologic, and prognostic diversity...
  74. ncbi [Necrotizing sialometaplasia of the palate. Literature report of 3 new cases]
    A Schmidt Westhausen
    ,
    Dtsch Z Mund Kiefer Gesichtschir 15:30-4. 1991
    In this study 3 cases diagnosed as necrotizing sialometaplasia (NS) of the palate are described and discussed together with 106 other cases cited in the literature...
  75. ncbi Considerations for free-flap reconstruction of the hard palate
    N D Futran
    Department of Otolaryngology Head and Neck Surgery, University of Washington School of Medicine, Seattle 98195 6515, USA
    Arch Otolaryngol Head Neck Surg 125:665-9. 1999
    To evaluate the use of microvascular free-tissue transfers in the reconstruction of hard palate defects.
  76. pmc Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality
    M Parrish
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Cell Biol 24:7102-12. 2004
    ..the neural ectoderm and primitive streak and subsequently in the brain, peripheral nerves, spinal cord, limb buds, palate, heart, and otic vesicles. We have generated a targeted disruption of Sall3 in mice...
  77. ncbi Expression patterns of Hedgehog signalling pathway members during mouse palate development
    Ritva Rice
    Department of Craniofacial Development, King s College London, Floor 28 Guy s Tower, St Thomas Street, London SE1 9RT, UK
    Gene Expr Patterns 6:206-12. 2006
    ..No differences were found in the expression patterns of Hh pathway members along the anterior-posterior axis of the developing palate.
  78. ncbi Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate
    Xiao Mei Cui
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 278:193-202. 2005
    ..In the present study, the cleft palate phenotype in Tgf-beta3-/- mice was rescued by overexpression of a Smad2 transgene in Keratin 14-synthesizing MEE ..
  79. doi Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies
    Alexander W Wyatt
    Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hum Mutat 31:781-7. 2010
    ..eye anomalies and a range of systemic abnormalities, including developmental delay, deafness, scoliosis, and cleft palate. We determined that BMP7 is expressed in the developing eye, brain, and ear in human embryos in a manner ..
  80. doi The role of twist during palate development
    Wenli Yu
    Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 237:2716-25. 2008
    ..However, decreasing Twist with siRNA did not completely block palate fusion, indicating that the function of Twist may be duplicated by other transcription factors.
  81. ncbi Developmental dependency of Merkel endings on trks in the palate
    H Ichikawa
    Second Department of Oral Anatomy and Biodental Research Center, Okayama University Dental School, Okayama 700, Japan
    Brain Res Mol Brain Res 88:171-5. 2001
    Immunohistochemistry for protein gene product 9.5 was performed on Merkel cells in the palate of wildtype and knockout mice for trkA, trkB or trkC. In wildtype mice, numerous Merkel cells were observed at the top of anterior four rugae...
  82. ncbi Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure
    P J Miettinen
    Department of Growth and Development, University of California, San Francisco 94143 0452, USA
    Nat Genet 22:69-73. 1999
    Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,000 live births among ..
  83. ncbi Terminal differentiation of palatal medial edge epithelial cells in vitro is not necessarily dependent on palatal shelf contact and midline epithelial seam formation
    Toshiya Takigawa
    Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Dev Biol 48:307-17. 2004
    During fusion of the mammalian secondary palate, it has been suggested that palatal medial edge epithelial (MEE) cells disappear by means of apoptosis, epithelial-mesenchymal transformation (EMT) and epithelial cell migration...
  84. pmc Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development
    Xun Xu
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Cell 15:322-9. 2008
    ..In this study, we investigated the role of TGF-beta signaling in tooth and palate development and noted that conditional inactivation of Smad4 in oral epithelium results in much milder phenotypes ..
  85. pmc Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate
    Ritva Rice
    Departments of Craniofacial Development and Orthodontics, King s College, London, United Kingdom
    J Clin Invest 113:1692-700. 2004
    Classical research has suggested that early palate formation develops via epithelial-mesenchymal interactions, and in this study we reveal which signals control this process...
  86. ncbi Sensory nerve endings in the hard palate and papilla incisiva of the goat
    Z Halata
    Department of Functional Anatomy, Institute of Anatomy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Exp Brain Res 129:218-28. 1999
    The sensory innervation of the papilla incisiva in the hard palate of the domestic goat was studied with light and electron microscopy, supplemented by electrophysiological studies of free nerve endings. The goat lacks incisor teeth...
  87. pmc Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8
    Y Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:15002-6. 1999
    Formation of the mammalian secondary palate is a highly regulated and complex process whose impairment often results in cleft palate, a common birth defect in both humans and animals...
  88. ncbi Bulging medial edge epithelial cells and palatal fusion
    C Martinez-Alvarez
    Departamento de Ciencias Morfológicas I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    Int J Dev Biol 44:331-5. 2000
    ..and 16 most TGF-beta3 +/- and +/+ embryos showed total palatal fusion, whilst all TGF-beta3 null mutants had cleft palate: the middle third of the palatal shelves had adhered, leaving an anterior and posterior cleft...
  89. ncbi TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion
    Consuelo Tudela
    Departamento de Ciencias Morfológicas I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    Int J Dev Biol 46:333-6. 2002
    Transforming growth factor-beta3 (TGF-beta3) plays a critical role during palate development, since mutations of the TGF-beta3 gene give rise to cleft palate in both humans and mice...
  90. ncbi Unilateral complete cleft lip and palate repair using lip adhesion and passive alveolar molding appliance
    B Cho
    Department of Plastic and Reconstructive Surgery, Kyungpook National University Hospital, Samduk 2 ga, 50, Taegu, 700 421, Korea
    J Craniofac Surg 12:148-56. 2001
    To manage a unilateral complete cleft lip and palate, lip adhesion along with the positioning of a passive alveolar molding appliance was performed in infants at 3 to 6 weeks of age...
  91. ncbi Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome
    Alexandra S Knight
    Faculty of Life Sciences and School of Dentistry, University of Manchester, Manchester, United Kingdom
    Dev Dyn 235:1441-7. 2006
    Development of the lip and palate involves a complex series of events that are frequently disturbed resulting in the congenital anomalies cleft lip and cleft palate...
  92. doi The etiopathogenesis of cleft lip and cleft palate: usefulness and caveats of mouse models
    Amel Gritli-Linde
    Department of Oral Biochemistry, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Curr Top Dev Biol 84:37-138. 2008
    Cleft lip and cleft palate are frequent human congenital malformations with a complex multifactorial etiology...
  93. ncbi Response of Merkel cells in the palatal rugae to the continuous mechanical stimulation by palatal plate
    Ken Ishizaki
    Department of Complete Denture Prosthodontics, Tokyo Dental College, Chiba, Japan
    Somatosens Mot Res 23:63-72. 2006
    ..The palatal plate was made of adhesive resin and it was set on the palate of the animal. To exert a continuous pressure, a 0...
  94. ncbi Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced clefting
    M A Montenegro
    Department of Morphology, Biomedical Ciencies Institute, Faculty of Medicine, University of Chile
    J Craniofac Genet Dev Biol 20:137-43. 2000
    ..proteins, keratin and vimentin and, one adhesion molecule, cadherin in different stages of developing secondary palate in two strains of mice with different H-2 backgrounds was undertaken to investigate differences between a strain ..
  95. ncbi Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation
    Forugh Vaziri Sani
    Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Medicinaregatan 12F, SE 405 30 Goteborg, Sweden
    Dev Biol 285:490-5. 2005
    ..fusion of the palatine shelves is a crucial event, the failure of which results in the birth defect, cleft palate. The fate of the midline epithelial seam (MES), which develops transiently upon contact of the two palatine ..
  96. ncbi Regulation of Twist, Snail, and Id1 is conserved between the developing murine palate and tooth
    Ritva Rice
    Department of Craniofacial Development, King s College London, UK
    Dev Dyn 234:28-35. 2005
    The development of both the tooth and palate requires coordinated bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) signalling between epithelial and mesenchymal tissues...
  97. ncbi Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate
    Ling Yu
    Division of Developmental Biology, Department of Cell and Molecular Biology, and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 132:4397-406. 2005
    ..We report the restricted expression of Shox2 in the anterior domain of the secondary palate in mice and humans...
  98. ncbi Development of anterior gustatory epithelia in the palate and tongue requires epidermal growth factor receptor
    Hanshi Sun
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 3127 Natural Science Building, Ann Arbor, Michigan 48109 1048, USA
    Dev Biol 242:31-43. 2002
    ..bdnf(-/-) mice had similar reductions in the total number of taste buds on the anterior portions of the tongue and palate. Nonetheless, there were significant differences in their gustatory phenotypes...
  99. ncbi Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis
    Catherine Dode
    Institut Cochin, INSERM U567, Universite Rene Descartes, Paris, France
    Hum Mutat 28:97-8. 2007
    ..Moreover, the presence of cleft palate in a patient carrying the p.E324X change shows that FGFR1c is important for palate morphogenesis too.
  100. ncbi Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis
    Alexander Herr
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Dev Dyn 226:579-86. 2003
    ..Mutations in TBX22 have been reported in families with X-linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown...
  101. pmc TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
    Ali Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, B 1, Room 342, Boston, MA 02115 6092, USA
    J Cell Biol 163:1291-301. 2003
    ..We show with antisense beta-catenin oligonucleotides that up-regulated LEF1 is not activated by beta-catenin in palate EMT...

Research Grants88

  1. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2009
    ..The knock-out animals are perinatal lethal and have a pronounced cleft palate (B. Bjork, D. Beier et a/., in review)...
  2. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2010
    ..The knock-out animals are perinatal lethal and have a pronounced cleft palate (B. Bjork, D. Beier et a/., in review)...
  3. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..D. at the University of Rochester for work in understanding cleft lip and palate in the spontaneously-occurring Dancer mutant mouse...
  4. Middle Ear Pressure Regulation in Health and Disease
    William Doyle; Fiscal Year: 2006
    ..Subproject 3, "Middle Ear Pressure Disregulation in Cleft Palate Patients: Form-Function Correlates" develops a functional-anatomical description of middle ear pressure-regulation ..
  5. Middle Ear Pressure Regulation in Health and Disease
    William Doyle; Fiscal Year: 2009
    ..Subproject 3, "Middle Ear Pressure Disregulation in Cleft Palate Patients: Form-Function Correlates" develops a functional-anatomical description of middle ear pressure-regulation ..
  6. Middle Ear Pressure Regulation in Health and Disease
    William Doyle; Fiscal Year: 2007
    ..Subproject 3, "Middle Ear Pressure Disregulation in Cleft Palate Patients: Form-Function Correlates" develops a functional-anatomical description of middle ear pressure-regulation ..
  7. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2011
    ..tube function (ETF) and reducing the prevalences of otitis media with effusion (OME) and hearing loss in cleft palate (CP) patients without causing adverse events or having detrimental effects on the other functions affected by the ..
  8. Large Animal Model for Novel Autologous Treatments of Alveolar Clefts
    JOHN ANANDA VAN AALST; Fiscal Year: 2012
    ..consultations secondary to ultrasound diagnoses of craniofacial deformities--primarily clefts of the lip and palate. Because of these changing demographics and the candidate's interest in translational stem cell therapies, ..
  9. Quality of Life in Children with Cleft
    Hillary Broder; Fiscal Year: 2009
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
  10. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
  11. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
  12. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2002
    The etiology of craniofacial abnormalities is multi-factorial and defects such as cleft palate often occur in the absence of a known cause...
  13. A Developmental Craniofacial Atlas for the Zebrafish
    Charles B Kimmel; Fiscal Year: 2010
    ..model organism for understanding conserved features of development of the skull, and human disorders such as cleft palate. The atlas will provide a key resource for scientists wishing to discover how the complex anatomy of the zebrafish ..
  14. A Developmental Craniofacial Atlas for the Zebrafish
    Charles Kimmel; Fiscal Year: 2009
    ..model organism for understanding conserved features of development of the skull, and human disorders such as cleft palate. The atlas will provide a key resource for scientists wishing to discover how the complex anatomy of the zebrafish ..
  15. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2009
    ..a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL;cleft lip and palate, CLP;and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, Taiwan, and 2 sites in China)...
  16. EFFECTS OF RETINOIDS ON SQUAMOUS CELL CARCONOMAS
    Lorraine Gudas; Fiscal Year: 1992
    ..The normal human epithelial cell strains that will be analyzed include those from the soft palate, floor of mouth, buccal mucosa, ventral tongue, gingiva, hard palate, and facial epidermis...
  17. EFFECTS OF RETINOIDS ON SQUAMOUS CELL CARCONOMAS
    Lorraine Gudas; Fiscal Year: 1993
    ..The normal human epithelial cell strains that will be analyzed include those from the soft palate, floor of mouth, buccal mucosa, ventral tongue, gingiva, hard palate, and facial epidermis...
  18. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri H Beaty; Fiscal Year: 2010
    ..a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL;cleft lip and palate, CLP;and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, Taiwan, and 2 sites in China)...
  19. The role of the primitive choana in amniote craniofacial morphogenesis
    John Abramyan; Fiscal Year: 2012
    ..emphasis on identifying putative influences on other key elements of the embryonic oral cavity such as secondary palate formation...
  20. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..cause of genetic and developmental disorders, including mental retardation, autism, schizophrenia, epilepsy, cleft palate and many others...
  21. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    Thomas Glover; Fiscal Year: 2009
    ..cause of genetic and developmental disorders, including mental retardation, autism, schizophrenia, epilepsy, cleft palate and many others...
  22. CLONING OF THE Hol MUTATION
    Licia Selleri; Fiscal Year: 2009
    ..Also, their palate is cleft and the basisphenoid is fused to the basioccipital bone...
  23. CLONING OF THE Hol MUTATION
    Licia Selleri; Fiscal Year: 2009
    ..Also, their palate is cleft and the basisphenoid is fused to the basioccipital bone...
  24. Ribosomal Protein Gene Silencing in Neural Crest Stem Cells
    JOHNSON MING YU LIU; Fiscal Year: 2010
    ..of DBA have been linked to mutations in genes encoding ribosomal proteins, however, orofacial anomalies (cleft palate) were found only in patients with RPL5 mutations...
  25. Ribosomal Protein Gene Silencing in Neural Crest Stem Cells
    Johnson Liu; Fiscal Year: 2009
    ..of DBA have been linked to mutations in genes encoding ribosomal proteins, however, orofacial anomalies (cleft palate) were found only in patients with RPL5 mutations...
  26. TRAINING IN CELLULAR AND MOLECULAR BIOLOGY
    Malcolm Snead; Fiscal Year: 1999
    ..offers a wide spectrum of scientific training for students, which includes studying the mechanisms of cleft palate formation, the regulation of gene expression in facial muscles, prokaryotic virulence factors, analysis of gene ..
  27. Aspects of Biotin Nutrition
    Donald M Mock; Fiscal Year: 2010
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeleton and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl-CoA carboxylase which leads in turn to ..
  28. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2009
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeleton and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl-CoA carboxylase which leads in turn to ..
  29. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2009
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeleton and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl-CoA carboxylase which leads in turn to ..
  30. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2011
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (..
  31. GUSTATORY CHEMOSENSITIVITY OF THE ORAL PALATE
    INGLIS MILLER; Fiscal Year: 1980
    ..Taste buds are present on the oral palates of humans and the human palate is as sensitive to chemical solutions as the tongue...
  32. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2002
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeletons and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl- CoA carboxylase which leads in turn to ..
  33. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2006
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeletons and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl- CoA carboxylase which leads in turn to ..
  34. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2005
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeletons and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl- CoA carboxylase which leads in turn to ..
  35. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2003
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeletons and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl- CoA carboxylase which leads in turn to ..
  36. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2004
    ..1, we will test the hypothesis that maternal biotin deficiency causes abnormal development of fetal skeletons and palate by causing deficient fetal activity of the biotin-dependent enzyme acetyl- CoA carboxylase which leads in turn to ..
  37. CLEFT LIP AND PALATE IN LOS ANGELES HISPANICS
    M Spence; Fiscal Year: 1990
    ..the etiology of facial clefts by analyzing family data for the Hispanic population treated by the Cleft Palate Service of Rancho Los Amigos Hospital, Los Angeles County, California...
  38. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2007
    Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  39. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  40. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
    Cleft palate is one of the most frequently occurring birth defects in the United States...
  41. Effects of oral clefts on birth outcomes and cleft risks due to maternal smoking
    GEORGE WEHBY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Cleft lip and/or palate (CL/P) is a common birth defect with a complex ideology and large health burden...
  42. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2003
    Non-syndromic clefts of the lip and/or palate are among the most common malformations of the head and neck...
  43. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2004
    Non-syndromic clefts of the lip and/or palate are among the most common malformations of the head and neck...
  44. GENETIC AND MOLECULAR ANALYSES OF MOUSE MUTATIONS
    MURRAY BRILLIANT; Fiscal Year: 1992
    ..However, several mutant alleles exhibit additional phenotypes, including sterility, cleft palate, and two distinct neurological disorders (jerky movement and tremors)...
  45. NASAL AIRWAY AND RESPIRATORY MODE IN CLEFT PALATE
    DONALD WARREN; Fiscal Year: 1990
    The broad long-term objectives of this project are to: 1) determine how cleft lip/palate and its management affect nasal airway patency and breathing behaviors and 2) assess the biological, morphological and behavioral consequences of ..
  46. WOUND HEALING AFTER FETAL CLEFT LIP REPAIR
    Leonard Kaban; Fiscal Year: 1990
    Although excellent esthetic and functional results can be achieved with post-natal cleft lip and palate repair, consecutive surgical procedures lead to scar formation and secondary midface growth retardation...
  47. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 1993
    ..cycle of this proposal the investigators applied these techniques to a common sentinel birth defect--cleft lip and palate. These studies allowed identification of the association of a candidate gene, transforming growth factor alpha (..
  48. DNA LINKAGE STUDY OF CLEFT LIP AND PALATE
    Jacqueline Hecht; Fiscal Year: 1991
    ..of this project is to delineate the molecular mechanisms of heritable nonsyndromic cleft lip with or without cleft palate (CLP)...
  49. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2001
    Oral clefts (including cleft lip, CL; cleft palate, CP; and cleft lip and palate, CLP) represent a complex and heterogeneous group of crainofacial defects that constitute a major public health burden due to their high prevalence...
  50. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2000
    Oral clefts (including cleft lip, CL; cleft palate, CP; and cleft lip and palate, CLP) represent a complex and heterogeneous group of crainofacial defects that constitute a major public health burden due to their high prevalence...
  51. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2002
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  52. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2000
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  53. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2001
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  54. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2004
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  55. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2004
    Clefts of the lip and/or palate are among the most common and easily diagnosed birth defects, and can provide a model for complex trait analysis...
  56. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2003
    Clefts of the lip and/or palate are among the most common and easily diagnosed birth defects, and can provide a model for complex trait analysis...
  57. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    Clefts of the lip and/or palate are among the most common and easily diagnosed birth defects, and can provide a model for complex trait analysis...
  58. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2003
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  59. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2005
    Clefts of the lip and/or palate are among the most common and easily diagnosed birth defects, and can provide a model for complex trait analysis...
  60. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2009
    There are hundreds of craniofacial diseases in humans and cleft palate is common among these. The goal of this proposal is to elucidate the signaling interactions and cellular behaviors underlying palatogenesis...
  61. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2009
    There are hundreds of craniofacial diseases in humans and cleft palate is common among these. The goal of this proposal is to elucidate the signaling interactions and cellular behaviors underlying palatogenesis...
  62. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2009
    There are hundreds of craniofacial diseases in humans and cleft palate is common among these. The goal of this proposal is to elucidate the signaling interactions and cellular behaviors underlying palatogenesis...
  63. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2012
    ..We hope we have established an environment in which students can explore paths to careers in dental/craniofacial research. ..
  64. Skin Regeneration: Cellular & Molecular Mechanisms
    HERMANN PETER LORENZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cleft lip and palate is a major health problem because of the functional defect produced...
  65. MRI Analyses of the Velopharyngeal Mechanism among Different Adult Populations
    JAMIE PERRY; Fiscal Year: 2009
    ..to that of normal anatomy, it is likely that they will develop hypernasal speech and would require secondary palate surgery...
  66. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2003
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  67. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2002
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  68. Skin Regeneration: Cellular & Molecular Mechanisms
    HERMANN LORENZ; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cleft lip and palate is a major health problem because of the functional defect produced...
  69. MRI Analyses of the Velopharyngeal Mechanism among Different Adult Populations
    Jamie L Perry; Fiscal Year: 2010
    ..to that of normal anatomy, it is likely that they will develop hypernasal speech and would require secondary palate surgery...
  70. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2001
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  71. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2004
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  72. Molecular and Genetic Regulation of Craniofacial Development
    Brian Black; Fiscal Year: 2009
    ..800 live births and is characterized by small lower jaw, improperly positioned tongue and posterior cleft of the palate, which can result in upper airway obstruction and feeding difficulties...
  73. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2005
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  74. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2005
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  75. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2006
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  76. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2003
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  77. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2002
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  78. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2001
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  79. An Exploratory Model of Early Speech Intervention for Children with Cleft Palate
    Nancy Scherer; Fiscal Year: 2009
    Young children with cleft lip and/or palate are at risk for speech and language delays associated with structural deficits despite early surgical repair...
  80. An Exploratory Model of Early Speech Intervention for Children with Cleft Palate
    Nancy J Scherer; Fiscal Year: 2010
    Young children with cleft lip and/or palate are at risk for speech and language delays associated with structural deficits despite early surgical repair...
  81. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2004
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  82. The Role of GSK-3beta in Palate Development and Fusion
    Michael Longaker; Fiscal Year: 2009
    ..Among them, cleft palate posed an annual "national bill" exceeding $100 million in 2004 in direct hospital costs alone and is highly ..