lip

Summary

Summary: Either of the two fleshy, full-blooded margins of the mouth.

Top Publications

  1. ncbi Viewing lip forms: cortical dynamics
    Nobuyuki Nishitani
    Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, P O BOX 2200, FIN 02015 HUT, Espoo, Finland
    Neuron 36:1211-20. 2002
  2. ncbi Morphological patterns of lip prints in Saudi Arabia at Almadinah Almonawarah province
    Magda Ahmed El Domiaty
    Anatomy, Taiba University, Almadinah Almonawarah, Saudi Arabia
    Forensic Sci Int 200:179.e1-9. 2010
  3. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
  4. ncbi Lip prints (cheiloscopy)
    B Sivapathasundharam
    Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College, Alpakkam Rd, Maduravoyal, Chennai 602102, India
    Indian J Dent Res 12:234-7. 2001
  5. ncbi The current status of lip prints and their use for identification
    J Ball
    Centre for Forensic Science, University of Western Australia, Crawley
    J Forensic Odontostomatol 20:43-6. 2002
  6. ncbi Functional MRI assessment of orofacial articulators: neural correlates of lip, jaw, larynx, and tongue movements
    Krystyna Grabski
    GIPSA lab, Département Parole and Cognition, UMR CNRS 5216, Grenoble Universités, France
    Hum Brain Mapp 33:2306-21. 2012
  7. ncbi On the origin of internal structure of word forms
    P F MacNeilage
    Department of Psychology, Department of Communication Sciences and Disorders, University of Texas, Austin, TX 78712, USA
    Science 288:527-31. 2000
  8. ncbi Attractiveness of variations in the smile arc and buccal corridor space as judged by orthodontists and laymen
    Sanjay Manhar Parekh
    Angle Orthod 76:557-63. 2006
  9. ncbi The insect upper lip (labrum) is a nonsegmental appendage-like structure
    Nico Posnien
    Department of Developmental Biology, Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Georg August University, 37077 Gottingen, Germany
    Evol Dev 11:480-8. 2009
  10. ncbi Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis
    Mitsushiro Nakatomi
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Dev Biol 340:438-49. 2010

Detail Information

Publications292 found, 100 shown here

  1. ncbi Viewing lip forms: cortical dynamics
    Nobuyuki Nishitani
    Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, P O BOX 2200, FIN 02015 HUT, Espoo, Finland
    Neuron 36:1211-20. 2002
    ..We followed, by magnetoencephalographic cortical dynamics, subjects who observed still pictures of lip forms, on-line imitated them, or made similar forms in a self-paced manner...
  2. ncbi Morphological patterns of lip prints in Saudi Arabia at Almadinah Almonawarah province
    Magda Ahmed El Domiaty
    Anatomy, Taiba University, Almadinah Almonawarah, Saudi Arabia
    Forensic Sci Int 200:179.e1-9. 2010
    In the past decades, lip-print studies (cheiloscopy) attracted the attention of many scientists as a new tool for human identification in both civil and criminal issues...
  3. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct from isolated cleft secondary palate (CP)...
  4. ncbi Lip prints (cheiloscopy)
    B Sivapathasundharam
    Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College, Alpakkam Rd, Maduravoyal, Chennai 602102, India
    Indian J Dent Res 12:234-7. 2001
    External surface of the lip has many elevations and depressions forming a characteristic pattern called lip prints, examination of which is referred to as cheiloscopy. This is unique for individuals like the finger prints...
  5. ncbi The current status of lip prints and their use for identification
    J Ball
    Centre for Forensic Science, University of Western Australia, Crawley
    J Forensic Odontostomatol 20:43-6. 2002
    The use of lip prints for human identification was first suggested in 1950 and research was carried out on lip prints in the 1960s and early 1970s, resuming in the last few years...
  6. ncbi Functional MRI assessment of orofacial articulators: neural correlates of lip, jaw, larynx, and tongue movements
    Krystyna Grabski
    GIPSA lab, Département Parole and Cognition, UMR CNRS 5216, Grenoble Universités, France
    Hum Brain Mapp 33:2306-21. 2012
    ..To determine cortical and subcortical regions associated with supralaryngeal motor control, participants produced lip, tongue and jaw movements while undergoing functional magnetic resonance imaging (fMRI)...
  7. ncbi On the origin of internal structure of word forms
    P F MacNeilage
    Department of Psychology, Department of Communication Sciences and Disorders, University of Texas, Austin, TX 78712, USA
    Science 288:527-31. 2000
    ..Three of the patterns involve intrasyllabic consonant-vowel (CV) co-occurrence: labial (lip) consonants with central vowels, coronal (tongue front) consonants with front vowels, and dorsal (tongue back) ..
  8. ncbi Attractiveness of variations in the smile arc and buccal corridor space as judged by orthodontists and laymen
    Sanjay Manhar Parekh
    Angle Orthod 76:557-63. 2006
    ..To evaluate changes in attractiveness on the basis of computerized variations of smile arcs and buccal corridors for male and female smiles judged by orthodontists and laypersons...
  9. ncbi The insect upper lip (labrum) is a nonsegmental appendage-like structure
    Nico Posnien
    Department of Developmental Biology, Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Georg August University, 37077 Gottingen, Germany
    Evol Dev 11:480-8. 2009
    The insect upper lip--the labrum--is a lobe-like structure anterior to the mouth opening. Whether the labrum represents a fused pair of segmental appendages or evolved independently is heavily debated...
  10. ncbi Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis
    Mitsushiro Nakatomi
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Dev Biol 340:438-49. 2010
    ..the Pax9 and Msx1 mutations and observed that double homozygous mutants exhibit an incompletely penetrant cleft lip phenotype...
  11. ncbi P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice
    Masafumi Yasuda
    Division of Pediatric Dentistry, Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College, Kanagawa, Japan
    Neurosci Lett 528:67-72. 2012
    ..mechanical sensitivity of the whisker pad skin following complete Freund's adjuvant (CFA) injection into the lower lip. Mice with local inflammation induced by CFA injection into the lower lip demonstrated significant mechanical ..
  12. ncbi Aesthetic outcome of cleft lip and palate treatment. Perceptions of patients, families, and health professionals compared to the general public
    Nikolaos Gkantidis
    Department of Orthodontics and Dentofacial Orthopedics Head Prof Dr C Katsaros, School of Dental Medicine, University of Bern, Switzerland Electronic address
    J Craniomaxillofac Surg 41:e105-10. 2013
    ..Head photos of 12 adult patients with treated unilateral cleft lip and palate were evaluated by laypeople and professionals...
  13. ncbi De novo interstitial deletion of 1q32.2-q32.3 including the entire IRF6 gene in a patient with oral cleft and other dysmorphic features
    I Salahshourifar
    Human Genome Center, Universiti Sains Malaysia, Kubang Kerian, Malaysia
    Cytogenet Genome Res 134:83-7. 2011
    ..The extent of the deletion and the genotype-phenotype correlation are 2 crucial issues...
  14. ncbi Phantom movements and pain. An fMRI study in upper limb amputees
    M Lotze
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Germany
    Brain 124:2268-77. 2001
    ..functional MRI, we investigated 14 upper limb amputees and seven healthy controls during the execution of hand and lip movements and imagined movements of the phantom limb or left hand...
  15. ncbi Investigation of lead contents in lipsticks by solid sampling high resolution continuum source electrothermal atomic absorption spectrometry
    Sema Gunduz
    Istanbul Technical University, Faculty of Science and Letters, Department of Chemistry, 34469 Maslak Istanbul, Turkey
    Regul Toxicol Pharmacol 65:34-7. 2013
    ..The lead in 25 lipstick samples with different properties were 0.11-4.48 ng mg(-1) which were not significantly different from those (<0.026-7.19 ng mg(-1)) reported by FDA for around 400 samples...
  16. ncbi A follow-up study of minimally invasive lip biopsy in the diagnosis of Sjögren's syndrome
    Heikki Teppo
    Department of Otorhinolaryngology, Kanta Hame Central Hospital, 13530 Hameenlinna, Finland
    Clin Rheumatol 26:1099-103. 2007
    ..aims of this study were to characterize a minimally invasive technique of minor salivary gland biopsy of the lower lip and to present a large patient material undergoing this procedure because of a suspicion of Sjögren's syndrome (SS)..
  17. ncbi Total lower lip reconstruction with a composite radial forearm-palmaris longus tendon flap: a clinical series
    Seng Feng Jeng
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Hsien, Taiwan
    Plast Reconstr Surg 113:19-23. 2004
    Large, full-thickness lip defects after head and neck surgery continue to be a challenge for reconstructive surgeons. The reconstructive aims are to restore the oral lining, the external cheek, oral competence, and function (i.e...
  18. ncbi Poor visualization during direct laryngoscopy and high upper lip bite test score are predictors of difficult intubation with the GlideScope videolaryngoscope
    Marie Helene Tremblay
    Department of Anesthesiology, CHUM, Hopital Notre Dame, 1560 Sherbrooke East, Montreal, Canada, H2L 4M1
    Anesth Analg 106:1495-500, table of contents. 2008
    ..We undertook this prospective study to identify patient characteristics associated with difficult GlideScope intubation...
  19. ncbi GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting
    Anna M W Taylor
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Pain 152:1502-10. 2011
    ..the rat, a purely sensory branch of the trigeminal nerve, resulted in prolonged mechanical allodynia in the lower lip skin persisting up to 4 months...
  20. pmc Concentrations and potential health risks of metals in lip products
    Sa Liu
    Environmental Health Sciences Division, School of Public Health, University of California, Berkeley, Berkeley, California 94720 7360, USA
    Environ Health Perspect 121:705-10. 2013
    Metal content in lip products has been an issue of concern.
  21. ncbi Mucocutaneous junction of eyelid and lip: a study of the transition zone using epithelial cell markers
    Andri K Riau
    Singapore Eye Research Institute, Singapore
    Curr Eye Res 33:912-22. 2008
    The expression of epithelial cell markers in the mouse eyelid and lip was investigated in order to understand the nature of the interactions of mucosal and skin epithelium as to how they form the mucocutaneous junction (MCJ).
  22. ncbi Nasolabial symmetry following Tennison-Randall lip repair: a three-dimensional approach in 10-year-old patients with unilateral clefts of lip, alveolus and palate
    Stefanie Bilwatsch
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Craniomaxillofac Surg 34:253-62. 2006
    To assess the degree of facial symmetry in patients suffering from unilateral cleft lip, alveolus and palate (UCLAP) by determining differences between the cleft and the non-cleft hemifaces from 3D surface data.
  23. pmc Roles of BMP signaling pathway in lip and palate development
    Carolina Parada
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Front Oral Biol 16:60-70. 2012
    Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are severe disruptions affecting orofacial structures...
  24. pmc Lateral fast muscle fibers originate from the posterior lip of the teleost dermomyotome
    P Steinbacher
    Division of Zoology and Functional Anatomy, Department of Organismic Biology, University of Salzburg, Salzburg, Austria
    Dev Dyn 237:3233-9. 2008
    ..that this occurs by lateral-to-medial immigration of myogenic cells de-epithelializing from the posterior DM lip. These cells then appear to stop proliferation and migrate anteriorly to finally differentiate into muscle fibres...
  25. ncbi A perceptual equivalent of the labial-coronal effect in the first year of life
    Thierry Nazzi
    Laboratoire Psychologie de la Perception, CNRS, Universite Paris Descartes, Paris, France
    J Acoust Soc Am 126:1440-6. 2009
    ..The present study thus establishes an early perceptual equivalent of the LC bias initially found at the onset of word production. Implications of this finding for an understanding of the perception-production relationship are discussed...
  26. ncbi Dynamic smile analysis: changes with age
    Shyam Desai
    Department of Craniofacial Sciences, Health Center, University of Connecticut, Farmington, CT 06030 1725, USA
    Am J Orthod Dentofacial Orthop 136:310.e1-10; discussion 310-1. 2009
    The objective of this study was to define age-related changes in the smile. The areas of interest were upper lip length at smile and repose, upper lip thickness at smile and repose, maxillary incisal display at smile, interlabial gap ..
  27. ncbi Infant orthopedics has no effect on maxillary arch dimensions in the deciduous dentition of children with complete unilateral cleft lip and palate (Dutchcleft)
    Catharina A M Bongaarts
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Center, 309 Tandheelkunde, 6500 HB Nijmegen, The Netherlands
    Cleft Palate Craniofac J 43:665-72. 2006
    Evaluation of the effect of infant orthopedics on maxillary arch dimensions in the deciduous dentition in patients with unilateral cleft lip and palate.
  28. ncbi Changes in nociceptive sensory innervation in the epidermis of the rat lower lip skin in a model of neuropathic pain
    C Grelik
    Department of Pharmacology and Therapeutics, 3655 Prom Sir William Osler, Montreal, Que, Canada H3G 1Y6
    Neurosci Lett 389:140-5. 2005
    ..In this paper, changes in the innervation patterns of epidermal sensory afferent fibres in the rat lower lip have been studied following bilateral chronic constriction injury (CCI) of the mental nerve-a purely sensory branch ..
  29. ncbi Free radial forearm flap lip reconstruction: a clinical series and case reports of technical refinements
    Mahendra Daya
    Department of Plastic and Reconstructive Surgery, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Ann Plast Surg 62:361-7. 2009
    b>Lip reconstruction is best suited to the dictum of replacement of like tissue with like. The use of the remaining lip in the use of the lip reconstruction becomes more difficult as the size of the defect increases...
  30. ncbi Observation-execution matching and action inhibition in human primary motor cortex during viewing of speech-related lip movements or listening to speech
    Takenobu Murakami
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Neuropsychologia 49:2045-54. 2011
    ..This theory predicts that observation of speech-related lip movements or even listening to speech would result in effector and task specific increase of the excitability of ..
  31. ncbi Lip and oral mucosal lesions in 100 renal transplant recipients
    A Tülin Güleç
    Department of Dermatology, Baskent University Faculty of Medicine, Ankara, Turkey
    J Am Acad Dermatol 62:96-101. 2010
    Renal transplant recipients (RTRs) appear to be more susceptible to the development of oral mucosal disease and lip cancer as a result of graft-preserving immunosuppressive therapy...
  32. ncbi Development and validation of a photonumeric grading scale for assessing lip volume and thickness
    A B Rossi
    Johnson and Johnson Consumer and Personal Products Worldwide, Skillman, NJ, USA
    J Eur Acad Dermatol Venereol 25:523-31. 2011
    Currently, there is the need of a validated grading scale for assessing lip volume/thickness.
  33. ncbi Soft tissue profile in Anatolian Turkish adults: Part I. Evaluation of horizontal lip position using different soft tissue analyses
    Elif F Erbay
    Faculty of Dentistry, Department of Orthodontics, University of Istanbul, Turkey
    Am J Orthod Dentofacial Orthop 121:57-64. 2002
    This study investigated cephalometrically the horizontal lip position of Anatolian Turkish adults using the soft tissue analyses of Steiner, Ricketts, Burstone, Sushner, Holdaway, and Merrifield...
  34. ncbi Current concepts in lip reconstruction
    George L Coppit
    Vanderbilt University Medical Center, Nashville, Tennesee, USA
    Curr Opin Otolaryngol Head Neck Surg 12:281-7. 2004
    ..The management of the resulting lip defect remains a significant reconstructive challenge, requiring meticulous preoperative planning and surgical ..
  35. ncbi The esthetics of the smile: a review of some recent studies
    J K Dong
    Department of Prosthodontics, Wonkwang University School of Dentistry, Iksan, South Korea
    Int J Prosthodont 12:9-19. 1999
    ..This article reviews recent research on the esthetics of the smile, covering the attractiveness of the smile, the effect of aging on the smile, oral condition and the smile, personality and smile, and smile exercises...
  36. ncbi Tooth fragment embedded in the lower lip after dental trauma: case reports
    Alessandro Costa Da Silva
    Private Practice, Santos city, Brazil
    Dent Traumatol 21:115-20. 2005
    ..This report describes two cases in which dental fragments were embedded in the lip soft tissue...
  37. ncbi Bonding of fractured permanent central incisor crown following radiographic localization of the tooth fragment in the lower lip: a case report
    Gabriela Ferrari da Silva Schwengber
    Pediatric Dentitry, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Dent Traumatol 26:434-7. 2010
    ..Radiographic examination revealed the fractured tooth fragment embedded in the lower lip. The fractured tooth, with incomplete root formation, was treated endodontically and received a temporary ..
  38. ncbi Lip height and lip width after extended Mohler unilateral cleft lip repair
    Court B Cutting
    Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY 10016, USA
    Plast Reconstr Surg 111:17-23; discussion 24-6. 2003
    The purpose of this study was to evaluate the symmetry in lip height and lip width after extended Mohler unilateral cleft lip repair, with long-term follow-up monitoring...
  39. ncbi The diagnostic value of the upper lip bite test combined with sternomental distance, thyromental distance, and interincisor distance for prediction of easy laryngoscopy and intubation: a prospective study
    Zahid Hussain Khan
    Department of Anesthesiology, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Anesth Analg 109:822-4. 2009
    Accuracy of upper lip bite test (ULBT) has been compared with the Mallampati classification...
  40. ncbi Predicting difficult laryngoscopy in acromegaly: a comparison of upper lip bite test with modified Mallampati classification
    Deepak Sharma
    Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA
    J Neurosurg Anesthesiol 22:138-43. 2010
    Upper lip bite test (ULBT) is a simple test for predicting difficult intubation. However, it has not been evaluated in acromegalic patients...
  41. ncbi A comparison of the upper lip bite test (a simple new technique) with modified Mallampati classification in predicting difficulty in endotracheal intubation: a prospective blinded study
    Zahid Hussain Khan
    Department of Anesthesiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Anesth Analg 96:595-9, table of contents. 2003
    ..the following assessments: 1) oropharyngeal class according to the modified Mallampati criteria; 2) the new, upper lip bite criteria-class I = lower incisors can bite the upper lip above the vermilion line, class II = lower incisors ..
  42. ncbi Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
    Lanying Song
    Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA
    Development 136:3161-71. 2009
    Neither the mechanisms that govern lip morphogenesis nor the cause of cleft lip are well understood...
  43. pmc Development of the upper lip: morphogenetic and molecular mechanisms
    Rulang Jiang
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1152-66. 2006
    The vertebrate upper lip forms from initially freely projecting maxillary, medial nasal, and lateral nasal prominences at the rostral and lateral boundaries of the primitive oral cavity...
  44. ncbi Lip colour affects perceived sex typicality and attractiveness of human faces
    Ian D Stephen
    Department of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK
    Perception 39:1104-10. 2010
    ..Here, we investigate the effects of lip luminance and colour contrast on the attractiveness and sex typicality (masculinity/femininity) of human faces...
  45. ncbi Preliminary study of post mortem identification using lip prints
    Hajime Utsuno
    1st Department of Oral Anatomy, Matsumoto Dental University, 1780 Hirooka Gobara, Shiogiri, Nagano 399 0781, Japan
    Forensic Sci Int 149:129-32. 2005
    Identification using lip prints was first performed in the 1950s and was the subject of much research in the 1960s and 70s, leading to the acceptance of this technique as evidence in the criminal justice system...
  46. ncbi Luminous lip-prints as criminal evidence
    Ana Castelló
    Department of Legal Medicine, College of Medicine and Odontology, University of Valencia E G, 46010 Valencia, Spain
    Forensic Sci Int 155:185-7. 2005
    ..The study of latent lip prints (that is lip prints from protective lipstick, or permanent or long-lasting lipstick that do not leave any ..
  47. ncbi A validated lip fullness grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S161-6. 2008
    To develop the Lip Fullness Grading Scale for objective quantification of lip volume for a reliable assessment and to establish the reliability of this photonumeric scale for clinical research and practice.
  48. ncbi Nasolabial esthetics in children with complete unilateral cleft lip and palate after 1- versus 3-stage treatment protocols
    Piotr Fudalej
    Department of Pediatric Surgery, Institute of Mother and Child, Warsaw, Poland
    J Oral Maxillofac Surg 67:1661-6. 2009
    ..However, children with a repaired complete unilateral cleft lip and palate usually show some disfigurement of the nasolabial area...
  49. ncbi Combined effect of anterior malocclusion and inadequate lip coverage on dental trauma in primary teeth
    Gabriela C Bonini
    São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira 13, Ponte Preta, Campinas, Sao Paulo, Brazil
    Dent Traumatol 28:437-40. 2012
    ..to investigate whether the interaction of malocclusion (open bite or increased overjet) combined with inadequate lip coverage strengthens its association with traumatic dental injury (TDI) in the primary teeth of preschool children ..
  50. ncbi Surgical treatment of lip cancer: our experience with 106 cases
    Attilio Carlo Salgarelli
    Maxillo Facial Surgery Unit, Head and Neck Department, Modena and Reggio Emilia University, Modena, Italy
    J Oral Maxillofac Surg 67:840-5. 2009
    To report our experience with 106 cases of lip cancer.
  51. ncbi A cephalometric investigation of horizontal lip position in adult Nigerians
    Gerald Ikenna Isiekwe
    Department of Child Dental Health, College of Medicine, University of Lagos, Idi Araba, Lagos, Nigeria
    J Orthod 39:160-9. 2012
    The aims of this study were to (1) identify soft tissue cephalometric norms for horizontal lip position in an adult Nigerian population; (2) compare values for Nigerian males and females; and (3) compare Nigerian norms with established ..
  52. ncbi Reconstruction of the lower lip: Bernard technique and its variants
    Enrique Herrera
    Department of Dermatology, Virgen de la Victoria University Hospital, School of Medicine, Malaga, Spain
    Dermatol Surg 34:648-55. 2008
    Surgical treatment of epidermoid carcinoma of the lower lip occasionally involves resection of a large part of this anatomic area. Several techniques are available for its repair, including Bernard's technique...
  53. pmc Pressure from the lips and the tongue in children with class III malocclusion
    Wen hua Ruan
    Department of Stomatology, Children s Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    J Zhejiang Univ Sci B 8:296-301. 2007
    ..To discuss possible relationships between class III malocclusion and perioral forces by measuring the pressure from the lips and the tongue of children with class III malocclusion...
  54. pmc Computer-assisted lip diagnosis on Traditional Chinese Medicine using multi-class support vector machines
    Fufeng Li
    Laboratory of Information Access and Synthesis of TCM Four Diagnosis, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
    BMC Complement Altern Med 12:127. 2012
    In Traditional Chinese Medicine (TCM), the lip diagnosis is an important diagnostic method which has a long history and is applied widely...
  55. ncbi The staircase technique for treatment of cancer of the lower lip: a report of 36 cases
    A C Salgarelli
    Division of Maxillofacial Surgery, Azienda Ospedaliera Carlo Poma, Mantova, Italy
    J Oral Maxillofac Surg 59:399-402; discussion 403. 2001
    This article reports the authors' experience with treatment of lower lip cancer using the staircase technique.
  56. ncbi Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjögren's syndrome and healthy subjects
    A Larsson
    Department of Oral Pathology, Centre for Oral Health Sciences, Malmo University, Malmo, Sweden
    Scand J Immunol 61:98-107. 2005
    Serial sections of lower lip salivary gland (LSG) biopsies were examined by immunohistochemistry, using a battery of B- and partly T-related antibodies (CD5, CD20, CD21, CD27, CD38, CD45RO, CD79a, Bcl-2 and Bcl-6) in different groups of ..
  57. ncbi Statistical modelling of lip movement in the clinical context
    H Popat
    Applied Clinical Research and Public Health, School of Dentistry, Cardiff University, Cardiff, UK
    Orthod Craniofac Res 15:92-102. 2012
    To establish three-dimensional (3D) reference data on average lip movement in normal healthy subjects using statistical shape analysis techniques.
  58. ncbi Three-dimensional nasolabial displacement during movement in repaired cleft lip and palate patients
    C A Trotman
    Department of Orthodontics, University of North Carolina, Chapel Hill 27599 7450, USA
    Plast Reconstr Surg 105:1273-83. 2000
    ..movements, and (2) to compare the adjusted data among repaired unilateral (n = 4) and bilateral (n = 5) cleft lip and palate patients and noncleft control subjects (n = 50)...
  59. ncbi Recurrent double lip: literature review and report of a case
    Michael C Palma
    Department of Oral and Maxillofacial Surgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:e20-3. 2009
    Double lip is a rare oral anomaly caused by hyperplastic tissue of the labial mucosa that becomes more prominent with tension caused by smiling. This congenital or acquired abnormality can interfere with chewing, speaking, and esthetics...
  60. ncbi Sensory mapping of lip representation in brass musicians with embouchure dystonia
    Yoshihiro Hirata
    Institute of Biomagnetism and Biosignalanalysis, Munster University Hospital, Munster, Germany
    Neuroreport 15:815-8. 2004
    ..the patients' digit, and especially the thumb, representations were shifted in a lateral direction towards the lip representational zone. Patients' upper lips showed decreased sensitivity compared to their lower lips (p < 0.01)...
  61. pmc Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development
    Yong Ri Jin
    COBRE in Stem Cell and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME 04074, USA
    Development 139:1821-30. 2012
    ..of the lateral and medial nasal processes and of the maxillary process of the first branchial arch are integral to lip and primary palate development...
  62. ncbi Changes in the lip closing force of patients with class III malocclusion before and after orthognathic surgery
    K Ueki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Japan
    Int J Oral Maxillofac Surg 41:835-8. 2012
    The purpose of this study was to examine the changes in lip pressure before and after orthognathic surgery for skeletal class III patients...
  63. ncbi Identification of IRF6 gene variants in three families with Van der Woude syndrome
    Ene Choo Tan
    KK Research Centre, KK Women s and Children s Hospital, Singapore 229899, Singapore
    Int J Mol Med 21:747-51. 2008
    ..It is characterised by the presence of lip pits, cleft lip and/or cleft palate...
  64. ncbi Environmental dew point and skin and lip weathering
    C Devillers
    Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    J Eur Acad Dermatol Venereol 24:513-7. 2010
    ..aimed to assess the relationship between the environmental DP and the water-holding capacity of the skin and lower lip vermilion...
  65. ncbi Lip repositioning for reduction of excessive gingival display: a clinical report
    Ari Rosenblatt
    Int J Periodontics Restorative Dent 26:433-7. 2006
    ..This case report demonstrates the successful management of excessive gingival display with a lip-repositioning procedure...
  66. pmc A geometric morphometric approach to the analysis of lip shape during speech: development of a clinical outcome measure
    Hashmat Popat
    Applied Clinical Research and Public Health, School of Dentistry, Cardiff University, Cardiff, United Kingdom
    PLoS ONE 8:e57368. 2013
    Objective assessments of lip movement can be beneficial in many disciplines including visual speech recognition, for surgical outcome assessment in patients with cleft lip and for the rehabilitation of patients with facial nerve ..
  67. ncbi Evaluation of upper lip hypoesthesia with a trigeminal somatosensory-evoked potential following Le Fort I osteotomy in combination with mandibular osteotomy
    Koichiro Ueki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:169-74. 2007
    The purpose of this study was to objectively evaluate hypoesthesia of the upper lip following Le Fort I osteotomy in combination with mandibular osteotomy with trigeminal somatosensory evoked potential (TSEP).
  68. ncbi Neurosensory alteration in the lower lip and chin area after orthognathic surgery: bilateral sagittal split osteotomy versus inverted L ramus osteotomy
    Akiko Kobayashi
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Oral Maxillofac Surg 64:778-84. 2006
    ..This study investigated neurosensory disturbances in patients after orthognathic surgery in relation to differences in mandibular splitting methods and degree of surgical skill...
  69. ncbi Expression and regulation of the LIM homeodomain gene L3/Lhx8 suggests a role in upper lip development of the chick embryo
    Masahide Inoue
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 634 8522, Kashihara Nara, Japan
    Anat Embryol (Berl) 211:247-53. 2006
    ..Our data suggest that the L3/Lhx8 gene contributes to epithelial mesenchymal interaction in facial morphogenesis and that Fgf-8b and TGF-beta3 were, at least in part, responsible for the Lhx expression in the maxillary process...
  70. pmc Effects of lip revision surgery in cleft lip/palate patients
    C A Trotman
    Department of Orthodontics, University of Maryland Dental School, 650 W Baltimore Street, Room 6408, Baltimore, MD 21201, USA
    J Dent Res 89:728-32. 2010
    The decision for lip revision surgery in patients with repaired cleft lip/palate is based on surgeons' subjective evaluation of lip disability. An objective evaluation would be highly beneficial for the assessment of surgical outcomes...
  71. ncbi Different lip asymmetry in adults who stutter: electromyographic evidence during speech and non-speech
    Ai Leen Choo
    University of IllinoisChampaign, IL, USA
    Folia Phoniatr Logop 62:143-7. 2010
    The present study examined whether abnormal cerebral control was evident in the lip movements of adult stutterers (AS) compared to non-stutterers (ANS), as demonstrated during speech and non-speech tasks...
  72. ncbi Association of lip pigmentation with smoking and gingival melanin pigmentation
    S Haresaku
    Department of Preventive and Public Health Dentistry, Fukuoka Dental College, Fukuoka, Japan
    Oral Dis 13:71-6. 2007
    We investigated the association of lip pigmentation with smoking and melanin pigmentation in the gingiva.
  73. ncbi Digital videographic measurement of tooth display and lip position in smiling and speech: reliability and clinical application
    Pieter A A M van der Geld
    Department of Orthodontics and Oral Biology and Cleft Palate Craniofacial Unit, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Orthod Dentofacial Orthop 131:301.e1-8. 2007
    Tooth display and lip position in smiling and speech are important esthetic aspects in orthodontics and dentofacial surgery...
  74. ncbi Mulliken method of bilateral cleft lip repair: anthropometric evaluation
    Seok Kwun Kim
    Department of Plastic and Reconstructive Surgery, Dong A University School of Medicine, Busan, Korea
    Plast Reconstr Surg 116:1243-51; discussion 1252-4. 2005
    Simultaneous surgical correction of bilateral cleft lip and nasal deformity is becoming more common. This is a major change from the conventional strategy of secondary nasal correction.
  75. ncbi Utility of lip biopsy in the diagnosis and treatment of Sjogren's syndrome
    Alexander J Langerman
    Department of Surgery, Section of Otolaryngology Head and Neck Surgery, University of Chicago, Chicago, Illinois 60637, USA
    Laryngoscope 117:1004-8. 2007
    ..In patients with a questionable diagnosis of SS but severe extraglandular symptoms, a lip biopsy is often performed to firmly establish the diagnosis of SS...
  76. ncbi Evaluation of different esthetic smile criteria
    Sulieman S Al-Johany
    Department of Prosthetic Dental Sciences, King Saud University, Riyadh, Saudi Arabia
    Int J Prosthodont 24:64-70. 2011
    ..The aim of this study was to evaluate the existence of different esthetic smile criteria as determined on the smiles of celebrities, which were considered by lay people to be beautiful...
  77. ncbi Total lower lip reconstruction with innervated muscle-bearing flaps: a modification of the Webster flap
    I Zilinsky
    Mohs Surgical Unit and Department of Plastic and Reconstructive Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Dermatol Surg 27:687-91. 2001
    Mohs surgery and other surgical techniques are used for the removal of squamous cell carcinoma of the lower lip and may leave a large defect in the vermilion and underlying tissue...
  78. ncbi Long-term stability of combined rapid palatal expansion-lip bumper therapy followed by full fixed appliances
    Tyler Ferris
    Am J Orthod Dentofacial Orthop 128:310-25. 2005
    The purpose of this study was to evaluate the long-term postretention stability of rapid palatal expansion-lip bumper therapy followed by full fixed appliances.
  79. ncbi An instrument for the non-invasive assessment of lip function during speech
    Kevin S Dawes
    Medical Electronics Research Group, Electronic Engineering Laboratory, University of Kent, Canterbury, Kent CT2 7NT, UK
    Med Eng Phys 27:523-35. 2005
    This paper describes the development of an instrument using infrared light as a non-invasive means of detecting lip opening, the extent of the opening and also the forward protrusion and backward movement of the lips during speech...
  80. ncbi Outcome of tongue-lip plication in patients with severe Pierre Robin sequence
    William Hoffman
    Department of Plastic Surgery, University of California at San Francisco, San Francisco, CA 94117, USA
    J Craniofac Surg 14:602-8. 2003
  81. ncbi Analysis of nasal and labial deformities in cleft lip, alveolus and palate patients by a new rating scale: preliminary report
    Y Anastassov
    Plastic and Craniofacial Unit, Medical Institute of Plovdiv, Bulgaria
    J Craniomaxillofac Surg 31:299-303. 2003
    In this study the nasal deformities in patients with cleft lip, alveolus and palate (CLAP) were analysed and the relevant role of the perinasal-perioral muscular balance, and the inborn dislocation of the alar cartilages is presented.
  82. ncbi Spontaneous eruption of an occult incisor fragment from the lip after eight months: report of a case
    Dinesh Rao
    Department of Pediatric Dentistry, Pacific Dental College and Hospital, Udaipur, Rajasthan, India
    J Clin Pediatr Dent 30:195-7. 2006
    ..They are often found embedded in the oral soft tissues, most commonly the lip. Early detection and complete removal of such fragments is critical in order to prevent infection and scarring...
  83. ncbi Lip muscle training in stroke patients with dysphagia
    Mary Hägg
    Speech and Swallowing Centre, Department of Otorhinolaryngology, Hudiksvall Hospital, Sweden
    Acta Otolaryngol 128:1027-33. 2008
    Training with an oral screen can improve lip force (LF) and swallowing capacity (SC) in stroke patients with oropharyngeal dysphagia, irrespective of the duration of pretreatment of dysphagia, and irrespective of the presence or absence ..
  84. ncbi Congenital lower lip pits (Van der Woude syndrome): presentation of 10 cases
    E Nagore
    Department of Dermatology, Hospital General Universitario, Valencia, Spain
    Pediatr Dermatol 15:443-5. 1998
    Congenital lower lip pits are a rare developmental malformation of the lower lip. Clinically they present as bilateral depressions in the vermilion zone of the lower lip...
  85. ncbi Movement disorder of the lower lip
    Marielle Wohlgemuth
    Mov Disord 20:1085-6. 2005
  86. ncbi Postoperative nasal forms after presurgical nasoalveolar molding followed by medial-upward advancement of nasolabial components with vestibular expansion for children with unilateral complete cleft lip and palate
    Norifumi Nakamura
    Department of Oral and Maxillofacial Surgery, Field of Maxillofacial Rehabilitation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Oral Maxillofac Surg 67:2222-31. 2009
    The management for primary unilateral cleft lip nose deformities has not yet been established...
  87. ncbi Outcomes of mini-hypoglossal nerve transfer and direct muscle neurotization for restoration of lower lip function in facial palsy
    Julia K Terzis
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Microsurgical Research Center, Eastern Virginia Medical School, Norfolk, VA 23501, USA
    Plast Reconstr Surg 124:1891-904. 2009
    Most reconstructions for lower lip palsy focus on paralyzing the contralateral normal lip or providing static support on the affected side...
  88. ncbi The morphological features and developmental changes of the philtral dimple: a guide to surgical intervention in cases of cleft lip
    Naoko Kishi
    First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Osaka, Japan
    J Craniomaxillofac Surg 40:215-22. 2012
    This study was undertaken to analyse in detail the morphological features of the philtral dimple and the developmental changes of philtral morphology, including a comparison with patients with a cleft lip.
  89. ncbi Trigeminal nerve-mediated reflex arterial blood pressure decrease and vasodilatation in lower lip of the rabbit
    Makoto Yasuda
    Dento oral Anesthesiology, Tohoku University Graduate School of Dentistry, 980 8575 Sendai, Japan
    Brain Res 987:59-66. 2003
    We measured the effects of electrical stimulation of the central cut end of the lingual nerve on lower lip blood flow (LBF) and on arterial blood pressure in urethane-anesthetized, artificially ventilated, cervically vagosympathectomized ..
  90. ncbi Functional lower lip reconstruction with bilateral cheek advancement flaps: revisitation of Webster method with a minor modification in the technique
    Gottfried Wechselberger
    Department of Plastic and Reconstructive Surgery, Leopold Franzens University of Innsbrug, Innsbruck, Austria
    Aesthetic Plast Surg 26:423-8. 2002
    Major defects of the lower lip have been repaired in many ways. Of these, some employed flaps from the chin, cheek or upper lip. Some of these procedures employed flaps without regard for the facial grooves or landmarks...
  91. ncbi Rejuvenation of the aging lip with an injectable acellular dermal graft (Cymetra)
    Anthony P Sclafani
    Division of Facial Plastic Surgery, Department of Otolaryngology Head and Neck Surgery, The New York Eye and Ear Infirmary, 310 E 14th St, North Building, Sixth Floor, New York, NY 10003, USA
    Arch Facial Plast Surg 4:252-7. 2002
    To evaluate the effects of Cymetra (micronized AlloDerm tissue) in rejuvenating the aging and atrophic lip.
  92. ncbi Change of lip-line cant after 1-jaw orthognathic surgery in patients with mandibular asymmetry
    Hyeon Shik Hwang
    Department of Orthodontics, 2nd Stage of Brain Korea 21, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju, Korea
    Am J Orthod Dentofacial Orthop 136:564-9. 2009
    The purpose of this study was to investigate the change of lip-line cant (LLC) after 1-jaw orthognathic surgery in mandibular asymmetry patients.
  93. ncbi Change in upper lip height and nostril sill after alveolar bone grafting in unilateral cleft lip alveolus patients
    Suk Wha Kim
    Department of Plastic and Reconstructive Surgery, Institute of Dermatological Science, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Plast Reconstr Aesthet Surg 65:558-63. 2012
    ..However, there are no studies which include details of changes to the upper lip with appropriate measurements...
  94. ncbi A simple and quantitative method for three-dimensional measurement of normal smiles
    Young Seok Kang
    Department of Plastic and Reconstructive Surgery, College of Medicine, Pusan National University, Busan 602 739, Korea
    Ann Plast Surg 54:379-83. 2005
    ..Our work may offer a simple and quantitative method for measuring the smile and accurate guidance for reconstructive surgery...
  95. ncbi Comparison of filling agents for lip augmentation
    Deborah S Sarnoff
    Department of Dermatology, New York University School of Medicine, New York, NY, USA
    Aesthet Surg J 28:556-63. 2008
    ..agents currently available that can be used to augment the lips, correct perioral rhytides, and enhance overall lip appearance...
  96. ncbi The effect of lip strengthening exercises in children and adolescents with myotonic dystrophy type 1
    Lotta Sjögreen
    Division of Speech and Language Pathology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mun H Center Orofacial Resource Centre for Rare Diseases, Gothenburg, Sweden
    Int J Pediatr Otorhinolaryngol 74:1126-34. 2010
    ..Most children and adolescents with DM1 have weak lips and impaired lip function...
  97. ncbi Occlusal relationship in patients with bilateral cleft lip and palate during the mixed dentition stage: does neonatal maxillary arch configuration predetermine outcome?
    Chad A Perlyn
    Cleft Palate and Craniofacial Deformities Institute, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cleft Palate Craniofac J 39:317-21. 2002
    To determine whether there is any correlation between initial maxillary arch dysmorphology patterns in complete bilateral cleft lip/palate (BCLP) and the subsequent occlusal relationship in early mixed dentition.
  98. ncbi Nonanimal stabilized hyaluronic acid for lip augmentation and facial rhytid ablation
    Stephen Bosniak
    Manhattan Eye, Ear, and Throat Hospital, New York, NY, USA
    Arch Facial Plast Surg 6:379-83. 2004
    ..To evaluate the effectiveness of nonanimal stabilized hyaluronic acid as an injectable filling agent...
  99. ncbi [Lenghtening temporalis myoplasty V.2. and lip reanimation]
    D Labbe
    4, place Fontette, 14000 Caen, France
    Ann Chir Plast Esthet 54:571-6. 2009
    ..The surgery is easier, quicker and the postoperative care are simplified. The coronoid process is osteotomised throught the nasolabial approach avoiding the zygoma's osteotomy...
  100. ncbi Proportions in the upper lip-lower lip-chin area of the lower face as determined by photogrammetric method
    Sandra Anic-Milosevic
    Department of Orthodontics, School of Dental Medicine, University of Zagreb, Croatia
    J Craniomaxillofac Surg 38:90-5. 2010
    ..and seven indices used to determine the relationships between measurements of the lower third of the face, lower lip, chin and upper lip. Almost all the vertical profile measurements were greater in males than in females...
  101. ncbi Tooth display and lip position during spontaneous and posed smiling in adults
    Pieter Van der Geld
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Odontol Scand 66:207-13. 2008
    To analyze differences in tooth display, lip-line height, and smile width between the posed smiling record, traditionally produced for orthodontic diagnosis, and the spontaneous (Duchenne) smile of joy.

Research Grants71

  1. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Over 70% of all birth defects in humans affect the head and face. Cleft lip with or without cleft palate (CL[unreadable]P) is one of the most common of these defects, occurring in approximately 1 per ..
  2. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..D. at the University of Rochester for work in understanding cleft lip and palate in the spontaneously-occurring Dancer mutant mouse...
  3. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    ..b>Lip biopsy samples will be analyzed for structure of tertiary lymphoid organs and their cellular content...
  4. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..D. at the University of Rochester for work in understanding cleft lip and palate in the spontaneously-occurring Dancer mutant mouse...
  5. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah C Kinney; Fiscal Year: 2010
    ..SIDS, or a subset of SIDS, is due to a developmental abnormality in a ventral medullary network composed of rhombic lip-derived, serotonergic neurons, and this abnormality results in a failure of protective responses to life-..
  6. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri H Beaty; Fiscal Year: 2013
    ..successfully conducted a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL;cleft lip and palate, CLP;and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, Taiwan, ..
  7. Genetic Risk for Orofacial Clefts in the Folate/Homocysteine Pathway
    NICHOLAS MARINI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Orofacial clefts, specifically cleft lip and cleft palate, are common and costly congenital anomalies whose etiologies remain largely unknown...
  8. Targeting aberrant epigenetics by nanomedicine
    Shujun Liu; Fiscal Year: 2013
    ..2. Determine the pharmacological activity of the combination of Lip-bortezomib with LPs-Sp1 siRNA or Lip-bortezomib with LPs-miR29b in AML cell lines and patient primary cells...
  9. Regulation of glucose homeostasis by C/EBPB
    Jacob E Friedman; Fiscal Year: 2010
    ..Aim 3 we will determine the metabolic consequences of over-expressing the activating (LAP) and liver inhibiting (LIP) form of C/EBPb on lipogenesis and gluconeogenesis in-vivo...
  10. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2013
    ..but there are no funds to subphenotype beyond this year, We will do the 3D imaging, 00 ultrasounds, dental and lip exams on the lowa and Philippines populations that have been solely supported by this grant...
  11. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2010
    ..Understanding how neural crest cells develop is important because common birth defects such as cleft lip and palate are caused by abnormal development in this cell type.
  12. Regulation of orofacial ectodermal polarity by the CLP protein, IRF6
    EMILY YIN CHU; Fiscal Year: 2013
    ..by applicant): Interferon regulatory factor 6 (IRF6) variants are associated with common isolated forms of cleft lip with or without clefting of the palate (CLP), as well as with dominantly inherited forms of CLP...
  13. Regulation of Cell Growth by RNA Binding Proteins
    Nikolai A Timchenko; Fiscal Year: 2012
    ..5'region of C/EBP[unreadable] mRNA and increases translation of a dominant negative molecule C/EBP[unreadable]-LIP, which inhibits biological activities of full-length C/EBP proteins and promotes liver proliferation...
  14. The role of inflammatory cytokines in the regulation of hepatic insulin signaling
    Daniel Okin; Fiscal Year: 2013
    ..TNF? on [hepatocyte insulin-signaling and functional response including gluconeogenesis, glycogen synthesis, and lip genesis]...
  15. The role of dinitrosyliron complexes in cancer etiology
    Douglas D Thomas; Fiscal Year: 2013
    ..based on the discovery that when cancer cells are exposed to NO it reacts with free iron in the labile iron pool (LIP). This results in the quantitative conversion of this iron into paramagnetic dinitrosyliron complexes (DNIC)...
  16. Shared Decision Making In Pediatric Chronic Conditions: Biologics in IBD and JIA
    Ellen A Lipstein; Fiscal Year: 2013
    ..Additionally, the divisions of gastroenterology and rheumatology, where Dr. Lip- stein's research will be conducted and from which her co-mentors are drawn, are each leaders in their respec- ..
  17. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2013
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  18. DGAP: Developmental Genome Anatomy Project
    CYNTHIA CASSON MORTON; Fiscal Year: 2013
    ..These anomalies can include isolated defects ranging from cleft lip/palate, abdominal wall defects, limb defects, cardiac abnormalities or mental retardation, or they can occur as ..
  19. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..The surgical procedures will include cleft lip repair (if present) at 3-6 months of age, bilateral placement of a ventilation tube (VT) at 3-6 months of age, the ..
  20. Leica LMD 7000 Laser Capture Microdissection Microscope
    Siegfried Janz; Fiscal Year: 2013
    ..rates along individual chromosomes;Jeffery Murray and Martine Dunnwald perform genetic studies on cleft lip and palate formation;David Stolz and Aliye Uc examine organ damage in a newly developed pig model of human cystic ..
  21. Lipid storage and mobilization in M. tuberculosis as antilatency drugs targets
    PAPPACHAN KOLATTUKUDY KOLATTUKUDY; Fiscal Year: 2013
    ..To elucidate these steps we propose to: (1) Generate gene-disrupted mutants for tgs, fcr, fabp, fatp, cut and lip genes that may encode enzymes that could be involved in the storage and mobilization of lipids for successfully ..
  22. Large Animal Model for Novel Autologous Treatments of Alveolar Clefts
    JOHN ANANDA VAN AALST; Fiscal Year: 2013
    ..for prenatal consultations secondary to ultrasound diagnoses of craniofacial deformities--primarily clefts of the lip and palate...
  23. Targeting the DNA Damage Response for the Treatment of Herpes Simplex Labialis
    WILLIAM DONEGAN; Fiscal Year: 2013
    ..HSL refers to HSV-1 infection of the lip and mouth, and is the most common of these maladies...
  24. The role of MID1/MID2 in regulating epithelial adhesion
    CATHERINE KOTO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cleft lip with or without cleft plate (CLP) is a common birth defect with multifactorial etiologies...
  25. The North Carolina Cleft Outcomes Study
    Ronald P Strauss; Fiscal Year: 2013
    ..outcomes, academic achievement, timeliness and use of services (genetics services, speech and language, lip/palate repair and revision surgeries), expenditures, and use and costs of team care...
  26. MicroRNAs in cleft lip and palate
    JAMES FRANCIS MARTIN; Fiscal Year: 2013
    ..Our preliminary data indicate that miR17-92 mutant embryos have severe craniofacial phenotypes, including cleft lip and palate (CL/P) and mandibular hypoplasia, consistent with the hypothesis that miR17-92 is a Bmp-target in ..
  27. FASEB SRC on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lip
    Andrew S Greenberg; Fiscal Year: 2012
    ..Thus, a better understanding of lipid droplet formation, dynamics, and turnover will provide new information that may be used to impact the development of these disorders. ..
  28. Molecular characterization of novel loci for orofacial clefting using canine mode
    Danika L Bannasch; Fiscal Year: 2013
    ..They can occur as isolated cases of cleft palate (CPO), or cleft lip with or without cleft palate (CL/P), or in combination with other birth defects...
  29. CELLULAR SUBSTRATES OF CEREBELLAR INFORMATION STORAGE
    David J Linden; Fiscal Year: 2010
    ..Most work in this area has focused upon long-term potentiation and depression (LiP and LTD) of glutamatergic synapses...
  30. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2013
    ..The EVC patients have a short lip bound by frenum to alveolar ridge, which is also described as hyperplastic frena with a shallow labial sulcus, ..
  31. Growth Factor Signaling in Mouse Palatogensis
    YiPing Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...
  32. A role for the methyltransferase NSD3 in neural crest specification and migration
    Bridget T Jacques-Fricke; Fiscal Year: 2013
    ..Common birth defects such as cleft lip and palate result from abnormalities in neural crest cell development...
  33. CRCNS Detailed multi-neuron coding of decisions in parietal cortex
    JONATHAN WILLIAM PILLOW; Fiscal Year: 2013
    ..encoding and decoding of decision-related information by groups of neurons in lateral intraparietal cortex (area LIP), a brain region strongly implicated in decision-making...
  34. Dorsal midline patterning in the vertebrate CNS
    KATHLEEN JOYCE MILLEN; Fiscal Year: 2013
    ..Dorsal brain germinal zones, such as the cerebellar rhombic lip and telencephalic cortical hem, contribute substantially to neuronal diversity in the CNS, but the mechanisms that ..
  35. Role of actin cytoskeleton regulators in craniofacial development and disease
    Shuyi Nie; Fiscal Year: 2013
    ..Defects in their proliferation, migration, or survival lead to numerous diseases and birth defects, including cleft lip/palate, Treacher-Collins syndrome, and DiGeorge syndrome...
  36. Epigenetic Regulation in Cranial Neural Crest Development
    Na Hu; Fiscal Year: 2012
    ..Abnormal neural crest development can lead to a variety of birth defects such as craniofacial defects like cleft lip and palate, heart septation defects, and agangliogenesis of the colon...
  37. Genetic Characterization of a Novel Model of Cleft Palate
    Stephen A Murray; Fiscal Year: 2010
    ..Although an increasing number of genes have been linked to cleft lip and cleft palate, the mechanisms governing orofacial malformations remain unclear...
  38. Genetic and Morphometric Analysis of Facial Clefts
    REBECCA MICHELLE GREEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cleft lip (CL) or Cleft lip/palate (CL/P) occurs in about 1 in 700 live births, and while they are treatable, many individuals with these types of deformities will require lifelong care...
  39. Transcriptional Targets of PDGF Signaling during Craniofacial Development
    Harish Vasudevan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Craniofacial defects, such as cleft lip and/or palate, are the most prevalent congenital malformations worldwide...
  40. Metabolic changes in ovarian cancer cells initiated by metastasis to adipose tiss
    Ernst Lengyel; Fiscal Year: 2013
    ..induce both ?- oxidation and glycolysis in OvCa we propose, in Aim #2, to expand these studies with a detailed lip- idomic analysis of primary human OvCa cells and primary human adipocytes cultured alone and co- cultured in 3D ..
  41. Caregiver Responses to Nasoalveolar Molding and Early Cleft Care
    Hillary L Broder; Fiscal Year: 2013
    ..controversial, pre-surgical treatment aimed at improving cosmetic and functional outcomes among children with cleft lip and palate (CLP) through early intervention at about one month of age...
  42. Oral Clefts: Moving from Genome Wide Studies Toward Functional Genomics
    Terri H Beaty; Fiscal Year: 2013
    ..HEALTH RELEVANCE: This project is designed to follow up evidence from a genome wide study of oral clefts (cleft lip, cleft palate &cleft lip and palate) in a large international study of humans by sequencing specific genes to ..
  43. Characterizing the mechanisms of PDGFRalpha regulation in upper lip development
    Fenglei He; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cleft lip is one of most common birth defects. Caused by disruption of normal craniofacial development, cleft lip affects approximately 1 in 500 newborns worldwide...
  44. Molecular Interactions During Neural Crest Formation
    MARTIN IGNACIO GARCIA-CASTRO; Fiscal Year: 2013
    ..in neural crest development and homeostasis result in human pathologies or "neurocristopathies" that include cleft lip/palate, Waardenburg syndrome, and melanoma, amongst others...
  45. Extending the Phenotype of Nonsyndromic Orofacial Clefts
    Mary L Marazita; Fiscal Year: 2012
    Abstract Orofacial clefts (OFCs), particularly nonsyndromic cleft lip with or without cleft palate (NS CL/P) are a major public health problem, affecting one in every 500-1000 births worldwide...
  46. Super-resolution Reconstruction of Fetal Craniofacial MRI
    ALI GHOLIPOUR-BABOLI; Fiscal Year: 2012
    ..Nevertheless the diagnostic accuracy of sonography for complex craniofacial diseases such as cleft lip and cleft palate, hemifacial microsomia, micrognathia, etc. is extremely low...
  47. Characterizing early neural crest phosphoregulation using antiphosphatase targets
    Laura S Gammill; Fiscal Year: 2013
    ..MYH9 is phosphorylated, regulates cell motility (including metastasis), and associates with non-syndromic cleft lip and palate. However, MYH9 has not been characterized in the neural crest...
  48. Fiber bundle-based divided-pupil confocal endoscope
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..reflectance of nuclear and cellular detail in the epithelium, deeper connective tissue and blood flow in the inside lip-buccal mucosa in vivo. The optical sectioning is 1...
  49. Sleep and Neurobehavioral Performance After Cleft Palate Repair
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..In addition, 40 children of similar ages with previous repair of cleft lip only, excision of a mucocele, or a frenulectomy will be recruited to serve as controls...
  50. C/EBPb Modulates Macrophages and Tumor-Initiating Cells During Preneoplastic Prog
    Heather L Machado; Fiscal Year: 2013
    ..Accordingly, the following aims are proposed: Specific Aim 1: To determine whether C/EBP[unreadable]-LIP is required for preneoplastic progression and tumorigenesis...
  51. C/EBPb Modulates Macrophages and Tumor-Initiating Cells During Preneoplastic Prog
    Heather L Machado; Fiscal Year: 2012
    ..Accordingly, the following aims are proposed: Specific Aim 1: To determine whether C/EBP2-LIP is required for preneoplastic progression and tumorigenesis...
  52. The role of prdm1 in neural cell fate specification
    Kristin Bruk Artinger; Fiscal Year: 2010
    ..the genetic pathways that are important for neural tube and crest development, which in turn will be an important step in preventative measures in human congenital defects, such as spinal bifida and cleft lip and palate.
  53. Chromatin remodeling in multipotent neural crest formation and CHARGE syndrome
    Joanna Wysocka; Fiscal Year: 2013
    ..confer susceptibility to some of the most common birth defects, such as craniofacial dysmorphisms including cleft lip and/or palate, heart malformations and peripheral nervous system defects...
  54. The role of C/EBPbeta-3 in autophagy
    Maria M Abreu; Fiscal Year: 2011
    ..We hypothesize that an isoform ofthe C/EBPbeta transcription factor, C/EBPbeta-3 (or LIP), induces autophagy leading to massive cell death in human breast cancer cells...
  55. Skin Regeneration: Cellular &Molecular Mechanisms
    HERMANN PETER LORENZ; Fiscal Year: 2012
    Project Summary / Abstract Cleft lip and palate is a major health problem because of the functional defect produced. Furthermore, surgical reconstruction results in lip and palate scarring, which inhibits facial growth and oral function...
  56. Role of Interferon Regulatory Factor 6 (Irf6) in cutaneous wound healing
    Martine Dunnwald; Fiscal Year: 2010
    ..Previously, IRF6 was shown to be essential for the development of the lip and palate in humans. The objective of this proposal is to evaluate Irf6 in cutaneous wound healing...
  57. Methyl Donor Pathway Genetics in the Development of Orofacial Clefts
    JASPER D RINE; Fiscal Year: 2010
    ..Orofacial clefts, specifically cleft lip and cleft palate, are common and costly congenital anomalies whose etiologies remain largely unknown...
  58. Brain Structure, Function, and Growth in Children with Oral Cleft
    Peggy C Nopoulos; Fiscal Year: 2012
    ..to evaluate brain structure / function, and growth in subjects with non-syndromic or `isolated clefts of the lip and/or palate'(ICLP)...
  59. Discovering Human Birth Defect Genes from Chromosomal Rearrangements
    Richard L Maas; Fiscal Year: 2013
    ..We will focus on birth defects involving the craniofacial region (e.g., cleft lip and palate), the eye (e.g., congenital cataracts), and the kidney (e.g., vesicoureteral reflux, or VUR)...
  60. Mapping nonsyndromic cleft lip and palate genetic loci
    Jacqueline T Hecht; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common complex orofacial birth defect associated with significant morbidity and increased mortality...
  61. The role of Nectins in fusion of the midface and genesis of cleft lip and palate.
    TIMOTHY CHILTON COX; Fiscal Year: 2012
    Cleft lip and palate (CLP) is one of the most common congenital malformations in humans...
  62. Imaging and mechanistic analyses of face-brain dysmorphology in a CLP model
    Robert Lipinski; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Clefts of the lip and palate (CLP) are the most commonly occurring craniofacial birth defect, cause significant morbidity, and require extensive medical intervention...
  63. PHARMACOLOGY AND EFFICACY OF NOVEL TAXOL FORMULATIONS
    ROBERT STRAUBINGER; Fiscal Year: 1999
    ..We have developed taxol-liposome (T-lip) formulations that eliminate acute toxicity, reduce chronic toxicity, and in some cases enhance antitumor activity ..
  64. Enhanced Multimedia Telehealth for Hearing Disabilities
    Yunxin Zhao; Fiscal Year: 2005
    ..serious barriers in accessing current systems because of limited audio quality and limited sign language and lip reading capability...
  65. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  66. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2004
    Non-syndromic clefts of the lip and/or palate are among the most common malformations of the head and neck...
  67. WOUND HEALING AFTER FETAL CLEFT LIP REPAIR
    Leonard Kaban; Fiscal Year: 1990
    Although excellent esthetic and functional results can be achieved with post-natal cleft lip and palate repair, consecutive surgical procedures lead to scar formation and secondary midface growth retardation...
  68. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Encoded by an intronless gene, C/EBPB is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) whose expression is tightly regulated by the differential use of a number of in-frame translation start sites...
  69. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2004
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  70. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    Clefts of the lip and/or palate are among the most common and easily diagnosed birth defects, and can provide a model for complex trait analysis...
  71. Evaluating Low Ignition Propensity Cigarette Legislation
    RICHARD O CONNOR; Fiscal Year: 2009
    ..We propose five interrelated studies to investigate the effects of low ignition propensity (LIP) legislation on fire incidence, cigarette design, smoker behaviors, and toxin exposures...