molar

Summary

Summary: The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)

Top Publications

  1. ncbi Endodontic management of a maxillary first molar with two palatal canals with the aid of spiral computed tomography: a case report
    Vivek Aggarwal
    Department of Conservative Dentistry and Endodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India
    J Endod 35:137-9. 2009
  2. ncbi Maxillary first molar with seven root canals diagnosed with cone-beam computed tomography scanning: a case report
    Jojo Kottoor
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Tamil Nadu, India
    J Endod 36:915-21. 2010
  3. ncbi Root and canal morphology of mandibular first and second molar teeth in a Jordanian population
    A A Al-Qudah
    Department of Restorative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan
    Int Endod J 42:775-84. 2009
  4. ncbi Root and root canal morphology of the human permanent maxillary first molar: a literature review
    Blaine M Cleghorn
    Department of Dental Clinical Sciences, Dalhousie University, Halifax, Nova Scotia
    J Endod 32:813-21. 2006
  5. ncbi Identification of independent middle mesial canal in mandibular first molar using cone-beam computed tomography imaging
    Sung Ho La
    Seoul Miso Dental Clinic, Department of Conservative Dentistry, School of Dentistry, Wonkwang University, Iksan, South Korea
    J Endod 36:542-5. 2010
  6. ncbi Root and canal morphology of mandibular second molars in an Indian population
    Prasanna Neelakantan
    Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India
    J Endod 36:1319-22. 2010
  7. pmc Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar
    Keiko F Takahashi
    Laboratory of Oral Pathology and Medicine, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    BMC Dev Biol 10:115. 2010
  8. ncbi Root and canal morphology of Thai mandibular molars
    K Gulabivala
    Department of Conservative Dentistry, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Int Endod J 35:56-62. 2002
  9. pmc Remarkable resilience of teeth
    Herzl Chai
    School of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 106:7289-93. 2009
  10. ncbi Maxillary second molar with 5 roots and 5 canals evaluated using cone beam computerized tomography: a case report
    Jojo Kottoor
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Tamil Nadu, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e162-5. 2010

Detail Information

Publications391 found, 100 shown here

  1. ncbi Endodontic management of a maxillary first molar with two palatal canals with the aid of spiral computed tomography: a case report
    Vivek Aggarwal
    Department of Conservative Dentistry and Endodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India
    J Endod 35:137-9. 2009
    This case report presents the endodontic management of a maxillary first molar with 2 palatal canals with separate orifices and apical foramen. The diagnosis was confirmed with the help of spiral computed tomography...
  2. ncbi Maxillary first molar with seven root canals diagnosed with cone-beam computed tomography scanning: a case report
    Jojo Kottoor
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Tamil Nadu, India
    J Endod 36:915-21. 2010
    ..The purpose of this article was to emphasize the importance of having a thorough knowledge about the root canal anatomy...
  3. ncbi Root and canal morphology of mandibular first and second molar teeth in a Jordanian population
    A A Al-Qudah
    Department of Restorative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan
    Int Endod J 42:775-84. 2009
    To examine the root and canal morphology of mandibular permanent first and second molar teeth in a Jordanian population.
  4. ncbi Root and root canal morphology of the human permanent maxillary first molar: a literature review
    Blaine M Cleghorn
    Department of Dental Clinical Sciences, Dalhousie University, Halifax, Nova Scotia
    J Endod 32:813-21. 2006
    ..of this study was to review the literature with respect to the root and canal systems in the maxillary first molar. Root anatomy studies were divided into laboratory studies (in vitro), clinical root canal system anatomy studies (..
  5. ncbi Identification of independent middle mesial canal in mandibular first molar using cone-beam computed tomography imaging
    Sung Ho La
    Seoul Miso Dental Clinic, Department of Conservative Dentistry, School of Dentistry, Wonkwang University, Iksan, South Korea
    J Endod 36:542-5. 2010
    The root canal treatment of a mandibular molar with aberrant canal configuration can be diagnostically and technically challenging.
  6. ncbi Root and canal morphology of mandibular second molars in an Indian population
    Prasanna Neelakantan
    Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India
    J Endod 36:1319-22. 2010
    ..There are no reports on the root canal anatomy of Indian mandibular second molars. The aim of this study was to investigate the root and canal morphology of Indian mandibular second molars by a canal staining and tooth clearing technique...
  7. pmc Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar
    Keiko F Takahashi
    Laboratory of Oral Pathology and Medicine, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    BMC Dev Biol 10:115. 2010
    ..This study examined the functional implications of Prtg in the developing tooth germ of the mouse lower first molar.
  8. ncbi Root and canal morphology of Thai mandibular molars
    K Gulabivala
    Department of Conservative Dentistry, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Int Endod J 35:56-62. 2002
    ..To investigate the root and canal morphology of 351 mandibular permanent molars collected from an indigenous Thai population...
  9. pmc Remarkable resilience of teeth
    Herzl Chai
    School of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 106:7289-93. 2009
    ....
  10. ncbi Maxillary second molar with 5 roots and 5 canals evaluated using cone beam computerized tomography: a case report
    Jojo Kottoor
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Tamil Nadu, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e162-5. 2010
    This case report presents the endodontic management of maxillary right second molar exhibiting 5 roots and 5 root canals. The diagnosis was confirmed with the help of cone beam computerized tomography (CBCT)...
  11. ncbi Expression and role of Lhx8 in murine tooth development
    Tatsuya Shibaguchi
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Arch Histol Cytol 66:95-108. 2003
    ..Lhx8 was expressed in the dental mesenchyme between the bud and early bell stage of the molar tooth germ. Tooth germ explants from embryonic day 12...
  12. ncbi Impairment of spatial memory and changes in astroglial responsiveness following loss of molar teeth in aged SAMP8 mice
    M Onozuka
    Department of Anatomy, Gifu University School of Medicine, Japan
    Behav Brain Res 108:145-55. 2000
    ..for senile impairment of cognitive function as a result of reduced mastication, the effects of the loss of the molar teeth (molarless condition) on the hippocampal expression of glial fibrous acidic protein (GFAP) and on spatial ..
  13. ncbi Tooth anomalies associated with failure of eruption of first and second permanent molars
    T Baccetti
    Department of Orthodontics, The University of Florence, Italy
    Am J Orthod Dentofacial Orthop 118:608-10. 2000
    ..001). No significant association was found among the occurrence of molar eruption disturbances, aplasia of premolars, and small-sized laterals...
  14. ncbi Evaluation of root and canal systems of mandibular first molars in Taiwanese individuals using cone-beam computed tomography
    Chih Chia Huang
    Department of Dentistry, Cardinal Tien Hospital, Taipei, Taiwan
    J Formos Med Assoc 109:303-8. 2010
    ..Cone-beam computed tomography (CBCT) can provide valuable data for root canal systems of human teeth. This study used CBCT to evaluate the number of roots and canals in mandibular first molars in Taiwanese individuals...
  15. ncbi Teasing apart the contributions of hard dietary items on 3D dental microtextures in primates
    Ivan Calandra
    Biocenter Grindel and Zoological Museum, University of Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    J Hum Evol 63:85-98. 2012
    ....
  16. ncbi Validation of the Eichner index in relation to occlusal force and masticatory performance
    Kazunoir Ikebe
    Department of Prosthodontics and Oral Rehabilitation, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka, Japan
    Int J Prosthodont 23:521-4. 2010
    ....
  17. ncbi Comparison of sandblasting, laser irradiation, and conventional acid etching for orthodontic bonding of molar tubes
    Nuket Berk
    Dentaform Health Center, Anakra, Turkey
    Eur J Orthod 30:183-9. 2008
    ..study was to determine if sandblasted and laser-irradiated enamel may be viable alternatives to acid etching for molar tube bonding. Seventy-seven molar teeth extracted for periodontal reasons were used...
  18. pmc Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons
    L Tarsa
    Department of Integrative Biosciences, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA
    Neuroscience 167:1205-15. 2010
    ..Overall, the inflammation-induced upregulation of BDNF is stronger in mice compared to rats. Thus, mouse TG provides a suitable model to study molecular mechanisms of inflammation-dependent regulation of BDNF expression in vivo...
  19. ncbi Endodontic management of a fused mandibular second molar and paramolar with the aid of spiral computed tomography: a case report
    Suma Ballal
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India
    J Endod 33:1247-51. 2007
    ..In this article, we report a rare case of successful endodontic management of unilateral fused mandibular second molar with a paramolar...
  20. ncbi An unusual maxillary first molar with four roots and six canals: a case report
    N Adanir
    Department of Endodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta, Turkey
    Aust Dent J 52:333-5. 2007
    This case report presents an unusual maxillary right first molar with four roots and six canals. Endodontic treatment was provided and final restoration was accomplished with composite resin...
  21. ncbi C-shaped root canal system in mandibular second molars in a Chinese population evaluated by cone-beam computed tomography
    Q Zheng
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
    Int Endod J 44:857-62. 2011
    ..To evaluate the anatomical features of C-shaped canal systems in Chinese mandibular second molars by cone-beam computed tomography (CBCT)...
  22. ncbi Efficiency of a skeletonized distal jet appliance supported by miniscrew anchorage for noncompliance maxillary molar distalization
    Gero S M Kinzinger
    Department of Orthodontics, University of Saarland, Homburg Saar, Germany
    Am J Orthod Dentofacial Orthop 136:578-86. 2009
    Conventional anchorage appliances rely exclusively on intraoral anchorage for noncompliance molar distalization. The partial coverage of the palate, in particular, often results in compromised oral hygiene...
  23. ncbi A Micro CT study of the mesiobuccal root canal morphology of the maxillary first molar tooth
    P Verma
    Department of Oral Diagnostic and Surgical Sciences, University of Otago School of Dentistry, Dunedin, New Zealand
    Int Endod J 44:210-7. 2011
    To observe the morphology of the root canal system of the maxillary first molar mesiobuccal root using micro computed tomography and compare it to current canal classifications.
  24. ncbi Effects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germ
    Amer Sehic
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Physiol Genomics 43:488-98. 2011
    ..MicroRNA-214 (miR-214), encoded by the polycistronic Dnm30os gene, is highly expressed during development of molar tooth germ and was selected as a target for silencing with anti-miR-214...
  25. pmc Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity
    Kazunori Adachi
    Department of Physiology, Nihon University School of Dentistry, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai Chiyoda ku, Tokyo, 101 8310, Japan
    Mol Pain 6:59. 2010
    ..noxious pulp stimulation, the P2X3 and P2X2/3 receptor agonist α,β-methyleneATP (α,β-meATP) was applied to the molar tooth pulp and nocifensive behavior and extracellular-signal regulated kinase (ERK) phosphorylation in trigeminal ..
  26. ncbi C-shaped root canal in a maxillary first molar: a case report
    Z Yilmaz
    Department of Endodontics, Faculty of Dentisty, Hacettepe University, Ankara, Turkey
    Int Endod J 39:162-6. 2006
    This case report presents an unusual C-shaped root canal system in a maxillary first molar tooth.
  27. ncbi Middle distal canal of the mandibular first molar: a case report and literature review
    J Kottoor
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India
    Int Endod J 43:714-22. 2010
    To present a clinical case report in a mandibular first molar with a middle distal canal, along with a review of the literature.
  28. ncbi Evaluation of periapical radiographs in the recognition of C-shaped mandibular second molars
    T Lambrianidis
    Department of Endodontology, Dental School, Aristotelian University, Thessaloniki, Greece
    Int Endod J 34:458-62. 2001
    ....
  29. ncbi Root and canal morphology of permanent mandibular molars in a Sudanese population
    H A Ahmed
    Conservative Dentistry Division, Department of Oral Rehabilitation, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan
    Int Endod J 40:766-71. 2007
    To investigate variations in the root canal systems of first and second permanent mandibular molar teeth in a Sudanese population using a clearing technique.
  30. ncbi Root anatomy and canal configuration of the permanent mandibular first molar: a systematic review
    Oliver Valencia de Pablo
    Department of Endodontics, Universidad Europea de Madrid, Madrid, Espana
    J Endod 36:1919-31. 2010
    ..The purpose of this study was to review published literature related to root anatomy and root canal configuration of the permanent mandibular first molar.
  31. ncbi Skeletal anchorage system for open-bite correction
    M Umemori
    School of Dentistry, Tohoku University, Sendai, Japan
    Am J Orthod Dentofacial Orthop 115:166-74. 1999
    ..Elastic threads were used as a source of orthodontic force to reduce excessive molar height...
  32. ncbi The C-shaped root canal configuration: a review
    Hamid Jafarzadeh
    Department of Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
    J Endod 33:517-23. 2007
    ..Because of the importance of its true diagnosis and treatment, a comprehensive review of published information and investigations about it in addition to approaches for its treatment is necessary...
  33. ncbi Functional ecology and evolution of hominoid molar enamel thickness: Pan troglodytes schweinfurthii and Pongo pygmaeus wurmbii
    Erin R Vogel
    Department of Anthropology, 1156 High Street, University of California Santa Cruz, CA 95064, United States
    J Hum Evol 55:60-74. 2008
    The divergent molar characteristics of Pan troglodytes and Pongo pygmaeus provide an instructive paradigm for examining the adaptive form-function relationship between molar enamel thickness and food hardness...
  34. ncbi C-shaped root canals in mandibular second molars in a Saudi Arabian population
    K S Al-Fouzan
    Dental Department, King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia
    Int Endod J 35:499-504. 2002
    ..The aim of this study was to determine the frequency of C-shaped canals in mandibular second molars in a population in Saudi Arabia and to establish a classification for the most common configurations...
  35. pmc Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse
    H Fong
    Department of Materials Science and Engineering, University of Washington, Seattle, WA, USA
    J Periodontol 80:1348-54. 2009
    ..Here, we report a developmental study of tooth root formation in Hyp mouse molars, focusing on dentin and cementum...
  36. ncbi The evaluation of root canal morphology of the mandibular first molar in an Indian population using spiral computed tomography scan: an in vitro study
    Joseph Reuben
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College, Tamil Nadu, India
    J Endod 34:212-5. 2008
    ..48%) had the 3 canal (mesiobuccal, mesiolingual, and 1 distal canal) configuration and that the cementoenamel junction coincided with the roof of the pulp chamber in 37.09% of the samples only...
  37. ncbi Changes in the septohippocampal cholinergic system following removal of molar teeth in the aged SAMP8 mouse
    Minoru Onozuka
    Department of Anatomy 2nd Division, Gifu University School of Medicine, 40 Tsukasa Machi, Japan
    Behav Brain Res 133:197-204. 2002
    ..nucleus and the vertical limb of the diagonal band in young-adult and aged SAMP8 mice after removal of their upper molar teeth (molarless condition)...
  38. ncbi Apexogenesis of a symptomatic molar with calcium enriched mixture
    A Nosrat
    Department of Endodontics, Dental School, Rafsanjan University of Medical Sciences, Rafsanjan, Kerman, Iran
    Int Endod J 43:940-4. 2010
    This article describes the apexogenesis of a mandibular right second molar in a 12-year-old girl who was referred with a history of lingering pain and pain on chewing.
  39. ncbi Identification of a nonsense mutation in the PAX9 gene in molar oligodontia
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Hum Genet 9:743-6. 2001
    ..Here we report a nonsense mutation in the PAX9 gene that is associated with molar tooth agenesis in a Finnish family...
  40. ncbi Dental microwear patterns of extant and extinct Muridae (Rodentia, Mammalia): ecological implications
    Helder Gomes Rodrigues
    Laboratoire de Paléontologie Paléobiologie Phylogénie, Institut des Sciences de l Evolution de l Université Montpellier II, UMR CNRS 5554 Case courrier 064, Place Eugene Bataillon, 34 095, Montpellier Cedex 5, France
    Naturwissenschaften 96:537-42. 2009
    ..These results concur with the presence of open to woodland areas covered by an herbaceous vegetal layer, including monocotyledons, in the vicinity of this mid-Pliocene locality...
  41. ncbi C-shaped canal system in mandibular second molars: Part I--Anatomical features
    Bing Fan
    Key Lab for Oral Biomedical Engineering of Ministry of Education, Endodontic Center, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    J Endod 30:899-903. 2004
    ..Section 2 of this paper addressed the correlation between the radiographic appearance and these microCT images...
  42. ncbi The effect of fibre insertion on fracture resistance of root filled molar teeth with MOD preparations restored with composite
    S Belli
    Department of Endodontics, Faculty of Dentistry, Selcuk University, Konya, Turkey
    Int Endod J 38:73-80. 2005
    ..To evaluate the effect of using flowable composite with or without leno woven ultra high modulus polyethylene fibre reinforcement on fracture resistance of root filled mandibular molars with mesio-occlusodistal (MOD) preparations...
  43. ncbi Nanoindentation mapping of the mechanical properties of human molar tooth enamel
    J L Cuy
    Department of Materials Science and Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Arch Oral Biol 47:281-91. 2002
    ..used nanoindentation to map out the properties of dental enamel over the axial cross-section of a maxillary second molar (M(2))...
  44. ncbi Buonocore Memorial Lecture. Review of the clinical survival of direct and indirect restorations in posterior teeth of the permanent dentition
    Juergen Manhart
    Department of Restorative Dentistry and Periodontology, Ludwig Maximilians University, Munich, Germany
    Oper Dent 29:481-508. 2004
    ..We need to learn to distinguish between reasons that cause early failures and those that are responsible for restoration loss after several years of service...
  45. ncbi Middle mesial canal of the mandibular first molar: a case report and literature review
    Dean Baugh
    University of Pittsburgh School of Dental Medicine, Pennsylvania, USA
    J Endod 30:185-6. 2004
    ..or microscope, the astute clinician must be aware of recent literature that states that the mandibular first molar has a 1-15% chance of a fifth canal...
  46. ncbi Rationalization of shape and related stress distribution in posterior teeth: a finite element study using nonlinear contact analysis
    Pascal Magne
    Department of Prosthodontics, School of Dental Medicine, University of Geneva, Switzerland
    Int J Periodontics Restorative Dent 22:425-33. 2002
    ..High stress levels were found in the central groove of the maxillary molar during nonworking micromotion and at the lingual surface of enamel of the mandibular tooth during single-contact ..
  47. ncbi Validity of scoring caries and primary molar hypomineralization (DMH) on intraoral photographs
    M E C Elfrink
    Dept Cariology, Endodontology and Pedodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    Eur Arch Paediatr Dent 10:5-10. 2009
    ..intraoral photographs could be used to score caries and hypomineralization on primary molars (Using adapted Molar Incisor Hypomineralization (MIH)-criteria), and also to assess the reliability and validity in 3-7 year-old Dutch ..
  48. ncbi Three-dimensional analysis of maxillary first molar mesiobuccal root canal configuration and curvature using micro-computed tomography
    Jong Wook Park
    Department of Oral Anatomy, Seoul National University, Seoul, South Korea
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:437-42. 2009
    The complex anatomic configuration of the maxillary first molar mesiobuccal (MB) root canal system has been the subject of several studies...
  49. ncbi Endodontic management of a maxillary first molar with a single root and a single canal diagnosed with the aid of spiral CT: a case report
    Velayutham Gopikrishna
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College, Alapakkam Main Road, Maduravoyal, Chennai, India
    J Endod 32:687-91. 2006
    The aim of this article is to present an endodontically managed maxillary first molar with an unusual morphology of a single root and a single canal, which has not been reported in the literature so far...
  50. ncbi The morphologic characteristics of the distolingual roots of mandibular first molars in a Taiwanese population
    Yi Chen Chen
    Department of Stomatology, Division of Endodontics and Periodontology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Endod 35:643-5. 2009
    ..The purpose of this study was to evaluate the difference of root length and root curvatures between distobuccal (DB) and DL roots of three-rooted mandibular first molars in a Taiwanese (Chinese) population...
  51. ncbi Impaction and retention of second molars: diagnosis, treatment and outcome. A retrospective follow-up study
    Cathrine Magnusson
    The County Orthodontic Clinic in Borås, Boras, Sweden
    Angle Orthod 79:422-7. 2009
    To evaluate treatment outcome in patients with second molar impaction and retention.
  52. ncbi Skeletal maturation evaluation using mandibular second molar calcification stages
    Sushil Kumar
    Department of Orthodontics, PDM Dental College and Research Institute, Sarai Aurangabad, Bahadurgarh, Haryana, India
    Angle Orthod 82:501-6. 2012
    To investigate (1) the relationships between the stages of mandibular second molar calcification and skeletal maturity; and (2) whether second molar calcification stages can be used as a reliable diagnostic tool to determine skeletal ..
  53. ncbi Variation in hominoid molar enamel thickness
    Tanya M Smith
    Interdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, NY 11794 4364, USA
    J Hum Evol 48:575-92. 2005
    ..Nonetheless, previous findings that African apes have relatively thinner enamel than Pongo is supported for certain molar positions.
  54. ncbi Use of cone-beam computed tomography to evaluate root and canal morphology of mandibular molars in Chinese individuals
    R Zhang
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    Int Endod J 44:990-9. 2011
    To evaluate the root canal configuration of permanent mandibular first and second molar teeth in a Chinese subpopulation using cone-beam computed tomography (CBCT).
  55. ncbi Mandibular first molar having an unusual mesial root canal morphology with contradictory cone-beam computed tomography findings: a case report
    Jogikalmat Krithikadatta
    Rajan Dental Institute, Mylapore, Chennai, Tamil Nadu, India
    J Endod 36:1712-6. 2010
    ..The objective of this article is to highlight the importance of having a thorough knowledge about the root canal anatomy and the possibility of misleading findings in the cone-beam computed tomography (CBCT) images...
  56. ncbi Anatomical study of C-shaped canals in mandibular second molars by analysis of computed tomography
    Guang Chun Jin
    Binzhou Medical College, Shan dong, China
    J Endod 32:10-3. 2006
    ..from the center of the canal to the outer surface of the deepest groove area in C-shaped mandibular second molar to that of "danger zone of perforation" in normal mandibular second molar...
  57. pmc Molar macrowear reveals Neanderthal eco-geographic dietary variation
    Luca Fiorenza
    Department of Palaeoanthropology and Messel Research, Senckenberg Research Institute, Frankfurt am Main, Germany
    PLoS ONE 6:e14769. 2011
    ..We analyzed molar wear patterns using occlusal fingerprint analysis derived from optical 3D topometry...
  58. pmc The Prx1 homeobox gene is critical for molar tooth morphogenesis
    J M Mitchell
    Department of Cell Biology and Anatomy, Suite 601, Medical University of South Carolina, 171 Ashley Avenue, Charleston, NC 29435, USA
    J Dent Res 85:888-93. 2006
    ..Since the posterior mandibular region was relatively normal, we examined molar tooth development in Prx1(-/-)/Prx2(-/-) embryos to determine whether the tooth malformation is primary to the ..
  59. pmc Expression of clock proteins in developing tooth
    Li Zheng
    Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Gene Expr Patterns 11:202-6. 2011
    ..Our data suggests that clock genes might be involved in the regulation of ameloblast and odontoblast functions, such as enamel and dentin protein secretion and matrix mineralization...
  60. ncbi Caries rates for the mesial surface of the first permanent molar and the distal surface of the second primary molar from 6 to 12 years of age in Sweden
    I Mejare
    Department of Paediatric Dentistry, Eastman Dental Institute, Stockholm, Sweden
    Caries Res 34:454-61. 2000
    ..The aim was to analyse the pattern of caries rates in enamel and dentin of the mesial surface of the first permanent molar (mesial 16, 26,36,46; here called 6m) and the distal surface of the second primary molar (distal 55,65,75,85; here ..
  61. ncbi Identification of novel transcription-regulating genes expressed during murine molar development
    Kenta Uchibe
    Department of Systems Biomedicine, National Research Institute for Child Health and Development, Setagaya, Japan
    Dev Dyn 241:1217-26. 2012
    ..However, detailed molecular mechanisms of tooth development have not been completely elucidated, partially because numerous genes that play essential roles in tooth development remain unidentified...
  62. ncbi Mandibular disto-lingual root: a consideration in periodontal therapy
    Ren Yeong Huang
    Department of Periodontology, School of Dentistry, National Defense Medical Center, Taipei, Taiwan
    J Periodontol 78:1485-90. 2007
    ..Although the presence of a disto-lingual root in the mandibular first molar is rare, its role in periodontal destruction has not been examined...
  63. ncbi Dental functional status in a southern vietnamese adult population-a combined quantitative and qualitative classification system analysis
    Thoa C Nguyen
    Department of Prosthodontics, Can Tho University of Medicine and Pharmcay, Can Tho, Vietnam
    Int J Prosthodont 24:30-7. 2011
    ..The aim of this study was to explore the dental functional status of a Southern Vietnamese adult population using a new quantitative- and qualitative-based classification system...
  64. ncbi Treatment of proximal superficial caries lesions on primary molar teeth with resin infiltration and fluoride varnish versus fluoride varnish only: efficacy after 1 year
    K R Ekstrand
    Department of Cariology and Endodontics, School of Dentistry, University of Copenhagen, Copenhagen, Denmark
    Caries Res 44:41-6. 2010
    ..lesions covered by fluoride varnish (FV) versus FV treatment only of proximal lesions on deciduous molar teeth. The study lasted for 1 year...
  65. pmc Enamel hypoplasia in molars of sheep and goats, and its relationship to the pattern of tooth crown growth
    H Kierdorf
    Department of Biology, University of Hildesheim, Hildesheim, Germany
    J Anat 220:484-95. 2012
    ..In these cases, microscopic analysis of tooth sections is required for a correct diagnosis of the hypoplastic enamel defects...
  66. ncbi Amoxicillin may cause molar incisor hypomineralization
    S Laisi
    Health Center, Ylämaa, Finland
    J Dent Res 88:132-6. 2009
    The etiology of molar incisor hypomineralization (MIH) is unclear. Our hypothesis was that certain antibiotics cause MIH...
  67. ncbi Identification of a C-shaped canal system in mandibular second molars-part II: the effect of bone image superimposition and intraradicular contrast medium on radiograph interpretation
    Bing Fan
    Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Endodontic Center, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    J Endod 34:160-5. 2008
    ....
  68. ncbi Identification of C-shaped canal in mandibular second molars. Part I: radiographic and anatomical features revealed by intraradicular contrast medium
    Wei Fan
    Key Lab for Oral Biomedical Engineering of Ministry of Education, Endodontic Center, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    J Endod 33:806-10. 2007
    ..05). On the basis of these results, the radiographic features revealed by the intraradicular contrast medium can help to identify the canal anatomy of C-shaped canal system in mandibular second molars...
  69. ncbi Prevalence of three-rooted mandibular first molars among Taiwanese individuals
    Ming Gene Tu
    Graduate Institute of Dental Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Endod 33:1163-6. 2007
    ..Clinicians should be aware of the high racial prevalence of the distolingual root in mandibular first molars among the Taiwanese (Chinese) population before initiating endodontic treatment...
  70. ncbi Third canal in the mesial root of permanent mandibular first molars: review of the literature and presentation of 3 clinical reports and 2 in vitro studies
    Leopoldo Forner Navarro
    Dental Pathology and Therapeutics Unit, University of Valencia, Valencia, Spain
    Med Oral Patol Oral Cir Bucal 12:E605-9. 2007
    ..Systematic anatomical studies corroborate the anatomical complexity of the root canal system. Deviations from the norm such as multiple orifices, apical deltas, accessory canals and other variations are frequent...
  71. ncbi Molar development in common chimpanzees (Pan troglodytes)
    T M Smith
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    J Hum Evol 52:201-16. 2007
    ..histological study suggested that there is little or no time between age at chimpanzee crown completion and age at molar eruption, which is unlikely given that root growth is necessary for tooth eruption...
  72. ncbi Mandibular molar root morphology in Neanderthals and Late Pleistocene and recent Homo sapiens
    Kornelius Kupczik
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    J Hum Evol 59:525-41. 2010
    ..Yet, there is little known about variation in molar root morphology in Neanderthals and other recent and fossil members of Homo...
  73. ncbi Endodontic management of a maxillary first molar with eight root canal systems evaluated using cone-beam computed tomography scanning: a case report
    Jojo Kottoor
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Chennai Tamil Nadu, India
    J Endod 37:715-9. 2011
    ..Root canal treatment of maxillary molars presenting with complex root canal configurations can be diagnostically and technically challenging...
  74. ncbi Quantitative investigation of palatal bone depth and cortical bone thickness for mini-implant placement in adults
    Sebastian Baumgaertel
    Department of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Orthod Dentofacial Orthop 136:104-8. 2009
    ..The purpose of this study was to investigate both variables in the palate quantitatively to aid clinicians in planning successful mini-implant placements...
  75. ncbi Msx1 controls inductive signaling in mammalian tooth morphogenesis
    Y Chen
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 122:3035-44. 1996
    ..for Msx1 exhibit defects in craniofacial development and a failure of tooth morphogenesis, with an arrest in molar tooth development at the E13.5 bud stage...
  76. ncbi Frequency of agenesis, impaction, angulation, and related pathologic changes of third molar teeth in orthodontic patients
    Mevlut Celikoglu
    Department of Orthodontics, Faculty of Dentistry, Ataturk University, Erzurum, Turkey
    J Oral Maxillofac Surg 68:990-5. 2010
    The objectives of the present study were to investigate the frequency of impaction, agenesis, angular position, and related pathologic changes of third molar teeth in a group of orthodontic patients.
  77. ncbi The chronology of second and third molar development in Koreans and its application to forensic age estimation
    Sang Seob Lee
    Division of Forensic Medicine, National Forensic Service, 331 1 Shinwol 7 dong, Yangcheon Gu, Seoul, 158 707, South Korea
    Int J Legal Med 124:659-65. 2010
    The accuracy of forensic age estimation based on the chronology of second (M2) and third molar (M3) development was investigated using 2,087 orthopantomograms of Korean men and women aged between 3 and 23 years...
  78. ncbi Internal resorption treated with mineral trioxide aggregate in a primary molar tooth: 18-month follow-up
    Saziye Sari
    Department of Pedodontics, Faculty of Dentistry, University of Ankara, Ankara, Turkey
    J Endod 32:69-71. 2006
    Mineral trioxide aggregate (MTA) repair of a mandibular second-primary molar tooth with an inflammatory resorptive defect in the coronal third of the root canal is reported in this case...
  79. pmc Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation
    Tae Yeon Lee
    Department of Conservative Dentistry and Dental Research Institute, College of Dentistry, Seoul National University, 28 Yeon Gun Dong, Jong Ro Gu, Seoul 110 749, Korea
    J Histochem Cytochem 57:469-76. 2009
    We reported previously that Nfic-deficient mice exhibit short and abnormal molar roots and severely deformed incisors...
  80. ncbi Three-dimensional visualization of a mandibular first molar with three distal roots using computer-aided rapid prototyping
    Seung Jong Lee
    Department of Conservative Dentistry, Faculty of Dentistry, Yonsei University, Seoul, South Korea
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:668-74. 2006
    Nonsurgical endodontic therapy of a right mandibular first molar with 3 distal roots was successfully performed with the aid of magnification...
  81. ncbi The influence of zirconia coping designs on the fracture load of all-ceramic molar crowns
    Yuji Kokubo
    Department of Fixed Prosthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan
    Dent Mater J 30:281-5. 2011
    ....
  82. ncbi Mineral trioxide aggregate repair of a perforating internal resorption in a mandibular molar
    Maarten Meire
    Department of Operative Dentistry and Endodontology, Dental School, Ghent University, Ghent University Hospital, Gent, Belgium
    J Endod 34:220-3. 2008
    ..This article describes treatment of a perforating internal resorption in the mesial root of a second lower molar, with adjacent destruction of the alveolar bone...
  83. ncbi Immediate transmucosal implant placement in molar extraction sites: a 12-month prospective multicenter cohort study
    C Cafiero
    Department of Dental and Maxillofacial Sciences, University of Naples Federico II, Naples, Italy
    Clin Oral Implants Res 19:476-82. 2008
    To assess the clinical and radiographic outcomes of immediate transmucosal placement of implants into molar extraction sockets.
  84. ncbi Mandibular second molar impaction. Part I: Genetic traits and characteristics
    Yehoshua Shapira
    Department of Orthodontics, Maurice and Gabriela Goldshleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Orthod Dentofacial Orthop 140:32-7. 2011
    Detection of mandibular second molar (MM2) impaction is imperative for orthodontic diagnosis and treatment. In this study, we examined a possible genetic trait in MM2 impaction in 2 populations and defined distinctive characteristics.
  85. ncbi A novel mutation in PAX9 causes familial form of molar oligodontia
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
    Eur J Hum Genet 14:173-9. 2006
    ..The present report describes an unusual novel mutation in PAX9 identified in a family with severe molar oligodontia...
  86. ncbi Observations on continuously growing roots of the sloth and the K14-Eda transgenic mice indicate that epithelial stem cells can give rise to both the ameloblast and root epithelium cell lineage creating distinct tooth patterns
    Mark Tummers
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Evol Dev 10:187-95. 2008
    ..Similarly we show that continuously growing roots represented by the sloth molar and K14-Eda transgenic incisor maintain a cervical loop with a small core of stellate reticulum cells around the ..
  87. ncbi Determining the cessation of vertical growth of the craniofacial structures to facilitate placement of single-tooth implants
    Piotr Fudalej
    National Research Institute for Mother and Child, Warsaw, Poland
    Am J Orthod Dentofacial Orthop 131:S59-67. 2007
    ..The purposes of this study were to determine and quantify the amount of vertical growth of the facial skeleton and the amount of eruption of the central incisors and the maxillary first molars after puberty...
  88. ncbi Brief communication: comparing loading scenarios in lower first molar supporting bone structure using 3D finite element analysis
    Stefano Benazzi
    Department of Anthropology, University of Vienna, Austria
    Am J Phys Anthropol 147:128-34. 2012
    ..In this pilot study we show how lower first molar occlusal information can be used to investigate the stress distribution with 3D FEA in the supporting bone ..
  89. ncbi Three-dimensional analysis of mesiobuccal root canal of Japanese maxillary first molar using Micro-CT
    Masashi Yamada
    Department of Endodontics and Clinical Cariology, Tokyo Dental College
    Bull Tokyo Dent Coll 52:77-84. 2011
    ..This result may be explained by the far more superior visualization ability of Micro-CT than conventional methods, which allowed the detection of microscopic apical ramifications previously difficult to observe...
  90. ncbi Cellular and extracellular factors in early root resorption repair in the rat
    Andreas Jager
    Department of Orthodontics, University of Bonn, Bonn, Germany
    Eur J Orthod 30:336-45. 2008
    ..Cells with a defined osteoblastic phenotype seemed to be of minor importance in this repair process...
  91. ncbi Maxillary molar intrusion with fixed appliances and mini-implant anchorage studied in three dimensions
    Chung Chen Jane Yao
    Department of Orthodontics, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Angle Orthod 75:754-60. 2005
    The intrusion of an overerupted maxillary molar using traditional orthodontic treatment is a real challenge...
  92. ncbi Endodontic treatment of a mandibular first molar with three mesial canals and broken instrument removal
    Farhad Faramarzi
    Department of Endodontics, Dental School, Shaheed Behesti University of Medical Sciences, Tehran, Iran
    Aust Endod J 36:39-41. 2010
    ..This case report presents the endodontic treatment of a mandibular first molar exhibiting three mesial root canals with 4 mm of a separated K-file in the coronal third of the mesiolingual canal ..
  93. ncbi Brief communication: Contributions of enamel-dentine junction shape and enamel deposition to primate molar crown complexity
    Matthew M Skinner
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, 04103, Germany
    Am J Phys Anthropol 142:157-63. 2010
    b>Molar crown morphology varies among primates from relatively simple in some taxa to more complex in others, with such variability having both functional and taxonomic significance...
  94. ncbi Hepatocyte growth factor stimulates root growth during the development of mouse molar teeth
    H Sakuraba
    Division of Orthodontics, Department of Developmental Oral Health Science, Iwate Medical University, Morioka, Iwate, Japan
    J Periodontal Res 47:81-8. 2012
    ..As hepatocyte growth factor (HGF) is one of the mediators of epithelial-mesenchymal interactions in rodent tooth, the objective of this study was to examine the effects of HGF on the root development of mouse molars...
  95. ncbi Spiral CT diagnosis and endodontic management of an anatomically variant palatal root with two canals in a maxillary first molar
    Mohanavelu Deepalakshmi
    Department of Conservative Dentistry and Endodontics, Ragas Dental College and Hospital, Uthandi, Chennai, India
    Indian J Dent Res 21:443-5. 2010
    ..management of an anatomically variant palatal root with 2 canals (Vertucci type II) in a maxillary first molar, which was confirmed with the help of spiral computed tomography (SCT)...
  96. ncbi Identification of a novel FAM83H mutation and microhardness of an affected molar in autosomal dominant hypocalcified amelogenesis imperfecta
    H K Hyun
    Department of Pediatric Dentistry, Dental Research Institute and BK21 Program, School of Dentistry, Seoul National University, Seoul, Korea
    Int Endod J 42:1039-43. 2009
    ..To determine the underlying molecular genetic aetiology of a family with the hypocalcified form of amelogenesis imperfecta and to investigate the hardness of the enamel and dentine of a known FAM83H mutation...
  97. ncbi Survival analyses of surgical miniscrews as orthodontic anchorage
    Nita Viwattanatipa
    Department of Orthodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
    Am J Orthod Dentofacial Orthop 136:29-36. 2009
    ..The objectives of this study were to determine the survival rate of titanium surgical miniscrews and the clinical parameters that posed the highest risks for failure...
  98. ncbi Treatment of a second maxillary molar with six canals
    Braulio Pasternak Júnior
    UNISUL, Tubarao, Santa Catarina, Brazil
    Aust Endod J 33:42-5. 2007
    ..The purpose of this study is to present a clinical case of a maxillary second molar with three palatal canals, two mesio-buccal and one disto-buccal canal...
  99. ncbi Microbial profile of ligature-induced periodontitis in rats
    Poliana Mendes Duarte
    Department of Periodontics, Dental Research Division, Guarulhos University, Guarulhos, Sao Paulo, Brazil
    Arch Oral Biol 55:142-7. 2010
    ..The aim of this study was to evaluate the composition of the biofilm accumulated around ligatures in rats by checkerboard DNA-DNA hybridization using probes made from human oral bacterial species...
  100. ncbi Mandibular molar with five root canals
    Fernando Branco Barletta
    Universidade de Santa Cruz do Sul, Departamento de Enfermagern e Odontologia, Santa Cruz do Sul, RS, Brazil
    Aust Endod J 34:129-32. 2008
    ..In this report, the authors describe the endodontic treatment of a mandibular first molar with five root canals, evaluate the rate of occurrence of this number of canals, and discuss the importance of ..
  101. ncbi Improved resin infiltration of natural caries lesions
    H Meyer-Lueckel
    Department of Operative Dentistry and Periodontology, CharitéCentrum for Dental Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Dent Res 87:1112-6. 2008
    ..001; Wilcoxon). It can be concluded that resins with higher PCs (infiltrants) show superior ability to penetrate natural lesions compared with resins with lower PCs...

Research Grants67

  1. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..CST deficient Chga-KO mice show high MIC, as judged by C-peptide/insulin molar ratio, leading to low level of insulin...
  2. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ..to conduct a prospective cohort study of initially 5 to 11 year-old children with at least one carious primary molar (1 to 3 surfaces cavitated) that has been restored with ART or amalgam...
  3. The role of NLRP7 and related genes in hydatidiform moles and reproductive failur
    Ignatia Van den Veyver; Fiscal Year: 2009
    ..are clinically and pathologically identical to AnCHM, but have normal biparental inheritance (BiHM) and their molar trophoblast tissues show abnormal expression of imprinted genes and abnormal methylation of CpG islands at ..
  4. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    ..On a molar basis, mAbs directed against CPS fix less C4b than mAbs against membrane structures, suggesting that efficient C4b ..
  5. Screening for allosteric modulators of the protease activated receptor 4
    Heidi E Hamm; Fiscal Year: 2013
    ..compounds will avoid the difficulty that comes from trying to displace the tethered ligand which is present at molar concentrations...
  6. Prevention of diabetes by pDNA encoded with IL-10
    Jagdish Singh; Fiscal Year: 2010
    ..using monomers, 2- dimethyl amino ethyl methacrylate (DMAEMA) and methylmethacrylate (MMA) with increasing molar ratio of DMAEMA...
  7. Joubert Syndrome Biennial Conference: Advancing Translational Ciliopathy Research
    DANIEL A DOHERTY; Fiscal Year: 2013
    ..JS) is a debilitating neurodevelopmental disorder characterized by a distinctive hindbrain malformation (the "molar tooth sign") combined with hypotonia, developmental delay, ataxia, and variable features such as cystic renal ..
  8. Mechanism of Metabolism of S-Nitrosothiols
    Neil Hogg; Fiscal Year: 2010
    ..In addition S-nitrosoglutathione (GSNO) has been detected in micro molar concentration in lung lavage and is decreased in asthma...
  9. HIV integrase/DNA complexes and concerted integration
    Duane P Grandgenett; Fiscal Year: 2010
    ..the ability of IN to protect the terminal U5 and U3 DNA sequences from DNaseI digestion and determine the molar ratios of chemically cross-linked dimers, tetramers and a larger-size multimer of IN located in the SC...
  10. DISCOVERY OF CHEMICAL PROBES FOR METHYL-LYSINE READERS
    STEPHEN VERNON FRYE; Fiscal Year: 2013
    ..We have discovered small molecule ligands for the methyl-lysine readers, L3MBTL3 and L3MBTL1, with low micro-molar to nanomolar Kd values (ITC)...
  11. Individual Predoctoral Dental Scientist Fellowship
    Ejvis Lamani; Fiscal Year: 2011
    ..The role of NFI-C in root formation first became evident when Nfi-c knockout mice presented with no molar root formation and severe incisor defects...
  12. GENETIC ANALYSIS OF THE MECHANISMS THAT REGULATE TOOTH MORPHOGENESIS
    GAIL ROBERTA MARTIN; Fiscal Year: 2010
    ..goals are: 1) study mice lacking either Spry2 or Spry4 function, in which tooth buds anterior to the first molar develop into supernumerary teeth. In wild-type mice, these buds regress to yield a toothless diastema region...
  13. Micromagnetic Aptamer PCR System for Ultrasensitive Multiplexed Protein Detection
    HYONGSOK TOM SOH; Fiscal Year: 2010
    ..higher than traditional ELISA technique), with a wide dynamic range spanning 6 orders of magnitude (femto molar to nanomolar concentrations)...
  14. Proteomic approaches to validate novel cardiac biomarkers for myocardial infarcti
    Sakthivel Sadayappan; Fiscal Year: 2013
    ..0-fold molar). However, verification and validation of the precise amount of plasma cMyBP-C is the next critical step...
  15. Load-mediated Adaptation of the Bone-PDL-Tooth Complex in Vertebrates
    Sunita P Ho; Fiscal Year: 2013
    ..Load-displacement curves and correlating strains fields in adapted complexes of 2nd molar from freshly harvested experimental groups and controls (as in Aim 1) will be evaluated and compared...
  16. Modeling human trophoblast stem cells using iPS cells derived from molar placenta
    Mana M Parast; Fiscal Year: 2013
    ..We therefore propose to take advantage of complete molar gestations, which, being exclusively of paternal origin, are unable to give rise to any embryonic tissue and ..
  17. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2012
    ..tissue (evaluating substance P (SP) release from neuron terminals innervating dental pulp from extracted third molar teeth)...
  18. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2009
    ..is the presence of overgrown maxillary incisors, lack of visible mandibular incisors and very short or absent molar roots. This phenotype indicates that the Nfi-c gene product is essential for the process of root formation...
  19. Molecular Patterning of Mammalian Dentition
    Rulang Jiang; Fiscal Year: 2013
    ..mice with neural crest specific inactivation of the Bmp4 gene exhibit developmental arrest of only the mandibular molar buds but their maxillary molars and incisors developed to mineralized teeth...
  20. Epidemiology of Dental Caries and Immunity in Children
    Noel K Childers; Fiscal Year: 2013
    ..e., adolescents, and emergence of permanent 2nd molar teeth) by continuing to follow these children and add an additional older cohort...
  21. Vitamin D3 Metabolism and Colorectal Cancer: Correlating Phenotype to Genotype
    Josephia R Muindi; Fiscal Year: 2011
    ..index of 25-D3, 24,25-D3 and 1,25-D3 levels (measured as free index of each vitamin D3 metabolite---defined as the molar ratio of the total serum metabolite/DBP)...
  22. Neurodegeneration in prion diseases: Therapy and diagnosis
    Claudio Soto; Fiscal Year: 2010
    ..Our results indicate that exposition of neuronal cells to nano-Molar concentrations of purified prPres leads to a two-phase response consisting of an initial protective cellular ..
  23. Does Anesthetic Solubility Determine Receptor Specificity?
    ROBERT JOSEPH BROSNAN; Fiscal Year: 2013
    ..preliminary data that suggest drug modulation of at least two anesthetic-sensitive receptors is predicted by a molar water solubility "cut-off" value...
  24. Sex Differences in Acute Pain and Analgesic Responses: Psychosocial and Genetic I
    Barbara A Hastie; Fiscal Year: 2010
    ..140 male and female patients (age range 16-45) who undergo third molar extraction will be included in this study...
  25. Functional Tooth Mobility
    Zi Jun Liu; Fiscal Year: 2013
    ..fluid pressure, we plan to examine the normal range of functional mobility of mesial roots of the maxillary first molar (Aim 1), and to assess how these physiological kinetics are affected by various degrees of alveolar bone loss (Aim ..
  26. Mechanisms of FoxJ1 Tooth Morphogenesis
    Brad A Amendt; Fiscal Year: 2012
    ..Our preliminary data reveals FoxJ1 expression in the mouse molar inner dental epithelium from E18.5 onwards and in the pre-ameloblasts and odontoblasts during neonate day 1...
  27. Molecular Regulation of Early Odontogenesis
    Richard L Maas; Fiscal Year: 2013
    ..we developed important new methods for reconstructing the gene regulatory network (GRN) that underlies early molar tooth formation, and we identified a unique E-M Wnt-Bmp4 feedback circuit that controls key steps in this process...
  28. High throughput screening of bacterial collections for surface proteins of commer
    Roy H Hammerstedt; Fiscal Year: 2010
    ..is particularly important when dealing with low concentrations of target ligands in complex mixtures with a large molar excess of irrelevant proteins, a current bottleneck for proteomic studies in most medical subspecialties...
  29. Joubert syndrome and related disorders of hindbrain development
    DANIEL A DOHERTY; Fiscal Year: 2013
    ..JSRD) are a group of autosomal recessive conditions characterized by a distinctive hindbrain malformation (the "molar tooth sign" - MTS) combined with intellectual disability (mental retardation), hypotonia, ataxia, and variably, ..
  30. Liposomal Recombinant Vaccine and Caries Immunity
    Noel K Childers; Fiscal Year: 2010
    ..for the oral pathogens mutans streptococci (MS) in infants occurs at 18-24 months of age, a time when primary molar teeth are erupting. It has been proposed that other "windows" open when susceptible teeth erupt, e.g...
  31. DMP1 Mutations: Defects in Odontogenesis
    Jian Q Feng; Fiscal Year: 2012
    ..with enlarged pulp chambers, increased width of the predentin zone, hypomineralization, and delayed 3rd molar formation...
  32. Calibrated ChIP-seq: determining local histone modification density genome-wide
    ALEXANDER JACKSON RUTHENBURG; Fiscal Year: 2013
    ..nucleosome positioning sequence that is flanked by a variable "barcode" that represents each member[unreadable]s molar concentration, then spiked into the input of a native ChIP-seq experiment...
  33. Regulation of PD-1 as a strategy against chronic HIV-1 infection
    Li Huang; Fiscal Year: 2013
    ..D9-1, could selectively suppress the PD-1 expression on human peripheral blood mononuclear cells at low micro molar concentrations without affecting T cell activation...
  34. Label-free optical imaging of 3D structural and functional microcirculations
    Ruikang Wang; Fiscal Year: 2012
    ..oxygenation status of the blood perfusion by a novel spectroscopic OMAG technique, which relies on the different molar extinction coefficients between the oxygenated and de- oxygenated hemoglobin in the near-infrared region at 800 nm ..
  35. Stress History is Recorded in Tooth Enamel
    SHANE NEWPORT WHITE; Fiscal Year: 2012
    ..We hypothesize that: Analysis of enamel in third molar teeth is a biomarker measure of a person's stress history from approximately 8 to 11 years of age...
  36. Molecular Characterization of Joubert Syndrome
    Joseph G Gleeson; Fiscal Year: 2013
    ..major subset of these conditions, consisting of a cerebellar midline (vermis) malformation, a nearly pathognomonic Molar Tooth sign on brain Imaging (MTI) and co-existent oculomotor apraxia and episodic breathing dysrhythmias...
  37. HUMAN ISLET ANTGEN DISCOVERY AND IMAGING
    Paul E Harris; Fiscal Year: 2012
    ..These dynamic measurements of specific radiolabled compounds are sensitive in the pico- to nano-molar range and can be deconvoluted into measurements of receptor concentration...
  38. Physiological roles of regulated changes in membrane phospholipid composition
    John May; Fiscal Year: 2012
    ..Nevertheless, environmental signals can induce changes in the molar ratio of anionic to zwitterionic phospholipids, raising questions about the physiological roles of regulated ..
  39. Mechanism of protein folding intermediate disaggregation by molecular chaperones
    Hays S Rye; Fiscal Year: 2013
    ..tool based on single-particle fluorescence burst detection that is capable of rapidly quantifying the specific molar distribution of states within an aggregated protein population, as well as how that distribution changes with time,..
  40. Etiologic and therapeutic studies of heparin-induced thrombocytopenia (HIT)
    Mortimer Poncz; Fiscal Year: 2011
    ..Over a narrow molar range of reactants: (1) PF4 and heparin form soluble antigenic ultralarge complexes (ULCs) and (2) PF4 and ..
  41. Function and regulation of Lhx genes in craniofacial development
    Juhee Jeong; Fiscal Year: 2013
    ..Specifically, I found that the Lhx genes are essential for the initial steps of molar and secondary palate development...
  42. Ethnic Differences in Acute Pain and Analgesic Response
    Barbara A Hastie; Fiscal Year: 2010
    ..200 African American and white adults (age range 18-55) who undergo third molar extraction will be included in this study...
  43. Computer-based Speech Practice for Dysarthria: A Preliminary Investigation
    SUSAN KATHERINE FAGER; Fiscal Year: 2013
    ..This study will utilize a three-level research design that includes molar (group analysis using a within subjects repeated measures ANOVA), intermediate, and molecular (individual detailed ..
  44. Safety and initial efficacy of lisdexamfetamine for methamphetamine dependence
    RAJKUMAR JYOTISHCHANDRA SEVAK; Fiscal Year: 2012
    ..A recent study of abuse liability showed that at doses of LDX and d- amphetamine that contain equivalent molar amounts of free amphetamine base, LDX produced significantly less "drug liking" than did d-amphetamine...
  45. Metabolomics approaches to TB drug development
    Kyu Y Rhee; Fiscal Year: 2010
    ..In vitro, RNI kill Mtb with a molar potency greater than that of many currently used TB drugs...
  46. Quantitative Proteomic Reconfiguration in Induction of Neuroprotection against St
    An Zhou; Fiscal Year: 2012
    ..We offer the following aims: Specific Aim 1. To establish in absolute molar numbers, the stoichiometry of proteins that comprise PcG/TrxG epigenetic regulator complexes at the onset of ..
  47. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 2002
    ..These include viscosity, colloid oncotic pressure, molecular weight and molar volume, and the influence of the type of modification (intramolecular versus surface)...
  48. SFG Investigation of Peptide and Protein Orientations in Membranes
    Zhan Chen; Fiscal Year: 2012
    ..Unique structural information of membrane peptides with a very low surface concentration (peptide-lipid molar ratio<1:5,000) can be characterized using DRSFG. 3...
  49. GLASS TRANSITION TEMPERATURE AND WEAR OF DENTAL RESINS
    JAN STANNARD; Fiscal Year: 1993
    Dental composites are subjected to abrasive action that can wear away the contact surface of a restored tooth. In molar teeth this problem is greatest where occlusal forces are maximum...
  50. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..In observational studies, high serum IGF-I, low serum IGFBP-3, or a high molar ratio of IGF-I relative to IGFBP-3 are associated with increased risk of breast, prostate, lung, and colon cancers,..
  51. Social and Academic Problems in ADHD: The Role of Implicit and Explicit Learning
    Cynthia L Huang-Pollock; Fiscal Year: 2013
    ..then psychotherapeutic and pharmacologic interventions should target processing speed (as opposed to the more molar EF process), which would have positive downstream implications for a number of higher order executive processes, ..
  52. PHOTOTUNABLE BIOMATERIALS TO ENGINEER COMPLEX 3D CELL MICROENVIRONMENTS
    ANDREA MARIE KASKO; Fiscal Year: 2011
    ..linkers based on a photolabile nitrobenzylether moiety, whose degradation rate is a function of wavelength, molar absorptivity, and light intensity...
  53. C/EBP Regulation of Dentinogenesis
    John Harrison; Fiscal Year: 2009
    ..showed evidence of dentin dysplasia occurring Preferentially on the lingual side of the incisors and in the molar roots. This was characterized by reduced thickness and disrupted tubular structure of the dentin...
  54. APOLIPOPROTEIN E BINDING TO RECEPTORS
    David Chappell; Fiscal Year: 1991
    ..current techniques, it is not possible to quantitate defects in lipoprotein receptor-ligand interactions on a molar basis in vivo...
  55. Miniature, rapid, and 3-dimensional OCT scanner for dental imaging
    GUANGHAI JIN; Fiscal Year: 2009
    ..information needed for early detection of decay and in imaging the occlusal, or biting surfaces of the rear or molar teeth, where up to 80% of all tooth decay originates...
  56. Optimization of DIACEST and PARACEST methodology for quantitative in-vivo imaging
    Elena Vinogradov; Fiscal Year: 2010
    ..First, CEST provides an amplification mechanism, allowing detection of metabolites present in the micro- to milli- Molar concentration ranges, normally inaccessible for MRI...
  57. GROWTH FACTOR RECEPTOR TARGETED TOXINS FOR LEUKEMIA
    John Murphy; Fiscal Year: 1992
    ..transformed human T-cell lines which bear the high affinity IL-2 receptor, so far tested, are killed by pico molar concentrations of IL-2-toxin; whereas receptor negative cells are resistant to the action of this chimeric toxin...
  58. Cellular and Molecular Determinants of Tooth Eruption
    Hitesh Kapadia; Fiscal Year: 2005
    ..patterns of Cbfa1 mRNA and protein expression in dental follicle cells during all phases of first mandibular molar eruption using molecular and immunochemical methods...
  59. Immune Recognition of Modified Antigen in Scleroderma
    Robert Hoffman; Fiscal Year: 2003
    ..Specificity will be determined in blocking studies using molar excess of either intact, apoptotic 70k or oxidative modified 70k pre-incubated prior to immunoblotting...
  60. DEVELOPMENT OF CANCER IMAGING AGENTS
    Henry VanBrocklin; Fiscal Year: 2000
    ..A series of aminoquinazoline derivatives, structurally similar to those know to inhibit EGFRtk at pico- to nano- molar concentration suitable for labeling with fluorine-18, carbon-11, bromine-76 or iodine-123 will be synthesized...
  61. Asymmetric flow FFF and Composition Gradient/Light Scattering System
    Ewa Folta Stogniew; Fiscal Year: 2007
    ..step and light scattering (LS) as a detection method allows sample fractionation and determination of size and molar mass in a single experiment: the molar mass is determined from a static LS measurement and the hydrodynamic radius ..
  62. Site-Specific Non-Mutans Streptococci Etiologies of Dental Caries
    Jeffrey A Banas; Fiscal Year: 2013
    ..We propose to: 1) Isolate non-MS strains of primary colonizing streptococci from second molar occulsal samples, determine the diversity of genotypes present, and the diversity of acid-related phenotypes for ..
  63. Quantum Dots and Magnetic Nanoparticles for Ante-mortem Diagnosis of Prion Infect
    ZORAIDA AGUILAR; Fiscal Year: 2009
    ..The dLOAC is configured for ante-mortem diagnosis of 1 x 10-15 molar (possibly 1 x 10-18molar) concentrations of PrPSc in a rapid assay d 60 min, high throughput allowing >50 ..
  64. THE HYRAX AS A MODEL FOR FACIAL BIOMECHANICS AND GROWTH
    Marisa St Claire; Fiscal Year: 2000
    ..Dental crowding (especially third molar impactions) and certain malocclusions partially result from inadequate mechanical stimuli to the mandibular and ..
  65. DENTIN SPECIFIC PHOSPHOPROTEINS AND MINERALIZATION
    Mary Macdougall; Fiscal Year: 2000
    ..This will be accomplished by construction and screening of a mouse molar cDNA library...
  66. Fatigue of Restorative Ceramics
    Jason A Griggs; Fiscal Year: 2010
    ..324 N in humans, and finite element models have predicted these loads to induce stresses of 22 to 87 MPa in molar crowns. Traditional dental ceramics can withstand 11...
  67. ANGIOTENSIN II & HYPERTENSION
    Kevin Lynch; Fiscal Year: 1990
    ..Unlike classical peptide euromodulators, the prohormone angiotensinogen is reportedly found at 100-fold molar excess over the active hormone, angiotensin II (Ang II), is present extracellularly and may be synthesized by glia ..