dental pellicle

Summary

Summary: A thin protein film on the surface of DENTAL ENAMEL. It is widely believed to result from the selective adsorption of precursor proteins present in SALIVA onto tooth surfaces, and to reduce microbial adherence to the TEETH.

Top Publications

  1. ncbi Roles of salivary proteins in the adherence of oral streptococci to various orthodontic brackets
    S J Ahn
    Department of Orthodontics, College of Dentistry, Seoul National University, 28 22 Yunkeun Dong, ChongRo Ku, Seoul 110 744, Korea, ROK
    J Dent Res 81:411-5. 2002
  2. ncbi Statherin and histatin 1 reduce parotid saliva-promoted Streptococcus mutans strain MT8148 adhesion to hydroxyapatite surfaces
    A Shimotoyodome
    Biological Science Laboratories, Tokyo, Japan
    Caries Res 40:403-11. 2006
  3. ncbi Electron-microscopic demonstration of proline-rich proteins, statherin, and histatins in acquired enamel pellicles in vitro
    P Schupbach
    Institute of Oral Microbiology and General Immunology, University of Zurich, Switzerland
    Eur J Oral Sci 109:60-8. 2001
  4. ncbi Actinomyces naeslundii in initial dental biofilm formation
    I Dige
    Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, Aarhus University, Vennelyst Boulevard 9, 8000 Aarhus C, Denmark
    Microbiology 155:2116-26. 2009
  5. ncbi Peptidomic analysis of human acquired enamel pellicle
    Rui Vitorino
    Department of Chemistry, University of Aveiro, Aveiro, Portugal
    Biomed Chromatogr 21:1107-17. 2007
  6. pmc Small molecular weight proteins/peptides present in the in vivo formed human acquired enamel pellicle
    Walter L Siqueira
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston University, 700 Albany Street, CABR, W201, Boston, MA 02118, United States
    Arch Oral Biol 54:437-44. 2009
  7. ncbi Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins
    I Iontcheva
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Dent Res 76:734-43. 1997
  8. ncbi Acquired enamel pellicle and its potential role in oral diagnostics
    W L Siqueira
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Ann N Y Acad Sci 1098:504-9. 2007
  9. ncbi Salivary proteins promote proteolytic activity in Streptococcus mitis biovar 2 and Streptococcus mutans
    C Kindblom
    Department of Oral Biology, Faculty of Odontology, Malmo University, Malmo, Sweden
    Mol Oral Microbiol 27:362-72. 2012
  10. ncbi New insights into the composition and functions of the acquired enamel pellicle
    W L Siqueira
    School of Dentistry and Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
    J Dent Res 91:1110-8. 2012

Research Grants

Detail Information

Publications151 found, 100 shown here

  1. ncbi Roles of salivary proteins in the adherence of oral streptococci to various orthodontic brackets
    S J Ahn
    Department of Orthodontics, College of Dentistry, Seoul National University, 28 22 Yunkeun Dong, ChongRo Ku, Seoul 110 744, Korea, ROK
    J Dent Res 81:411-5. 2002
    ..However, salivary pellicles decreased the binding of S. mutans. Collectively, salivary pellicles were found to play a significant role in the initial adhesion of oral streptococci to orthodontic brackets...
  2. ncbi Statherin and histatin 1 reduce parotid saliva-promoted Streptococcus mutans strain MT8148 adhesion to hydroxyapatite surfaces
    A Shimotoyodome
    Biological Science Laboratories, Tokyo, Japan
    Caries Res 40:403-11. 2006
    ..mutans adhesion promoted by parotid saliva. We conclude that ST and HT1 competitively inhibit the adsorption of salivary HMWGP, and thereby reduce S. mutans adhesion onto HA surfaces...
  3. ncbi Electron-microscopic demonstration of proline-rich proteins, statherin, and histatins in acquired enamel pellicles in vitro
    P Schupbach
    Institute of Oral Microbiology and General Immunology, University of Zurich, Switzerland
    Eur J Oral Sci 109:60-8. 2001
    ....
  4. ncbi Actinomyces naeslundii in initial dental biofilm formation
    I Dige
    Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, Aarhus University, Vennelyst Boulevard 9, 8000 Aarhus C, Denmark
    Microbiology 155:2116-26. 2009
    ..The participation of A. naeslundii in the initial stages of dental biofilm formation may have important ecological consequences...
  5. ncbi Peptidomic analysis of human acquired enamel pellicle
    Rui Vitorino
    Department of Chemistry, University of Aveiro, Aveiro, Portugal
    Biomed Chromatogr 21:1107-17. 2007
    ..In the case of acidic proline-rich proteins, a clearly predominance of cleavage of the Gln-Gly amide bond was evident...
  6. pmc Small molecular weight proteins/peptides present in the in vivo formed human acquired enamel pellicle
    Walter L Siqueira
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston University, 700 Albany Street, CABR, W201, Boston, MA 02118, United States
    Arch Oral Biol 54:437-44. 2009
    ..The aim of this study was to investigate the type and the nature of peptides present in the in vivo formed human acquired enamel pellicle...
  7. ncbi Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins
    I Iontcheva
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Dent Res 76:734-43. 1997
    ....
  8. ncbi Acquired enamel pellicle and its potential role in oral diagnostics
    W L Siqueira
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Ann N Y Acad Sci 1098:504-9. 2007
    ..Recent developments in both pellicle collection methods and nanoscale sensing technologies have brought the exploitation of pellicle analysis into the realm of point-of-care oral diagnostics...
  9. ncbi Salivary proteins promote proteolytic activity in Streptococcus mitis biovar 2 and Streptococcus mutans
    C Kindblom
    Department of Oral Biology, Faculty of Odontology, Malmo University, Malmo, Sweden
    Mol Oral Microbiol 27:362-72. 2012
    ..mitis biovar 2 and S. mutans...
  10. ncbi New insights into the composition and functions of the acquired enamel pellicle
    W L Siqueira
    School of Dentistry and Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
    J Dent Res 91:1110-8. 2012
    ....
  11. ncbi Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS
    Walter L Siqueira
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Proteome Res 6:2152-60. 2007
    ..A high intersubject consistency in pellicle composition was observed...
  12. ncbi Salivary flow patterns and the health of hard and soft oral tissues
    Colin Dawes
    Department of Oral Biology, Faculty of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Manitoba, Canada
    J Am Dent Assoc 139:18S-24S. 2008
    ..This nonsystematic review summarizes the effects of saliva on some of the diseases affecting the hard and soft oral tissues...
  13. ncbi Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches
    Yuan Yao
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:5300-8. 2003
    ..MS approaches allowed identification of not only well characterized salivary proteins but also novel proteins not previously identified in pellicle...
  14. ncbi Histatin 1 resists proteolytic degradation when adsorbed to hydroxyapatite
    E E McDonald
    School of Dentistry, Dental Sciences Building DSB0071, Schulich School of Medicine and Dentistry, The University of Western Ontario, London N6A 5C1, ON, Canada
    J Dent Res 90:268-72. 2011
    ..This study shows for the first time that binding to hydroxyapatite confers intact histatin 1 with resistance to proteolytic degradation...
  15. ncbi Enzymes in the acquired enamel pellicle
    Christian Hannig
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Eur J Oral Sci 113:2-13. 2005
    ..This review summarizes the present state of research on enzymes and their functions in the dental pellicle. Theoretically, all enzymes present in the oral cavity could be incorporated into the pellicle, but ..
  16. ncbi Compositional analysis of human acquired enamel pellicle by mass spectrometry
    Y Yao
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 700 Albany Street, Suite W201, Boston, MA 02118, USA
    Arch Oral Biol 46:293-303. 2001
    ..Unique features of the oral environment such as enzymatic activities or mineral surface properties may account for these differences between in vivo and in vitro pellicle formation...
  17. ncbi Identification of in vivo pellicle constituents by analysis of serum immune responses
    J Li
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 700 Albany Street, Boston, MA 02118, USA
    J Dent Res 83:60-4. 2004
    ..The polyclonal antibody approach provided a powerful method for the identification of various pellicle proteins, including some which show mineral homeostasis or antimicrobial activity...
  18. ncbi Peptide profile of human acquired enamel pellicle using MALDI tandem MS
    Rui Vitorino
    Department of Chemistry, University of Aveiro, Aveiro, Portugal
    J Sep Sci 31:523-37. 2008
    ..Fragments present in the AEP show a predominance of cleavage points located at Arg, Tyr and Lys residues. Obtained data suggest that proteolytic activity could influence AEP formation and composition...
  19. ncbi Intrinsic enzymatic crosslinking and maturation of the in situ pellicle
    C Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Street 55, D 79106 Freiburg, Germany
    Arch Oral Biol 53:416-22. 2008
    ..It has been supposed that the pellicle undergoes maturation after protein adsorption. The aim of the present study was to investigate enzyme activities with an impact on intrinsic maturation processes in in situ formed pellicles...
  20. ncbi The structure, function and properties of the acquired pellicle
    M Hannig
    Department of Operative Dentistry and Periodontology, Saarland University, Universitatskliniken des Saarlandes, Geb 73, DE 66421 Homburg Saar, Germany
    Monogr Oral Sci 19:29-64. 2006
  21. ncbi Influence of dentifrices and dietary components in saliva on wettability of pellicle-coated enamel in vitro and in vivo
    H C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 110:434-8. 2002
    ....
  22. ncbi Salivary proteins: protective and diagnostic value in cariology?
    A van Nieuw Amerongen
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands a van_nieuw_
    Caries Res 38:247-53. 2004
    ..These are potentially suited as templates for the design of a new generation of antibiotics, since they kill a broad spectrum of microorganisms, while hardly evoking resistance, in contrast to the classical antibiotics...
  23. ncbi Protective effect of the in situ pellicle on dentin erosion - an ex vivo pilot study
    Christian Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Arch Oral Biol 52:444-9. 2007
    ..The aim of the present ex vivo study was to evaluate the erosive effects on pellicle coated dentin...
  24. ncbi Identification of early microbial colonizers in human dental biofilm
    J Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Appl Microbiol 97:1311-8. 2004
    ..To elucidate the first colonizers within in vivo dental biofilm and to establish potential population shifts that occur during the early phases of biofilm formation...
  25. ncbi Protective effect of the dental pellicle against erosive challenges in situ
    A T Hara
    Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Dent Res 85:612-6. 2006
    The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour pellicle protects against different erosive challenges by orange juice...
  26. ncbi Exposure time of enamel and dentine to saliva for protection against erosion: a study in vitro
    S Wetton
    Division of Restorative Dentistry, University of Bristol, Dental School, Bristol, UK
    Caries Res 40:213-7. 2006
    ..Cautiously extrapolating these in vitro data suggests that pellicle should offer erosion protection to individuals who imbibe acidic drinks at frequencies of 1 h or less...
  27. ncbi The protective nature of pellicle towards toothpaste abrasion on enamel and dentine
    Andrew Joiner
    Unilever Oral Care, Quarry Road East, Bebington, Wirral CH63 3JW, United Kingdom
    J Dent 36:360-8. 2008
    ..To determine the protective nature of pellicle towards toothpaste abrasion...
  28. pmc Evidence of intact histatins in the in vivo acquired enamel pellicle
    W L Siqueira
    Schulich Dentistry and Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada
    J Dent Res 89:626-30. 2010
    ..The in vitro experiments show that all naturally occurring histatins in the AEP have the potential to provide some level of protection against acid injury...
  29. ncbi Protective properties of salivary pellicles from two different intraoral sites on enamel erosion
    M Hannig
    Department of Operative Dentistry and Periodontology, Albert Ludwigs University, Freiburg, Germany
    Caries Res 35:142-8. 2001
    ..In conclusion, site-dependent differences of buccally and lingually in vivo formed 24-hour pellicles have minor importance concerning the pellicle-induced protection of the enamel surface against erosive changes...
  30. ncbi Hexametaphosphate effects on tooth surface conditioning film chemistry--in vitro and in vivo studies
    Henk J Busscher
    University of Groningen, Department of Biomedical Engineering, Groningen, The Netherlands
    J Clin Dent 13:38-43. 2002
    ..These surface chemistries may contribute to the unique clinical actions of hexametaphosphate established in recently reported, randomized clinical studies of tartar control, stain prevention and stain removal effects...
  31. ncbi Effects of Cistus-tea on bacterial colonization and enzyme activities of the in situ pellicle
    Christian Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    J Dent 36:540-5. 2008
    ..Polyphenols are expected to have antibacterial properties. Cistus is a tea rich in polyphenols. The aim of the present in situ study was to investigate the effect of Cistus-tea on the pellicle and on the initial oral biofilm...
  32. ncbi Action of agents on glucosyltransferases from Streptococcus mutans in solution and adsorbed to experimental pellicle
    D Wunder
    University of Rochester, Center for Oral Biology, NY 14642, USA
    Arch Oral Biol 44:203-14. 1999
    ..These data indicate that the nature of the inhibitor is important, and also whether the Gtf enzyme is in solution or adsorbed to saliva-coated hydroxylapatite...
  33. ncbi Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatite
    H Koo
    Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, Brazil
    Caries Res 34:418-26. 2000
    ..There is a need to identify the active compounds of propolis...
  34. pmc Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface
    Kiran S Ambatipudi
    Departments of Pharmacology and Physiology, Rochester Proteomics Center, University of Rochester Medical Center, Rochester, New York 14642, United States
    J Proteome Res 9:6605-14. 2010
    ..Thus, our data demonstrate that the host salivary protein CSP-1 binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface...
  35. ncbi Electron microscopic detection and activity of glucosyltransferase B, C, and D in the in situ formed pellicle
    C Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Arch Oral Biol 53:1003-10. 2008
    ..Glucosyltransferases (GTFs) represent a virulence factor of mutans streptococci. The aim of the present in situ study was to investigate the distribution of different GTF-isoforms in the pellicle...
  36. ncbi Sequence of oral bacterial co-adhesion and non-contact brushing
    H C van der Mei
    Department of Biomedical Engineering, University Medical Center Groningen, and University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent Res 86:421-5. 2007
    ..At contact, rotary and sonic brushing performed equally well in bacterial removal, while at 4 mm, both had lost some efficacy...
  37. ncbi Influence of weight on removal of co-adhering bacteria from salivary pellicles by different modes of brushing
    H C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Caries Res 38:85-90. 2004
    ....
  38. ncbi Salivary receptors for the proline-rich protein-binding and lectin-like adhesins of oral actinomyces and streptococci
    S Ruhl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Building 30, Room 532, National Institutes of Health, Bethesda, MD 20892, USA
    J Dent Res 83:505-10. 2004
    ..These findings suggest the involvement of specific adhesins in bacterial recognition of many adsorbed salivary proteins and glycoproteins...
  39. ncbi Enamel erosion in dietary acids: inhibition by food proteins in vitro
    C A Hemingway
    Department of Oral and Dental Science, University of Bristol, Bristol, UK
    Caries Res 44:525-30. 2010
    ..The citrate ion may play an active stabilising role, since erosion reduction was less in the other acids. In conclusion, casein and, to a lesser extent, ovalbumin show promise as potential anti-erosive additives to drinks...
  40. ncbi Efficacy and mechanisms of non-antibacterial, chemical plaque control by dentifrices--an in vitro study
    Henk J Busscher
    Department of Biomedical Engineering, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent 35:294-301. 2007
    ..It is the aim of this paper to analyze in vitro detachment of co-aggregating oral actinomyces and streptococci from pellicle surfaces by dentifrice supernates and to study subsequent de novo streptococcal deposition...
  41. ncbi Adsorption of salivary and serum proteins, and bacterial adherence on titanium and zirconia ceramic surfaces
    Emilena Maria Castor Xisto Lima
    Department of Prosthodontics and Periodontology, Faculty of Dentistry of Piracicaba, University of Campinas, Piracicaba, SP, Brazil
    Clin Oral Implants Res 19:780-5. 2008
    ..In addition, the protein profiles and bacterial binding properties of pellicles on Ti and ZrO(2) were compared to those formed on hydroxyapatite (HA) surface...
  42. ncbi Impact of the in situ formed salivary pellicle on enamel and dentine erosion induced by different acids
    Annette Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Zurich, Switzerland
    Acta Odontol Scand 66:225-30. 2008
    ..To investigate and compare the protective impact of the in situ formed salivary pellicle on enamel and dentine erosion caused by different acids at pH 2.6...
  43. ncbi Moderation of oral bacterial adhesion on saliva-coated hydroxyapatite by polyaspartate
    Y H Guan
    University of Sheffield and Boots National Centre for Applied Research into Oral Health, and Department of Oral Health and Development, School of Clinical Dentistry, Sheffield S10 2TA, UK
    J Appl Microbiol 94:456-61. 2003
    ..Synthetic sodium alpha,beta-polyaspartate (PA) has been investigated as a moderator of adhesion and the subsequent biofilm formation by oral bacteria...
  44. ncbi Surfactive and antibacterial activity of cetylpyridinium chloride formulations in vitro and in vivo
    Henk J Busscher
    Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Clin Periodontol 35:547-54. 2008
    ..To compare effects of three cetylpyridinium chloride (CPC) formulations with and without alcohol and Tween80 on physico-chemical properties of salivary pellicles, bacterial detachment in vitro and bacterial killing in vivo...
  45. ncbi Effects of amine fluoride on biofilm growth and salivary pellicles
    H C van der Mei
    Department of Biomedical Engineering, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Caries Res 42:19-27. 2008
    ..The major effect of AmF treatment, however, was a reduction brought about in biofilm viability...
  46. ncbi Non-contact removal of coadhering and non-coadhering bacterial pairs from pellicle surfaces by sonic brushing and de novo adhesion
    H J Busscher
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 111:459-64. 2003
    ..However, non-contact, sonic brushing with only a thin wet film on the substratum may leave footprints to which streptococci preferentially adhere...
  47. ncbi Characterization of the immunologic responses to human in vivo acquired enamel pellicle as a novel means to investigate its composition
    J Li
    Department of Periodontology, Boston University Goldman School of Dental Medicine, Boston, MA, USA
    Oral Microbiol Immunol 18:183-91. 2003
    ..The results open up the possibility that immunization with human pellicle and mAbs production can be employed to identify hitherto unknown constituents of pellicle...
  48. ncbi Pathogenesis and modifying factors of dental erosion
    J H Meurman
    Faculty of Dentistry, University of Kuopio, Finland
    Eur J Oral Sci 104:199-206. 1996
    ..Neither is there consensus as to how effective fluorides are in preventing the progression of erosive lesions, or how the chemical and structural factors of tooth tissue in general might modify this pathological process...
  49. ncbi The effects of milk and kappa-casein on salivary pellicle formed on hydroxyapatite discs in situ
    A M Vacca Smith
    Center of Oral Biology, University of Rochester, N Y 14642, USA
    Caries Res 34:88-93. 2000
    ..These data suggest that milk and kappa-casein may influence pellicle formation in vivo...
  50. ncbi In situ studies of pellicle formation on hydroxyapatite discs
    A M Vacca Smith
    Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Arch Oral Biol 45:277-91. 2000
    ..It is apparent that this in situ model could be used in screening potential antiplaque agents...
  51. ncbi Protective effect of the in situ formed short-term salivary pellicle
    Matthias Hannig
    Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospitals, Building 73, D 66421 Homburg Saar, Germany
    Arch Oral Biol 49:903-10. 2004
    ..However, pellicle does not completely inhibit the erosive action of citric acid under the conditions of the present study...
  52. ncbi Microbubble-induced detachment of coadhering oral bacteria from salivary pellicles
    Prashant K Sharma
    Department of Biomedical Engineering, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 113:326-32. 2005
    ..naeslundii on the pellicle surface, providing nucleation sites for the de novo adhesion of coadhering streptococci...
  53. ncbi In vitro inhibition of oral streptococci binding to the acquired pellicle by algal lectins
    E H Teixeira
    Faculdade de Medicina de Sobral, Universidade Federal do Ceara, Fortaleza CE, Brazil
    J Appl Microbiol 103:1001-6. 2007
    ..This work aimed to evaluate the potential of two algal lectins to inhibit the adherence of five streptococci species to the acquired pellicle in vitro...
  54. ncbi Adhesion of salivary components to Streptococcus mutans peptides
    Jairo A Tovar
    Dental Research Center, School of Dentistry, Javeriana University, Bogota, Colombia
    Acta Odontol Latinoam 19:53-8. 2006
    ..This suggests that the examined PAc's are not relevant as far as the initial adhesion of Streptococcus mutans to the tooth's surface is concerned, as defined by the similarities in the results for healthy and affected individuals...
  55. ncbi Influence of biosurfactant on interactive forces between mutans Streptococci and enamel measured by atomic force microscopy
    C G van Hoogmoed
    Department of Biomedical Engineering, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent Res 85:54-8. 2006
    ..These findings indicate that adsorbed S. mitis BMS biosurfactant changes the interactive forces between the mutans streptococci studied and enamel, explaining the effects of biosurfactant on adhesion...
  56. ncbi Multi-component adsorption model for pellicle formation: the influence of salivary proteins and non-salivary phospho proteins on the binding of histatin 5 onto hydroxyapatite
    A Yin
    Department of Periodontology and Oral Biology, Boston University Medical Center, 700 Albany Street, Suite W201, Boston, MA 02118, USA
    Arch Oral Biol 51:102-10. 2006
    ..These data suggest that specific protein-protein interactions may play important roles in pellicle formation in vivo...
  57. ncbi Adhesion of oral streptococci to all-ceramics dental restorative materials in vitro
    R Meier
    Institute of Preventive Dentistry and Oral Microbiology, Dental School, University of Basel, Hebelstrasse 3, 4056 Basel, Switzerland
    J Mater Sci Mater Med 19:3249-53. 2008
    ..This presented in vitro technique may provide a useful model to study the influence of different parameters on adherence of oral streptococcal species...
  58. ncbi Immediate erosive potential of cola drinks and orange juices
    T Jensdottir
    Department of Oral Medicine, School of Dentistry, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
    J Dent Res 85:226-30. 2006
    ..However, salivary proteins reduced the erosive potential of cola drinks by up to 50%...
  59. ncbi Understanding the chemistry of dental erosion
    J D B Featherstone
    Department of Preventive and Restorative Dental Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Monogr Oral Sci 20:66-76. 2006
    ..Values of the strength of acid (pKa) and for the anion-calcium interaction and the mechanisms of interaction with the tooth mineral on the surface and underneath are described in detail...
  60. ncbi Biological factors
    Anderson T Hara
    Department of Preventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis, IN 46202 2876, USA
    Monogr Oral Sci 20:88-99. 2006
    Biological factors such as saliva, acquired dental pellicle, tooth structure and positioning in relation to soft tissues and tongue are related to dental erosion development...
  61. ncbi Saliva-promoted adhesion of Streptococcus mutans MT8148 associates with dental plaque and caries experience
    A Shimotoyodome
    Biological Science Laboratories, Tochigi, Japan
    Caries Res 41:212-8. 2007
    ..In conclusion, the present findings suggest the initial S. mutans adhesion, modulated by salivary protein adsorption onto the enamel surface, as a possible correlate of susceptibility to dental plaque and caries...
  62. ncbi Adsorption of chlorhexidine and black tea onto in vitro salivary pellicles, as studied by ellipsometry
    Andrew Joiner
    Unilever Oral Care, Port Sunlight Laboratory, Wirral, Merseyside, UK
    Eur J Oral Sci 114:337-42. 2006
    ..Thus, following exposure to chlorhexidine, the accelerated adsorption of salivary and black tea components can ultimately lead to increased staining of the pellicle...
  63. ncbi Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro
    A Haukioja
    Institute of Dentistry, University of Turku, Turku, Finland
    Oral Microbiol Immunol 21:326-32. 2006
    ..Our aim was to evaluate the oral colonization potential of different probiotic, dairy, and fecal Lactobacillus and Bifidobacterium strains in vitro...
  64. ncbi [Saliva as a main component of oral cavity ecosystem. Part II. Defense mechanisms]
    Anna K Jankowska
    Zakładu Stomatologii Dzieciqcej, Akademii Medycznej w Białymstoku
    Wiad Lek 60:253-7. 2007
    ..Some proteins of innate defense system have bactericidal or bacteriostatic effects; some can cause aggregation of oral bacteria resulting in their increased clearance from oral cavity...
  65. ncbi Adhesion of Streptococcus mutans to different types of brackets
    William Papaioannou
    Department of Preventive and Community Dentistry, University of Athens Dental School, Athens, Greece
    Angle Orthod 77:1090-5. 2007
    ..To examine the difference in the adhesion of Streptococcus mutans to three different types of orthodontic brackets and the effect of the presence of an early salivary pellicle and Streptococcus sanguis on adhesion...
  66. ncbi Influence of oral detergents and chlorhexidine on soft-layer electrokinetic parameters of the acquired enamel pellicle
    H J Busscher
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Caries Res 37:431-6. 2003
    ....
  67. ncbi Maintaining the integrity of the enamel surface: the role of dental biofilm, saliva and preventive agents in enamel demineralization and remineralization
    Franklin Garcia-Godoy
    Bioscience Research Center, College of Dental Medicine, Nova Southeastern University, 3200 S University Drive, Fort Lauderdale, FL 33328, USA
    J Am Dent Assoc 139:25S-34S. 2008
    ..Dental caries is an infectious disease, and it affects 90 percent of late adolescents and young adults in the United States. It is a complex disease that occurs along the interface between the dental biofilm and the enamel surface...
  68. ncbi Real-time interaction of oral streptococci with human salivary components
    M Kawashima
    Department of Cariology and Operative Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 18:220-5. 2003
    ..mutans was 2 times higher in than S. mitis (3.8) and slightly higher than S. sanguis (7.2). These findings may provide useful information regarding the mechanism of early biofilm formation by streptococci on the tooth surface...
  69. ncbi Protective effect of different tetrafluorides on erosion of pellicle-free and pellicle-covered enamel and dentine
    A Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Zurich, Switzerland
    Caries Res 42:247-54. 2008
    ..Tetrafluoride solutions, especially 1% TiF(4), could decrease dental erosion, but were more effective on dentine than on enamel...
  70. ncbi The anti-adherence effect of Piper betle and Psidium guajava extracts on the adhesion of early settlers in dental plaque to saliva-coated glass surfaces
    Fathilah Abdul Razak
    Department of Oral Biology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
    J Oral Sci 45:201-6. 2003
    ..It is therefore suggested that the plant extracts, in expressing their anti-adherence activities, could have altered the hydrophobic nature of the bonding between the bacteria and the saliva-coated glass surfaces...
  71. ncbi Bacteria-binding plasma proteins in pellicles formed on hydroxyapatite in vitro and on teeth in vivo
    A Carlen
    Department of Oral Microbiology, Institute of Odontology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Oral Microbiol Immunol 18:203-7. 2003
    Previous studies on dental pellicle formation and bacterial adherence have focussed on saliva and its components. The tooth surface is, however, also exposed to the plasma-derived crevicular fluid. In the present study, (i)...
  72. ncbi [Non mucin proteins of saliva with high homology of polypeptide chains]
    A Zalewska

    Postepy Hig Med Dosw 55:733-54. 2001
    ..Most of them are able to inhibit the formation of dental calculus and control the calcium phosphate homeostasis...
  73. ncbi Adsorption of parotid saliva proteins and adhesion of Streptococcus mutans ATCC 21752 to dental fiber-reinforced composites
    Johanna Tanner
    Institute of Dentistry and Biomaterials Research, University of Turku, Finland
    J Biomed Mater Res B Appl Biomater 66:391-8. 2003
    ..Higher quantities of S. mutans binding proteins in the pellicles may in part account for the higher S. mutans adhesion to saliva-coated ceramic and polyethylene FRC...
  74. ncbi Bacterial detachment from salivary conditioning films by dentifrice supernates
    Henny C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    J Clin Dent 13:44-9. 2002
    ....
  75. ncbi Assessment of enamel erosion and protective effect of salivary pellicle by surface roughness analysis and scanning electron microscopy
    Yuriy Nekrashevych
    Department of Periodontology and Conservative Dentistry, Saarland University, Homburg, Germany
    Oral Health Prev Dent 2:5-11. 2004
    ..To assess dental erosion caused by 0.1% and 1.0% citric acid in vitro and to estimate the protective influence of experimentally formed salivary pellicle...
  76. ncbi [The effects of traditional Chinese medicines on the adherence of Streptococcus mutans to salivary acquired pellicle in vitro]
    Zhengwei Huang
    West China School of Stomatology, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 34:135-7. 2003
    ..To investigate the effects of traditional Chinese medicines on the preliminary adherence of Streptococcus mutans to salivary acquired pellicles...
  77. ncbi Ellipsometry analysis of the in vitro adsorption of tea polyphenols onto salivary pellicles
    Andrew Joiner
    Unilever Oral Care, Port Sunlight Laboratory, Quarry Road East, Bebington, Wirral, Merseyside CH63 3JW, UK
    Eur J Oral Sci 112:510-5. 2004
    ..Therefore, black tea and its polyphenol components are indicated to have a profound effect on in vitro pellicle modification. Similar effects were observed for tannic acid...
  78. ncbi Electron microscopic detection of salivary alpha-amylase in the pellicle formed in situ
    Daniela Deimling
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetterstr 55, D 79106 Freiburg, Germany
    Eur J Oral Sci 112:503-9. 2004
    ..It could be concluded that alpha-amylase might act as a receptor for bacterial adherence to the pellicle in vivo...
  79. ncbi Sites of dental erosion are saliva-dependent
    W G Young
    School of Dentistry, The University of Queensland, Brisbane, Queensland, Australia
    J Oral Rehabil 29:35-43. 2002
    ....
  80. ncbi [The effects of natural medicine on adherence of Streptococcus mutans to salivary acquired pellicle]
    Yue Xiao
    West China School of Stomatology, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 35:687-9. 2004
    ..To investigate the effects of 5 kinds of natural medicine such as Radix et Rhizoma Rhei on the adherence of Streptococcus mutans to salivary acquired pellicle, and to screen effective natural medicines for the prevention of caries...
  81. ncbi Probiotic bacteria affect the composition of salivary pellicle and streptococcal adhesion in vitro
    A Haukioja
    Postgraduate School of Oral Health Sciences, Institute of Dentistry, Universeity of Turku, Turku, Finland
    Oral Microbiol Immunol 23:336-43. 2008
    ..The aim of this study was to investigate in vitro if the probiotic bacteria used in commercial products affect the protein composition of the salivary pellicle and the adherence of other oral bacteria...
  82. ncbi Experiments on in vivo biofilm formation and in vitro adhesion of Candida species on polysiloxane liners
    Mustafa Murat Mutluay
    Department of Prosthodontics, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Gerodontology 27:283-91. 2010
    ..Microorganisms may colonise polysiloxane soft liners leading to bio-deterioration. The aim of this study was to investigate in vitro adhesion and in vivo biofilm formation of Candida species on polysiloxane surfaces...
  83. pmc Erosion--diagnosis and risk factors
    A Lussi
    Department of Preventive, Restorative and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, CH 3010, Bern, Switzerland
    Clin Oral Investig 12:S5-13. 2008
    ..The clinical examination has to be done systematically, and a comprehensive case history should be undertaken such that all risk factors will be revealed...
  84. ncbi Effect of material characteristics and/or surface topography on biofilm development
    Wim Teughels
    Department of Periodontology, Faculty of Medicine, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Leuven, Belgium
    Clin Oral Implants Res 17:68-81. 2006
    ..An uncontrolled accumulation and/or metabolism of bacteria on the hard surfaces forms, however, the primary cause of dental caries, gingivitis, periodontitis, peri-implantitis, and stomatitis...
  85. ncbi Effects of human milk on adhesion of Streptococcus mutans to saliva-coated hydroxyapatite in vitro
    J Wernersson
    Department of Odontology Cariolog, Umea University, Umea, Sweden
    Caries Res 40:412-7. 2006
    ..Phenotypic variations in milk and saliva glycosylation may explain the inhibitory capacity and possibly affect susceptibility to colonization by S. mutans in childhood...
  86. ncbi The cariogenic dental biofilm: good, bad or just something to control?
    Mark Steven Wolff
    Department of Cariology and Comprehensive Care, College of Dentistry, New York University, New York, NY 10010, USA
    Braz Oral Res 23:31-8. 2009
    ..Optimal management of cavitations requires early detection. This, coupled with advances in adhesive restorative materials and microsurgical technique, will allow the tooth to be restored with minimal destruction to nearby healthy tissue...
  87. ncbi An in vitro study on the anti-adherence effect of Brucea javanica and Piper betle extracts towards oral Candida
    Mohd Al Faisal Nordin
    Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Arch Oral Biol 58:1335-42. 2013
    ..The adherence of Candida to mucosal surfaces is the initial step for successful invasive process of the oral cavity. The study aimed to investigate the effect of two plant extracts on the non-specific and specific bindings of oral candida...
  88. ncbi Erosion--chemical and biological factors of importance to the dental practitioner
    Domenick T Zero
    Department of Preventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis 46202, USA
    Int Dent J 55:285-90. 2005
    ..Frequent application of high concentration topical fluoride may be of some benefit in preventing further demineralisation and increase the abrasion resistance of erosion lesions...
  89. ncbi The potential of saliva in protecting against dental erosion
    Anderson T Hara
    Department of Preventive and Community Dentistry, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, Ind, USA
    Monogr Oral Sci 25:197-205. 2014
    ..Saliva plays a role in the formation of the acquired dental pellicle, a perm-selective membrane that prevents the contact of the acid with the tooth surfaces...
  90. pmc Salivary pellicles on titanium and their effect on metabolic activity in Streptococcus oralis
    Marjan Dorkhan
    Department of Oral Biology, Faculty of Odontology, Malmo University, Malmö SE 20506, Sweden
    BMC Oral Health 13:32. 2013
    ..We have characterized salivary pellicles from titanium surfaces and investigated how contact with uncoated and saliva-coated titanium surfaces affects metabolic activity in adherent cells of S. oralis...
  91. ncbi Differential expression and adherence of Porphyromonas gingivalis FimA genotypes
    C Zheng
    Department of Oral Biology, School of Dentistry, Meharry Medical College, Nashville, TN 37208, USA
    Mol Oral Microbiol 26:388-95. 2011
    ..We show that P. gingivalis strains with genotype I and II of FimA are efficient in interaction with saliva or S. gordonii. This work highlights the important role of FimA type I and II in P. gingivalis attachment to oral surfaces...
  92. ncbi Influence of surface roughness on streptococcal adhesion forces to composite resins
    Li Mei
    Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Dent Mater 27:770-8. 2011
    ..To determine streptococcal adhesion forces with composite resins with different surface roughness...
  93. ncbi Bioactivity and cellular structure of Candida albicans and Candida glabrata biofilms grown in the presence of fluconazole
    Priscila Nogueira Gomes
    Department of Prosthodontics and Periodontology, Piracicaba Dental School, State University of Campinas, Avenida Limeira no 901, Piracicaba, Sao Paulo, CEP 13 414 903, Brazil
    Arch Oral Biol 56:1274-81. 2011
    ..The aim of this study was to evaluate whether fluconazole (FLZ) could affect the bioactivity and cellular structure of Candida albicans or Candida glabrata biofilms grown in the presence of FLZ...
  94. ncbi Influence of two different fluoride compounds and an in vitro pellicle on the amount of KOH-soluble fluoride and its retention after toothbrushing
    Florian J Wegehaupt
    Clinic for Preventive Dentistry, Periodontology and Cariology University of Zurich, Zurich, Switzerland
    Acta Odontol Scand 67:355-9. 2009
    ..To determine the influence of two different fluoride compounds and an in vitro pellicle on KOH-soluble fluoride formation - its retention and resistance to toothbrushing...
  95. ncbi Laboratory studies on the chemical whitening effects of a sodium hexametaphosphate dentifrice
    Arif A Baig
    Procter and Gamble Company, Health Care Research Center, Mason, OH, USA
    J Clin Dent 13:19-24. 2002
    ....
  96. ncbi Design of erosion/abrasion studies--insights and rational concepts
    Annette Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, Centre for Dental and Oral Medicine and Craniomaxillofacial Surgery, University of Zurich, Zurich, Switzerland
    Caries Res 45:53-9. 2011
    ..Experimental parameters must be chosen with care to ensure that the problem is investigated in an appropriate mode at standardised conditions and with adequate measuring systems to allow prediction of clinical outcomes...
  97. ncbi Effect of water storage of E-glass fiber-reinforced composite on adhesion of Streptococcus mutans
    J Tanner
    Institute of Dentistry, and Biomaterials Research, University of Turku, Finland
    Biomaterials 22:1613-8. 2001
    ..The results of this in vitro study suggest that in order to avoid the possible increase in S. mutans adhesion, the reinforcing glass fibers should be covered with the matrix polymer of the composite...
  98. ncbi Inhibition of hydroxyapatite dissolution by whole casein: the effects of pH, protein concentration, calcium, and ionic strength
    Michele E Barbour
    Department of Oral and Dental Science, University of Bristol, Bristol, UK
    Eur J Oral Sci 116:473-8. 2008
    ..The reduction in dissolution rate is ascribed to firmly adsorbed casein on the hydroxyapatite surface, which stabilizes the crystal surface and inhibits ion detachment...
  99. ncbi Molecular cloning of human submandibular histatins
    J C vanderSpek
    Department of Biochemistry, Boston University School of Medicine, MA 02118
    Arch Oral Biol 35:137-43. 1990
    ..A Northern blot of macaque parotid gland total RNA also showed three histatin mRNAs, indicating that similar histatins exist in a non-human primate...
  100. ncbi Preventing erosion with novel agents
    X Wang
    Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Freiburgstrasse 7, CH 3010 Bern, Switzerland
    J Dent 39:163-70. 2011
    ..This in vitro study aimed to investigate the protective effect of four commercial novel agents against erosion...
  101. ncbi In vitro quantitative microhardness assessment of enamel with early salivary pellicles after exposure to an eroding cola drink
    G Maupome
    Faculty of Dentistry, University of British Columbia, Vancouver, B C
    Caries Res 33:140-7. 1999
    ..The joint effect of static baths and higher immersion frequency was the most important factor in decreasing hardness...

Research Grants4

  1. IgA1-Regulation of Complement in Periodontal Disease
    ROBERT BOACKLE; Fiscal Year: 2002
    ....
  2. Complement-fixing Bi-Specific Antibodies Against HIV-1
    ROBERT BOACKLE; Fiscal Year: 2007
    ..Our third objective is to evaluate the complement-mediated neutralization of infectious HIV-1 particles by paired combinations of the truncated bi-specific antibodies. [unreadable] [unreadable] [unreadable]..
  3. SALIVA/GLUCOSYLTRANSFERASE INTERACTIONS ON SURFACES
    William Bowen; Fiscal Year: 2002
    ..Such information may make it possible to design molecules which will compete with S. mutans and certain actinomyces for sites on glucan-coated pellicle. ..
  4. Glucosyltransferase as a Marker for Caries Activity
    William Bowen; Fiscal Year: 2005
    ..Our eventual goal (in a future application) is to determine caries risk well before the onset of lesions and to identify those who are caries active short of cavitation or even white spot formation. ..