dental pellicle

Summary

Summary: A thin protein film on the surface of DENTAL ENAMEL. It is widely believed to result from the selective adsorption of precursor proteins present in SALIVA onto tooth surfaces, and to reduce microbial adherence to the TEETH.

Top Publications

  1. ncbi Roles of salivary proteins in the adherence of oral streptococci to various orthodontic brackets
    S-J Ahn
    Department of Orthodontics, College of Dentistry, Seoul National University, 28-22 Yunkeun-Dong, Chongro-Ku, Seoul 110-744, Korea, ROK
    J Dent Res 81:411-5. 2002
  2. ncbi Statherin and histatin 1 reduce parotid saliva-promoted Streptococcus mutans strain MT8148 adhesion to hydroxyapatite surfaces
    A Shimotoyodome
    Biological Science Laboratories, Tokyo, Japan
    Caries Res 40:403-11. 2006
  3. ncbi Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatite
    H Koo
    Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, Brazil
    Caries Res 34:418-26. 2000
  4. ncbi Identification of early microbial colonizers in human dental biofilm
    J Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Appl Microbiol 97:1311-8. 2004
  5. ncbi Action of agents on glucosyltransferases from Streptococcus mutans in solution and adsorbed to experimental pellicle
    D Wunder
    University of Rochester, Center for Oral Biology, NY 14642, USA
    Arch Oral Biol 44:203-14. 1999
  6. ncbi Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS
    Walter L Siqueira
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Proteome Res 6:2152-60. 2007
  7. ncbi Electron microscopic detection and activity of glucosyltransferase B, C, and D in the in situ formed pellicle
    C Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Arch Oral Biol 53:1003-10. 2008
  8. ncbi Effects of Cistus-tea on bacterial colonization and enzyme activities of the in situ pellicle
    Christian Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    J Dent 36:540-5. 2008
  9. ncbi Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface
    Kiran S Ambatipudi
    Departments of Pharmacology and Physiology, Rochester Proteomics Center, University of Rochester Medical Center, Rochester, New York 14642, United States
    J Proteome Res 9:6605-14. 2010
  10. ncbi Sequence of oral bacterial co-adhesion and non-contact brushing
    H C van der Mei
    Department of Biomedical Engineering, University Medical Center Groningen, and University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent Res 86:421-5. 2007

Research Grants

  1. IgA1-Regulation of Complement in Periodontal Disease
    ROBERT BOACKLE; Fiscal Year: 2002
  2. Complement-fixing Bi-Specific Antibodies Against HIV-1
    ROBERT BOACKLE; Fiscal Year: 2007
  3. Health Risks of Problem-Oriented Dental Attenders
    YANFANG REN; Fiscal Year: 2007
  4. Glucosyltransferase as a Marker for Caries Activity
    William Bowen; Fiscal Year: 2005
  5. SALIVA/GLUCOSYLTRANSFERASE INTERACTIONS ON SURFACES
    William Bowen; Fiscal Year: 2002

Detail Information

Publications121 found, 100 shown here

  1. ncbi Roles of salivary proteins in the adherence of oral streptococci to various orthodontic brackets
    S-J Ahn
    Department of Orthodontics, College of Dentistry, Seoul National University, 28-22 Yunkeun-Dong, Chongro-Ku, Seoul 110-744, Korea, ROK
    J Dent Res 81:411-5. 2002
    ..However, salivary pellicles decreased the binding of S. mutans. Collectively, salivary pellicles were found to play a significant role in the initial adhesion of oral streptococci to orthodontic brackets...
  2. ncbi Statherin and histatin 1 reduce parotid saliva-promoted Streptococcus mutans strain MT8148 adhesion to hydroxyapatite surfaces
    A Shimotoyodome
    Biological Science Laboratories, Tokyo, Japan
    Caries Res 40:403-11. 2006
    ..mutans adhesion promoted by parotid saliva. We conclude that ST and HT1 competitively inhibit the adsorption of salivary HMWGP, and thereby reduce S. mutans adhesion onto HA surfaces...
  3. ncbi Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatite
    H Koo
    Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, Brazil
    Caries Res 34:418-26. 2000
    ..There is a need to identify the active compounds of propolis...
  4. ncbi Identification of early microbial colonizers in human dental biofilm
    J Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Appl Microbiol 97:1311-8. 2004
    ..SIGNIFICANCE AND IMPACT OF THE STUDY: The early colonizers of dental plaque are of great importance in the succession stages of biofilm formation and its overall effect on the oral health of the host...
  5. ncbi Action of agents on glucosyltransferases from Streptococcus mutans in solution and adsorbed to experimental pellicle
    D Wunder
    University of Rochester, Center for Oral Biology, NY 14642, USA
    Arch Oral Biol 44:203-14. 1999
    ..These data indicate that the nature of the inhibitor is important, and also whether the Gtf enzyme is in solution or adsorbed to saliva-coated hydroxylapatite...
  6. ncbi Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS
    Walter L Siqueira
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Proteome Res 6:2152-60. 2007
    ..A high intersubject consistency in pellicle composition was observed...
  7. ncbi Electron microscopic detection and activity of glucosyltransferase B, C, and D in the in situ formed pellicle
    C Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Arch Oral Biol 53:1003-10. 2008
    ..Glucosyltransferases (GTFs) represent a virulence factor of mutans streptococci. The aim of the present in situ study was to investigate the distribution of different GTF-isoforms in the pellicle...
  8. ncbi Effects of Cistus-tea on bacterial colonization and enzyme activities of the in situ pellicle
    Christian Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    J Dent 36:540-5. 2008
    ..Polyphenols are expected to have antibacterial properties. Cistus is a tea rich in polyphenols. The aim of the present in situ study was to investigate the effect of Cistus-tea on the pellicle and on the initial oral biofilm...
  9. ncbi Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface
    Kiran S Ambatipudi
    Departments of Pharmacology and Physiology, Rochester Proteomics Center, University of Rochester Medical Center, Rochester, New York 14642, United States
    J Proteome Res 9:6605-14. 2010
    ..Thus, our data demonstrate that the host salivary protein CSP-1 binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface...
  10. ncbi Sequence of oral bacterial co-adhesion and non-contact brushing
    H C van der Mei
    Department of Biomedical Engineering, University Medical Center Groningen, and University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent Res 86:421-5. 2007
    ..At contact, rotary and sonic brushing performed equally well in bacterial removal, while at 4 mm, both had lost some efficacy...
  11. ncbi In situ studies of pellicle formation on hydroxyapatite discs
    A M Vacca Smith
    Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Arch Oral Biol 45:277-91. 2000
    ..It is apparent that this in situ model could be used in screening potential antiplaque agents...
  12. ncbi Salivary receptors for the proline-rich protein-binding and lectin-like adhesins of oral actinomyces and streptococci
    S Ruhl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Building 30, Room 532, National Institutes of Health, Bethesda, MD 20892, USA
    J Dent Res 83:505-10. 2004
    ..These findings suggest the involvement of specific adhesins in bacterial recognition of many adsorbed salivary proteins and glycoproteins...
  13. ncbi Non-contact removal of coadhering and non-coadhering bacterial pairs from pellicle surfaces by sonic brushing and de novo adhesion
    H J Busscher
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 111:459-64. 2003
    ..However, non-contact, sonic brushing with only a thin wet film on the substratum may leave footprints to which streptococci preferentially adhere...
  14. ncbi Pathogenesis and modifying factors of dental erosion
    J H Meurman
    Faculty of Dentistry, University of Kuopio, Finland
    Eur J Oral Sci 104:199-206. 1996
    ..Neither is there consensus as to how effective fluorides are in preventing the progression of erosive lesions, or how the chemical and structural factors of tooth tissue in general might modify this pathological process...
  15. ncbi Influence of weight on removal of co-adhering bacteria from salivary pellicles by different modes of brushing
    H C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Caries Res 38:85-90. 2004
    ....
  16. ncbi Enzymes in the acquired enamel pellicle
    Christian Hannig
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Eur J Oral Sci 113:2-13. 2005
    ..This review summarizes the present state of research on enzymes and their functions in the dental pellicle. Theoretically, all enzymes present in the oral cavity could be incorporated into the pellicle, but ..
  17. ncbi Protective effect of the in situ formed short-term salivary pellicle
    Matthias Hannig
    Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospitals, Building 73, D 66421 Homburg Saar, Germany
    Arch Oral Biol 49:903-10. 2004
    ..However, pellicle does not completely inhibit the erosive action of citric acid under the conditions of the present study...
  18. ncbi The anti-adherence effect of Piper betle and Psidium guajava extracts on the adhesion of early settlers in dental plaque to saliva-coated glass surfaces
    Fathilah Abdul Razak
    Department of Oral Biology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
    J Oral Sci 45:201-6. 2003
    ..It is therefore suggested that the plant extracts, in expressing their anti-adherence activities, could have altered the hydrophobic nature of the bonding between the bacteria and the saliva-coated glass surfaces...
  19. ncbi Probiotic bacteria affect the composition of salivary pellicle and streptococcal adhesion in vitro
    A Haukioja
    Postgraduate School of Oral Health Sciences, Institute of Dentistry, Universeity of Turku, Turku, Finland
    Oral Microbiol Immunol 23:336-43. 2008
    ..The aim of this study was to investigate in vitro if the probiotic bacteria used in commercial products affect the protein composition of the salivary pellicle and the adherence of other oral bacteria...
  20. ncbi Adhesion of salivary components to Streptococcus mutans peptides
    Jairo A Tovar
    Dental Research Center, School of Dentistry, Javeriana University, Bogot, Colombia
    Acta Odontol Latinoam 19:53-8. 2006
    ..This suggests that the examined PAc's are not relevant as far as the initial adhesion of Streptococcus mutans to the tooth's surface is concerned, as defined by the similarities in the results for healthy and affected individuals...
  21. ncbi In vitro inhibition of oral streptococci binding to the acquired pellicle by algal lectins
    E H Teixeira
    Faculdade de Medicina de Sobral, Universidade Federal do Ceara, Fortaleza CE, Brazil
    J Appl Microbiol 103:1001-6. 2007
    ..This work aimed to evaluate the potential of two algal lectins to inhibit the adherence of five streptococci species to the acquired pellicle in vitro...
  22. ncbi Peptidomic analysis of human acquired enamel pellicle
    Rui Vitorino
    Department of Chemistry, University of Aveiro, Aveiro, Portugal
    Biomed Chromatogr 21:1107-17. 2007
    ..In the case of acidic proline-rich proteins, a clearly predominance of cleavage of the Gln-Gly amide bond was evident...
  23. ncbi Real-time interaction of oral streptococci with human salivary components
    M Kawashima
    Department of Cariology and Operative Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 18:220-5. 2003
    ..mutans was 2 times higher in than S. mitis (3.8) and slightly higher than S. sanguis (7.2). These findings may provide useful information regarding the mechanism of early biofilm formation by streptococci on the tooth surface...
  24. ncbi Influence of oral detergents and chlorhexidine on soft-layer electrokinetic parameters of the acquired enamel pellicle
    H J Busscher
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Caries Res 37:431-6. 2003
    ....
  25. ncbi [Saliva as a main component of oral cavity ecosystem. Part II. Defense mechanisms]
    Anna K Jankowska
    Zakładu Stomatologii Dzieciqcej, Akademii Medycznej w Białymstoku
    Wiad Lek 60:253-7. 2007
    ..Some proteins of innate defense system have bactericidal or bacteriostatic effects; some can cause aggregation of oral bacteria resulting in their increased clearance from oral cavity...
  26. ncbi [The effects of natural medicine on adherence of Streptococcus mutans to salivary acquired pellicle]
    Yue Xiao
    West China School of Stomatology, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 35:687-9. 2004
    ....
  27. ncbi Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro
    A Haukioja
    Institute of Dentistry, University of Turku, Turku, Finland
    Oral Microbiol Immunol 21:326-32. 2006
    ..Our aim was to evaluate the oral colonization potential of different probiotic, dairy, and fecal Lactobacillus and Bifidobacterium strains in vitro...
  28. ncbi Adsorption of chlorhexidine and black tea onto in vitro salivary pellicles, as studied by ellipsometry
    Andrew Joiner
    Unilever Oral Care, Port Sunlight Laboratory, Wirral, Merseyside, UK
    Eur J Oral Sci 114:337-42. 2006
    ..Thus, following exposure to chlorhexidine, the accelerated adsorption of salivary and black tea components can ultimately lead to increased staining of the pellicle...
  29. ncbi Exposure time of enamel and dentine to saliva for protection against erosion: a study in vitro
    S Wetton
    Division of Restorative Dentistry, University of Bristol, Dental School, Bristol, UK
    Caries Res 40:213-7. 2006
    ..Cautiously extrapolating these in vitro data suggests that pellicle should offer erosion protection to individuals who imbibe acidic drinks at frequencies of 1 h or less...
  30. ncbi Biological factors
    Anderson T Hara
    Department of Preventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis, IN 46202-2876, USA
    Monogr Oral Sci 20:88-99. 2006
    Biological factors such as saliva, acquired dental pellicle, tooth structure and positioning in relation to soft tissues and tongue are related to dental erosion development...
  31. ncbi Understanding the chemistry of dental erosion
    J D B Featherstone
    Department of Preventive and Restorative Dental Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Monogr Oral Sci 20:66-76. 2006
    ..Values of the strength of acid (pKa) and for the anion-calcium interaction and the mechanisms of interaction with the tooth mineral on the surface and underneath are described in detail...
  32. ncbi Influence of biosurfactant on interactive forces between mutans Streptococci and enamel measured by atomic force microscopy
    C G van Hoogmoed
    Department of Biomedical Engineering, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent Res 85:54-8. 2006
    ..These findings indicate that adsorbed S. mitis BMS biosurfactant changes the interactive forces between the mutans streptococci studied and enamel, explaining the effects of biosurfactant on adhesion...
  33. ncbi Multi-component adsorption model for pellicle formation: the influence of salivary proteins and non-salivary phospho proteins on the binding of histatin 5 onto hydroxyapatite
    A Yin
    Department of Periodontology and Oral Biology, Boston University Medical Center, 700 Albany Street, Suite W201, Boston, MA 02118, USA
    Arch Oral Biol 51:102-10. 2006
    ..These data suggest that specific protein-protein interactions may play important roles in pellicle formation in vivo...
  34. ncbi Microbubble-induced detachment of coadhering oral bacteria from salivary pellicles
    Prashant K Sharma
    Department of Biomedical Engineering, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 113:326-32. 2005
    ..naeslundii on the pellicle surface, providing nucleation sites for the de novo adhesion of coadhering streptococci...
  35. ncbi Saliva-promoted adhesion of Streptococcus mutans MT8148 associates with dental plaque and caries experience
    A Shimotoyodome
    Biological Science Laboratories, Tochigi, Japan
    Caries Res 41:212-8. 2007
    ..In conclusion, the present findings suggest the initial S. mutans adhesion, modulated by salivary protein adsorption onto the enamel surface, as a possible correlate of susceptibility to dental plaque and caries...
  36. ncbi Assessment of enamel erosion and protective effect of salivary pellicle by surface roughness analysis and scanning electron microscopy
    Yuriy Nekrashevych
    Department of Periodontology and Conservative Dentistry, Saarland University, Homburg, Germany
    Oral Health Prev Dent 2:5-11. 2004
    ..To assess dental erosion caused by 0.1% and 1.0% citric acid in vitro and to estimate the protective influence of experimentally formed salivary pellicle...
  37. ncbi [The effects of traditional Chinese medicines on the adherence of Streptococcus mutans to salivary acquired pellicle in vitro]
    Zhengwei Huang
    West China School of Stomatology, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 34:135-7. 2003
    ..CONCLUSION: Galla Chinensis may be a prospective medicine to inhibit the cariogenic bacteria's preliminary adherence to salivary acquired pellicles...
  38. ncbi Ellipsometry analysis of the in vitro adsorption of tea polyphenols onto salivary pellicles
    Andrew Joiner
    Unilever Oral Care, Port Sunlight Laboratory, Quarry Road East, Bebington, Wirral, Merseyside CH63 3JW, UK
    Eur J Oral Sci 112:510-5. 2004
    ..Therefore, black tea and its polyphenol components are indicated to have a profound effect on in vitro pellicle modification. Similar effects were observed for tannic acid...
  39. ncbi Electron microscopic detection of salivary alpha-amylase in the pellicle formed in situ
    Daniela Deimling
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetterstr 55, D 79106 Freiburg, Germany
    Eur J Oral Sci 112:503-9. 2004
    ..It could be concluded that alpha-amylase might act as a receptor for bacterial adherence to the pellicle in vivo...
  40. ncbi Bacteria-binding plasma proteins in pellicles formed on hydroxyapatite in vitro and on teeth in vivo
    A Carlen
    Department of Oral Microbiology, Institute of Odontology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Oral Microbiol Immunol 18:203-7. 2003
    Previous studies on dental pellicle formation and bacterial adherence have focussed on saliva and its components. The tooth surface is, however, also exposed to the plasma-derived crevicular fluid. In the present study, (i)...
  41. ncbi Adsorption of parotid saliva proteins and adhesion of Streptococcus mutans ATCC 21752 to dental fiber-reinforced composites
    Johanna Tanner
    Institute of Dentistry and Biomaterials Research, University of Turku, Finland
    J Biomed Mater Res B Appl Biomater 66:391-8. 2003
    ..Higher quantities of S. mutans binding proteins in the pellicles may in part account for the higher S. mutans adhesion to saliva-coated ceramic and polyethylene FRC...
  42. ncbi Immediate erosive potential of cola drinks and orange juices
    T Jensdottir
    Department of Oral Medicine, School of Dentistry, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
    J Dent Res 85:226-30. 2006
    ..However, salivary proteins reduced the erosive potential of cola drinks by up to 50%...
  43. ncbi Compositional analysis of human acquired enamel pellicle by mass spectrometry
    Y Yao
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 700 Albany Street, Suite W201, Boston, MA 02118, USA
    Arch Oral Biol 46:293-303. 2001
    ..Unique features of the oral environment such as enzymatic activities or mineral surface properties may account for these differences between in vivo and in vitro pellicle formation...
  44. ncbi Hexametaphosphate effects on tooth surface conditioning film chemistry--in vitro and in vivo studies
    Henk J Busscher
    University of Groningen, Department of Biomedical Engineering, Groningen, The Netherlands
    J Clin Dent 13:38-43. 2002
    ..These surface chemistries may contribute to the unique clinical actions of hexametaphosphate established in recently reported, randomized clinical studies of tartar control, stain prevention and stain removal effects...
  45. ncbi Bacterial detachment from salivary conditioning films by dentifrice supernates
    Henny C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    J Clin Dent 13:44-9. 2002
    ....
  46. ncbi [Non mucin proteins of saliva with high homology of polypeptide chains]
    A Zalewska

    Postepy Hig Med Dosw 55:733-54. 2001
    ..Most of them are able to inhibit the formation of dental calculus and control the calcium phosphate homeostasis...
  47. ncbi Sites of dental erosion are saliva-dependent
    W G Young
    School of Dentistry, The University of Queensland, Brisbane, Queensland, Australia
    J Oral Rehabil 29:35-43. 2002
    ....
  48. ncbi Characterization of the immunologic responses to human in vivo acquired enamel pellicle as a novel means to investigate its composition
    J Li
    Department of Periodontology, Boston University Goldman School of Dental Medicine, Boston, MA, USA
    Oral Microbiol Immunol 18:183-91. 2003
    ..The results open up the possibility that immunization with human pellicle and mAbs production can be employed to identify hitherto unknown constituents of pellicle...
  49. ncbi Maintaining the integrity of the enamel surface: the role of dental biofilm, saliva and preventive agents in enamel demineralization and remineralization
    Franklin Garcia-Godoy
    Bioscience Research Center, College of Dental Medicine, Nova Southeastern University, 3200 S University Drive, Fort Lauderdale, FL 33328, USA
    J Am Dent Assoc 139:25S-34S. 2008
    ..Dental caries is an infectious disease, and it affects 90 percent of late adolescents and young adults in the United States. It is a complex disease that occurs along the interface between the dental biofilm and the enamel surface...
  50. ncbi Surfactive and antibacterial activity of cetylpyridinium chloride formulations in vitro and in vivo
    Henk J Busscher
    Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Clin Periodontol 35:547-54. 2008
    ..To compare effects of three cetylpyridinium chloride (CPC) formulations with and without alcohol and Tween80 on physico-chemical properties of salivary pellicles, bacterial detachment in vitro and bacterial killing in vivo...
  51. ncbi Adhesion of Streptococcus mutans to different types of brackets
    William Papaioannou
    Department of Preventive and Community Dentistry, University of Athens Dental School, Athens, Greece
    Angle Orthod 77:1090-5. 2007
    ..To examine the difference in the adhesion of Streptococcus mutans to three different types of orthodontic brackets and the effect of the presence of an early salivary pellicle and Streptococcus sanguis on adhesion...
  52. ncbi Adhesion of oral streptococci to all-ceramics dental restorative materials in vitro
    R Meier
    Institute of Preventive Dentistry and Oral Microbiology, Dental School, University of Basel, Hebelstrasse 3, 4056 Basel, Switzerland
    J Mater Sci Mater Med 19:3249-53. 2008
    ..This presented in vitro technique may provide a useful model to study the influence of different parameters on adherence of oral streptococcal species...
  53. ncbi Protective effect of different tetrafluorides on erosion of pellicle-free and pellicle-covered enamel and dentine
    A Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Zurich, Switzerland
    Caries Res 42:247-54. 2008
    ..Tetrafluoride solutions, especially 1% TiF(4), could decrease dental erosion, but were more effective on dentine than on enamel...
  54. ncbi Impact of the in situ formed salivary pellicle on enamel and dentine erosion induced by different acids
    Annette Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Zurich, Switzerland
    Acta Odontol Scand 66:225-30. 2008
    ..To investigate and compare the protective impact of the in situ formed salivary pellicle on enamel and dentine erosion caused by different acids at pH 2.6...
  55. ncbi Design of erosion/abrasion studies--insights and rational concepts
    Annette Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, Centre for Dental and Oral Medicine and Craniomaxillofacial Surgery, University of Zurich, Zurich, Switzerland
    Caries Res 45:53-9. 2011
    ..Experimental parameters must be chosen with care to ensure that the problem is investigated in an appropriate mode at standardised conditions and with adequate measuring systems to allow prediction of clinical outcomes...
  56. ncbi Effect of TiF4, ZrF4, HfF4 and AmF on erosion and erosion/abrasion of enamel and dentin in situ
    Annette Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
    Arch Oral Biol 55:223-8. 2010
    ..This in situ study aimed to analyse the impact of different tetrafluorides (TiF(4), ZrF(4) and HfF(4)) and AmF on erosion and erosion plus abrasion of enamel and dentin...
  57. ncbi Salivary mucin MUC5B could be an important component of in vitro pellicles of human saliva: an in situ ellipsometry and atomic force microscopy study
    Marité Cárdenas
    Biomedical Laboratory Science, Faculty of Health and Society, Malmo University, SE 205 06 Malmo, Sweden
    Biomacromolecules 8:1149-56. 2007
    ..Therefore, these large mucins can be responsible for the increased resistance of HWS films on hydrophobic substrates and can protect the intraoral surfaces against surface-active components present in oral health care products...
  58. ncbi Inhibition of Streptococcus mutans adherence and biofilm formation using analogues of the SspB peptide
    Kentaro Okuda
    Department of Oral Health, Technology and Epidemiology, Graduate School of Dental Science, Kyusyu University, Fukuoka, 113 8549, Japan
    Arch Oral Biol 55:754-62. 2010
    ..To characterize the analogue peptide biological activities, we investigated its binding and inhibiting effects, and the role of its amino acid moities...
  59. ncbi Oral streptococci growth on aging and non-aging esthetic restorations after radiotherapy
    Adriana D da Cruz
    Department of Oral Diagnosis, Area of Dental Radiology, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil
    Braz Dent J 21:346-50. 2010
    ..05). The exposure to ionizing radiation at therapeutic doses promoted changes in bacterial adherence of aged dental restorative material...
  60. ncbi Erosive tooth wear: diagnosis, risk factors and prevention
    Adrian Lussi
    Department of Preventive, Restorative and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, CH 3010, Switzerland
    Am J Dent 19:319-25. 2006
    ..The frequent use of fluoride gel and fluoride mouthrinse in addition to fluoride toothpaste offers the opportunity to minimize abrasion of tooth substance...
  61. ncbi Efficacy and mechanisms of non-antibacterial, chemical plaque control by dentifrices--an in vitro study
    Henk J Busscher
    Department of Biomedical Engineering, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent 35:294-301. 2007
    ..It is the aim of this paper to analyze in vitro detachment of co-aggregating oral actinomyces and streptococci from pellicle surfaces by dentifrice supernates and to study subsequent de novo streptococcal deposition...
  62. ncbi An in vitro model of chlorhexidine-induced tooth staining
    G H Carpenter
    Salivary Research Unit, GKT Dental School, Guys Hospital, London, UK
    J Periodontal Res 40:225-30. 2005
    ..Although the mechanism of tooth staining is uncertain, diet, smoking and oral hygiene appear probable factors...
  63. ncbi Histatin 1 resists proteolytic degradation when adsorbed to hydroxyapatite
    E E McDonald
    School of Dentistry, Dental Sciences Building DSB0071, Schulich School of Medicine and Dentistry, The University of Western Ontario, London N6A 5C1, ON, Canada
    J Dent Res 90:268-72. 2011
    ..This study shows for the first time that binding to hydroxyapatite confers intact histatin 1 with resistance to proteolytic degradation...
  64. ncbi Inhibition of hydroxyapatite dissolution by whole casein: the effects of pH, protein concentration, calcium, and ionic strength
    Michele E Barbour
    Department of Oral and Dental Science, University of Bristol, Bristol, UK
    Eur J Oral Sci 116:473-8. 2008
    ..The reduction in dissolution rate is ascribed to firmly adsorbed casein on the hydroxyapatite surface, which stabilizes the crystal surface and inhibits ion detachment...
  65. ncbi Bacterial adhesion on smooth and rough titanium surfaces after treatment with different instruments
    Poliana Mendes Duarte
    Department of Periodontics, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil
    J Periodontol 80:1824-32. 2009
    ....
  66. ncbi Influence of a chitosan on oral bacterial adhesion and growth in vitro
    Henk J Busscher
    Department of Biomedical Engineering, University Medical Center Groningen and University of Groningen, Antonius Deusinglaan, Groningen, The Netherlands
    Eur J Oral Sci 116:493-5. 2008
    ..oralis HM1. Therefore, chitosan is a promising antimicrobial for use in oral healthcare...
  67. ncbi Bond strength of a pit-and-fissure sealant associated to etch-and-rinse and self-etching adhesive systems to saliva-contaminated enamel: individual vs. simultaneous light curing
    Jaciara Miranda Gomes-Silva
    Department of Pediatric Clinic, Preventive and Community Dentistry, Dental School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 19:341-7. 2008
    ....
  68. ncbi The effect of acidic beverages on the ultrastructure of the acquired pellicle--an in situ study
    C Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Arch Oral Biol 54:518-26. 2009
    ..The aim of the present in situ study was to investigate ultrastructural alterations as well as protective properties of the pellicle layer during consumption of acidic beverages...
  69. ncbi Adhesion of Streptococcus mutans to salivary proteins in caries-free and caries-susceptible individuals
    Pacífico Castro
    Dental Research Center, School of Dentistry, Javeriana University, Bogota, Colombia
    Acta Odontol Latinoam 19:59-66. 2006
    ..However, these are interesting findings that may contribute to the design of strategies to control the adhesion of S. mutans to the tooth's surface...
  70. ncbi Individual variations in protective effects of experimentally formed salivary pellicles
    M Bruvo
    Department of Oral Microbiology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Caries Res 43:163-70. 2009
    ..We conclude that individual variations in experimental pellicle protection against erosive challenges exist and that such variations appear not to be due to differences in a single protein component...
  71. ncbi Effect of sodium, amine and stannous fluoride at the same concentration and different pH on in vitro erosion
    Annette Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, CH 8032 Zurich, Switzerland
    J Dent 37:591-5. 2009
    ..This study aimed to compare the effects 0.5% and 1% sodium, amine and stannous fluoride at different pH on enamel erosion in vitro...
  72. ncbi In vitro evaluation of yoghurt starter lactobacilli and Lactobacillus rhamnosus GG adhesion to saliva-coated surfaces
    I Stamatova
    Faculty of Dental Medicine, Medical University, Plovdiv, Bulgaria
    Oral Microbiol Immunol 24:218-23. 2009
    ..The aim of the study was to evaluate the adhesion of Lactobacillus delbrueckii subsp. bulgaricus and Lactobacillus rhamnosus strain GG to saliva-coated surfaces in vitro...
  73. ncbi Morphological and chemical characterization of tooth enamel exposed to alkaline agents
    F Taube
    Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, SE 405 30 Gothenburg, Sweden
    J Dent 38:72-81. 2010
    ..In addition, chemical effects of the organic surface layer, i.e. plaque and pellicle, were also investigated...
  74. ncbi Effects of Nidus Vespae extract and chemical fractions on glucosyltransferases, adherence and biofilm formation of Streptococcus mutans
    Jin Xiao
    Key Laboratory for Oral Biomedical Engineering Ministry of Education, Chengdu, China
    Arch Oral Biol 52:869-75. 2007
    ..The significant inhibition of GTFs activity and biofilm formation demonstrated by Nidus Vespae shows it to be a promising natural product for the prevention of dental caries...
  75. ncbi Preventing erosion with novel agents
    X Wang
    Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Freiburgstrasse 7, CH 3010 Bern, Switzerland
    J Dent 39:163-70. 2011
    ..This in vitro study aimed to investigate the protective effect of four commercial novel agents against erosion...
  76. ncbi The effect of Piper betle and Psidium guajava extracts on the cell-surface hydrophobicity of selected early settlers of dental plaque
    Fathilah Abdul Razak
    Department of Oral Biology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
    J Oral Sci 48:71-5. 2006
    ..It was also observed that the anti-adhesive effect of the two extracts on the binding of the early plaque settlers to hexadecane is concentration dependent...
  77. ncbi Proteolytic degradation of oral biofilms in vitro and in vivo: potential of proteases originating from Euphausia superba for plaque control
    C H Berg
    YKI, Institute for Surface Chemistry, Stockholm, Sweden
    Eur J Oral Sci 109:316-24. 2001
    ..Our results demonstrate the potential of Krillase for plaque control, and that these enzymes are worthy of further investigations including clinical studies and work to find a suitable vehicle...
  78. ncbi Adherence of Candida species to newly polymerized and water-stored denture base polymers
    T Waltimo
    NIOM, Scandinavian Institute of Dental Materials, Haslum, Norway
    Int J Prosthodont 14:457-60. 2001
    ..The aim of this in vitro study was to examine the adherence of yeasts to newly polymerized and water-stored denture base polymers using four Candida strains with different cell surface hydrophobicities...
  79. ncbi Moderation of oral bacterial adhesion on saliva-coated hydroxyapatite by polyaspartate
    Y H Guan
    University of Sheffield and Boots National Centre for Applied Research into Oral Health, and Department of Oral Health and Development, School of Clinical Dentistry, Sheffield S10 2TA, UK
    J Appl Microbiol 94:456-61. 2003
    ..Synthetic sodium alpha,beta-polyaspartate (PA) has been investigated as a moderator of adhesion and the subsequent biofilm formation by oral bacteria...
  80. ncbi Experimental salivary pellicles formed on the surface of self-curing resin
    J-H Yoo
    Department of Oral Medicine and Oral Diagnosis, College of Dentistry, Seoul National University, Seoul, South Korea
    J Oral Rehabil 30:251-9. 2003
    ..The findings of this study provide information concerning the initial bacterial adhesion on the surfaces of self-curing resin...
  81. ncbi Letter to the editor: "The effect of acquired salivary pellicle on the surface free energy and wettability of different denture base materials" [C. Sipahi, N. Anil, E Bayramli Journal of Dentistry 29 (2001) 197-204]
    Edward C Combe
    J Dent 30:383; author reply 384-5. 2002
  82. ncbi Influence of dentifrices and dietary components in saliva on wettability of pellicle-coated enamel in vitro and in vivo
    H C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 110:434-8. 2002
    ....
  83. ncbi Electron-microscopic demonstration of proline-rich proteins, statherin, and histatins in acquired enamel pellicles in vitro
    P Schupbach
    Institute of Oral Microbiology and General Immunology, University of Zurich, Switzerland
    Eur J Oral Sci 109:60-8. 2001
    ....
  84. ncbi Supragingival calculus: formation and control
    Ye Jin
    Graduate Student, Faculty of Dentistry, The University of Hong Kong, Hong Kong, P.R. China
    Crit Rev Oral Biol Med 13:426-41. 2002
    ....
  85. ncbi Dental biofilms at healthy and inflamed gingival margins
    S G Rüdiger
    Department of Oral Microbiology, Institute of Odontology, Goteborg University, Goteborg, Sweden
    J Clin Periodontol 29:524-30. 2002
    ..Receptor proteins in the dental pellicle might influence bacterial adhesion and subsequent plaque formation...
  86. ncbi Preliminary evaluation of salivary pellicle on nickel-chromium alloy in vivo
    A Nehir Ozden
    Ankara University, Ankara, Turkey
    Quintessence Int 33:731-5. 2002
    ..Because both salivary amylase and secretory immunoglobulin A are antimicrobial proteins, it is possible that they play a role in modulating the microbial flora on the nickel-chromium prosthesis...
  87. ncbi Effect of water storage of E-glass fiber-reinforced composite on adhesion of Streptococcus mutans
    J Tanner
    Institute of Dentistry, and Biomaterials Research, University of Turku, Finland
    Biomaterials 22:1613-8. 2001
    ..The results of this in vitro study suggest that in order to avoid the possible increase in S. mutans adhesion, the reinforcing glass fibers should be covered with the matrix polymer of the composite...
  88. ncbi Pits and fissures: etch resistance in prismless enamel walls
    M F Burrow
    School of Dental Science, The University of Melbourne
    Aust Dent J 46:258-62. 2001
    ....
  89. ncbi Current concept on the anticaries fluoride mechanism of the action
    K Rosin-Grget
    Department of Pharmacology, School of Dental Medicine, University of Zagreb, Croatia
    Coll Antropol 25:703-12. 2001
    ..The CaF2, therefore, act as an efficient source of free fluoride ions during the cariogenic challenge. These are subsequently incorporated into the enamel as hydroxyfluorapatite or fluorapatite...
  90. ncbi Recent concepts in plaque formation
    J-P Bernimoulin
    Department of Periodontology and Synoptic Dentistry, Humboldt University, Berlin, Germany
    J Clin Periodontol 30:7-9. 2003
    ..Ideally, an effective agent would also penetrate the plaque biofilm. Data show that essential oil and chlorhexidine mouthwashes have the broadest antimicrobial effects...
  91. ncbi Adhesion of oral streptococci to experimental bracket pellicles from glandular saliva
    Sug-Joon Ahn
    College of Dentistry, Seoul National University, Seoul, South Korea
    Am J Orthod Dentofacial Orthop 124:198-205. 2003
    ..These findings suggest that numerous salivary proteins can adhere selectively to the orthodontic brackets, and some of them contribute to the binding of S gordonii...
  92. ncbi In vitro inhibition of Streptococci binding to enamel acquired pellicle by plant lectins
    E H Teixeira
    Medical School of Sobral, Federal University of Cear, Brazil
    J Appl Microbiol 101:111-6. 2006
    ..CONCLUSIONS: All lectins were able to inhibit the adherence of the microorganisms tested (p < 0.01). SIGNIFICANCE AND IMPACT OF THE STUDY: Our results suggest that lectins may be useful in anti adhesion therapeutics...
  93. ncbi Interaction between attrition,abrasion and erosion in tooth wear
    M Addy
    Applied Clinical Research Group, Bristol University Dental School, Bristol, UK
    Monogr Oral Sci 20:17-31. 2006
    ..Saliva can modulate erosive/abrasive tooth wear through formation of pellicle and by remineralisation but cannot prevent it...
  94. ncbi Molecular cloning of human submandibular histatins
    J C vanderSpek
    Department of Biochemistry, Boston University School of Medicine, MA 02118
    Arch Oral Biol 35:137-43. 1990
    ..A Northern blot of macaque parotid gland total RNA also showed three histatin mRNAs, indicating that similar histatins exist in a non-human primate...
  95. ncbi Effects of sanguinaria in fluoride-containing dentifrices on the remineralisation of subsurface carious lesion in vitro
    Suk Jin Hong
    Department of Preventive Dentistry, College of Dentistry, Kyungpook National University, Daegu, Korea
    Int Dent J 55:128-32. 2005
    ..The purpose of this study was to investigate the potential cariostatic benefits of dentifrice containing both fluoride (F) and sanguinaria (SG) in a silica abrasive formula using the microbial de- and re-mineralisation cycle model...
  96. ncbi Laboratory studies on the chemical whitening effects of a sodium hexametaphosphate dentifrice
    Arif A Baig
    Procter and Gamble Company, Health Care Research Center, Mason, OH, USA
    J Clin Dent 13:19-24. 2002
    ....
  97. ncbi New laboratory methods to study tooth surface coverage and interproximal plaque control by dentifrice products
    Tao Xu
    Colgate Palmolive Technology Center, Piscataway, NJ, USA
    J Clin Dent 15:123-7. 2004
    ..The application of the model should offer visual evaluation of dentifrice coverage of the tooth surface, and measure dental plaque control at posterior interdental spaces with a dentifrice...
  98. ncbi An in situ investigation into the abrasion of eroded dental hard tissues by a whitening dentifrice
    C P Turssi
    Department of Restorative Dentistry, School of Dentistry of Piracicaba, State University of Campinas, Brazil
    Caries Res 38:473-7. 2004
    ..The results suggest that whitening dentifrices may not increase the wear of acid-softened enamel but may have a more deleterious effect on dentine than regular toothpastes...
  99. ncbi The effects of a new therapeutic triclosan/copolymer/sodium-fluoride dentifrice on oral bacteria, including odorigenic species
    David Furgang
    Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    Compend Contin Educ Dent 24:14-9; quiz 42. 2003
    ....
  100. ncbi Salivary proteins: protective and diagnostic value in cariology?
    A van Nieuw Amerongen
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands a van_nieuw_
    Caries Res 38:247-53. 2004
    ..These are potentially suited as templates for the design of a new generation of antibiotics, since they kill a broad spectrum of microorganisms, while hardly evoking resistance, in contrast to the classical antibiotics...
  101. ncbi In vitro quantitative microhardness assessment of enamel with early salivary pellicles after exposure to an eroding cola drink
    G Maupome
    Faculty of Dentistry, University of British Columbia, Vancouver, B C
    Caries Res 33:140-7. 1999
    ..The joint effect of static baths and higher immersion frequency was the most important factor in decreasing hardness...

Research Grants11

  1. IgA1-Regulation of Complement in Periodontal Disease
    ROBERT BOACKLE; Fiscal Year: 2002
    ....
  2. Complement-fixing Bi-Specific Antibodies Against HIV-1
    ROBERT BOACKLE; Fiscal Year: 2007
    ..Our third objective is to evaluate the complement-mediated neutralization of infectious HIV-1 particles by paired combinations of the truncated bi-specific antibodies. ..
  3. Health Risks of Problem-Oriented Dental Attenders
    YANFANG REN; Fiscal Year: 2007
    ..This is particularly important as nearly 40% of the general population meet the definition of POAs and many of them may not have a regular source of medical care. ..
  4. Glucosyltransferase as a Marker for Caries Activity
    William Bowen; Fiscal Year: 2005
    ..Our eventual goal (in a future application) is to determine caries risk well before the onset of lesions and to identify those who are caries active short of cavitation or even white spot formation. ..
  5. SALIVA/GLUCOSYLTRANSFERASE INTERACTIONS ON SURFACES
    William Bowen; Fiscal Year: 2002
    ..Such information may make it possible to design molecules which will compete with S. mutans and certain actinomyces for sites on glucan-coated pellicle. ..