dental cementum

Summary

Summary: The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)

Top Publications

  1. ncbi Treatment of furcation defects with an allograft-alloplast-tetracycline composite bone graft combined with GTR: human histologic evaluation of a case report
    Randall J Harris
    Int J Periodontics Restorative Dent 22:381-7. 2002
  2. ncbi Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting
    David L Cochran
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1269-81. 2003
  3. ncbi Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone
    Myron Nevins
    Institute for Advanced Dental Studies, Swampscott, MA, USA
    J Periodontol 74:1282-92. 2003
  4. ncbi Possible role of dentin matrix in region-specific deposition of cellular and acellular extrinsic fibre cementum
    Yoshiro Takano
    Division of Biostructural Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Electron Microsc (Tokyo) 52:573-80. 2003
  5. ncbi Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain. A histologic study
    N Donos
    Department of Periodontology, Royal Dental College, University of Aarhus, Denmark
    J Clin Periodontol 30:1061-8. 2003
  6. ncbi Detection of dentin sialoprotein in rat periodontium
    Otto Baba
    Department of Endodontics and Periodontics, The University of Texas Houston Health Science Center Dental Branch, Houston, Texas, USA
    Eur J Oral Sci 112:163-70. 2004
  7. ncbi [Preservation of alveolar bone of un-restorable traumatized maxillary incisors for future]
    I Levin
    Dept. of Restorative Dentistry, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Refuat Hapeh Vehashinayim 21:54-9, 101-2. 2004
  8. ncbi Periodontal repair in surgically created intrabony defects in dogs: influence of the number of bone walls on healing response
    Chang-Sung Kim
    Department of Periodontology, Research Institute for Periodontal Regeneration, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 75:229-35. 2004
  9. ncbi Enhanced cementum formation in experimentally induced cementum defects of the root surface with the application of recombinant basic fibroblast growth factor in collagen gel in vivo
    Yasuko Sato
    Department of Oral Functional Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    J Periodontol 75:243-8. 2004
  10. ncbi The effect of enamel matrix proteins on periodontal regeneration as determined by histological analyses
    D L Cochran
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1043-55. 2003

Research Grants

  1. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2001
  2. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2007
  3. Key Modulators of Cementogenesis
    Martha J Somerman; Fiscal Year: 2010
  4. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMENTOGENESIS
    Martha Somerman; Fiscal Year: 2006
  5. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2006
  6. Primary Genes Promoting Cementoblast Differentiaton
    Sotirios Tetradis; Fiscal Year: 2007
  7. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2003
  8. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2009
  9. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
  10. Tissue Engineering and Regeneration
    Paul Krebsbach; Fiscal Year: 2007

Detail Information

Publications152 found, 100 shown here

  1. ncbi Treatment of furcation defects with an allograft-alloplast-tetracycline composite bone graft combined with GTR: human histologic evaluation of a case report
    Randall J Harris
    Int J Periodontics Restorative Dent 22:381-7. 2002
    ..In this study, regeneration of a furcation defect in a human was documented with histology...
  2. ncbi Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting
    David L Cochran
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1269-81. 2003
    ..The goal of this study was to evaluate periodontal regeneration in intrabony defects of various sizes treated with a combination of enamel matrix proteins and autogenous bone graft...
  3. ncbi Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone
    Myron Nevins
    Institute for Advanced Dental Studies, Swampscott, MA, USA
    J Periodontol 74:1282-92. 2003
    ....
  4. ncbi Possible role of dentin matrix in region-specific deposition of cellular and acellular extrinsic fibre cementum
    Yoshiro Takano
    Division of Biostructural Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Electron Microsc (Tokyo) 52:573-80. 2003
    ..The timing of mineralization of mantle dentin matrix might be the key determinant of the types of the cementum deposited on the growing root surface...
  5. ncbi Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain. A histologic study
    N Donos
    Department of Periodontology, Royal Dental College, University of Aarhus, Denmark
    J Clin Periodontol 30:1061-8. 2003
    ..However, no histological studies are available investigating the effect of EMD in the treatment of degree III furcation involvements...
  6. ncbi Detection of dentin sialoprotein in rat periodontium
    Otto Baba
    Department of Endodontics and Periodontics, The University of Texas Houston Health Science Center Dental Branch, Houston, Texas, USA
    Eur J Oral Sci 112:163-70. 2004
    ..Together, these observations suggest that DSP is involved in formation of the periodontium as well as tooth structures...
  7. ncbi [Preservation of alveolar bone of un-restorable traumatized maxillary incisors for future]
    I Levin
    Dept. of Restorative Dentistry, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Refuat Hapeh Vehashinayim 21:54-9, 101-2. 2004
    ..Treatment is multidisciplinary, requiring endodontic, surgical, orthodontic, operative and prosthetic compliance. An individual treatment plan for each patient is necessary. General rule do not apply. Periodic check-up is essential...
  8. ncbi Periodontal repair in surgically created intrabony defects in dogs: influence of the number of bone walls on healing response
    Chang-Sung Kim
    Department of Periodontology, Research Institute for Periodontal Regeneration, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 75:229-35. 2004
    ..One- and 3-wall intrabony defects appear to be reproducible models to evaluate candidate technologies for periodontal regeneration...
  9. ncbi Enhanced cementum formation in experimentally induced cementum defects of the root surface with the application of recombinant basic fibroblast growth factor in collagen gel in vivo
    Yasuko Sato
    Department of Oral Functional Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    J Periodontol 75:243-8. 2004
    ....
  10. ncbi The effect of enamel matrix proteins on periodontal regeneration as determined by histological analyses
    D L Cochran
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1043-55. 2003
    ..The goal of this study was to evaluate periodontal regeneration in intrabony defects of various sizes treated with enamel matrix proteins...
  11. ncbi Immunolocalization of calbindin D28k and vitamin D receptor during root formation of murine molar teeth
    Tomoyuki Onishi
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    Anat Rec A Discov Mol Cell Evol Biol 273:700-4. 2003
    ..The present results indicate that CB expression in newly disrupted cells from Hertwig's epithelial root sheath occurs in a vitamin-D dependent manner, whereas the expression of CB in mature ERM cells may be independent of vitamin D...
  12. ncbi Effect of early membrane removal on regeneration of Class II furcation defects in dogs
    Guilherme O Macedo
    Department of Surgery, Oral-Maxillo-Facial Traumatology and Periodontology, , , , Brazil
    J Periodontol 77:46-53. 2006
    ..59 +/- 1.80 (NC). There were no statistically significant differences between TGr and CGr for any measurement. CONCLUSION: The early removal of ePTFE membranes in Class II furcation defects in dogs did not affect periodontal regeneration...
  13. ncbi Effect of porous xenographic bone graft with collagen barrier membrane on periodontal regeneration
    Satoru Yamada
    Department of Periodontics, Tokyo Dental College, Chiba, Japan
    Int J Periodontics Restorative Dent 22:389-97. 2002
    ..The use of the collagen barrier membrane in combination with the porous bone graft material may enhance new bone and cementum formation...
  14. ncbi Cementum formation around a titanium implant: a case report
    Renzo Guarnieri
    Int J Oral Maxillofac Implants 17:729-32. 2002
    ..Further studies are required to establish whether the neoformation of cementum and collagen fibers on an implant in the presence of root residues occurs only in animal models or whether it may also occur in humans...
  15. ncbi Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs
    S Murakami
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Periodontal Res 38:97-103. 2003
    ..The present results indicate that topical application of bFGF can enhance considerable periodontal regeneration in artificially created furcation class II bone defects of beagle dogs...
  16. ncbi Effect of soluble receptors to interleukin-1 and tumor necrosis factor alpha on experimentally induced root resorption in rats
    Dongliang Zhang
    Jilin University, Dental School, Department of Orthodontics, Jilin, People's Republic of China
    J Periodontal Res 38:324-32. 2003
    ..CONCLUSIONS: Our results indicate that IL-1 and more particularly TNFalpha are important for the induction and the further process of mechanically induced root resorption in the rat...
  17. ncbi Biological mediators for periodontal and bone regeneration
    Richard J Oringer
    Department of Periodontics, State University of New York at Stony Brook, School of Dental Medicine, Stony Brook, New York, USA
    Compend Contin Educ Dent 23:501-4, 506-10, 512 passim; quiz 518. 2002
    ..The clinical application of these therapies will be to either replace or augment traditional regenerative treatments...
  18. ncbi Periodontal repair in dogs: evaluation of a bioabsorbable space-providing macroporous membrane with recombinant human bone morphogenetic protein-2
    Ulf M E Wikesjö
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Periodontol 74:635-47. 2003
    ....
  19. ncbi Immunohistochemical evaluation of matrix molecules associated with wound healing following treatment with an enamel matrix protein derivative in humans
    A Sculean
    Department Conservative Dentistry and Periodontology, Johannes Gutenberg University, Augustusplatz 2, 55131 Mainz, Germany
    Clin Oral Investig 7:167-74. 2003
    ....
  20. ncbi Periodontal repair in dogs: gingival tissue occlusion, a critical requirement for GTR?
    Ulf M E Wikesjö
    Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Clin Periodontol 30:655-64. 2003
    ..The importance of cell or tissue occlusion has yet to be established. The objective of this study was to evaluate the role of tissue occlusion as a critical determinant for GTR outcomes...
  21. ncbi Clinical and histologic evaluation of anorganic bovine bone collagen with or without a collagen barrier
    Gary A Hartman
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 78229-3900, USA
    Int J Periodontics Restorative Dent 24:127-35. 2004
    ..Two sites demonstrated new attachment, and four showed a long junctional epithelium. Periodontal regeneration is possible following a bone-replacement graft of Bio-Oss Collagen...
  22. ncbi Locally applied isosorbide decreases bone resorption in experimental periodontitis in rats
    R F C Leitão
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Ceara, Brazil
    J Periodontol 75:1227-32. 2004
    ..We investigated the effect of local administration of the NO donor isosorbide in an experimental periodontal disease model...
  23. ncbi Porcine sheath proteins show periodontal ligament regeneration activity
    Makoto Fukae
    Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    Eur J Oral Sci 114:212-8; discussion 254-6, 381-2. 2006
    ..The 17-kDa sheath protein showed both cytodifferentiation and cementum-regeneration activity, but it is unclear whether its cementum-regeneration activity is derived from its ALP-inducing activity on HPDL cells...
  24. ncbi Pattern of mineralization after regenerative periodontal therapy with enamel matrix proteins
    Dieter D Bosshardt
    Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Berne, Berne, Switzerland
    Eur J Oral Sci 114:225-31; discussion 254-6, 381-2. 2006
    ..The mineralization pattern mostly resembled that found in bone, except for a few areas that exhibited a hitherto undescribed mineralization pattern...
  25. ncbi The 17-kDa sheath protein in enamel proteins induces cementum regeneration in experimental cavities created in a buccal dehiscence model of dogs
    M Kanazashi
    Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    J Periodontal Res 41:193-9. 2006
    ..The purpose of this in vivo study was to identify the cementum regeneration-promoting factor in enamel proteins that is clinically used for periodontal regeneration to induce cementum-promotive and osteopromotive activities...
  26. ncbi The side effects of orthodontic mechanics in orthodontic treatments
    Homan H Javaheri
    Shaheed Beheshti Dental Research Center, Iran
    Int J Orthod Milwaukee 19:11-2. 2008
    ..Root resorption is a well-recognized phenomenon following orthodontic treatment. Advances made in this area of research to identify the parameters and genes associated with this process are developing...
  27. ncbi Experimental intrabony and periodontal defects treated with natural mineral combined with a synthetic cell-binding Peptide in the canine: morphometric evaluations
    Zvi Artzi
    Department of Periodontology, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontol 77:1658-64. 2006
    ..Its efficacy as filler biomaterial in guided tissue regeneration (GTR) and guided bone regeneration (GBR) procedures was evaluated histologically and morphometrically...
  28. ncbi Immunohistochemical study of bone sialoprotein and osteopontin in healthy and diseased root surfaces
    Martin Lao
    Colgate Australian Clinical Dental Research Center, Dental School, University of Adelaide, Adelaide, South Australia, Australia
    J Periodontol 77:1665-73. 2006
    ..This may influence the ability for regeneration and new connective tissue attachment onto previously diseased root surfaces...
  29. ncbi Synchrotron radiation-based microtomography of alveolar support tissues
    M Dalstra
    Department of Orthodontics, School of Dentistry, University of Aarhus, Denmark
    Orthod Craniofac Res 9:199-205. 2006
    ..To study the alveolar support structures using synchrotron radiation (SR)-based microtomography with particular focus on the alveolar surface...
  30. ncbi Interrelation between endodontic status, pathologic cemental granules and periodontal ligament adhering to the root of extracted teeth
    Yango Pohl
    Department of Oral Surgery, University of Bonn, Bonn, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:127-33. 2007
    ....
  31. ncbi Contact damage to root surfaces of premolars touching miniscrews during orthodontic treatment
    Onur Kadioglu
    Department of Orthodontics, College of Dentistry, University of Oklahoma, Oklahoma City, USA
    Am J Orthod Dentofacial Orthop 134:353-60. 2008
    ..Our aim in this clinical study was to examine premolar root surfaces after intentional contact with miniscrews...
  32. ncbi Multiple teeth showing invasive cervical resorption--an entity with little known histologic features
    M Coyle
    Department of Oral Surgery, Oral Pathology and Oral Medicine, School of Dental Science, Trinity College, Dublin, Ireland
    J Oral Pathol Med 35:55-7. 2006
    ..The case highlights the diagnostic difficulty that may arise in this uncommon lesion, the pathologic features of which may be mistaken for a fibro-osseous lesion or a low-grade sarcoma...
  33. ncbi An association of external and internal enamel pearls
    S Mahajan
    Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences
    Indian J Dent Res 16:17-8. 2005
    ..We discussed the histogenesis of enamel pearls and proposed that internal enamel pearl formation may be a continuation of formation of external enamel pearl...
  34. ncbi Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells
    Hiroyuki Kawaguchi
    Department of Periodontal Medicine, Division of Frontier Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Periodontol 75:1281-7. 2004
    ..The purpose of this study was to examine whether auto-transplantation of MSCs into periodontal osseous defects would be useful for periodontal tissue regeneration...
  35. ncbi Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: short-, medium- and long-term healing
    Filippo Graziani
    Department of Periodontology, Eastman Dental Institute, University College London, London, UK
    J Clin Periodontol 32:905-14. 2005
    ..CONCLUSION: Periodontal healing following GTR therapy of recession-type defects will result in a restitutio ad integrum, i.e. healing by re-generation. A continuous maturation process occurs over at least 2 years...
  36. ncbi Cementum and dentin in hypophosphatasia
    T Van den Bos
    Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA, Universiteit van Amsterdam, and Vrije Universiteit, Louwesweg 1, 1066 EA Amsterdam, The Netherlands
    J Dent Res 84:1021-5. 2005
    ..Our findings suggest that mineralization of dentin is less likely to be under the influence of the inhibitory action of pyrophosphate than mineralization of cementum...
  37. ncbi Development of functional dentin incisors after a partial resection of the odontogenic organ of rat incisors
    José Merzel
    Department of Morphology, Faculdade de Odontologia de Piracicaba, UNICAMP, SP, Brazil
    Arch Oral Biol 51:825-35. 2006
    ..These data and our results, showing the development of a functional dentin incisor, suggest that the root-analogue part of the rodent incisor is an anatomic-physiological entity...
  38. ncbi Alveolar bone loss and aging: a model for the study in mice
    Elken G Rivaldo
    Geriatrics and Gerontology Institute, Pontifical Catholic University, Porto Alegre, Rio Grande do Sul, Brazil
    J Periodontol 76:1966-71. 2005
    ..Several animal studies have shown a positive correlation between aging and alveolar bone loss (ABL). The purpose of this study was to develop a model for the study of ABL in mice and aging...
  39. ncbi Progressive, generalized, apical idiopathic root resorption and hypercementosis
    Marc Schätzle
    Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Berne, Berne, Switzerland
    J Periodontol 76:2002-11. 2005
    ..The objective of this report was to present a case of a 17-year-old white female with progressive, generalized, apical idiopathic root resorption followed up for 34 months...
  40. ncbi Effect of an oily calcium hydroxide suspension (Osteoinductal) on healing of intrabony periodontal defects. A pilot study in dogs
    Frank Schwarz
    Department of Oral Surgery, Heinrich Heine University, , Germany
    Clin Oral Investig 10:29-34. 2006
    ..new periodontal ligament, new cementum with inserting collagen fibers, and new bone). Within the limits of the present study, it can be concluded that OCHS may favor periodontal regeneration in acute-type intrabony periodontal defects...
  41. ncbi A histopathologic investigation on the effects of electrical stimulation on periodontal tissue regeneration in experimental bony defects in dogs
    Deniz Kaynak
    Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey
    J Periodontol 76:2194-204. 2005
    ..The present study was designed to examine histopathologically whether the application of an electrical field could demonstrate enhanced alveolar and cementum regeneration and modify tissue factors...
  42. ncbi Human histologic and clinical evaluation of recombinant human platelet-derived growth factor and beta-tricalcium phosphate for the treatment of periodontal intraosseous defects
    Heather K Ridgway
    University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Int J Periodontics Restorative Dent 28:171-9. 2008
    ..0-mg/mL sites demonstrated periodontal regeneration. This study provides proof of principle that 0.3 mg/mL and 1.0 mg/mL of rhPDGF-BB and beta-TCP can promote periodontal regeneration in human intraosseous periodontal defects...
  43. ncbi Differential expression and distribution of syndecan-1 and -2 in periodontal wound healing of the rat
    W Worapamorn
    Faculty of Dentistry, Prince of Songkhla University, Thailand
    J Periodontal Res 37:293-9. 2002
    ..The appearance of syndecan-1 may involve both cell-cell and cell-matrix interactions, while syndecan-2 showed a predilection to associate with cell-matrix interactions during hard tissue formation...
  44. ncbi Dens invaginatus in a primary molar: report of case
    Ece Koparal Eden
    Department of Pedodontics, Ege University, School of Dentistry, 35100 Bornova Izmir Turkey
    ASDC J Dent Child 69:49-53, 12. 2002
    ..Dentinal tissues were also irregular and had fewer and thinner tubules. This case of dens invaginatus in primary molar is an unusual case of the malformation being the only one in the literature...
  45. ncbi Human histology of new attachment after root coverage using subepithelial connective tissue graft
    M Goldstein
    Department of Periodontics, Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem, Israel 91010
    J Clin Periodontol 28:657-62. 2001
    ..New connective tissue attachment was also observed, including periodontal ligament. CONCLUSION: Biological width was comparable pre- and post-surgery, indicating a real gain in attachment of 3.9 mm...
  46. ncbi Participation of periodontal ligament cells with regeneration of alveolar bone
    J Isaka
    Department of Periodontology, Showa University Dental School, Tokyo, Japan
    J Periodontol 72:314-23. 2001
    ....
  47. ncbi Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane
    M Camelo
    Brazil Institute for Advanced Dental Studies, Belo Horizonte
    Int J Periodontics Restorative Dent 21:109-19. 2001
    ....
  48. ncbi Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs
    Seong-Ho Choi
    Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul
    J Periodontol 73:63-72. 2002
    ..rhBMP-2/ACS does not appear to have a significant effect on cementum regeneration and formation of a functional periodontal ligament in this model...
  49. ncbi Experimental tooth movement through mature and immature bone regenerates after distraction osteogenesis in dogs
    Norimichi Nakamoto
    Tohoku University Graduate School of Dentistry, Sendai, Japan
    Am J Orthod Dentofacial Orthop 121:385-95. 2002
    ..These results indicated that heavy force and early orthodontic tooth movement are not recommended when teeth are moved through regenerated bone created by distraction osteogenesis, to avoid tipping and severe root resorption...
  50. ncbi Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures
    G Thomadakis
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Eur J Oral Sci 107:368-77. 1999
    ..The composite expression of BMPs/OPs during periodontal tissue morphogenesis suggests that optimal therapeutic regeneration may entail the combined use of different BMPs/OPs...
  51. ncbi Periodontal regeneration following use of ABM/P-1 5: a case report
    Raymonda Yukna
    Department of Periodontics, Louisiana State University, School of Dentistry, New Orleans 70119 2799, USA
    Int J Periodontics Restorative Dent 22:146-55. 2002
    ..This case report fulfills the proof of principle that use of ABM/P-15 can result in periodontal regeneration on previously diseased root surfaces in humans...
  52. ncbi Root development in mice lacking functional tissue non-specific alkaline phosphatase gene: inhibition of acellular cementum formation
    W Beertsen
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Dent Res 78:1221-9. 1999
    ..It is concluded that TNAP represents an essential factor in mantle dentin mineralization and in the formation of acellular cementum...
  53. ncbi Extent and Severity Index based on assessments of radiographic bone loss
    P N Papapanou
    Department of Periodontology, Faculty of Odontology, , Gothenburg, Sweden
    Community Dent Oral Epidemiol 19:313-7. 1991
    ..The potential of the partial indices to predict full-mouth scores could be further enhanced via simple regression models. Such an evaluation should, ideally, be carried out in an independent subject sample...
  54. ncbi On the origin of intrinsic matrix of acellular extrinsic fiber cementum: studies on growing cementum pearls of normal and bisphosphonate-affected guinea pig molars
    Chantha K Jayawardena
    Department of Hard Tissue Engineering, Graduate School of Tokyo Medical and Dental University, Japan
    Eur J Oral Sci 110:261-9. 2002
    ....
  55. ncbi Effect of mechanical loading on periodontal cells
    D Pavlin
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, 78284 7910, USA
    Crit Rev Oral Biol Med 12:414-24. 2001
    ..This finding indicates that differential genetic responses to mechanical loading provide functional markers for distinction of the cementoblast and osteoblast phenotypes...
  56. ncbi Cellular events at the onset of physiological root resorption in rabbit deciduous teeth
    N Sahara
    Department of Oral Histology, Matsumoto Dental University, Shiojiri, Nagano, Japan
    Anat Rec 264:387-96. 2001
    ....
  57. ncbi Immunohistochemical identification of lymphatic vessels in the periodontium of equine cheek teeth
    Carsten Staszyk
    Institute of Anatomy, University of Veterinary Medicine Hannover, Germany
    J Vet Dent 22:227-32. 2005
    ..Lymphatic vessels were detected in all periodontal tissues except for the dental cementum. Lymphatic capillaries were most densely distributed in the gingiva compared to other tissues of the ..
  58. ncbi Models for the study of cementogenesis
    J A D'Errico
    Department of Periodontics Prevention Geriatrics, University of Michigan, Ann Arbor, USA
    Connect Tissue Res 33:9-17. 1995
    ..In contrast, the day 33 control molars demonstrated positive staining for BSP localized to root cementum, with normal formation of dentin...
  59. ncbi Growth factors regulate expression of mineral associated genes in cementoblasts
    N E Saygin
    Department of Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor 48109-1078, USA
    J Periodontol 71:1591-600. 2000
    ....
  60. ncbi Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins
    Noriyoshi Mizuno
    Department of Periodontal Medicine, Division of Frontier Medical Science, Programs for Biomedical Research, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Cell Biol Int 29:111-7. 2005
    ..Amelogenin mRNA expression could not be detected in any of the cells. These findings suggest that cultured ERM cells are characterized by expression of the cytokeratin 8, OPG and OPN genes...
  61. ncbi Tooth eruption and cementum formation in the Runx2/Cbfa1 heterozygous mouse
    S J Zou
    Department of Oral Cell Biology, ACTA, Van der Boechorststr 7, 1081 BT Amsterdam, The Netherlands
    Arch Oral Biol 48:673-7. 2003
    ..heterozygous mice (with one functional allele for Runx2/Cbfa1) exhibit similar changes in tooth eruption, and dental cementum formation as in CCD patients...
  62. ncbi Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering
    W V Giannobile
    Department of Periodontics Prevention Geriatrics and Center for Biorestoration of Oral Health, The University of Michigan, Ann Arbor 48109 1078, USA
    J Periodontol 72:815-23. 2001
    ..Recent advances in gene therapy offer the advantage of delivering recombinant proteins to tissues for extended periods of time in vivo...
  63. ncbi Incremental lines of dental cementum in biological age estimation
    R Jankauskas
    Department of Anatomy, Histology and Anthropology, Faculty of Medicine, Vilnius University, Ciurlionio 21, Vilnius LT 2009, Lithuania
    Homo 52:59-71. 2001
    ..All correlations had a similar standard error. Thus our assessment is less enthusiastic than in some past studies; it is suggested that the incremental lines rather have a similar use as other methods...
  64. ncbi Hard tissue-forming potential of stem/progenitor cells in human dental follicle and dental papilla
    Takahiro Yagyuu
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Arch Oral Biol 55:68-76. 2010
    ..The purpose of this study was to investigate these cells in human dental follicles and dental papillae at the crown-forming stage and compare their potential for hard tissue formation...
  65. ncbi Parathyroid hormone-related protein down-regulates bone sialoprotein gene expression in cementoblasts: role of the protein kinase A pathway
    H Ouyang
    Department of Periodontics Prevention Geriatrics, School of Dentistry, The University of Michigan, Ann Arbor 48109 1078, USA
    Endocrinology 141:4671-80. 2000
    ..In contrast, the activation of PKC promotes BSP gene expression. These data provide new insights into the molecular mechanisms involved in PTHrP regulation of cementogenesis...
  66. ncbi Loss of proliferation and differentiation capacity of aged human periodontal ligament stem cells and rejuvenation by exposure to the young extrinsic environment
    Wei Zheng
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Tissue Eng Part A 15:2363-71. 2009
    ....
  67. ncbi Utilization of MO6-G3 immortalized odontoblast cells in studies regarding dentinogenesis
    M MacDougall
    University of Texas Health Science Center at San Antonio, Dental School, Department of Pediatric Dentistry, 7703 Floyd Curl Drive, MC 7888, San Antonio, TX 78229 3900, USA
    Adv Dent Res 15:25-9. 2001
    ....
  68. ncbi Expression of type I collagen pro-alpha 2 chain mRNA in adult human permanent teeth as revealed by in situ hybridization
    P L Lukinmaa
    Department of Dental Radiology Oral Pathology, University of Helsinki, Finland
    J Dent Res 71:36-42. 1992
    ....
  69. ncbi Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype
    Ming Zhao
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Bone Miner Res 17:1441-51. 2002
    ..These results suggest that BMP-2 triggers follicle cells to differentiate toward a cementoblast/osteoblast phenotype and that the MAPK pathway is involved...
  70. ncbi Role of two mineral-associated adhesion molecules, osteopontin and bone sialoprotein, during cementogenesis
    R L MacNeil
    Department of Periodontics Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    Connect Tissue Res 33:1-7. 1995
    ..These findings collectively suggest that BSP and OPN are intimately involved in the sequence of cellular and molecular events accompanying cementogenesis...
  71. ncbi Localization of perlecan and heparanase in Hertwig's epithelial root sheath during root formation in mouse molars
    Azumi Hirata
    Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Histochem Cytochem 54:1105-13. 2006
    ..These findings suggest that perlecan removal is an important step for root and periodontal tissue formation. Heparanase secreted by the cells of HERS may contribute to root formation by degrading perlecan in the dental basement membrane...
  72. ncbi Defining the roots of cementum formation
    T Popowics
    Department of Oral Biology, University of Washington School of Dentistry, Seattle, Wash 98195, USA
    Cells Tissues Organs 181:248-57. 2005
    ..e. follicle cells, periodontal cells, and cementoblasts) and offer new directions to consider for clinical repair of periodontal defects...
  73. ncbi Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro
    C Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn 53175, Germany
    Calcif Tissue Int 78:98-102. 2006
    ..These real-time PCR results display molecular mechanisms in dental follicle precursor cells during osteogenic differentiation that are different from those in bone marrow-derived mesenchymal stem cells...
  74. ncbi Gene expression profiles of dental follicle cells before and after osteogenic differentiation in vitro
    Christian Morsczeck
    Department of Operative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin Oral Investig 13:383-91. 2009
    ..In conclusion, we present the first transcriptome of human DFCs before and after osteogenic differentiation. This study sheds new light on the complex mechanism of osteogenic differentiation in DFCs...
  75. ncbi Immunohistochemical detection of matrix metalloproteinase-1 in the periodontal ligament of equine cheek teeth
    M Warhonowicz
    Institute of Anatomy, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Tissue Cell 39:369-76. 2007
    ..Specimens containing the PDL interposed between the dental cementum and the alveolar bone were taken from nine Warmblood horses at three designated horizontal levels: ..
  76. ncbi Expression of vascular endothelial growth factor in cultured human dental follicle cells and its biological roles
    Xue peng Chen
    Department of Orthodontics, Qindu Stomatological College, Fourth Military Medical University, Xi an 710032, China
    Acta Pharmacol Sin 28:985-93. 2007
    ..To investigate the expression of vascular endothelial growth factor (VEGF) in cultured human dental follicle cells (HDFC), and to examine the roles of VEGF in the proliferation, differentiation, and apoptosis of HDFC in vitro...
  77. ncbi Isolation of murine cementoblasts: unique cells or uniquely-positioned osteoblasts?
    R L MacNeil
    Department of Periodontics Prevention Geriatrics, University of Michigan, Ann Arbor 48109 1078, USA
    Eur J Oral Sci 106:350-6. 1998
    ....
  78. ncbi Bone morphogenetic protein-7 enhances cementoblast function in vitro
    Sema S Hakki
    Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya, Turkey
    J Periodontol 81:1663-74. 2010
    ..We hypothesized that BMP-7 would regulate mineralized tissue-associated genes in cementoblasts and influence the expression profile of genes associated with cementoblast extracellular matrix (ECM) and cell adhesion molecules (CAMs)...
  79. ncbi Should cementoblasts express alkaline phosphatase activity? Preliminary study of rat cementoblasts in vitro
    J Gao
    Department of Dentistry, The University of Queensland, Brisbane, Australia
    J Periodontol 70:951-9. 1999
    ..Whether cementoblasts express alkaline phosphatase (ALP) activity in vivo and in vitro remains to be determined...
  80. ncbi Immunolocalization of a human cementoblastoma-conditioned medium-derived protein
    H Arzate
    Laboratorio de Biologia Celular y Molecular, División de Estudios de Posgrado e Investigación, Facultad de Odontologia, UNAM, Cd Universitaria, 04510, Mexico DF, Mexico
    J Dent Res 81:541-6. 2002
    ..These findings indicate that CP identifies potential cementoblast progenitor cells, is immunologically related to CAP species, and serves as a biological marker for cementum...
  81. ncbi Self assembled bi-functional peptide hydrogels with biomineralization-directing peptides
    Mustafa Gungormus
    Materials Science and Engineering, University of Washington, Seattle, WA, USA
    Biomaterials 31:7266-74. 2010
    ..Control hydrogels, prepared by peptides either lacking the mineral-directing portion or reversing its sequence, indicated that the heptapeptide is necessary and its actions are sequence specific...
  82. ncbi Crystallite arrangement of hydroxyapatite microcrystals in human tooth cementum as revealed by electron paramagnetic resonance (EPR)
    U Skaleric
    Center for Dental Research, Jozef Stefan Institute, University of Ljubljana, Slovenia
    Eur J Oral Sci 106:365-7. 1998
    Human dental cementum was analyzed by electron paramagnetic resonance (EPR). The measured EPR powder spectra of gamma-irradiated cementum resembled those of gamma-irradiated enamel...
  83. ncbi Substance removal on teeth with and without calculus using 308 nm XeCl excimer laser radiation. An in vitro investigation
    M Folwaczny
    Department of Operative Dentistry and Periodontology, Ludwig Maximilians University, Munich, Germany
    J Clin Periodontol 26:306-12. 1999
    ..67 (+/-21.05) microm with laser treatment at an energy density of 5.0 J/cm2. While no ablation of dental cementum was detectable after irradiating root surfaces without calculus at 1...
  84. ncbi [Histological evaluation on repair of furcation perforation in dogs using mineral trioxide aggregate]
    Ya Qin Zhu
    Department of Oral Medicine, Ninth People s Hospital, Shanghai Second Medical University, Shanghai 200011, China
    Shanghai Kou Qiang Yi Xue 12:47-50. 2003
    ..To investigate histological response to immediate repair of different sizes of furcation perforation using MTA, Dycal and GIC...
  85. ncbi Estimation of the specific surface area of apatites in human mineralized tissues using 31P MAS NMR
    Joanna Kolmas
    Department of Inorganic and Analytical Chemistry, Medical University of Warsaw, ul Banacha 1, 02 097 Warszawa, Poland
    Solid State Nucl Magn Reson 32:53-8. 2007
    Specific surface areas of apatites in whole human mineralized tissues were estimated from (31)P MAS NMR linewidths: 77 m(2)g(-1) for enamel and 94 m(2)g(-1) for dentin, dental cementum and cortical bone.
  86. ncbi Characterization of recombinant human cementum protein 1 (hrCEMP1): primary role in biomineralization
    Eduardo Villarreal-Ramírez
    Laboratorio de Biología Periodontal y Tejidos Mineralizados, Facultad de Odontologia, UNAM, Mexico DF, Mexico
    Biochem Biophys Res Commun 384:49-54. 2009
    ..These features make CEMP1 a very good candidate for biotechnological applications in order to achieve cementum and/or bone regeneration...
  87. ncbi Human cementoblasts express enamel-associated molecules in vitro and in vivo
    J Nunez
    Facultad de Odontologa, Universidad Complutense de Madrid, Espana
    J Periodontal Res 45:809-14. 2010
    ....
  88. ncbi A simple fluorescence labeling method to visualize the three-dimensional arrangement of collagen fibers in the equine periodontal ligament
    Carsten Staszyk
    Department of Anatomy, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Ann Anat 186:149-52. 2004
    ..This contributed to demonstration of the complex architecture of the PDL, i. e. the varying sizes of the fiber bundles, their specific spatial alignment, and the entheses to the dental cementum.
  89. ncbi Use of microarrays to find novel regulators of periodontal ligament fibroblast differentiation
    Thomas E Lallier
    Department of Cell Biology and Anatomy, Center of Excellence in Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Science Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Cell Tissue Res 327:93-109. 2007
    ....
  90. ncbi A method to isolate, purify, and characterize human periodontal ligament stem cells
    Krzysztof Mrozik
    Mesenchymal Stem Cell Group, Division of Hematology, Institute of Medical and Veterinary Science Hanson Institute, Adelaide, Australia
    Methods Mol Biol 666:269-84. 2010
    ....
  91. ncbi Matrix Gla protein inhibition of tooth mineralization
    N R Kaipatur
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada H3A 2B2
    J Dent Res 87:839-44. 2008
    ..Acellular cementum was lacking in Col1a1-Mgp teeth, and unmineralized osteodentin formed within the pulp. These results strengthen the view that bone and tooth mineralization is critically regulated by mineralization inhibitors...
  92. ncbi 17beta-estradiol promotes cementoblast proliferation and cementum formation in experimental periodontitis
    Javier Nunez
    Institute of Molecular Biology and Genetics, University of Valladolid, and Spanish Research Council, Valladolid, Spain
    J Periodontol 81:1064-74. 2010
    ..With this goal, we investigated the effects of low concentrations of 17beta-estradiol on human cementoblast proliferation and its possible regenerative potential in vivo...
  93. ncbi Familial hypophosphatemic rickets
    A Sattur
    Department of Oral Medicine and Radiology, SDM College of Dental Sciences and Hospital, Dharwar, Karnataka, India
    J Indian Soc Pedod Prev Dent 28:302-6. 2010
    ..In the present case, radiographic aspects of oral and systemic manifestations of familial hypophosphatemic rickets are highlighted...
  94. ncbi A novel bioactive three-dimensional beta-tricalcium phosphate/chitosan scaffold for periodontal tissue engineering
    Feng Liao
    Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, People s Republic of China
    J Mater Sci Mater Med 21:489-96. 2010
    ..The protein expression of ALP and OPN was up-regulated in the composite scaffold. Therefore, it was suggested that the composite scaffold could promote the differentiation of HPLCs towards osteoblast and cementoblast phenotypes...
  95. ncbi Physical properties of root cementum: part 20. Effect of fluoride on orthodontically induced root resorption with light and heavy orthodontic forces for 4 weeks: a microcomputed tomography study
    Ersan Ilsay Karadeniz
    Department of Orthodontics, University of Sydney, Sydney, Australia
    Am J Orthod Dentofacial Orthop 140:e199-210. 2011
    ..The aim of this study was to investigate the effect of high and low amounts of fluoride intake from birth on orthodontically induced inflammatory root resorption under light (25 g) and heavy (225 g) force applications...
  96. ncbi Regional odontodysplasia: morphological, ultrastructural, and immunohistochemical features of the affected teeth, connective tissue, and odontogenic remnants
    Roman Carlos
    Department of Pathology, Centro Clínico de Cabeza y Cuello, Guatemala City, Guatemala
    J Dent Child (Chic) 75:144-50. 2008
    ..The purpose of this study was to describe the ultrastructural characteristics of the affected teeth as well as the immunohistochemical features of the soft tissue associated with 2 cases of regional odontodysplasia...
  97. ncbi Has dental caries prevalence some connection with caries index values in adults?
    M Larmas
    University Hospital of Oulu, University of Oulu, Oulu, Finland
    Caries Res 44:81-4. 2010
    ..Combining the individual parameters of Oral Health Surveys and diseases of ICD-10, and analyzing the mean value of each parameter separately, will give a precise picture of dental health at different ages...
  98. ncbi Apical tooth germ cell-conditioned medium enhances the differentiation of periodontal ligament stem cells into cementum/periodontal ligament-like tissues
    Z H Yang
    Department of Orthodontics, School of Stomatology, Fourth Millitary Medical University, 145 West Changle Road, Xi an, Shaanxi, China
    J Periodontal Res 44:199-210. 2009
    ..The aim of this study was to investigate the biological effect of conditioned medium from developing apical tooth germ cells (APTG-CM) on the differentiation and cementogenesis of PDLSCs both in vitro and in vivo...
  99. ncbi Adsorption of follicular dendritic cell-secreted protein (FDC-SP) onto mineral deposits. Application of a new stable gene expression system
    Tamayuki Shinomura
    Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    J Biol Chem 283:33658-64. 2008
    ..These results suggest that FDC-SP may play an important role, adsorbing onto the surface of cementum and alveolar bone adjacent to periodontal ligament and onto tooth surface at the gingival crevice...
  100. ncbi Microstructure of dental hard tissues and bone in the Tuatara dentary, Sphenodon punctatus (Diapsida: Lepidosauria: Rhynchocephalia)
    J A Kieser
    Faculty of Dentistry, University of Otago, Dunedin, New Zealand
    Front Oral Biol 13:80-5. 2009
    ..These were spaced appropriately for monthly lunar growth bands, which would explain the basis of the banding pattern observed in the fast growing basal bone beneath the Meckel's canal...
  101. ncbi One-year clinical evaluation of a two-step self-etch adhesive with and without additional enamel etching technique in cervical lesions
    E Ozel
    Operative Dentistry, Faculty of Dentistry, The University of Kocaeli, Kocaeli, Turkey
    Aust Dent J 55:156-61. 2010
    ..The aim of this study was to determine the clinical performance of a two-step self-etch adhesive with and without additional enamel etching technique to advanced non-carious cervical sclerotic lesions...

Research Grants88

  1. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2001
    ..g., hypophosphatasia, cementomas, and Paget's associated hypercementosis, and for designing effective clinical procedures for regeneration of periodontal tissues, as well as other mineralized tissues. ..
  2. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2007
    ..abstract_text> ..
  3. Key Modulators of Cementogenesis
    Martha J Somerman; Fiscal Year: 2010
    ....
  4. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMENTOGENESIS
    Martha Somerman; Fiscal Year: 2006
    ..This information is necessary for designing regenerative therapies based on sound biological principles. ..
  5. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2006
    ..In this revision, more experimental details have been provided. ..
  6. Primary Genes Promoting Cementoblast Differentiaton
    Sotirios Tetradis; Fiscal Year: 2007
    ..We anticipate that Nur77, egr1, and mkp1 will be key mediators of cementoblast differentiation. These studies will contribute to our understanding of the molecular signals that regulate cementoblast function. ..
  7. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2003
    ..The data generated in this study will also provide information related to the regulation of root formation and possible ways to improve the diagnosis, treatment, and prognosis of tooth loss due to aging or periodontal diseases. ..
  8. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2009
    ..abstract_text> ..
  9. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
    ..The use of AAV-TNF: Fc has significant potential as a therapeutic regimen to treat aggressive periodontitis that is governed by an exuberant inflammatory response. ..
  10. Tissue Engineering and Regeneration
    Paul Krebsbach; Fiscal Year: 2007
    ..The University of Michigan recognizes the importance of quality training programs and is committed to training oral scientists as independent researchers and life-long learners. ..
  11. Ninth International Conference on the Chemistry and Biology of Mineralized Tissue
    Paul Krebsbach; Fiscal Year: 2007
    ..The ensuing "cross pollenization" of perspective and expertise is the ideal venue to enhance the process of discovery in this important field. ..
  12. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
    ..Mouse models mimic the human defects and can be used to correlate individual gene mutations with appropriate clinical intervention. ..
  13. BONE MARROW STROMAL CELLS FOR SKELETAL REGENERATION
    Paul Krebsbach; Fiscal Year: 2005
    ..The information gained from this study will provide an essential prerequisite for the development of regenerative approaches that utilize bone marrow stromal cells for gene-and cell-based therapies. ..
  14. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
    ..Mouse models mimic the human defects and can be used to correlate individual gene mutations with appropriate clinical intervention. ..
  15. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 1993
    ....
  16. Materials/Biologic Constructs for Skeletal Regeneration
    Paul Krebsbach; Fiscal Year: 2002
    ..Bone and cartilage formation in our anatomic-specific designed bioengineered materials will facilitate innovative strategies for the reconstruction of human joints. ..
  17. MOLECULAR REGULATION OF PERIODONTIUM FORMATION
    Margarita Zeichner David; Fiscal Year: 2009
    ..Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration. ..
  18. MOLECULAR REGULATION OF PERIODONTIUM FORMATION
    Margarita Zeichner David; Fiscal Year: 2010
    ..Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration. ..
  19. Biomimetics for Dentin Regeneration
    R Rutherford; Fiscal Year: 2003
    ..If successful these experiments could lead to efficacy tests in non-human primate models of reparative dentinogenesis (Phase II), human clinical trials and commercialization. ..
  20. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 2002
    ....
  21. DETERMINANTS OF ROOT RESORPTION DUE TO ORTHODONTIC MOVEMENT
    Margarita Zeichner David; Fiscal Year: 2005
    ....
  22. CEMENTOGENESIS--ROLE OF HERTWIGS EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2001
    ....
  23. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2006
    ..Although rare, individuals with root agenesis have been documented. ..
  24. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2007
    ..A better understanding of the health-related benefits and problems associated with environmental fluoride will lead to more informed policy decisions and fundamental knowledge about the impact of this environmental agent. ..
  25. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2006
    ..3) to evaluate LRAP for signal function in vivo and in vitro; and (4) to ascertain additional consequences of absence of amelogenin in maturative ameloblasts, in reparative dentin and during accelerated eruption ..