dental cementum

Summary

Summary: The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)

Top Publications

  1. ncbi Treatment of furcation defects with an allograft-alloplast-tetracycline composite bone graft combined with GTR: human histologic evaluation of a case report
    Randall J Harris
    Int J Periodontics Restorative Dent 22:381-7. 2002
  2. ncbi Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting
    David L Cochran
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1269-81. 2003
  3. ncbi Detection of dentin sialoprotein in rat periodontium
    Otto Baba
    Department of Endodontics and Periodontics, The University of Texas Houston Health Science Center Dental Branch, Houston, Texas, USA
    Eur J Oral Sci 112:163-70. 2004
  4. pmc The biomechanical characteristics of the bone-periodontal ligament-cementum complex
    Sunita P Ho
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California San Francisco, San Francisco, CA 94143, USA
    Biomaterials 31:6635-46. 2010
  5. pmc Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin
    Sunita P Ho
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, UCSF, 707 Parnassus Avenue, San Francisco, CA 94143 0758, USA
    Acta Biomater 5:707-18. 2009
  6. pmc Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse
    H Fong
    Department of Materials Science and Engineering, University of Washington, Seattle, WA, USA
    J Periodontol 80:1348-54. 2009
  7. ncbi Advances in defining regulators of cementum development and periodontal regeneration
    Brian L Foster
    Department of Periodontics, School of Dentistry, University of Washington, Seattle, Washington 98195, USA
    Curr Top Dev Biol 78:47-126. 2007
  8. ncbi The developmental biology of cementum
    T G Diekwisch
    Allan G Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, 60612, USA
    Int J Dev Biol 45:695-706. 2001
  9. ncbi Role of Hertwig's epithelial root sheath cells in tooth root development
    Margarita Zeichner-David
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California 90033, USA
    Dev Dyn 228:651-63. 2003
  10. ncbi Are cementoblasts a subpopulation of osteoblasts or a unique phenotype?
    D D Bosshardt
    Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Berne, Freiburgstrasse 7, CH 3010 Berne, Switzerland
    J Dent Res 84:390-406. 2005

Research Grants

  1. REGULATION OF PERIODONTAL CELLS BY CEMENTUM COMPONENTS
    A Narayanan; Fiscal Year: 2000
  2. REGULATION OF PERIODONTAL CELLS BY CEMENTUM COMPONENTS
    A Narayanan; Fiscal Year: 2001
  3. REGULATION OF PERIODONTAL CELLS BY CEMENTUM COMPONENTS
    A Narayanan; Fiscal Year: 2000
  4. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2001
  5. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2000
  6. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2001
  7. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 1999
  8. TISSUE INTERACTIONS IN ROOT DEVELOPMENT
    Huw Thomas; Fiscal Year: 1990
  9. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2007
  10. Key Modulators of Cementogenesis
    Martha J Somerman; Fiscal Year: 2010

Detail Information

Publications190 found, 100 shown here

  1. ncbi Treatment of furcation defects with an allograft-alloplast-tetracycline composite bone graft combined with GTR: human histologic evaluation of a case report
    Randall J Harris
    Int J Periodontics Restorative Dent 22:381-7. 2002
    ..In this study, regeneration of a furcation defect in a human was documented with histology...
  2. ncbi Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting
    David L Cochran
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1269-81. 2003
    ..The goal of this study was to evaluate periodontal regeneration in intrabony defects of various sizes treated with a combination of enamel matrix proteins and autogenous bone graft...
  3. ncbi Detection of dentin sialoprotein in rat periodontium
    Otto Baba
    Department of Endodontics and Periodontics, The University of Texas Houston Health Science Center Dental Branch, Houston, Texas, USA
    Eur J Oral Sci 112:163-70. 2004
    ..Together, these observations suggest that DSP is involved in formation of the periodontium as well as tooth structures...
  4. pmc The biomechanical characteristics of the bone-periodontal ligament-cementum complex
    Sunita P Ho
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California San Francisco, San Francisco, CA 94143, USA
    Biomaterials 31:6635-46. 2010
    ..2-9.6 GPa) and PDL-cementum (E(r) range for cementum: 1.1-8.3 GPa), which was related to the macro-scale function of the bone-tooth complex...
  5. pmc Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin
    Sunita P Ho
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, UCSF, 707 Parnassus Avenue, San Francisco, CA 94143 0758, USA
    Acta Biomater 5:707-18. 2009
    ..5+/-0.7 GPa). The resulting data illustrated that the extensions of observations made from animal models to humans should be justified with substantial and equivalent comparison of data across age ranges (life spans) of mammalian species...
  6. pmc Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse
    H Fong
    Department of Materials Science and Engineering, University of Washington, Seattle, WA, USA
    J Periodontol 80:1348-54. 2009
    ..Here, we report a developmental study of tooth root formation in Hyp mouse molars, focusing on dentin and cementum...
  7. ncbi Advances in defining regulators of cementum development and periodontal regeneration
    Brian L Foster
    Department of Periodontics, School of Dentistry, University of Washington, Seattle, Washington 98195, USA
    Curr Top Dev Biol 78:47-126. 2007
    ..Cells, genes, and proteins regulating root development are reviewed in a question-answer format in order to highlight areas of progress as well as areas of remaining uncertainty that warrant further study...
  8. ncbi The developmental biology of cementum
    T G Diekwisch
    Allan G Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, 60612, USA
    Int J Dev Biol 45:695-706. 2001
    ..Our studies in conjunction with our literature review together confirmed the classical theory of cementum as a dental follicle derived connective tissue that forms subsequent to HERS disintegration...
  9. ncbi Role of Hertwig's epithelial root sheath cells in tooth root development
    Margarita Zeichner-David
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California 90033, USA
    Dev Dyn 228:651-63. 2003
    ..These studies suggest that the acellular and cellular cementum are synthesized by two different types of cells, the first one by HERS-derived cementoblasts and the later by neural crest-derived cementoblasts...
  10. ncbi Are cementoblasts a subpopulation of osteoblasts or a unique phenotype?
    D D Bosshardt
    Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Berne, Freiburgstrasse 7, CH 3010 Berne, Switzerland
    J Dent Res 84:390-406. 2005
    ..The role of enamel matrix proteins in cementoblast and osteoblast differentiation and their potential use for tissue engineering are discussed...
  11. ncbi Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype
    Ming Zhao
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Bone Miner Res 17:1441-51. 2002
    ..These results suggest that BMP-2 triggers follicle cells to differentiate toward a cementoblast/osteoblast phenotype and that the MAPK pathway is involved...
  12. pmc The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition
    B L Foster
    Department of Periodontics, University of Washington School of Dentistry, Seattle, Wash 98195, USA
    Cells Tissues Organs 194:382-405. 2011
    ..Studies here aimed to define the role of ANK in root and cementum by analyzing tooth development in Ank knock-out (KO) mice versus wild type...
  13. ncbi Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis
    Fernanda Boabaid
    Department of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195 7444, USA
    J Periodontol 75:1126-36. 2004
    ..Here, we focused on determining whether or not leucine-rich amelogenin peptide (LRAP), translated from an alternatively spliced amelogenin RNA, altered cementoblast behavior...
  14. pmc Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia
    M D McKee
    Faculty of Dentistry, and Department of Anatomy and Cell Biology, McGill University, Strathcona Anatomy and Dentistry Bldg, 3640 University Street, Montreal, Quebec, Canada
    J Dent Res 90:470-6. 2011
    ....
  15. ncbi Regeneration of periodontal tissues: cementogenesis revisited
    Margarita Zeichner-David
    Centre for Craniofacial Molecular Biology, School of Dentistry, Division of Surgical, Therapeutics and Bioengineering Sciences, University of Southern California, Los Angeles, California, USA
    Periodontol 2000 41:196-217. 2006
  16. ncbi Amelogenin: a potential regulator of cementum-associated genes
    Hema L Viswanathan
    Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    J Periodontol 74:1423-31. 2003
    ..Amelogenins have been reported to induce expression of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate the activity of mesenchyme-derived cells...
  17. ncbi Root development in mice lacking functional tissue non-specific alkaline phosphatase gene: inhibition of acellular cementum formation
    W Beertsen
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Dent Res 78:1221-9. 1999
    ..It is concluded that TNAP represents an essential factor in mantle dentin mineralization and in the formation of acellular cementum...
  18. ncbi Expression of bone associated markers by tooth root lining cells, in situ and in vitro
    J A D'Errico
    Department of Periodontics Prevention Geriatrics and Pharmacology, University of Michigan, Ann Arbor, USA
    Bone 20:117-26. 1997
    ..These procedures have provided a means to obtain root-lining cells in vitro that can now be cloned and used for studies directed at determining the properties of root-lining cells, or cementoblasts, in vitro...
  19. ncbi Role of two mineral-associated adhesion molecules, osteopontin and bone sialoprotein, during cementogenesis
    R L MacNeil
    Department of Periodontics Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    Connect Tissue Res 33:1-7. 1995
    ..These findings collectively suggest that BSP and OPN are intimately involved in the sequence of cellular and molecular events accompanying cementogenesis...
  20. doi Hepatocyte growth factor stimulates root growth during the development of mouse molar teeth
    H Sakuraba
    Division of Orthodontics, Department of Developmental Oral Health Science, Iwate Medical University, Morioka, Iwate, Japan
    J Periodontal Res 47:81-8. 2012
    ..As hepatocyte growth factor (HGF) is one of the mediators of epithelial-mesenchymal interactions in rodent tooth, the objective of this study was to examine the effects of HGF on the root development of mouse molars...
  21. doi Constitutive stabilization of ß-catenin in the dental mesenchyme leads to excessive dentin and cementum formation
    Tak Heun Kim
    Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and BK21 Program, Chonbuk National University School of Dentistry, Jeonju, South Korea
    Biochem Biophys Res Commun 412:549-55. 2011
    ..Local modulation of Wnt/ß-catenin signaling has therapeutic potential to improve the regeneration of dentin and periodontium...
  22. pmc Methods for studying tooth root cementum by light microscopy
    Brian L Foster
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Int J Oral Sci 4:119-28. 2012
    ..Histological and immunohistochemical approaches provide insight on developmental biology of cementum...
  23. pmc Central role of pyrophosphate in acellular cementum formation
    Brian L Foster
    Laboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e38393. 2012
    ..To elucidate the role of PP(i) in cementum formation, we analyzed root development in knock-out ((-/-)) mice featuring PP(i) dysregulation...
  24. doi Structure and mechanical properties of Ank/Ank mutant mouse dental tissues--an animal model for studying periodontal regeneration
    H Fong
    Materials Science and Engineering, University of Washington, Seattle, WA, USA
    Arch Oral Biol 54:570-6. 2009
    ..In conclusion, these data suggest that this animal model can be utilized for studies focused on defining mechanisms to promote cementum formation without loss of mechanical integrity...
  25. pmc Bones, teeth, and genes: a genomic homage to Harry Sicher's "Axial Movement of Teeth"
    Sean Holliday
    Department of Orthodontics, University of Illinois at Chicago, College of Dentistry, Chicago, Illinois 60612, USA
    World J Orthod 6:61-70. 2005
    ..The model of the unopposed rodent molar was used to study the morphologic and genetic mechanisms of tooth eruption...
  26. ncbi On the origin of intrinsic matrix of acellular extrinsic fiber cementum: studies on growing cementum pearls of normal and bisphosphonate-affected guinea pig molars
    Chantha K Jayawardena
    Department of Hard Tissue Engineering, Graduate School of Tokyo Medical and Dental University, Japan
    Eur J Oral Sci 110:261-9. 2002
    ....
  27. ncbi Alkaline phosphatase activity in human periodontal ligament: age effect and relation to cementum growth rate
    T Van den Bos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Periodontal Res 34:1-6. 1999
    ..The activity of the enzyme in the PDL correlated positively with the yearly cementum thickness increment as calculated from data published previously...
  28. pmc Molecular regulatory mechanism of tooth root development
    Xiao Feng Huang
    Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    Int J Oral Sci 4:177-81. 2012
    ..This review summarizes our current understanding of the signaling cascades and mechanisms involved in root development. It also sets the stage for de novo tooth regeneration...
  29. ncbi Matrix Gla protein inhibition of tooth mineralization
    N R Kaipatur
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada H3A 2B2
    J Dent Res 87:839-44. 2008
    ..Acellular cementum was lacking in Col1a1-Mgp teeth, and unmineralized osteodentin formed within the pulp. These results strengthen the view that bone and tooth mineralization is critically regulated by mineralization inhibitors...
  30. ncbi Cementum: a phosphate-sensitive tissue
    F H Nociti
    Department of Periodontics Prevention Geriatrics, School of Dentistry, Rm 3310M Dental, University of Michigan, 1011 N University Avenue, Ann Arbor, MI 48109 1078, USA
    J Dent Res 81:817-21. 2002
    ..This information may prove valuable in attempts to design successful therapies for regenerating periodontal tissues...
  31. pmc Modulation of phosphate/pyrophosphate metabolism to regenerate the periodontium: a novel in vivo approach
    Thaisângela L Rodrigues
    Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry, Campinas State University, Piracicaba, SP, Brazil
    J Periodontol 82:1757-66. 2011
    ..We hypothesized that, besides affecting cementum formation, decreased extracellular PP(i) levels in Ank KO mice would also impact cementum regeneration...
  32. ncbi Exploring the origins of cementoblasts and their trigger factors
    Janice E Berry
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Connect Tissue Res 44:97-102. 2003
    ..Such dissimilarities in responsiveness associated with cell type may need to be considered when designing regenerative therapies...
  33. pmc Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system
    Narita L Leong
    Division of Biomaterials and Bioengineering, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 7:e35980. 2012
    ..5 to 4 months), growth (4 to 10 months), followed by a senescent phase (10 to 15 months), from which deviations due to experimentally induced perturbations can be effectively investigated...
  34. pmc The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium
    Sunita P Ho
    Department of Preventive and Restorative Dental Sciences, Division of Biomaterials and Bioengineering, University of California, San Francisco, CA 94143 0758, USA
    Biomaterials 28:5238-45. 2007
    ..Thus, through variations in concentrations of basic constituents, distinct regions with characteristic structures and graded properties allow for attachment and the load bearing characteristics of a tooth...
  35. ncbi Ultrastructure and nanomechanical properties of cementum dentin junction
    S P Ho
    Department of Preventive and Restorative Dental Sciences, Division of Biomaterials and Bioengineering, University of California San Francisco, Box 0758, D 2246, San Francisco, California 94143, USA
    J Biomed Mater Res A 68:343-51. 2004
    ..The lower mechanical properties of the CDJ may make it possible for it to redistribute occlusal loads to the alveolar bone...
  36. pmc Genetic evidence for the vital function of Osterix in cementogenesis
    Zhengguo Cao
    The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST, Ministry of Education, Department of Periodontology, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    J Bone Miner Res 27:1080-92. 2012
    ....
  37. ncbi Local properties of a functionally graded interphase between cementum and dentin
    Sunita P Ho
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California San Francisco, 707 Parnassus Avenue, 94143, USA
    J Biomed Mater Res A 70:480-9. 2004
    ..Hence, cementum, dentin, and the interphase can be classified as a functionally graded dental tissue within the root of a tooth...
  38. ncbi Recovery of stem cells from cryopreserved periodontal ligament
    B M Seo
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Dent Res 84:907-12. 2005
    ....
  39. pmc Structure, chemical composition and mechanical properties of coronal cementum in human deciduous molars
    Sunita P Ho
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, UCSF, San Francisco, CA 94143 0758, USA
    Dent Mater 25:1195-204. 2009
    ..It was hypothesized that the coronal cementum containing collagen forms a weak junction with enamel unlike the well integrated DEJ and CDJ...
  40. ncbi Cementum and dentin in hypophosphatasia
    T Van den Bos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, Universiteit van Amsterdam, and Vrije Universiteit, Louwesweg 1, 1066 EA Amsterdam, The Netherlands
    J Dent Res 84:1021-5. 2005
    ..Our findings suggest that mineralization of dentin is less likely to be under the influence of the inhibitory action of pyrophosphate than mineralization of cementum...
  41. doi Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo
    Shinsuke Fujii
    Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    J Cell Physiol 215:743-9. 2008
    ..These data suggest that cell line 1-11 was derived from a progenitor/stem cell present in the PDL and should be very useful for studying the biology and regeneration of human periodontium...
  42. doi Cementum- and periodontal ligament-like tissue formation by dental follicle cell sheets co-cultured with Hertwig's epithelial root sheath cells
    Yudi Bai
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, China
    Bone 48:1417-26. 2011
    ..These results indicate that the DFC sheets induced by HERS cells are able to produce periodontal tissues through epithelial-mesenchymal interactions. Therefore, DFC sheets may be useful in the field of periodontium regeneration...
  43. pmc Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells
    Hai Zhang
    Department of Restorative Dentistry, School of Dentistry, University of Washington, Seattle, WA 98195, USA
    Arch Oral Biol 55:417-25. 2010
    ..The goal of this study was to determine if LAMP-1 serves as a cell surface binding site for full length amelogenin on tooth root/periodontium associated mesenchymal cells...
  44. doi Periodontal regeneration using engineered bone marrow mesenchymal stromal cells
    Yi Yang
    Laboratory of Periodontal Biology, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia, 2199 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Biomaterials 31:8574-82. 2010
    ..Finally, donor-derived BM-MSCs were found integrated in newly formed bone, cementum and periodontal ligament, suggesting that they can directly contribute to the regeneration of cells of these tissues...
  45. pmc Differentiation of neural-crest-derived intermediate pluripotent progenitors into committed periodontal populations involves unique molecular signature changes, cohort shifts, and epigenetic modifications
    Smit Jayant Dangaria
    Brodie Laboratory for Craniofacial Genetics, University of Illinois, Chicago, IL, USA
    Stem Cells Dev 20:39-52. 2011
    ....
  46. doi Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells
    Hyun Sung Jung
    Department of Oral Histology Developmental Biology and Dental Research Institute, BK21 Project, School of Dentistry, Seoul National University, 28 YeonGun Dong, Chongro Gu, Seoul 110 749, Korea
    J Mol Histol 42:227-35. 2011
    ....
  47. pmc Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets
    L Ye
    Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Dent Res 87:624-9. 2008
    ..We propose that defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice...
  48. ncbi [Preservation of alveolar bone of un-restorable traumatized maxillary incisors for future]
    I Levin
    Dept of Restorative Dentistry, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Refuat Hapeh Vehashinayim 21:54-9, 101-2. 2004
    ..The alternative treatment of surgical extraction of an ankylosed tooth often leads to considerable bone loss and reduced bone volume in the oro-facial dimension. This may later necessitate an augmentation procedure...
  49. ncbi Interrelation between endodontic status, pathologic cemental granules and periodontal ligament adhering to the root of extracted teeth
    Yango Pohl
    Department of Oral Surgery, University of Bonn, Bonn, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:127-33. 2007
    ..To evaluate if the endodontic status has influence on the adherence of periodontal ligament (PDL) to extracted teeth and if the presence of "pathologic granules" is correlated to the endodontic status and/or the amount of adhering PDL...
  50. ncbi Periodontal repair in surgically created intrabony defects in dogs: influence of the number of bone walls on healing response
    Chang Sung Kim
    Department of Periodontology, Research Institute for Periodontal Regeneration, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 75:229-35. 2004
    ..The objective of this study was to histologically evaluate periodontal healing following flap surgery in intrabony periodontal defects to determine the influence of the number of bone walls on periodontal regeneration...
  51. ncbi Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain. A histologic study
    N Donos
    Department of Periodontology, Royal Dental College, University of Aarhus, Denmark
    J Clin Periodontol 30:1061-8. 2003
    ..However, no histological studies are available investigating the effect of EMD in the treatment of degree III furcation involvements...
  52. ncbi Effect of early membrane removal on regeneration of Class II furcation defects in dogs
    Guilherme O Macedo
    Department of Surgery, Oral Maxillo Facial Traumatology and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    J Periodontol 77:46-53. 2006
    ..This study evaluated the influence of early removal of an expanded polytetrafluoroethylene (ePTFE) membrane on periodontal regeneration...
  53. ncbi Possible role of dentin matrix in region-specific deposition of cellular and acellular extrinsic fibre cementum
    Yoshiro Takano
    Division of Biostructural Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Electron Microsc (Tokyo) 52:573-80. 2003
    ..The timing of mineralization of mantle dentin matrix might be the key determinant of the types of the cementum deposited on the growing root surface...
  54. ncbi Alveolar bone loss and aging: a model for the study in mice
    Elken G Rivaldo
    Geriatrics and Gerontology Institute, Pontifical Catholic University, Porto Alegre, Rio Grande do Sul, Brazil
    J Periodontol 76:1966-71. 2005
    ..Several animal studies have shown a positive correlation between aging and alveolar bone loss (ABL). The purpose of this study was to develop a model for the study of ABL in mice and aging...
  55. ncbi Participation of periodontal ligament cells with regeneration of alveolar bone
    J Isaka
    Department of Periodontology, Showa University Dental School, Tokyo, Japan
    J Periodontol 72:314-23. 2001
    ....
  56. ncbi Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: short-, medium- and long-term healing
    Filippo Graziani
    Department of Periodontology, Eastman Dental Institute, University College London, London, UK
    J Clin Periodontol 32:905-14. 2005
    ..To describe periodontal wound healing in dehiscence-type defects following guided tissue re-generation (GTR) therapy...
  57. ncbi Pattern of mineralization after regenerative periodontal therapy with enamel matrix proteins
    Dieter D Bosshardt
    Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Berne, Berne, Switzerland
    Eur J Oral Sci 114:225-31; discussion 254-6, 381-2. 2006
    ..The mineralization pattern mostly resembled that found in bone, except for a few areas that exhibited a hitherto undescribed mineralization pattern...
  58. ncbi Porcine sheath proteins show periodontal ligament regeneration activity
    Makoto Fukae
    Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    Eur J Oral Sci 114:212-8; discussion 254-6, 381-2. 2006
    ..The 17-kDa sheath protein showed both cytodifferentiation and cementum-regeneration activity, but it is unclear whether its cementum-regeneration activity is derived from its ALP-inducing activity on HPDL cells...
  59. ncbi The 17-kDa sheath protein in enamel proteins induces cementum regeneration in experimental cavities created in a buccal dehiscence model of dogs
    M Kanazashi
    Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    J Periodontal Res 41:193-9. 2006
    ..The purpose of this in vivo study was to identify the cementum regeneration-promoting factor in enamel proteins that is clinically used for periodontal regeneration to induce cementum-promotive and osteopromotive activities...
  60. ncbi Enhanced cementum formation in experimentally induced cementum defects of the root surface with the application of recombinant basic fibroblast growth factor in collagen gel in vivo
    Yasuko Sato
    Department of Oral Functional Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    J Periodontol 75:243-8. 2004
    ....
  61. ncbi Extent and Severity Index based on assessments of radiographic bone loss
    P N Papapanou
    Department of Periodontology, Faculty of Odontology, , Gothenburg, Sweden
    Community Dent Oral Epidemiol 19:313-7. 1991
    ..The potential of the partial indices to predict full-mouth scores could be further enhanced via simple regression models. Such an evaluation should, ideally, be carried out in an independent subject sample...
  62. ncbi Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells
    Hiroyuki Kawaguchi
    Department of Periodontal Medicine, Division of Frontier Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Periodontol 75:1281-7. 2004
    ..The purpose of this study was to examine whether auto-transplantation of MSCs into periodontal osseous defects would be useful for periodontal tissue regeneration...
  63. ncbi Locally applied isosorbide decreases bone resorption in experimental periodontitis in rats
    R F C Leitão
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Ceara, Brazil
    J Periodontol 75:1227-32. 2004
    ..We investigated the effect of local administration of the NO donor isosorbide in an experimental periodontal disease model...
  64. ncbi Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures
    G Thomadakis
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Eur J Oral Sci 107:368-77. 1999
    ..The composite expression of BMPs/OPs during periodontal tissue morphogenesis suggests that optimal therapeutic regeneration may entail the combined use of different BMPs/OPs...
  65. ncbi Development of functional dentin incisors after a partial resection of the odontogenic organ of rat incisors
    José Merzel
    Department of Morphology, Faculdade de Odontologia de Piracicaba, UNICAMP, SP, Brazil
    Arch Oral Biol 51:825-35. 2006
    ..These data and our results, showing the development of a functional dentin incisor, suggest that the root-analogue part of the rodent incisor is an anatomic-physiological entity...
  66. ncbi Experimental intrabony and periodontal defects treated with natural mineral combined with a synthetic cell-binding Peptide in the canine: morphometric evaluations
    Zvi Artzi
    Department of Periodontology, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontol 77:1658-64. 2006
    ..Its efficacy as filler biomaterial in guided tissue regeneration (GTR) and guided bone regeneration (GBR) procedures was evaluated histologically and morphometrically...
  67. ncbi Immunohistochemical study of bone sialoprotein and osteopontin in healthy and diseased root surfaces
    Martin Lao
    Colgate Australian Clinical Dental Research Center, Dental School, University of Adelaide, Adelaide, South Australia, Australia
    J Periodontol 77:1665-73. 2006
    ..The purpose of this investigation was to determine whether the expression and distribution of bone sialoprotein and osteopontin on root surfaces affected by periodontitis are altered compared to healthy, non-diseased root surfaces...
  68. ncbi Synchrotron radiation-based microtomography of alveolar support tissues
    M Dalstra
    Department of Orthodontics, School of Dentistry, University of Aarhus, Denmark
    Orthod Craniofac Res 9:199-205. 2006
    ..To study the alveolar support structures using synchrotron radiation (SR)-based microtomography with particular focus on the alveolar surface...
  69. ncbi Clinical and histologic evaluation of anorganic bovine bone collagen with or without a collagen barrier
    Gary A Hartman
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Int J Periodontics Restorative Dent 24:127-35. 2004
    ..Two sites demonstrated new attachment, and four showed a long junctional epithelium. Periodontal regeneration is possible following a bone-replacement graft of Bio-Oss Collagen...
  70. ncbi Human histology of new attachment after root coverage using subepithelial connective tissue graft
    M Goldstein
    Department of Periodontics, Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem, Israel 91010
    J Clin Periodontol 28:657-62. 2001
    ..New connective tissue attachment was also observed, including periodontal ligament. CONCLUSION: Biological width was comparable pre- and post-surgery, indicating a real gain in attachment of 3.9 mm...
  71. ncbi Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone
    Myron Nevins
    Institute for Advanced Dental Studies, Swampscott, MA, USA
    J Periodontol 74:1282-92. 2003
    ....
  72. ncbi Contact damage to root surfaces of premolars touching miniscrews during orthodontic treatment
    Onur Kadioglu
    Department of Orthodontics, College of Dentistry, University of Oklahoma, Oklahoma City, USA
    Am J Orthod Dentofacial Orthop 134:353-60. 2008
    ..Our aim in this clinical study was to examine premolar root surfaces after intentional contact with miniscrews...
  73. ncbi An association of external and internal enamel pearls
    S Mahajan
    Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences
    Indian J Dent Res 16:17-8. 2005
    ..We discussed the histogenesis of enamel pearls and proposed that internal enamel pearl formation may be a continuation of formation of external enamel pearl...
  74. ncbi Cementum formation around a titanium implant: a case report
    Renzo Guarnieri
    Int J Oral Maxillofac Implants 17:729-32. 2002
    ..Further studies are required to establish whether the neoformation of cementum and collagen fibers on an implant in the presence of root residues occurs only in animal models or whether it may also occur in humans...
  75. ncbi Effect of porous xenographic bone graft with collagen barrier membrane on periodontal regeneration
    Satoru Yamada
    Department of Periodontics, Tokyo Dental College, Chiba, Japan
    Int J Periodontics Restorative Dent 22:389-97. 2002
    ..The use of the collagen barrier membrane in combination with the porous bone graft material may enhance new bone and cementum formation...
  76. ncbi The effect of enamel matrix proteins on periodontal regeneration as determined by histological analyses
    D L Cochran
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1043-55. 2003
    ..The goal of this study was to evaluate periodontal regeneration in intrabony defects of various sizes treated with enamel matrix proteins...
  77. ncbi Differential expression and distribution of syndecan-1 and -2 in periodontal wound healing of the rat
    W Worapamorn
    Faculty of Dentistry, Prince of Songkhla University, Thailand
    J Periodontal Res 37:293-9. 2002
    ..The appearance of syndecan-1 may involve both cell-cell and cell-matrix interactions, while syndecan-2 showed a predilection to associate with cell-matrix interactions during hard tissue formation...
  78. ncbi Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane
    M Camelo
    Brazil Institute for Advanced Dental Studies, Belo Horizonte
    Int J Periodontics Restorative Dent 21:109-19. 2001
    ....
  79. ncbi Multiple teeth showing invasive cervical resorption--an entity with little known histologic features
    M Coyle
    Department of Oral Surgery, Oral Pathology and Oral Medicine, School of Dental Science, Trinity College, Dublin, Ireland
    J Oral Pathol Med 35:55-7. 2006
    ..The case highlights the diagnostic difficulty that may arise in this uncommon lesion, the pathologic features of which may be mistaken for a fibro-osseous lesion or a low-grade sarcoma...
  80. ncbi Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs
    Seong Ho Choi
    Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul
    J Periodontol 73:63-72. 2002
    ..The objective of this study was to evaluate regeneration of alveolar bone and cementum, and associated root resorption and ankylosis following surgical implantation of rhBMP-2/ACS in a canine clinical model...
  81. ncbi Experimental tooth movement through mature and immature bone regenerates after distraction osteogenesis in dogs
    Norimichi Nakamoto
    Tohoku University Graduate School of Dentistry, Sendai, Japan
    Am J Orthod Dentofacial Orthop 121:385-95. 2002
    ..These results indicated that heavy force and early orthodontic tooth movement are not recommended when teeth are moved through regenerated bone created by distraction osteogenesis, to avoid tipping and severe root resorption...
  82. ncbi Periodontal regeneration following use of ABM/P-1 5: a case report
    Raymonda Yukna
    Department of Periodontics, Louisiana State University, School of Dentistry, New Orleans 70119 2799, USA
    Int J Periodontics Restorative Dent 22:146-55. 2002
    ..This case report fulfills the proof of principle that use of ABM/P-15 can result in periodontal regeneration on previously diseased root surfaces in humans...
  83. ncbi Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs
    S Murakami
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Periodontal Res 38:97-103. 2003
    ..The present results indicate that topical application of bFGF can enhance considerable periodontal regeneration in artificially created furcation class II bone defects of beagle dogs...
  84. ncbi Dens invaginatus in a primary molar: report of case
    Ece Koparal Eden
    Department of Pedodontics, Ege University, School of Dentistry, 35100 Bornova Izmir Turkey
    ASDC J Dent Child 69:49-53, 12. 2002
    ..Dentinal tissues were also irregular and had fewer and thinner tubules. This case of dens invaginatus in primary molar is an unusual case of the malformation being the only one in the literature...
  85. ncbi Progressive, generalized, apical idiopathic root resorption and hypercementosis
    Marc Schätzle
    Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Berne, Berne, Switzerland
    J Periodontol 76:2002-11. 2005
    ..The objective of this report was to present a case of a 17-year-old white female with progressive, generalized, apical idiopathic root resorption followed up for 34 months...
  86. ncbi Effect of an oily calcium hydroxide suspension (Osteoinductal) on healing of intrabony periodontal defects. A pilot study in dogs
    Frank Schwarz
    Department of Oral Surgery, Heinrich Heine University, Dusseldorf, Germany
    Clin Oral Investig 10:29-34. 2006
    ..new periodontal ligament, new cementum with inserting collagen fibers, and new bone). Within the limits of the present study, it can be concluded that OCHS may favor periodontal regeneration in acute-type intrabony periodontal defects...
  87. ncbi Immunolocalization of calbindin D28k and vitamin D receptor during root formation of murine molar teeth
    Tomoyuki Onishi
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    Anat Rec A Discov Mol Cell Evol Biol 273:700-4. 2003
    ..The present results indicate that CB expression in newly disrupted cells from Hertwig's epithelial root sheath occurs in a vitamin-D dependent manner, whereas the expression of CB in mature ERM cells may be independent of vitamin D...
  88. ncbi Human histologic and clinical evaluation of recombinant human platelet-derived growth factor and beta-tricalcium phosphate for the treatment of periodontal intraosseous defects
    Heather K Ridgway
    University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Int J Periodontics Restorative Dent 28:171-9. 2008
    ..0-mg/mL sites demonstrated periodontal regeneration. This study provides proof of principle that 0.3 mg/mL and 1.0 mg/mL of rhPDGF-BB and beta-TCP can promote periodontal regeneration in human intraosseous periodontal defects...
  89. ncbi Periodontal repair in dogs: gingival tissue occlusion, a critical requirement for GTR?
    Ulf M E Wikesjö
    Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Clin Periodontol 30:655-64. 2003
    ..The importance of cell or tissue occlusion has yet to be established. The objective of this study was to evaluate the role of tissue occlusion as a critical determinant for GTR outcomes...
  90. ncbi Immunohistochemical evaluation of matrix molecules associated with wound healing following treatment with an enamel matrix protein derivative in humans
    A Sculean
    Department Conservative Dentistry and Periodontology, Johannes Gutenberg University, Augustusplatz 2, 55131 Mainz, Germany
    Clin Oral Investig 7:167-74. 2003
    ....
  91. ncbi Periodontal repair in dogs: evaluation of a bioabsorbable space-providing macroporous membrane with recombinant human bone morphogenetic protein-2
    Ulf M E Wikesjö
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Periodontol 74:635-47. 2003
    ....
  92. ncbi Biological mediators for periodontal and bone regeneration
    Richard J Oringer
    Department of Periodontics, State University of New York at Stony Brook, School of Dental Medicine, Stony Brook, New York, USA
    Compend Contin Educ Dent 23:501-4, 506-10, 512 passim; quiz 518. 2002
    ..The clinical application of these therapies will be to either replace or augment traditional regenerative treatments...
  93. ncbi Effect of soluble receptors to interleukin-1 and tumor necrosis factor alpha on experimentally induced root resorption in rats
    Dongliang Zhang
    Jilin University, Dental School, Department of Orthodontics, Jilin, People s Republic of China
    J Periodontal Res 38:324-32. 2003
    ..In this study, the role of the inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) in the course of mechanically induced root resorption was investigated...
  94. ncbi A histopathologic investigation on the effects of electrical stimulation on periodontal tissue regeneration in experimental bony defects in dogs
    Deniz Kaynak
    Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey
    J Periodontol 76:2194-204. 2005
    ..The present study was designed to examine histopathologically whether the application of an electrical field could demonstrate enhanced alveolar and cementum regeneration and modify tissue factors...
  95. ncbi The side effects of orthodontic mechanics in orthodontic treatments
    Homan H Javaheri
    Shaheed Beheshti Dental Research Center, Iran
    Int J Orthod Milwaukee 19:11-2. 2008
    ..Root resorption is a well-recognized phenomenon following orthodontic treatment. Advances made in this area of research to identify the parameters and genes associated with this process are developing...
  96. ncbi Effect of mechanical loading on periodontal cells
    D Pavlin
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, 78284 7910, USA
    Crit Rev Oral Biol Med 12:414-24. 2001
    ..This finding indicates that differential genetic responses to mechanical loading provide functional markers for distinction of the cementoblast and osteoblast phenotypes...
  97. ncbi Cellular events at the onset of physiological root resorption in rabbit deciduous teeth
    N Sahara
    Department of Oral Histology, Matsumoto Dental University, Shiojiri, Nagano, Japan
    Anat Rec 264:387-96. 2001
    ....
  98. ncbi Immunohistochemical identification of lymphatic vessels in the periodontium of equine cheek teeth
    Carsten Staszyk
    Institute of Anatomy, University of Veterinary Medicine Hannover, Germany
    J Vet Dent 22:227-32. 2005
    ..Lymphatic vessels were detected in all periodontal tissues except for the dental cementum. Lymphatic capillaries were most densely distributed in the gingiva compared to other tissues of the ..
  99. ncbi Models for the study of cementogenesis
    J A D'Errico
    Department of Periodontics Prevention Geriatrics, University of Michigan, Ann Arbor, USA
    Connect Tissue Res 33:9-17. 1995
    ..In contrast, the day 33 control molars demonstrated positive staining for BSP localized to root cementum, with normal formation of dentin...
  100. pmc Growth factors regulate expression of mineral associated genes in cementoblasts
    N E Saygin
    Department of Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor 48109-1078, USA
    J Periodontol 71:1591-600. 2000
    ....
  101. ncbi Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins
    Noriyoshi Mizuno
    Department of Periodontal Medicine, Division of Frontier Medical Science, Programs for Biomedical Research, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Cell Biol Int 29:111-7. 2005
    ..Amelogenin mRNA expression could not be detected in any of the cells. These findings suggest that cultured ERM cells are characterized by expression of the cytokeratin 8, OPG and OPN genes...

Research Grants90

  1. REGULATION OF PERIODONTAL CELLS BY CEMENTUM COMPONENTS
    A Narayanan; Fiscal Year: 2000
    ..abstract_text> ..
  2. REGULATION OF PERIODONTAL CELLS BY CEMENTUM COMPONENTS
    A Narayanan; Fiscal Year: 2001
    ..abstract_text> ..
  3. REGULATION OF PERIODONTAL CELLS BY CEMENTUM COMPONENTS
    A Narayanan; Fiscal Year: 2000
    ..abstract_text> ..
  4. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2001
    ..g., hypophosphatasia, cementomas, and Paget's associated hypercementosis, and for designing effective clinical procedures for regeneration of periodontal tissues, as well as other mineralized tissues. ..
  5. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2000
    ..g., hypophosphatasia, cementomas, and Paget's associated hypercementosis, and for designing effective clinical procedures for regeneration of periodontal tissues, as well as other mineralized tissues. ..
  6. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 2001
    ..g., hypophosphatasia, cementomas, and Paget's associated hypercementosis, and for designing effective clinical procedures for regeneration of periodontal tissues, as well as other mineralized tissues. ..
  7. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMETOGENESIS
    Martha Somerman; Fiscal Year: 1999
    ..g., hypophosphatasia, cementomas, and Paget's associated hypercementosis, and for designing effective clinical procedures for regeneration of periodontal tissues, as well as other mineralized tissues. ..
  8. TISSUE INTERACTIONS IN ROOT DEVELOPMENT
    Huw Thomas; Fiscal Year: 1990
    ....
  9. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2007
    ..abstract_text> ..
  10. Key Modulators of Cementogenesis
    Martha J Somerman; Fiscal Year: 2010
    ....
  11. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2009
    ....
  12. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMENTOGENESIS
    Martha Somerman; Fiscal Year: 2006
    ..This information is necessary for designing regenerative therapies based on sound biological principles. ..
  13. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMENTOGENESIS
    Martha Somerman; Fiscal Year: 2003
    ..This information is necessary for designing regenerative therapies based on sound biological principles. ..
  14. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMENTOGENESIS
    Martha Somerman; Fiscal Year: 2005
    ..This information is necessary for designing regenerative therapies based on sound biological principles. ..
  15. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMENTOGENESIS
    Martha Somerman; Fiscal Year: 2004
    ..This information is necessary for designing regenerative therapies based on sound biological principles. ..
  16. Tools for Tissue Engineering Tooth Structure
    Pamela DenBesten; Fiscal Year: 2002
    ..abstract_text> ..
  17. REGULATION OF PERIODONTAL LIGAMENT REGENERATION
    RONALD CRAIG; Fiscal Year: 1993
    ..derived from the periodontal ligament to regenerate a functional connective tissue attachment consisting of dental cementum, periodontal ligament and alveolar bone...
  18. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2004
    ..In this revision, more experimental details have been provided. ..
  19. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2006
    ..In this revision, more experimental details have been provided. ..
  20. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2005
    ..In this revision, more experimental details have been provided. ..
  21. Signaling activities of amelogenin gene splice products
    Arthur Veis; Fiscal Year: 2003
    ..In this revision, more experimental details have been provided. ..
  22. Primary Genes Promoting Cementoblast Differentiaton
    Sotirios Tetradis; Fiscal Year: 2004
    ..We anticipate that Nur77, egr1, and mkp1 will be key mediators of cementoblast differentiation. These studies will contribute to our understanding of the molecular signals that regulate cementoblast function. ..
  23. Primary Genes Promoting Cementoblast Differentiaton
    Sotirios Tetradis; Fiscal Year: 2005
    ..We anticipate that Nur77, egr1, and mkp1 will be key mediators of cementoblast differentiation. These studies will contribute to our understanding of the molecular signals that regulate cementoblast function. ..
  24. Primary Genes Promoting Cementoblast Differentiaton
    Sotirios Tetradis; Fiscal Year: 2003
    ..We anticipate that Nur77, egr1, and mkp1 will be key mediators of cementoblast differentiation. These studies will contribute to our understanding of the molecular signals that regulate cementoblast function. ..
  25. Primary Genes Promoting Cementoblast Differentiaton
    Sotirios Tetradis; Fiscal Year: 2006
    ..We anticipate that Nur77, egr1, and mkp1 will be key mediators of cementoblast differentiation. These studies will contribute to our understanding of the molecular signals that regulate cementoblast function. ..
  26. Primary Genes Promoting Cementoblast Differentiaton
    Sotirios Tetradis; Fiscal Year: 2007
    ..We anticipate that Nur77, egr1, and mkp1 will be key mediators of cementoblast differentiation. These studies will contribute to our understanding of the molecular signals that regulate cementoblast function. ..
  27. Shaping the craniofacial skeleton in the zebrafish
    April DeLaurier; Fiscal Year: 2008
    ..By investigating the role of genes involved in palate formation, we can begin to test the function of specific genetic pathways in the generation of cleft palate deformities. ..
  28. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2005
    ....
  29. DMP1 Mutations: Defects in Odontogenesis
    Jian Q Feng; Fiscal Year: 2010
    ..In addition, the mouse models which to be generated from these studies can be used to correlate individual gene mutations with the appropriate clinical intervention. ..
  30. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2008
    ..Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration. ..
  31. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
    ..Mouse models mimic the human defects and can be used to correlate individual gene mutations with appropriate clinical intervention. ..
  32. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2009
    ..abstract_text> ..
  33. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
    ..Mouse models mimic the human defects and can be used to correlate individual gene mutations with appropriate clinical intervention. ..
  34. BIOLOGY AND BIOMETRICS OF ENAMEL CRYSTAL GROWTH
    THOMAS DIEKWISCH; Fiscal Year: 2004
    ....
  35. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2004
    ..3) to evaluate LRAP for signal function in vivo and in vitro; and (4) to ascertain additional consequences of absence of amelogenin in maturative ameloblasts, in reparative dentin and during accelerated eruption ..
  36. Enamel Structure Sophistication throuth Amelogenin Evolution
    THOMAS DIEKWISCH; Fiscal Year: 2008
    ..We hope that one day our approach will lead to new ways of repairing human teeth. ..
  37. Tissue Engineering and Regeneration
    Paul Krebsbach; Fiscal Year: 2007
    ..The University of Michigan recognizes the importance of quality training programs and is committed to training oral scientists as independent researchers and life-long learners. ..
  38. STEM CELLS AND PERIODONTAL BIOENGINEERING
    THOMAS DIEKWISCH; Fiscal Year: 2004
    ..3. To test the conditions necessary to differentiate stem cells into periodontal cells in vitro. 4. To ask the question whether stem cells will mimic existing periodontal tissues following tissue implantation. ..
  39. Ninth International Conference on the Chemistry and Biology of Mineralized Tissue
    Paul Krebsbach; Fiscal Year: 2007
    ..The ensuing "cross pollenization" of perspective and expertise is the ideal venue to enhance the process of discovery in this important field. [unreadable] [unreadable] [unreadable]..
  40. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2005
    ..Although rare, individuals with root agenesis have been documented. ..
  41. Osteoblast Lineage Progression from Embryonic Stem Cells
    Paul Krebsbach; Fiscal Year: 2007
    ..These studies will further our understanding of the biology of lineage segregation during normal development and provide essential information for the development of future tissue regeneration strategies. ..
  42. Osteoblast Lineage Progression from Embryonic Stem Cells
    Paul Krebsbach; Fiscal Year: 2005
    ..These studies will further our understanding of the biology of lineage segregation during normal development and provide essential information for the development of future tissue regeneration strategies. ..
  43. BONE MARROW STROMAL CELLS FOR SKELETAL REGENERATION
    Paul Krebsbach; Fiscal Year: 2005
    ..The information gained from this study will provide an essential prerequisite for the development of regenerative approaches that utilize bone marrow stromal cells for gene-and cell-based therapies. ..
  44. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
    ..The use of AAV-TNF: Fc has significant potential as a therapeutic regimen to treat aggressive periodontitis that is governed by an exuberant inflammatory response. ..
  45. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2003
    ..Although rare, individuals with root agenesis have been documented. ..
  46. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2002
    ..Knowledge gained from these studies will produce new insights into the use of gene therapy technologies to restore the periodontium as well as other mineral-associated tissues. ..
  47. BIOLOGY AND BIOMETRICS OF ENAMEL CRYSTAL GROWTH
    THOMAS DIEKWISCH; Fiscal Year: 2001
    ....
  48. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2001
    ..The data generated in this study will also provide information related to the regulation of root formation and possible ways to improve the diagnosis, treatment, and prognosis of tooth loss due to aging or periodontal diseases. ..
  49. CEMENTOGENESIS--ROLE OF HERTWIGS EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2000
    ....
  50. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2001
    ..Knowledge gained from these studies will produce new insights into the use of gene therapy technologies to restore the periodontium as well as other mineral-associated tissues. ..
  51. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 1999
    ....
  52. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 1993
    ....
  53. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2000
    ..This is a unique opportunity to study regulation of a sexually dimorphic gene that has a completely tissue specific pattern of expression. ..
  54. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2003
    ..The data generated in this study will also provide information related to the regulation of root formation and possible ways to improve the diagnosis, treatment, and prognosis of tooth loss due to aging or periodontal diseases. ..
  55. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2003
    ..Knowledge gained from these studies will produce new insights into the use of gene therapy technologies to restore the periodontium as well as other mineral-associated tissues. ..
  56. BIOLOGY AND BIOMETRICS OF ENAMEL CRYSTAL GROWTH
    THOMAS DIEKWISCH; Fiscal Year: 2003
    ....
  57. CP 27 GENE FUNCTION IN TOOTH DEVELOPMENT
    THOMAS DIEKWISCH; Fiscal Year: 2001
    ..Understanding the function of CP27 may provide the basis for the development of novel clinical aids for craniofacial diseases. ..
  58. Materials/Biologic Constructs for Skeletal Regeneration
    Paul Krebsbach; Fiscal Year: 2002
    ..Bone and cartilage formation in our anatomic-specific designed bioengineered materials will facilitate innovative strategies for the reconstruction of human joints. ..
  59. CEMENTOGENESIS--ROLE OF HERTWIGS EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 1999
    ....
  60. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 1992
    ....
  61. MOLECULAR REGULATION OF PERIODONTIUM FORMATION
    Margarita Zeichner David; Fiscal Year: 2009
    ..Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration. ..
  62. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 1999
    ..This is a unique opportunity to study regulation of a sexually dimorphic gene that has a completely tissue specific pattern of expression. ..
  63. Biomimetics for Dentin Regeneration
    R Rutherford; Fiscal Year: 2003
    ..If successful these experiments could lead to efficacy tests in non-human primate models of reparative dentinogenesis (Phase II), human clinical trials and commercialization. ..
  64. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 2001
    ....
  65. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 2001
    ....
  66. MOLECULAR REGULATION OF PERIODONTIUM FORMATION
    Margarita Zeichner David; Fiscal Year: 2010
    ..Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration. ..
  67. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2002
    ..3) to evaluate LRAP for signal function in vivo and in vitro; and (4) to ascertain additional consequences of absence of amelogenin in maturative ameloblasts, in reparative dentin and during accelerated eruption ..
  68. Microarray Facility Project
    R Rutherford; Fiscal Year: 2001
    ....
  69. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 2000
    ....
  70. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2003
    ..3) to evaluate LRAP for signal function in vivo and in vitro; and (4) to ascertain additional consequences of absence of amelogenin in maturative ameloblasts, in reparative dentin and during accelerated eruption ..
  71. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 2002
    ....
  72. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2002
    ..The data generated in this study will also provide information related to the regulation of root formation and possible ways to improve the diagnosis, treatment, and prognosis of tooth loss due to aging or periodontal diseases. ..
  73. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  74. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2004
    ..Although rare, individuals with root agenesis have been documented. ..
  75. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2006
    ..3) to evaluate LRAP for signal function in vivo and in vitro; and (4) to ascertain additional consequences of absence of amelogenin in maturative ameloblasts, in reparative dentin and during accelerated eruption ..
  76. DETERMINANTS OF ROOT RESORPTION DUE TO ORTHODONTIC MOVEMENT
    Margarita Zeichner David; Fiscal Year: 2005
    ....
  77. CEMENTOGENESIS--ROLE OF HERTWIGS EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2001
    ....
  78. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  79. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2005
    ..3) to evaluate LRAP for signal function in vivo and in vitro; and (4) to ascertain additional consequences of absence of amelogenin in maturative ameloblasts, in reparative dentin and during accelerated eruption ..
  80. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2006
    ..Although rare, individuals with root agenesis have been documented. ..