mouth

Summary

Summary: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.

Top Publications

  1. pmc The human oral microbiome
    Floyd E Dewhirst
    Department of Molecular Genetics, The Forsyth Institute, 245 First St, Cambridge, MA 02142, USA
    J Bacteriol 192:5002-17. 2010
  2. pmc Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples
    Nicola Segata
    Department of Molecular Genetics, The Forsyth Institute, Cambridge, MA 02142, USA
    Genome Biol 13:R42. 2012
  3. pmc Defining the normal bacterial flora of the oral cavity
    Jørn A Aas
    Institute of Oral Biology, University of Oslo, Postbox 1052 Blindern, 0316 Oslo, Norway
    J Clin Microbiol 43:5721-32. 2005
  4. pmc Defining the healthy "core microbiome" of oral microbial communities
    Egija Zaura
    Department of Cariology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Free University Amsterdam, The Netherlands
    BMC Microbiol 9:259. 2009
  5. pmc Bacterial diversity in the oral cavity of 10 healthy individuals
    Elisabeth M Bik
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
    ISME J 4:962-74. 2010
  6. pmc The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information
    Tsute Chen
    The Forsyth Institute, Boston, MA 02115, USA
    Database (Oxford) 2010:baq013. 2010
  7. pmc Metagenomic study of the oral microbiota by Illumina high-throughput sequencing
    Vladimir Lazarevic
    Genomic Research Laboratory, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
    J Microbiol Methods 79:266-71. 2009
  8. ncbi Periodontal microbial ecology
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:135-87. 2005
  9. pmc Oral biofilm architecture on natural teeth
    Vincent Zijnge
    Center for Dentistry and Oral Hygiene, University of Groningen, Groningen, The Netherlands
    PLoS ONE 5:e9321. 2010
  10. pmc Characterization of the oral fungal microbiome (mycobiome) in healthy individuals
    Mahmoud A Ghannoum
    Center for Medical Microbiology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS Pathog 6:e1000713. 2010

Detail Information

Publications277 found, 100 shown here

  1. pmc The human oral microbiome
    Floyd E Dewhirst
    Department of Molecular Genetics, The Forsyth Institute, 245 First St, Cambridge, MA 02142, USA
    J Bacteriol 192:5002-17. 2010
    ..The HOMD is the first curated description of a human-associated microbiome and provides tools for use in understanding the role of the microbiome in health and disease...
  2. pmc Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples
    Nicola Segata
    Department of Molecular Genetics, The Forsyth Institute, Cambridge, MA 02142, USA
    Genome Biol 13:R42. 2012
    ..We describe the bacterial community composition of ten digestive tract sites from more than 200 normal adults enrolled in the Human Microbiome Project, and metagenomically determined metabolic potentials of four representative sites...
  3. pmc Defining the normal bacterial flora of the oral cavity
    Jørn A Aas
    Institute of Oral Biology, University of Oslo, Postbox 1052 Blindern, 0316 Oslo, Norway
    J Clin Microbiol 43:5721-32. 2005
    ..It is important to fully define the human microflora of the healthy oral cavity before we can understand the role of bacteria in oral disease...
  4. pmc Defining the healthy "core microbiome" of oral microbial communities
    Egija Zaura
    Department of Cariology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Free University Amsterdam, The Netherlands
    BMC Microbiol 9:259. 2009
    ..The aim of this study therefore was to define the healthy oral microbiome using recent advances in sequencing technology (454 pyrosequencing)...
  5. pmc Bacterial diversity in the oral cavity of 10 healthy individuals
    Elisabeth M Bik
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
    ISME J 4:962-74. 2010
    ..sequences found previously in the large intestines and feces of other healthy individuals suggest that the mouth and intestinal tract harbor distinct sets of bacteria...
  6. pmc The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information
    Tsute Chen
    The Forsyth Institute, Boston, MA 02115, USA
    Database (Oxford) 2010:baq013. 2010
    ..We provide HOMD as a conceptual model for the presentation of microbiome data for other human body sites. Database URL: http://www.homd.org...
  7. pmc Metagenomic study of the oral microbiota by Illumina high-throughput sequencing
    Vladimir Lazarevic
    Genomic Research Laboratory, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
    J Microbiol Methods 79:266-71. 2009
    ..Access to large amounts of data is already leading to a better representation of sample diversity at a reasonable cost...
  8. ncbi Periodontal microbial ecology
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:135-87. 2005
  9. pmc Oral biofilm architecture on natural teeth
    Vincent Zijnge
    Center for Dentistry and Oral Hygiene, University of Groningen, Groningen, The Netherlands
    PLoS ONE 5:e9321. 2010
    ..These in vivo observations on oral biofilms provide a clear vision on biofilm architecture and the spatial distribution of predominant species...
  10. pmc Characterization of the oral fungal microbiome (mycobiome) in healthy individuals
    Mahmoud A Ghannoum
    Center for Medical Microbiology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS Pathog 6:e1000713. 2010
    ..This is the first study that identified the "basal mycobiome" of healthy individuals, and provides the basis for a detailed characterization of the oral mycobiome in health and disease...
  11. pmc Interspecies interactions within oral microbial communities
    Howard K Kuramitsu
    Department of Oral Boiology, School of Dental Medicine, State University of New York, Buffalo, New York, USA
    Microbiol Mol Biol Rev 71:653-70. 2007
    ..This review describes some of these interesting interspecies-interaction scenarios...
  12. pmc Communication among oral bacteria
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    Microbiol Mol Biol Rev 66:486-505, table of contents. 2002
    ..A successful search for genes critical for mixed-species community organization will be accomplished only when it is conducted with mixed-species communities...
  13. ncbi Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing
    Zongxin Ling
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    Microb Ecol 60:677-90. 2010
    ....
  14. ncbi Oral human papillomavirus in healthy individuals: a systematic review of the literature
    Aimee R Kreimer
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Sex Transm Dis 37:386-91. 2010
    ..HPV16 DNA detected in oral specimens has recently been identified as a risk factor for some oropharyngeal cancers. The reported prevalence of oral HPV infection from individual studies is highly variable...
  15. ncbi Mirror neurons responding to the observation of ingestive and communicative mouth actions in the monkey ventral premotor cortex
    Pier Francesco Ferrari
    Dipartimento di Neuroscienze, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
    Eur J Neurosci 17:1703-14. 2003
    ..Here, we describe the mirror responses of F5 neurons that motorically code mouth actions...
  16. ncbi Limited mouth opening after primary therapy of head and neck cancer
    Clemens Weber
    Department of Head and Neck Surgery, University Hospital Rostock Otto Körner, Doberaner Str 137 139, 18057, Rostock, Germany
    Oral Maxillofac Surg 14:169-73. 2010
    ..These problems may be caused by surgery and radiation. Patients complain, for example, of swallowing problems and limited mouth opening (trismus).
  17. pmc Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83
    Karen E Nelson
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    J Bacteriol 185:5591-601. 2003
    ..gingivalis can metabolize a range of amino acids and generate a number of metabolic end products that are toxic to the human host or human gingival tissue and contribute to the development of periodontal disease...
  18. pmc Carbohydrate sensing in the human mouth: effects on exercise performance and brain activity
    E S Chambers
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Physiol 587:1779-94. 2009
    Exercise studies have suggested that the presence of carbohydrate in the human mouth activates regions of the brain that can enhance exercise performance but direct evidence of such a mechanism is limited...
  19. ncbi Impression procedure for patients with severely limited mouth opening
    P S Baker
    Medical College of Georgia Augusta, School of Dentistry, Augusta, GA 30912, USA
    J Prosthet Dent 84:241-4. 2000
    Patients with limited mouth opening are a common occurrence in prosthodontic practice. The majority of these patients can be treated with exercise and stretching movements before impressions are made...
  20. ncbi The oral gram-negative anaerobic microflora in young children: longitudinal changes from edentulous to dentate mouth
    E Kononen
    Institute of Dentistry, Department of Periodontology, University of Helsinki, Finland
    Oral Microbiol Immunol 9:136-41. 1994
    ..were found in all children at the older age, whereas they occurred in edentulous mouth in 76%, 62%, 67% and 19%, respectively...
  21. pmc Characterization of tet(32) genes from the oral metagenome
    Philip Warburton
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
    Antimicrob Agents Chemother 53:273-6. 2009
    ..The regions immediately flanking the gene were found to have similarities to the mobile elements TnB1230 from Butyrivibrio fibrisolvens, ATE-3 from Arcanobacterium pyogenes, and CTn5 from Clostridium difficile...
  22. ncbi Analysis of risk factors of predictive local tumor control in oral cavity cancer
    Chun Ta Liao
    Department of Otorhinolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    Ann Surg Oncol 15:915-22. 2008
    ..In this study, we sought to determine the independent prognosticators for local tumor control, disease-specific survival (DSS), and overall survival (OS) rates in a series of OSCC patients undergoing radical surgery...
  23. pmc Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration
    D J Bradshaw
    Centre for Applied Microbiology and Research, Salisbury SP4 0JG, United Kingdom
    Infect Immun 66:4729-32. 1998
    ..Coaggregation-mediated interactions between F. nucleatum and other species facilitated the survival of obligate anaerobes in aerated environments...
  24. ncbi How the brain represents the reward value of fat in the mouth
    Fabian Grabenhorst
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    Cereb Cortex 20:1082-91. 2010
    ..This discovery of which brain regions track the subjective hedonic experience of fat texture will help to unravel possible differences in the neural responses in obese versus lean people to oral fat, a driver of food intake...
  25. pmc Oral microbial profile discriminates breast-fed from formula-fed infants
    Pernilla L Holgerson
    Department of Odontology, Cariology, Umea University, Umea, Sweden
    J Pediatr Gastroenterol Nutr 56:127-36. 2013
    ..The aims of the present study were to compare the oral microbiota in breast-fed and formula-fed infants, and investigate growth inhibition of streptococci by infant-isolated lactobacilli...
  26. ncbi Health-related quality of life and clinical function after primary surgery for oral cancer
    S N Rogers
    Regional Maxillofacial Unit, University Hospital Aintree, Aintree Trust, Liverpool, UK
    Br J Oral Maxillofac Surg 40:11-8. 2002
    ..The differential in respect of baseline function was present at all three time points in each patient group. This suggests that functional deficits at presentation persist following treatment...
  27. ncbi Variation in bacterial DGGE patterns from human saliva: over time, between individuals and in corresponding dental plaque microcosms
    Indira A Rasiah
    Dental Research Group, Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, P O Box 7343, Wellington 6039, New Zealand
    Arch Oral Biol 50:779-87. 2005
    Eubacterial 16S rDNA fingerprints of human saliva and dental plaque microcosm biofilms grown in the multi-plaque artificial mouth (MAM) were characterised using denaturing gradient gel electrophoresis (DGGE).
  28. ncbi Inorganic chemistry of defensive peroxidases in the human oral cavity
    M T Ashby
    Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
    J Dent Res 87:900-14. 2008
    ..Despite this complexity, intriguing in vitro and in vivo studies are reviewed here that reveal the interplay between peroxidase function and associated inorganic chemistry...
  29. ncbi The immediate effects of atlanto-occipital joint manipulation and suboccipital muscle inhibition technique on active mouth opening and pressure pain sensitivity over latent myofascial trigger points in the masticatory muscles
    Natalia M Oliveira-Campelo
    Escuela de Osteopatía de Madrid, Escola Superior de Tecnología de Saúde, Porto, Portugal
    J Orthop Sports Phys Ther 40:310-7. 2010
    ..A randomized controlled trial...
  30. ncbi Human cortical responses to water in the mouth, and the effects of thirst
    Ivan E T de Araujo
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD Kingdom
    J Neurophysiol 90:1865-76. 2003
    ..Fifth, it was found that a region of the middle part of the insula was also activated by water in the mouth, and further, that this activation only occurred when thirsty...
  31. ncbi Clinical significance of MMP-2 and MMP-9 in patients with oral cancer
    Beena P Patel
    Biochemistry Research Division, Gujarat Cancer and Research Institute, Asarwa, Ahmedabad 380 016, India
    Head Neck 29:564-72. 2007
    ..Therefore, the authors studied plasma and tissue levels of MMP-2 and MMP-9 in oral cancer, the leading malignancy in India...
  32. pmc Fever detection in under 5 children in a tertiary health facility using the infrared tympanic thermometer in the oral mode
    Benedict O Edelu
    Department of Pediatrics, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria
    Ital J Pediatr 37:8. 2011
    ..The oral mercury-in-glass thermometer which has relatively good accuracy cannot be used in children less than 5 years because it requires their cooperation...
  33. ncbi Adaptation to different mouth shapes influences visual perception of ambiguous lip speech
    Benedict C Jones
    School of Psychology, University of Aberdeen, Aberdeen, Scotland
    Psychon Bull Rev 17:522-8. 2010
    We investigated the effects of adaptation to mouth shapes associated with different spoken sounds (sustained /m/ or /u/) on visual perception of lip speech...
  34. ncbi Distribution of selected bacterial species on intraoral surfaces
    Donna L Mager
    Department of Periodontology, The Forsyth Institute, Boston, MA 02115, USA
    J Clin Periodontol 30:644-54. 2003
    ..To examine the proportions of 40 bacterial species in samples from 8 oral soft tissue surfaces and saliva in systemically healthy adult subjects and to compare these microbiotas with those of supra- and subgingival plaque...
  35. ncbi Pristionchus pacificus daf-16 is essential for dauer formation but dispensable for mouth form dimorphism
    Akira Ogawa
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Development 138:1281-4. 2011
    The nematode Pristionchus pacificus shows two forms of phenotypic plasticity: dauer formation and dimorphism of mouth form morphologies...
  36. ncbi Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
    ..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
  37. pmc Analysis of the effects of chlorhexidine on oral biofilm vitality and structure based on viability profiling and an indicator of membrane integrity
    C K Hope
    Microbiology Unit, Division of Infection and Immunity, Eastman Dental Institute for Oral Health Care Sciences, University College London, London, United Kingdom
    Antimicrob Agents Chemother 48:1461-8. 2004
    ....
  38. ncbi The effect of carbohydrate mouth rinse on 1-h cycle time trial performance
    James M Carter
    Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    Med Sci Sports Exerc 36:2107-11. 2004
    To investigate the possible role of carbohydrate (CHO) receptors in the mouth in influencing exercise performance, seven male and two female endurance cyclists (VO(2max) 63.2 +/- 2.7 (mean +/- SE) mL.kg*(-1)...
  39. pmc The epidemiology of oral HPV infection among a multinational sample of healthy men
    Aimee R Kreimer
    National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 20:172-82. 2011
    ..Oral human papillomavirus type-16 (HPV16) infection is a risk factor for oropharyngeal cancer. We examined oral HPV infection among healthy men...
  40. pmc Evaluation of the antimicrobial, antioxidant, and anti-inflammatory activities of hydroxychavicol for its potential use as an oral care agent
    Sandeep Sharma
    Biotechnology Division, Indian Institute of Integrative Medicine, Jammu Tawi, India
    Antimicrob Agents Chemother 53:216-22. 2009
    ....
  41. pmc Development of a multispecies oral bacterial community in a saliva-conditioned flow cell
    Jamie S Foster
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, 30 Convent Dr, MSC 4350, Bethesda, MD 20892, USA
    Appl Environ Microbiol 70:4340-8. 2004
    ..are dynamic associations of more than 500 bacterial species that form biofilms on the soft and hard tissues of the mouth. Understanding the development and spatial organization of oral biofilms has been facilitated by the use of in ..
  42. ncbi Development of spontaneous mouth/tongue movement and related neural activity, and their repression in fetal mice lacking glutamate decarboxylase 67
    Naoko Tsunekawa
    Obata Research Unit, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Eur J Neurosci 21:173-8. 2005
    ..At E14, mouth opening and tongue withdrawal were observed independently at frequency of 14/h each...
  43. ncbi Oral microbial communities: biofilms, interactions, and genetic systems
    P E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 54:413-37. 2000
    ..Identification of contact-inducible genes in streptococci offers an avenue to explore bacterial responses to their environment and leads the way toward understanding communication among inhabitants of a multispecies biofilm...
  44. pmc Rapid succession within the Veillonella population of a developing human oral biofilm in situ
    Robert J Palmer
    Oral Biofilm Communication Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Bethesda, MD 20892, USA
    J Bacteriol 188:4117-24. 2006
    ..Changes in community structure can occur very rapidly in natural biofilm development, and we suggest that this process may influence evolution within this ecosystem...
  45. ncbi Actinomyces naeslundii in initial dental biofilm formation
    I Dige
    Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, Aarhus University, Vennelyst Boulevard 9, 8000 Aarhus C, Denmark
    Microbiology 155:2116-26. 2009
    ..The participation of A. naeslundii in the initial stages of dental biofilm formation may have important ecological consequences...
  46. ncbi The influence of lying positions and postural control on hand-mouth and hand-hand behaviors in 0-4-month-old infants
    Nelci Adriana Cicuto Ferreira Rocha
    Department of Physiotherapy, Neuropediatrics Sector, Federal University of Sao Carlos UFSCar, Rua Miguel Mazzei 130, Residencial Samambaia, CEP 13565 570, Sao Carlos, SP, Brazil
    Infant Behav Dev 31:107-14. 2008
    The purpose of this study was to verify how and when body position and postural control affect hand-mouth and hand-hand behaviors in infants during their first 4 months of life...
  47. ncbi Tongue movement and intra-oral vacuum in breastfeeding infants
    Donna T Geddes
    The University of Western Australia, Biochemistry and Molecular Biology, School of Biomedical, Biomolecular and Chemical Sciences, Faculty of Life and Physical Sciences, Australia
    Early Hum Dev 84:471-7. 2008
    ..The aim of this study was to use ultrasound to observe movements of the tongue during breastfeeding and relate these movements to both milk flow and simultaneous measurements of intra-oral vacuum...
  48. ncbi Determining the antibiotic resistance potential of the indigenous oral microbiota of humans using a metagenomic approach
    Martha L Diaz-Torres
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, UK
    FEMS Microbiol Lett 258:257-62. 2006
    ..However, only the first three of these were detected in all three groups of individuals investigated...
  49. pmc The smaller your mouth, the longer your snout: predicting the snout length of Syngnathus acus, Centriscus scutatus and other pipette feeders
    Marc H E de Lussanet
    Psychologisches Institut II, Munster University, Fliednerstrasse 21, Munster, Germany
    J R Soc Interface 4:561-73. 2007
    ..In spite of the small cross-section, the development of a long snout can be an evolutionary advantage because this reduces the time to approach the prey...
  50. ncbi The effect of tobacco blend additives on the retention of nicotine and solanesol in the human respiratory tract and on subsequent plasma nicotine concentrations during cigarette smoking
    Alan K Armitage
    Sycamore Lodge, Abbey Road, Knaresborough, North Yorkshire, HG5 8X, United Kingdom
    Chem Res Toxicol 17:537-44. 2004
    ..of nicotine and solanesol and on the uptake of nicotine into venous blood was investigated in 10 smokers under mouth-hold and 75 and 500 mL inhalation conditions...
  51. ncbi Mouth opening: a new angle
    Ian Calder
    Department of Anethesia and Intensive Care, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Anesthesiology 99:799-801. 2003
    The authors hypothesized that craniocervical extension occurs during normal mouth opening.
  52. pmc A consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis
    Daniel H Fine
    Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    J Clin Microbiol 51:2850-61. 2013
    ..actinomycetemcomitans, S. parasanguinis, and F. alocis together indicates sites of future BL in LAP. A synergistic interaction of this consortium in LAP causation is possible and is the subject of ongoing research. ..
  53. ncbi Hand-mouth transfer and potential for exposure to E. coli and F+ coliphage in beach sand, Chicago, Illinois
    Richard L Whitman
    United States Geological Survey, Great Lakes Science Center, Lake Michigan Ecological Research Station, 1100 N Mineral Springs Road, Porter, IN 46304, USA
    J Water Health 7:623-9. 2009
    ....
  54. ncbi Retrieval of biofilms from the oral cavity
    R J Palmer
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Methods Enzymol 337:393-403. 2001
    ....
  55. pmc Synchrotron-aided reconstruction of the conodont feeding apparatus and implications for the mouth of the first vertebrates
    Nicolas Goudemand
    Palaeontological Institute and Museum, University of Zurich, CH 8006 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:8720-4. 2011
    ..This would lend strong support to their interpretation as vertebrates and demonstrates that the presence of such cartilage is a plesiomorphic condition of crown vertebrates...
  56. pmc The pathogenic persona of community-associated oral streptococci
    Sarah E Whitmore
    Center for Oral Health and Systemic Disease, School of Dentistry, University of Louisville, Louisville, KY 40202, USA
    Mol Microbiol 81:305-14. 2011
    ..We propose that MGS should be considered accessory pathogens, organisms whose pathogenic potential only becomes evident in the context of a heterotypic microbial community...
  57. ncbi Noggin null allele mice exhibit a microform of holoprosencephaly
    Eva Lana-Elola
    Department of Craniofacial Development, King s College, London, UK
    Hum Mol Genet 20:4005-15. 2011
    ....
  58. pmc Mode of birth delivery affects oral microbiota in infants
    P Lif Holgerson
    Department of Odontology, Cariology Section, Umea University, 901 87 Umea, Sweden
    J Dent Res 90:1183-8. 2011
    ..In conclusion, our study indicated differences in the oral microbiota in infants due to mode of delivery, with vaginally delivered infants having a higher number of taxa detected by the HOMIM microarray...
  59. pmc Induction of canonical Wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella vectensis
    Michael Trevino
    Biology Department, Wabash College, Crawfordsville, IN 47933, USA
    Dev Dyn 240:2673-9. 2011
    ..These data also contribute to a growing body of literature indicating a conserved role for patterning mechanisms across various developmental modes of metazoans...
  60. ncbi The Italian version of the Mouth Handicap in Systemic Sclerosis scale (MHISS) is valid, reliable and useful in assessing oral health-related quality of life (OHRQoL) in systemic sclerosis (SSc) patients
    S Maddali Bongi
    Department of Biomedicine, Division of Rheumatology, Denothe Centre, Careggi Hospital AOUC, University of Florence, Villa Monna Tessa, Viale Pieraccini 18, 50139 Firenze, Italy
    Rheumatol Int 32:2785-90. 2012
    In systemic sclerosis (SSc), mouth and face involvement leads to problems in oral health-related quality of life (OHRQoL)...
  61. ncbi Real-time magnetic resonance imaging of normal swallowing
    Shuo Zhang
    Biomedizinische NMR Forschungs GmbH am Max Planck Institut für biophysikalische Chemie, Gottingen, Germany
    J Magn Reson Imaging 35:1372-9. 2012
    ..To evaluate the use of a novel real-time magnetic resonance imaging (MRI) technique for the assessment of normal swallowing dynamics...
  62. ncbi Environmental and centrifugal factors influencing the visco-elastic properties of oral biofilms in vitro
    Brandon W Peterson
    Department of Biomedical Engineering, W J Kolff Institute, University Medical Center Groningen and University of Groningen, 9713 AV Groningen, The Netherlands
    Biofouling 28:913-20. 2012
    ..In summary, the effects of centrifugal compaction of initially adhering, centrifuged bacteria extend to the visco-elastic properties of biofilms, indicating that the initial bacterial layer influences the structure of the entire biofilm...
  63. ncbi Estimating smokers' mouth-level exposure to select mainstream smoke constituents from discarded cigarette filter butts
    Gregory M Polzin
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, N E, Mailstop F 55, Atlanta, GA 30341, USA
    Nicotine Tob Res 11:868-74. 2009
    ....
  64. ncbi Is the coupled control of hand and mouth postures precursor of reciprocal relations between gestures and words?
    Maurizio Gentilucci
    Department of Neuroscience, University of Parma, Parma, Italy
    Behav Brain Res 233:130-40. 2012
    We tested whether a system coupling hand postures related to gestures to the control of internal mouth articulators during production of vowels exists and it can be precursor of a system relating hand/arm gestures to words...
  65. pmc Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival
    Li Ang Lee
    Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    PLoS ONE 7:e40767. 2012
    ..Human papillomavirus (HPV) is an oncogenic virus causing oropharyngeal cancers and resulting in a favorable outcome after the treatment. The role of HPV in oral cavity squamous cell carcinoma (OSCC) remains ambiguous...
  66. pmc Do postures of distal effectors affect the control of actions of other distal effectors? Evidence for a system of interactions between hand and mouth
    Maurizio Gentilucci
    Department of Neuroscience, University of Parma, Parma, Italy
    PLoS ONE 6:e19793. 2011
    ..In experiments 1 and 2, participants reached different objects with their head and grasped them with their mouth, after assuming different hand postures...
  67. pmc Complete genome sequence of the commensal Streptococcus salivarius strain JIM8777
    Eric Guedon
    Institut Micalis Microbiologie de l Alimentation au service de la Santé, INRA UMR1319 et AgroParisTech, Domaine de Vilvert, F 78350 Jouy en Josas Cedex, France
    J Bacteriol 193:5024-5. 2011
    ..Here, we report the complete 2.2-Mb genome sequence and annotation of strain JIM8777, which was recently isolated from the oral cavity of a healthy, dentate infant...
  68. pmc Preventing root caries development under oral biofilm challenge in an artificial mouth
    May Lei Mei
    Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Hong Kong SAR, China
    Med Oral Patol Oral Cir Bucal 18:e557-63. 2013
    To study the preventive effects of chlorhexidine against root caries under oral biofilm in an artificial mouth.
  69. pmc Genome sequence of the bacteriocin-producing oral probiotic Streptococcus salivarius strain M18
    Nicholas C K Heng
    Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, P O Box 647, Dunedin 9054, New Zealand
    J Bacteriol 193:6402-3. 2011
    ..Here, we present the draft genome sequence of the bacteriocin-producing oral probiotic S. salivarius strain M18...
  70. ncbi Possible association between amniotic fluid micro-organism infection and microflora in the mouth
    Caroline Bearfield
    Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, UK
    BJOG 109:527-33. 2002
    ..To determine whether oral bacteria are found in the amniotic cavity...
  71. pmc Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts
    Colin D Bingle
    Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, S10 2JF, UK
    Histochem Cell Biol 133:505-15. 2010
    ....
  72. ncbi Cephalic neural crest cells and the evolution of craniofacial structures in vertebrates: morphological and embryological significance of the premandibular-mandibular boundary
    Shigeru Kuratani
    Laboratory for Evolutionary Morphology, Center for Developmental Biology CDB, RIKEN, 2 2 3 Minatojima minami, Kobe, Hyogo 650 0047, Japan
    Zoology (Jena) 108:13-25. 2005
    ..Therefore, embryological terminology should reflect these hierarchical patterns in developmental stages and phylogeny...
  73. ncbi Effect of oral bacteria on growth and survival of Candida albicans biofilms
    Zaw M Thein
    Faculty of Dentistry, The University of Hong Kong, Oral Biosciences, 5 F, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong
    Arch Oral Biol 51:672-80. 2006
    ..Taken together, our data indicate that, quantitative and qualitative nature of the bacteria modulate C. albicans biofilm formation in mixed species environments such as the oral cavity...
  74. ncbi Molecular and cellular mechanisms that lead to Candida biofilm formation
    J M Ten Cate
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Free University Amsterdam, Louwesweg 1, 1066 EA Amsterdam, The Netherlands
    J Dent Res 88:105-15. 2009
    ....
  75. ncbi Prevalence of facial pain in migraine: a population-based study
    M S Yoon
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cephalalgia 30:92-6. 2010
    ..23, P < 0.001). In one case isolated facial pain without headache was the leading symptom of migraine. Our results demonstrate that facial pain is not unusual in migraine, whereas isolated facial migraine is extremely rare...
  76. pmc Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture
    Wilfried Engelke
    Dentistry Centre, Department of Maxillofacial Surgery, University of Gottingen, Gottingen, Germany
    Clin Oral Investig 15:165-76. 2011
    ..Twenty subjects with normal occlusion were evaluated during the open-mouth condition (OC), gently closed lips (semi-open compartment condition, SC), with closed compartments after the ..
  77. pmc Non-Hodgkin lymphoma affecting the tongue: unusual intra-oral location
    Francesco Inchingolo
    Department of Dental Sciences and Surgery, General Hospital, Bari, Italy
    Head Neck Oncol 3:1. 2011
    ..The intraoral location is not frequent (3 - 5 percent of cases) and the initial manifestations of the disease rarely take place here...
  78. ncbi Update on bacteraemia related to dental procedures
    Ingar Olsen
    Institute of Oral Biology, Faculty of Dentistry, University of Oslo, PB 1052 Blindern, 0316 Oslo, Norway
    Transfus Apher Sci 39:173-8. 2008
    ..It may be that patients never seeing a dentist are more unfitted as blood donors than those recently having seen one...
  79. ncbi Are dental diseases examples of ecological catastrophes?
    P D Marsh
    Research Division, Centre for Applied Microbiology and Research, Salisbury SP4 0JG, UK
    Microbiology 149:279-94. 2003
    ..Thus, a more holistic approach can be taken in disease control and management strategies...
  80. ncbi Use of the Arndt wire-guided endobronchial blocker via nasal for one-lung ventilation in patient with anticipated restricted mouth opening for esophagectomy
    Chee Yueh Angie Ho
    Department of Anesthesia, Chang Gung Memorial Hospital, 5, Fu Shin Street, Kweishan, Taoyuan 333, Taiwan, ROC
    Eur J Cardiothorac Surg 28:174-5. 2005
    Functional separation of the lungs may be accomplished by several methods. Patient with restricted mouth opening has limited options for one-lung ventilation...
  81. ncbi Happy mouth and sad eyes: scanning emotional facial expressions
    Hedwig Eisenbarth
    Department of Forensic Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Emotion 11:860-5. 2011
    ..Locations of fixations and their durations were recorded, and a dominance ratio (i.e., eyes and mouth relative to the rest of the face) was calculated...
  82. ncbi Human oral cavity as a model for the study of genome-genome interactions
    Jamie S Foster
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, 30 Convent Drive MSC 4350, Bethesda, Maryland 20892 4350, USA
    Biol Bull 204:200-4. 2003
    ..Together, these approaches provide insight into the development of oral biofilms and expand our understanding of genome-genome interactions...
  83. pmc Relationship between oral malodor and the global composition of indigenous bacterial populations in saliva
    Toru Takeshita
    Section of Preventive Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Higashi ku, Fukuoka, Japan
    Appl Environ Microbiol 76:2806-14. 2010
    ..Two parameters for measuring oral malodor intensity (the concentration of volatile sulfur compounds in mouth air and the organoleptic score) were noticeably lower in cluster I than in the other clusters...
  84. ncbi Oral pain perception and taste in burning mouth syndrome
    T Just
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, Germany
    J Oral Pathol Med 39:22-7. 2010
    Aim of this study was to investigate the effect of idiopathic burning mouth syndrome (BMS) on both, the pain perception within trigeminal lingual nerve distribution and gustatory sensitivity using capsaicin threshold test, and regional ..
  85. ncbi Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France--The EDiTH VI study
    Jean Lacau St Guily
    Service d Oto Rhino Laryngologie et Chirurgie Cervico Faciale, Hopital Tenon, Université de Paris 6 et Faculté de Médecine Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, 4 rue de la Chine, 75970 Paris Cedex 20, France
    J Clin Virol 51:100-4. 2011
    ..Recent studies suggest an association between human papillomavirus (HPV) infection and several head and neck cancers, especially oropharyngeal and oral cavity invasive carcinomas...
  86. ncbi Myoanatomy of the marine tardigrade Halobiotus crispae (Eutardigrada: Hypsibiidae)
    Kenneth Agerlin Halberg
    Department of Biology, The August Krogh Building, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Morphol 270:996-1013. 2009
    ..This study establishes a morphological framework for the use of muscular architecture in elucidating tardigrade phylogeny...
  87. ncbi Natural orifice surgery on thyroid gland: totally transoral video-assisted thyroidectomy (TOVAT): report of first experimental results of a new surgical method
    T Benhidjeb
    Department of General, Visceral, Vascular and Thoracic Surgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Surg Endosc 23:1119-20. 2009
    ..Furthermore, the mouth mucosa can be sutured without difficulties and repairs itself without leaving any visible scars...
  88. ncbi Genetic support for random mating between left and right-mouth morphs in the dimorphic scale-eating cichlid fish Perissodus microlepis from Lake Tanganyika
    H J Lee
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Universitatstrasse 10, 78457 Konstanz, Germany
    J Fish Biol 76:1940-57. 2010
    Population genetic analyses were conducted to investigate whether random mating occurs between left and right-mouth morphs of the dimorphic scale-eating cichlid fish Perissodus microlepis from two geographical sites in southern Lake ..
  89. pmc Differential response of Streptococcus mutans towards friend and foe in mixed-species cultures
    Jinman Liu
    College of Dentistry, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Microbiology 157:2433-44. 2011
    ..gordonii are carbohydrate utilization and H₂O₂ resistance. The presence of V. parvula in the tri-species culture mitigates these two major factors and allows S. mutans to proliferate, despite the presence of S. gordonii...
  90. ncbi Preservation of mouth region processing in two cases of prosopagnosia
    Cindy M Bukach
    Department of Psychology, University of Richmond, Richmond, Virginia, USA
    J Neuropsychol 2:227-44. 2008
    ..differences in the eye region, but a preserved ability to detect featural and configural differences in the mouth region. This pattern of impairment and sparing was demonstrated in tests of direct perception and immediate memory...
  91. pmc The oral microbiota: living with a permanent guest
    Maria Avila
    University of California, Merced, 95344, USA
    DNA Cell Biol 28:405-11. 2009
    ..How the microbiome of the oral cavity contributes to health and disease is attracting the interest of a growing number of cell biologists, microbiologists, and immunologists...
  92. ncbi Molecular investigation of macrolide and Tetracycline resistances in oral bacteria isolated from Tunisian children
    Bochra Kouidhi
    Laboratoire d Analyses, Traitement et Valorisation des Polluants de l Environnement et des Produits, Faculté de Pharmacie de Monastir, Biologie clinique, Rue Avicenne, 5000 Monastir, Tunisie
    Arch Oral Biol 56:127-35. 2011
    ..This study aims to investigate the antibiotic susceptibility of strains isolated from the oral cavity of Tunisian children...
  93. pmc Cloning and characterization of an alpha-enolase of the oral pathogen Streptococcus mutans that binds human plasminogen
    Micheala N Jones
    Department of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 364:924-9. 2007
    ..Further studies of this interaction may be critical to understand the pathogenesis of endocarditis caused by S. mutans...
  94. ncbi Immediate effects of atlanto-occipital joint manipulation on active mouth opening and pressure pain sensitivity in women with mechanical neck pain
    Pilar Mansilla-Ferragut
    Professor, Escuela de Osteopatía de Madrid, Spain
    J Manipulative Physiol Ther 32:101-6. 2009
    ..of a spinal thrust manipulation directed to the upper cervical segments (atlanto-occipital joint) on active mouth opening and pressure pain sensitivity in a trigeminal nerve innervated region (sphenoid bone) in women with ..
  95. ncbi Neuronal representations of stimuli in the mouth: the primate insular taste cortex, orbitofrontal cortex and amygdala
    Mikiko Kadohisa
    University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
    Chem Senses 30:401-19. 2005
    ..Information about the taste, texture of what is in the mouth (viscosity, fat texture and grittiness, which reflect somatosensory inputs), temperature and capsaicin is ..
  96. ncbi Grasp with hand and mouth: a kinematic study on healthy subjects
    M Gentilucci
    Istituto di Fisiologia Umana, I 43100 Parma, Italy
    J Neurophysiol 86:1685-99. 2001
    Neurons involved in grasp preparation with hand and mouth were previously recorded in the premotor cortex of monkey...
  97. ncbi Artificial mouth model systems and their contribution to caries research: a review
    Gaoyan Tang
    Oral Biosciences, The Prince Philip Dental Hospital, 34 Hospital Road, The University of Hong Kong, Hong Kong, People s Republic of China
    J Dent 31:161-71. 2003
    ..These developments and in particular the in vitro 'artificial mouth' systems have progressed from simple and basic apparatus devised by Magitot and Miller at the end of 19th century ..
  98. ncbi Cervical and oral human papillomavirus types in HIV-1 positive and negative women with cervical disease in South Africa
    Dianne J Marais
    Division of Medical Virology, Department of Clinical Laboratory Science, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 80:953-9. 2008
    ..HIV+ women had more multiple HPV infections and those with severe cervical disease a similar prevalence of HIV-16 but a lower HPV-18 prevalence than HIV- women...
  99. pmc Oral Candida infection and colonization in solid organ transplant recipients
    A Dongari-Bagtzoglou
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1710, USA
    Oral Microbiol Immunol 24:249-54. 2009
    ..The objectives of this study were to determine the prevalence of oropharyngeal candidiasis, the oral carrier status, Candida titers and species in this population...
  100. ncbi Carbohydrate in the mouth immediately facilitates motor output
    Nicholas Gant
    Exercise Metabolism Laboratory, University of Auckland, Auckland, New Zealand
    Brain Res 1350:151-8. 2010
    The presence of carbohydrate in the mouth can immediately improve physical performance. How this occurs is not well understood...
  101. pmc Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth
    Yann Marcy
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:11889-94. 2007
    ..This approach enables single-cell genetic analysis of any uncultivated minority member of a microbial community...

Research Grants81

  1. IL-4 Signaling Pathway Regulation of Sjogren's Syndrome
    AMMON PECK; Fiscal Year: 2004
    ..specific anti-nuclear autoantibodies, loss of stimulated fluid secretion, and complaints of dry eyes and/or dry mouth. Over the past several years, the NOD mouse has been shown to exhibit numerous disease manifestations that ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..to place in the eye four times a day for 1 week following the injection, and a dose of folic acid to be taken by mouth the day after the injection...
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..to place in the eye four times a day for 1 week following the injection, and a dose of folic acid to be taken by mouth the day after the injection...
  4. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Profound salivary gland hypofunction and xerostomia (dry mouth) are increasingly common occurrences and are often the consequences of: 1) Sjogren's Syndrome, an autoimmune disease that targets ..
  5. Developing Physics-Based Virtual Simulation Technology for Natural Orifice Transl
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..the viscera (stomach, colon or vagina) using a flexible endoscope inserted through natural orifices such as the mouth, anus or vagina;without making any incisions on the surface of the body...
  6. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    ..commonly used clinical measures can be used to forecast the long-term prognosis of any tooth in a patient's mouth at any given time...
  7. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..causes significant side effects in the surrounding oral mucosa (blistering/mucositis) and salivary glands (dry mouth/xerostomia)...
  8. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    ..The ideal therapeutic agent to treat IBD would be administered by mouth. However, drug delivery to the inflamed intestine remains a challenge for two main reasons: 1) lack of highly ..
  9. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..These include cleft palate, a failure of the roof of the mouth to join at birth which occurs in approximately 1 in 1000 live births...
  10. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..These include cleft palate, a failure of the roof of the mouth to join at birth which occurs in approximately 1 in 1000 live births...
  11. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
    ..It is also tempting to speculate that the unique physical characteristics of the mouth and alveolar bone can provide a link between osteonecrosis of the jaw and cherubism...
  12. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..in cancer patients often damages the mucosal lining of the gastrointestinal (GI) tract - especially the mouth and throat, a complication called mucositis...
  13. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2012
    ..parasites cause fatal disease of the internal organs as well as non-healing and disfiguring diseases of the skin, mouth, and nose...
  14. Metagenomic profiling of oral polymicrobial flora in head and neck cancers
    Charis Eng; Fiscal Year: 2011
    ..then our current proposal promises a new understanding of the role of specific subpopulations of bacteria in the mouth leading to inflammation which shuts off cancer-suppressing genes, thus leading to HNSCC...
  15. Translational Research and Evolving Alcoholic hepatitis Treatment (TREAT-IU)
    David W Crabb; Fiscal Year: 2013
    ..adults with AH of moderate severity will be randomized to receive either obeticholic acid (10 mg once daily by mouth) or placebo for 4 weeks...
  16. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
    ..not been greatly satisfactory, and is further confounded by serious unwanted side effects such as insomnia, dry mouth, seizure, nausea, headache, psychotropic and gastrointestinal upset...
  17. Sleep Disordered Breathing and Growth in Children: A Longitudinal Cohort Study
    Karen Bonuck; Fiscal Year: 2009
    ..growth failures (GF) in children, and sleep disordered breathing (SDB) characterized by snoring, apnea, and mouth-breathing. Adenotonsillar hypertrophy is the primary factor leading to SDB in children...
  18. Reducing Care-Resistant Behaviors During Oral Hygiene in Persons with Dementia
    Rita A Jablonski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nursing home (NH) residents with dementia are often dependent on others for mouth care, yet will react with care-resistant behavior (CRB) when receiving assistance...
  19. Tousled kinase contributes to survival of salivary acinar cells against radiation
    Gulshan Sunavala-Dossabhoy; Fiscal Year: 2013
    ..glands causes a dramatic drop in saliva production, leading to a condition referred to as xerostomia or dry mouth. Reduced saliva in the mouth causes intense burning pain and makes basic functions such as tasting, chewing, ..
  20. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The genomes of a number of viruses, including poliovirus, hepatitis C virus and foot-and-mouth disease virus contain structured RNA elements known as `internal ribosomal entry sites'that promote viral ..
  21. Oral Mucins as a Diagnostic Indicator and Therapeutic Treatment for Xerostomia
    DAVID JOHN CULP; Fiscal Year: 2011
    ..of oral dryness (xerostomia) by patients suffering from oral diseases, such as Sjvgren's syndrome and Burning Mouth Syndrome, is associated with an alteration in expression of one or more mucins by the oral epithelium and/or ..
  22. Green tea effects on gene expression in tobacco users
    Joel L Schwartz; Fiscal Year: 2013
    ..Our hypothesis is that cells obtained from the mouth using noninvasive methods can be used to determine what 5 cups per day GT consumption does to epithelial cell ..
  23. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..The new knowledge may also be applicable to other immuno-pathological conditions of the mouth such as oral cancer and gingivitis...
  24. Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and Calcineurin
    William A Sather; Fiscal Year: 2010
    ..2 enhances channel activity, resulting in increased Ca2+ influx. The elevated Ca2+ near the intracellular mouth of the channel activates the CaN phosphatase, which acts to reverse channel phosphorylation and consequently down-..
  25. The Vaginal Microbiome: Disease, Genetics and the Environment
    GREGORY ALLEN BUCK; Fiscal Year: 2012
    ..second subaim will address the question of whether there is a relationship between the microbiomes of the vagina, mouth and GI tract utilizing samples collected from the DZ and MZ twins. Specific Aim 2...
  26. Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
    Heather M Stapleton; Fiscal Year: 2012
    ..to measure children's (ages 1-4) exposure to PBDEs from indoor dust, determine ingestion rates from hand to mouth contact, and measure serum levels of PBDEs in these children;2) to determine the products of hepatic metabolism of ..
  27. Oral Immunobiology of MCMV-infected Mouse Salivary Glands
    Steven D London; Fiscal Year: 2010
    ..in diminished salivary output and/or altered salivary composition results in the subjective sensation of dry mouth (xerostomia)...
  28. Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects
    Christina L Nance; Fiscal Year: 2011
    ..of the study, the total number of capsules that each participant is to take will be the same (five capsules by mouth twice daily)...
  29. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..The goal is the development of a medicine with proven safety that can be easily taken by mouth both during a flare-up of the disease as well as a maintenance treatment.
  30. Physiology and regulation of T2R bitter taste receptors in enteroendocrine cells
    Timothy F Osborne; Fiscal Year: 2013
    ..may limit absorption of bitter and potentially toxic molecules that are ingested despite the taste aversion in the mouth. We also showed that intestinal expression and activity of the T2Rs is regulated by the sterol regulatory element ..
  31. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2012
    ..their arm and hand just by thinking about doing so while also allowing them to retain normal use of their face and mouth. Two main types of implanted brain recording technologies are being developed and commercialized for chronic human ..
  32. A Novel Therapy for Radiation-Induced Xerostomia Using Human Salivary Stem Cells
    QUYNH THU XUAN LE; Fiscal Year: 2012
    ..In >70% of these patients, RT results in chronic xerostomia (dry mouth), which can adversely impact their quality of life and lead to severe subsequent complications, such as mandibular ..
  33. Combinatorial Imaging of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The human mouth is colonized by a microbial community of enormous complexity that plays a key role in human health and disease...
  34. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ..La contributes to tumor growth and bone invasion in vivo, by creating a La-overexpressing orthotopic floor-of- mouth mouse model...
  35. Telomere Attrition Rate and Periodontitis: a nested case control study in the ARI
    ANNE ELIZABETH SANDERS; Fiscal Year: 2013
    ..At Visit 4, when the cohort was aged 54-73 years, 6,691 ARIC Study participants received a full mouth periodontal examination...
  36. Molecular Imaging of Metastatic Potential in SCCHN by Targeting VLA-4 and CXCR4
    Carolyn J Anderson; Fiscal Year: 2013
    ..either highly metastatic (OSC-19) or non-metastatic (UM22B) SCCHN tumor cells are injected into the floor of the mouth. PET and optical Imaging data will be quantified and correlated with rates and extent of metastasis...
  37. Functions of MRP2 and MRP3 in Drug Disposition
    James M Gallo; Fiscal Year: 2011
    ..These improvements could potentially allow the drugs to be given by mouth instead of intravenously, and also reduce the side effects that are associated with the way the body disposes of ..
  38. Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth Cancers
    JOHN MARTIN BROWN; Fiscal Year: 2012
    ..Targeting both the local tumor and the bone marrow derived cells is a novel paradigm and could lead to a major increase in the curability of GBM and head and neck tumors by radiotherapy. ..
  39. Daily Mouth Care to Prevent Pneumonia in Nursing Homes: A Systems-Level Approach
    Sheryl Zimmerman; Fiscal Year: 2013
    ..In aspiration, contents from the mouth, throat, or stomach that are colonized with pathogenic bacteria are inhaled into the lungs...
  40. Addressing Oral Health Disparities in Individuals with Mental Health Problems
    Lisa J Heaton; Fiscal Year: 2013
    ..Directly, psychotropic medications can cause dry mouth symptoms harmful to oral health...
  41. Role of the Bradykinin Pathway in Craniofacial Development
    LAURA ANNE JACOX; Fiscal Year: 2013
    ..Specific focus is on the jaws, derived from the neural crest, and on the mouth. The mouth develops from the "extreme anterior domain" (EAD), where the ectoderm and endoderm directly juxtapose...
  42. Validation of a Genomic Biomarker of Response to Environmental Tobacco Smoke
    AVRUM E SPIRA; Fiscal Year: 2012
    ..genomic biomarkers to assess the biologic response to SHS by profiling cells that can be collected from the mouth or nose using minimally invasive procedures...
  43. In Vivo Measures of Vocal Function Response to Environmental Conditions
    MARY JOYCE SANDAGE; Fiscal Year: 2012
    ..pressure, and humidity influence phonatory onset, regional laryngeal temperature, and perception of vocal ease for mouth versus nose inhalation using a within-subject repeated measures design...
  44. Leveraging Opportunities to Improve Oral Health in Older Adults
    MARY EVELYN NORTHRIDGE; Fiscal Year: 2011
    ..accumulation of advantageous and disadvantageous experiences at multiple scales, from the micro-scale of the mouth to the societal scale that involves US federal policy, including lack of routine dental care coverage under ..
  45. Role of miRNA-375 in Invasive Phenotype of Head and Neck Squamous Cell Carcinoma
    Lizandra Jimenez; Fiscal Year: 2013
    ..In addition HNSCC floor-of-mouth xenografts generated from UMSCC47 transductant cell lines will be used to evaluate the consequence of miR-375 ..
  46. Immune-pathophysiology of lymphocytic foci in Sjogren's syndrome
    Cuong Q Nguyen; Fiscal Year: 2010
    ..a result of a chronic immune attack primarily against the salivary and lacrimal glands leading to xerostomia (dry mouth) and xerophthalmia (dry eyes). While a number of other tissues may become involved (e.g...
  47. Ultrasound-Assisted AQP1 Gene Therapy for Functional Restoration of Salivary Glan
    Michael J Passineau; Fiscal Year: 2013
    ..HEALTH RELEVANCE: This application will implement a gene therapy strategy for radiation-induced xerostomia, or dry mouth, a nearly inevitable consequence of head and neck radiation affecting thousands of cancer survivors...
  48. Targeting the DNA Damage Response for the Treatment of Herpes Simplex Labialis
    WILLIAM DONEGAN; Fiscal Year: 2013
    ..HSL refers to HSV-1 infection of the lip and mouth, and is the most common of these maladies...
  49. Microbiomes in Human Pancreatic Cancer
    Dominique S Michaud; Fiscal Year: 2013
    ..of state-of-the-art molecular techniques;(2) examine possible routes of bacteria dissemination from the mouth to the pancreas...
  50. A Topical Host Defense Peptide Mimetic for Oral Mucositis
    Richard W Scott; Fiscal Year: 2012
    ..It impacts virtually all patients receiving concomitant chemoradiation therapy for tumors of the mouth and oropharynx...
  51. Pre-clinical Development of a Broad Spectrum Antiviral Compound to Treat Human Pa
    Christopher Fisher; Fiscal Year: 2012
    ..It has also been implicated in several other hyperproliferative diseases, such as cancers of the mouth and anus, as well as the upper respiratory and urogenital tracts...
  52. Mechamism of Activation of Oxidative Metabolism in vivo During Exercise
    JESSICA ROSE SPIRES; Fiscal Year: 2012
    ..However, the dynamics of pulmonary oxygen uptake at the mouth are two orders of magnitude slower than intracellular metabolic dynamics...
  53. Porphyromonas gingivalis Horizontal DNA Transfer and Genetic Variation
    Gena D Tribble; Fiscal Year: 2013
    ..research goals are to understand how genetic adaptation allows Porphyromonas gingivalis to persist in the human mouth. If we can understand what methods the bacteria are using to improve their fitness, then we can design better ..
  54. Bone Morphogenetic Protein Controls Links Between Dentinogenesis and Angiogenesis
    Audrey Rakian; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The health of the mouth and the surrounding craniofacial structures is essential to a person's overall health and well-being...
  55. Electron microscopy studies of novel poliovirus genome-releasing intermediates
    Hazel C Levy; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The Picornavirus family includes cardioviruses, foot-and-mouth disease virus, rhinoviruses, hepatitis A virus and enteroviruses...
  56. Creation of adult epithelial stem cells from differentiated epithelial
    Robert A Weinberg; Fiscal Year: 2010
    ..wide range of differentiated epithelial cells, including stratified squamous epithelia, such as the mucosa of the mouth. EMTs effect key morphogenetic steps during various steps of embryonic development...
  57. Development of a canine model of radiotherapy induced oral mucositis
    Dorothy C Brown; Fiscal Year: 2010
    ..is the term for the erythematous, inflammatory, and ulcerative lesions that occur in the mucosal lining of the mouth and pharynx secondary to cytotoxic cancer therapy...
  58. VERTEBRATE PRIMARY MOUTH FORMATION
    Hazel L Sive; Fiscal Year: 2013
    ..The broad goals of this proposal are to understand the mechanisms underlying formation of the vertebrate primary mouth, using the frog Xenopus laevis as a model...
  59. Mouthgard BITES (Behavior, Impulsivity, Theory Evaluation Study)
    DAWN COMSTOCK; Fiscal Year: 2010
    ..15-31, Increase the proportion of public and private schools that require use of appropriate head, face, eye, and mouth protection for students participating in school-sponsored physical activities...
  60. Physical Activity Behavior Among Midlife South Asian Indian Immigrants
    MANJU NARESH DANIEL; Fiscal Year: 2012
    ..of 110 men and women will be recruited through SAI religious institutions, businesses, newspapers, and word of mouth. Physical activity will be assessed by self-report (Community Healthy Activity Model Program for Seniors [CHAMPS] ..
  61. Molecular Heparan Sulfate Delivery in Guided Tissue Regeneration
    Arthur A Decarlo; Fiscal Year: 2010
    ..Barrier membranes are an important adjunct to regeneration therapy aimed at restoring the form and function of the mouth. Commercially available barrier membranes are used in dental surgeries to help retain bone grafting materials, to ..
  62. Ca2+ and secretory dynamics in salivary acinar cells
    David I Yule; Fiscal Year: 2013
    ..provides lubrication, begins nutrient digestion and imparts antimicrobial and mechanical protection for the mouth and upper gastrointestinal tract...
  63. Impact of Receptor Polymorphisms on Sensations from Common Oral Irritants
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..molecular and quantitative behavioral genetics to examine how genetic variation in taste and pain receptors in the mouth may alter response to oral irritants that are commonly found in the food supply...
  64. Oral H. pylori Prevalence in Intellectually/Developmentally Disabled Adults
    Catherine Binkley; Fiscal Year: 2009
    ..Systemic antibiotics are used to treat H. pylori infections but do not appear to eradicate H. pylori in the mouth. The oral status of ID/DD adults is reported to be poor due to inadequate oral hygiene, leading to increased ..
  65. The Vaginal Microbiome: Disease, Genetics and the Environment
    Gregory Buck; Fiscal Year: 2009
    ..second subaim will address the question of whether there is a relationship between the microbiomes of the vagina, mouth and GI tract utilizing samples collected from the DZ and MZ twins. Specific Aim 2...
  66. ORAL CONTROLLED-RELEASE DELIVERY SYSTEMS
    H Rawls; Fiscal Year: 1991
    ..is to demonstrate the feasibility of developing a controlled-release delivery system that can be carried in the mouth. Specifically, the aim is to devise two or more controlled-release antifungal materials as models for delivery ..
  67. PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROME
    SAMUEL HOPKINS; Fiscal Year: 2005
    ..lacrimal and salivary glands by mononuclear cells leads to diminished secretions, with resultant xerostomia (dry mouth) and xeropthalmia (dry eye) being the most prevalent symptoms...
  68. WORKSHOP ON THE ORAL MANIFESTATIONS OF HIV INFECTION
    John Greenspan; Fiscal Year: 2000
    ..All aspects of HIV research as it relates to the mouth will be covered, ranging from basic molecular virology and mycology, through clinical and epidemiological research ..
  69. Oral Home Telecare for Tetraplegics
    Hon K Yuen; Fiscal Year: 2010
    ..The combination of poor oral hygiene performance and dry mouth from xerostomia-causing medications (commonly used in this population) increase the likelihood of dental caries ..
  70. ADULT MEDICAID PATIENTS' DENTAL VISITS IN EDS
    Leonard Cohen; Fiscal Year: 1999
    ..adult Maryland Medicaid patients' patterns of use of hospital emergency departments (EDs) for the treatment of mouth pain and infections associated with teeth and periodontal tissues...
  71. SECOND INT1 WORKSHOP-ORAL MANIFESTION OF HIV INFECTION
    John Greenspan; Fiscal Year: 1993
    ..S.A., notably from Europe, Canada and Central/South America. All aspects of HIV research as it relates to the mouth will be covered, ranging from basic molecular virology and mycology, through clinical and epidemiological research ..
  72. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..One of the planned clinical trials will evaluate the effectiveness of gradually administering peanut allergen by mouth (oral immunotherapy or OIT) on protecting patients from allergic reactions and ultimately curing them of their ..
  73. Hyperbaric O2 Stimulation of Salivary Flow in Radiation -induced Xerostomia
    Michael Martin; Fiscal Year: 2009
    Xerostomia (dry mouth from decreased salivary flow) is an important health problem contributing to poor nutrition (inability to eat), significantly increased rates of dental caries and other oral infections, inability to wear dentures ..
  74. CHEMICAL RELEASE & IMMUNE SENSITIZATION BY DENTAL RESINS
    Anahid Jewett; Fiscal Year: 2002
    ..Resin based materials which polymerize in the mouth are now used by dentists in many ways to help prevent tooth decay and for tooth repair and replacement...
  75. Fundamental Study of Welding Fume Inhalation
    Serap Erdal; Fiscal Year: 2007
    ..be performed using a life-size head and shoulders of a manikin for which breathing will be simulated through the mouth using a ventilator pump...
  76. FOUR TREATMENT STRATEGIES FOR TMJ DISK DISPLACEMENT
    Eric Schiffman; Fiscal Year: 2002
    ..symptomatic, advanced temporomandibular joint (TMJ) disorder: TMJ disk displacement without reduction with limited mouth opening...
  77. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Identical bacteria have been cultured from the mouth and sputum of VAP patients suggesting that the oropharynx of critically ill patients becomes colonized with ..
  78. Intra-Oral Biofilm Formation
    Sigmund Socransky; Fiscal Year: 2004
    ..Thirty randomly selected subjects in each group will receive full mouth "soft tissue cleaning and disinfection...
  79. International collaborative research to develop quantitive sensory testing guidel
    Mark Drangsholt; Fiscal Year: 2009
    ..Findings of taste dysfunction have been reported both for patients with idiopathic orofacial pain and burning mouth syndrome (BMS)...
  80. Statistical Methods for Complex Dependent Dental Data
    David Todem; Fiscal Year: 2006
    ..As an example, it is well believed among dentist that there are spatial symmetries in the mouth with respect to caries, but this has never been shown in a statistical sense...
  81. Miniature, rapid, and 3-dimensional OCT scanner for dental imaging
    GUANGHAI JIN; Fiscal Year: 2009
    ..mirror allows the device to be packaged in a compact form factor compatible with the constrained geometry of the mouth. Agiltron will also incorporate a novel fiber-tip lens to focus the beam, which will enable further ..