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Genomes and Genes | mouthSummarySummary: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper. Top Publications
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Publications
Oral microbial communities in sickness and in healthHoward F Jenkinson
Department of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK
Trends Microbiol 13:589-95. 2005..Understanding the microbial communities that drive sickness or health is a key to combating human oral diseases...
The oral gram-negative anaerobic microflora in young children: longitudinal changes from edentulous to dentate mouthE Kononen
Institute of Dentistry, Department of Periodontology, University of Helsinki, Finland
Oral Microbiol Immunol 9:136-41. 1994..were found in all children at the older age, whereas they occurred in edentulous mouth in 76%, 62%, 67% and 19%, respectively...
The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic informationTsute Chen
The Forsyth Institute, Boston, MA 02115, USA
Database (Oxford) 2010:baq013. 2010..We provide HOMD as a conceptual model for the presentation of microbiome data for other human body sites. Database URL: http://www.homd.org...
Case-control study of human papillomavirus and oropharyngeal cancerAimee R Kreimer
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
N Engl J Med 356:1944-56. 2007..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
Characterization of the oral fungal microbiome (mycobiome) in healthy individualsMahmoud A Ghannoum
Center for Medical Microbiology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
PLoS Pathog 6:e1000713. 2010..This is the first study that identified the "basal mycobiome" of healthy individuals, and provides the basis for a detailed characterization of the oral mycobiome in health and disease...
Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencingZongxin Ling
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
Microb Ecol 60:677-90. 2010....
Neuronal representations of stimuli in the mouth: the primate insular taste cortex, orbitofrontal cortex and amygdalaMikiko Kadohisa
University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
Chem Senses 30:401-19. 2005..Information about the taste, texture of what is in the mouth (viscosity, fat texture and grittiness, which reflect somatosensory inputs), temperature and capsaicin is ..
The oral microbiota: living with a permanent guestMaria Avila
University of California, Merced, 95344, USA
DNA Cell Biol 28:405-11. 2009..How the microbiome of the oral cavity contributes to health and disease is attracting the interest of a growing number of cell biologists, microbiologists, and immunologists...
Immediate effects of atlanto-occipital joint manipulation on active mouth opening and pressure pain sensitivity in women with mechanical neck painPilar Mansilla-Ferragut
Professor, Escuela de Osteopatía de Madrid, Spain
J Manipulative Physiol Ther 32:101-6. 2009..of a spinal thrust manipulation directed to the upper cervical segments (atlanto-occipital joint) on active mouth opening and pressure pain sensitivity in a trigeminal nerve innervated region (sphenoid bone) in women with ..
Artificial mouth model systems and their contribution to caries research: a reviewGaoyan Tang
Oral Biosciences, The Prince Philip Dental Hospital, 34 Hospital Road, The University of Hong Kong, Hong Kong, People's Republic of China
J Dent 31:161-71. 2003..These developments and in particular the in vitro 'artificial mouth' systems have progressed from simple and basic apparatus devised by Magitot and Miller at the end of 19th century ..
Cloning and characterization of an alpha-enolase of the oral pathogen Streptococcus mutans that binds human plasminogenMicheala N Jones
Department of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN 37208, USA
Biochem Biophys Res Commun 364:924-9. 2007..Further studies of this interaction may be critical to understand the pathogenesis of endocarditis caused by S. mutans...
Grasp with hand and mouth: a kinematic study on healthy subjectsM Gentilucci
Istituto di Fisiologia Umana, I 43100 Parma, Italy
J Neurophysiol 86:1685-99. 2001Neurons involved in grasp preparation with hand and mouth were previously recorded in the premotor cortex of monkey...
Molecular investigation of macrolide and Tetracycline resistances in oral bacteria isolated from Tunisian childrenBochra Kouidhi
Laboratoire d Analyses, Traitement et Valorisation des Polluants de l Environnement et des Produits, Faculté de Pharmacie de Monastir, Biologie clinique, Rue Avicenne, 5000 Monastir, Tunisie
Arch Oral Biol 56:127-35. 2011..This study aims to investigate the antibiotic susceptibility of strains isolated from the oral cavity of Tunisian children...
Oral biofilm architecture on natural teethVincent Zijnge
Center for Dentistry and Oral Hygiene, University of Groningen, Groningen, The Netherlands
PLoS ONE 5:e9321. 2010..These in vivo observations on oral biofilms provide a clear vision on biofilm architecture and the spatial distribution of predominant species...
Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouthYann Marcy
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:11889-94. 2007..This approach enables single-cell genetic analysis of any uncultivated minority member of a microbial community...
Carbohydrate in the mouth immediately facilitates motor outputNicholas Gant
Exercise Metabolism Laboratory, University of Auckland, Auckland, New Zealand
Brain Res 1350:151-8. 2010The presence of carbohydrate in the mouth can immediately improve physical performance. How this occurs is not well understood...
Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnessesKennedy Lishimpi
The UNZA-UCLMS (University of Zambia-University College London Medical School) Research and Training Project, Lusaka, Zambia
AIDS 16:932-4. 2002..carinii DNA (sensitivity 68%; specificity 100%; positive predictive value 100%; negative predictive value 87%). This method requires further validation in clinical practice...
Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescentsElaine M Smith
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Pediatr Infect Dis J 26:836-40. 2007..We evaluated the prevalence of HPV DNA in the oral cavity/oropharynx in a cross section of children aged 2 weeks to 20 years...
Effects of a nonsurgical exercise program on the decreased mouth opening in patients with systemic sclerodermaG Pizzo
Department of Oral Sciences, Section of Periodontology, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
Clin Oral Investig 7:175-8. 2003The decreased mouth opening (microstomia) represents a frequent finding in patients with systemic scleroderma (SSD), but little information is available about the efficacy of nonsurgical management of this condition...
Development and validation of a scale for mouth handicap in systemic sclerosis: the Mouth Handicap in Systemic Sclerosis scaleL Mouthon
Department of Internal Medicine, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
Ann Rheum Dis 66:1651-5. 2007To develop and assess the reliability and construct validity of a scale assessing disability involving the mouth in systemic sclerosis (SSc).
Oral functional outcome after intraoral reconstruction with nasolabial flapsE I Hofstra
Department of Plastic Surgery, University Hospital Groningen, Groningen, The Netherlands
Br J Plast Surg 57:150-5. 2004In this study, the functional and aesthetic outcome of patients with nasolabial flaps in the floor of the mouth was examined...
Effects of mouth opening on upper airway collapsibility in normal sleeping subjectsJ C Meurice
Unite de Recherche, Hopital Laval, Universite Laval Quebec, Sainte Foy, Canada
Am J Respir Crit Care Med 153:255-9. 1996We investigated the influence of mouth opening on upper airway (UA) collapsibility in six healthy sleeping volunteers...
The influence of cranio-cervical posture on maximal mouth opening and pressure pain threshold in patients with myofascial temporomandibular pain disordersRoy La Touche
School of Health Science, Department of Physical Therapy, Universidad Europea de Madrid, C Tajo s n, Villaviciosa de Odón, Madrid, Spain
Clin J Pain 27:48-55. 2011The aim of this study was to assess the influence of cranio-cervical posture on the maximal mouth opening (MMO) and pressure pain threshold (PPT) in patients with myofascial temporomandibular pain disorders.
[Normal mouth opening in the adult French population]G Placko
Service de Stomatologie et Chirurgie Maxillo-Faciale du Pr J.-L. Blanc, CHU de la Timone, Marseille
Rev Stomatol Chir Maxillofac 106:267-71. 2005INTRODUCTION: Limitation of mouth opening is a frequent symptom in the pathologies of the temporomandibular joint. The aim of this study is to establish normative basis for this criterion in the French population...
The postural basis of malocclusion: a philosophical overviewJohn R C Mew
London School of Facial Orthotropics, London, United Kingdom
Am J Orthod Dentofacial Orthop 126:729-38. 2004....
On the transformation of sulfur-containing amino acids and peptides to volatile sulfur compounds (VSC) in the human mouthS M Waler
Dental Faculty, University of Oslo, Norway
Eur J Oral Sci 105:534-7. 1997..The other sulfur-containing substrates had much less effect. It was found that the tongue was the major site for VSC production, and that saliva per se caused low VSC production...
Positioning the extreme anterior in Xenopus: cement gland, primary mouth and anterior pituitaryA Dickinson
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, United States
Semin Cell Dev Biol 18:525-33. 2007..In all vertebrates, this region gives rise to the anterior pituitary, the primary mouth and, in most frogs, to the mucus-secreting cement gland...
A clinical study: Melaleuca, Manuka, Calendula and green tea mouth rinseJeffrey D Lauten
Department of Periodontology, School of Dentistry, Oregon Health and Science University, Portland, 97239, USA
Phytother Res 19:951-7. 2005..Larger scale studies would be necessary to determine the efficacy and oral health benefits of the test rinse...
Genetic support for random mating between left and right-mouth morphs in the dimorphic scale-eating cichlid fish Perissodus microlepis from Lake TanganyikaH J Lee
Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Universitatstrasse 10, 78457 Konstanz, Germany
J Fish Biol 76:1940-57. 2010Population genetic analyses were conducted to investigate whether random mating occurs between left and right-mouth morphs of the dimorphic scale-eating cichlid fish Perissodus microlepis from two geographical sites in southern Lake ..
Effect of habitual arecanut chewing on resting whole mouth salivary flow rate and pHT Rooban
Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, 2 102, East Coast Road, Uthandi, Chennai 600 119, India
Indian J Med Sci 60:95-105. 2006Resting whole mouth salivary flow rate (SFR) and pH play a significant role in pathogenesis of various oral diseases and conditions.
Automated fluorescent in situ hybridization for the specific detection and quantification of oral streptococci in dental plaqueT Thurnheer
University of Zurich, Institute of Oral Microbiology and General Immunology, Plattenstrasse 11, 8028 Zurich, Switzerland
J Microbiol Methods 44:39-47. 2001..9 and 1.7%, respectively, of the plaques. The combined application of FISH and automated image analysis provides an objective time-saving alternative to culture or PCR for the enumeration of selected oral streptococci in dental plaque...
Tracheal tube fixation: the effect on depth of insertion of midline fixation compared to the angle of the mouthK Sharma
Department of Anaesthesiology and Intensive Care, Maulana Azad Medical College and Lok Nayak Hospital, New Dehli, India
Anaesthesia 64:383-6. 2009Following successful placement of a tracheal tube (TT), it is frequently moved from the midline to the angle of the mouth. This study investigates the tracheal tube tip position in the two fixation positions in 200 adult patients...
In vitro antimicrobial and resistance-modifying activities of aqueous crude khat extracts against oral microorganismsNezar Al-hebshi
Laboratory of Oral Microbiology, Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
Arch Oral Biol 51:183-8. 2006..To assess antimicrobial activities of aqueous crude khat (Catha edulis) extracts against a panel of oral microorganisms and to test their ability to modify bacterial resistance to tetracycline and penicillin in vitro...
A meta-analysis of children's object-to-mouth frequency data for estimating non-dietary ingestion exposureJianping Xue
USEPA ORD NERL, North Carolina, USA
J Expo Sci Environ Epidemiol 20:536-45. 2010..estimates of non-dietary ingestion in probabilistic exposure modeling, a meta-analysis of children's object-to-mouth frequency was conducted using data from seven available studies representing 438 participants and approximately ..
Detection of hypermethylated RIZ1 gene in primary tumor, mouth, and throat rinsing fluid, nasopharyngeal swab, and peripheral blood of nasopharyngeal carcinoma patientHsiao Wen Chang
Department of Surgery, The University of Hong Kong, Hong Kong, People's Republic of China
Clin Cancer Res 9:1033-8. 2003..evaluated by MSP on CNE-2 and M1 cell lines, 30 tumor biopsies, and their matched body fluid samples, including mouth and throat (M & T) rinsing fluid, NP swabs, plasma, and buffy coat...
Genomics of oral bacteriaMargaret J Duncan
Department of Molecular Genetics, The Forsyth Institute, 140 Fenway, Boston, MA 02115, USA
Crit Rev Oral Biol Med 14:175-87. 2003..The oral microbiota is a unique community especially suited for new challenges to sequence the metagenomes of microbial consortia, and the genomes of uncultivable bacteria...
Lateralized use of the mouth in production of vocalizations by marmosetsM A Hook-Costigan
Department of Psychology, University of Memphis, TN 38152, USA
Neuropsychologia 36:1265-73. 1998..We suggest that hemispheric specializations for communication in humans may well have precursors in primate evolution...
Distribution of selected bacterial species on intraoral surfacesDonna L Mager
Department of Periodontology, The Forsyth Institute, Boston, MA 02115, USA
J Clin Periodontol 30:644-54. 2003..The microbiotas of the soft tissues resembled each other more than the microbiotas that colonized the teeth both above and below the gingival margin...
Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83Karen E Nelson
The Institute for Genomic Research, Rockville, Maryland 20850, USA
J Bacteriol 185:5591-601. 2003..gingivalis can metabolize a range of amino acids and generate a number of metabolic end products that are toxic to the human host or human gingival tissue and contribute to the development of periodontal disease...
Prevalence of Helicobacter pylori detected by polymerase chain reaction in the oral cavity of periodontitis patientsE C E Gebara
Department of Stomatology, Periodontology, University of Sao Paulo, Brazil
Oral Microbiol Immunol 19:277-80. 2004..A full-mouth periodontal examination was performed in every patient and the subjects were allocated to two groups: gingivitis (..
Development of a multispecies oral bacterial community in a saliva-conditioned flow cellJamie S Foster
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, 30 Convent Dr, MSC 4350, Bethesda, MD 20892, USA
Appl Environ Microbiol 70:4340-8. 2004..are dynamic associations of more than 500 bacterial species that form biofilms on the soft and hard tissues of the mouth. Understanding the development and spatial organization of oral biofilms has been facilitated by the use of in ..
The effect of carbohydrate mouth rinse on 1-h cycle time trial performanceJames M Carter
Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
Med Sci Sports Exerc 36:2107-11. 2004PURPOSE AND METHOD: To investigate the possible role of carbohydrate (CHO) receptors in the mouth in influencing exercise performance, seven male and two female endurance cyclists (VO(2max) 63.2 +/- 2.7 (mean +/- SE) mL.kg*(-1)...
Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumoniaMirelle Koeman
University Medical Center Utrecht, Department of Internal Medicine and Dermatology, and Department of Internal Medicine and Intensive Care Medicine, Rijnstate Hospital Arnhem, The Netherlands
Am J Respir Crit Care Med 173:1348-55. 2006..We hypothesized that oral decontamination with either chlorhexidine (CHX, 2%) or CHX/colistin (CHX/COL, 2%/2%) would reduce and postpone development of VAP, and oral and endotracheal colonization...
Periodontal microbial ecologySigmund S Socransky
Department of Periodontology, The Forsyth Institute, Boston, MA, USA
Periodontol 2000 38:135-87. 2005
Defining the normal bacterial flora of the oral cavityJørn A Aas
Institute of Oral Biology, University of Oslo, Postbox 1052 Blindern, 0316 Oslo, Norway
J Clin Microbiol 43:5721-32. 2005..It is important to fully define the human microflora of the healthy oral cavity before we can understand the role of bacteria in oral disease...
Regulation of gene expression in a mixed-genus community: stabilized arginine biosynthesis in Streptococcus gordonii by coaggregation with Actinomyces naeslundiiNicholas S Jakubovics
National Institutes of Health NIDCR, Building 30, Room 310, 30 Convent Drive, Bethesda, MD 20892 4350, USA
J Bacteriol 190:3646-57. 2008..Thus, A. naeslundii stabilizes S. gordonii expression of arginine biosynthesis genes in coaggregates but not cocultures and enables aerobic growth when exogenous arginine is limited...
Inhibition of methicillin-resistant Staphylococcus aureus colonization of oral cavities in newborns by viridans group streptococciY Uehara
Division of Clinical Pathology, Nagano Children s Hospital, Toyoshina, Japan
Clin Infect Dis 32:1399-407. 2001..g., birth weight, diseases) was observed. These results indicate that viridans group streptococci, as bacteria that formerly occupied the oral cavities in newborns, may inhibit later colonization with MRSA...
Methanogenic archaea in health and disease: a novel paradigm of microbial pathogenesisEverly Conway de Macario
Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Columbus Center, Baltimore, MD 21202, USA
Int J Med Microbiol 299:99-108. 2009..the 1970s but their possible role in disease is only emerging now, after they were found in the large intestine, mouth, and vagina...
Actinomyces naeslundii in initial dental biofilm formationI Dige
Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, Aarhus University, Vennelyst Boulevard 9, 8000 Aarhus C, Denmark
Microbiology 155:2116-26. 2009..The participation of A. naeslundii in the initial stages of dental biofilm formation may have important ecological consequences...
Mouth rinse but not ingestion of a carbohydrate solution improves 1-h cycle time trial performanceA Pottier
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
Scand J Med Sci Sports 20:105-11. 2010The aim of the present study was to further explore the influence of ingestion and mouth rinse with a carbohydrate-electrolyte solution (CES) on the performance during a approximately 1 h high-intensity time trial on trained subjects...
Development of oral bacterial flora in young childrenE Kononen
Department of Bacteriology, National Public Health Institute, Helsinki, Finland
Ann Med 32:107-12. 2000..Adhesion is the initial event in the colonization of bacteria. In the mouth, only mucosal surfaces are available during the first months of life...
Condition dependence of nestling mouth colour and the effect of supplementing carotenoids on parental behaviour in the hihi (Notiomystis cincta)John G Ewen
Institute of Zoology, Zoological Society of London, Regents Park, London, UK
Oecologia 157:361-8. 2008..Carotenoid supplementation did, however, result in an increased paternal provisioning rate...
Sex differences in oral asymmetries during wordrepetitionM Hausmann
AE Biopsychologie, Fakultat fur Psychologie, Ruhr Universitat Bochum, Germany
Neuropsychologia 36:1397-402. 1998During speech production the right side of the mouth is opened to a larger degree in most people. This facial asymmetry is thought to be related to a left hemisphere dominance in language processing and/or motor programming...
Left hemisphere cerebral specialization for babies while babblingSiobhan Holowka
Department of Psychology, McGill University, 1205 Dr. Penfield Avenue, , , H3A 1B1, Canada
Science 297:1515. 2002
Communication among oral bacteriaPaul E Kolenbrander
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
Microbiol Mol Biol Rev 66:486-505, table of contents. 2002..A successful search for genes critical for mixed-species community organization will be accomplished only when it is conducted with mixed-species communities...
Air leaking through the mouth during nocturnal nasal ventilation: effect on sleep qualityT J Meyer
Division of Pulmonary and Critical Care Medicine, Lankenau Hospital and Medical Research Center, Wynnewood, Pennsylvania, USA
Sleep 20:561-9. 1997Air leaking through the mouth has been reported in kyphoscoliotic patients receiving nasal ventilation via volume-limited ventilators...
Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteasesEva J Helmerhorst
Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
J Biol Chem 283:19957-66. 2008..The P(1) site being occupied by a Gln residue is a nonarchetype with respect to known proteases and indicates the presence of novel glutamine-specific endoprotease(s) in oral fluid...
Does the condition of the mouth and teeth affect the ability to eat certain foods, nutrient and dietary intake and nutritional status amongst older people?A Sheiham
Department of Epidemiology and Public Health, University College London Medical School, London WC1E 6BT, UK
Public Health Nutr 4:797-803. 2001..To assess how the dental status of older people affected their stated ability to eat common foods, their nutrient intake and some nutrition-related blood analytes...
Clinical assessment of bad breath: current conceptsM Rosenberg
Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Ramat Aviv, Israel
J Am Dent Assoc 127:475-82. 1996Bad breath typically originates in the mouth, often from the back of the tongue...
Mirror neurons responding to the observation of ingestive and communicative mouth actions in the monkey ventral premotor cortexPier Francesco Ferrari
Dipartimento di Neuroscienze, , Via Volturno 39, 43100 Parma, Italy
Eur J Neurosci 17:1703-14. 2003..Here, we describe the mirror responses of F5 neurons that motorically code mouth actions...
Carbohydrate sensing in the human mouth: effects on exercise performance and brain activityE S Chambers
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J Physiol 587:1779-94. 2009Exercise studies have suggested that the presence of carbohydrate in the human mouth activates regions of the brain that can enhance exercise performance but direct evidence of such a mechanism is limited...
The use of oral washes to diagnose Pneumocystis carinii pneumonia: a blinded prospective study using a polymerase chain reaction-based detection systemS Fischer
Department of Laboratory Medicine, Clinical Center, National Institutes of Health and Division of Infectious Diseases, Washington, DC 20892, USA
J Infect Dis 184:1485-8. 2001..These results suggest that oral washes can provide a useful sample for diagnosis of PCP when a sensitive PCR detection system is used...
Microbiological screening for cariogenic bacteria in children 9 to 36 months of ageP Barsamian-Wunsch
Department of Pediatric Dentistry, Dental School, University of Maryland, Baltimore, MD, USA
Pediatr Dent 26:231-9. 2004..Tongue specimens on a swab and mouth mirror were inoculated directly on selective agar media (MS only)...
Does assessment of microbial composition of plaque/saliva allow for diagnosis of disease activity of individuals?G H Bowden
Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada
Community Dent Oral Epidemiol 25:76-81. 1997....
Genotypic and phenotypic analysis of Streptococcus mutans from different oral cavity sites of caries-free and caries-active childrenF L Lembo
Department of Microbiology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Oral Microbiol Immunol 22:313-9. 2007..This study aimed to determine the number and distribution of genotypes of S. mutans isolated from caries-active and caries-free children and to evaluate some of their phenotypic traits...
Time of initial acquisition of mutans streptococci by human infantsFlavia Martao Florio
Piracicaba School of Dentistry, State University of Campinas, Piracicaba, Sao Paulo Brazil
J Clin Pediatr Dent 28:303-8. 2004..After 24 months, there were no dental caries, and 77% of children remained caries-free. These results indicate that MS colonization in this sample of low-income pre-school children may begin earlier than suggested by some investigations...
The antimicrobial effect of a triclosan/copolymer dentifrice on oral microorganisms in vivoDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, NJ 07103, USA
J Am Dent Assoc 137:1406-13. 2006..The authors compared the in vivo antimicrobial effects on microorganisms from dental plaque, saliva and the tongue in subjects who used a triclosan/copolymer dentifrice and a fluoride dentifrice (control)...
Microflora in oral ecosystems in subjects with hyposalivation due to medicines or of unknown originAnnica Almståhl
The Sahlgrenska Academy at Goteborg University, Faculty of Odontology, 405 30 Goteborg, Sweden
Oral Health Prev Dent 3:67-76. 2005..To analyse the microbial flora in specific sites in 20 dentate (> or = 16 teeth) subjects with hyposalivation due to medicines or of unknown origin and in 20 controls matched according to age, sex and number of teeth...
In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodiesFang Gu
School of Dentistry and Dental Research Institute, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, United States
J Microbiol Methods 62:145-60. 2005..These studies indicate that MAbs based bacterial detection with CLSM is a versatile tool which permits new insights into the ecology of oral biofilm development...
Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formationA Yamanaka
Department of Microbiology, Tokyo Dental College, Chiba, Japan
Oral Microbiol Immunol 19:150-4. 2004..The present findings suggest that cranberry juice component(s) can inhibit colonization by oral streptococci to the tooth surface and can thus slow development of dental plaque...
Isolation of bacteriophages from the oral cavityG Hitch
Microbiology Group, School of Pharmacy, University of London, London, UK
Lett Appl Microbiol 39:215-9. 2004..Antibacterial substances derived from some members of the oral microflora warrant investigation as potential antibiotics...
Passive immunization with milk produced from an immunized cow prevents oral recolonization by Streptococcus mutansY Shimazaki
Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan
Clin Diagn Lab Immunol 8:1136-9. 2001..S. mutans levels in saliva and dental plaque decreased after CPC treatment in both groups. Mouth rinsing with immune milk significantly inhibited recolonization of S. mutans in saliva and plaque...
Bond strengthening in oral bacterial adhesion to salivary conditioning filmsHenny C van der Mei
Department of Biomedical Engineering, University Medical Center Groningen, and University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Appl Environ Microbiol 74:5511-5. 2008..After bond strengthening, bacterial adhesion forces with a salivary conditioning film remained stronger than those with BSA coatings...
Comparative study of the effects of two bleaching agents on oral microbiotaYara Tardelli Alkmin
School of Dentistry, Herminio Ometto University Center (UNIARARAS, Araras-SP, Brazil
Oper Dent 30:417-23. 2005..05). The Mann Whitney nonparametric test (alpha=0.05) showed no differences in micro-organism counts for both agents (p>0.05). Different bleaching agents did not change the oral cavity mutans Streptococcus counts...
Chitosan-containing gum chewing accelerates antibacterial effect with an increase in salivary secretionY Hayashi
Department of Cariology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1 7 1, Nagasaki 852 8588, Japan
J Dent 35:871-4. 2007..designed to confirm the mechanical efficacy of chewing chitosan-containing gum to suppress the growth of oral bacteria compared to a mouth rinse, and to demonstrate the increased salivary secretion due to chewing chitosan-containing gum.
[Analysis of oral microflora early colonized in infants]Jing Zou
Dept. of Pediatric Dentistry, West China College of Stomatology, Sichuan University, Chengdu 610041, China
Hua Xi Kou Qiang Yi Xue Za Zhi 22:126-8. 2004..is the first and the most anaerobic species appeared in oral cavity of healthy babies. A. odontolyticus is the first actinomyces detected in oral cavity. With the increasing months, kind and amount of microflora increase dramatically...
High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patientsMakoto Umeda
Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Periodontol 74:129-34. 2003..The purpose of this study was to use nested polymerase chain reaction (PCR) to clarify whether the oral cavity acts as a reservoir for H. pylori...
[Full mouth one stage disinfection of the oropharynx. A new treatment strategy for periodontitis]M De Soete
Afdeling Parodontologie van de School voor Tandheelkunde, Mondziekten en Kaakchirurgie, Faculteit Geneeskunde, van de Katholieke Universiteit Leuven, Belgie
Ned Tijdschr Tandheelkd 109:434-8. 2002..translocation of these pathogens between these niches is possible, a 'one stage' disinfection of the whole mouth in one or two consecutive days as treatment strategy for periodontal infections must be considered...
HLA-DR4 and salivary immunoglobulin A reactions to oral streptococciM L Wallengren
Department of Cariology, Faculty of Odontology, , Sweden
Oral Microbiol Immunol 16:45-53. 2001..mutans colonisation and serologically defined DR4 positive subjects might be explained by the heterogeneity in this group, and the relation should be sought on a subgroup level...
Periodontal and oral microbiological status of an adult population undergoing haemodialysis: a cross-sectional studyA Castillo
Department of Microbiology, Schools of Medicine and Dentistry, University of Granada, E 18071 Granada, Spain
Oral Dis 13:198-205. 2007..The aim of this cross-sectional study was to evaluate the periodontal status and oral microbiological patterns of a population with end-stage renal disease (ESRD), undergoing haemodialysis (HD)...
Stress as a determinant of saliva-mediated adherence and coadherence of oral and nonoral microorganismsJos A Bosch
Department of Dental Basic Sciences (J.A.B, M.T, K.N, E.C.I.V, A.V.N.A, Section Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands
Psychosom Med 65:604-12. 2003..This study hereby presents a mechanism by which stress may affect the mucosal microflora and susceptibility to infectious disease...
Individual vitality pattern of in situ dental biofilms at different locations in the oral cavityN B Arweiler
Department of Operative Dentistry and Periodontology, Albert Ludwigs University, Hugstetter Strasse 55, DE 79106 Freiburg, Germany
Caries Res 38:442-7. 2004..Nevertheless, the analysis of the data of each single volunteer revealed a very similar vitality pattern in all twelve locations...
Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutansFrancesca Berlutti
Department of Public Health Sciences, University of Rome La Sapienza, Italy
Biometals 17:271-8. 2004..mutans free, aggregated or biofilm on abiotic surfaces. Both these activities of lactoferrin, related and unrelated to the iron binding capability, could have a key role in protecting the human oral cavity from S. mutans pathogenicity...
Involvement of antigen I/II surface proteins in Streptococcus mutans and Streptococcus intermedius biofilm formationD Pecharki
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
Oral Microbiol Immunol 20:366-71. 2005..Oral streptococci including S. mutants and S. intermedius express a family of surface proteins termed antigen I/II (Ag I/II). Ag I/II is implicated in adhesion; however, its role in biofilm formation has not yet been investigated...
Variation in bacterial DGGE patterns from human saliva: over time, between individuals and in corresponding dental plaque microcosmsIndira A Rasiah
Dental Research Group, Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, P.O. Box 7343, Wellington 6039, New Zealand
Arch Oral Biol 50:779-87. 2005..16S rDNA fingerprints of human saliva and dental plaque microcosm biofilms grown in the multi-plaque artificial mouth (MAM) were characterised using denaturing gradient gel electrophoresis (DGGE)...
Effect of maternal use of chewing gums containing xylitol, chlorhexidine or fluoride on mutans streptococci colonization in the mothers' infant childrenIngrid Thorild
Public Dental Clinic, Varberg, Sweden
Oral Health Prev Dent 1:53-7. 2003..CONCLUSION: Maternal consumption of xylitol- and chlorhexidine/xylitol-containing chewing gums significantly reduced the mother-child transmission of salivary mutans streptococci...
A longitudinal study of Streptococcus mutans colonization in infants after tooth eruptionA K L Wan
University of Queensland, School of Dentistry, 200 Turbot Street, Brisbane, Queensland 4000, Australia
J Dent Res 82:504-8. 2003..mutans was associated with toothbrushing (p < 0.03) and multiple courses of antibiotics (p < 0.001). Analysis of our data establishes the timing of S. mutans colonization in children from birth to 24 mos of age...
Efficacy of three surface disinfectants for dental radiographic films and glovesM M Coogan
Division of Oral Microbiology, Department of Clinical Microbiology and Infectious Diseases, University of the Witwatersrand, Johannesburg, Private Bag 3, Wits 2050, South Africa
J Dent 32:385-9. 2004..PVPI killed 99.8% and AIP spray between 95.8 and 99% of microorganisms. Conclusions. NaDC was the most successful disinfectant in the laboratory and clinical setting followed by PVPI and AIP...
The effect of saliva or serum on bacterial and Candida albicans colonization on type I collagenH Nikawa
Department of Prosthetic Dentistry, Hiroshima University Faculty of Dentistry, Hiroshima, Japan
J Oral Rehabil 33:767-74. 2006....
Relationship between feeding habits and mutans streptococci colonization in a group of Spanish children aged 15-20 monthsMarta Lamas
Community Health Center, Collado Villalba, Madrid, Spain
Am J Dent 16:9A-12A. 2003..1) To determine the prevalence of mutans streptococci (MS) in a group of Spanish children aged 15-20 months, and (2) to analyze the relationship between early colonization and feeding habits...
Streptococcal diversity in oral biofilms with respect to salivary functionJ D Rudney
Department of Oral Science, School of Dentistry, University of Minnesota, 17 252 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA
Arch Oral Biol 48:475-93. 2003..Caries scores were significantly lower in both High Aggregation-Adherence groups. In this study we looked at the effects of those differences in salivary function on the quantity and diversity of oral biofilm streptococci...
Mycological and cytological examination of oral candidal carriage in diabetic patients and non-diabetic control subjects: thorough analysis of local aetiologic and systemic factorsT Kadir
Department of Microbiology, Marmara University, Istanbul, Turkey
J Oral Rehabil 29:452-7. 2002..pH, heredity, alcohol drinking, smoking habits, antimicrobial therapy, wearing of denture, burning sensation, dry mouth, taste alteration and tooth brushing habit on candidal carriage rate were investigated...
Oral nitric oxide during plaque depositionS Carossa
Prosthodontic Department, University of Torino, Italy via Genova 3, 10126 Turin, Italy
Eur J Clin Invest 31:876-9. 2001..046). CONCLUSIONS: Oral NO production increases during de novo deposition of dental plaque. NO might be an early host defence mechanism against bacterial proliferation in the plaque. Such a mechanism is inhibited by cigarette smoking...
Microbiological evaluation of dental unit water systems in general dental practice in EuropeJ T Walker
Health Protection Agency, Porton Down, Salisbury, UK
Eur J Oral Sci 112:412-8. 2004..The study emphasizes the need for effective mechanisms to reduce the microbial burden within DUWS, and highlights the risk of occupational exposure and cross-infection in general dental practice...
Plasma and salivary amoxicillin concentrations and effect against oral microorganismsS Baglie
Department of Pharmaceutical Sciences, Ponta Grossa State University, Ponta Grossa, PR, Brazil
Int J Clin Pharmacol Ther 45:556-62. 2007..05) but all microorganism counts at 60 min post-dose showed a significant decrease (p < 0.05). Amoxicillin was effective in reducing oral microorganism levels up to 12 h post-dose...
Diabetes mellitus as a contributory factor in oral candidosisN S Soysa
Division of Pharmacology, Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka
Diabet Med 23:455-9. 2006..Hence, we review and discuss here the clinical data in the literature on the relationship between diabetes and oral candidal carriage and infection, and possible mechanisms associated with its pathogenicity...
One-year follow-up of the effect of fixed orthodontic treatment on colonization by oral CandidaSeher Gündüz Arslan
Department of Orthodontics, Dental Faculty, Dicle University Diyarbakier, Turkey
J Oral Pathol Med 37:26-9. 2008..The results indicate that the prevalence of oral Candida spp. is high in young adults in south-eastern Turkey and that the Candida counts increase when braces are involved...
Dental caries, oral hygiene, and oral clearance in children with craniofacial disordersM Ahluwalia
Dental Caries Research Group, Guy's, King's and St Thomas' Dental Institute, Caldecot Road, Denmark Hill, London, England. SE5 9RW
J Dent Res 83:175-9. 2004..The longer oral clearance times of foods and the consequent generation of fermentable sugars from starches may contribute to the higher caries prevalence observed in children with cleft palates...
Biofilm formation of Candida albicans is variably affected by saliva and dietary sugarsYe Jin
Faculty of Dentistry, The University of Hong Kong, Oral Biosciences, 5/F, Prince Philip Dental Hospital 34, Hong Kong, Hong Kong
Arch Oral Biol 49:789-98. 2004..To conclude, biofilm formation of C. albicans within the oral milieu appears to be modulated to varying extents by dietary and salivary factors and, further investigations are required to elucidate these complex interactions...
One-stage full-mouth disinfection. Long-term microbiological results analyzed by checkerboard DNA-DNA hybridizationM De Soete
Catholic University of Leuven, Faculty of Medicine, School of Dentistry, Oral Pathology and Maxillo-Facial Surgery, Department of Periodontology, Belgium
J Periodontol 72:374-82. 2001..clinical and microbiological improvements when severe adult periodontitis was treated via the one-stage full-mouth (OSFM) disinfection approach, instead of a standard treatment scheme with staged instrumentation per quadrant...
The distribution of stimulated saliva in childrenS T McDonnell
Department of Oral Health and Development, University Dental School and Hospital, National University of Ireland, Cork
Int J Paediatr Dent 11:417-23. 2001..It is not only the quantity that is important, but also how the saliva is distributed once it enters the mouth. Several studies have looked at how saliva is distributed around adult mouths...
Research Grants
- TASTE PSYCHOPHYSICSLinda Bartoshuk; Fiscal Year: 2003..oral phantoms (sensations in the absence of stimulation); these occur for taste (dysgeusia) and oral pain (burning mouth syndrome)...
- IL-4 Signaling Pathway Regulation of Sjogren's SyndromeAMMON PECK; Fiscal Year: 2004..specific anti-nuclear autoantibodies, loss of stimulated fluid secretion, and complaints of dry eyes and/or dry mouth. Over the past several years, the NOD mouse has been shown to exhibit numerous disease manifestations that ..
- Role of the OPI1 gene in controlling viability of Candida glabrataTODD REYNOLDS; Fiscal Year: 2007..albicans (41.3% and 48.8%, respectively). C. glabrata is favored in patients with dryness of mouth, which is a side effect associated with medications or conditions frequently found in the elderly...
- Intra vs. extracortical command signals to restore six dimensional hand movementsDAWN MARIE TAYLOR; Fiscal Year: 2010..their arm and hand just by thinking about doing so while also allowing them to retain normal use of their face and mouth. Two main types of implanted brain recording technologies are being developed and commercialized for chronic human ..
- The Role of Glycolipids and CD1 in the Immunology of Leishmania InfectionLaurence U Buxbaum; Fiscal Year: 2010..parasites cause fatal disease of the internal organs as well as non-healing and disfiguring diseases of the skin, mouth, and nose...
- SALIVARY IMMUNE RESPONSE TO COMMENSAL ORAL BACTERIAMichael Cole; Fiscal Year: 1993At birth pioneer bacterial colonize the mouth and are succeeded by other populations to form the normal flora which plays an important role in host defense by excluding exogenous pathogens...
- PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROMESAMUEL HOPKINS; Fiscal Year: 2005..lacrimal and salivary glands by mononuclear cells leads to diminished secretions, with resultant xerostomia (dry mouth) and xeropthalmia (dry eye) being the most prevalent symptoms...
- EFFECTS OF RETINOIDS ON SQUAMOUS CELL CARCONOMASLorraine Gudas; Fiscal Year: 1993..The normal human epithelial cell strains that will be analyzed include those from the soft palate, floor of mouth, buccal mucosa, ventral tongue, gingiva, hard palate, and facial epidermis...
- Tongue-pressure timing for liquid flow detection and control in swallowingCATRIONA MARGARET STEELE; Fiscal Year: 2010..The tongue plays a critical role in containing liquids in the mouth, and in directing and controlling flow through the pharynx (throat)...
- Novel Antibacterial Fluoride-releasing Dental MaterialsXiaoming Xu; Fiscal Year: 2010..high caries-risk, portion of the population: the medically-compromised who suffer from xerostomia or dry mouth (due to Sjvgren's syndrome, diabetes, head and neck irradiation, and medications), children, the elderly, and ..
- Palliation of Thirst in Intensive Care Unit PatientsKathleen Puntillo; Fiscal Year: 2009..The intervention is a combination therapy treatment (CTT) for thirst that includes the use of sterile water mouth sprays, sterile water swabs, and menthol-based lip and tongue moisturizer...
- Palliation of Thirst in Intensive Care Unit PatientsKathleen A Puntillo; Fiscal Year: 2010..The intervention is a combination therapy treatment (CTT) for thirst that includes the use of sterile water mouth sprays, sterile water swabs, and menthol-based lip and tongue moisturizer...
- CHEMICAL RELEASE & IMMUNE SENSITIZATION BY DENTAL RESINSAnahid Jewett; Fiscal Year: 2002..Resin based materials which polymerize in the mouth are now used by dentists in many ways to help prevent tooth decay and for tooth repair and replacement...
- CHEMICAL RELEASE & IMMUNE SENSITIZATION BY DENTAL RESINSWyatt Hume; Fiscal Year: 2001..Resin based materials which polymerize in the mouth are now used by dentists in many ways to help prevent tooth decay and for tooth repair and replacement...
- Metgagenomic Analysis of the Human Oral Viral MicrobiomeDerrick Fouts; Fiscal Year: 2007..examination of their genome sequences will unveil new clues to the role of viruses in the microbial ecology of the mouth (e.g. biofilm formation and disease)...
- APD to Measure the Resistance of the Respiratory SystemJAFAR VOSSOUGHI; Fiscal Year: 2007..in concept, employing a rotating wheel in the flow path to change flow by 20-45%, with associated small changes in mouth pressure. From these changes, resistance is calculated...
- NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINSFrances Walker; Fiscal Year: 2002..This protein has been found to be unique in terms of structure (a beta-barrel with a heme in its mouth), reduction potential and resistance to autoreduction in the presence of excess NO...
- VERTEBRATE PRIMARY MOUTH FORMATIONHazel L Sive; Fiscal Year: 2010The broad goals of this proposal are to understand the mechanisms underlying formation of the vertebrate primary mouth, using the frog Xenopus laevis as a model...
- Fundamental Study of Welding Fume InhalationSerap Erdal; Fiscal Year: 2007..be performed using a life-size head and shoulders of a manikin for which breathing will be simulated through the mouth using a ventilator pump...
- Molecular Biology of Oral Alkali ProductionROBERT BURNE; Fiscal Year: 2005..There are two major sources of ammonia in the mouth: urea and arginine, which are hydrolyzed by ureases and the arginine deiminase system (ADS) of oral bacteria, ..
- FOUR TREATMENT STRATEGIES FOR TMJ DISK DISPLACEMENTEric Schiffman; Fiscal Year: 2002..symptomatic, advanced temporomandibular joint (TMJ) disorder: TMJ disk displacement without reduction with limited mouth opening...
- Oral Care and Respiratory Pathogen ColonizationOzan Akca; Fiscal Year: 2004..Identical bacteria have been cultured from the mouth and sputum of VAP patients suggesting that the oropharynx of critically ill patients becomes colonized with ..
- Intra-Oral Biofilm FormationSigmund Socransky; Fiscal Year: 2004..Thirty randomly selected subjects in each group will receive full mouth "soft tissue cleaning and disinfection...
- Statistical Methods for Complex Dependent Dental DataDavid Todem; Fiscal Year: 2006..As an example, it is well believed among dentist that there are spatial symmetries in the mouth with respect to caries, but this has never been shown in a statistical sense...
- Contribution of Inhalation for Human Smoke ExposureWallace Pickworth; Fiscal Year: 2007..tissue, quantitative measures of smoke exposure are ordinarily indexed by puffing parameters - measures of mouth exposure...
