macula lutea

Summary

Summary: An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)

Top Publications

  1. ncbi Optical coherence tomography evaluation of detached macula from rhegmatogenous retinal detachment and central serous chorioretinopathy
    Sun Young Lee
    Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong, Songpa Gu, Seoul, Korea
    Am J Ophthalmol 145:1071-1076. 2008
  2. ncbi Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
  3. ncbi Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
  4. ncbi Dome-shaped macula in eyes with myopic posterior staphyloma
    David Gaucher
    Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Service d Ophtalmologie, Universite Paris 7, Paris, France
    Am J Ophthalmol 145:909-14. 2008
  5. ncbi Comparison of three different optical coherence tomography models for total macular thickness measurements in healthy controls
    Marcel N Menke
    Department of Ophthalmology, University of Zurich, Frauenklinikstrasse 24 CH 8091 Zürich, Switzerland
    Ophthalmologica 223:352-6. 2009
  6. ncbi Macular hole formation: new data provided by optical coherence tomography
    A Gaudric
    Department of Ophthalmology, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite Paris 7, France
    Arch Ophthalmol 117:744-51. 1999
  7. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
  8. ncbi A method of drusen measurement based on the geometry of fundus reflectance
    R Theodore Smith
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Biomed Eng Online 2:10. 2003
  9. ncbi Serous macular detachment associated with retinal arterial macroaneurysm
    Kyoichi Takahashi
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Jpn J Ophthalmol 50:460-4. 2006
  10. ncbi Natural course of macular retinoschisis in highly myopic eyes without macular hole or retinal detachment
    Noriaki Shimada
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
    Am J Ophthalmol 142:497-500. 2006

Research Grants

  1. Absolute Fundus Autofluorescence in Retinal Degenerations
    ROLAND THEODORE SMITH; Fiscal Year: 2010
  2. Biomedical Image Engineering of Macular Images
    R Smith; Fiscal Year: 2007
  3. Biomedical Image Engineering of Macular Images
    ROLAND SMITH; Fiscal Year: 2009
  4. Central Scotomas in AMD and Cortical Remapping
    Janet Sunness; Fiscal Year: 2005
  5. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2006
  6. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2007
  7. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2009
  8. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2010
  9. Early Retinal Disease Detection Using Standard And Novel Retinal Imaging Techniqu
    DEAN VANNASDALE; Fiscal Year: 2007
  10. Perceptual encoding and imagery in prosopagnosia
    Jason Barton; Fiscal Year: 2007

Detail Information

Publications223 found, 100 shown here

  1. ncbi Optical coherence tomography evaluation of detached macula from rhegmatogenous retinal detachment and central serous chorioretinopathy
    Sun Young Lee
    Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong, Songpa Gu, Seoul, Korea
    Am J Ophthalmol 145:1071-1076. 2008
    ..To compare structural changes using optical coherence tomography (OCT) and visual acuity (VA) loss in patients with shallow macula-off rhegmatogenous retinal detachment (RD) and central serous chorioretinopathy (CSC) involving the macula...
  2. ncbi Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  3. ncbi Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
    ..The best reproducibility was found for dilated standard scanning for NFL and ONH parameters and for dilated high-density scanning for macular parameters...
  4. ncbi Dome-shaped macula in eyes with myopic posterior staphyloma
    David Gaucher
    Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Service d Ophtalmologie, Universite Paris 7, Paris, France
    Am J Ophthalmol 145:909-14. 2008
    ..To describe an unusual feature in myopic eyes responsible for visual loss, which we call a dome-shaped macula...
  5. ncbi Comparison of three different optical coherence tomography models for total macular thickness measurements in healthy controls
    Marcel N Menke
    Department of Ophthalmology, University of Zurich, Frauenklinikstrasse 24 CH 8091 Zürich, Switzerland
    Ophthalmologica 223:352-6. 2009
    ..The purpose of this study was to compare 3 commercially available OCT models for retinal thickness measurements in healthy controls...
  6. ncbi Macular hole formation: new data provided by optical coherence tomography
    A Gaudric
    Department of Ophthalmology, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite Paris 7, France
    Arch Ophthalmol 117:744-51. 1999
    ..To establish the sequence of events leading from vitreofoveal traction to full-thickness macular hole formation...
  7. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
    ..This may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve, in secondary progressive MS and primary progressive MS...
  8. ncbi A method of drusen measurement based on the geometry of fundus reflectance
    R Theodore Smith
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Biomed Eng Online 2:10. 2003
    ..Current manual methods of drusen measurement are laborious and subjective. Our purpose was to expedite clinical research with an accurate, reliable digital method...
  9. ncbi Serous macular detachment associated with retinal arterial macroaneurysm
    Kyoichi Takahashi
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Jpn J Ophthalmol 50:460-4. 2006
    ..To report optical coherence tomography (OCT) findings of macular edema secondary to retinal arterial macroaneurysms...
  10. ncbi Natural course of macular retinoschisis in highly myopic eyes without macular hole or retinal detachment
    Noriaki Shimada
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
    Am J Ophthalmol 142:497-500. 2006
    ..CONCLUSIONS: These findings suggest that macular retinoschisis might be a progressive condition, and that complications appeared to be related to the presence of vitreoretinal tractions...
  11. ncbi Distribution of macular thickness by optical coherence tomography: findings from a population-based study of 6-year-old children
    Son C Huynh
    Department of Ophthalmology, the University of Sydney and the Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Sydney, Australia
    Invest Ophthalmol Vis Sci 47:2351-7. 2006
    ..Significant gender and ethnic differences were demonstrated. Axial length and refraction were important ocular biometric determinants of macular thickness...
  12. ncbi Optical coherence tomographic evaluation of macular infarction following dapsone overdose
    Nazimul Hussain
    Smt Kanuri Santhamma Retina Vitreous Centre, L V Prasad Eye Institute, Hyderabad, India
    Indian J Ophthalmol 54:271-2. 2006
    ..Hence, OCT could show the progression of foveal atrophy from cystic macular edema following dapsone poisoning...
  13. ncbi Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (spectralis)
    Sandeep Grover
    Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL32209, USA
    Am J Ophthalmol 148:266-71. 2009
    ..To establish normative data for the macular thickness by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease...
  14. ncbi Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 47:2305-16. 2006
    ....
  15. ncbi Classifying and grading retinal signs in severe malaria
    S P Harding
    St Paul's Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Trop Doct 36:1-13. 2006
  16. ncbi Temporal variation in diabetic macular edema measured by optical coherence tomography
    Robert N Frank
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ophthalmology 111:211-7. 2004
    ..To determine, by optical coherence tomography (OCT), whether there is a quantitative decrease in macular edema in diabetic subjects over the course of a day...
  17. ncbi Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Mass 02111-1533, USA
    Arch Ophthalmol 124:193-8. 2006
    ..This discrepancy should be considered when interpreting OCT scans...
  18. ncbi Diurnal variation in clinically significant diabetic macular edema measured by the Stratus OCT
    Antonio Polito
    Department of Ophthalmology, University of Udine, Italy
    Retina 26:14-20. 2006
    ..However, in our study, the entity of this decline was relatively small and not relevant from a clinical standpoint...
  19. ncbi Heritability of macular thickness determined by optical coherence tomography
    Matthew D Chamberlain
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Invest Ophthalmol Vis Sci 47:336-40. 2006
    ..To examine whether genetic factors significantly influence macular thickness in healthy older subjects...
  20. ncbi Central retinal thickness is positively correlated with macular pigment optical density
    S H Melissa Liew
    Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, UK
    Exp Eye Res 82:915-20. 2006
    ..This finding has important implications for future studies investigating MPOD, and its response to dietary modification/supplementation...
  21. ncbi Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration
    Jan M Provis
    Research School of Biological Sciences, The Australian National University, GPO Box 475, Canberra, ACT, 2601, Australia
    Clin Exp Optom 88:269-81. 2005
    ..Both the inflammatory response and the sequelae of oxidative stress are predictable outcomes in this scenario...
  22. ncbi Comparison of epiretinal membranes of differing pathogenesis using optical coherence tomography
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical School, 38 Morohongo, Moroyama, Iruma, Saitama 350 0495, Japan
    Retina 24:57-62. 2004
    ..To compare optical coherence tomography (OCT) images of idiopathic epiretinal membranes (ERMs) with those of secondary ERMs...
  23. ncbi Regional variations in the relationship between macular thickness measurements and myopia
    Dennis Shun Chiu Lam
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
    Invest Ophthalmol Vis Sci 48:376-82. 2007
    ..To investigate the relationship between myopia and macular thickness, as measured by optical coherence tomography...
  24. ncbi Ethnic differences in macular pigment density and distribution
    Ute E K Wolf Schnurrbusch
    Klinik und Poliklinik für Augenheilkunde, Inselspital, University Bern, Bern, Switzerland
    Invest Ophthalmol Vis Sci 48:3783-7. 2007
    ..In this study, the authors investigate ethnic differences in macular pigment density (MPD) and macular pigment (MP) distribution...
  25. ncbi Microperimetric assessment of patients with type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 48:3788-95. 2007
    ..To assess changes of the light increment sensitivity (LIS) of the macular area in patients with type 2 idiopathic macular telangiectasia (IMT)...
  26. ncbi Macular thickness measurements in normal eyes with time-domain and Fourier-domain optical coherence tomography
    Jingjing Huang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Retina 29:980-7. 2009
    ..To compare macular thickness measurements using time-domain optical coherence tomography (OCT) and Fourier-domain OCT...
  27. ncbi Quality issues in interpretation of optical coherence tomograms in macular diseases
    Amitha Domalpally
    Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
    Retina 29:775-81. 2009
    ..To analyze the scan characteristics associated with poor-quality Stratus optical coherence tomograms submitted to a reading center for multicenter clinical trials...
  28. ncbi Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 89:25-31. 2009
    ..This disease might serve as a model to further study abnormalities of MP distribution in retinal disorders and to elucidate the mechanisms of MP deposition in the retina...
  29. ncbi Differential expression of anti-angiogenic factors and guidance genes in the developing macula
    Peter Kozulin
    ARC Centre of Excellence in Vision Science and School of Biology, The Australian National University, Canberra, Australia
    Mol Vis 15:45-59. 2009
    ..The aim of this study was to identify novel genes that may influence retinal vascular patterning and definition of the foveal avascular area...
  30. ncbi Causes of macular serous retinal detachments in Japanese patients 40 years and older
    Taiichi Hikichi
    Ohtsuka Eye Hospital, Sapporo, Japan
    Retina 29:395-404. 2009
    ..To investigate the causes of macular serous retinal detachment without hemorrhage at the macula in patients 40 years and older...
  31. ncbi Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
    Zhenglin Yang
    Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, China
    N Engl J Med 359:1456-63. 2008
    ..Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown...
  32. ncbi Analysis of macular thickness in British population using optical coherence tomography (OCT): an emphasis on interocular symmetry
    Mohamed El-Ashry
    Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom
    Curr Eye Res 33:693-9. 2008
    ..To evaluate macular thickness measurements in normal subjects from British origin, to assess interocular asymmetry using optical coherence tomography (OCT) and to establish standard values for macular and foveal thickness...
  33. ncbi Macular complications on the border of an inferior staphyloma associated with tilted disc syndrome
    Hideo Nakanishi
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Retina 28:1493-501. 2008
    ..To describe the clinical characteristics of macular complications on the border of an inferior staphyloma associated with tilted disk syndrome...
  34. ncbi Macular thickness assessment in healthy eyes based on ethnicity using Stratus OCT optical coherence tomography
    Patrick J Kelty
    Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 49:2668-72. 2008
    ..To assess the variation in macular thickness measurements in healthy Caucasian and African American men and women through Stratus OCT optical coherence tomography (OCT-3)...
  35. ncbi Pattern of macular thickness changes measured by ocular coherence tomography in patients with multiple sclerosis
    K Gugleta
    Outpatient Neurology Clinic, University Hospital Basel, Basel, Switzerland
    Klin Monbl Augenheilkd 225:408-12. 2008
    ..An analysis of the pattern of retinal thickness changes in macula in patients with multiple sclerosis (MS) was performed...
  36. ncbi Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:1172-7. 2008
    ..To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT)...
  37. ncbi Analysis of retinal nerve fiber layer and macular thickness measurements in healthy Taiwanese individuals using optical coherence tomography (Stratus OCT)
    Sheng Yao Hsu
    Department of Ophthalmology, Buddhist Tzu Chi General Hospital and Institute of Medicine Science and Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan
    J Glaucoma 17:30-5. 2008
    ..To investigate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) and macular thickness measurements in healthy Taiwanese subjects using optical coherence tomography (Stratus OCT)...
  38. ncbi Macular infarction after intravitreal ganciclovir injection in a patient with acute retinal necrosis
    Seong-Woo Kim
    Can J Ophthalmol 43:124-5. 2008
  39. ncbi Racial differences in macular thickness in healthy eyes
    Baharak Asefzadeh
    VA Boston Healthcare System, Eye Clinic, Jamaica, Plain, Massachusetts 02130, USA
    Optom Vis Sci 84:941-5. 2007
    ..In this study, we compared macular thickness in healthy eyes of black and white subjects using optical coherence tomography (Stratus OCT)...
  40. ncbi Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane
    Simone S van Soest
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences KNAW, Meibergdreef, Amsterdam, The Netherlands
    Mol Vis 13:1608-17. 2007
    ..To describe gene expression differences between healthy, young human retinal pigment epithelium (RPE) cells from the macular area and RPE cells from two locations in the retinal periphery...
  41. ncbi Patients with Sjögren-Larsson syndrome lack macular pigment
    Rob L P VAN DER Veen
    University Eye Clinic, Maastricht, The Netherlands
    Ophthalmology 117:966-71. 2010
    ..Ophthalmic symptoms in SLS are reduced visual acuity and photophobia. This article reports the deficiency of macular pigment as a novel finding in this peculiar, congenital maculopathy...
  42. ncbi Paramacular coloboma
    Debi Pian
    VA Greater Los Angeles Healthcare System, Santa Barbara Community-Based Outpatient Clinic, Santa Barbara, CA, USA
    Optom Vis Sci 80:556-63. 2003
    ..Differential diagnosis is important because the clinical appearance can be similar to acquired conditions, most notably age-related macular degeneration and presumed ocular histoplasmosis syndrome...
  43. ncbi Repeatability and reproducibility of macular thickness measurements with the Humphrey OCT system
    Sarah Muscat
    Tennent Institute of Ophthalmology, University of Glasgow, Glasgow, United Kingdom
    Invest Ophthalmol Vis Sci 43:490-5. 2002
    ..This demonstrates that OCT is a useful tool in the monitoring of patients with conditions that affect macular thickness, even when there is considerable degradation of the OCT signal...
  44. ncbi Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes
    Viviane Guedes
    New England Eye Center, Tufts School of Medicine, Boston, Massachusetts 02111, USA
    Ophthalmology 110:177-89. 2003
    ..There was good correspondence between findings using both the prototype and commercial OCT units. Macular and NFL thickness measurements made with OCT may have usefulness in the clinical assessment of glaucoma...
  45. ncbi Prediction of macular edema exacerbation after phacoemulsification in patients with nonproliferative diabetic retinopathy
    Hideharu Funatsu
    Department of Ophthalmology, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan
    J Cataract Refract Surg 28:1355. 2002
    ..53). CONCLUSIONS: A high VEGF level in the aqueous humor predicted a significant risk for the postoperative exacerbation of macular edema. A model was developed to predict the risk exacerbation...
  46. ncbi Serous retinal detachment and cystoid macular edema in hypotony maculopathy
    G T Kokame
    Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii 96701, USA
    Am J Ophthalmol 131:384-6. 2001
    ..To report the foveal structural findings of hypotony maculopathy imaged with optical coherence tomography...
  47. ncbi Development of macular pseudoholes: a 36-month period of follow-up
    Monica Varano
    Fondazione per l Oftalmologia G B Bietti, Rome, Italy
    Retina 22:435-42. 2002
    ..To assess the changes in visual acuity and macular sensitivity and the possible evolution into a full-thickness macular hole in patients with macular pseudoholes during a 3-year follow-up period...
  48. ncbi Macular thickness measured by optical coherence tomography (OCT) in diabetic patients
    R Lattanzio
    Department of Ophthalmology and Visual Sciences, University Hospital S. Raffaele, Milano, Italy
    Eur J Ophthalmol 12:482-7. 2002
    ..CONCLUSIONS: MT was greater in diabetics than controls and tended to increase with DR and ME severity. OCT is a sensitive technique for detecting early diabetic macular abnormalities and quantifying their reduction after laser treatment...
  49. ncbi Immunological and aetiological aspects of macular degeneration
    P L Penfold
    Department Clinical Ophthalmology, Save Sight Institute, University of Sydney, NSW 2006, Australia
    Prog Retin Eye Res 20:385-414. 2001
    ....
  50. ncbi Macular thickness measurements in healthy subjects with different axial lengths using optical coherence tomography
    Yoshikatsu Wakitani
    Department of Ophthalmology, Mie University School of Medicine, Tsu Mie, Japan
    Retina 23:177-82. 2003
    ..35, P = 0.38, and P = 0.14). CONCLUSION: When eyes with pathologic myopia were excluded, the axial length of the eye was found not to influence the average retinal thickness in the macular area...
  51. ncbi Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane
    Paul Hahn
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Ophthalmol 121:1099-105. 2003
    ..To investigate whether iron is involved in the pathogenesis of age-related macular degeneration (AMD)...
  52. ncbi Macular infarction after intravitreal amikacin: mounting evidence against amikacin
    G Galloway
    Br J Ophthalmol 86:359-60. 2002
  53. ncbi Role of OCT in the diagnosis and follow up of diabetic macular edema
    Giacomo Panozzo
    TECLO SRL, Vitreoretinal Service, Verona, Italy
    Semin Ophthalmol 18:74-81. 2003
    ..We think that this tool should always be used in monitoring the effect of therapies in future studies...
  54. ncbi Topography of diabetic macular edema with optical coherence tomography
    M R Hee
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, USA
    Ophthalmology 105:360-70. 1998
    ..The topographic mapping protocol provided geographic information on macular thickness that was intuitive and objective...
  55. ncbi A method of drusen measurement based on reconstruction of fundus background reflectance
    R T Smith
    Harkness Eye Institute, Columbia University College of Pysicians and Surgeons, New York, NY 10032, USA
    Br J Ophthalmol 89:87-91. 2005
    ..Current manual methods of drusen segmentation and quantification are laborious and subjective. The authors introduced a digital method and tested it for accuracy and reliability...
  56. ncbi Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography
    Michael S Ip
    Department of Ophthalmology, University of Wisconsin, Clinical Science Center, F4 336, 600 Highland Ave, Madison, WI 53792, USA
    Arch Ophthalmol 120:29-35. 2002
    ....
  57. ncbi Diagnosis of macular pseudoholes and lamellar macular holes by optical coherence tomography
    Belkacem Haouchine
    Department of Ophthalmology, , , Universit, Paris, France
    Am J Ophthalmol 138:732-9. 2004
    ..CONCLUSIONS: Optical coherence tomography is very useful in distinguishing MPH attributable to epiretinal membrane contraction from LMH because of partial opening of a macular cyst...
  58. ncbi Intravitreal triamcinolone for the treatment of refractory diabetic macular oedema with hard exudates: an optical coherence tomography study
    A P Ciardella
    Director of Ophthalmology, Denver Health Medical Center, 777 Bannock Street, Mail Code 0156, Denver, CO 80204, USA
    Br J Ophthalmol 88:1131-6. 2004
    ..To investigate the use of intravitreal triamcinolone acetonide (IVTA) for the treatment of diabetic macular oedema (DMO) unresponsive to previous laser photocoagulation...
  59. ncbi Intravitreal triamcinolone acetonide for diabetic diffuse macular edema: preliminary results of a prospective controlled trial
    Pascale Massin
    Department of Ophthalmology, , , , Paris, France
    Ophthalmology 111:218-24; discussion 224-5. 2004
    ..CONCLUSION: Intravitreal injection of triamcinolone effectively reduces macular thickening due to diffuse diabetic macular edema, at least in the short term. Further studies are required to demonstrate that it provides visual benefit...
  60. ncbi Comparison of the clinical diagnosis of diabetic macular edema with diagnosis by optical coherence tomography
    David J Browning
    Charlotte Eye, Ear, Nose, and Throat Associates, 6035 Fairview Road, Charlotte, NC 28210, USA
    Ophthalmology 111:712-5. 2004
    ..To compare the diagnosis of diabetic macular edema (DME) by stereoscopic slit-lamp biomicroscopic examination of the fundus with a 78-diopter noncontact lens with diagnosis by optical coherence tomography (OCT)...
  61. ncbi Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE)
    Dror Sharon
    Ocular Molecular Genetics Institute, Massachusetts Eye and Ear Infirmary, and Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 99:315-20. 2002
    ..We expect that these libraries will serve as a resource for understanding the relative expression levels of genes in the retina and the RPE and for identifying additional disease genes...
  62. ncbi Accidental Nd:YAG laser-induced choroidal neovascularization
    Howard S Ying
    The Wilmer Eye Institute at The Johns Hopkins School of Medicine, 600 North Wolfe Street, Maumenee 721, Baltimore, Maryland 21287 9277, USA
    Lasers Surg Med 40:240-2. 2008
    ..There are few reports in the literature to describe the natural history of an occupational Nd:YAG laser-induced retinal injury...
  63. ncbi Macular exudative retinal detachment in a patient with a dural cavernous sinus fistula
    Sunir J Garg
    The Retina Service Wills Eye Hospital, Philadelphia, PA 19107, USA
    Arch Ophthalmol 124:1201-2. 2006
  64. ncbi Topographic angiography and optical coherence tomography: a correlation of imaging characteristics
    C Ahlers
    University Eye Hospital Vienna, Vienna, Austria
    Eur J Ophthalmol 15:774-81. 2005
    ..Both modalities may provide further valuable insight into ARMD pathogenesis, enhance diagnostic quality, and improve the assessment of therapeutic effects...
  65. ncbi [Complex diagnosis of the early macular changes due to AMD]
    Sława Kwiecien
    Katedry i Kliniki Okulistyki II Wydziału Lekaskiego Akademii Medycznej w Warszawie
    Klin Oczna 109:209-13. 2007
    ....
  66. ncbi Identification of lesion components that influence visual function in age related macular degeneration
    R Hogg
    Queen's University Belfast, UK
    Br J Ophthalmol 87:609-14. 2003
    ..Both colour photography and angiography yielded information, which together explained considerably more of the variation in the clinical measures of vision than either on its own...
  67. ncbi Re: bilateral macular lesions in a 10-year-old girl
    Hoi Fan
    Am J Ophthalmol 144:334; author reply 334-5. 2007
  68. ncbi Optical coherence tomography fast versus regular macular thickness mapping in diabetic retinopathy
    Lala Ceklic
    Department of Ophthalmology, Clinical Center of Eastern Sarajevo, RS Bosnia and Herzegovina University of Sarajevo, Sarajevo, RS Bosnia
    Ophthalmic Res 40:235-40. 2008
    ....
  69. ncbi Optical coherence tomography findings in stage 4A retinopathy of prematurity: a theory for visual variability
    Mandar M Joshi
    Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan, USA
    Ophthalmology 113:657-60. 2006
    ..CONCLUSIONS: Anatomic macular abnormalities--not immediately apparent ophthalmoscopically--may explain the variability in visual outcome after lens-sparing vitrectomy for stage 4A ROP...
  70. ncbi Prophylactic treatment of age-related macular degeneration report number 1: 810-nanometer laser to eyes with drusen. Unilaterally eligible patients
    Thomas R Friberg
    Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 113:622.e1. 2006
    ..We advise against using prophylactic subthreshold diode laser treatment in these eyes...
  71. ncbi Massive macular hard exudates associated with branch retinal vein occlusion
    Kyoichi Takahashi
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan
    Jpn J Ophthalmol 49:527-9. 2005
    ..To report four cases of branch retinal vein occlusion (BRVO) with the complication of serous retinal detachment (SRD)...
  72. ncbi Early optical coherence tomography changes after photodynamic therapy in patients with age-related macular degeneration
    Hakan Ozdemir
    Istanbul Retina Institute Inc, Hakki Yeten Caddesi No. 8, K.7, 34349 Sisli-Istanbul, Turkey
    Am J Ophthalmol 141:574-6. 2006
    ..CONCLUSIONS: Serial OCT evaluation of patients with subfoveal CNV attributable to AMD suggests that the initial response after PDT is an increase in SF and IF...
  73. ncbi Case of POEMS syndrome associated with bilateral macular detachment resolved by autologous peripheral blood stem cell transplantation
    Kyoko Okada
    Jpn J Ophthalmol 51:237-8. 2007
  74. ncbi Limited macular translocation for subfoveal choroidal neovascularization in age-related macular degeneration
    Andrew A Chang
    Sydney Retina, Sydney, New South Wales, Australia
    Clin Experiment Ophthalmol 31:103-9. 2003
    ..To examine the safety and efficacy of limited macular translocation followed by laser photocoagulation in the management of subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD)...
  75. ncbi Unusual ocular complications of the HELLP syndrome: persistent macular elevation and localized tractional retinal detachment
    Muhittin Taskapili
    Eye Clinic, Vakif Gureba Training and Research Hospital, Istanbul, Turkey
    Ann Ophthalmol (Skokie) 39:261-3. 2007
    ..Macular elevation did not resolve; therefore, in the right eye intravitreal triamcinolone acetonide injection was performed...
  76. ncbi Optical coherence tomography in optic pit maculopathy
    Serra Arf Karacorlu
    Istanbul Retina Institute Inc, UNIMED Center, Hakki Yeten Cad, No 8 7, Sisli, Istanbul 34349, Turkey
    Int Ophthalmol 27:293-7. 2007
    ..To report the optical coherence tomography (OCT) findings in patients with optic pit maculopathy...
  77. ncbi Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 145:169-175. 2008
    ..To correlate macular thickness determined by optical coherence tomography (OCT) with light increment sensitivity and visual acuity in patients with type 2 idiopathic macular telangiectasia (IMT)...
  78. ncbi The status of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes: a survey from Beixinjing District of Shanghai city in China
    Ning Wang
    Department of Ophthalmology, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, China
    Ophthalmologica 222:32-6. 2008
    ..The images of OCT in DME included 3 types. Best-corrected visual acuity moderately correlated with retinal thickness. The macular thickness correlated with the severity of DR but not with posterior vitreous detachment...
  79. ncbi Intravitreal bevacizumab (Avastin) for the treatment of choroidal neovascularization in age-related macular degeneration: results from 118 cases
    K C Madhusudhana
    Southampton Eye Unit, Tremona Road, Southampton S016 6YD, UK
    Br J Ophthalmol 91:1716-7. 2007
  80. ncbi Peripapillary serous retinal detachment preceding complete posterior vitreous detachment
    Cengiz Aras
    Department of Ophthalmology, Cerrahpasa Medical School of Istanbul University, 4 Kisim T O 94 Blok D1 Ataköy, Istanbul 34753 01, Turkey
    Graefes Arch Clin Exp Ophthalmol 246:927-9. 2008
    ..To report on a case of peripapillary serous detachment due to vitreopapillary traction during the development of posterior vitreous detachment...
  81. ncbi A randomized, placebo-controlled clinical trial of intravitreal triamcinolone for refractory diabetic macular edema
    Mohammad H Dehghan
    Ophthalmic Research Centre of Shaheed Beheshti Medical University, Labbafinejad Medical Centre, Pasdaran Ave Boostan 9 St, Tehran, 16666, Iran
    Int Ophthalmol 28:7-17. 2008
    ..To evaluate the effect of intravitreal triamcinolone acetonide (IVT) on refractory diabetic macular edema (DME)...
  82. ncbi Longitudinal cohort study of patients with birdshot chorioretinopathy. III. Macular imaging at baseline
    Dominique Monnet
    Le Service d Ophtalmologie, Hôpital Cochin and Université Paris Descartes, Faculte de Medecine, Paris, France
    Am J Ophthalmol 144:818-828. 2007
    ....
  83. ncbi Macular translocation with 360 degrees retinotomy for exudative age-related macular degeneration
    Sabine Aisenbrey
    Department I, University Eye Clinic Tuebingen, Schleichstrasse 12-16, 72076 Tuebingen, Germany
    Arch Ophthalmol 120:451-9. 2002
    ..Although the procedure has a high rate of surgical and postoperative complications, the functional and anatomical results appear to be promising for selected patients with subfoveal CNV secondary to AMD...
  84. ncbi Sheathotomy in complicated cases of branch retinal vein occlusion
    Sven Crafoord
    Department of Ophthalmology, Orebro University Hospital, Orebro, Sweden
    Acta Ophthalmol 86:146-50. 2008
    ..To report the clinical experience and results of using a microsurgical technique to decompress the arteriovenous connection in complicated branch retinal vein occlusion (BRVO) combined with haemorrhage, oedema and ischaemia...
  85. ncbi Spontaneous separation in idiopathic vitreomacular traction syndrome associated with contralateral full-thickness macular hole
    A Rodriguez
    Servicio Retina y Vítreo, Fundacion Oftalmologica Nacional, Facultad de Medicina, Universidad del Rosario, Bogota, Colombia
    Eur J Ophthalmol 16:733-40. 2006
    ..An association to a full-thickness macular hole was observed in the contralateral eye of one of the patients...
  86. ncbi Full macular translocation versus photodynamic therapy with verteporfin in the treatment of neovascular age-related macular degeneration: 1-year results of a prospective, controlled, randomised pilot trial (FMT-PDT)
    Faik Gelisken
    Centre for Ophthalmology, University of Tuebingen, Schleichstr 12, 72076 Tuebingen, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1085-95. 2007
    ..The purpose of this study was to compare full macular translocation (FMT) with photodynamic therapy (PDT) in the treatment of neovascular age-related macular degeneration (AMD)...
  87. ncbi Macular translocation with radial scleral ouffolding: experimental studies and initial human results
    J D Benner
    Delmarva Vitreoretinal Center, Salisbury, Maryland, USA
    Graefes Arch Clin Exp Ophthalmol 239:815-23. 2001
    ..CONCLUSIONS: Limited macular translocation by radial scleral outfolding can improve vision in selected patients. Radial evagination appears to be as effective as circumferential infolding...
  88. ncbi Long-term results of submacular surgery combined with macular translocation of the retinal pigment epithelium in neovascular age-related macular degeneration
    Robert E MacLaren
    Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 112:2081-7. 2005
    ..Caution should be applied when drawing firm conclusions from similar studies that provide data after only 2 years' follow-up...
  89. ncbi Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularization
    Carl H Park
    Vitreoretinal Service, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Ophthalmol 136:830-5. 2003
    ..MTS360 appears to be effective in stabilizing vision, especially in patients who had previously undergone only one OPT session. Further studies are indicated to evaluate the efficacy of MTS360 in this current era of OPT...
  90. ncbi [Results of limited macular translocation in subfoveal choroidal neovascularization in age-related macular degeneration]
    D Pawlak
    Clinique Ophtalmologique Universitaire de Creteil, Hopital Intercommunal de Creteil, Service d Ophtalmologie, 40, avenue de Verdun, 94010 Creteil, France
    J Fr Ophtalmol 27:3S31-7. 2004
    ..The purpose of this study was to evaluate the visual results obtained with macular translocation (MT) in subfoveal choroidal neovascularization due to AMD...
  91. ncbi Initial experience of macular translocation in Singapore - one-year results
    K G Au Eong
    The Eye Institute, Alexandra Hospital, Singapore
    Ann Acad Med Singapore 33:641-8. 2004
    ..This paper reports the 1-year results of the first 2 cases of macular translocation in Singapore...
  92. ncbi Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degeneration
    Prithvi Mruthyunjaya
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
    Ophthalmology 111:1715-24. 2004
    ..Macular translocation with 360 degrees retinectomy is an effective treatment option for patients with vision loss in their second eye resulting from neovascular AMD...
  93. ncbi Unsuccessful vitrectomy without gas tamponade for macular retinal detachment and retinoschisis without optic disc pit
    Kazuki Hotta
    Department of Ophthalmology, Kameda Medical Center, Chiba, Japan
    Ophthalmic Surg Lasers Imaging 35:328-31. 2004
    ..Vitreous traction may not have played a major role in introducing fluid into the submacular space in this case. Gas tamponade may be indispensable to achieve surgical success. This may also pertain to some cases of optic nerve pits...
  94. ncbi Foveal sensitivity and fixation stability before and after macular translocation with 360-degree retinotomy
    Tomohito Oyagi
    Department of Ophthalmology, Osaka Rosai Hospital, Osaka University Medical School, Japan
    Retina 24:548-55. 2004
    ....
  95. ncbi Treatment of submacular hemorrhage with low-dose intravitreal tissue plasminogen activator injection and pneumatic displacement
    B A Handwerger
    Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, USA
    Arch Ophthalmol 119:28-32. 2001
    ..Final visual acuity was limited by the underlying presence of end-stage ARMD...
  96. ncbi Retinal vasculitis and cystoid macular edema after body tattooing: a case report
    M M Moschos
    Jules Gonin Eye Hospital, Lausanne University Hospital, Lausanne, Switzerland
    Klin Monatsbl Augenheilkd 221:424-6. 2004
    ..A phagocytosis of tattoo pigments leading to their lysis is described in the literature as a mechanism causing vasculitis...
  97. ncbi Treatment of central retinal vein occlusion with triamcinolone acetonide: an optical coherence tomography study
    Michael Ip
    Department of Ophthalmology and Visual Science, University of Wisconsin, Clinical Science Center, Madison, WI 53792, USA
    Semin Ophthalmol 18:67-73. 2003
    ..Optical coherence tomography demonstrated significant anatomic improvement in the majority of patients with macular edema due to CRVO treated with intravitreal injection of triamcinolone acetonide...
  98. ncbi [Optical coherence tomography in the diagnosis and follow-up of patients with uveitic macular edema]
    E K Reinthal
    Abteilung I, Universitatsaugenklinik, Tubingen
    Ophthalmologe 101:1181-8. 2004
    ..Knowledge about the efficacy of OCT in the diagnosis and follow-up of macular edema in uveitis patients is still limited...
  99. ncbi Limited macular translocation compared with photodynamic therapy in the management of subfoveal choroidal neovascularization in age-related macular degeneration
    Dominique Pawlak
    University Eye Clinic of Creteil, Intercommunal and Henri Mondor Assistance Publique des Hôpitaux de Paris Hospitals, University of Paris XII, 40 avenue de Verdun, 94010 Creteil, France
    Am J Ophthalmol 137:880-7. 2004
    ..To compare the visual outcome of macular translocation (MT) versus photodynamic therapy (PDT) for subfoveal predominantly classic neovascularization in age-related macular degeneration (AMD)...
  100. ncbi [Macular translocation with 360 degree retinotomy in the treatment if exudative macular degeneration. Functional and angiographic results]
    S Aisenbrey
    Zentrum für Augenheilkunde, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Ophthalmologe 99:164-70. 2002
    ..Subsequent translocation of the foveal neural retina to adjacent healthy RPE should result in stabilization and possibly improvement of visual acuity...
  101. ncbi Is membrane extraction in cases of exudative age-related macular degeneration still up-to-date? A 4-year résumé
    Jorg C Schmidt
    Zentrum für Augenheilkunde, Philipps Universitat Marburg, Marburg, Deutschland
    Ophthalmologica 217:401-7. 2003
    ..Parafoveal laser coagulation can be applied, and in cases of subfoveal location a pars plana vitrectomy with subretinal resection of the CNV is possible...

Research Grants145 found, 100 shown here

  1. Absolute Fundus Autofluorescence in Retinal Degenerations
    ROLAND THEODORE SMITH; Fiscal Year: 2010
    ....
  2. Biomedical Image Engineering of Macular Images
    R Smith; Fiscal Year: 2007
    ..These advances would extend profound health and social benefits to our aging population. ..
  3. Biomedical Image Engineering of Macular Images
    ROLAND SMITH; Fiscal Year: 2009
    ..These advances would extend profound health and social benefits to our aging population. ..
  4. Central Scotomas in AMD and Cortical Remapping
    Janet Sunness; Fiscal Year: 2005
    ....
  5. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2006
    ..abstract_text> ..
  6. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2007
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  7. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2009
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  8. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2010
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  9. Early Retinal Disease Detection Using Standard And Novel Retinal Imaging Techniqu
    DEAN VANNASDALE; Fiscal Year: 2007
    ..This will lead to improved treatments that minimize vision loss in affected individuals. ..
  10. Perceptual encoding and imagery in prosopagnosia
    Jason Barton; Fiscal Year: 2007
    ..From our prior work, we hypothesize that covert or unconscious recognition is the residual product of a partially damaged face network in the brain. We propose a functional imaging experiment to test this hypothesis. ..
  11. RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS
    Werner Gellermann; Fiscal Year: 2002
    ..Furthermore, we propose a series of clinical studies in humans to validate its function and to begin to establish its role as a possible screening test for AMD. PROPOSED COMMERCIAL APPLICATION: Screening of macular pigment levels. ..
  12. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
    ..The proposed studies will provide needed data on relationships among AMD, lipofuscin and macular pigment, estimate genetic contribution to the latter, and assist identification of individuals at greatest risk for vision loss. ..
  13. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  14. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  15. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2007
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  16. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  17. NONINVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 1993
    ..Determine whether atrophic regions are bounded by regions of elevated lipofuscin, and whether extreme levels of lipofuscin identify retinal regions at risk for subsequent atrophy and/or neovascularization...
  18. SPATIAL EXTENT OF RETINAL DAMAGE
    Ann E Elsner; Fiscal Year: 2010
    ..We will test whether the damage can be modeled as the early occurrence of an inflammatory response that differs among individuals and who could benefit from personalized treatment. ..
  19. Ophthalmic Imaging Using Adaptive Optics and OCT
    John Werner; Fiscal Year: 2009
    ..These advanced imaging techniques will be deployed for evaluating the changes in the retina and optic nerve resulting from novel therapies for rescuing retinal layers from the leading causes of blindness. ..
  20. RETINAL PATHOPHYSIOLOGY OF INFANTS AND ADULTS
    David Birch; Fiscal Year: 2005
    ..In the mouse models, cone measures will necessarily focus on the b-wave, using monochromatic stimuli, long-duration flashes, and flicker to optimize isolation of cone from rod responses. ..
  21. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  22. OCULAR MELANOMA
    Judy Kim; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  23. STUDY AND TREATMENT OF RETINOPATHY ASSOCIATED WITH AIDS
    William Freeman; Fiscal Year: 1993
    ....
  24. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2009
    ..If we can determine the cause of the elevated pressure, then we may be able to develop a more effective pressure-lowering treatment or cure for this debilitating disease. ..
  25. Studies of Retinopathy of AIDS in the HAART Era
    William Freeman; Fiscal Year: 2004
    ..This will allow development of a low cost injectable drug delivery system that will allow treatment of resistant retinitis at intervals of every 3 months or longer without the added cost and risk of surgery in the operating room. ..
  26. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    Thomas Gardner; Fiscal Year: 2002
    ..This combination of molecular and functional analyses will provide new insights into the pathogenesis of vascular permeability in diabetes and other retinopathies. ..
  27. Cholesterol Crystalline Domain Function in Eye Lens: EPR Spin-Labeling Studies
    Witold K Subczynski; Fiscal Year: 2010
    ....
  28. SPATIAL EXTENT OF RETINAL DAMAGE
    ANN ELSNER; Fiscal Year: 2001
    ..These studies should provide tests for risk factors and noninvasive early detection, as well as possibly providing a better classification scheme and more accurate prognostic tests for patients with ARM/AMD. ..
  29. RETINAL PATHOPHYSIOLOGY OF INFANTS AND ADULTS
    David Birch; Fiscal Year: 2000
    ..We will determine whether modifying the lipid environment of the outer segment has an effect on the severity of degeneration in these animal models of RP where the disease-causing mutation affects outer segment structure. ..
  30. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    Thomas Gardner; Fiscal Year: 2004
    ..abstract_text> ..
  31. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  32. Low-Cost Device for Digital Retinal Imaging
    Ann E Elsner; Fiscal Year: 2010
    ..While this project focuses on diabetic retinopathy in humans, future applications include other retinal disorders in both humans and animal models. ..
  33. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  34. Low-Cost Device for Digital Retinal Imaging
    ANN ELSNER; Fiscal Year: 2007
    ..We will investigate the key features considered necessary for early detection grading, and also more the serious damage that is typically discovered late in the rural and urban underserved. ..
  35. Lipid Rafts in Eye Lens: Discrimination by Pulse EPR
    WITOLD SUBCZYNSKI; Fiscal Year: 2009
    ..Age-related nuclear cataract is a primary cause of blindness in the elderly in third world countries. ..