macula lutea

Summary

Summary: An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)

Top Publications

  1. ncbi Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study
    Won Kyung Song
    Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
    Invest Ophthalmol Vis Sci 51:3913-8. 2010
  2. pmc Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass 02111 1533, USA
    Arch Ophthalmol 124:193-8. 2006
  3. pmc Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging
    Suhail Alam
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California 95817, USA
    Ophthalmology 113:1425-31. 2006
  4. pmc Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
  5. ncbi Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
  6. ncbi Triple therapy of vitrectomy, intravitreal triamcinolone, and macular laser photocoagulation for intractable diabetic macular edema
    Se Woong Kang
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Am J Ophthalmol 144:878-885. 2007
  7. ncbi Long-term follow-up of vitrectomy for diffuse nontractional diabetic macular edema
    Kazuyuki Kumagai
    Shinjo Ophthalmologic Institute, Miyazaki, Japan
    Retina 29:464-72. 2009
  8. pmc Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema
    M A Ibrahim
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Eye (Lond) 26:454-62. 2012
  9. ncbi Optical coherence tomography evaluation of detached macula from rhegmatogenous retinal detachment and central serous chorioretinopathy
    Sun Young Lee
    Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong, Songpa Gu, Seoul, Korea
    Am J Ophthalmol 145:1071-1076. 2008
  10. ncbi Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane
    Paul Hahn
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Ophthalmol 121:1099-105. 2003

Research Grants

  1. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2013
  2. Developing Small Molecules to Potentiate RNA Interference
    Peng Jin; Fiscal Year: 2010
  3. Central Scotomas in AMD and Cortical Remapping
    Janet Sunness; Fiscal Year: 2005
  4. RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMS
    Xiangrun Huang; Fiscal Year: 2007
  5. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
  6. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
  7. Perceptual encoding and imagery in prosopagnosia
    Jason Barton; Fiscal Year: 2008
  8. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
  9. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
  10. RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS
    Werner Gellermann; Fiscal Year: 2002

Detail Information

Publications272 found, 100 shown here

  1. ncbi Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study
    Won Kyung Song
    Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
    Invest Ophthalmol Vis Sci 51:3913-8. 2010
    ..To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT)...
  2. pmc Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass 02111 1533, USA
    Arch Ophthalmol 124:193-8. 2006
    ..To report normal macular thickness measurements in healthy eyes using the latest commercially available optical coherence tomography (OCT) mapping software, version 3.0, from the Stratus OCT (OCT3)...
  3. pmc Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging
    Suhail Alam
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California 95817, USA
    Ophthalmology 113:1425-31. 2006
    ..To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology...
  4. pmc Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
    ..A2, Carl Zeiss Meditec Inc., Dublin, CA) was investigated. The nerve fiber layer (NFL) thickness, macula thickness map, and optic nerve head (ONH) parameters in normal eyes were studied...
  5. ncbi Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  6. ncbi Triple therapy of vitrectomy, intravitreal triamcinolone, and macular laser photocoagulation for intractable diabetic macular edema
    Se Woong Kang
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Am J Ophthalmol 144:878-885. 2007
    ..To evaluate the effect of a sequentially combined triple therapy on intractable diabetic macular edema (DME)...
  7. ncbi Long-term follow-up of vitrectomy for diffuse nontractional diabetic macular edema
    Kazuyuki Kumagai
    Shinjo Ophthalmologic Institute, Miyazaki, Japan
    Retina 29:464-72. 2009
    ..To report the long-term results of pars plana vitrectomy for diffuse nontractional diabetic macular edema...
  8. pmc Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema
    M A Ibrahim
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Eye (Lond) 26:454-62. 2012
    ..To report macular thickness values in normal eyes and eyes with diabetic macular edema (DME) using time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT), and to derive a conversion equation...
  9. ncbi Optical coherence tomography evaluation of detached macula from rhegmatogenous retinal detachment and central serous chorioretinopathy
    Sun Young Lee
    Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong, Songpa Gu, Seoul, Korea
    Am J Ophthalmol 145:1071-1076. 2008
    ..To compare structural changes using optical coherence tomography (OCT) and visual acuity (VA) loss in patients with shallow macula-off rhegmatogenous retinal detachment (RD) and central serous chorioretinopathy (CSC) involving the macula...
  10. ncbi Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane
    Paul Hahn
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Ophthalmol 121:1099-105. 2003
    ..To investigate whether iron is involved in the pathogenesis of age-related macular degeneration (AMD)...
  11. ncbi Diagnosis of macular pseudoholes and lamellar macular holes by optical coherence tomography
    Belkacem Haouchine
    Department of Ophthalmology, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite, Paris, France
    Am J Ophthalmol 138:732-9. 2004
    ..To assess the usefulness of optical coherence tomography (OCT) for better differential diagnosis of macular pseudoholes (MPH) and lamellar macular holes (LMH)...
  12. ncbi Comparison of macular thickness measurements between time domain and spectral domain optical coherence tomography
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
    Invest Ophthalmol Vis Sci 49:4893-7. 2008
    ..To compare macular thickness measurements obtained from time domain optical coherence tomography (OCT) and spectral domain OCT and to evaluate their repeatability and agreement...
  13. ncbi A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration
    Sarah Sabour-Pickett
    Department of Optometry, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland
    Mol Nutr Food Res 56:270-86. 2012
    ....
  14. ncbi The effect of duration of macular detachment on results after the scleral buckle repair of primary, macula-off retinal detachments
    Tarek S Hassan
    Associated Retinal Consultants, PC, The Department of Ophthalmology, William Beaumont Hospital Eye Institute, 3535 West 13 Mile Road, Royal Oak, MI 48073, USA
    Ophthalmology 109:146-52. 2002
    ..To present a current series that determined the effect of duration of macular detachment (DMD) and patient age on postscleral buckle (SB) visual acuity (VA) and anatomic results...
  15. ncbi Vitrectomy for diffuse macular edema in cases of diabetic retinopathy
    N Tachi
    Department of Ophthalmology, Aichi Medical University, Japan
    Am J Ophthalmol 122:258-60. 1996
    ..To ascertain the effects of posterior vitreous detachment for diffuse diabetic macular edema...
  16. ncbi Macular thickness interoperator and intraoperator reproducibility in healthy eyes using 7 optical coherence tomography instruments
    Luisa Pierro
    Department of Ophthalmology, University Vita Salute, Scientific Institute San Raffaele, Via Olgettina 60, Milan, Italy
    Am J Ophthalmol 150:199-204.e1. 2010
    ..To evaluate macular thickness measurement reproducibility using 6 new spectral-domain (SD) optical coherence tomography (OCT) devices and 1 time-domain OCT device..
  17. ncbi Natural history of macular status in recent-onset branch retinal vein occlusion: an optical coherence tomography study
    Daraius Shroff
    Guru Nanak Eye Centre, Maulana Azad Medical College, University of Delhi, New Delhi 110002, India
    Int Ophthalmol 28:261-8. 2008
    ..To evaluate serially the course of structural changes in the macula in recent onset branch retinal vein occlusion (BRVO), using optical coherence tomography (OCT)...
  18. pmc Comparison of optical coherence tomography models OCT1 and Stratus OCT for macular retinal thickness measurement
    V Pierre-Kahn
    Service d Ophtalmologie, Hôpital Lariboisière 2, rue Ambroise Pare, 75475 Paris Cedex 10, France
    Br J Ophthalmol 89:1581-5. 2005
    ..To compare the values measured for retinal macular thickness with the first and last generations of the optical coherence tomograph (OCT1 and Stratus OCT, Zeiss, Humphrey Division)...
  19. ncbi Associations between chronic glycosylated haemoglobin (HbA1c) level and macular volume in diabetes patients without macular oedema
    Ling Yeung
    Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan
    Acta Ophthalmol 88:753-8. 2010
    ..This study aimed to examine the correlation between glycosylated haemoglobin (HbA1c) level and macular volume in diabetes patients without diabetic macular oedema (DMO)...
  20. ncbi Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study
    Meike Trieschmann
    Institute of Ophthalmology, St Franziskus Hospital, and Institute of Epidemiology, University of Munster, Germany
    Exp Eye Res 84:718-28. 2007
    ..Further, our results suggest that saturable mechanisms play a role in the retinal capture and/or stabilisation of the macular carotenoids...
  21. ncbi [Diagnosis and follow-up of non-diabetic macular edema with optical coherence tomography (OCT)]
    A E Schneeberg
    Augenklinik, Universitat Wurzburg
    Ophthalmologe 100:960-6. 2003
    ..Objective and quantitative follow-up of macular edema with present clinical methods is limited. We studied to what extent optical coherence tomography (OCT) may be clinically useful in diagnosis and follow-up of non-diabetic macular edema...
  22. ncbi Use of optical coherence tomography (OCT) and indirect ophthalmoscopy in the diagnosis of macular edema in diabetic patients
    R O Moreira
    State Institute of Diabetes and Endocrinology (IEDE, Rio de Janeiro, RJ, Brazil
    Int Ophthalmol 24:331-6. 2001
    ..High levels of haemoglobin A1c might be associated with the presence of ME. Diabetic complications (nephropathy and neuropathy) are associated with retinopathy but not with macular edema...
  23. ncbi Relationship of macular microcirculation and retinal thickness with visual acuity in diabetic macular edema
    Kumi Sakata
    Department of Ophthalmology, Tokyo Women s Medical University, Tokyo, Japan
    Ophthalmology 114:2061-9. 2007
    ....
  24. ncbi A central dip in the macular pigment spatial profile is associated with age and smoking
    Mark L Kirby
    Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
    Invest Ophthalmol Vis Sci 51:6722-8. 2010
    ..To investigate the relationship between specific macular pigment (MP) spatial profiles and risk factors for age-related macular degeneration (AMD)...
  25. ncbi Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography
    Michael S Ip
    Department of Ophthalmology, University of Wisconsin, Clinical Science Center, F4 336, 600 Highland Ave, Madison, WI 53792, USA
    Arch Ophthalmol 120:29-35. 2002
    ....
  26. pmc Macular thickness measurements in healthy Norwegian volunteers: an optical coherence tomography study
    Alexandra Wexler
    Department of Ophthalmology, St Olavs University Hospital, Trondheim, Norway
    BMC Ophthalmol 10:13. 2010
    ..Our purpose was to collect normative macular thickness data in Norwegians and to evaluate the association between macular thickness and age, gender, parity, and contraception status...
  27. ncbi Macular and retinal nerve fiber layer thickness measurements in normal eyes with the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000
    Jingjing Huang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China Center for Advanced Eye Care, Carson City, NV, USA
    J Glaucoma 20:118-25. 2011
    ..To compare retinal nerve fiber layer (RNFL) and macular thickness measurements using time-domain optical coherence tomography (TD OCT) and 2 Fourier-domain OCTs (FD OCT)...
  28. ncbi Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy
    H Ozdemir
    Ophthalmology, The Istanbul Retina Institute Inc, UNIMED Center, Istanbul, Turkey
    Eye (Lond) 22:204-8. 2008
    ..To determine macular sensitivity and fixation characteristics in patients with unilateral resolved central serous chorioretinopathy (CSC) using fundus-related microperimetry...
  29. ncbi Focal macular electroretinogram in macular edema secondary to central retinal vein occlusion
    Ken Ogino
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 52:3514-20. 2011
    ..To evaluate the usefulness of focal macular electroretinography (fmERG) for evaluation of macular function in eyes with central retinal vein occlusion (CRVO)...
  30. ncbi Vitreous inflammatory factors and serous macular detachment in branch retinal vein occlusion
    Hidetaka Noma
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Owada shinden, Yachiyo, Chiba, Japan
    Retina 32:86-91. 2012
    ....
  31. ncbi The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Am J Clin Nutr 87:1521-9. 2008
    ..Lutein and docosahexaenoic acid (DHA) may protect against age-related macular degeneration (AMD). Lutein is a component of macular pigment. DHA is in the retina...
  32. ncbi Quality issues in interpretation of optical coherence tomograms in macular diseases
    Amitha Domalpally
    Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
    Retina 29:775-81. 2009
    ..To analyze the scan characteristics associated with poor-quality Stratus optical coherence tomograms submitted to a reading center for multicenter clinical trials...
  33. ncbi Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study
    Christopher K S Leung
    Department of Ophthalmology, Caritas Medical Centre, Hong Kong, China
    Ophthalmology 112:391-400. 2005
    ....
  34. ncbi Diabetic macular oedema and visual loss: relationship to location, severity and duration
    Thomas W Gardner
    Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Acta Ophthalmol 87:709-13. 2009
    ..To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening...
  35. ncbi Macular hole formation: new data provided by optical coherence tomography
    A Gaudric
    Department of Ophthalmology, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite Paris 7, France
    Arch Ophthalmol 117:744-51. 1999
    ..To establish the sequence of events leading from vitreofoveal traction to full-thickness macular hole formation...
  36. ncbi Spectral-domain optical coherence tomography imaging of the detached macula in rhegmatogenous retinal detachment
    Hideo Nakanishi
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Shougoin, Sakyo ku, Kyoto, Japan
    Retina 29:232-42. 2009
    ..To assess detached macula in rhegmatogenous retinal detachment by using spectral-domain optical coherence tomography...
  37. ncbi Evaluation of macular changes before and after successful retinal detachment surgery using stratus-optical coherence tomography
    Amelie Lecleire-Collet
    Department of Ophthalmology, Rouen University Hospital Charles Nicolle, Rouen, France
    Am J Ophthalmol 142:176-9. 2006
    ..To assess preoperative and postoperative infra-clinical macular changes in macula-off retinal detachment (RD) using third-generation optical coherence tomography (OCT3)...
  38. ncbi Macular recovery after retinal detachment
    Hana Abouzeid
    Department of Vitreretinal Surgery, Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland
    Acta Ophthalmol Scand 84:597-605. 2006
    ..However, new therapeutic options such as exposure to hyperoxia or different growth factors may help to improve the final visual outcome in the presence of an already detached macula...
  39. ncbi Role of intravitreal bevacizumab in adult onset Coats' disease
    Neha Goel
    Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India
    Int Ophthalmol 31:183-90. 2011
    ..Intravitreal bevacizumab was well tolerated by our patients, and no adverse effects were observed...
  40. ncbi Enhanced depth imaging optical coherence tomography of the sclera in dome-shaped macula
    Yutaka Imamura
    The LuEster T Mertz Retinal Research Center, Manhattan Eye Ear and Throat Hospital, New York, New York, USA
    Am J Ophthalmol 151:297-302. 2011
    ..To examine the posterior anatomic structure of eyes with dome-shaped macula using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT)...
  41. ncbi Intravitreal bevacizumab (avastin) in the treatment of macular edema associated with perfused retinal vein occlusion
    Kuo Hsuan Hung
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Ocul Pharmacol Ther 26:85-90. 2010
    ..To evaluate the efficacy and safety of intravitreal bevacizumab (Avastin) injection in patients with macular edema (ME) secondary to retinal vein occlusive diseases...
  42. ncbi How effective is macula-off retinal detachment surgery. Might good outcome be predicted?
    E Doyle
    St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Eye (Lond) 21:534-40. 2007
    ..To determine factors associated with anatomical and functional outcomes of macula-off retinal detachment surgery in a modern vitreoretinal unit...
  43. ncbi Long-term follow-up with optical coherence tomography and microperimetry in eyes with metamorphopsia after macula-off retinal detachment repair
    A Rossetti
    Department of Ophthalmology, University of Padua, Padua, Italy
    Eye (Lond) 24:1808-13. 2010
    ..to report the long-term sequential morphological and functional results in eyes with metamorphopsia after retinal detachment (RD) repair...
  44. ncbi The multifocal electroretinogram in acute macular neuroretinopathy
    Andrew C Browning
    Department of Ophthalmology and Visual Sciences, Eye, Ear, Nose and Throat Unit, University Hospital, Queen s Medical Center, Nottingham, England
    Arch Ophthalmol 121:1506-7. 2003
  45. pmc Structural and functional assessment of the macular region in patients with glaucoma
    F N Kanadani
    Department of Psychology, Columbia University, 405 Schermerhorn, New York, NY 10027, USA
    Br J Ophthalmol 90:1393-7. 2006
    ....
  46. ncbi Macular thickness measurements in normal eyes using spectral domain optical coherence tomography
    John E Legarreta
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmic Surg Lasers Imaging 39:S43-9. 2008
    ..The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT)...
  47. ncbi Measurement of retinal nerve fiber layer thickness and macular volume for glaucoma detection using optical coherence tomography
    Tomonari Ojima
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Jpn J Ophthalmol 51:197-203. 2007
    ..To evaluate retinal nerve fiber layer (RNFL) thickness and macular volume in normal eyes and in the eyes of patients with glaucoma, and to compare the usefulness of these measurements in diagnosing glaucomatous eyes...
  48. ncbi Assessment of macular retinal thickness and volume in normal eyes and highly myopic eyes with third-generation optical coherence tomography
    P C Wu
    Department of Ophthalmology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Eye (Lond) 22:551-5. 2008
    ..To compare the macular retinal thickness and macular volume between subjects with high myopia and non-myopia...
  49. ncbi The variation in optical coherence tomography-measured macular thickness in diabetic eyes without clinical macular edema
    David J Browning
    Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, North Carolina, USA
    Am J Ophthalmol 145:889-93. 2008
    ..To determine the variation in optical coherence tomography (OCT)-measured macular thickness in diabetic eyes without clinical edema and to investigate factors that might influence variation in macular thickness...
  50. pmc Evaluation of changes of macular thickness in diabetic retinopathy after cataract surgery
    Soon Il Kwon
    Department of Ophthalmology, Hallym University Sacred Heart Hospital, 896 Pyeongchon dong, Anyang, Korea
    Korean J Ophthalmol 25:238-42. 2011
    ..To assess the macular thickness changes after cataract surgery in diabetic patients using optical coherence tomography (OCT)...
  51. ncbi The macular thickness and volume in glaucoma: an analysis in normal and glaucomatous eyes using OCT
    A Giovannini
    Institute of Ophthalmology, University, Ancona, Italy
    Acta Ophthalmol Scand Suppl 236:34-6. 2002
    ..To evaluate macular volume in normal and glaucomatous eyes using Optical Coherence Tomography (OCT)...
  52. ncbi Macular thickness evaluation using the optical coherence tomography in normal Indian eyes
    Hem K Tewari
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Indian J Ophthalmol 52:199-204. 2004
    ..To determine the normative values for macular thickness and volume by Optical Coherence Tomography (OCT 3) in healthy Indian subjects...
  53. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
    ..This may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve, in secondary progressive MS and primary progressive MS...
  54. ncbi The change of macular thickness measured by optical coherence tomography in relation to glycemic control in diabetic patients
    Sang Woong Moon
    Department of Ophthalmology, Kyung Hee University College of Medicine, Seoul, South Korea
    Graefes Arch Clin Exp Ophthalmol 249:839-48. 2011
    ..To demonstrate the change in macular thickness using optical coherence tomography in diabetic patients and to assess its relationship with glycosylated hemoglobin (HbA1c) levels...
  55. ncbi Diagnostic capability of macular parameters of Stratus OCT 3 in detection of early glaucoma
    R S Parikh
    Bombay City Eye Institute and Research Center, 5 Victor Villa, Babulnath Road, Mumbai 400107, India
    Br J Ophthalmol 94:197-201. 2010
    ..To report the diagnostic capability of Stratus OCT macular parameters in early glaucoma...
  56. ncbi Macular microcirculation and macular oedema in branch retinal vein occlusion
    H Noma
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Yachiyo, Chiba 276 8524, Japan
    Br J Ophthalmol 93:630-3. 2009
    ..The relationship between the blood-flow velocity in the perifoveal capillaries and macular oedema was investigated in patients with branch retinal vein occlusion (BRVO)...
  57. ncbi Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography
    David S Greenfield
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, 7108 Fairway Dr, Suite 340, Palm Beach Gardens, FL 33418, USA
    Arch Ophthalmol 121:41-6. 2003
    ..To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography...
  58. ncbi Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane
    Simone S van Soest
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences KNAW, Meibergdreef, Amsterdam, The Netherlands
    Mol Vis 13:1608-17. 2007
    ..To describe gene expression differences between healthy, young human retinal pigment epithelium (RPE) cells from the macular area and RPE cells from two locations in the retinal periphery...
  59. ncbi Comparison of the clinical diagnosis of diabetic macular edema with diagnosis by optical coherence tomography
    David J Browning
    Charlotte Eye, Ear, Nose, and Throat Associates, 6035 Fairview Road, Charlotte, NC 28210, USA
    Ophthalmology 111:712-5. 2004
    ..To compare the diagnosis of diabetic macular edema (DME) by stereoscopic slit-lamp biomicroscopic examination of the fundus with a 78-diopter noncontact lens with diagnosis by optical coherence tomography (OCT)...
  60. pmc Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE)
    Dror Sharon
    Ocular Molecular Genetics Institute, Massachusetts Eye and Ear Infirmary, and Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 99:315-20. 2002
    ..We expect that these libraries will serve as a resource for understanding the relative expression levels of genes in the retina and the RPE and for identifying additional disease genes...
  61. ncbi Comparison of three different optical coherence tomography models for total macular thickness measurements in healthy controls
    Marcel N Menke
    Department of Ophthalmology, University of Zurich, Frauenklinikstrasse 24 CH 8091 Zürich, Switzerland
    Ophthalmologica 223:352-6. 2009
    ..The purpose of this study was to compare 3 commercially available OCT models for retinal thickness measurements in healthy controls...
  62. ncbi Optical coherence tomography findings in photic maculopathy
    Sheau Jiun Huang
    LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA
    Retina 23:863-6. 2003
  63. ncbi Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography
    Felipe A Medeiros
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California 92093 0946, USA
    Am J Ophthalmol 139:44-55. 2005
    ..To compare the ability of optical coherence tomography retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to differentiate between healthy eyes and eyes with glaucomatous visual field loss...
  64. pmc High-speed, ultra-high-resolution optical coherence tomography of acute macular neuroretinopathy
    B K Monson
    Br J Ophthalmol 91:119-20. 2007
  65. pmc A method of drusen measurement based on the geometry of fundus reflectance
    R Theodore Smith
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Biomed Eng Online 2:10. 2003
    ..Current manual methods of drusen measurement are laborious and subjective. Our purpose was to expedite clinical research with an accurate, reliable digital method...
  66. ncbi Dome-shaped macula in eyes with myopic posterior staphyloma
    David Gaucher
    Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Service d Ophtalmologie, Universite Paris 7, Paris, France
    Am J Ophthalmol 145:909-14. 2008
    ..To describe an unusual feature in myopic eyes responsible for visual loss, which we call a dome-shaped macula...
  67. pmc A method of drusen measurement based on reconstruction of fundus background reflectance
    R T Smith
    Harkness Eye Institute, Columbia University College of Pysicians and Surgeons, New York, NY 10032, USA
    Br J Ophthalmol 89:87-91. 2005
    ..Current manual methods of drusen segmentation and quantification are laborious and subjective. The authors introduced a digital method and tested it for accuracy and reliability...
  68. ncbi Optical coherence tomographic evaluation of macular infarction following dapsone overdose
    Nazimul Hussain
    Smt Kanuri Santhamma Retina Vitreous Centre, L V Prasad Eye Institute, Hyderabad, India
    Indian J Ophthalmol 54:271-2. 2006
    ..Hence, OCT could show the progression of foveal atrophy from cystic macular edema following dapsone poisoning...
  69. ncbi Classifying and grading retinal signs in severe malaria
    S P Harding
    St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Trop Doct 36:1-13. 2006
  70. pmc Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes
    Viviane Guedes
    New England Eye Center, Tufts School of Medicine, Boston, Massachusetts 02111, USA
    Ophthalmology 110:177-89. 2003
    ..To evaluate the hypothesis that macular thickness correlates with the diagnosis of glaucoma...
  71. ncbi Macular thickness measurements in healthy subjects with different axial lengths using optical coherence tomography
    Yoshikatsu Wakitani
    Department of Ophthalmology, Mie University School of Medicine, Tsu Mie, Japan
    Retina 23:177-82. 2003
    ..To evaluate the retinal thickness of the macula in healthy subjects with different axial lengths...
  72. pmc Macular thickness measurements in normal eyes with time-domain and Fourier-domain optical coherence tomography
    Jingjing Huang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Retina 29:980-7. 2009
    ..To compare macular thickness measurements using time-domain optical coherence tomography (OCT) and Fourier-domain OCT...
  73. ncbi Heritability of macular thickness determined by optical coherence tomography
    Matthew D Chamberlain
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Invest Ophthalmol Vis Sci 47:336-40. 2006
    ..To examine whether genetic factors significantly influence macular thickness in healthy older subjects...
  74. ncbi Central retinal thickness is positively correlated with macular pigment optical density
    S H Melissa Liew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Exp Eye Res 82:915-20. 2006
    ..This finding has important implications for future studies investigating MPOD, and its response to dietary modification/supplementation...
  75. ncbi Ethnic differences in macular pigment density and distribution
    Ute E K Wolf-Schnurrbusch
    Klinik und Poliklinik für Augenheilkunde, Inselspital, University Bern, Bern, Switzerland
    Invest Ophthalmol Vis Sci 48:3783-7. 2007
    ..In this study, the authors investigate ethnic differences in macular pigment density (MPD) and macular pigment (MP) distribution...
  76. ncbi Microperimetric assessment of patients with type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 48:3788-95. 2007
    ..To assess changes of the light increment sensitivity (LIS) of the macular area in patients with type 2 idiopathic macular telangiectasia (IMT)...
  77. ncbi Paramacular coloboma
    Debi Pian
    VA Greater Los Angeles Healthcare System, Santa Barbara Community Based Outpatient Clinic, Santa Barbara, CA, USA
    Optom Vis Sci 80:556-63. 2003
    ..Associated ocular findings may include blepharophimosis, situs inversus, or other anomalous retinal vascular patterns...
  78. ncbi Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (spectralis)
    Sandeep Grover
    Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL32209, USA
    Am J Ophthalmol 148:266-71. 2009
    ..To establish normative data for the macular thickness by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease...
  79. ncbi Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration
    Jan M Provis
    Research School of Biological Sciences, The Australian National University, GPO Box 475, Canberra, ACT, 2601, Australia
    Clin Exp Optom 88:269-81. 2005
    ..Both the inflammatory response and the sequelae of oxidative stress are predictable outcomes in this scenario...
  80. pmc Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 47:2305-16. 2006
    ....
  81. ncbi Distribution of macular thickness by optical coherence tomography: findings from a population-based study of 6-year-old children
    Son C Huynh
    Department of Ophthalmology, the University of Sydney and the Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Sydney, Australia
    Invest Ophthalmol Vis Sci 47:2351-7. 2006
    ..To study the distribution of macular thickness by ocular and demographic variables in a population-based study of young children...
  82. ncbi Macular thickness measured by optical coherence tomography (OCT) in diabetic patients
    R Lattanzio
    Department of Ophthalmology and Visual Sciences, University Hospital S Raffaele, Milano, Italy
    Eur J Ophthalmol 12:482-7. 2002
    ....
  83. pmc Topography of diabetic macular edema with optical coherence tomography
    M R Hee
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, USA
    Ophthalmology 105:360-70. 1998
    ..The topographic mapping protocol provided geographic information on macular thickness that was intuitive and objective...
  84. ncbi Regional variations in the relationship between macular thickness measurements and myopia
    Dennis Shun Chiu Lam
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
    Invest Ophthalmol Vis Sci 48:376-82. 2007
    ..To investigate the relationship between myopia and macular thickness, as measured by optical coherence tomography...
  85. ncbi Serous macular detachment associated with retinal arterial macroaneurysm
    Kyoichi Takahashi
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Jpn J Ophthalmol 50:460-4. 2006
    ..To report optical coherence tomography (OCT) findings of macular edema secondary to retinal arterial macroaneurysms...
  86. ncbi Serous retinal detachment and cystoid macular edema in hypotony maculopathy
    G T Kokame
    Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii 96701, USA
    Am J Ophthalmol 131:384-6. 2001
    ..To report the foveal structural findings of hypotony maculopathy imaged with optical coherence tomography...
  87. ncbi Immunological and aetiological aspects of macular degeneration
    P L Penfold
    Department Clinical Ophthalmology, Save Sight Institute, University of Sydney, NSW 2006, Australia
    Prog Retin Eye Res 20:385-414. 2001
    ....
  88. ncbi Repeatability and reproducibility of macular thickness measurements with the Humphrey OCT system
    Sarah Muscat
    Tennent Institute of Ophthalmology, University of Glasgow, Glasgow, United Kingdom
    Invest Ophthalmol Vis Sci 43:490-5. 2002
    ..To assess the accuracy, precision, repeatability, and reproducibility of measurements made by the Humphrey optical coherence tomography (OCT) system (Humphrey-Zeiss Medical Systems, San Leandro, CA)...
  89. ncbi Natural course of macular retinoschisis in highly myopic eyes without macular hole or retinal detachment
    Noriaki Shimada
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Am J Ophthalmol 142:497-500. 2006
    ..To investigate the natural course of macular retinoschisis in highly myopic patients...
  90. pmc Macular infarction after intravitreal amikacin: mounting evidence against amikacin
    G Galloway
    Br J Ophthalmol 86:359-60. 2002
  91. ncbi Patients with Sjögren-Larsson syndrome lack macular pigment
    Rob L P VAN DER Veen
    University Eye Clinic, Maastricht, The Netherlands
    Ophthalmology 117:966-71. 2010
    ..Ophthalmic symptoms in SLS are reduced visual acuity and photophobia. This article reports the deficiency of macular pigment as a novel finding in this peculiar, congenital maculopathy...
  92. ncbi Prediction of macular edema exacerbation after phacoemulsification in patients with nonproliferative diabetic retinopathy
    Hideharu Funatsu
    Department of Ophthalmology, Diabetes Center, Tokyo Women s Medical University, Tokyo, Japan
    J Cataract Refract Surg 28:1355. 2002
    ....
  93. ncbi Development of macular pseudoholes: a 36-month period of follow-up
    Monica Varano
    Fondazione per l Oftalmologia G B Bietti, Rome, Italy
    Retina 22:435-42. 2002
    ..To assess the changes in visual acuity and macular sensitivity and the possible evolution into a full-thickness macular hole in patients with macular pseudoholes during a 3-year follow-up period...
  94. ncbi Role of OCT in the diagnosis and follow up of diabetic macular edema
    Giacomo Panozzo
    TECLO SRL, Vitreoretinal Service, Verona, Italy
    Semin Ophthalmol 18:74-81. 2003
    ..We think that this tool should always be used in monitoring the effect of therapies in future studies...
  95. ncbi Macular thickness assessment in healthy eyes based on ethnicity using Stratus OCT optical coherence tomography
    Patrick J Kelty
    Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 49:2668-72. 2008
    ..To assess the variation in macular thickness measurements in healthy Caucasian and African American men and women through Stratus OCT optical coherence tomography (OCT-3)...
  96. ncbi Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:1172-7. 2008
    ..To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT)...
  97. ncbi Analysis of macular thickness in British population using optical coherence tomography (OCT): an emphasis on interocular symmetry
    Mohamed El-Ashry
    Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom
    Curr Eye Res 33:693-9. 2008
    ..To evaluate macular thickness measurements in normal subjects from British origin, to assess interocular asymmetry using optical coherence tomography (OCT) and to establish standard values for macular and foveal thickness...
  98. ncbi Causes of macular serous retinal detachments in Japanese patients 40 years and older
    Taiichi Hikichi
    Ohtsuka Eye Hospital, Sapporo, Japan
    Retina 29:395-404. 2009
    ..To investigate the causes of macular serous retinal detachment without hemorrhage at the macula in patients 40 years and older...
  99. doi Macular infarction after intravitreal ganciclovir injection in a patient with acute retinal necrosis
    Seong Woo Kim
    Can J Ophthalmol 43:124-5. 2008
  100. ncbi Temporal variation in diabetic macular edema measured by optical coherence tomography
    Robert N Frank
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ophthalmology 111:211-7. 2004
    ..To determine, by optical coherence tomography (OCT), whether there is a quantitative decrease in macular edema in diabetic subjects over the course of a day...
  101. pmc Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
    Zhenglin Yang
    Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, China
    N Engl J Med 359:1456-63. 2008
    ..Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown...

Research Grants50

  1. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2013
    ..zeaxanthin, and their metabolites are dietary xanthophyll carotenoids that are specifically concentrated in the macula lutea of the human eye where they are thought to provide protection against degenerative diseases of the retina ..
  2. Developing Small Molecules to Potentiate RNA Interference
    Peng Jin; Fiscal Year: 2010
    ..Age-related macular degeneration (AMD) is a condition in which cells of the macula lutea degenerate, resulting in blurred vision and ultimately blindness...
  3. Central Scotomas in AMD and Cortical Remapping
    Janet Sunness; Fiscal Year: 2005
    ....
  4. RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMS
    Xiangrun Huang; Fiscal Year: 2007
    ..Birefringence is an intrinsic property of the tissue, depends directly on RNFL ultrastructure, and may provide a means of early detection of structural damage to ganglion cells in glaucoma. ..
  5. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
    ..The proposed studies will provide needed data on relationships among AMD, lipofuscin and macular pigment, estimate genetic contribution to the latter, and assist identification of individuals at greatest risk for vision loss. ..
  6. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  7. Perceptual encoding and imagery in prosopagnosia
    Jason Barton; Fiscal Year: 2008
    ..From our prior work, we hypothesize that covert or unconscious recognition is the residual product of a partially damaged face network in the brain. We propose a functional imaging experiment to test this hypothesis. ..
  8. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  9. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  10. RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS
    Werner Gellermann; Fiscal Year: 2002
    ..Furthermore, we propose a series of clinical studies in humans to validate its function and to begin to establish its role as a possible screening test for AMD. PROPOSED COMMERCIAL APPLICATION: Screening of macular pigment levels. ..
  11. The Subproteome in Age-related Macular Degeneration
    Timothy Olsen; Fiscal Year: 2008
    ..This information will enable us to generate a rational approach to identify targeted therapies. ..
  12. The Choriocapillaris in Aging and Macular Disease
    Robert Mullins; Fiscal Year: 2005
    ..These experiments are expected to provide novel insights into the potential role of the choriocapillaris in the pathobiology of AMD. ..
  13. CYTOKINE MODULATION IN PROLIFERATIVE VITREORETINOPATHY
    GLENN JAFFE; Fiscal Year: 2005
    ..Density-dependent effects of IL-1, TNFalpha, and specific NF-kappaB inhibitors on NF-kappaB-mediated RPE apoptosis will be quantified. IV) To determine whether specific in vivo NF-kappaB blockade inhibits PVR. ..
  14. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  15. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2005
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  16. Single Shot OCT
    Daniel Hammer; Fiscal Year: 2006
    ..In addition, the developed instrument and the principles upon which it is based may be used to image other disease types throughout the human body. [unreadable] [unreadable] [unreadable]..
  17. Caloric Restriction and Aging in Eyes
    Peter Gouras; Fiscal Year: 2010
    ..Because many of these primates are near the end of their lifespan, there is an element of urgency in our goal to correlate noninvasive clinical testing prior with post mortem histology. ..
  18. Compact Line-scanning Adaptive Optics Retinal Imager
    Daniel Hammer; Fiscal Year: 2007
    ..These researchers will, in turn, use this tool to increase our understanding of vision and its disruption by disease and for the development of new drugs and therapies. [unreadable] [unreadable] [unreadable]..
  19. Murine Age-related Macular Degeneration: Model of Known Human Risk Factors
    Catherine Bowes Rickman; Fiscal Year: 2007
    ..Analysis of these animals will provide insight into the pathogenesis of AMD as well as a means to separate the relative contribution and degenerative effects of specific risk factors. [unreadable] [unreadable] [unreadable]..
  20. Stabilized Adaptive Optics Imaging Laser Microsurgery
    Daniel Hammer; Fiscal Year: 2004
    ..abstract_text> ..
  21. CAROTENOIDS & AGE-RELATED EYE DISEASE IN WOMEN'S HEALTH
    Julie Mares; Fiscal Year: 2004
    ..abstract_text> ..
  22. OCULAR MELANOMA
    Dennis Robertson; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed; and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  23. Eye Disease in Cuban-American and Puerto Rican Adults
    Ingrid Scott; Fiscal Year: 2003
    ..g. NEI-VFQ 25) and eye service use. Subjects who refuse will be questioned as to reason(s) for refusal. ..
  24. Telemedical Diagnosis of Retinopathy of Prematurity
    Michael Chiang; Fiscal Year: 2007
    ..Columbia University has a strong existing framework in medical information systems, telemedicine, and public health, which will be leveraged to complete this training and research program successfully. ..
  25. Dietary Fatty Acids and Photoreceptor Function
    Martha Neuringer; Fiscal Year: 2003
    ..They also will contribute to understanding the changes in retinal function found in human infants fed diets lacking DHA or its precursors. ..
  26. Real-Time Three-Dimensional Motion Control Tracker
    Daniel Hammer; Fiscal Year: 2003
    ..After optimization, the Phase II instrument will be tested in a clinical ophthalmic program and the improvement in measurement of retinal features (e.g., nerve fiber layer thickness) will be quantified. ..
  27. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  28. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  29. Graduate Medical Education in Genetics
    Margaret McGovern; Fiscal Year: 2004
    ..abstract_text> ..
  30. 2007 Carotenoids Gordon Research Conference
    John Landrum; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. Quan11tification of Glaucomatous Optic Neuropathy
    Christopher Girkin; Fiscal Year: 2006
    ....
  32. MODULATION OF CORTICAL ACTIVITY BY EYE MOVEMENTS
    D Snodderly; Fiscal Year: 2002
    ..The results will be relevant to human visual perception, as well as in vivo imaging of human visual function. ..
  33. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 2003
    ..BUDGET NOTE: NEI Staff should evaluate the requested budget in light of their experience with the budget needs of reading centers in other clinical trials. ADMINISTRATIVE NOTE: Awards, if made, are limited to 5 years. ..
  34. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Donald Budenz; Fiscal Year: 2008
    ....
  35. OCULAR MELANOMA
    Judy Kim; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  36. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  37. RETINAL PATHOPHYSIOLOGY OF INFANTS AND ADULTS
    David Birch; Fiscal Year: 2005
    ..In the mouse models, cone measures will necessarily focus on the b-wave, using monochromatic stimuli, long-duration flashes, and flicker to optimize isolation of cone from rod responses. ..
  38. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  39. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  40. Low-Cost Device for Digital Retinal Imaging
    Ann E Elsner; Fiscal Year: 2010
    ..While this project focuses on diabetic retinopathy in humans, future applications include other retinal disorders in both humans and animal models. ..
  41. Low-Cost Device for Digital Retinal Imaging
    ANN ELSNER; Fiscal Year: 2007
    ..We will investigate the key features considered necessary for early detection grading, and also more the serious damage that is typically discovered late in the rural and urban underserved. ..
  42. Retinal Microvascular Characteristics/Vascular Disorders
    Ronald Klein; Fiscal Year: 2003
    ..abstract_text> ..
  43. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2008
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  44. HYDRODYNAMICS OF AQUEOUS HUMOR OUTFLOW
    Mark Johnson; Fiscal Year: 2007
    ..We will examine this possibility in our proposed studies. If confirmed, these findings may finally allow us to find the ultimate cause of the elevated IOP characteristic of glaucoma. ..
  45. A Freeze-Fracture & Etching System for Northwestern Univ
    Mark Johnson; Fiscal Year: 2002
    ..abstract_text> ..
  46. Reading Enhancement for Patients with Visual Field Loss
    MICHAEL SANDBERG; Fiscal Year: 2004
    ....
  47. Bioengineering of Transport Across Bruch's Membrance
    Mark Johnson; Fiscal Year: 2006
    ..abstract_text> ..
  48. Microvascular - Macrovascular Disease in Type 2 Diabetes
    Ronald Klein; Fiscal Year: 2005
    ....
  49. Melanopsin-based form vision in photoreceptor disease
    MICHAEL SANDBERG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  50. Proteomic Analysis of the Retina
    MONICA JABLONSKI; Fiscal Year: 2007
    ..These studies will also generate the framework for future project periods in which the precise molecular mechanisms and detailed pathways that control photoreceptor outer segment assembly will be determined. [unreadable] [unreadable]..