trabecular meshwork

Summary

Summary: A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm.

Top Publications

  1. pmc Extracellular matrix in the trabecular meshwork
    Ted S Acott
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger, Portland, OR 97239 4197, USA
    Exp Eye Res 86:543-61. 2008
  2. pmc Extracellular matrix turnover and outflow resistance
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239 4197, USA
    Exp Eye Res 88:676-82. 2009
  3. pmc Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells
    Guorong Li
    Department of Ophthalmology, Duke University, Durham, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:2999-3007. 2011
  4. ncbi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008
  5. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
  6. pmc Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 12:774-90. 2006
  7. ncbi In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 43:151-61. 2002
  8. pmc Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress
    Coralia Luna
    Department of Ophthalmology, Duke University, Durham, NC
    Mol Vis 15:2488-97. 2009
  9. ncbi Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta
    Xiujun Zhao
    Section on Aging and Ocular Disease, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:4023-34. 2004
  10. pmc Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma
    John Kuchtey
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS Genet 7:e1001306. 2011

Detail Information

Publications274 found, 100 shown here

  1. pmc Extracellular matrix in the trabecular meshwork
    Ted S Acott
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger, Portland, OR 97239 4197, USA
    Exp Eye Res 86:543-61. 2008
    The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in regulating intraocular pressure (IOP) in both normal and glaucomatous eyes...
  2. pmc Extracellular matrix turnover and outflow resistance
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239 4197, USA
    Exp Eye Res 88:676-82. 2009
    ..adjustment of elevated intraocular pressure (IOP) involves remodeling the extracellular matrix (ECM) of the trabecular meshwork (TM)...
  3. pmc Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells
    Guorong Li
    Department of Ophthalmology, Duke University, Durham, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:2999-3007. 2011
    To investigate the biological functions of miR-204 in human trabecular meshwork (HTM) cells.
  4. ncbi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008
    ..The authors provide evidence that mitochondrial dysfunction is a possible mechanism for the loss of trabecular meshwork (TM) cells in persons with POAG.
  5. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
    ..A gene encoding a trabecular meshwork protein (TIGR) mapped to the narrowest disease interval by STS content and radiation hybrid mapping...
  6. pmc Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 12:774-90. 2006
    To contrast genome-wide gene expression profiles of cultured human trabecular meshwork (HTM) cells to that of control and primary open angle glaucoma (POAG) HTM tissues.
  7. ncbi In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 43:151-61. 2002
    To determine whether trabecular meshwork-inducible glucocorticoid response/myocilin (TIGR/MYOC) protein associates with the extracellular matrix (ECM) of human trabecular meshwork (HTM) cells.
  8. pmc Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress
    Coralia Luna
    Department of Ophthalmology, Duke University, Durham, NC
    Mol Vis 15:2488-97. 2009
    To investigate the role of miR-29b on the changes in expression of genes involved in the synthesis and deposition of extracellular matrix (ECM) induced by chronic oxidative stress in human trabecular meshwork cells (HTM).
  9. ncbi Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta
    Xiujun Zhao
    Section on Aging and Ocular Disease, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:4023-34. 2004
    To determine the genomic and proteomic expression changes in human trabecular meshwork cells when they are treated with transforming growth factor (TGF)-beta.
  10. pmc Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma
    John Kuchtey
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS Genet 7:e1001306. 2011
    ..Increased resistance to outflow of aqueous humor through the trabecular meshwork causes elevated intraocular pressure, but the specific mechanisms are unknown...
  11. pmc Interactions between endothelia of the trabecular meshwork and of Schlemm's canal: a new insight into the regulation of aqueous outflow in the eye
    Jorge A Alvarado
    Department of Ophthalmology, University of California San Francisco, USA
    Trans Am Ophthalmol Soc 103:148-62; discussion 162-3. 2005
    To test the hypothesis that trabecular meshwork endothelial cells (TMEs) regulate aqueous outflow by actively releasing ligands that upon binding to Schlemm's canal endothelial cells (SCEs) increase transendothelial flow, thereby ..
  12. ncbi Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma
    Robert J Wordinger
    Department of Cell Biology and Genetics, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 48:1191-200. 2007
    ..aqueous humor (AH) outflow resistance, which is associated with morphologic and biochemical changes in the trabecular meshwork (TM)...
  13. ncbi Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells
    T D Nguyen
    Cellular Pharmacology Laboratories, Department of Ophthalmology, School of Medicine, University of California, San Francisco, California 94143 0730, USA
    J Biol Chem 273:6341-50. 1998
    Expression of the trabecular meshwork inducible glucocorticoid response (TIGR) gene progressively increases from barely detectable levels to greater than 2% of total cellular mRNA over 10 days exposure of trabecular meshwork (TM) cells ..
  14. ncbi Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    Tayebeh Rezaie
    Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:1077-9. 2002
    ..Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role.
  15. ncbi Structural changes of the trabecular meshwork in different kinds of glaucoma
    Ozan Yüksel Tektas
    University of Erlangen Nurnberg, Department of Anatomy II, Erlangen, Germany
    Exp Eye Res 88:769-75. 2009
    The morphology of the trabecular meshwork in three types of open angle glaucoma: primary open angle glaucoma (POAG), corticosteroid-induced glaucoma and pigmentary glaucoma (PG) are described...
  16. ncbi The role of steroids in outflow resistance
    Abbot F Clark
    Department of Cell Biology and Genetics, University North Texas Health Science Center, Ft Worth, TX 76107, USA
    Exp Eye Res 88:752-9. 2009
    ..glaucoma, including increased aqueous outflow resistance and morphological and biochemical changes to the trabecular meshwork (TM). Therefore, a large number of studies have examined the effects of GCs on TM cells and tissues...
  17. ncbi Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632
    P V Rao
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina7710, USA
    Invest Ophthalmol Vis Sci 42:1029-37. 2001
    ..Rho kinase, a critical downstream effector of Rho GTPase is recognized to control the formation of actin stress fibers, focal adhesions, and cellular contraction...
  18. ncbi Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma
    Alberto Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, Genoa, Italy
    Invest Ophthalmol Vis Sci 50:5251-8. 2009
    ..It contains the aqueous humor, secreted by the ciliary body and drained by the trabecular meshwork. Alteration of aqueous humor homeostasis plays a major role in the pathogenesis of glaucoma...
  19. pmc 'What controls aqueous humour outflow resistance?'
    Mark Johnson
    Department of Biomedical Engineering, Northwestern University, TECH E378, 2145 Sheridan Road, Evanston, IL 60208, USA
    Exp Eye Res 82:545-57. 2006
    ....
  20. ncbi Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 48:1164-72. 2007
    Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling...
  21. pmc Quantitative proteomics: TGFβ₂ signaling in trabecular meshwork cells
    Kathryn E Bollinger
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Invest Ophthalmol Vis Sci 52:8287-94. 2011
    Transforming growth factor beta 2 (TGFβ₂) is often elevated in the aqueous humor (AH) and trabecular meshwork (TM) of patients with primary open-angle glaucoma (POAG) and appears to contribute to POAG pathogenesis...
  22. pmc Current understanding of conventional outflow dysfunction in glaucoma
    W Daniel Stamer
    Department of Ophthalmology, Duke University, Durham, North Carolina 27710, USA
    Curr Opin Ophthalmol 23:135-43. 2012
    ..In the context of established knowledge, this review summarizes recent investigations of conventional outflow function, with the goal of identifying areas for future inquiry and therapeutic targeting...
  23. pmc Specialized podosome- or invadopodia-like structures (PILS) for focal trabecular meshwork extracellular matrix turnover
    Mini Aga
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Invest Ophthalmol Vis Sci 49:5353-65. 2008
    There are distinctive areas of colocalization of matrix metalloproteinase (MMP)-2 and -14 on trabecular meshwork (TM) cells that resemble podosomes or invadopodia...
  24. pmc Elastic modulus determination of normal and glaucomatous human trabecular meshwork
    Julie A Last
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 52:2147-52. 2011
    ..The principal outflow pathway for aqueous humor in the human eye is through the trabecular meshwork (HTM) and Schlemm's canal (SC)...
  25. ncbi Elasticity-dependent modulation of TGF-β responses in human trabecular meshwork cells
    Hong Han
    Department of Ophthalmology, Würzburg University Hospital, Wurzburg, Germany
    Invest Ophthalmol Vis Sci 52:2889-96. 2011
    To gain further insight into a possible role of biomechanical cues in glaucoma, the authors assessed the influence of extracellular matrix (ECM) elasticity on TGF-β2-induced changes in trabecular meshwork (TM) cells.
  26. ncbi Constitutive secretion of chemokines by cultured human trabecular meshwork cells
    Amde Selassie Shifera
    Department of Ophthalmology, University of California, San Francisco, 10 Koret Way, San Francisco, CA 94143 0730, USA
    Exp Eye Res 91:42-7. 2010
    b>Trabecular meshwork endothelial (TME) cells secrete a number of factors, such as enzymes and cytokines, which modulate the functions of the cells and the extracellular matrix of the conventional aqueous outflow pathway...
  27. pmc Two-photon imaging of the trabecular meshwork
    David A Ammar
    Department of Ophthalmology, University of Colorado Denver, Aurora, CO, USA
    Mol Vis 16:935-44. 2010
    To image the trabecular meshwork (TM) in its native unfixed state using a non-invasive, non-destructive technique.
  28. ncbi The trabecular meshwork outflow pathways: structural and functional aspects
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 88:648-55. 2009
    ..for aqueous humor (AH) are the conventional or trabecular outflow pathways, which are comprised of the trabecular meshwork (made up by the uveal and corneoscleral meshworks), the juxtacanalicular connective tissue (JCT), the ..
  29. ncbi Monocyte modulation of aqueous outflow and recruitment to the trabecular meshwork following selective laser trabeculoplasty
    Jorge A Alvarado
    Department of Ophthalmology, University of California, San Francisco, CA 94143 0730, USA
    Arch Ophthalmol 128:731-7. 2010
    To determine whether selective laser trabeculoplasty (SLT) induces monocyte recruitment to the trabecular meshwork (TM) in human and monkey eyes and whether monocytes increase both aqueous outflow in vivo and the conductivity of human ..
  30. ncbi Gene expression in the trabecular meshwork and the influence of intraocular pressure
    TERESA BORRAS
    Department of Ophthalmology, University of North Carolina School of Medicine, 6109 Neuroscience Research Building, Campus, Box 7041, Chapel Hill, NC 27599, USA
    Prog Retin Eye Res 22:435-63. 2003
    The trabecular meshwork (TM) tissue is responsible for maintaining the physiologic intraocular pressure (IOP) of the ocular globe. To perform this function the TM must rely on a variety of mechanisms...
  31. pmc Development of a gene therapy virus with a glucocorticoid-inducible MMP1 for the treatment of steroid glaucoma
    Maria Grazia Spiga
    Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7041, USA
    Invest Ophthalmol Vis Sci 51:3029-41. 2010
    To design a glucocorticoid-inducible virus vector overexpressing recombinant matrix metalloproteinase 1 (MMP1) and counteract extracellular matrix deposition in the trabecular meshwork only when steroid is present.
  32. ncbi Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues
    Alice L Yu
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Invest Ophthalmol Vis Sci 49:4872-80. 2008
    The trabecular meshwork (TM) of glaucomatous eyes is characterized by cell loss, increased accumulation of extracellular matrix (ECM), and cellular senescence...
  33. ncbi Mitochondrial damage in the trabecular meshwork of patients with glaucoma
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Arch Ophthalmol 128:724-30. 2010
    ..Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species...
  34. pmc Sustained stress response after oxidative stress in trabecular meshwork cells
    Guorong Li
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 13:2282-8. 2007
    To investigate the mechanisms by which chronic oxidative stress may lead to a sustained stress response similar to that previously observed in the trabecular meshwork (TM) of glaucoma donors.
  35. ncbi Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones
    P Gonzalez
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
    Invest Ophthalmol Vis Sci 41:3678-93. 2000
    To study the gene expression profile of the human trabecular meshwork (HTM).
  36. ncbi What increases outflow resistance in primary open-angle glaucoma?
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Germany
    Surv Ophthalmol 52:S101-4. 2007
    Intraocular pressure, the most critical risk factor for primary open-angle glaucoma is generated in the trabecular meshwork outflow pathways, which provide resistance to aqueous humor outflow...
  37. pmc Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Invest Ophthalmol Vis Sci 50:5769-77. 2009
    ..In this study, the authors examined the effects of ADAMTS-1, -4, and -5 on outflow facility and investigated their mRNA levels and protein expression in the trabecular meshwork (TM).
  38. ncbi Comparison of the morphologic changes after selective laser trabeculoplasty and argon laser trabeculoplasty in human eye bank eyes
    T R Kramer
    Emory Eye Center, Emory University School of Medicine, 1365-B Clifton Road N.E, Atlanta, GA 30322, USA
    Ophthalmology 108:773-9. 2001
    OBJECTIVE: To compare the histopathologic changes in the human trabecular meshwork (TM) after argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT) with a Q-switched, frequency-doubled, neodymium:yttrium-aluminum-..
  39. pmc The role of the actomyosin system in regulating trabecular fluid outflow
    Baohe Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792 3220, USA
    Exp Eye Res 88:713-7. 2009
    Abnormally high resistance to aqueous humor drainage via the trabecular meshwork and Schlemm's canal is highly correlated with the development of primary open-angle glaucoma...
  40. pmc Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress
    Paloma B Liton
    Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA
    Invest Ophthalmol Vis Sci 49:3961-9. 2008
    To investigate the effects of chronic oxidative stress on lysosomal function in trabecular meshwork (TM) cells.
  41. ncbi Effects of TGF-beta2 in perfused human eyes
    Johannes Gottanka
    Department of Anatomy 2, University of Erlangen Nuremburg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 45:153-8. 2004
    ..Studies have shown that TGF-beta2 influences cultured trabecular meshwork (TM) cells, but the effects of this cytokine on intact TM and outflow facility have not been studied...
  42. pmc PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3
    M Hermina Strungaru
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada
    Invest Ophthalmol Vis Sci 52:7625-33. 2011
    ..In this study, the authors investigated genes directly regulated by the PITX2 transcription factor to gain insight into the mechanisms underlying these disorders...
  43. ncbi Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway
    Naoya Miyamoto
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 52:1055-63. 2011
    ..The purpose of this study was to investigate whether quercetin can activate transcription factors and induce the expression of the PRDX family...
  44. pmc Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells
    Jessica Chow
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 13:1926-33. 2007
    ..of this study were to evaluate the potential release of ATP that is mediated by mechanical stress on trabecular meshwork (TM) cells, to identify the specific P2Y receptors mediating the ATP response, and to determine whether ..
  45. ncbi Optical coherence tomography imaging of the anterior chamber angle
    Sunita Radhakrishnan
    Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Ophthalmol Clin North Am 18:375-81, vi. 2005
    ..It has the potential for use as a rapid screening tool for detection of occludable angles. Ongoing clinical studies should help to evaluate its efficacy in this regard...
  46. ncbi Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells
    Benjamin Junglas
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 88:1065-75. 2009
    The major structural change in the human trabecular meshwork (TM) of eyes with primary open-angle glaucoma (POAG) is an increase in extracellular matrix (ECM) in the juxtacanalicular region of the TM...
  47. pmc Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Invest Ophthalmol Vis Sci 49:2495-505. 2008
    ..GAGs) have been implicated in the regulation of outflow resistance of aqueous humor flow through the trabecular meshwork (TM)...
  48. pmc Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 15:326-34. 2009
    ..the relationship between transforming growth factor beta-1 (TGF-beta1) and interleukin-6 (IL-6) in human trabecular meshwork (HTM) cells as well as to identify the signaling pathway/s involved in the increased IL-6 expression that ..
  49. pmc Identification of the active site in the heparin II domain of fibronectin that increases outflow facility in cultured monkey anterior segments
    Jose M Gonzalez
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Invest Ophthalmol Vis Sci 50:235-41. 2009
    To determine the active site in the Heparin II (HepII) domain of fibronectin that regulates outflow facility in cultured anterior segments and disrupts the actin cytoskeleton in transformed human trabecular meshwork (TM-1) cells.
  50. ncbi Effects of prostaglandin analogues on human ciliary muscle and trabecular meshwork cells
    Xiujun Zhao
    Laboratory of Mechanisms of Ocular Diseases, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 44:1945-52. 2003
    To determine the effects of prostaglandin F(2alpha) analogues on gene expression of human ciliary muscle (HCM) and trabecular meshwork (HTM) cells.
  51. ncbi Modulation of extracellular matrix turnover in the trabecular meshwork
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 88:683-8. 2009
    ..because of an abnormally high aqueous humor outflow resistance in the juxtacanalicular region of the trabecular meshwork. A distinct structural change in the trabecular meshwork of patients with POAG is the increase in fibrillar ..
  52. ncbi Future possibilities in glaucoma therapy
    Joanna Wierzbowska
    Department of Ophthalmology, Military Medical Institute, Warsaw, Poland
    Med Sci Monit 16:RA252-9. 2010
    ..rho-kinase inhibitors, latrunculin, cytochalasin), new drugs that enhance aqueous outflow via the trabecular meshwork (statins, steroid antagonists) and via the uveoscleral route (EP2 agonists, 5-HT2 agonists), as well as new ..
  53. ncbi [Oxidative stress in the trabecular meshwork of POAG]
    U Welge-Lussen
    Augenklinik, Universitat Erlangen Nurnberg
    Klin Monbl Augenheilkd 227:99-107. 2010
    ..Morphological and biochemical analyses of the trabecular meshwork (TM) of POAG patients revealed loss of cells, increased accumulation of extracellular matrix (ECM), changes ..
  54. ncbi Senescent phenotype of trabecular meshwork cells displays biomarkers in primary open-angle glaucoma
    M A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    Curr Mol Med 11:528-52. 2011
    ..High IOP usually occurs as a result of an increase in aqueous humor outflow resistance in trabecular meshwork (TM)...
  55. pmc Label-free imaging of trabecular meshwork cells using Coherent Anti-Stokes Raman Scattering (CARS) microscopy
    Tim C Lei
    Department of Electrical Engineering, University of Colorado Denver, Denver, CO, USA
    Mol Vis 17:2628-33. 2011
    To image the human trabecular meshwork (TM) using a non-invasive, non-destructive technique without the application of exogenous label.
  56. pmc Segmental versican expression in the trabecular meshwork and involvement in outflow facility
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 52:5049-57. 2011
    ..To assess versican's potential contributions to aqueous humor outflow resistance, its segmental distribution in the trabecular meshwork (TM) and the effect on outflow facility of silencing the versican gene were evaluated.
  57. pmc Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells
    Fang Chai
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Vis 16:1122-31. 2010
    ..marker of endoplasmic reticulum (ER) stress, we investigated and analyzed GRP78 expression levels in the trabecular meshwork (TM) by eyes with primary open angle glaucoma (POAG) and normal eyes to understand the role of GRP78 in ..
  58. pmc Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells
    Anirudh Sethi
    Department of Cell Biology and Anatomy, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 52:5240-50. 2011
    ..with glaucoma and plays an important role in the regulation of extracellular matrix metabolism in the trabecular meshwork (TM)...
  59. pmc MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN
    Coralia Luna
    Department of Ophthalmology, Duke University, Durham, North Carolina 27710, USA
    J Cell Physiol 226:1407-14. 2011
    Cyclic mechanical stress (CMS) leads to alterations of cellular functions in the trabecular meshwork (TM), including the up-regulation of transforming growth factor beta 1 (TGFβ1), that can potentially contribute to the pathogenesis of ..
  60. pmc Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma
    Nuria Comes
    Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Genes Cells 16:243-59. 2011
    The trabecular meshwork tissue controls the drainage of the aqueous humor of the eye. A dysfunctional trabecular meshwork leads to an altered fluid resistance, which results in increased intraocular pressure (IOP)...
  61. pmc Serial analysis of gene expression (SAGE) in normal human trabecular meshwork
    Yutao Liu
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Mol Vis 17:885-93. 2011
    To identify the genes expressed in normal human trabecular meshwork tissue, a tissue critical to the pathogenesis of glaucoma.
  62. pmc Dexamethasone-associated cross-linked actin network formation in human trabecular meshwork cells involves β3 integrin signaling
    Mark S Filla
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, USA
    Invest Ophthalmol Vis Sci 52:2952-9. 2011
    To determine whether cross-linked actin networks (CLANs) formed in dexamethasone (DEX)-treated human trabecular meshwork (HTM) cells are structurally similar to those formed after β3 integrin activation and involve αvβ3 integrin ..
  63. pmc Progenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma
    Wing Yan Yu
    Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    J Biomed Biotechnol 2011:412743. 2011
    ..area between the peripheral corneal endothelium (CE) and the anterior nonfiltering portion of the trabecular meshwork (TM), which is known as the Schwalbe's Ring region...
  64. pmc Influence of lipophilicity on drug partitioning into sclera, choroid-retinal pigment epithelium, retina, trabecular meshwork, and optic nerve
    Rajendra S Kadam
    Department of Pharmaceutical Sciences, University of Colorado Denver, 12700 E 19th Ave, Aurora, CO 80045, USA
    J Pharmacol Exp Ther 332:1107-20. 2010
    ..In intact tissue methods, Kt:b followed the order choroid-retinal pigment epithelium (RPE) > trabecular meshwork > retina > sclera approximately optic nerve; propranolol > betaxolol > pindolol approximately ..
  65. pmc Coordinated regulation of extracellular matrix synthesis by the microRNA-29 family in the trabecular meshwork
    Guadalupe Villarreal
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:3391-7. 2011
    ..In this study, the authors investigate the role of the miR-29 family in the regulation of ECM synthesis in the trabecular meshwork (TM) under basal and TGF-β2 stimulatory conditions.
  66. pmc Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells
    Moulinath Acharya
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 284:34829-38. 2009
    ..Yeast two-hybrid screening was performed using a cDNA library from a human trabecular meshwork primary cell line to detect novel PITX2-interacting proteins and study their role in ARS pathogenesis...
  67. pmc Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 50:5723-31. 2009
    ..beta1/beta3 integrin-mediated pathways that regulate cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells...
  68. pmc Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells
    C Ramachandran
    School of Optometry, Indiana University, Bloomington, IN 47405, USA
    Mol Vis 17:1877-90. 2011
    The outflow facility for aqueous humor across the trabecular meshwork (TM) is enhanced by agents that oppose the actomyosin contraction of its resident cells...
  69. ncbi Transduction of TAT fusion proteins into the human and bovine trabecular meshwork
    Hiroshi Sakai
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Invest Ophthalmol Vis Sci 47:4427-34. 2006
    ..of TAT (the protein transduction domain of transactivating transcription polypeptide)-mediated protein-transduction technology, in introducing proteins of interest into trabecular meshwork (TM) cells in various culture systems.
  70. pmc The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes
    Zhaozeng Lu
    Huashan Hospital of Fudan University, Shanghai, PR China
    Exp Eye Res 86:271-81. 2008
    ..03). Control eyes showed segmental distribution of tracer in the trabecular meshwork tending to cluster near collector channel ostia, whereas Y-27-treated eyes showed a more uniform pattern ..
  71. ncbi Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma
    Yuyan Zhang
    Huashan Hospital of Fudan University, Shanghai, People s Republic of China
    Exp Eye Res 89:748-56. 2009
    ..Argon laser photocoagulation burns to the trabecular meshwork (TM) were made in one eye of each monkey (N = 3), leaving the contralateral eye as a normotensive control...
  72. ncbi Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma
    Sergio Claudio Saccà
    Department of Neurosciences, Clinica Oculistica, University of Genoa, I 16132 Genoa, Italy
    Arch Ophthalmol 123:458-63. 2005
    ..To evaluate the intensity of oxidative molecular damage and its clinical correlations: visual field damage, intraocular pressure, age, and disease duration...
  73. pmc Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 88:1020-32. 2009
    A distinct structural change in the trabecular meshwork (TM) of patients with primary open-angle glaucoma (POAG) is the increase in fibrillar extracellular matrix (ECM) in the juxtacanalicular region of the TM...
  74. pmc Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 46:183-90. 2005
    To compare the gene expression profile of trabecular meshwork (TM) and Schlemm's canal (SC) primary cultures and to identify promoters for targeting gene expression to specific cells in the outflow pathway.
  75. ncbi Histologic findings in pigment dispersion syndrome and pigmentary glaucoma
    Johannes Gottanka
    Department of Anatomy, University of Erlangen Nurnberg, Erlangen, Germany
    J Glaucoma 15:142-51. 2006
    To investigate the morphologic changes in the trabecular meshwork in a case series of eyes with pigment dispersion syndrome and pigmentary glaucoma, and surgical trabeculectomy specimens from eyes with pigmentary glaucoma.
  76. pmc Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells
    Coralia Luna
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 15:534-44. 2009
    To investigate the changes in gene expression induced by cyclic mechanical stress (CMS) in trabecular meshwork (TM) cells.
  77. pmc Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure
    Wan Heng Wang
    Alcon Research Ltd, Fort Worth, Texas 76134, USA
    J Clin Invest 118:1056-64. 2008
    ..This abnormality likely originates from outflow pathway tissues such as the trabecular meshwork (TM), but the associated molecular etiology is poorly understood...
  78. ncbi Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction
    C Fukiage
    Research Laboratories, Senju Pharmaceutical Corporation Ltd, Kobe 651-2241, Japan
    Biochem Biophys Res Commun 288:296-300. 2001
    ..kinase) in monkey and rabbit eye tissues and (ii) measure phosphorylation of ROCK substrate during trabecular meshwork or ciliary muscle contraction induced by carbachol...
  79. pmc Biological properties of trabecular meshwork cells
    Joshua Z Gasiorowski
    School of Veterinary Medicine, University of Wisconsin Madison, Department of Surgical Sciences, Madison, WI 53706, USA
    Exp Eye Res 88:671-5. 2009
    ..However, recent advances in culturing and manipulating human trabecular meshwork cells may provide a means to elucidate some of the mechanisms that cause glaucoma...
  80. ncbi The identification of myocilin-associated proteins in the human trabecular meshwork
    Michael P Fautsch
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Exp Eye Res 82:1046-52. 2006
    ..To identify myocilin interacting proteins, yeast 2-hybrid analysis was performed on >1x10(6) human trabecular meshwork cDNA clones...
  81. pmc A new insight into the cellular regulation of aqueous outflow: how trabecular meshwork endothelial cells drive a mechanism that regulates the permeability of Schlemm's canal endothelial cells
    J A Alvarado
    University of California San Francisco, Department of Ophthalmology 10 Koret Way San Francisco, CA 94143 0730, USA
    Br J Ophthalmol 89:1500-5. 2005
    To test the hypothesis that trabecular meshwork endothelial cells (TMEs) increase the permeability of Schlemm's canal endothelial cells (SCEs) by actively releasing ligands that modulate the barrier properties of SCEs.
  82. ncbi cDNA microarray analysis of gene expression changes induced by dexamethasone in cultured human trabecular meshwork cells
    Takeshi Ishibashi
    Departments of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Invest Ophthalmol Vis Sci 43:3691-7. 2002
    To profile gene expression changes induced by dexamethasone in cultured human trabecular meshwork (TM) cells and identify genes related to the occurrence of steroid-induced glaucoma.
  83. ncbi Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells
    Tomoyo Koga
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Exp Eye Res 82:362-70. 2006
    ..kinase (ROCK) in regulating activities such as adhesion, contraction and migration in cultured human trabecular meshwork (TM) cells. Human TM cells in culture were treated with Y-27632, a specific ROCK inhibitor...
  84. ncbi Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma
    Vasantha P Rao
    Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA
    BioDrugs 21:167-77. 2007
    ..data suggesting that both ROCK and Rho GTPase inhibitors can increase aqueous humor drainage through the trabecular meshwork, leading to a decrease in intraocular pressure...
  85. ncbi Multimodal nonlinear imaging of the human cornea
    Florent Aptel
    Laboratoire d Optique Appliquée, ENSTA ParisTech, Ecole Polytechnique, Palaiseau, France
    Invest Ophthalmol Vis Sci 51:2459-65. 2010
    ..combined with second-harmonic generation (SHG) and two-photon excited fluorescence (2PEF) microscopies for visualizing the microstructure of the human cornea and trabecular meshwork based on their intrinsic nonlinear properties.
  86. ncbi Oxidative stress and glaucoma: injury in the anterior segment of the eye
    S C Sacca
    Division of Ophthalmology, St Martino Hospital, Genoa, Italy
    Prog Brain Res 173:385-407. 2008
    ..Free radicals and reactive oxygen species are able to affect the cellularity of the human trabecular meshwork (HTM)...
  87. pmc Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 15:815-25. 2009
    ..Here, we investigated the mechanisms for Pro370Leu mutant myocilin to induce mitochondrial dysfunction and subsequent reactive oxygen species (ROS) generation in trabecular meshwork (TM) cells obtained from POAG individuals.
  88. ncbi Ultrastructural localization of collagen IV, fibronectin, and laminin in the trabecular meshwork of normal and glaucomatous eyes
    C R Hann
    Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minn, 55905, USA
    Ophthalmic Res 33:314-24. 2001
    ..with immunogold labeling was used to examine the ultrastructure of the basement membranes in the trabecular meshwork and to determine the presence of collagen IV, laminin, and fibronectin in 6 normal eyes and 6 eyes with ..
  89. pmc Two-photon imaging of the mouse eye
    Andrew W Johnson
    Department of Ophthalmology, University of Colorado Denver, Aurora, Colorado, USA
    Invest Ophthalmol Vis Sci 52:4098-105. 2011
    ..To image the conventional aqueous outflow pathway and adjacent structures within the intact enucleated mouse eye using a noninvasive microscopy technique...
  90. ncbi Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye d
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, New Castle, DE 19810, USA
    Fundam Clin Pharmacol 26:86-117. 2012
    ..intraocular pressure (IOP) consequent to abnormally high resistance to aqueous humor (AH) drainage via the trabecular meshwork (TM) and Schlemm's canal...
  91. pmc Dexamethasone disrupts intercellular junction formation and cytoskeleton organization in human trabecular meshwork cells
    Ye Hong Zhuo
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 16:61-71. 2010
    ..Here we investigated the effects of GCs on junctional protein expression and cytoskeleton organization in primary human trabecular meshwork (TM) cultures to understand the molecular pathologies of POAG.
  92. pmc COCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey organ cultured anterior segments
    Eun Suk Lee
    Departments of Ophthalmology and Visual Sciences, Sodaemungu Shinchondong, Seoul 120 752, Korea
    Invest Ophthalmol Vis Sci 51:2060-6. 2010
    Purpose. To determine the effects of COCH transgene expression on cultured human trabecular meshwork (HTM) cell morphology and on outflow facility (OF) in monkey organ cultured anterior segments (MOCAS). Methods...
  93. ncbi Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork
    Dorette Z Ellis
    Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32610, USA
    Invest Ophthalmol Vis Sci 50:1808-13. 2009
    ..This study investigated the role of sGC in mediating the NO-induced increases in outflow facility...
  94. ncbi Mechanobiology of trabecular meshwork cells
    Darrell WuDunn
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Eye Res 88:718-23. 2009
    b>Trabecular meshwork (TM) cells likely play a key role in regulating outflow facility and hence intraocular pressure. They function in a dynamic environment subjected to variations in mechanical and fluid shear forces...
  95. ncbi Primary trabecular meshwork cells incubated in human aqueous humor differ from cells incubated in serum supplements
    Michael P Fautsch
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 46:2848-56. 2005
    To determine whether aqueous humor, the in vivo source of nutrients for trabecular meshwork cells, alters cellular and molecular characteristics in primary trabecular monolayer cell cultures when compared with standard culture conditions.
  96. ncbi Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow
    Ponugoti Vasantha Rao
    Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
    Biol Pharm Bull 28:2189-96. 2005
    ..ticrynafen, we undertook a comparative evaluation of the dose-dependent effects of these compounds on human trabecular meshwork (HTM) cell shape, actin cytoskeletal organization, focal adhesions and transcellular fluid flow...
  97. ncbi Reconstitution of trabecular meshwork GAGs: influence of hyaluronic acid and chondroitin sulfate on flow rates
    Paul A Knepper
    Laboratory for Oculo Cerebrospinal Investigation, Division of Neurosurgery, Children s Memorial Medical Center and Department of Ophthalmology, Northwestern University Medical School, Chicago, IL, USA
    J Glaucoma 14:230-8. 2005
    ..whether the concentration of hyaluronic acid (HA) and of chondroitin sulfate (CS) occurring in the normal and the primary open-angle glaucoma (POAG) trabecular meshwork (TM) influences flow rates in vitro as a function of pressure.
  98. ncbi Trabecular meshwork alteration and intraocular pressure change following pulsed near-infrared laser trabeculoplasty in cats
    Josef Stoiber
    Bascom Palmer Eye Institute, Ophthalmic Biophysics Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmic Surg Lasers Imaging 36:471-81. 2005
    ....
  99. pmc Wnt gene expression in human trabecular meshwork cells
    Rajalekshmy Shyam
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, IL, USA
    Mol Vis 16:122-9. 2010
    ..related to the Wnt signaling pathway, such as beta-catenin (CTNNB1) and secreted frizzled-related protein-1 (sFRP1), in human trabecular meshwork (TM) cells. In addition, the effect of oxidative stress on Wnt signaling was evaluated.
  100. ncbi Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells
    Rudolf Fuchshofer
    Department of Human Anatomy, University Regensburg, Regensburg, Germany
    Invest Ophthalmol Vis Sci 47:794-801. 2006
    To determine whether cells of the cribriform trabecular meshwork (TM) express basement membrane (BM) components similar to corneoscleral TM cells and to determine whether cribriform cells are connected to the elastic tendon net of the TM.
  101. ncbi NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel
    William M Dismuke
    University of Florida, College of Pharmacy, Department of Pharmacodynamics, Gainesville, FL 32610, USA
    Am J Physiol Cell Physiol 294:C1378-86. 2008
    Nitric oxide (NO) donors decrease intraocular pressure (IOP) by increasing aqueous outflow facility in the trabecular meshwork (TM) and/or Schlemm's canal. However, the cellular mechanisms are unknown...

Research Grants65

  1. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2013
    ..The factors or mechanisms that lead to this disease are not currently understood;however, the trabecular meshwork cells play a central role in the regulation of intraocular pressure in both the normal and disease state...
  2. Cellular Senescence and Glaucoma
    Pedro Gonzalez; Fiscal Year: 2011
    ..hypothesis of this grant is that oxidative stress and the resulting increase in senescent cells in the trabecular meshwork contribute to the pathogenesis of this tissue in aging and primary open angle glaucoma...
  3. Role of trabecular meshwork contractility in modulating outflow resistance
    CHEE HIAN TAN; Fiscal Year: 2013
    ..His postdoctoral research was in trabecular meshwork and aqueous humor cell biology and physiology with respect to glaucoma...
  4. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    ..Many studies have identified oxidative damage to the trabecular meshwork (TM) cells, leading to decreased outflow facility and increased intraocular pressure...
  5. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
    ..It is our premise that KATP channel activation leads to a relaxation of the trabecular meshwork resulting in increased permeability, improved fluid flow, augmented outflow facility, and a decrease in IOP...
  6. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2012
    ..Our studies indicate that extracellular matrix (ECM) turnover within the trabecular meshwork (TM), triggered by the cytokines TNF and IL-1 is a key component of the efficacy of LTP...
  7. Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
    Douglas J Rhee; Fiscal Year: 2013
    ..Elevated intraocular pressure (IOP) is a causative risk factor and is due to altered drainage through the trabecular meshwork (TM)...
  8. Characterization of purified myocilin: glaucoma as a protein misfolding disease
    Raquel L Lieberman; Fiscal Year: 2013
    ..Glaucoma-causing mutant myocilins are poorly secreted out of human trabecular meshwork (HTM) cells to the TEM...
  9. Autophagic Lysosomal Pathway and Glaucoma
    PALOMA LITON; Fiscal Year: 2013
    ..Our preliminary data show that exposure of primary cultures of trabecular meshwork (TM) cells to chronic oxidative stress causes profound changes in the lysosomal degradative pathway, ..
  10. CYP1B1 and Retinopathy of Prematurity
    Nader Sheibani; Fiscal Year: 2010
    ..Although lack of CYP1 B1 is shown to influence the function and development of the trabecular meshwork. Its physiological role in the development of retinal vasculature and angiogenesis has not been previously ..
  11. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    ..form of glaucoma, is usually accompanied by elevated intraocular pressure (IOP) due to failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow...
  12. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2012
    ..facility caused by accumulation of extracellular matrix material (ECM) in the juxtacanicular region of the trabecular meshwork (TM). A balance normally exists between ECM deposition and degradation within the normal human TM...
  13. Magnetomotive optical coherence tomography for molecular imaging of the eye
    Jianhua Wang; Fiscal Year: 2010
    ..nano-particle- coupled antibodies will enable dynamic detection and localization of antigens in the trabecular meshwork in an animal model of glaucoma (SA 2)...
  14. Cellular Physiology of the Aqueous Outflow Pathway
    Haiyan Gong; Fiscal Year: 2013
    ..The results of this study will provide new insights for a novel therapeutic strategy to lower IOP by targeting the trabecular meshwork, where the initial problem resides.
  15. Regulation of Ocular Neural Crest and its Implications in Congenital Eye Diseases
    BRENDA LYNN BOHNSACK; Fiscal Year: 2013
    ..a transient population of stem cells that gives rise to the corneal stroma and endothelium, iris stroma, trabecular meshwork, and sclera...
  16. MicroRNA-directed modulation of intraocular pressure
    Benjamin R tenOever; Fiscal Year: 2013
    ..identified miR-200c as a strong candidate to control IOP based on its ability to inhibit contractio of trabecular meshwork cells and lower IOP in vivo...
  17. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2013
    ..of intraocular pressure (IOP) resulting from increased resistance to aqueous humor (AH) outflow through the trabecular meshwork (TM) and Schlemm's canal (SC)...
  18. Reverse Engineering of Trabecular Meshwork
    Nils A Loewen; Fiscal Year: 2013
    ..9 million. Decreased drainage through a strainer-like structure called "trabecular meshwork" is responsible for the elevated eye pressure and worsening, irreversible damage of the optic nerve...
  19. Mechanisms of anterior segment development and corneal neovascularization
    Tsutomu Kume; Fiscal Year: 2012
    ..Summary Molecular and genetic studies using mice show that neural crest-derived cells give rise to the trabecular meshwork as well as the stroma and endothelium of the cornea and are critical for the formation of the anterior ..
  20. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy K Bhattacharya; Fiscal Year: 2013
    ..are to understand the mechanisms of regulation of fluid flow through the extracellular matrix (ECM) of the trabecular meshwork (TM) and to eventually use this knowledge to develop effective therapies for preventing primary open angle ..
  21. Control of Trabecular Meshwork Cytoskeleton
    Donna M Peters; Fiscal Year: 2011
    ..with elevated levels of intraocular pressure (IOP) due to a reduction in aqueous humor outflow from the trabecular meshwork (TM)...
  22. METABOLISM OF THE TRABECULAR MESHWORK
    David L Epstein; Fiscal Year: 2011
    ..grant has focused in the past on determining the potential role of factors induced by mechanical stress in trabecular meshwork (TM) cells as modulators of Schlemm's canal (SC) endothelium permeability and overall outflow facility...
  23. Glaucoma Pathogenesis of Oculocerebrorenal syndrome of Lowe
    Yang Sun; Fiscal Year: 2013
    ..members, and (3) determine whether OCRL1 is required for the trafficking of apical membrane proteins in trabecular meshwork epithelium...
  24. Molecular mechanisms in steroid-induced glaucoma.
    John Danias; Fiscal Year: 2012
    ..Steroid-induced open angle glaucoma is caused by a decrease of trabecular meshwork (TM) outflow facility...
  25. PRESSURE REGULATION OF HUMAN TRABECULAR MESHWORK GENES
    TERESA BORRAS; Fiscal Year: 2012
    ..In humans, 90% of the aqueous humor exits the eye through the trabecular meshwork (TM). Thus, a dysfunctional TM results in increased resistance and elevated IOP...
  26. Glucocorticoids, ocular hypertension, and glaucoma
    Thomas Yorio; Fiscal Year: 2013
    ..GC-induced ocular hypertension and glaucoma is clinically similar to POAG, and GC effects on the trabecular meshwork (TM), the tissue responsible for regulating aqueous humor outflow (and therefore IOP), mimic many of the ..
  27. Restoration of Trabecular Meshwork by hMSC and Induced Pluripotent Stem Cells
    MARY JANE KELLEY; Fiscal Year: 2013
    ..Cells of the trabecular meshwork (TM) are responsible for maintaining IOP homeostasis...
  28. Mechanisms of Aqueous Humor Homeostasis -- Role of Monocytes
    Jorge A Alvarado; Fiscal Year: 2013
    Project Summary Monocytes have been shown to normally circulate through the trabecular meshwork (TM) and to be recruited in increased numbers to the TM following the application of laser irradiation...
  29. Extracellular Matrix and Outflow Resistance
    Kate E Keller; Fiscal Year: 2013
    ..Elevated IOP is caused by increased resistance to aqueous humor outflow through the trabecular meshwork (TM)...
  30. REGULATION OF OUTFLOW FACILITY BY GENE TRANSFER
    TERESA BORRAS; Fiscal Year: 2013
    ..During these past cycles we have accumulated extensive knowledge and expertise about gene transfer to the trabecular meshwork (TM)...
  31. VERTEBRATE EYE: STUDIES OF AQUEOUS OUTFLOW
    Ted S Acott; Fiscal Year: 2012
    ..An obstruction to aqueous humor outflow, primarily through the trabecular meshwork (TM), produces elevated intraocular pressure (IOP), which is the primary risk factor for glaucomatous optic ..
  32. Axonal cytoskeletal changes in experimental glaucoma
    Brad Fortune; Fiscal Year: 2012
    ..To achieve these Aims, EG will be induced via laser photocoagulation of the trabecular meshwork to cause moderate, unilateral chronic IOP elevation in 24 NHPs...
  33. The Retroject Device: A Novel Approach to Glaucoma Drug Delivery
    Molly McCarthy Walsh; Fiscal Year: 2013
    ..Therefore, there is a significant need to create alternative techniques for drug delivery directly to the trabecular meshwork and Schlemm's canal. Retroject, Inc...
  34. Aqueous Humor Outflow Control and Intraocular Pressure
    MORTIMER MORDECAI CIVAN; Fiscal Year: 2013
    ..is that: (1) conduits and regulation of ATP release may differ among Schlemm's canal (SC) and trabecular meshwork (TM) cells of the outflow pathway and ciliary epithelial cells of the inflow pathway;(2) identifying the ..
  35. Crystallin-Derived Mini-Chaperones as Protein Aggregation Inhibitors
    Krishna K Sharma; Fiscal Year: 2011
    ..In certain forms of glaucoma, the protein myocilin misfolds and aggregates in the trabecular meshwork, interfering with the outflow of aqueous humor and causing elevated intraocular pressure...
  36. Molecular Genetics of Primary Congenital Glaucoma
    Mansoor Sarfarazi; Fiscal Year: 2010
    ..Primary Congenital Glaucoma (PCG) is an inherited recessive condition with developmental defects in the trabecular meshwork (TM) and anterior segments of the eye...
  37. Ubiquitin Function In Eye Lens
    Allen Taylor; Fiscal Year: 2012
    ..This includes cornea, trabecular meshwork, retina and many cancers. PUBLIC HEALTH RELEVANCE: Sight is our most valued sense...
  38. eNOS-Dependent Mechanoregulation of Intraocular Pressure
    W Daniel Stamer; Fiscal Year: 2013
    ..Consequences of shear and NO production on SC monolayer permeability and trabecular meshwork cell contractility (and flow patterns through the trabecular meshwork) are looked at independently in aim 2 ..
  39. Targeting the Anterior Segment with Homing Peptides from Phage Display
    Donna M Peters; Fiscal Year: 2013
    ..of this grant is to use phage display libraries to identify tissue specific homing peptids for the trabecular meshwork (TM) that can be used as therapeutic delivery agents to control and lower intraocular pressure...
  40. Integrin Signaling in the Trabecular Meshwork
    Donna M Peters; Fiscal Year: 2012
    ..with elevated levels of intraocular pressure (IOP) due to a reduction in aqueous humor outflow from the trabecular meshwork (TM)...
  41. GPR119: A novel means to lower intraocular pressure?
    ALEXANDER J STRAIKER; Fiscal Year: 2012
    ..Notably, GPR119 is expressed prominently in the trabecular meshwork, responsible for outflow of aqueous humor...
  42. Cannabinoid Receptors and Novel Antiglaucoma Drugs
    Zhao Hui Song; Fiscal Year: 2010
    ..previous funding period, we have established that CB1 and CB2 cannabinoid receptors are expressed on the trabecular meshwork (TM) cells, and cannabinoid agonists enhance aqueous humor outflow through both CB1 and CB2 receptors...
  43. Identification of genes responsible for glucocorticoid-induced glaucoma
    Weiming Mao; Fiscal Year: 2013
    ..Therefore, the long-term goal of this project is to elucidate the pathways and their compo- nents in the trabecular meshwork (TM) that mediate GC-induced OHT and GIG...
  44. Prevention of RGC loss in an in vitro excitotoxic model and an in vivo model of g
    Cindy L Linn; Fiscal Year: 2012
    ..model, where 2M hypertonic saline is injected into episcleral veins to decrease the drainage through the trabecular meshwork, resulting in a slow increase in intraocular pressure, the primary risk factor associated with glaucoma...
  45. Genetics of Adult-Onset POAG
    Mary K Wirtz; Fiscal Year: 2013
    ..7 Specific Aim 3. Characterize expression of the GLC1C and GLC1G gene in the anterior segment of the eye, trabecular meshwork cells, and optic nerve of normal and glaucomatous eyes...
  46. GLYCEROLIPIDS AND PROSTAGLANDIN BIOSYNTHESIS
    ATA ABDEL LATIF; Fiscal Year: 2001
    ..activities, and the effects of various agonists on AA release and eicosanoid biosynthesis in ICB and trabecular meshwork of different mammalian species...
  47. Redefining the Model of the Blood-Aqueous Barrier
    Thomas Freddo; Fiscal Year: 2005
    ..fundamental assumptions about the biological environment surrounding the crystalline lens and within the trabecular meshwork. These changes have potential implications in the pathobiology of cataract and glaucoma...
  48. A Potential Zebrafish Model of Glaucoma by Genetic Ablation and Modification of t
    Xinping Zhao; Fiscal Year: 2009
    ..the zebrafish eye is a specialized structure that is anatomically localized in the eye where the mammalian trabecular meshwork (TM) resides...
  49. CONTROL OF CORNEAL ENDOTHELIUM DEVELOPMENT IN THE MOUSE
    Christopher Wright; Fiscal Year: 2002
    ..abnormalities, including failure of anterior chamber formation, iris dystrophy, and abnormalities of the trabecular meshwork (Kidson et al, 1999, Appendix)...
  50. ADRENERGIC & CHOLINERGIC MECHANISMS IN GLAUCOMA THERAPY
    JON POLANSKY; Fiscal Year: 1993
    ..These cell culture systems (and our prior work on human trabecular meshwork cells) appear to provide useful resources to define relevant drug responses...
  51. EXTRACELLULAR MATRIX IN GLAUCOMA
    PAUL KNEPPER; Fiscal Year: 2002
    ..indicate that POAG is associated with a marked decrease in one glycosaminoglycan, hyaluronic acid, in the trabecular meshwork. It is recognized that hyaluronic acid, even at low concentrations, has important regulatory functions in ..
  52. REGULATION OF TRABECULAR CELL GLYCOPROTEINS
    John Samples; Fiscal Year: 1991
    ..this proposal is that regulators exist which modify the production and turnover of ECM glycoproteins in the trabecular meshwork just as in many other biological systems...
  53. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 2009
    DESCRIPTION: The trabecular meshwork (TM) is a major site for regulation of the aqueous humor outflow. Cells in the TM are essential for maintenance of the normal aqueous outflow...
  54. ION AND WATER TRANSPORT IN CILIARY EPITHELIUM
    NASSER FARAHBAKHSH; Fiscal Year: 2001
    DESCRIPTION: The eye relies on the aqueous humor for nutrition of the cornea, lens, vitreous and trabecular meshwork, as well as the removal of the waste products of metabolism from these tissues...
  55. TURNOVER OF SUBSTANCES IN THE OUTFLOW PATHWAY OF THE EYE
    Arnold Miller; Fiscal Year: 1990
    ..mechanism by which aqueous outflow is regulated is not known but interactions between the cells of the trabecular meshwork, their underlying collagen beams and other extracellular substances (including glycosaminoglycans) may play ..
  56. PHOTOCHEMICAL TARGETING OF TRABECULAR MESHWORK CELLS
    Mark Latina; Fiscal Year: 1991
    ..A significant decrease in the cellularity of the trabecular meshwork (TM) has been demonstrated in POAG specimens in comparison with age-matched normals...
  57. Minimally Invasive Glaucoma Surgical Instrument
    SOHEILA MIRHASHEMI; Fiscal Year: 2003
    ..to effectively and permanently reduce IOP in glaucoma patients by atraumatically removing a 90x sector of trabecular meshwork overlaying Schlemm's canal in order to re-establish outflow of aqueous humor through the collective ..
  58. ELEMENTS IN THE TRABECULAR MESHWORK
    Thomas Richardson; Fiscal Year: 1991
    ..We propose an intensive investigation of certain of the properties of the trabecular meshwork cells, properties which are intimately involved in aqueous outflow and which could be highly influential in ..
  59. Trabecular Bypass Stent and Applicator
    GREGORY SMEDLEY; Fiscal Year: 2002
    ..Because the site of pathology is at the level of the trabecular meshwork in open angle glaucoma, incisional treatment of the trabecular meshwork is appealing...
  60. Promoters for Glaucoma Gene Therapy
    CURTIS BRANDT; Fiscal Year: 2007
    ..The pathology of glaucoma involves structures throughout the eye including the trabecular meshwork (TM), ciliary body epithelium (CE), ciliary muscle (CM), and retinal ganglion cells (RGC) providing several ..
  61. Mechanisms of Ocular Morphogenesis The anterior segment
    Randy Johnson; Fiscal Year: 2005
    ..that lmx1b is not only expressed during eye development, but is also highly expressed in the adult cornea, trabecular meshwork, and iris, suggesting that lmx1b may have important functions in these tissues...
  62. AQUEOUS HUMOR GROWTH FACTORS
    Ramesh Tripathi; Fiscal Year: 1999
    ..vitro whether specific molecules that are present in the aqueous humor stimulate the growth of cells of the trabecular meshwork and of the fibroblasts of Tenon's capsule...
  63. Signaling Role of Fibronectin in Trabecular Meshwork
    DONNA PETERS; Fiscal Year: 2005
    ..The importance of cell-matrix interactions on the trabecular meshwork (TM) and aqueous outflow, however, is not known...
  64. Tiam1/Rac1 effects on trabecular meshwork cytoskeleton
    MARIE SCHWINN; Fiscal Year: 2009
    ..These increases are believed to occur, in most cases, when the movement of aqueous humor through the trabecular meshwork (TM) of the human eye is inhibited...
  65. CYTOSKELETAL DEFECTS IN LIVING GLAUCOMA TRABECULAR CELLS
    EDWARD O BRIEN; Fiscal Year: 1999
    A deficiency in aqueous humor outflow through the trabecular meshwork (TM) underlies the increased intraocular pressure (IOP) found in primary open angle glaucoma (POAG), and is associated with an accelerated loss of endothelial cells ..