limbus corneae

Summary

Summary: An annular transitional zone, approximately 1 mm wide, between the cornea and the bulbar conjunctiva and sclera. It is highly vascular and is involved in the metabolism of the cornea. It is ophthalmologically significant in that it appears on the outer surface of the eyeball as a slight furrow, marking the line between the clear cornea and the sclera. (Dictionary of Visual Science, 3d ed)

Top Publications

  1. ncbi Limbal stem-cell therapy and long-term corneal regeneration
    Paolo Rama
    San Raffaele Scientific Institute, Ophthalmology Unit, Milan, Italy
    N Engl J Med 363:147-55. 2010
  2. ncbi Ex vivo expansion and transplantation of limbal epithelial stem cells
    Alex J Shortt
    Cells for Sight Transplantation and Research Programme, UCL Institute of Ophthalmology, London, United Kingdom
    Ophthalmology 115:1989-97. 2008
  3. ncbi Differences in the protein expression in limbal versus central human corneal epithelium--a search for stem cell markers
    Mikkel Lyngholm
    Department of Ophthalmology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark
    Exp Eye Res 87:96-105. 2008
  4. ncbi Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche
    H S Dua
    The Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, University of Nottingham, UK
    Br J Ophthalmol 89:529-32. 2005
  5. ncbi The phenotype of limbal epithelial stem cells
    Edwin C Figueira
    Inflammatory Diseases Research Unit, University of New South Wales, Australia
    Invest Ophthalmol Vis Sci 48:144-56. 2007
  6. ncbi Niche regulation of corneal epithelial stem cells at the limbus
    Wei Li
    Ocular Surface Center and TissueTech Inc Miami, Florida, 33173, USA
    Cell Res 17:26-36. 2007
  7. ncbi Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells
    Ewa Anna Blazejewska
    Department of Ophthalmology, University of Erlangen Nuremberg, Germany
    Stem Cells 27:642-52. 2009
  8. ncbi Differentially expressed genes associated with human limbal epithelial phenotypes: new molecules that potentially facilitate selection of stem cell-enriched populations
    Lili Takacs
    Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Invest Ophthalmol Vis Sci 52:1252-60. 2011
  9. ncbi Transcriptional profiling of enriched populations of stem cells versus transient amplifying cells. A comparison of limbal and corneal epithelial basal cells
    Mingyuan Zhou
    Department of Dermatology, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 281:19600-9. 2006
  10. ncbi Treatment of superior limbic keratoconjunctivitis by application of autologous serum
    E Goto
    Department of Ophthalmology, Tokyo Dental College, Ichikawa City, Chiba, Japan
    Cornea 20:807-10. 2001

Research Grants

  1. Isolation of Limbal Epithelial Stem Cells
    ROBERT LAVKER; Fiscal Year: 2003
  2. SERINE PROTEINASE INHIBITORS IN OCULAR SURFACE EPITHELIA
    ROBERT LAVKER; Fiscal Year: 2003
  3. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2004
  4. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2006
  5. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2009
  6. OCULAR SURFACE EPITHELIAL PRECURSORS
    JOSE WOLOSIN; Fiscal Year: 2007
  7. Gene Gun Technology, Opioids, and Corneal Diseases
    IAN ZAGON; Fiscal Year: 2003
  8. 4th International Research Workshop on Alopecia Areata
    ROBERT LAVKER; Fiscal Year: 2002
  9. CELL MEMBRANE DIFFERENTIATION IN CORNEAL EPITHELIUM
    JOSE WOLOSIN; Fiscal Year: 2002
  10. OCULAR SURFACE EPITHELIAL PRECURSORS
    JOSE WOLOSIN; Fiscal Year: 2009

Detail Information

Publications178 found, 100 shown here

  1. ncbi Limbal stem-cell therapy and long-term corneal regeneration
    Paolo Rama
    San Raffaele Scientific Institute, Ophthalmology Unit, Milan, Italy
    N Engl J Med 363:147-55. 2010
    ..We investigated the long-term clinical results of cell therapy in patients with burn-related corneal destruction associated with limbal stem-cell deficiency, a highly disabling ocular disease...
  2. ncbi Ex vivo expansion and transplantation of limbal epithelial stem cells
    Alex J Shortt
    Cells for Sight Transplantation and Research Programme, UCL Institute of Ophthalmology, London, United Kingdom
    Ophthalmology 115:1989-97. 2008
    ..To determine, using objective measures, the outcome of ex vivo cultured limbal epithelial stem cell (LESC) transplantation performed in compliance with good manufacturing practice using a novel culture system without 3T3 feeder cells...
  3. ncbi Differences in the protein expression in limbal versus central human corneal epithelium--a search for stem cell markers
    Mikkel Lyngholm
    Department of Ophthalmology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark
    Exp Eye Res 87:96-105. 2008
    ..SOD2 and CK15 identify clusters of limbal basal cells and therefore they may serve as markers for limbal stem cells in conjunction with the earliest transient amplifying cells...
  4. ncbi Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche
    H S Dua
    The Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, University of Nottingham, UK
    Br J Ophthalmol 89:529-32. 2005
    ..The authors undertook to re-evaluate the microanatomy of the limbus in order to identify possible sites that may represent a stem cell niche...
  5. ncbi The phenotype of limbal epithelial stem cells
    Edwin C Figueira
    Inflammatory Diseases Research Unit, University of New South Wales, Australia
    Invest Ophthalmol Vis Sci 48:144-56. 2007
    ..The purpose of this study was to identify phenotypic markers of human limbal stem cells in fetal and adult corneas...
  6. ncbi Niche regulation of corneal epithelial stem cells at the limbus
    Wei Li
    Ocular Surface Center and TissueTech Inc Miami, Florida, 33173, USA
    Cell Res 17:26-36. 2007
    ....
  7. ncbi Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells
    Ewa Anna Blazejewska
    Department of Ophthalmology, University of Erlangen Nuremberg, Germany
    Stem Cells 27:642-52. 2009
    ..Therefore, the HF may be an easily accessible alternative therapeutic source of autologous adult stem cells for replacement of the corneal epithelium and restoration of visual function in patients with ocular surface disorders...
  8. ncbi Differentially expressed genes associated with human limbal epithelial phenotypes: new molecules that potentially facilitate selection of stem cell-enriched populations
    Lili Takacs
    Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Invest Ophthalmol Vis Sci 52:1252-60. 2011
    ..The aim of this study was to identify differentially expressed genes in the human limbal epithelium by microarray analysis...
  9. ncbi Transcriptional profiling of enriched populations of stem cells versus transient amplifying cells. A comparison of limbal and corneal epithelial basal cells
    Mingyuan Zhou
    Department of Dermatology, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 281:19600-9. 2006
    ..Our findings indicate that we can obtain accurate gene expression profiles of the stem cell-enriched limbal basal cell population in their "natural" quiescent state...
  10. ncbi Treatment of superior limbic keratoconjunctivitis by application of autologous serum
    E Goto
    Department of Ophthalmology, Tokyo Dental College, Ichikawa City, Chiba, Japan
    Cornea 20:807-10. 2001
    ..The average rose bengal and fluorescein score improved ( p < 0.05), and there was subjective improvement. CONCLUSION: Autologous serum application can be used as an alternative mode of therapy in SLK...
  11. ncbi Expression of toll-like receptors in human limbal and conjunctival epithelial cells
    Jing Li
    Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Vis 13:813-22. 2007
    ..To determine the expression and function of toll-like receptors (TLRs) in human conjunctival, limbal and corneal epithelial cells...
  12. ncbi Preferential gene expression in the limbus of the vervet monkey
    Zhenhua Ding
    Cornea and Uveitis Division, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA
    Mol Vis 14:2031-41. 2008
    ..To elucidate the unique molecular factors and biological processes that are differentially expressed in the limbal stem cell microenvironment by comparing directly to that of its immediate adjacent structures, the cornea and conjunctiva...
  13. ncbi Location of corneal epithelial stem cells
    Tung Tien Sun
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Nature 463:E10-1; discussion E11. 2010
    ..We point out here that these suggestions are inconsistent with many known growth, differentiation and cell migration properties of the anterior ocular epithelia...
  14. ncbi Morphological characteristics of the limbal epithelial crypt
    Vijay A Shanmuganathan
    The Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, University of Nottingham, United Kingdom
    Br J Ophthalmol 91:514-9. 2007
    ..The purpose of this study was to further evaluate the distribution, immunophenotypical, and ultra structural characteristics of the LEC as a putative niche of stem cells...
  15. ncbi The porcine limbal epithelial stem cell niche as a new model for the study of transplanted tissue-engineered human limbal epithelial cells
    Maria Notara
    Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, United Kingdom
    Tissue Eng Part A 17:741-50. 2011
    ..These data have significant clinical value as this model can provide information on LESC fate post-transplantation and their ability to respond to injury, which is not possible to study in patients...
  16. ncbi Survival of cultured allogeneic limbal epithelial cells following corneal repair
    Justin R Sharpe
    Blond McIndoe Centre, Queen Victoria Hospital, East Grinstead, and Department of Pharmacy and Biomolecular Sciences, University of Brighton, UK
    Tissue Eng 13:123-32. 2007
    ....
  17. ncbi Tissue-regenerating, vision-restoring corneal epithelial stem cells
    Timothy Jerome Echevarria
    Inflammation and Infection Research Centre, Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, 2052, Australia
    Stem Cell Rev 7:256-68. 2011
    ..Determining where donor stem cells reside on the recipient's ocular surface and how long they remain viable will provide further insights into improving current therapeutic options for patients with LSCD...
  18. ncbi New hopes and strategies for the treatment of severe ocular surface disease
    Takahiro Nakamura
    Department of Ophthalmology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Curr Opin Ophthalmol 22:274-8. 2011
    ..This article aims to describe the recent advances and current development of ocular surface reconstruction from both basic science and clinical aspects...
  19. ncbi The spectrum of cytokeratins expressed in the adult human cornea, limbus and perilimbal conjunctiva
    Stanislava Merjava
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital and Charles University, Prague, Czech Republic
    Histol Histopathol 26:323-31. 2011
    ..The detailed characterization of the corneal, limbal and perilimbal conjunctival epithelium under normal circumstances may be useful for characterizing the changes occurring under pathological conditions...
  20. ncbi Therapeutic lamellar keratoplasty for limbal dermoids
    J A Scott
    Singapore National Eye Centre, Singapore
    Ophthalmology 108:1858-67. 2001
    ..However, improvement in refractive, astigmatic, and visual status is not guaranteed, and these procedures should be viewed more cautiously, although established good vision was maintained in our series...
  21. ncbi Amniotic membrane use in ophthalmology
    Jose A P Gomes
    Advanced Ocular Surface Center, Brazil
    Curr Opin Ophthalmol 16:233-40. 2005
    ..The purpose of this review is to describe the most recent and relevant clinical and experimental data about the use of amniotic membrane in ophthalmology...
  22. ncbi A systematic literature review of surgical interventions for limbal stem cell deficiency in humans
    Paul A Cauchi
    Department of Ophthalmology, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, United Kingdom
    Am J Ophthalmol 146:251-259. 2008
    ..To evaluate the relative benefits and to identify any adverse effects of surgical interventions for limbal stem cell deficiency (LSCD)...
  23. ncbi 13 years of cultured limbal epithelial cell therapy: a review of the outcomes
    Oliver Baylis
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK
    J Cell Biochem 112:993-1002. 2011
    ..Here, we review the outcomes of this procedure over the past 13 years with the aim of highlighting the best culture and surgical techniques to date...
  24. ncbi The role of ultrasound biomicroscopy in surgical planning for limbal dermoids
    I M Lanzl
    Glaucoma Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cornea 17:604-6. 1998
    ..Depth information is difficult to obtain by slit-lamp examination because the structure is opaque. We investigated the use of ultrasound biomicroscopic (UBM) examination for surgical planning in limbal dermoids...
  25. ncbi N-cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro
    Kazunari Higa
    Cornea Center, Tokyo Dental College, Chiba, Japan
    Invest Ophthalmol Vis Sci 50:4640-5. 2009
    ..To demonstrate the role of N-cadherin (N-cad) in maintaining the progenitor status of primary human limbal epithelial cells in vitro...
  26. ncbi Comparison of the histology, gene expression profile, and phenotype of cultured human limbal epithelial cells from different limbal regions
    Tor P Utheim
    Center for Clinical Research, Oslo University Hospital, Ulleval, University of Oslo, Oslo, Norway
    Invest Ophthalmol Vis Sci 50:5165-72. 2009
    ..To investigate whether human limbal epithelial cells (HLECs) derived from various regions of the limbus exhibit differences in gene expression and epithelial characteristics...
  27. ncbi Outcome of lamellar keratoplasty for limbal dermoids in children
    Patrick Watts
    Department of Ophthalmology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J AAPOS 6:209-15. 2002
    ..Although astigmatism was noted to decrease in a few children after excision, a significant number had an increase in astigmatism postoperatively, which warrants a close follow-up in children operated during the amblyogenic age...
  28. ncbi Cytokeratin 8 is expressed in human corneoconjunctival epithelium, particularly in limbal epithelial cells
    Stanislava Merjava
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital and First Faculty of Medicine, Charles University, Unemocnice 2, 128 08, Prague, Czech Republic
    Invest Ophthalmol Vis Sci 52:787-94. 2011
    ..The purpose of this study was to investigate the expression of cytokeratin (CK) 8 in the corneoconjunctival epithelium...
  29. ncbi Management of focal limbal stem cell deficiency associated with soft contact lens wear
    Bennie H Jeng
    Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA
    Cornea 30:18-23. 2011
    ..To present the varying manifestations of and the treatment methods for corneal epitheliopathies because of focal limbal stem cell deficiency (LSCD) associated with soft contact lens (SCL) wear...
  30. ncbi IL6 and the human limbal stem cell niche: a mediator of epithelial-stromal interaction
    Maria Notara
    Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK
    Stem Cell Res 5:188-200. 2010
    ..STAT3 and IL6 inhibition in 3.1SF cultures significantly reduced HLE colony-forming efficiency, suggesting a previously undetected STAT3-mediated involvement of IL6 in the maintenance of HLE cells in a progenitor-like state...
  31. ncbi From hair to cornea: toward the therapeutic use of hair follicle-derived stem cells in the treatment of limbal stem cell deficiency
    Ewa Anna Meyer-Blazejewska
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Stem Cells 29:57-66. 2011
    ..These data highlight the therapeutic properties of using HFSC to treat LSCD in a mouse model while demonstrating a strong translational potential and points to the niche as a key factor for determining stem cell differentiation...
  32. ncbi Effects of fibroblast origin and phenotype on the proliferative potential of limbal epithelial progenitor cells
    S Louise Ainscough
    Discipline of Medical Sciences and Vision Improvement Domain, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059, Australia
    Exp Eye Res 92:10-9. 2011
    ..Superior growth of LEPs in the presence of limbal fibroblasts indicates a role for limbal fibroblasts in promoting the proliferation of limbal epithelium during wound healing...
  33. ncbi Limbal relaxing incisions for primary mixed astigmatism and mixed astigmatism after cataract surgery
    H üseyin Bayramlar H
    Inonu University, Turgut Ozal Medical Center, Department of Ophthalmology, Malatya, Turkey
    J Cataract Refract Surg 29:723-8. 2003
    ..To evaluate the effect of limbal relaxing incisions (LRIs) in the treatment of primary mixed astigmatism and mixed astigmatism after cataract surgery...
  34. ncbi Corneal epithelial cultures generated from organ-cultured limbal tissue: factors influencing epithelial cell growth
    Eleonora Zito-Abbad
    Cornea Bank of EFS Ile de France and Department of Ophthalmology, centre hospitalier national d ophtalmologie des XV XX, Paris VI University, 28 rue de Charenton, 75012 Paris, France
    Curr Eye Res 31:391-9. 2006
    ..To explore the in vitro proliferative potential of human limbal epithelial cells after 31 degrees C organ-culture storage and to investigate putative factors influencing it...
  35. ncbi Challenges to the study of asymmetric cell division in corneal and limbal epithelia
    Federico Castro-Muñozledo
    Department of Cell Biology, Centro de Investigacion y de Estudios Avanzados del IPN, Apdo Postal 14 740, Mexico City 07000, Mexico
    Exp Eye Res 92:4-9. 2011
    ..Future studies should be oriented to understand the regulation of the asymmetrical/symmetrical division, and the control of cell fate by the niche...
  36. ncbi Full-thickness central corneal grafts in lamellar keratoscleroplasty to treat limbal dermoids
    Yun-Dun Shen
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
    Ophthalmology 112:1955. 2005
    ..Operation may markedly reduce corneal astigmatism in patients with high preoperative corneal astigmatism. Visual prognosis is good in patients undergoing surgery combined with adequate amblyopia treatment...
  37. ncbi ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells
    Cintia S de Paiva
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin St, NC 205, Houston, Texas 77030, USA
    Stem Cells 23:63-73. 2005
    ....
  38. ncbi C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells
    Vanessa Barbaro
    Epithelial Stem Cell Research Center, The Veneto Eye Bank Foundation, H SS Giovanni and Paolo, 30100 Venice, Italy
    J Cell Biol 177:1037-49. 2007
    ....
  39. ncbi Mesenchymal cells from limbal stroma of human eye
    Naresh Polisetty
    Sudhakar Sreekanth Ravi Stem Cell Biology Laboratory, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India
    Mol Vis 14:431-42. 2008
    ..In this study, we aimed to report the presence of mesenchymal cells resembling bone marrow-derived cells (MSC-BM) in the limbus of the human eye...
  40. ncbi Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures
    Hyun-Seung Kim
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, NC-205, Houston, TX 77030, USA
    Exp Eye Res 79:41-9. 2004
    ..Slow-cycling BrdU-label retaining cells, that are characteristic of stem cells, were identified in the cultures...
  41. ncbi Localization of the low-affinity nerve growth factor receptor p75 in human limbal epithelial cells
    Nick Di Girolamo
    Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, and Department of Ophthalmology, Prince of Wales Hospital, Sydney, NSW, Australia
    J Cell Mol Med 12:2799-811. 2008
    ..p75 may represent an additional ocular surface epithelial stem/progenitor cell signature gene...
  42. ncbi Different cell sizes in human limbal and central corneal basal epithelia measured by confocal microscopy and flow cytometry
    Andre C Romano
    TissueTech, Inc, and Ocular Surface Research and Education Foundation, 7000 SW 97 Avenue, Miami, Florida 33173, USA
    Invest Ophthalmol Vis Sci 44:5125-9. 2003
    ..CONCLUSIONS: The data collectively demonstrate that the smallest cells are located in the limbal basal epithelium. This feature may help isolate corneal SCs located in the limbus...
  43. ncbi Ex vivo construction of an artificial ocular surface by combination of corneal limbal epithelial cells and a compressed collagen scaffold containing keratocytes
    Shengli Mi
    School of Pharmacy, University of Reading, Reading, UK
    Tissue Eng Part A 16:2091-100. 2010
    ....
  44. ncbi The transdifferentiation potential of limbal fibroblast-like cells
    Subhadra Dravida
    Embryonic and Ocular Stem Cell Group, Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Centre, R 282, TTC Area of MIDC, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India
    Brain Res Dev Brain Res 160:239-51. 2005
    ..This multipotential capability, relatively easy isolation and high rate of ex vivo proliferation capacity make these cells a promising therapeutic tool...
  45. ncbi Comparison of characteristics of cultured limbal cells on denuded amniotic membrane and fresh conjunctival, limbal and corneal tissues
    Hossein Baharvand
    Department of Stem Cells, Royan Institute, PO Box 19395 4644, Tehran, Iran
    Dev Growth Differ 49:241-51. 2007
    ..Also, the expression of traditional SC markers may not be a reliable indicator of limbal SC and there is an increasing need to determine factor(s) involved in their stemness...
  46. ncbi Ocular regeneration by stem cells: present status and future prospects
    G Astrid Limb
    UCL Institute of Ophthalmology, 11 Bath Street, London EC1V 9EL, UK
    Br Med Bull 85:47-61. 2008
    ..Here, we discuss the current status and limitations on the application of stem cells to ocular therapies, and consider the future prospects for their use in the restoration of vision...
  47. ncbi N-Cadherin is expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche
    Ryuhei Hayashi
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Stem Cells 25:289-96. 2007
    ..These results indicate that N-cadherin may be a critical cell-to-cell adhesion molecule between corneal epithelial stem/progenitor cells and their corresponding niche cells in the limbal epithelium...
  48. ncbi Distribution of label-retaining cells in the limbal epithelium of a mouse eye
    Jin Zhao
    Department of Ophthalmology, Columbia University, New York, NY, USA
    J Histochem Cytochem 57:177-85. 2009
    ..These results show that LRCs are present asymmetrically in a narrow zone within the limbus that can be defined precisely in reference to a newly defined anatomical boundary line between the cornea and the limbus...
  49. ncbi Human corneal stem cells display functional neuronal properties
    Gail M Seigel
    Department of Ophthalmology, University at Buffalo, Buffalo, NY 14214, USA
    Mol Vis 9:159-63. 2003
    ..In this study, we tested the hypothesis that human corneal stem cells, derived from neural ectoderm, can exhibit functional neuronal properties...
  50. ncbi Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency
    S C Tseng
    Ocular Surface and Tear Center, Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Fla 33136, USA
    Arch Ophthalmol 116:431-41. 1998
    ..To examine whether amniotic membrane transplantation (AMT), in preparing the perilimbal stroma, enhances the success of allograft limbal transplantation (ALT)...
  51. ncbi Factors affecting outcome following transplantation of ex vivo expanded limbal epithelium on amniotic membrane for total limbal deficiency in rabbits
    Seng-Ei Ti
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:2584-92. 2002
    ..Furthermore, this model can be used to test the feasibility of gene therapies targeting LSCD in the future...
  52. ncbi Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces
    Satoru Yoshida
    Cornea Center and Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Invest Ophthalmol Vis Sci 47:4780-6. 2006
    ..CONCLUSIONS: Although the expression of K15 and K19 differ in humans and mice, specific staining patterns can be used to characterize the epithelial phenotype in normal and diseased ocular surface...
  53. ncbi Phenotypic analyses of limbal epithelial cell cultures derived from donor corneoscleral rims
    Z Barnard
    School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Queensland, Australia
    Clin Experiment Ophthalmol 29:138-42. 2001
    ..These findings demonstrate the potential importance of keratins 14 and 19 as markers of epithelial cell differentiation in the human cornea...
  54. ncbi Identification and characterization of limbal stem cells
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 81:247-64. 2005
    ....
  55. ncbi Autologous transplantation of conjunctival epithelial cells cultured on amniotic membrane in a rabbit model
    Kyoko Ono
    Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Mol Vis 13:1138-43. 2007
    ..To evaluate the feasibility of autologous transplantation in a rabbit model of conjunctival epithelial cells cultured on amniotic membrane for ocular surface reconstruction...
  56. ncbi Regional distribution of alpha9beta1 integrin within the limbus of the mouse ocular surface
    Ahdeah Pajoohesh-Ganji
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC, USA
    Dev Dyn 230:518-28. 2004
    ..These studies are an important step toward improving our understanding of the development and cell biology of limbal basal cells...
  57. ncbi Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions
    Hong Qi
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Vis 13:1934-41. 2007
    ..To evaluate the expression patterns of neurotrophic factors (NTFs) and their receptors in the human cornea with the intention of exploring the role of NTFs in maintaining corneal epithelial stem cells in the limbus...
  58. ncbi Loss of corneal epithelial stem cell properties in outgrowths from human limbal explants cultured on intact amniotic membrane
    Sai Kolli
    North East Stem Cell Institute, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Regen Med 3:329-42. 2008
    ..In particular, the expression of putative stem cell markers and the colony-forming efficiency of the different zones of the outgrowth were studied...
  59. ncbi Targeted cornea limbal stem/progenitor cell transfection in an organ culture model
    Bojun Zhao
    Department of Biological Sciences, Biomedical Sciences, Lancaster University, Lancaster, United Kingdom
    Invest Ophthalmol Vis Sci 49:3395-401. 2008
    ..To optimize a nonviral gene transfection system targeting the corneal limbal stem/progenitor cells...
  60. ncbi Acute wound healing in the human central corneal epithelium appears to be independent of limbal stem cell influence
    Chuan Yuan Chang
    Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Invest Ophthalmol Vis Sci 49:5279-86. 2008
    ..These migrate centripetally, differentiate outward to the surface, and are then lost by desquamation. This study was conducted to analyze the contribution of human central corneal epithelial cells toward corneal epithelial regeneration...
  61. ncbi Corneal epithelial stem cells: deficiency and regulation
    Genevieve A Secker
    Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, UCL Institute of Ophthalmology, 11 43 Bath Street, London, EC1V 9EL, UK
    Stem Cell Rev 4:159-68. 2008
    ..Developments in Biologicals 222:41-54, 2000). Studies of models of Pax6 deficiency, such as the small eyed (sey) mouse, should help to reveal the intrinsic and extrinsic mechanisms involved in normal LESC function...
  62. ncbi Corneal epithelial stem cells at the limbus: looking at some old problems from a new angle
    Robert M Lavker
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Exp Eye Res 78:433-46. 2004
    ....
  63. ncbi Minimal conjunctival limbal autograft for total limbal stem cell deficiency
    Ahmad Kheirkhah
    Ocular Surface Center, Miami, FL 33173, USA
    Cornea 27:730-3. 2008
    ..To report the results of one 60 degrees conjunctival limbal autograft (CLAU) combined with amniotic membrane (AM) transplantation for an eye with total limbal stem cell deficiency (LSCD)...
  64. ncbi Human corneal epithelial equivalents for ocular surface reconstruction in a complete serum-free culture system without unknown factors
    Seiichi Yokoo
    Departments of Corneal Tissue Regeneration, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:2438-43. 2008
    ....
  65. ncbi The effect of in vivo grown corneal epithelium transplantation on persistent epithelial defects with limbal stem cell deficiency
    Jee Taek Kim
    Department of Ophthalmology, College of Medicine, Yongsan Hospital Chung Ang University, Seoul, Korea
    J Korean Med Sci 23:502-8. 2008
    ..A corneal epithelial sheet, grown in vivo, can be transplanted to treat eye with a severe ocular surface disease, such as total limbal deficiency...
  66. ncbi The fate of limbal epithelial progenitor cells during explant culture on intact amniotic membrane
    Wei Li
    Ocular Surface Center, and TissueTech, Inc, Miami, Florida 33173, USA
    Invest Ophthalmol Vis Sci 48:605-13. 2007
    ..However, the ultimate fate of limbal epithelial progenitor cells in the explant remains unclear...
  67. ncbi [Transplantation of bioengineered corneal epithelium for the treatment of total limbal stem cell deficiency in rabbit]
    Qi Lin
    Beijing Tongren Ophthalmic Center, Capital University of Medical Sciences, Beijing 100730, China
    Zhonghua Yan Ke Za Zhi 42:679-85. 2006
    ..Fibrin gel membrane is a new bioengineered material with the characteristics of absorbability, transparence and good histological compatibility. It is supposed to be an optimum stem cell scaffold...
  68. ncbi Reconstruction of corneal epithelium with cryopreserved corneal limbal stem cells in a goat model
    Shengli Mi
    Shaanxi Branch of National Stem Cell Engineering and Technology Center, Northwest Agriculture and Forestry University, Yangling, Shaanxi Province, China
    Mol Reprod Dev 75:1607-16. 2008
    ..This study provides the first line of evidence that cryopreserved LSCs can be used for reconstruction of damaged corneas, presenting a remarkable potential source for transplantation in the treatment of corneal disorders...
  69. ncbi Epithelial stem cells of the eye surface
    R P Revoltella
    Institute of Biomedical Technologies, National Research Council of Italy, Pisa, Italy
    Cell Prolif 40:445-61. 2007
    ..With improvements in biotechnology, regenerative cornea and conjunctiva transplantation using adult epithelial stem cells becomes now a reality...
  70. ncbi Surgical treatment of limbal stem cell deficiency: are we really transplanting stem cells?
    Shigeto Shimmura
    Am J Ophthalmol 146:154-5. 2008
  71. ncbi Histopathologic limbus evolution after alkaline burns
    Jose Santiago López-García
    Ophthalmology Service, Hospital Cruz Roja, Madrid, Spain
    Cornea 26:1043-8. 2007
    ..To study the histopathologic evolution of the corneal limbus after alkaline burns according to the clinical severity and therapy used...
  72. ncbi Evaluation of therapeutic deep anterior lamellar keratoplasty in acute ocular chemical burns
    G Singh
    Guru Gobind Singh International, Eye Research and Cure Centre, New Delhi, India
    Eur J Ophthalmol 18:517-28. 2008
    ..To evaluate the role of deep anterior lamellar keratoplasty (DALK) in acute ocular chemical burns...
  73. ncbi Regeneration of squamous epithelia from stem cells of cultured grafts
    Michele De Luca
    Epithelial Stem Cell Research Center, The Veneto Eye Bank Foundation, Hospital SS Giovanni and Paolo, Venice, Italy
    Regen Med 1:45-57. 2006
    ..The procedure has been highly successful in the alleviation of suffering and the restoration of vision...
  74. ncbi Corneal epithelial stem cells: characterization, culture and transplantation
    Sajjad Ahmad
    Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle upon Tyne, Central Parkway, Newcastle upon Tyne, UK
    Regen Med 1:29-44. 2006
    ..In particular, the translation of basic science advances in LSC biology into therapeutic strategies will be highlighted...
  75. ncbi Phenotypic study after cultivated limbal epithelial transplantation for limbal stem cell deficiency
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Sugano 5 11 13, Ichikawa City, Chiba, Japan
    Arch Ophthalmol 125:1337-44. 2007
    ..To report phenotypic analysis of epithelia before and following cultivated limbal epithelial transplantation (CLET) for eyes with limbal stem cell deficiency...
  76. ncbi Stem cell therapy delivery: treading the regulatory tightrope
    Julie T Daniels
    Institute of Ophthalmology, University College London, London, UK
    Regen Med 1:715-9. 2006
    ..This may help colleagues who are developing innovative academic research-driven stem cell therapies regarding donor consent, raw materials, quality assurance, laboratory specification, indemnity and funding...
  77. ncbi Expression of Delta Np63 in response to phorbol ester in human limbal epithelial cells expanded on intact human amniotic membrane
    Elias E Hernandez Galindo
    Department of Ophthalmology, University of Essen, Essen, Germany
    Invest Ophthalmol Vis Sci 44:2959-65. 2003
    ....
  78. ncbi In vivo survival and stratification of cultured limbal epithelium
    Anees Fatima
    Clin Experiment Ophthalmol 35:96-8. 2007
    ..Herein, a case of limbal stem cell deficiency successfully managed by monolayer of cultured limbal epithelium is presented...
  79. ncbi Stepwise surgical approach for in vivo expansion of epithelial stem cells to treating severe acute chemical burns with total limbal deficiency
    Gun Sic Park
    Department of Ophthalmology, College of Medicine, Chung-Ang University, Seoul, Korea
    Korean J Ophthalmol 17:75-82. 2003
    ....
  80. ncbi Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal stem cell deficiency
    Myrna S Santos
    Cornea and External Disease Service, Department of Ophthalmology, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    Am J Ophthalmol 140:223-30. 2005
    ....
  81. ncbi Current concepts in ocular surface reconstruction
    Murat Dogru
    Tokyo Dental College, Chiba, Japan
    Semin Ophthalmol 20:75-93. 2005
    ..This review will briefly focus on the indications and methodology of each procedure and the currently available clinical data on the results of these procedures...
  82. ncbi Amniotic membrane transplantation for partial and total limbal stem cell deficiency secondary to chemical burn
    Jose Alvaro Pereira Gomes
    Cornea and External Disease Service, Department of Ophthalmology, Federal University of Sao Paulo UNIFESP, R Sabará, 566 Cjuto 212, 01239 010 São Paulo SP, Brazil
    Ophthalmology 110:466-73. 2003
    ..To evaluate the surgical outcome of preserved amniotic membrane transplantation (AMT) for ocular surface reconstruction in chemical burn with limbal stem cell deficiency...
  83. ncbi Phenotypic study of a case receiving a keratolimbal allograft and amniotic membrane for total limbal stem cell deficiency
    Edgar M Espana
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33176, USA
    Ophthalmology 110:481-6. 2003
    ..CONCLUSIONS: A normal corneal epithelial phenotype with normal basement membrane complexes was restored after a KLAL and AMT in a case with total limbal stem cell deficiency...
  84. ncbi Amniotic membrane transplantation with conjunctival limbal autograft for total limbal stem cell deficiency
    Mario A Meallet
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Ophthalmology 110:1585-92. 2003
    ....
  85. ncbi Early results of penetrating keratoplasty after cultivated limbal epithelium transplantation
    Virender S Sangwan
    Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory, Cornea and Anterior Segment Service, L V Prasad Eye Institute, Hyderabad, India
    Arch Ophthalmol 123:334-40. 2005
    ..To describe the early results of penetrating keratoplasty (PKP) in patients who had previously undergone cultivated limbal epithelium transplantation...
  86. ncbi Outcomes and DNA analysis of ex vivo expanded stem cell allograft for ocular surface reconstruction
    Sheraz M Daya
    Corneo Plastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, United Kingdom
    Ophthalmology 112:470-7. 2005
    ..To investigate the outcome of a new technique of ex vivo expanded stem cell allograft for limbal stem cell deficiency (LSCD), and to characterize the ocular surface genotype after surgery...
  87. ncbi Amniotic membrane transplantation for reconstruction of corneal epithelial surface in cases of partial limbal stem cell deficiency
    Virender S Sangwan
    Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Indian J Ophthalmol 52:281-5. 2004
    ..To assess the efficacy of amniotic membrane for treatment of partial limbal stem cell deficiency (LSCD)...
  88. ncbi Ex vivo expansion of corneal limbal epithelial/stem cells for corneal surface reconstruction
    K Ramaesh
    Princess Alexandra Eye Pavilion, Edinburgh, UK
    Eur J Ophthalmol 13:515-24. 2003
    ..This article is a chronological review of the important steps that brought ex vivo expanded stem cell transplantation in ocular, particularly corneal surface reconstruction...
  89. ncbi Donor source affects the outcome of ocular surface reconstruction in chemical or thermal burns of the cornea
    Jun Shimazaki
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Ophthalmology 111:38-44. 2004
    ..To study the association between surgical approach and postoperative results in chemical and thermal burns of the cornea...
  90. ncbi Analysis of p63 and cytokeratin expression in a cultivated limbal autograft used in the treatment of limbal stem cell deficiency
    D G Harkin
    Tissue BioRegeneration and Integration Program, Institute for Health and Biomedical Innovation, Queensland University of Technology, 2 George Street, Brisbane 4000, Australia
    Br J Ophthalmol 88:1154-8. 2004
    ..To investigate the expression of p63 and cytokeratins throughout the course of producing a cultivated autograft of limbal epithelial cells...
  91. ncbi Successful primary culture and autologous transplantation of corneal limbal epithelial cells from minimal biopsy for unilateral severe ocular surface disease
    Takahiro Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Acta Ophthalmol Scand 82:468-71. 2004
    ..We succeeded in culturing primary corneal limbal epithelial cells taken from minimal biopsy and, once grown, transplanting them on denuded amniotic membrane (AM)...
  92. ncbi Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche
    Martin Grueterich
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Surv Ophthalmol 48:631-46. 2003
    ..This review summarizes the published literature data collectively explaining how amniotic membrane is an ideal biological substrate that can help maintain and support the expansion of limbal epithelial stem cells...
  93. ncbi An investigation of removed cultivated epithelial transplants in patients after allocultivated corneal epithelial transplantation
    Leanne J Cooper
    Institute of Environmental and Natural Sciences, Lancaster University, LA1 4YQ, Lancaster, UK
    Cornea 23:235-42. 2004
    ..CONCLUSIONS: We suggest that the process of allograft rejection is responsible for the corneal epithelial loss and that this is followed by conjunctival invasion onto the amniotic membrane...
  94. ncbi Stem cell transplants in ocular surface disorders
    P R Chatterjee
    J Indian Med Assoc 101:457. 2003
  95. ncbi [Study of two immunosuppresive strategies after limbal allograft transplantation]
    I Rodríguez-Agirretxe
    Hospital Donostia, Osakidetza Servicio Vasco de Salud, San Sebastian, Espana
    Arch Soc Esp Oftalmol 78:29-34. 2003
    ..Comparison of two immunosuppressive strategies after limbal allograft transplantation in an experimental model of ocular surface chemical burn...
  96. ncbi Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal stem cell deficiency
    Murat Dogru
    Am J Ophthalmol 140:305-6. 2005
  97. ncbi [Amniotic membrane transplantation in severe corneal epithelial diseases. Preliminary results]
    E Zito
    , Centre Hospitalier National d'Ophtalmologie des XV-XX, 28, rue de Charenton, 75571 Paris Cedex 12, France
    J Fr Ophtalmol 25:879-88. 2002
    ..CONCLUSION: AMT is a useful technique for ocular surface reconstruction, especially in association with limbal transplantation. It could also improve the prognosis of penetrating keratoplasty in patients with severe corneal conditions...
  98. ncbi Nonpreserved human amniotic membrane transplantation in acute and chronic chemical eye injuries
    Omür O Uçakhan
    Department of Ophthalmology, Ankara University School of Medicine, Cinnah Caddesi 9 7, Cankaya 06680, Ankara, Turkey
    Cornea 21:169-72. 2002
    ..To evaluate the safety and efficacy of nonpreserved amniotic membrane transplantation (AMT) with or without limbal autograft transplantation (LAT) in management of acute and chronic chemical eye injuries...
  99. ncbi Changes observed in keratolimbal allograft
    Fumiko Maruyama-Hosoi
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Cornea 25:377-82. 2006
    ..CONCLUSIONS: Presumed limbal graft rejection occurred in approximately 13% of cases after KLAL. Suppression of the immune reaction remains a key to success in KLAL...
  100. ncbi Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders
    Jun Shimazaki
    Department of Ophthalmology, Tokyo Dental College, 5-11-13 Sugano, Ichikawa-shi, Chiba 272-8513, Japan
    Ophthalmology 109:1285-90. 2002
    ....
  101. ncbi Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal stem cell deficiency
    Vikas Mittal
    Am J Ophthalmol 141:599-600; author reply 600. 2006

Research Grants68

  1. Isolation of Limbal Epithelial Stem Cells
    ROBERT LAVKER; Fiscal Year: 2003
    ....
  2. SERINE PROTEINASE INHIBITORS IN OCULAR SURFACE EPITHELIA
    ROBERT LAVKER; Fiscal Year: 2003
    ..These studies will serve as a baseline for future studies on the therapeutic use of PAI-2 in ophthalmology. ..
  3. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2004
    ..g. persistent corneal epithelial breakdown), as well as neoplastic transformations giving rise to the unusually aggressive mucoepidermoid and sebaceous carcinomas. ..
  4. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2006
    ..g., persistent corneal epithelial breakdown, as well as neoplastic transformations giving rise ocular epithelial tumors). ..
  5. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2009
    ..g., persistent corneal epithelial breakdown, as well as neoplastic transformations giving rise ocular epithelial tumors). ..
  6. OCULAR SURFACE EPITHELIAL PRECURSORS
    JOSE WOLOSIN; Fiscal Year: 2007
    ..Completion of these initial studies will provide critical new information on the features of the ocular precursor cell pool. ..
  7. Gene Gun Technology, Opioids, and Corneal Diseases
    IAN ZAGON; Fiscal Year: 2003
    ..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
  8. 4th International Research Workshop on Alopecia Areata
    ROBERT LAVKER; Fiscal Year: 2002
    ..Integration of the latest research findings with new AA therapies on the horizon will sum up the formal presentations. The evening session will be a poster discussion session in which new work will be presented. ..
  9. CELL MEMBRANE DIFFERENTIATION IN CORNEAL EPITHELIUM
    JOSE WOLOSIN; Fiscal Year: 2002
    ..abstract_text> ..
  10. OCULAR SURFACE EPITHELIAL PRECURSORS
    JOSE WOLOSIN; Fiscal Year: 2009
    ..Completion of these initial studies will provide critical new information on the features of the ocular precursor cell pool. ..
  11. ADHESION MOLECULES AND EPIDERMAL STRATIFICATION
    ROBERT LAVKER; Fiscal Year: 2001
    ....
  12. OCULAR SURFACE STEM CELL GENES
    JOSE WOLOSIN; Fiscal Year: 2006
    ..Given our current very limited understanding of stem cells, acquisition of a gene library is an essential, high impact step in the long path to unravel the process underlying the functionality of these privileged cells. ..
  13. Naltrexone as a Novel Treatment for Diabetic Keratopathy
    IAN ZAGON; Fiscal Year: 2007
    ..The proposed use of biotherapy with NTX is an innovative approach whereby the patient's own growth regulatory mechanisms are manipulated to correct complications from diabetes. ..
  14. MicroRNAs and Corneal Epithelial Stem Cells
    ROBERT LAVKER; Fiscal Year: 2007
    ..Since miRNAs can function to prevent cell division, their identification and potential pharmacologic downregulation could be useful in promoting corneal epithelial wound repair. ..
  15. The Role of MicroRNAs in Corneal Epithelial Homeostasis
    Robert M Lavker; Fiscal Year: 2010
    ....
  16. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2009
    ..g., persistent corneal epithelial breakdown, as well as neoplastic transformations giving rise ocular epithelial tumors). ..
  17. CORNEAL EPITHELIAL STEM CELLS
    Robert M Lavker; Fiscal Year: 2010
    ..g., persistent corneal epithelial breakdown, as well as neoplastic transformations giving rise ocular epithelial tumors). ..
  18. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 2000
    ..These studies should ultimately lead to a better understanding and therapy of ocular surface disorders including persistent corneal epithelial defect and various dry-eye conditions. ..
  19. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 1993
    ..This will ultimately increase our knowledge on diseases of the ocular surface epithelia such as persistent corneal epithelial defect and the various dry- eye conditions...
  20. CORNEAL EPITHELIAL STEM CELLS
    ROBERT LAVKER; Fiscal Year: 1990
    ..This will ultimately increase our knowledge on the structure and function of corneal and limbal epithelia in man...
  21. Notch Signaling in the Corneal Epithelium
    Ali Djalilian; Fiscal Year: 2007
    ..These results will lead to the development of new treatments for patients with disabling visual conditions involving the surface of the eye. ..
  22. NICHE REGULATION OF LIMBAL STEM CELLS
    Scheffer C G Tseng; Fiscal Year: 2010
    ....
  23. NICHE REGULATION OF LIMBAL STEM CELLS
    Scheffer Tseng; Fiscal Year: 2007
    ....
  24. GROWTH AND DIFFERNTIATION OF OCULAR SURFACE EPITHELIA
    Scheffer Tseng; Fiscal Year: 1993
    ..Using the resistance of the SC but not the TAC to tumor-promoter (TPA) treatment, the two cells lines will be differentiated with respect to the mitogenic pathway mediated by protein kinase C...
  25. NEUROTROPHIC FACTOR MODULATION OF CORNEAL ENDOTHELIUM
    Shay Whey Koh; Fiscal Year: 2009
    ..abstract_text> ..
  26. Gene Delivery to the Trabecular Meshwork
    Douglas Rhee; Fiscal Year: 2004
    ..These studies would set the foundation for future evaluations of the function of MIF in the TM and MIF?s potential as a candidate for gene therapy for the treatment of glaucoma. ..
  27. O-Glycans on Mucins at the Ocular Surface
    PABLO ARGUESO; Fiscal Year: 2007
    ..aeruginosa to the O-linked carbohydrates of individual mucins collected from tears. B. Determine in vitro how inhibition of O-glycan synthesis on membrane-associated mucins affects P. aeruginosa adherence to corneal cells. ..