middle ear

Summary

Top Publications

  1. pmc Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
    Joseph Jurcisek
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 73:3210-8. 2005
  2. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
  3. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
  4. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
  5. ncbi Middle ear pressure regulation--complementary active actions of the mastoid and the Eustachian tube
    Michael Gaihede
    Department of Otolaryngology Head and Neck Surgery, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Otol Neurotol 31:603-11. 2010
  6. ncbi Characterization of a temperature-sensitive mouse middle ear epithelial cell line
    Katsuyuki Tsuchiya
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Acta Otolaryngol 125:823-9. 2005
  7. ncbi Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium
    M Mallo
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Development 127:4127-36. 2000
  8. ncbi High frequency of Alloiococcus otitidis in the nasopharynx and in the middle ear cavity of otitis-prone children
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Pediatr Otorhinolaryngol 70:1009-14. 2006
  9. ncbi Tetrapod-like middle ear architecture in a Devonian fish
    Martin D Brazeau
    Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Evolutionary Biology Centre, Uppsala University, Norbyv 18A, SE 752 36 Uppsala, Sweden
    Nature 439:318-21. 2006
  10. ncbi Evolutionary development of the middle ear in Mesozoic therian mammals
    Qiang Ji
    Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China
    Science 326:278-81. 2009

Detail Information

Publications255 found, 100 shown here

  1. pmc Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
    Joseph Jurcisek
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 73:3210-8. 2005
    ..NTHI forms biofilms in vitro as well as in the chinchilla middle ear, suggesting that biofilm formation in vivo might play an important role in the pathogenesis and chronicity of OM...
  2. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
    ..Our data demonstrated that CYLD is induced by NTHi in the middle ear and lung of mice...
  3. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
    ..N-acetyl-neuraminic) acid promotes biofilm formation by NTHi in vitro and bacterial persistence within the middle ear or lung in vivo...
  4. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
    Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains...
  5. ncbi Middle ear pressure regulation--complementary active actions of the mastoid and the Eustachian tube
    Michael Gaihede
    Department of Otolaryngology Head and Neck Surgery, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Otol Neurotol 31:603-11. 2010
    b>Middle ear pressure (MEP) is actively regulated by both the Eustachian tube and the mastoid air cell system.
  6. ncbi Characterization of a temperature-sensitive mouse middle ear epithelial cell line
    Katsuyuki Tsuchiya
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Acta Otolaryngol 125:823-9. 2005
    Temperature-sensitive mouse middle ear epithelial cells have been successfully established and characterized.
  7. ncbi Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium
    M Mallo
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Development 127:4127-36. 2000
    ..Vibrations in this membrane are then transduced into the inner ear by the ossicle chain of the middle ear, composed of the malleus, incus and stapes...
  8. ncbi High frequency of Alloiococcus otitidis in the nasopharynx and in the middle ear cavity of otitis-prone children
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Pediatr Otorhinolaryngol 70:1009-14. 2006
    Colonization of middle ear pathogens is facilitated in the nasopharynx of otitis-prone children, and is associated with the development of otitis media...
  9. ncbi Tetrapod-like middle ear architecture in a Devonian fish
    Martin D Brazeau
    Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Evolutionary Biology Centre, Uppsala University, Norbyv 18A, SE 752 36 Uppsala, Sweden
    Nature 439:318-21. 2006
    ..in the remodelling of the spiracular tract and suspensorium (jaw suspension) of osteolepiform fishes into the middle ear of tetrapods have remained elusive...
  10. ncbi Evolutionary development of the middle ear in Mesozoic therian mammals
    Qiang Ji
    Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China
    Science 326:278-81. 2009
    The definitive mammalian middle ear (DMME) is defined by the loss of embryonic Meckel's cartilage and disconnection of the middle ear from the mandible in adults...
  11. ncbi Evidence of local antibody response against Alloiococcus otitidis in the middle ear cavity of children with otitis media
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    FEMS Immunol Med Microbiol 49:41-5. 2007
    ..otitidis has a pathogenic role and induces local immune response in the middle ear as a true pathogen. Whole bacterial sonicate of A...
  12. ncbi Comparison of the antiemetic effects of ondansetron and dexamethasone on middle ear surgery
    Berrin Isik
    Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Bsevler, Ankara, Turkey
    Saudi Med J 27:646-51. 2006
    To compare the antiemetic efficacy of ondansetron and dexamethasone in adults undergoing middle ear surgery.
  13. ncbi Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusion
    Yasuhiro Tsuboi
    Department of Otolaryngology, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, USA
    Acta Otolaryngol 122:153-60. 2002
    Otitis media with mucoid effusion, characterized by mucous cell metaplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a common otological disease that frequently affects young children...
  14. pmc Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants
    Marisol A Figueira
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Room 508, 774 Albany Street, Boston Medical Center, Boston, MA 02118, USA
    Infect Immun 75:325-33. 2007
    ..influenzae strains, which in turn may impact their virulence. These data demonstrate a central role for complement in innate immune defenses against NT H. influenzae infections and specifically EOM...
  15. pmc Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:87. 2008
    ..We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear.
  16. ncbi Randomized, double-blind, placebo-controlled, dosed-finding study of the antiemetic effects and tolerability of ramosetron in adults undergoing middle ear surgery
    Yoshitaka Fujii
    Department of Anesthesiology, Toride Kyodo General Hospital, Toride, Japan
    Clin Ther 25:3100-8. 2003
    ..another SSRA, in preventing emetic symptoms in adults in the first 48 hours after the start of anesthesia for middle ear surgery...
  17. ncbi Demonstration of nasopharyngeal and middle ear mucosal biofilms in an animal model of acute otitis media
    Michael Hoa
    Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Otol Rhinol Laryngol 118:292-8. 2009
    We performed this study to determine the role of nasopharyngeal and middle ear (ME) biofilms in acute otitis media (AOM).
  18. ncbi Streptococcus pneumoniae forms surface-attached communities in the middle ear of experimentally infected chinchillas
    Sean D Reid
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Infect Dis 199:786-94. 2009
    ..Streptococcus pneumoniae (pneumococcus) causes respiratory and systemic infections that are a major public health problem worldwide. It has been postulated that pneumococci persist in vivo in biofilm communities...
  19. pmc Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media
    Masayuki Furukawa
    Department of Surgery, UCSD School of Medicine, Fir Bldg, Rm 106, 9500 Gilman Dr 0666, La Jolla, CA 92037, USA
    Infect Immun 75:2562-71. 2007
    ..the participation of signaling via the Jun N-terminal protein kinase (JNK) mitogen-activated protein kinase in middle ear mucosal hyperplasia in animal models of bacterial otitis media...
  20. pmc Hag directly mediates the adherence of Moraxella catarrhalis to human middle ear cells
    Brian Bullard
    Department of Medical Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Ave, Health Education Bldg, Rm 267, Toledo, OH 43614, USA
    Infect Immun 73:5127-36. 2005
    ..with a spectinomycin resistance cassette, and the binding of isogenic mutants to primary cultures of human middle ear epithelial cells (HMEE), as well as A549 pneumocytes, was measured...
  21. pmc Clinically applicable multiplex PCR for four middle ear pathogens
    P H Hendolin
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Clin Microbiol 38:125-32. 2000
    ..H. Hendolin, A. Markkanen, J. Ylikoski, and J. J. Wahlfors, J. Clin. Microbiol. 35:2854-2858, 1997) in middle ear effusions (MEEs) was modified to be better suited for clinical use...
  22. ncbi Prophylactic antiemetic effect of midazolam after middle ear surgery
    Jae Sik Jung
    Department of Anesthesiology, Kyungpook National University Hospital, Jung Gu, Daegu, Republic of Korea
    Otolaryngol Head Neck Surg 137:753-6. 2007
    To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
  23. ncbi Middle ear and cochlear disorders result in different DPOAE growth behaviour: implications for the differentiation of sound conductive and cochlear hearing loss
    Daniel D Gehr
    ENT Department, Technische Universitat Munchen, Clinic rechts der Isar, Ismaninger Strasse 22, D 81675 Munich, Germany
    Hear Res 193:9-19. 2004
    ..With an inner ear dysfunction a steeper I/O-function is observed. Due to the linear sound processing of the middle ear, one can assume that the DPOAE growth behaviour remains unaltered with a sound conduction dysfunction...
  24. ncbi Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Int J Pediatr Otorhinolaryngol 73:677-80. 2009
    ..In the middle ear, proinflammatory cytokines and chemokines are released in association with infection by pathogens, and these ..
  25. ncbi Middle ear and mastoid glomus tumors (glomus tympanicum): an algorithm for the surgical management
    Mario Sanna
    Gruppo Otologico, Piacenza Rome, Italy
    Auris Nasus Larynx 37:661-8. 2010
    Glomus tumors are slow-growing benign lesions and represent the most common primary neoplasms of the middle ear. The objective of the present study is to report our surgical strategy in the management of glomus tympanicum tumors.
  26. ncbi Magnetic resonance imaging of the mastoid cavity and middle ear: prevalence and clinical significance of incidental abnormal findings in a nonotolaryngologic adult and pediatric population
    Dong Hee Lee
    Department of Otolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Otolaryngol 35:13-8. 2006
    The purposes of this study were to determine the prevalence of abnormalities in the mastoid cavity and middle ear in a nonotolaryngologic population and to correlate the results with clinical data.
  27. ncbi Multiple osteomas in the middle ear
    Chang Woo Kim
    Department of Otorhinolaryngology Head and Neck Surgery, Hallym University College of Medicine, 445 Gil Dong, Gangdong gu, Seoul 134 701, Korea
    Eur Arch Otorhinolaryngol 263:1151-4. 2006
    Osteomas in the middle ear are extremely rare and are generally solitary and small...
  28. ncbi On the physics of the infant feeding bottle and middle ear sequela: ear disease in infants can be associated with bottle feeding
    C E Brown
    Mt Zion Family Care Center, Southern Illinois University School of Medicine, 1200 North State Highway 121, Mt Zion, IL 62549 USA
    Int J Pediatr Otorhinolaryngol 54:13-20. 2000
    ..The negative pressure inside the bottle causes the infant to suck excessively and the intraoral negative pressure may subsequently be transmitted to the middle ear via the eustachian tube.
  29. ncbi Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear
    Ming Yang Lee
    Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center, Tainan, Taiwan
    J Craniofac Surg 17:797-800. 2006
    ..GCT of the right petrous temporal bone extending into the contiguous middle cranial fossa, infratemporal space, middle ear and external ear canal...
  30. ncbi Changes of oral trigeminal sensitivity in patients after middle ear surgery
    Tino Just
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, Germany
    Laryngoscope 117:1636-40. 2007
    ..The specific aim of this study was to re-investigate the effect of chorda tympani damage on both trigeminal sensitivity and taste ability...
  31. ncbi Otoendoscopy in cholesteatoma surgery of the middle ear: what benefits can be expected?
    Stephane Ayache
    ORPAC ENT Department Face and Neck Surgery Clinique du Palais, Grasse, France www orpac grasse com
    Otol Neurotol 29:1085-90. 2008
    This study was conducted with the aim of determining the contribution of otoendoscopy in the surgical management of cholesteatoma of the middle ear.
  32. ncbi Antiemetic efficacy of dexamethasone combined with midazolam after middle ear surgery
    Jinseok Yeo
    Department of Anesthesiology, Kyungpook National University Hospital, Daegue, Republic of Korea
    Otolaryngol Head Neck Surg 141:684-8. 2009
    To evaluate the antiemetic efficacy of dexamethasone combined with midazolam after middle ear surgery.
  33. ncbi Facial canal anatomy in patients with mandibulofacial dysostosis: comparison with respect to the severities of microtia and middle ear deformity
    Hideki Takegoshi
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Otol Neurotol 26:803-8. 2005
    To study the difference in the facial canal anatomy in terms of the severity of microtia and deformity of the middle ear in patients with mandibulofacial dysostosis using high-resolution computed tomography.
  34. ncbi Retinoic acid disturbs mouse middle ear development in a stage-dependent fashion
    M Mallo
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Biol 184:175-86. 1997
    The mammalian middle ear contains a chain of three ossicles, the malleus, incus, and stapes, that transmit into the inner ear the vibrations produced in the tympanic membrane by aerial sound...
  35. ncbi Middle ear structure and bone conduction in Spalax, Eospalax, and Tachyoryctes mole-rats (Rodentia: Spalacidae)
    Matthew J Mason
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Morphol 271:462-72. 2010
    ....
  36. ncbi Minimally invasive, image-guided, facial-recess approach to the middle ear: demonstration of the concept of percutaneous cochlear access in vitro
    Robert F Labadie
    Department of Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8605, USA
    Otol Neurotol 26:557-62. 2005
    Image-guided surgery will permit accurate access to the middle ear via the facial recess using a single drill hole from the lateral aspect of the mastoid cortex.
  37. ncbi Acoustic responses of the human middle ear
    S E Voss
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 150:43-69. 2000
    Measurements on human cadaver ears are reported that describe sound transmission through the middle ear. Four response variables were measured with acoustic stimulation at the tympanic membrane: stapes velocity, middle-ear cavity sound ..
  38. pmc Partial characterization of normal and Haemophilus influenzae-infected mucosal complementary DNA libraries in chinchilla middle ear mucosa
    Joseph E Kerschner
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Ann Otol Rhinol Laryngol 119:270-8. 2010
    We sought to construct and partially characterize complementary DNA (cDNA) libraries prepared from the middle ear mucosa (MEM) of chinchillas to better understand pathogenic aspects of infection and inflammation, particularly with respect ..
  39. ncbi Role of transtympanic endoscopy of the middle ear in the diagnosis of perilymphatic fistula in patients with sensorineural hearing loss or vertigo
    Z Selmani
    Department of Otolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    ORL J Otorhinolaryngol Relat Spec 64:301-6. 2002
    The diagnosis of perilymphatic fistula (PLF) is often difficult, and therefore the condition can be overlooked. Tympanoscopy presents an alternative procedure for visualising the middle ear anatomy, and it may help to diagnose PLF.
  40. ncbi Virtual endoscopy of the middle ear: experimental and clinical results of a standardised approach using multi-slice helical computed tomography
    Thomas Rodt
    Department of Neuroradiology, Medical School Hannover, Carl Neuberg Strasse 1, Germany
    Eur Radiol 12:1684-92. 2002
    Virtual endoscopy (VE) enables non-invasive 3D endoluminal imaging of the middle ear by post-processing of CT data. To optimise the clinical application a standardised approach was evaluated in normal and pathologic cases...
  41. ncbi Genotyping of Streptococcus pneumoniae and Haemophilus influenzae isolated from paired middle ear fluid and nasopharynx by pulsed-field gel electrophoresis
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama Shi, Wakayama, Japan
    ORL J Otorhinolaryngol Relat Spec 66:233-40. 2004
    ..isolates of Streptococcus pneumoniae and 30 isolates of Haemophilus influenzae from paired nasopharynx and middle ear fluids of 21 children with acute otitis media (AOM) were evaluated to determine genotypes by polymerase chain ..
  42. ncbi Selective expression of aquaporin 1, 4 and 5 in the rat middle ear
    S Minami
    Department of Pharmacology, Miyazaki Medical College, Kiyotake, Japan
    Hear Res 158:51-6. 2001
    The middle ear cavity is an air-filled space that must be maintained for effective sound transmission to the inner ear...
  43. ncbi The human anterior tympanic artery. A nutrient artery of the middle ear with highly variable origin
    R Wasicky
    Department 2, Institute of Anatomy, University of Vienna, Austria
    Cells Tissues Organs 166:388-94. 2000
    ..the deep auricular, middle, and accessory meningeal, as well as the posterior deep temporal, inferior alveolar and masseteric arteries were found to form common trunks with the anterior tympanic artery...
  44. ncbi Computer-integrated finite element modeling of human middle ear
    Q Sun
    School of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Avenue, Room 200, Norman, OK 73019, USA
    Biomech Model Mechanobiol 1:109-22. 2002
    The objective of this study was to produce an improved finite element (FE) model of the human middle ear and to compare the model with human data...
  45. ncbi Detection of mucin gene expression in normal rat middle ear mucosa by reverse transcriptase-polymerase chain reaction
    Y P Chen
    Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus 43210-1282, USA
    Acta Otolaryngol 121:45-51. 2001
    ..The mechanisms controlling mucin secretion in the middle ear are not completely understood...
  46. ncbi Virtual CT otoscopy of the middle ear and ossicles in dogs
    Kidong Eom
    College of Veterinary Medicine, Konkuk University, Veterinary Diagnostic Imaging
    Vet Radiol Ultrasound 49:545-50. 2008
    Virtual otoscopy enables noninvasive 3D endoluminal imaging of the middle ear through postprocessing of computed tompgraphy (CT) data...
  47. ncbi ENaC- and CFTR-dependent ion and fluid transport in human middle ear epithelial cells
    Jae Young Choi
    Department of Otorhinolaryngology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu Seoul, 120 752, Republic of Korea
    Hear Res 211:26-32. 2006
    Ion channels, such as the epithelial sodium channel (ENaC), are essential for maintaining a fluid-free middle ear cavity by controlling periciliary fluid...
  48. ncbi Virtual endoscopy imaging of the middle ear cavity and ossicles
    T S Karhuketo
    Department of Otorhinolaryngology, Tampere University Hospital, Finland
    Eur Arch Otorhinolaryngol 259:77-83. 2002
    ..Virtual endoscopic images were produced with separate, commercially available software, paying attention to the middle ear cavity and ossicles...
  49. ncbi In vitro reconstruction of a three-dimensional middle ear mucosal organ and its in vivo transplantation
    Kota Wada
    Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 126:801-10. 2006
    These experimental findings suggest the feasibility of artificial middle ear mucosa grafting as an effective treatment for achieving mucosal regeneration after middle ear surgery.
  50. ncbi Squamous cell carcinoma of the external auditory canal and middle ear: an operation combined with preoperative chemoradiotherapy and a free surgical margin
    Takashi Nakagawa
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Otol Neurotol 27:242-8; discussion 249. 2006
    ..Treatment outcomes for squamous cell carcinoma of the temporal bone were evaluated regarding stage, therapeutic strategy, and prognostic factors...
  51. ncbi Difference in facial canal anatomy in terms of severity of microtia and deformity of middle ear in patients with microtia
    Hideki Takegoshi
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Laryngoscope 113:635-9. 2003
    To study the difference in the facial canal anatomy in terms of the severity of microtia and deformity of the middle ear in patients with microtia using high-resolution computed tomography (HRCT).
  52. ncbi Measurements of human middle ear forward and reverse acoustics: implications for otoacoustic emissions
    Sunil Puria
    Stanford University, Mechanics and Computation Division, Palo Alto, California 94305, USA
    J Acoust Soc Am 113:2773-89. 2003
    ..These measurements can be used to fully characterize the middle ear as a two-port system...
  53. ncbi Radiopaque contrast dye in nasopharynx reaches the middle ear during swallowing and/or yawning
    B Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville 22908, USA
    Acta Otolaryngol 125:625-8. 2005
    Contrast dye in the nasopharynx reaches the middle ear during swallowing and yawning in normal adults. This suggests that displacement of bacteria in nasopharyngeal secretion to the middle ear may occur frequently during sleep.
  54. ncbi Signaling pathways in interleukin-1beta-mediated middle ear mucin secretion
    Joseph E Kerschner
    Division of Pediatric Otolaryngology and the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Laryngoscope 116:207-11. 2006
    ..protein kinase C (PKC), and nitric oxide synthase (NOS) pathways during upregulation of mucin secretion by middle ear epithelium after exposure to interleukin-1beta and to examine the ability of a specific interleukin-1 receptor ..
  55. ncbi Central auditory pathways mediating the rat middle ear muscle reflexes
    Daniel J Lee
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:358-69. 2006
    The middle ear muscle (MEM) reflexes function to protect the inner ear from intense acoustic stimuli and to reduce acoustic masking. Sound presented to the same side or to the opposite side activates the MEM reflex on both sides...
  56. ncbi An advanced computer-aided geometric modeling and fabrication method for human middle ear
    Qunli Sun
    School of Aerospace and Mechanical Engineering, University of Oklahoma, 865 Asp Avenue, Room 201, Norman, OK 73019, USA
    Med Eng Phys 24:595-606. 2002
    ..a practical and systematic method for reconstructing accurate computer and physical models of the entire human middle ear. The proposed method starts with the histological section preparation of human temporal bone...
  57. ncbi Inflammatory pseudotumor of the middle ear masquerading as Bell's palsy
    Richard G Lee
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH, USA
    Am J Otolaryngol 28:423-6. 2007
    ..Therefore, the relationship between an IPT and facial nerve paralysis is vital and must be recognized for treatment and to maximize postoperative facial nerve function...
  58. ncbi Current use of implants in middle ear surgery
    R A Goldenberg
    Department of Otolaryngology, Wright State University School of Medicine, Dayton, Ohio, USA
    Otol Neurotol 22:145-52. 2001
    ..Of the 575 questionnaires mailed, 274 (47%) were returned. Only 248 of the respondents performed middle ear surgery (43%), and their responses constitute the database for this study...
  59. ncbi Middle ear impedance measurements in large vestibular aqueduct syndrome
    Cem Bilgen
    Ege University, Medical School, Department of Otorhinolaryngology, Izmir, Turkey
    Auris Nasus Larynx 36:263-8. 2009
    To assess the effect of inner ear pressure on middle ear impedance in patients with large vestibular aqueduct syndrome (LVAS).
  60. ncbi Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma
    Y Iino
    Department of Otolaryngology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Clin Exp Allergy 31:1135-43. 2001
    ..with intractable otitis media associated with bronchial asthma have extensive accumulation of eosinophils in the middle ear mucosa and middle ear effusion, systematic histological and immunohistochemical studies have not been performed.
  61. ncbi Comparison of the efficacy of propofol and metoclopramide in preventing postoperative nausea and vomiting after middle ear surgery
    Yusuf Unal
    Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey
    Saudi Med J 30:778-82. 2009
    To compare the administration of sub hypnotic dose of propofol with metoclopramide and placebo in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery.
  62. pmc The mastoid as a functional rate-limiter of middle ear pressure change
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, 3000 Mt Royal Blvd, Glenshaw, PA 15116, USA
    Int J Pediatr Otorhinolaryngol 71:393-402. 2007
    The physiological function of the mastoid air cell system (MACS) with respect to middle ear (ME) pressure-regulation remains controversial because predictive mathematical models and experimental data to formulate and test hypotheses are ..
  63. ncbi The prevalence and significance of incidental middle ear and mastoid cavity abnormalities on MRI in a pediatric population
    Ali Balci
    Mustafa Kemal University, Faculty of Medicine, Department of Radiology, Antakya 31100, Hatay, Turkey
    Int J Pediatr Otorhinolaryngol 72:1849-54. 2008
    The purposes of this study were to determine the prevalence of abnormalities in the middle ear and mastoid cavity on the magnetic resonance imaging (MRI) in children and correlate the results with clinical data, tympanometric findings and ..
  64. ncbi Middle ear barotrauma with hyperbaric oxygen therapy: incidence and the predictive value of the nine-step inflation/deflation test and otoscopy
    Serdar Karahatay
    Department of Otorhinolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, Ankara, Turkey
    Ear Nose Throat J 87:684-8. 2008
    We conducted a prospective study to determine the incidence of middle ear barotrauma in patients who were undergoing hyperbaric oxygen therapy (HBOT)...
  65. ncbi In vivo adenoviral transduction of the neonatal rat cochlea and middle ear
    S Dazert
    Department of Otolaryngology-Head and Neck Surgery, , , Germany
    Hear Res 151:30-40. 2001
    ..AdV) vector was used for gene transfer of a beta-galactosidase (beta-gal) reporter gene to the neonatal middle ear and cochlea of 5 day old rats...
  66. ncbi Laser Doppler vibrometry of the middle ear in humans: derivation dependence, variability, and bilateral differences
    Irina Arechvo
    Department of Ear, Nose, and Throat Diseases, Vilnius University Emergency Hospital, Vilnius, Lithuania
    Medicina (Kaunas) 45:878-86. 2009
    ..Derivation dependence, inter- and intrasubject/intertest variability, bilateral differences of the eardrum vibration characteristics have been investigated using laser Doppler vibrometry (LDV)...
  67. ncbi Anomalous vessel in the middle ear: the role of CT and MR angiography
    J G Caldas
    Department of Radiology, , , Brazil
    Neuroradiology 40:748-51. 1998
    ..These investigations, coupled with knowledge of the embryological development allowed a diagnosis of a complex vascular anomaly in the middle ear and avoided potential surgical complications.
  68. ncbi A huge osteoma of the middle ear
    Yang Sun Cho
    Department of Otolaryngology Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Ilwon dong 50, Kangnam Ku, Seoul 135 710, South Korea
    Int J Pediatr Otorhinolaryngol 69:1569-74. 2005
    Osteomas of the middle ear are rare benign neoplasms. Most of the cases caused conductive hearing loss and others were asymptomatic and diagnosed incidentally...
  69. ncbi Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery
    S Khalil
    Department of Anesthesiology, University of Texas Medical School at Houston 77030, USA
    J Clin Anesth 11:596-600. 1999
    ....
  70. pmc Blinded multiplex PCR analyses of middle ear and nasopharyngeal fluids from chinchilla models of single- and mixed-pathogen-induced otitis media
    L O Bakaletz
    Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus 43210 1282, USA
    Clin Diagn Lab Immunol 5:219-24. 1998
    ..We conclude that the multiplex PCR analyses are rapid and accurate methodologies when they are used to retrospectively evaluate diverse archival specimens of limited volume from experimental models of otitis media...
  71. ncbi The ototoxic effect of boric acid solutions applied into the middle ear of guinea pigs
    Sedat Oztürkcan
    Department of Otorhinolaryngology and Head and Neck Surgery, Ataturk Research and Training Hospital, Ministry of Health, Izmir, Turkey
    Eur Arch Otorhinolaryngol 266:663-7. 2009
    ..These preparations are used for both their antiseptic and acidic qualities in external and middle ear infections. We investigated the ototoxic effect of boric acid solutions on guinea pigs...
  72. ncbi Localization of osteopontin at calcification sites of cholesteatoma: possible role as a regulator of deposition of calcium phosphate in the middle ear
    Chiaki Makiishi-Shimobayashi
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Auris Nasus Larynx 31:3-9. 2004
    ..To investigate the possibility of OPN as a common regulator of the pathological calcification in the middle ear, we here examined whether or not OPN is localized at the calcification sites of cholesteatoma, which is clearly ..
  73. ncbi Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene
    A Skalova
    Department of Pathology, Medical Faculty of Charles University, Pilsen, Czech Republic
    Pathol Res Pract 204:599-606. 2008
    ..This mutation is a C to T exchange at position 194, resulting in amino acid exchange S65L. No mutation was found in any of the three exons analyzed and in the exon-intron junctions of the VHL gene in the sporadic case...
  74. ncbi Growth factors and their receptors in the middle ear mucosa during otitis media
    Sean D Palacios
    Department of Surgery, University of California, San Diego School of Medicine and Veterans Affairs Medical Center, La Jolla 92093, USA
    Laryngoscope 112:420-3. 2002
    The hyperplastic response of the middle ear mucosa during bacterial otitis media is thought to be mediated by the actions of growth factors and their respective receptors...
  75. ncbi Evolution of the middle ear apparatus in Talpid moles
    Matthew J Mason
    University of Cambridge, Department of Physiology, Cambridge CB2 3EG, UK
    J Morphol 267:678-95. 2006
    The middle ear structures of eight species of mole in the family Talpidae (Mammalia: Eulipotyphla) were studied under light and electron microscopy...
  76. ncbi Effect of bacterial endotoxin and middle ear effusion on ciliary activity: implications for otitis media
    Paul S Mason
    Department of Otorhinolaryngology, Southampton University Hospitals Trust, UK
    Laryngoscope 112:676-80. 2002
    ..The pathogenesis is not fully understood, especially the reasons for failure of mucociliary clearance of the middle ear. It is not clear whether the cilia function normally in the middle ear and eustachian tube in the chronic phase ..
  77. ncbi Comparative anatomy of the paratympanic organ (vitali organ) in the middle ear of birds and non-avian vertebrates: focus on alligators, parakeets and armadillos
    Jason A Neeser
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nev 89557, USA
    Brain Behav Evol 60:65-79. 2002
    The paratympanic organ (PTO) in the middle ear has been described in numerous bird species, but little is known about the distribution of this presumed lateral line remnant in other vertebrate classes...
  78. ncbi Effectiveness of instillation of triamcinolone acetonide into the middle ear for eosinophilic otitis media associated with bronchial asthma
    Yukiko Iino
    Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan
    Ann Allergy Asthma Immunol 97:761-6. 2006
    Eosinophilic otitis media (EOM) is a newly recognized middle ear disease found in asthmatic patients...
  79. ncbi Ciliary and secretory differentiation of normal human middle ear epithelial cells
    Jae Young Choi
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea
    Acta Otolaryngol 122:270-5. 2002
    Recent technical advances now permit the serial culture of normal human middle ear epithelial (NHMEE) cells. However, the ciliary differentiation of these cells has not been achieved...
  80. ncbi Mucous glands in the middle ear - what is known and what is not
    Mirko Tos
    Department of Oto Rhino Laryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Denmark
    ORL J Otorhinolaryngol Relat Spec 64:86-94. 2002
    A review of acquired and lacking knowledge on mucous glands in the human middle ear is presented...
  81. ncbi Pathology of idiopathic encephaloceles into the middle ear
    Salvatore Iurato
    Department of Ophthalmology and Otolaryngology of the University of Bari, Section of Bioacoustics, Policlinico, Bari, Italy
    ORL J Otorhinolaryngol Relat Spec 64:73-9. 2002
    Meningoencephalic herniations into the middle ear and mastoid are rare and histologic information has been supplied only in few reports...
  82. ncbi Effects of ossicular prosthesis mass and section of the stapes tendon on middle ear transmission
    Manohar Bance
    E A R Laboratory, Division of Otolaryngology, Department of Surgery, Dalhousie University, Halifax, Nova Scotia
    J Otolaryngol 36:113-9. 2007
    The effects of changing prosthesis mass on middle ear transmission have not been previously systematically studied. Neither has the effect of stapes tendon sectioning. These are important parameters that can be surgically varied.
  83. ncbi Expression of water channel proteins (aquaporins) in the rat Eustachian tube and middle ear mucosa
    Sung Ho Kang
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Acta Otolaryngol 127:687-92. 2007
    Diverse expression of the different subtypes of aquaporins in different parts of the Eustachian tube and middle ear suggests region-specific functions of the aquaporins in the normal physiology of the tubotympanum and also suggests that ..
  84. ncbi The problem of middle ear cholesteatoma: etiology, genesis and pathobiology. A review
    D Broekaert
    Laboratory of Physiological Chemistry, Faculty of Medicine, State University of Ghent, Belgium
    Acta Otorhinolaryngol Belg 45:355-67. 1991
    This review provides an overview of the problem of middle ear cholesteatoma, and encompasses the following areas: the definition, the light and ultramicroscopic structure, the etiology, the pathogenesis (with special emphasis on the ..
  85. ncbi Dexamethasone increases fluid absorption via Na+/H+ exchanger (NHE) 3 activation in normal human middle ear epithelial cells
    Jae Young Choi
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea
    Eur J Pharmacol 536:12-8. 2006
    The proper homeostasis of the liquid lining the surface of the middle ear cavity is vitally important for maintaining a fluid-free middle ear cavity...
  86. ncbi Efficacy of nasopharyngeal culture in identification of pathogen in middle ear fluid in chronic otitis media with effusion
    O K Eser
    Department of Microbiology and Clinical Microbiology, Hacettepe University, Ankara, Turkey
    Indian J Med Microbiol 27:237-41. 2009
    ..This study aimed at evaluating the accuracy of nasopharyngeal (NP) specimens in the identification of pathogens in the middle ear fluid (MEF) in patients with OME.
  87. ncbi Analysis of 95 cases of squamous cell carcinoma of the external and middle ear
    Min Yin
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Sensory Medicine, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Auris Nasus Larynx 33:251-7. 2006
    To analyze the clinical characteristics, 5-year survival, and prognostic factors of squamous cell carcinoma (SCC) of the external and middle ear.
  88. ncbi Middle ear mucosa regeneration by grafting of artificial mucosa
    Yuichiro Yaguchi
    Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 127:1038-44. 2007
    Artificial middle ear mucosa (AMEM), a sheet of mucosal cells grown on collagen gel populated with fibroblasts, is useful as graft material that is able to promote mucosal regeneration after middle ear surgery.
  89. pmc Extending the chinchilla middle ear epithelial model for mucin gene investigation
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 74:980-5. 2010
    To investigate the expression of recently identified human mucin genes in an in vivo model of the chinchilla middle ear epithelium (CMEE).
  90. ncbi Leaving a lasting impression: ear mold impressions as middle ear foreign bodies
    Abraham Jacob
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43210, USA
    Ann Otol Rhinol Laryngol 115:912-6. 2006
    ..We describe a series of otologic complications from impression material used to make hearing aid molds...
  91. pmc Metallic foreign body in middle ear: an unusual cause of hearing loss
    Anna Eleftheriadou
    Department of Otolaryngology, G Gennimatas Hospital, Athens Greece
    Head Face Med 3:23. 2007
    This is a rare case report of a foreign metallic body found in the middle ear. During the use of an electric welding by a metalworker, a glowing drop of dissolved metal overrun, burning the skin of his external auditory meatus, perforated ..
  92. ncbi Foreign body in the middle ear, a hearing aid complication
    S Shashinder
    University Malaysia Sarawak, Malaysia
    Med J Malaysia 63:267-8. 2008
    ..During the process of making ear mould impression, the impression material accidentally entered the right middle ear. Removal of the ear mould impression was possible permeatally under general anaesthesia.
  93. ncbi Clinical strategies for preventing postoperative nausea and vomitting after middle ear surgery in adult patients
    Yoshitaka Fujii
    First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
    Curr Drug Saf 3:230-9. 2008
    b>Middle ear surgery (tympanoplasty and mastoidectomy) performed under general or local anesthesia is associated with a high incidence of postoperative nausea and vomiting (PONV)...
  94. ncbi Middle ear influence on otoacoustic emissions. I: noninvasive investigation of the human transmission apparatus and comparison with model results
    P Avan
    Laboratoire de biophysique sensorielle EA 2667, Faculte de Medecine, Universite d Auvergne, Clermont Ferrand, France
    Hear Res 140:189-201. 2000
    ..and they can be acoustically detected in the external auditory meatus after backward propagation through the middle ear. In addition to being used to probe the cochlear mechanisms, they are expected to be sensitive to minute changes ..
  95. ncbi Characterization of mucins in human middle ear and Eustachian tube
    J Lin
    Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1157-67. 2001
    Mucins are important glycoproteins in the mucociliary transport system of the middle ear and Eustachian tube. Little is known about mucin expression within this system under physiological and pathological conditions...
  96. ncbi Pressure changes in the human middle ear without opening the eustachian tube
    Hans Wilhelm Pau
    ENT Department, Medical School, University of Rostock, Doberaner Strasse 137 9, Rostock, Germany
    Acta Otolaryngol 129:1182-6. 2009
    By means of a direct, though non-invasive experiment on healthy humans we could demonstrate that middle ear (ME) pressure decreases when the eustachian tube (ET) does not open...
  97. ncbi External and middle ear status related to evoked otoacoustic emission in neonates
    K W Chang
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle
    Arch Otolaryngol Head Neck Surg 119:276-82. 1993
    ..The purpose of this study was to determine the relationship between external auditory canal and middle ear status with click-evoked OAE...
  98. pmc Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant
    Richard Malley
    Division of Infectious Diseases, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Infect Immun 72:4290-2. 2004
    ..challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites...
  99. ncbi Middle ear hemangiona: a case report
    Hiromi Kojima
    Department of Otorhinolaryngology, The Jikei University School of Medicine, 3 25 8 Nishishinbashi Minato Ku, 105 8461 Tokyo, Japan
    Auris Nasus Larynx 35:255-9. 2008
    A middle ear hemangioma was detected in a 51-year-old man who suffered from fullness and hearing loss in the left ear. This case is presented with a review of the relevant literature...
  100. ncbi Mucin gene expression in human middle ear epithelium
    Joseph Edward Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1666-76. 2007
    To investigate the expression of recently identified human mucin genes in human middle ear epithelial (MEE) specimens from in vivo middle ear (ME) tissue and to compare this mucin gene expression with mucin gene expression in an ..
  101. ncbi Carbon dioxide exchange via the mucosa in healthy middle ear
    F Ikarashi
    Department of Otolaryngology, The Nippon Dental University School of Dentistry at Niigata, Japan
    Arch Otolaryngol Head Neck Surg 125:975-8. 1999
    Recent studies have shown that gas exchange via the middle ear mucosa, which is performed between the middle ear cleft and capillaries in the submucosal connective tissue, has an essential role in ventilation and pressure regulation in ..

Research Grants68

  1. HUMAN MIDDLE EAR--FORWARD AND REVERSE SOUND TRANSMISSION
    Sunil Puria; Fiscal Year: 2002
    This project seeks to characterize forward and reverse sound transmission through the human middle ear. One of the most significant discoveries in hearing during the past twenty years has been that a healthy ear not only detects sound but ..
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic middle ear infections...
  3. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..Aim 4: Determine if effective inner ear homeostatic and anti-inflammatory gene expression can be induced by middle ear steroid delivery...
  4. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..that contributes to chronic upper respiratory disorders, including chronic sinusitis, allergic rhinitis, middle ear disease, as well as pulmonary disease that contribute to respiratory morbidity and mortality world wide...
  5. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals...
  6. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
    ..The research also evaluates whether the test battery improves the accuracy of diagnosing middle-ear disease and of identifying hearing loss in adult patients who receive medications that may affect their hearing. ..
  7. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..applicant): It has become evident that innate immunity plays an active role in maintenance of the health of the middle ear, and is also actively engaged during otitis media (OM)...
  8. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..causes infection by inhabiting environmental niches contiguous with the upper respiratory tract, including the middle ear space (otitis media) and the airways in adults with COPD...
  9. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..As a pathogen, it spreads to the lungs (pneumonia), the central nervous system (meningitis), and the middle ear (otitis media). Mortality and morbidity due to S. pneumoniae is seen primarily in the very young and elderly...
  10. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..Mucosal inflammation and disease derived from pneumococcal infections are caused by high bacterial burden in the middle ear and other organs. Successful growth of S...
  11. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..is often refractory to treatment and inflicts significant morbidity in the form of hearing loss and long-term middle ear dysfunction...
  12. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..long-term goal of this research program is to identify and prevent the inflammatory processes by which chronic middle ear disease causes permanent cochlear damage...
  13. CLONING OF THE Hol MUTATION
    Licia Selleri; Fiscal Year: 2009
    ..Additionally, 04/014 mutants exhibit low-set and hypoplastic ear pinnae and their middle ear ossicles are severely affected...
  14. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..Following each episode of acute otitis media, fluid remains in the middle ear for weeks to months and is associated with significant hearing deficit, a sequela that in turn can impair ..
  15. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..SHSe) in children compromises pulmonary function and contributes to respiratory illness, wheeze, cough, asthma, middle ear disease, and sudden infant death syndrome...
  16. 3D Single Fiber Endoscope for Minimally Invasive Surgeries
    Jason Geng; Fiscal Year: 2013
    ..3D surface imaging capability for minimally invasive surgeries, such as otolaryngology surgeries (access sinus, middle ear, inner ear and skull based surgeries), and eye surgeries and drug placement on optic nerves...
  17. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM), or middle ear infection, is a highly prevalent pediatric disease worldwide, ranking first in reasons why children make physician's office and emergency room visits, undergo ..
  18. The Role of Eya4 in Hearing and Disease
    Jonathan G Seidman; Fiscal Year: 2010
    ..In addition, Eya4-/- mice uniformly develop middle ear effusions and purulent otitis media by 6 weeks of age;neither occurs in wildtype or Eya4+/- mice...
  19. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE:Otitis media, or middle ear infection, is a major public health problem in young children both in the US and in the world...
  20. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..will focus on two increasingly prevalent diseases encountered in the primary care office, namely otitis media (middle ear infections) and diabetic retinopathy...
  21. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..b>Middle ear diseases, such as chronic otitis media and otosclerosis, which affect over 30 million people in the U.S...
  22. CELLULAR AND MOLECULAR BIOLOGY OF CHOLESTEATOMA
    RICHARD ARTHUR CHOLE; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Aural cholesteatomas are epithelial cyst-like structures occurring in the middle ear as a complication of otitis media and when infected they are aggressive, recurrent and recalcitrant to treatment...
  23. Genetics &Biology of M. catarrhalis LOS in Otitis Media
    Anthony A Campagnari; Fiscal Year: 2013
    Moraxella catarrhalis is a Gram-negative human mucosal pathogen, a significant cause of middle ear infections and sinusitis in infants and children and an important source of exacerbations in adults with lung disease...
  24. H. influenzae Genes Associated with Acute Otitis Media
    Janet R Gilsdorf; Fiscal Year: 2010
    ..ears of children with otitis media appear to possess specific genes offering increased bacterial fitness in the middle ear that are not required for NTHi colonization of the pharynx, we will use prevalence analysis, as performed on a ..
  25. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..of age and repeat bilateral VT insertions post-palatoplasty to study end as dictated by an algorithm based on middle ear (ME) status...
  26. Effect of the Middle Ear Inflammation On the Inner Ear
    STEVEN SUNG KYUN JUHN; Fiscal Year: 2013
    ..The disease can lead to middle ear and inner ear pathology and hearing loss...
  27. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    ..We will determine the level of NP and middle ear up-regulation of NTHi/Spn epithelial adherence receptors during antecedent respiratory viral infections;define ..
  28. Validation of a Genomic Biomarker of Response to Environmental Tobacco Smoke
    AVRUM E SPIRA; Fiscal Year: 2012
    ..source of childhood morbidity;resulting in lower respiratory illnesses;cough, phlegm, wheeze, and breathlessness;middle ear disease;and a lower level of lung function...
  29. Avian Middle Ear Development
    SUSAN CAROLINE CHAPMAN; Fiscal Year: 2012
    ..and molecular mechanism underlying induction, patterning and cell fate specification in the vertebrate middle ear. This study examines the tissue interactions and functional mechanisms involved in induction and morphogenesis ..
  30. CYTOKINE INFLAMMATORY MEDIATORS AND MUCIN REGULATION IN MIDDLE EAR EPITHELIUM
    Joseph E Kerschner; Fiscal Year: 2013
    ..Specifically, gel-forming mucins (GFM), produced by middle ear mucosa (MEM), are known to be the primary cause of hearing loss which develops in children with chronic OM and ..
  31. Molecular roles in active and passive mechanics in cochlear hair bundles
    ANTHONY WEI PENG; Fiscal Year: 2013
    ..Sound vibrations enter the outer ear through the ear canal and are converted into pressure waves by the middle ear. Pressure waves in the inner ear are converted to an electrical signal via the mechano-electrical transduction (..
  32. Novel Methods to Reduce Children's Secondhand Smoke Exposure
    THEODORE LEE WAGENER; Fiscal Year: 2013
    ..The results from this study will help determine the effects and feasibility of using spit-less, non-combustible nicotine-containing products by caregivers as a method of reducing children's SHSe. ..
  33. Regulation of Inflammation by EGFR in Otitis Media
    Xiangbin Xu; Fiscal Year: 2012
    ..Inflammation in the middle ear caused by microorganisms is a hallmark of OM...
  34. Ossicle vibration measurements in conductive hearing loss
    Steven L Jacques; Fiscal Year: 2013
    ..based on spectral Fourier-domain OCT and can measure vibrations of the ossicles (malleus, incus, stapes) of the middle ear on the scale of nm to [unreadable]m amplitude...
  35. Biomechanical Measurement and Modeling of Normal and Diseased Middle Ears
    Rong Z Gan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The middle ear, composed of ossicles and soft tissues including the tympanic membrane, ligaments, and joints plays a vital role in the transmission of sound and the sense of hearing...
  36. Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss
    Michael J McKenna; Fiscal Year: 2013
    ..prosthesis, an intratympanic bisphosphonate formulation, or both, using safe and well-established techniques of middle ear surgery...
  37. A Middle Ear Twist: Imaging, Physiology & Biomechanics
    RYAN PATRICK JACKSON; Fiscal Year: 2010
    ..This may be particularly important for post-surgical HF hearing preservation. ..
  38. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2013
    ..project will concentrate on two particular descending systems, the medial olivocochlear (MOC) neurons and the middle ear muscle (MEM) motoneurons...
  39. 3-D optical imaging of the in vivo organ of Corti motion at a sub-nanometer scale
    Alfred L Nuttall; Fiscal Year: 2013
    ..develop also has other applications for human health in Otolaryngology: OCT could image the vibration of the middle ear structures as an audiometric method, measure blood flow in the human inner ear to classify which patients with ..
  40. Mechanics of Human Middle & Inner Ear: Basic Science &Clinical Application
    Hideko Heidi Nakajima; Fiscal Year: 2013
    ..The measurements of BC-evoked DP will elucidate BC mechanisms and improve applications of BC for diagnosis and treatment. ..
  41. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment and ..
  42. Mechanisms of Persistence and Recovery in Otitis Media
    Stephen I Wasserman; Fiscal Year: 2013
    ..Aim 3 will elucidate the mechanisms by which recovery from inflammation is regulated in the middle ear (ME), and determine whether pro-recovery factors can ameliorate acute and persistent ME disease...
  43. Proteomic networks of MUC5B infectious/inflammatory induction in Otitis Media
    Diego Preciado; Fiscal Year: 2013
    ..It is a disease of the middle ear space characterized by acute infectious injury and inflammation, acute OM (AOM), progressing to chronic ..
  44. Metabolic regulation in otitis media
    DAYLE ANITA DAINES; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: antibiotic treatment failure in children that results in recurrent middle ear infections (otitis media). These episodes can lead to deafness as well as language development delays...
  45. Phenotypic and Genomic Characterization of Microtia in the Andean Population
    Daniela Varela Luquetti; Fiscal Year: 2013
    ..the severity of outer ear malformation as well as the presence and pattern of hearing impairment and inner and middle ear anomalies...
  46. Phenotypic and Genomic Characterization of Microtia in the Andean Population
    Daniela Varela Luquetti; Fiscal Year: 2012
    ..the severity of outer ear malformation as well as the presence and pattern of hearing impairment and inner and middle ear anomalies...
  47. Middle Ear Response in Otitis Media
    Allen F Ryan; Fiscal Year: 2013
    ..Upon resolution of otitis media the hyperplastic middle ear mucosa can recover to a condition at or close to its original structure, although permanent changes including ..
  48. Structure and Function Relations in Middle Ears
    John J Rosowski; Fiscal Year: 2012
    ..We focus now on four new clinically-relevant structure- function issues: (1) We quantify the contribution of the middle ear to the shape of the auditory threshold curve by (a) comparing middle-ear inputs and outputs to quantify the ..
  49. Investigations of Human Auditory Mechanics
    Hideko Heidi Nakajima; Fiscal Year: 2012
    ..semicircular canal dehiscence;2. discontinuity of the ossicular chain;3. non-aerated middle ear;and 4. stapes fixation (as in Aim 1)...
  50. Dx Ear: An automated tool for diagnosis of otitis media
    JELENA KOVACEVIC; Fiscal Year: 2010
    ..AOM represents a bacterial super infection of the middle ear fluid and OME a sterile effusion that tends to subside spontaneously...
  51. Computer-based holography and middle-ear function
    John J Rosowski; Fiscal Year: 2013
    ..theory that delays associated with wave-travel on the TM contribute to delays in sound-conduction through the middle ear. Additional TM surface and ossicular motion measurements made with modified and artificial ear canals test a ..
  52. Genetic regulation of Inner and Middle Ear Development
    Andrew K Groves; Fiscal Year: 2013
    ..Moreover, the mesenchyme of the first and second branchial arches that generate the middle ear ossicles and the pinna begins to form in Foxi3 mutants, but rapidly succumbs to massive cell death...
  53. INNER EAR FLUID INTERACTIONS
    Alec N Salt; Fiscal Year: 2013
    ..This includes study of the rate of drug elimination from the middle ear and how the applied volume affects perilymph concentration...
  54. Backward and Forward Driven Eardrum Motions
    Jeffrey Tao Cheng; Fiscal Year: 2013
    ..3) Quantify the relationship between (a) TM surface motions and sound energy transmission through the middle ear to the cochlear excitations and (b) Ossicular motion and the sound transformation by the TM in reverse ..
  55. CFM: Longitudinal Outcomes in Children pre-Kindergarten (CLOCK)
    MATTHEW LOUIS SPELTZ; Fiscal Year: 2013
    ..This condition is frequently associated with malformations of the outer, inner and middle ear, mandible, soft tissue, and facial nerve, resulting in varying degrees of facial asymmetry...
  56. Development of Stop Consonants in Children with Repaired Cleft Palate
    David J Zajac; Fiscal Year: 2013
    ..The specific aims of the proposed project are to determine 1) the time course and factors - middle ear status, symbolic language, cleft type, and sex - that account for the emergence of stop consonants in children ..
  57. Middle Ear Pressure Regulation in Health and Disease
    William J Doyle; Fiscal Year: 2013
    ..past 6 years, we have established a unique, NIH funded, Clinical Research Center focused on the physiology of middle ear (ME) pressure (MEP) regulation...
  58. Dynamic Composite Multi-Gradient Systems for Advanced MRI
    Dennis L Parker; Fiscal Year: 2013
    ..This project will use a novel composite gradient system to test that images of the fine structure of inner and middle ear anatomy obtained with magnetic resonance imaging (MRI) and, ultimately, the diagnosis of inner and middle ear ..
  59. Innovative therapy for diseases of the middle ear
    Allen F Ryan; Fiscal Year: 2013
    ..To enhance medical treatment of middle ear disorders, we used sequential selection of phage-display peptide libraries to identify rare, novel peptides that ..
  60. Observing auditory mechanics with pressure and motion measurements
    Elizabeth S Olson; Fiscal Year: 2013
    ..The projects of the first four aims continue and extend our previous work on inner and middle ear mechanics. The final aim develops and evaluates a new method for deep cochlear implant insertion...
  61. Neural Plasticity in the Adult Gustatory System
    David L Hill; Fiscal Year: 2013
    ..Results will also enable a clearer understanding of the neurobiological sequelae of human taste nerve damage sustained pathologically, or during middle ear or oral surgery.
  62. Development of a laser holography otoscope for diagnosis in the clinic
    John J Rosowski; Fiscal Year: 2010
    ..range from the simple (myringotomy and tympanostomy tube insertion) to the complex (total reconstruction of the middle ear after mastoidectomy)...
  63. Bacterial biofilms in otitis media
    WILLIAM E SWORDS; Fiscal Year: 2013
    ..The completion of the proposed work will enhance our understanding of the role of biofilms within the clinical context of otitis media. ..
  64. DEVELOPMENT OF A FIMBRIN VACCINE AGAINST OTITIS MEDIA
    LAUREN BAKALETZ; Fiscal Year: 1999
    Otitis media, or middle ear infection, is the second most prevalent childhood disease with hearing loss its most common complication...
  65. Coupling Strategies for Middle Ear Protheses
    ANN GRONDA; Fiscal Year: 2003
    ..Based on these measures, biocompatible adhesives whose physical properties match those of middle ear structures will be selected and characterized in bench and temporal bone studies...
  66. Central auditory pathway of the middle ear reflex
    Daniel Lee; Fiscal Year: 2007
    The goal of this project is to understand the anatomic and physiologic features of interneurons of the mammalian middle ear muscle (MEM) reflex pathway...
  67. AMPLIFICATION, MIDDLE EAR PATHOLOGY AND ACADEMIC SUCCESS
    NICKOLA NELSON; Fiscal Year: 1993
    ..concept comprehension, and teacher ratings of educational risk among first grade children with and without middle ear pathology (measured by repeated tympanometric and pure-tone screening procedures using ASHA, 1990, guidelines)...
  68. CYLD as a negative regulator for MUC5AC in NTHi-induced otitis media
    Erika Szymanski; Fiscal Year: 2007
    ..infection directly provokes pain and conductive hearing loss by stimulating mucus overproduction in the middle ear. Mucus is largely the product of mucin glycoproteins including MUC5AC, which is strongly upregulated by ..