middle ear

Summary

Top Publications

  1. pmc Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by influenza A virus and Streptococcus pneumoniae opacity variants
    H H Tong
    Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:4289-96. 2003
  2. pmc Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
    Joseph Jurcisek
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 73:3210-8. 2005
  3. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
  4. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
  5. doi Middle ear pressure regulation--complementary active actions of the mastoid and the Eustachian tube
    Michael Gaihede
    Department of Otolaryngology Head and Neck Surgery, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Otol Neurotol 31:603-11. 2010
  6. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
  7. ncbi Tetrapod-like middle ear architecture in a Devonian fish
    Martin D Brazeau
    Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Evolutionary Biology Centre, Uppsala University, Norbyv 18A, SE 752 36 Uppsala, Sweden
    Nature 439:318-21. 2006
  8. ncbi High frequency of Alloiococcus otitidis in the nasopharynx and in the middle ear cavity of otitis-prone children
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Pediatr Otorhinolaryngol 70:1009-14. 2006
  9. ncbi Characterization of a temperature-sensitive mouse middle ear epithelial cell line
    Katsuyuki Tsuchiya
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Acta Otolaryngol 125:823-9. 2005
  10. ncbi Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium
    M Mallo
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Development 127:4127-36. 2000

Detail Information

Publications234 found, 100 shown here

  1. pmc Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by influenza A virus and Streptococcus pneumoniae opacity variants
    H H Tong
    Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:4289-96. 2003
    ..variants, either alone or in combination, to induce cytokine and chemokine genes in primary cultures of human middle ear epithelial (HMEE) cells...
  2. pmc Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
    Joseph Jurcisek
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 73:3210-8. 2005
    ..NTHI forms biofilms in vitro as well as in the chinchilla middle ear, suggesting that biofilm formation in vivo might play an important role in the pathogenesis and chronicity of OM...
  3. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
    ..N-acetyl-neuraminic) acid promotes biofilm formation by NTHi in vitro and bacterial persistence within the middle ear or lung in vivo...
  4. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
    ..Our data demonstrated that CYLD is induced by NTHi in the middle ear and lung of mice...
  5. doi Middle ear pressure regulation--complementary active actions of the mastoid and the Eustachian tube
    Michael Gaihede
    Department of Otolaryngology Head and Neck Surgery, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Otol Neurotol 31:603-11. 2010
    b>Middle ear pressure (MEP) is actively regulated by both the Eustachian tube and the mastoid air cell system.
  6. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
    Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains...
  7. ncbi Tetrapod-like middle ear architecture in a Devonian fish
    Martin D Brazeau
    Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Evolutionary Biology Centre, Uppsala University, Norbyv 18A, SE 752 36 Uppsala, Sweden
    Nature 439:318-21. 2006
    ..in the remodelling of the spiracular tract and suspensorium (jaw suspension) of osteolepiform fishes into the middle ear of tetrapods have remained elusive...
  8. ncbi High frequency of Alloiococcus otitidis in the nasopharynx and in the middle ear cavity of otitis-prone children
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Pediatr Otorhinolaryngol 70:1009-14. 2006
    Colonization of middle ear pathogens is facilitated in the nasopharynx of otitis-prone children, and is associated with the development of otitis media...
  9. ncbi Characterization of a temperature-sensitive mouse middle ear epithelial cell line
    Katsuyuki Tsuchiya
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Acta Otolaryngol 125:823-9. 2005
    Temperature-sensitive mouse middle ear epithelial cells have been successfully established and characterized.
  10. ncbi Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium
    M Mallo
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Development 127:4127-36. 2000
    ..Vibrations in this membrane are then transduced into the inner ear by the ossicle chain of the middle ear, composed of the malleus, incus and stapes...
  11. ncbi Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusion
    Yasuhiro Tsuboi
    Department of Otolaryngology, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, USA
    Acta Otolaryngol 122:153-60. 2002
    Otitis media with mucoid effusion, characterized by mucous cell metaplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a common otological disease that frequently affects young children...
  12. ncbi Comparison of the antiemetic effects of ondansetron and dexamethasone on middle ear surgery
    Berrin Isik
    Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Bsevler, Ankara, Turkey
    Saudi Med J 27:646-51. 2006
    To compare the antiemetic efficacy of ondansetron and dexamethasone in adults undergoing middle ear surgery.
  13. ncbi Evidence of local antibody response against Alloiococcus otitidis in the middle ear cavity of children with otitis media
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    FEMS Immunol Med Microbiol 49:41-5. 2007
    ..otitidis has a pathogenic role and induces local immune response in the middle ear as a true pathogen. Whole bacterial sonicate of A...
  14. doi Evolutionary development of the middle ear in Mesozoic therian mammals
    Qiang Ji
    Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China
    Science 326:278-81. 2009
    The definitive mammalian middle ear (DMME) is defined by the loss of embryonic Meckel's cartilage and disconnection of the middle ear from the mandible in adults...
  15. pmc Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants
    Marisol A Figueira
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Room 508, 774 Albany Street, Boston Medical Center, Boston, MA 02118, USA
    Infect Immun 75:325-33. 2007
    ..influenzae strains, which in turn may impact their virulence. These data demonstrate a central role for complement in innate immune defenses against NT H. influenzae infections and specifically EOM...
  16. ncbi Demonstration of nasopharyngeal and middle ear mucosal biofilms in an animal model of acute otitis media
    Michael Hoa
    Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Otol Rhinol Laryngol 118:292-8. 2009
    We performed this study to determine the role of nasopharyngeal and middle ear (ME) biofilms in acute otitis media (AOM).
  17. ncbi Randomized, double-blind, placebo-controlled, dosed-finding study of the antiemetic effects and tolerability of ramosetron in adults undergoing middle ear surgery
    Yoshitaka Fujii
    Department of Anesthesiology, Toride Kyodo General Hospital, Toride, Japan
    Clin Ther 25:3100-8. 2003
    ..another SSRA, in preventing emetic symptoms in adults in the first 48 hours after the start of anesthesia for middle ear surgery...
  18. pmc Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:87. 2008
    ..We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear.
  19. ncbi Streptococcus pneumoniae forms surface-attached communities in the middle ear of experimentally infected chinchillas
    Sean D Reid
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Infect Dis 199:786-94. 2009
    ..Streptococcus pneumoniae (pneumococcus) causes respiratory and systemic infections that are a major public health problem worldwide. It has been postulated that pneumococci persist in vivo in biofilm communities...
  20. pmc Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media
    Masayuki Furukawa
    Department of Surgery, UCSD School of Medicine, Fir Bldg, Rm 106, 9500 Gilman Dr 0666, La Jolla, CA 92037, USA
    Infect Immun 75:2562-71. 2007
    ..the participation of signaling via the Jun N-terminal protein kinase (JNK) mitogen-activated protein kinase in middle ear mucosal hyperplasia in animal models of bacterial otitis media...
  21. pmc Hag directly mediates the adherence of Moraxella catarrhalis to human middle ear cells
    Brian Bullard
    Department of Medical Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Ave, Health Education Bldg, Rm 267, Toledo, OH 43614, USA
    Infect Immun 73:5127-36. 2005
    ..with a spectinomycin resistance cassette, and the binding of isogenic mutants to primary cultures of human middle ear epithelial cells (HMEE), as well as A549 pneumocytes, was measured...
  22. pmc Clinically applicable multiplex PCR for four middle ear pathogens
    P H Hendolin
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Clin Microbiol 38:125-32. 2000
    ..H. Hendolin, A. Markkanen, J. Ylikoski, and J. J. Wahlfors, J. Clin. Microbiol. 35:2854-2858, 1997) in middle ear effusions (MEEs) was modified to be better suited for clinical use...
  23. ncbi Prophylactic antiemetic effect of midazolam after middle ear surgery
    Jae Sik Jung
    Department of Anesthesiology, Kyungpook National University Hospital, Jung Gu, Daegu, Republic of Korea
    Otolaryngol Head Neck Surg 137:753-6. 2007
    To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
  24. ncbi Middle ear and cochlear disorders result in different DPOAE growth behaviour: implications for the differentiation of sound conductive and cochlear hearing loss
    Daniel D Gehr
    ENT Department, Technische Universitat Munchen, Clinic rechts der Isar, Ismaninger Strasse 22, D 81675 Munich, Germany
    Hear Res 193:9-19. 2004
    ..With an inner ear dysfunction a steeper I/O-function is observed. Due to the linear sound processing of the middle ear, one can assume that the DPOAE growth behaviour remains unaltered with a sound conduction dysfunction...
  25. doi Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Int J Pediatr Otorhinolaryngol 73:677-80. 2009
    ..In the middle ear, proinflammatory cytokines and chemokines are released in association with infection by pathogens, and these ..
  26. ncbi In vitro reconstruction of a three-dimensional middle ear mucosal organ and its in vivo transplantation
    Kota Wada
    Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 126:801-10. 2006
    These experimental findings suggest the feasibility of artificial middle ear mucosa grafting as an effective treatment for achieving mucosal regeneration after middle ear surgery.
  27. ncbi Difference in facial canal anatomy in terms of severity of microtia and deformity of middle ear in patients with microtia
    Hideki Takegoshi
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Laryngoscope 113:635-9. 2003
    To study the difference in the facial canal anatomy in terms of the severity of microtia and deformity of the middle ear in patients with microtia using high-resolution computed tomography (HRCT).
  28. ncbi Squamous cell carcinoma of the external auditory canal and middle ear: an operation combined with preoperative chemoradiotherapy and a free surgical margin
    Takashi Nakagawa
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Otol Neurotol 27:242-8; discussion 249. 2006
    ..Treatment outcomes for squamous cell carcinoma of the temporal bone were evaluated regarding stage, therapeutic strategy, and prognostic factors...
  29. ncbi Virtual endoscopy imaging of the middle ear cavity and ossicles
    T S Karhuketo
    Department of Otorhinolaryngology, Tampere University Hospital, Finland
    Eur Arch Otorhinolaryngol 259:77-83. 2002
    ..Virtual endoscopic images were produced with separate, commercially available software, paying attention to the middle ear cavity and ossicles...
  30. ncbi Central auditory pathways mediating the rat middle ear muscle reflexes
    Daniel J Lee
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:358-69. 2006
    The middle ear muscle (MEM) reflexes function to protect the inner ear from intense acoustic stimuli and to reduce acoustic masking. Sound presented to the same side or to the opposite side activates the MEM reflex on both sides...
  31. ncbi Measurements of human middle ear forward and reverse acoustics: implications for otoacoustic emissions
    Sunil Puria
    Stanford University, Mechanics and Computation Division, Palo Alto, California 94305, USA
    J Acoust Soc Am 113:2773-89. 2003
    ..These measurements can be used to fully characterize the middle ear as a two-port system...
  32. ncbi Radiopaque contrast dye in nasopharynx reaches the middle ear during swallowing and/or yawning
    B Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville 22908, USA
    Acta Otolaryngol 125:625-8. 2005
    Contrast dye in the nasopharynx reaches the middle ear during swallowing and yawning in normal adults. This suggests that displacement of bacteria in nasopharyngeal secretion to the middle ear may occur frequently during sleep.
  33. ncbi Signaling pathways in interleukin-1beta-mediated middle ear mucin secretion
    Joseph E Kerschner
    Division of Pediatric Otolaryngology and the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Laryngoscope 116:207-11. 2006
    ..protein kinase C (PKC), and nitric oxide synthase (NOS) pathways during upregulation of mucin secretion by middle ear epithelium after exposure to interleukin-1beta and to examine the ability of a specific interleukin-1 receptor ..
  34. ncbi An advanced computer-aided geometric modeling and fabrication method for human middle ear
    Qunli Sun
    School of Aerospace and Mechanical Engineering, University of Oklahoma, 865 Asp Avenue, Room 201, Norman, OK 73019, USA
    Med Eng Phys 24:595-606. 2002
    ..a practical and systematic method for reconstructing accurate computer and physical models of the entire human middle ear. The proposed method starts with the histological section preparation of human temporal bone...
  35. ncbi Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma
    Y Iino
    Department of Otolaryngology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Clin Exp Allergy 31:1135-43. 2001
    ..with intractable otitis media associated with bronchial asthma have extensive accumulation of eosinophils in the middle ear mucosa and middle ear effusion, systematic histological and immunohistochemical studies have not been performed.
  36. ncbi Current use of implants in middle ear surgery
    R A Goldenberg
    Department of Otolaryngology, Wright State University School of Medicine, Dayton, Ohio, USA
    Otol Neurotol 22:145-52. 2001
    ..Of the 575 questionnaires mailed, 274 (47%) were returned. Only 248 of the respondents performed middle ear surgery (43%), and their responses constitute the database for this study...
  37. doi Middle ear impedance measurements in large vestibular aqueduct syndrome
    Cem Bilgen
    Ege University, Medical School, Department of Otorhinolaryngology, Izmir, Turkey
    Auris Nasus Larynx 36:263-8. 2009
    To assess the effect of inner ear pressure on middle ear impedance in patients with large vestibular aqueduct syndrome (LVAS).
  38. doi The prevalence and significance of incidental middle ear and mastoid cavity abnormalities on MRI in a pediatric population
    Ali Balci
    Mustafa Kemal University, Faculty of Medicine, Department of Radiology, Antakya 31100, Hatay, Turkey
    Int J Pediatr Otorhinolaryngol 72:1849-54. 2008
    The purposes of this study were to determine the prevalence of abnormalities in the middle ear and mastoid cavity on the magnetic resonance imaging (MRI) in children and correlate the results with clinical data, tympanometric findings and ..
  39. ncbi Anomalous vessel in the middle ear: the role of CT and MR angiography
    J G Caldas
    Department of Radiology, , , Brazil
    Neuroradiology 40:748-51. 1998
    ..These investigations, coupled with knowledge of the embryological development allowed a diagnosis of a complex vascular anomaly in the middle ear and avoided potential surgical complications.
  40. ncbi Inflammatory pseudotumor of the middle ear masquerading as Bell's palsy
    Richard G Lee
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH, USA
    Am J Otolaryngol 28:423-6. 2007
    ..Therefore, the relationship between an IPT and facial nerve paralysis is vital and must be recognized for treatment and to maximize postoperative facial nerve function...
  41. ncbi Middle ear barotrauma with hyperbaric oxygen therapy: incidence and the predictive value of the nine-step inflation/deflation test and otoscopy
    Serdar Karahatay
    Department of Otorhinolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, Ankara, Turkey
    Ear Nose Throat J 87:684-8. 2008
    We conducted a prospective study to determine the incidence of middle ear barotrauma in patients who were undergoing hyperbaric oxygen therapy (HBOT)...
  42. ncbi In vivo adenoviral transduction of the neonatal rat cochlea and middle ear
    S Dazert
    Department of Otolaryngology-Head and Neck Surgery, , , Germany
    Hear Res 151:30-40. 2001
    ..AdV) vector was used for gene transfer of a beta-galactosidase (beta-gal) reporter gene to the neonatal middle ear and cochlea of 5 day old rats...
  43. ncbi Comparison of the efficacy of propofol and metoclopramide in preventing postoperative nausea and vomiting after middle ear surgery
    Yusuf Unal
    Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey
    Saudi Med J 30:778-82. 2009
    To compare the administration of sub hypnotic dose of propofol with metoclopramide and placebo in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery.
  44. ncbi Laser Doppler vibrometry of the middle ear in humans: derivation dependence, variability, and bilateral differences
    Irina Arechvo
    Department of Ear, Nose, and Throat Diseases, Vilnius University Emergency Hospital, Vilnius, Lithuania
    Medicina (Kaunas) 45:878-86. 2009
    ..Derivation dependence, inter- and intrasubject/intertest variability, bilateral differences of the eardrum vibration characteristics have been investigated using laser Doppler vibrometry (LDV)...
  45. pmc The mastoid as a functional rate-limiter of middle ear pressure change
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, 3000 Mt Royal Blvd, Glenshaw, PA 15116, USA
    Int J Pediatr Otorhinolaryngol 71:393-402. 2007
    The physiological function of the mastoid air cell system (MACS) with respect to middle ear (ME) pressure-regulation remains controversial because predictive mathematical models and experimental data to formulate and test hypotheses are ..
  46. pmc Blinded multiplex PCR analyses of middle ear and nasopharyngeal fluids from chinchilla models of single- and mixed-pathogen-induced otitis media
    L O Bakaletz
    Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus 43210 1282, USA
    Clin Diagn Lab Immunol 5:219-24. 1998
    ..We conclude that the multiplex PCR analyses are rapid and accurate methodologies when they are used to retrospectively evaluate diverse archival specimens of limited volume from experimental models of otitis media...
  47. ncbi Localization of osteopontin at calcification sites of cholesteatoma: possible role as a regulator of deposition of calcium phosphate in the middle ear
    Chiaki Makiishi-Shimobayashi
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Auris Nasus Larynx 31:3-9. 2004
    ..To investigate the possibility of OPN as a common regulator of the pathological calcification in the middle ear, we here examined whether or not OPN is localized at the calcification sites of cholesteatoma, which is clearly ..
  48. doi The ototoxic effect of boric acid solutions applied into the middle ear of guinea pigs
    Sedat Oztürkcan
    Department of Otorhinolaryngology and Head and Neck Surgery, Ataturk Research and Training Hospital, Ministry of Health, Izmir, Turkey
    Eur Arch Otorhinolaryngol 266:663-7. 2009
    ..These preparations are used for both their antiseptic and acidic qualities in external and middle ear infections. We investigated the ototoxic effect of boric acid solutions on guinea pigs...
  49. doi Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene
    A Skalova
    Department of Pathology, Medical Faculty of Charles University, Pilsen, Czech Republic
    Pathol Res Pract 204:599-606. 2008
    ..This mutation is a C to T exchange at position 194, resulting in amino acid exchange S65L. No mutation was found in any of the three exons analyzed and in the exon-intron junctions of the VHL gene in the sporadic case...
  50. ncbi Comparative anatomy of the paratympanic organ (vitali organ) in the middle ear of birds and non-avian vertebrates: focus on alligators, parakeets and armadillos
    Jason A Neeser
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nev 89557, USA
    Brain Behav Evol 60:65-79. 2002
    The paratympanic organ (PTO) in the middle ear has been described in numerous bird species, but little is known about the distribution of this presumed lateral line remnant in other vertebrate classes...
  51. ncbi A huge osteoma of the middle ear
    Yang Sun Cho
    Department of Otolaryngology Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Ilwon dong 50, Kangnam Ku, Seoul 135 710, South Korea
    Int J Pediatr Otorhinolaryngol 69:1569-74. 2005
    Osteomas of the middle ear are rare benign neoplasms. Most of the cases caused conductive hearing loss and others were asymptomatic and diagnosed incidentally...
  52. ncbi Effect of bacterial endotoxin and middle ear effusion on ciliary activity: implications for otitis media
    Paul S Mason
    Department of Otorhinolaryngology, Southampton University Hospitals Trust, UK
    Laryngoscope 112:676-80. 2002
    ..The pathogenesis is not fully understood, especially the reasons for failure of mucociliary clearance of the middle ear. It is not clear whether the cilia function normally in the middle ear and eustachian tube in the chronic phase ..
  53. ncbi Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery
    S Khalil
    Department of Anesthesiology, University of Texas Medical School at Houston 77030, USA
    J Clin Anesth 11:596-600. 1999
    ....
  54. ncbi Effectiveness of instillation of triamcinolone acetonide into the middle ear for eosinophilic otitis media associated with bronchial asthma
    Yukiko Iino
    Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan
    Ann Allergy Asthma Immunol 97:761-6. 2006
    Eosinophilic otitis media (EOM) is a newly recognized middle ear disease found in asthmatic patients...
  55. ncbi The problem of middle ear cholesteatoma: etiology, genesis and pathobiology. A review
    D Broekaert
    Laboratory of Physiological Chemistry, Faculty of Medicine, State University of Ghent, Belgium
    Acta Otorhinolaryngol Belg 45:355-67. 1991
    This review provides an overview of the problem of middle ear cholesteatoma, and encompasses the following areas: the definition, the light and ultramicroscopic structure, the etiology, the pathogenesis (with special emphasis on the ..
  56. ncbi Evolution of the middle ear apparatus in Talpid moles
    Matthew J Mason
    University of Cambridge, Department of Physiology, Cambridge CB2 3EG, UK
    J Morphol 267:678-95. 2006
    The middle ear structures of eight species of mole in the family Talpidae (Mammalia: Eulipotyphla) were studied under light and electron microscopy...
  57. ncbi Effects of ossicular prosthesis mass and section of the stapes tendon on middle ear transmission
    Manohar Bance
    E A R Laboratory, Division of Otolaryngology, Department of Surgery, Dalhousie University, Halifax, Nova Scotia
    J Otolaryngol 36:113-9. 2007
    The effects of changing prosthesis mass on middle ear transmission have not been previously systematically studied. Neither has the effect of stapes tendon sectioning. These are important parameters that can be surgically varied.
  58. ncbi Expression of water channel proteins (aquaporins) in the rat Eustachian tube and middle ear mucosa
    Sung Ho Kang
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Acta Otolaryngol 127:687-92. 2007
    Diverse expression of the different subtypes of aquaporins in different parts of the Eustachian tube and middle ear suggests region-specific functions of the aquaporins in the normal physiology of the tubotympanum and also suggests that ..
  59. ncbi Pathology of idiopathic encephaloceles into the middle ear
    Salvatore Iurato
    Department of Ophthalmology and Otolaryngology of the University of Bari, Section of Bioacoustics, Policlinico, Bari, Italy
    ORL J Otorhinolaryngol Relat Spec 64:73-9. 2002
    Meningoencephalic herniations into the middle ear and mastoid are rare and histologic information has been supplied only in few reports...
  60. ncbi Mucous glands in the middle ear - what is known and what is not
    Mirko Tos
    Department of Oto Rhino Laryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Denmark
    ORL J Otorhinolaryngol Relat Spec 64:86-94. 2002
    A review of acquired and lacking knowledge on mucous glands in the human middle ear is presented...
  61. ncbi Ciliary and secretory differentiation of normal human middle ear epithelial cells
    Jae Young Choi
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea
    Acta Otolaryngol 122:270-5. 2002
    Recent technical advances now permit the serial culture of normal human middle ear epithelial (NHMEE) cells. However, the ciliary differentiation of these cells has not been achieved...
  62. ncbi Growth factors and their receptors in the middle ear mucosa during otitis media
    Sean D Palacios
    Department of Surgery, University of California, San Diego School of Medicine and Veterans Affairs Medical Center, La Jolla 92093, USA
    Laryngoscope 112:420-3. 2002
    The hyperplastic response of the middle ear mucosa during bacterial otitis media is thought to be mediated by the actions of growth factors and their respective receptors...
  63. ncbi Middle ear mucosa regeneration by grafting of artificial mucosa
    Yuichiro Yaguchi
    Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 127:1038-44. 2007
    Artificial middle ear mucosa (AMEM), a sheet of mucosal cells grown on collagen gel populated with fibroblasts, is useful as graft material that is able to promote mucosal regeneration after middle ear surgery.
  64. ncbi Analysis of 95 cases of squamous cell carcinoma of the external and middle ear
    Min Yin
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Sensory Medicine, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Auris Nasus Larynx 33:251-7. 2006
    To analyze the clinical characteristics, 5-year survival, and prognostic factors of squamous cell carcinoma (SCC) of the external and middle ear.
  65. pmc Extending the chinchilla middle ear epithelial model for mucin gene investigation
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 74:980-5. 2010
    To investigate the expression of recently identified human mucin genes in an in vivo model of the chinchilla middle ear epithelium (CMEE).
  66. ncbi Dexamethasone increases fluid absorption via Na+/H+ exchanger (NHE) 3 activation in normal human middle ear epithelial cells
    Jae Young Choi
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea
    Eur J Pharmacol 536:12-8. 2006
    The proper homeostasis of the liquid lining the surface of the middle ear cavity is vitally important for maintaining a fluid-free middle ear cavity...
  67. doi Efficacy of nasopharyngeal culture in identification of pathogen in middle ear fluid in chronic otitis media with effusion
    O K Eser
    Department of Microbiology and Clinical Microbiology, Hacettepe University, Ankara, Turkey
    Indian J Med Microbiol 27:237-41. 2009
    ..This study aimed at evaluating the accuracy of nasopharyngeal (NP) specimens in the identification of pathogens in the middle ear fluid (MEF) in patients with OME.
  68. ncbi Foreign body in the middle ear, a hearing aid complication
    S Shashinder
    University Malaysia Sarawak, Malaysia
    Med J Malaysia 63:267-8. 2008
    ..During the process of making ear mould impression, the impression material accidentally entered the right middle ear. Removal of the ear mould impression was possible permeatally under general anaesthesia.
  69. pmc Metallic foreign body in middle ear: an unusual cause of hearing loss
    Anna Eleftheriadou
    Department of Otolaryngology, G Gennimatas Hospital, Athens Greece
    Head Face Med 3:23. 2007
    This is a rare case report of a foreign metallic body found in the middle ear. During the use of an electric welding by a metalworker, a glowing drop of dissolved metal overrun, burning the skin of his external auditory meatus, perforated ..
  70. ncbi Leaving a lasting impression: ear mold impressions as middle ear foreign bodies
    Abraham Jacob
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43210, USA
    Ann Otol Rhinol Laryngol 115:912-6. 2006
    ..We describe a series of otologic complications from impression material used to make hearing aid molds...
  71. ncbi Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion
    Mohamed Nasser Elsheikh
    Department of Otolaryngology, Tanta University, Egypt
    Laryngoscope 116:365-9. 2006
    ..We investigated the expression of MUC5AC and MUC5B mucin gene messenger (m)RNAs in middle ear effusions as well as in tissue biopsies of the respiratory mucosa of the nasopharynx by means of reverse-..
  72. ncbi Characterization of mucins in human middle ear and Eustachian tube
    J Lin
    Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1157-67. 2001
    Mucins are important glycoproteins in the mucociliary transport system of the middle ear and Eustachian tube. Little is known about mucin expression within this system under physiological and pathological conditions...
  73. ncbi Middle ear hemangiona: a case report
    Hiromi Kojima
    Department of Otorhinolaryngology, The Jikei University School of Medicine, 3 25 8 Nishishinbashi Minato Ku, 105 8461 Tokyo, Japan
    Auris Nasus Larynx 35:255-9. 2008
    A middle ear hemangioma was detected in a 51-year-old man who suffered from fullness and hearing loss in the left ear. This case is presented with a review of the relevant literature...
  74. ncbi Capillary hemangioma of the middle ear
    Taryn Davids
    Department of Otolaryngology Head and Neck Surgery, McMaster University, Hamilton, Ontario
    J Otolaryngol 35:196-9. 2006
  75. pmc Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant
    Richard Malley
    Division of Infectious Diseases, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Infect Immun 72:4290-2. 2004
    ..challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites...
  76. ncbi Middle ear influence on otoacoustic emissions. I: noninvasive investigation of the human transmission apparatus and comparison with model results
    P Avan
    Laboratoire de biophysique sensorielle EA 2667, Faculte de Medecine, Universite d Auvergne, Clermont Ferrand, France
    Hear Res 140:189-201. 2000
    ..and they can be acoustically detected in the external auditory meatus after backward propagation through the middle ear. In addition to being used to probe the cochlear mechanisms, they are expected to be sensitive to minute changes ..
  77. ncbi Alteration of gene expression in human middle ear epithelial cells induced by influenza A virus and its implication for the pathogenesis of otitis media
    Hua Hua Tong
    Division of Otologic Research, Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Room 4331 Cramblett, 456 W 10th Avenue, Columbus, OH 43210, USA
    Microb Pathog 37:193-204. 2004
    ..We used microarray technology to characterize the mRNA expression profile in human middle ear epithelial cells induced by influenza A virus...
  78. ncbi Chinchilla middle ear epithelial mucin gene expression in response to inflammatory cytokines
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 130:1163-7. 2004
    ..importance of mucin on a molecular level in the understanding of the pathophysiology of otitis media and to present new data demonstrating differential up-regulation of specific mucin genes during inflammation of middle ear epithelium.
  79. ncbi Capillary hemangioma of the middle ear
    Po Jen Hsueh
    Department of Otolaryngology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    Otolaryngol Head Neck Surg 136:666-7. 2007
  80. ncbi Carbon dioxide exchange via the mucosa in healthy middle ear
    F Ikarashi
    Department of Otolaryngology, The Nippon Dental University School of Dentistry at Niigata, Japan
    Arch Otolaryngol Head Neck Surg 125:975-8. 1999
    Recent studies have shown that gas exchange via the middle ear mucosa, which is performed between the middle ear cleft and capillaries in the submucosal connective tissue, has an essential role in ventilation and pressure regulation in ..
  81. ncbi Mucin gene expression in human middle ear epithelium
    Joseph Edward Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1666-76. 2007
    To investigate the expression of recently identified human mucin genes in human middle ear epithelial (MEE) specimens from in vivo middle ear (ME) tissue and to compare this mucin gene expression with mucin gene expression in an ..
  82. ncbi Clinical strategies for preventing postoperative nausea and vomitting after middle ear surgery in adult patients
    Yoshitaka Fujii
    First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
    Curr Drug Saf 3:230-9. 2008
    b>Middle ear surgery (tympanoplasty and mastoidectomy) performed under general or local anesthesia is associated with a high incidence of postoperative nausea and vomiting (PONV)...
  83. doi Pressure changes in the human middle ear without opening the eustachian tube
    Hans Wilhelm Pau
    ENT Department, Medical School, University of Rostock, Doberaner Strasse 137 9, Rostock, Germany
    Acta Otolaryngol 129:1182-6. 2009
    By means of a direct, though non-invasive experiment on healthy humans we could demonstrate that middle ear (ME) pressure decreases when the eustachian tube (ET) does not open...
  84. doi Fluorescence "in situ" hybridization for the detection of biofilm in the middle ear and upper respiratory tract mucosa
    Laura Nistico
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    Methods Mol Biol 493:191-213. 2009
    ..microscopy (CLSM)-based 16S rRNA fluorescence in situ hybridization (FISH) protocol, to find biofilm bacteria in middle ear and upper respiratory tract mucosa, which preserves the three-dimensional structure of the biofilm and avoids ..
  85. ncbi Middle ear hemangioma: a case report
    Cigdem Tokyol
    Department of Pathology, Kocatepe University, Afyon, Turkey
    Am J Otolaryngol 24:405-7. 2003
    Hemangiomas are common benign vascular tumors, but they have rarely been reported in the middle ear. They can mimic glomus tumor in appearance when encountered as middle ear masses...
  86. ncbi External and middle ear status related to evoked otoacoustic emission in neonates
    K W Chang
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle
    Arch Otolaryngol Head Neck Surg 119:276-82. 1993
    ..The purpose of this study was to determine the relationship between external auditory canal and middle ear status with click-evoked OAE...
  87. ncbi Autoregulation of human inner ear blood flow during middle ear surgery with propofol or isoflurane anesthesia during controlled hypotension
    M P Preckel
    Service d Anesthesie Reanimation, Centre Hospitalier Universitaire, Angers, France
    Anesth Analg 87:1002-8. 1998
    We used controlled hypotension to obtain a bloodless cavity during middle ear surgery under an optical microscope...
  88. pmc Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx
    Jennelle M Kyd
    Division of Science and Design, Gadi Research Centre, University of Canberra, Canberra, Australia
    Infect Immun 71:4691-9. 2003
    The rat middle ear and lung clearance model has been used to show that the nontypeable Haemophilus influenzae 26-kDa outer membrane protein OMP26 is highly efficacious as a mucosal immunogen, inducing significantly enhanced clearance in ..
  89. ncbi Management of middle ear hemangiomas
    D A Hecht
    Department of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC, USA
    Am J Otolaryngol 22:362-6. 2001
    Hemangioma rarely presents as an isolated middle ear lesion. Because congenital hemangiomas usually regress spontaneously, surgical excision is not always necessary...
  90. doi Differential expression of toll-like receptors 2 and 4 in rat middle ear
    Jae Jun Song
    Department of Otorhinolaryngology Head and Neck Surgery, Dongguk University International Hospital, Gyeonggi, South Korea
    Int J Pediatr Otorhinolaryngol 73:821-4. 2009
    The epithelial cells of the middle ear and Eustachian tube must maintain an adequate mucosal defense system against various antigenic stimuli...
  91. ncbi Eosinophil chemoattractants in the middle ear of patients with eosinophilic otitis media
    Y Iino
    Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan
    Clin Exp Allergy 35:1370-6. 2005
    ..associated with bronchial asthma have an extensive accumulation of eosinophils in the effusion and mucosa of the middle ear; this condition is called eosinophilic otitis media (EOM)...
  92. ncbi Control of symptoms in patients with Meniere's disease using middle ear pressure applications: two years follow-up
    B Densert
    City Clinics, Otology Unit, General Hospital, Halmstad, Sweden
    Acta Otolaryngol 121:616-21. 2001
    The effects of middle ear pressure pulses were studied in 37 patients with a diagnosis of definite Meniere's disease and active vestibular symptoms, 31 of whom had failed to respond to medical treatment including diuretics prior to ..
  93. pmc Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
    Sung Kyun Moon
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 6:12. 2006
    ..transcription of beta-defensin 2 (DEFB4 according to new nomenclature of the Human Genome Organization) in human middle ear epithelial cells via a Src-dependent Raf-MEK1/2-ERK signaling pathway...
  94. ncbi Comparison of multidetector row CT cross-sectional source images with multiplanar 2D-, 3D- reconstructions and virtual endoscopy in assessment of the middle ear
    A Trojanowska
    J Neuroradiol 33:277-8. 2006
  95. ncbi Neuroendocrine adenoma of the middle ear
    Lester D R Thompson
    Department of Pathology, Woodland Hills Medical Center, Southern California Permanente Medical Group, Woodland Hills, CA, USA
    Ear Nose Throat J 84:560-1. 2005
  96. ncbi Ultrastructural morphology of a middle ear ceruminoma
    Peter Schenk
    Department of Otorhinolaryngology, Vienna Medical School, Wahringer Gurtel 18 20, A 1090 Vienna, Vienna, Austria
    ORL J Otorhinolaryngol Relat Spec 64:358-63. 2002
    The ultrastructural morphology of a ceruminous gland adenoma in the middle ear was examined electron microscopically...
  97. ncbi Isolation of measles virus from middle ear fluid of infants with acute otitis media
    Hisakazu Yano
    Department of Otolaryngology, Tohoku Rosai Hospital, Aoba ku, Sendai 981 8563, Japan
    J Infect 51:e237-40. 2005
    Measles virus was isolated from the middle ear fluid (MEF) of two infant cases of acute otitis media (AOM) associated with measles...
  98. ncbi Middle ear pressure changes during anesthesia with or without nitrous oxide are similar among airway devices
    Mathias Hohlrieder
    Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesth Analg 102:319-21. 2006
    We tested the hypothesis that middle ear pressure (MEP) is influenced by the choice of airway device during anesthesia with or without nitrous oxide (N2O) in the gas mixture...
  99. ncbi Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: the pathological basis for mucin hyperproduction in mucoid otitis media
    Hirokazu Kawano
    University of Minnesota Otitis Media Research Center, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, USA
    Ann Otol Rhinol Laryngol 111:415-22. 2002
    ..of the leading causes of acquired hearing loss in children, is characterized by mucous cell hyperplasia in the middle ear cleft associated with mucin accumulation in the middle ear cavity...
  100. ncbi Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature
    Kevin R Torske
    Department of Endocrine and Otorhinolaryngic Head and Neck Pathology, Armed Forces Institute of Pathology, Washington, D C
    Mod Pathol 15:543-55. 2002
    Carcinoid tumors and adenomas of the middle ear are rare neoplasms of indeterminate relationship to one another...
  101. ncbi Anomalies of the middle and inner ear
    Kimsey Rodriguez
    Department of Otolaryngology Head and Neck Surgery, Tulane University School of Medicine, New Orleans, LA, USA
    Otolaryngol Clin North Am 40:81-96, vi. 2007
    ..This process, along with development of the middle ear, continues throughout gestation...

Research Grants87

  1. HUMAN MIDDLE EAR--FORWARD AND REVERSE SOUND TRANSMISSION
    Sunil Puria; Fiscal Year: 2002
    This project seeks to characterize forward and reverse sound transmission through the human middle ear. One of the most significant discoveries in hearing during the past twenty years has been that a healthy ear not only detects sound but ..
  2. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2005
    ..abstract_text> ..
  3. Otitis media-associated pneumococcal genes
    Jing Ren Zhang; Fiscal Year: 2007
    ..The pathogenesis of pneumococcal infection in the middle ear depends on bacterial adherence to mucosal epithelial cells...
  4. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2010
    ..Mucosal inflammation and disease derived from pneumococcal infections are caused by high bacterial burden in the middle ear and other organs. Successful growth of S...
  5. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    JAMES BRYERS; Fiscal Year: 2009
    ..the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic middle ear infections...
  6. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2010
    The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals...
  7. Human middle-ear imaging, physiology, and biomechanics
    Charles Steele; Fiscal Year: 2009
    The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals...
  8. Human middle-ear imaging, physiology, and biomechanics
    Charles Steele; Fiscal Year: 2009
    The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals...
  9. Observing Auditory Mechanics with Pressure and Motion
    Elizabeth Olson; Fiscal Year: 2003
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  10. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2005
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  11. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    DOUGLAS KEEFE; Fiscal Year: 2009
    ..The research also evaluates whether the test battery improves the accuracy of diagnosing middle-ear disease and of identifying hearing loss in adult patients who receive medications that may affect their hearing. ..
  12. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    DOUGLAS H contact KEEFE; Fiscal Year: 2010
    ..The research also evaluates whether the test battery improves the accuracy of diagnosing middle-ear disease and of identifying hearing loss in adult patients who receive medications that may affect their hearing. ..
  13. Human middle ear imaging, physiology, and biomechanics
    Charles Steele; Fiscal Year: 2006
    The overall goal of this project is to understand the relationship between human middle ear morphemetry and the biomechanical processes that lead to physiological responses...
  14. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2010
    Otitis media (OM), or middle ear infection, is a highly prevalent pediatric disease worldwide, ranking first in reasons why children make physician's office and emergency room visits, undergo surgery requiring general anesthesia, ..
  15. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Otitis media (OM), or middle ear infection, is a highly prevalent pediatric disease worldwide, ranking first in reasons why children make physician's office and emergency room visits, undergo ..
  16. Development of a laser holography otoscope for diagnosis in the clinic
    John J Rosowski; Fiscal Year: 2010
    ..range from the simple (myringotomy and tympanostomy tube insertion) to the complex (total reconstruction of the middle ear after mastoidectomy)...
  17. In Vivo Virulence Gene Expression in Acute Otitis Media
    Ha Sheng Li Korotky; Fiscal Year: 2007
    ..The ability of S. pneumoniae to bind to the host middle ear mucosa (MEM) is a critical step to initiate OM. The mechanisms that control S...
  18. Inner Ear Impact of Chronic Middle Ear Inflammation
    Dennis Trune; Fiscal Year: 2009
    ..long-term goal of this research program is to identify and prevent the inflammatory processes by which chronic middle ear disease causes permanent cochlear damage...
  19. Inner Ear Impact of Chronic Middle Ear Inflammation
    Dennis Trune; Fiscal Year: 2009
    ..long-term goal of this research program is to identify and prevent the inflammatory processes by which chronic middle ear disease causes permanent cochlear damage...
  20. Antimicrobial Peptides and Innate Immunity in Otitis Media
    LAUREN BAKALETZ; Fiscal Year: 2009
    It has become evident that innate immunity plays an active role in maintenance of the health of the middle ear, and is also actively engaged during otitis media (OM)...
  21. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2010
    It has become evident that innate immunity plays an active role in maintenance of the health of the middle ear, and is also actively engaged during otitis media (OM)...
  22. Antimicrobial Peptides and Innate Immunity in Otitis Media
    LAUREN BAKALETZ; Fiscal Year: 2009
    It has become evident that innate immunity plays an active role in maintenance of the health of the middle ear, and is also actively engaged during otitis media (OM)...
  23. Middle-ear Mechanics in Normal and Pathological Ears
    Saumil N Merchant; Fiscal Year: 2010
    ..b>Middle ear diseases, such as chronic otitis media (COM), which affect over 10 million people in the U.S...
  24. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2009
    ..b>Middle ear diseases, such as chronic otitis media (COM), which affect over 10 million people in the U.S...
  25. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2007
    ..b>Middle ear diseases, such as chronic otitis media (COM), which affect over 10 million people in the U.S...
  26. Coupling Strategies for Middle Ear Protheses
    ANN GRONDA; Fiscal Year: 2003
    ..Based on these measures, biocompatible adhesives whose physical properties match those of middle ear structures will be selected and characterized in bench and temporal bone studies...
  27. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2009
    Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment and dizziness in children...
  28. Effect of the Middle Ear Inflammation On the Inner Ear
    Steven Juhn; Fiscal Year: 2007
    ..Chronic OM, with effusion arises from a complex series of inflammatory events in the middle ear and affects approximately 5% to 30% of children...
  29. Central auditory pathway of the middle ear reflex
    Daniel Lee; Fiscal Year: 2007
    The goal of this project is to understand the anatomic and physiologic features of interneurons of the mammalian middle ear muscle (MEM) reflex pathway...
  30. A Middle Ear Twist: Imaging, Physiology & Biomechanics
    Ryan Jackson; Fiscal Year: 2009
    ..This may be particularly important for post-surgical HF hearing preservation. ..
  31. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    LAUREN BAKALETZ; Fiscal Year: 2007
    b>Middle ear infection or otitis media (OM) is a highly prevalent pediatric disease worldwide...
  32. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    LAUREN BAKALETZ; Fiscal Year: 2009
    b>Middle ear infection or otitis media (OM) is a highly prevalent pediatric disease worldwide...
  33. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    Joseph W St Geme; Fiscal Year: 2010
    ..Following each episode of acute otitis media, fluid remains in the middle ear for weeks to months and is associated with significant hearing deficit, a sequela that in turn can impair ..
  34. Antimicrobial Peptides & Innate Immunity in Otitis Media
    LAUREN BAKALETZ; Fiscal Year: 2006
    ..are compromised, these bacteria can behave as opportunistic pathogens and gain access to the now poorly defended middle ear. It is well known that colonization of the NP is thus the very first step in the disease course of OM...
  35. CYLD as a negative regulator for MUC5AC in NTHi-induced otitis media
    Erika Szymanski; Fiscal Year: 2007
    ..infection directly provokes pain and conductive hearing loss by stimulating mucus overproduction in the middle ear. Mucus is largely the product of mucin glycoproteins including MUC5AC, which is strongly upregulated by ..