Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by influenza A virus and Streptococcus pneumoniae opacity variantsH H Tong
Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
Infect Immun 71:4289-96. 2003
..variants, either alone or in combination, to induce cytokine and chemokine genes in primary cultures of human middle ear epithelial (HMEE) cells...
- Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
Haa Yung Lee
The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
BMC Infect Dis 8:87. 2008
..We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear.
Demonstration of nasopharyngeal and middle ear mucosal biofilms in an animal model of acute otitis mediaMichael Hoa
Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
Ann Otol Rhinol Laryngol 118:292-8. 2009
We performed this study to determine the role of nasopharyngeal and middle ear (ME) biofilms in acute otitis media (AOM).
- Streptococcus pneumoniae forms surface-attached communities in the middle ear of experimentally infected chinchillas
Sean D Reid
Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Infect Dis 199:786-94. 2009
..Streptococcus pneumoniae (pneumococcus) causes respiratory and systemic infections that are a major public health problem worldwide. It has been postulated that pneumococci persist in vivo in biofilm communities...
- Randomized, double-blind, placebo-controlled, dosed-finding study of the antiemetic effects and tolerability of ramosetron in adults undergoing middle ear surgery
Yoshitaka Fujii
Department of Anesthesiology, Toride Kyodo General Hospital, Toride, Japan
Clin Ther 25:3100-8. 2003
..another SSRA, in preventing emetic symptoms in adults in the first 48 hours after the start of anesthesia for middle ear surgery...
- Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants
Marisol A Figueira
Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Room 508, 774 Albany Street, Boston Medical Center, Boston, MA 02118, USA
Infect Immun 75:325-33. 2007
..influenzae strains, which in turn may impact their virulence. These data demonstrate a central role for complement in innate immune defenses against NT H. influenzae infections and specifically EOM...
Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidisAtsushi Harimaya
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
Int J Pediatr Otorhinolaryngol 73:677-80. 2009
..In the middle ear, proinflammatory cytokines and chemokines are released in association with infection by pathogens, and these ..
- Foreign body in the middle ear, a hearing aid complication
S Shashinder
University Malaysia Sarawak, Malaysia
Med J Malaysia 63:267-8. 2008
..During the process of making ear mould impression, the impression material accidentally entered the right middle ear. Removal of the ear mould impression was possible permeatally under general anaesthesia.
- Leaving a lasting impression: ear mold impressions as middle ear foreign bodies
Abraham Jacob
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43210, USA
Ann Otol Rhinol Laryngol 115:912-6. 2006
..These patients may benefit from evaluation in conjunction with an otolaryngologist...
- Metallic foreign body in middle ear: an unusual cause of hearing loss
Anna Eleftheriadou
Department of Otolaryngology, G Gennimatas Hospital, Athens Greece
Head Face Med 3:23. 2007
This is a rare case report of a foreign metallic body found in the middle ear. During the use of an electric welding by a metalworker, a glowing drop of dissolved metal overrun, burning the skin of his external auditory meatus, perforated ..
- Prophylactic antiemetic effect of midazolam after middle ear surgery
Jae Sik Jung
Department of Anesthesiology, Kyungpook National University Hospital, Jung Gu, Daegu, Republic of Korea
Otolaryngol Head Neck Surg 137:753-6. 2007
To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
- Alteration of gene expression in human middle ear epithelial cells induced by influenza A virus and its implication for the pathogenesis of otitis media
Hua Hua Tong
Division of Otologic Research, Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Room 4331 Cramblett, 456 W. 10th Avenue, Columbus, OH 43210, USA
Microb Pathog 37:193-204. 2004
..We used microarray technology to characterize the mRNA expression profile in human middle ear epithelial cells induced by influenza A virus...
- Characterization of mucins in human middle ear and Eustachian tube
J Lin
Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
Am J Physiol Lung Cell Mol Physiol 280:L1157-67. 2001
Mucins are important glycoproteins in the mucociliary transport system of the middle ear and Eustachian tube. Little is known about mucin expression within this system under physiological and pathological conditions...
- Capillary hemangioma of the middle ear
Taryn Davids
Department of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario
J Otolaryngol 35:196-9. 2006
- Mucin gene expression in human middle ear epithelium
Joseph Edward Kerschner
Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
Laryngoscope 117:1666-76. 2007
To investigate the expression of recently identified human mucin genes in human middle ear epithelial (MEE) specimens from in vivo middle ear (ME) tissue and to compare this mucin gene expression with mucin gene expression in an ..
- Management of middle ear hemangiomas
D A Hecht
Department of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC, USA
Am J Otolaryngol 22:362-6. 2001
Hemangioma rarely presents as an isolated middle ear lesion. Because congenital hemangiomas usually regress spontaneously, surgical excision is not always necessary...
- Clinical strategies for preventing postoperative nausea and vomitting after middle ear surgery in adult patients
Yoshitaka Fujii
First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
Curr Drug Saf 3:230-9. 2008
b>Middle ear surgery (tympanoplasty and mastoidectomy) performed under general or local anesthesia is associated with a high incidence of postoperative nausea and vomiting (PONV)...
- Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant
Richard Malley
Division of Infectious Diseases, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
Infect Immun 72:4290-2. 2004
..challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites...
- Middle ear hemangiona: a case report
Hiromi Kojima
Department of Otorhinolaryngology, The Jikei University School of Medicine, 3 25 8 Nishishinbashi Minato Ku, 105 8461 Tokyo, Japan
Auris Nasus Larynx 35:255-9. 2008
A middle ear hemangioma was detected in a 51-year-old man who suffered from fullness and hearing loss in the left ear. This case is presented with a review of the relevant literature...
- Middle ear hemangioma: a case report
Cigdem Tokyol
Department of Pathology, Kocatepe University, Afyon, Turkey
Am J Otolaryngol 24:405-7. 2003
Hemangiomas are common benign vascular tumors, but they have rarely been reported in the middle ear. They can mimic glomus tumor in appearance when encountered as middle ear masses...
- Capillary hemangioma of the middle ear
Po-Jen Hsueh
Department of Otolaryngology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
Otolaryngol Head Neck Surg 136:666-7. 2007
- Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx
Jennelle M Kyd
Division of Science and Design, Gadi Research Centre, University of Canberra, Canberra, Australia
Infect Immun 71:4691-9. 2003
The rat middle ear and lung clearance model has been used to show that the nontypeable Haemophilus influenzae 26-kDa outer membrane protein OMP26 is highly efficacious as a mucosal immunogen, inducing significantly enhanced clearance in ..
- Fluorescence "in situ" hybridization for the detection of biofilm in the middle ear and upper respiratory tract mucosa
Laura Nistico
Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
Methods Mol Biol 493:191-213. 2009
..microscopy (CLSM)-based 16S rRNA fluorescence in situ hybridization (FISH) protocol, to find biofilm bacteria in middle ear and upper respiratory tract mucosa, which preserves the three-dimensional structure of the biofilm and avoids ..
- Chinchilla middle ear epithelial mucin gene expression in response to inflammatory cytokines
Joseph E Kerschner
Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Arch Otolaryngol Head Neck Surg 130:1163-7. 2004
..importance of mucin on a molecular level in the understanding of the pathophysiology of otitis media and to present new data demonstrating differential up-regulation of specific mucin genes during inflammation of middle ear epithelium.
- External and middle ear status related to evoked otoacoustic emission in neonates
K W Chang
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle
Arch Otolaryngol Head Neck Surg 119:276-82. 1993
..The purpose of this study was to determine the relationship between external auditory canal and middle ear status with click-evoked OAE...
- Differential expression of toll-like receptors 2 and 4 in rat middle ear
Jae Jun Song
Department of Otorhinolaryngology Head and Neck Surgery, Dongguk University International Hospital, Gyeonggi, South Korea
Int J Pediatr Otorhinolaryngol 73:821-4. 2009
The epithelial cells of the middle ear and Eustachian tube must maintain an adequate mucosal defense system against various antigenic stimuli...
- Autoregulation of human inner ear blood flow during middle ear surgery with propofol or isoflurane anesthesia during controlled hypotension
M P Preckel
Service d Anesthesie Reanimation, Centre Hospitalier Universitaire, Angers, France
Anesth Analg 87:1002-8. 1998
We used controlled hypotension to obtain a bloodless cavity during middle ear surgery under an optical microscope...
- Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
Joseph Jurcisek
Center for Microbial Pathogenesis, Columbus Children's Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children's Drive, Rm. W591, Columbus, OH 43205-2696, USA
Infect Immun 73:3210-8. 2005
..NTHI forms biofilms in vitro as well as in the chinchilla middle ear, suggesting that biofilm formation in vivo might play an important role in the pathogenesis and chronicity of OM...
- Carbon dioxide exchange via the mucosa in healthy middle ear
F Ikarashi
Department of Otolaryngology, The Nippon Dental University School of Dentistry at Niigata, Japan
Arch Otolaryngol Head Neck Surg 125:975-8. 1999
Recent studies have shown that gas exchange via the middle ear mucosa, which is performed between the middle ear cleft and capillaries in the submucosal connective tissue, has an essential role in ventilation and pressure regulation in ..
- Pressure changes in the human middle ear without opening the eustachian tube
Hans Wilhelm Pau
ENT Department, Medical School, University of Rostock, Doberaner Strasse 137 9, Rostock, Germany
Acta Otolaryngol 129:1182-6. 2009
By means of a direct, though non-invasive experiment on healthy humans we could demonstrate that middle ear (ME) pressure decreases when the eustachian tube (ET) does not open...
- Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion
Mohamed Nasser Elsheikh
Department of Otolaryngology, Tanta University, Egypt
Laryngoscope 116:365-9. 2006
..We investigated the expression of MUC5AC and MUC5B mucin gene messenger (m)RNAs in middle ear effusions as well as in tissue biopsies of the respiratory mucosa of the nasopharynx by means of reverse-..
- Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
Muneki Hotomi
Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
J Clin Microbiol 46:3808-10. 2008
Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains...
- Middle ear influence on otoacoustic emissions. I: noninvasive investigation of the human transmission apparatus and comparison with model results
P Avan
Laboratoire de biophysique sensorielle EA 2667, Faculte de Medecine, Universite d Auvergne, Clermont Ferrand, France
Hear Res 140:189-201. 2000
..and they can be acoustically detected in the external auditory meatus after backward propagation through the middle ear. In addition to being used to probe the cochlear mechanisms, they are expected to be sensitive to minute changes ..
- Recent advances in otitis media. 2. Eustachian tube, middle ear, and mastoid anatomy; physiology, pathophysiology, and pathogenesis
Charles D Bluestone
Department of Otolaryngology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pennsylvania, USA
Ann Otol Rhinol Laryngol Suppl 194:16-30. 2005
- Effects of sevoflurane and TIVA with propofol on middle ear pressure
Ozcan Ozturk
University of Abant Izzet Baysal, Duzce Faculty of Medicine, Department of Otorhinolaryngology, Head and Neck Surgery, Duzce, Turkey
Int J Pediatr Otorhinolaryngol 70:1231-4. 2006
To evaluate the effects of sevoflurane and TIVA with propofol on middle ear pressure and to show the importance of anesthesia without using any inhalational agents during middle ear surgery.
- Eosinophil chemoattractants in the middle ear of patients with eosinophilic otitis media
Y Iino
Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan
Clin Exp Allergy 35:1370-6. 2005
..associated with bronchial asthma have an extensive accumulation of eosinophils in the effusion and mucosa of the middle ear; this condition is called eosinophilic otitis media (EOM)...
- Isolation of measles virus from middle ear fluid of infants with acute otitis media
Hisakazu Yano
Department of Otolaryngology, Tohoku Rosai Hospital, Aoba ku, Sendai 981 8563, Japan
J Infect 51:e237-40. 2005
Measles virus was isolated from the middle ear fluid (MEF) of two infant cases of acute otitis media (AOM) associated with measles...
- Hag directly mediates the adherence of Moraxella catarrhalis to human middle ear cells
Brian Bullard
Department of Medical Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Ave, Health Education Bldg, Rm. 267, Toledo, OH 43614, USA
Infect Immun 73:5127-36. 2005
..with a spectinomycin resistance cassette, and the binding of isogenic mutants to primary cultures of human middle ear epithelial cells (HMEE), as well as A549 pneumocytes, was measured...
- Neuroendocrine adenoma of the middle ear
Lester D R Thompson
Department of Pathology, Woodland Hills Medical Center, Southern California Permanente Medical Group, Woodland Hills, CA, USA
Ear Nose Throat J 84:560-1. 2005
- Middle ear pressure changes during anesthesia with or without nitrous oxide are similar among airway devices
Mathias Hohlrieder
Department of Anaesthesia and Intensive Care Medicine, Leopold-Franzens University, Innsbruck, Austria
Anesth Analg 102:319-21. 2006
We tested the hypothesis that middle ear pressure (MEP) is influenced by the choice of airway device during anesthesia with or without nitrous oxide (N2O) in the gas mixture...
- Tetrapod-like middle ear architecture in a Devonian fish
Martin D Brazeau
Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Evolutionary Biology Centre, Uppsala University, Norbyv 18A, SE 752 36 Uppsala, Sweden
Nature 439:318-21. 2006
..in the remodelling of the spiracular tract and suspensorium (jaw suspension) of osteolepiform fishes into the middle ear of tetrapods have remained elusive...
- Comparison of multidetector row CT cross-sectional source images with multiplanar 2D-, 3D- reconstructions and virtual endoscopy in assessment of the middle ear
A Trojanowska
J Neuroradiol 33:277-8. 2006
- Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
Sung Kyun Moon
The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
BMC Infect Dis 6:12. 2006
..transcription of beta-defensin 2 (DEFB4 according to new nomenclature of the Human Genome Organization) in human middle ear epithelial cells via a Src-dependent Raf-MEK1/2-ERK signaling pathway...
- Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution
Abigail S Tucker
Department of Craniofacial Development and Orthodontics, Kings College London, Floor 28, Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Development 131:1235-45. 2004
The middle ear apparatus is composed of three endochondrial ossicles (the stapes, incus and malleus) and two membranous bones, the tympanic ring and the gonium, which act as structural components to anchor the ossicles to the skull...
- Carcinoid tumor of the middle ear: clinical features, recurrences, and metastases
Mitchell J Ramsey
Division of Otolaryngology, Tripler Army Medical Center, Honolulu, HI, USA
Laryngoscope 115:1660-6. 2005
OBJECTIVE: Present four new cases of carcinoid tumor of the middle ear, two of which developed late recurrences and regional metastases...
- Neonatal middle ear effusion predicts chronic otitis media with effusion
Karen Jo Doyle
University of California Davis Medical Center, Sacramento, California, USA
Otol Neurotol 25:318-22. 2004
The specific aims of the research are to determine whether newborn ears with persistent middle ear effusion at age 30 to 48 hours are more likely to develop chronic otitis media with effusion over the first year of life when compared with ..
- The presence of platelet-activating factor-acetylhydrolase in human middle ear effusions
H Tsuji
Department of Otolaryngology, Kansai Medical University, Osaka, Japan
ORL J Otorhinolaryngol Relat Spec 60:25-9. 1998
..We have obtained evidence that PAF-AH activity is present in human middle ear effusions in patients with chronic otitis media with effusion...
- Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature
Kevin R Torske
Department of Endocrine and Otorhinolaryngic-Head and Neck Pathology, Armed Forces Institute of Pathology, Washington, D.C
Mod Pathol 15:543-55. 2002
Carcinoid tumors and adenomas of the middle ear are rare neoplasms of indeterminate relationship to one another...
- Smoking and tympanoplasty: implications for prognosis and the Middle Ear Risk Index (MERI)
Z Becvarovski
Michigan Ear Institute, Farmington Hills, Michigan, USA
Laryngoscope 111:1806-11. 2001
The objectives of this study are to review the effects of smoking on preoperative middle ear disease severity, long-term surgical outcome, type and extent of surgery required, the need for ossicular chain reconstruction, and the long-term ..
- Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrB and rfaD mutants
H H Tong
Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA
Infect Immun 69:3678-84. 2001
..compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cell cytokine and chemokine gene expression and production in vitro...
- Control of symptoms in patients with Meniere's disease using middle ear pressure applications: two years follow-up
B Densert
City Clinics, Otology Unit, General Hospital, Halmstad, Sweden
Acta Otolaryngol 121:616-21. 2001
The effects of middle ear pressure pulses were studied in 37 patients with a diagnosis of definite Meniere's disease and active vestibular symptoms, 31 of whom had failed to respond to medical treatment including diuretics prior to ..
- Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium
M Mallo
Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
Development 127:4127-36. 2000
..Vibrations in this membrane are then transduced into the inner ear by the ossicle chain of the middle ear, composed of the malleus, incus and stapes...
- Carcinoid tumor of the middle ear: report of a case
Murat Sahan
Department of Otolaryngology, Ankara Military Hospital, Ankara, Turkey
Am J Otolaryngol 29:352-6. 2008
Carcinoid tumor of the middle ear is an extremely rare lesion of the middle ear, and thus its diagnosis is frequently delayed. Some authors found it hard to differentiate middle ear carcinoid from the middle ear adenoma...
- Scaling of the cetacean middle ear
S Nummela
University of Helsinki, Department of Ecology and Systematics, Finland
Hear Res 133:71-81. 1999
..The mean ossicular density is 2.64 g/cm3 for odontocetes, and 2.35 g/cm3 for mysticetes. The highly mineralized and convex tympanic plate provides cetaceans with a uniquely large and stiff sound collecting area...
- The anatomy of the killer whale middle ear (Orcinus orca)
S Nummela
University of Helsinki, Department of Ecology and Systematics, Finland
Hear Res 133:61-70. 1999
..The ossicles in the air-filled middle ear cavity form a bridge from the tympanic plate to the periotic bone connecting the vibrating plate to the oval ..
- Killed whole bacterial cells, a mucosal delivery system for the induction of immunity in the respiratory tract and middle ear: an overview
J M Kyd
Gadi Research Centre, Faculty of Applied Science, University of Canberra, ACT, Australia
Vaccine 17:1775-81. 1999
..sub-network in the development of oral vaccine strategies for infections of the respiratory tract and middle ear. Mucosal immunization with whole formalin killed Pseudomonas aeruginosa (Pa), Branhamella catarrhalis, ..
- The neonate has a temporary conductive hearing loss due to fluid in the middle ear
R Priner
Department of Physiology, Hebrew University - Hadassah Medical School, Jerusalem, Israel
Audiol Neurootol 8:100-10. 2003
..On the day of birth there were signs of a conductive hearing loss: negative middle ear pressure, auditory nerve brainstem evoked response (ABR) threshold elevation, ABR wave 1 latency prolongation ..
- Adhesin expression in matched nasopharyngeal and middle ear isolates of nontypeable Haemophilus influenzae from children with acute otitis media
G P Krasan
Edward Mallinckrodt Department of Pediatrics and Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
Infect Immun 67:449-54. 1999
..colonization and localized respiratory tract disease, we assessed their expression in matched nasopharyngeal and middle ear isolates of nontypeable H. influenzae from 17 children with acute otitis media...
- Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma
Giovanni Cristalli
Department of Otolaryngology, Head and Neck Surgery, National Cancer Institute Regina Elena, Rome, Italy
J Craniofac Surg 20:816-21. 2009
..Disease-free survival was 73.3%, and overall survival was 75.6%. Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome...
- Feedback control of the auditory periphery: anti-masking effects of middle ear muscles vs. olivocochlear efferents
M C Liberman
Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, USA
J Commun Disord 31:471-82; quiz 483; 553. 1998
..It does not improve masked thresholds, but can improve the detectability of small suprathreshold intensity increments. Anti-masking effects of both MEM and MOC systems should be reduced in cases of sensorineural hearing loss...
- Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: the pathological basis for mucin hyperproduction in mucoid otitis media
Hirokazu Kawano
University of Minnesota Otitis Media Research Center, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, USA
Ann Otol Rhinol Laryngol 111:415-22. 2002
..of the leading causes of acquired hearing loss in children, is characterized by mucous cell hyperplasia in the middle ear cleft associated with mucin accumulation in the middle ear cavity...
- Mucoepidermoid carcinoma arising from the eustachian tube and middle ear
Young Ho Kim
Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
J Laryngol Otol 117:202-4. 2003
We report a case of mucoepidermoid carcinoma (MEC) originating from the eustachian tube and middle ear. A 31-year-old male who presented with otorrhoea and methicillin-resistant Staphylococcus aureus (MRSA) in the right ear was admitted ..
- Anomalies of the middle and inner ear
Kimsey Rodriguez
Department of Otolaryngology Head and Neck Surgery, Tulane University School of Medicine, New Orleans, LA, USA
Otolaryngol Clin North Am 40:81-96, vi. 2007
..This process, along with development of the middle ear, continues throughout gestation...
- Ultrastructural morphology of a middle ear ceruminoma
Peter Schenk
Department of Otorhinolaryngology, Vienna Medical School, Wahringer Gurtel 18 20, A 1090 Vienna, Vienna, Austria
ORL J Otorhinolaryngol Relat Spec 64:358-63. 2002
The ultrastructural morphology of a ceruminous gland adenoma in the middle ear was examined electron microscopically...
- Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
Jae Hyang Lim
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 2:e1032. 2007
..Our data demonstrated that CYLD is induced by NTHi in the middle ear and lung of mice...
- The effects of childhood otitis media on the acoustic reflex threshold at age 15
David Welch
Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Int J Audiol 45:353-9. 2006
..This appeared to have an effect independent of audiometric threshold. Furthermore, only those who suffered the worst, persistent, binaural childhood otitis media showed raised acoustic reflex thresholds...
- [Recommendations for treatment of retraction pockets]
Andreas Neumann
Laryngorhinootologie 86:92-4. 2007
- Mechanical obstruction of the eustachian tube by the benign tumor of the parapharyngeal space does not cause otitis media with effusion
Takuro Sumi
Department of Otolaryngology, Tokyo Medical and Dental University, Bunkyo ku, Yushima 1 5 45, Tokyo 113 8519, Japan
Otol Neurotol 28:1072-5. 2007
We are reporting on eustachian tube and middle ear pathologic findings in patients with parapharyngeal tumors.
- Evolution of middle ear changes after permanent eustachian tube blockage
Javier Vicente
Department of Otorhinolaryngology, University Hospital Puerta de Hierro, Calle de San Martín de Porres 4, 28035 Madrid, Spain
Arch Otolaryngol Head Neck Surg 133:587-92. 2007
..To develop a valid animal model for otitis media with effusion (OME)...
- [Evaluation of tympanometric alterations in patients subject to general anesthesia with nitrous oxide]
Fernanda Mossumez Fernandes Teixeira
Universidade Federal do Rio de Janeiro
Rev Bras Otorrinolaringol (Engl Ed) 71:274-80. 2005
..and tympanic graft lateralization after tympanoplasty, in addition to serous fluid entrance into the middle ear during the negative pressure phase...
- Anti-adhesive properties of polytetrafluoroethylene (Gore-Tex) in middle ear surgery. An experimental study
Javier Vicente
Grupo de Investigación Otológica, Servicio de Otorrinolaringologia, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, Madrid, Spain
Acta Otolaryngol 126:144-8. 2006
Polytetrafluoroethylene (PTFE) may represent a material that prevents adhesions when implanted in the middle ear. This characteristic can be used to improve the design of prostheses.
- Liposarcoma of temporal bone: a case report
Toru Seo
Department of Otolaryngology, Takarazuka Municipal Hospital, 4 5 1, Kohama, Takarazuka, Hyogo 665 0827, Japan
Auris Nasus Larynx 34:511-3. 2007
..Neither local recurrence nor distant metastasis has been detected for 24 months after the first surgery. The favorable outcome in this patient was probably due to the histological type of his liposarcoma...
- Acute mastoiditis in children: susceptibility factors and management
Slobodan Spremo
Clinic for Otorhinolaryngology, Clinic Center in Banja Luka, Zdrave Korde 1, 78000 Banja Luka, Bosnia and Herzegovina
Bosn J Basic Med Sci 7:127-31. 2007
..We observed clinical profile of acute mastoiditis in regard to pathology found on the tympanic membrane, middle ear mucosa and destructions on the bony wall of the middle ear and mastoid...
- Embryonal rhabdomyosarcoma of the temporal bone
Borlingegowda Viswanatha
ENT Department, Victoria Hospital, Bangalore Medical College, Bangalore, Karnataka, India
Ear Nose Throat J 86:218, 220-2. 2007
..Despite surgery and chemotherapy, the patient died of his disease within 3 months of presentation...
- Non-ossicular signal transmission in human middle ears: Experimental assessment of the "acoustic route" with perforated tympanic membranes
Susan E Voss
Picker Engineering Program, Smith College, 51 College Lane, Northampton, Massachusetts 01063, USA
J Acoust Soc Am 122:2135-53. 2007
..Some features of the frequency dependence of H(P(CAV) ) and H(WPD) can be interpreted in terms of a structure-based lumped-element acoustic model of the perforation and middle-ear cavities...
- Possible role of Helicobacter pylori in the etiopathogenesis of chronic otitis media
Ahmet Kutluhan
Department of Otorhinolaryngology, School of Medicine, Yuzuncu Yil University, Van, Turkey
Otol Neurotol 26:1125-7. 2005
..To investigate a possible contribution from Helicobacter pylori to the etiopathogenesis of chronic otitis media...
- [Otologic sequels in velopalatine clefts. Analysis and management]
C Paquot-Le Brun
Service d ORL et de chirurgie cervicofaciale, CHU de Côte de Nacre, 14000 Caen, France
Rev Stomatol Chir Maxillofac 108:357-68. 2007
....
- Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching tool
Haobing Wang
Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 27:452-7. 2006
..To develop a three-dimensional virtual model of a human temporal bone based on serial histologic sections...
- [Tensometry - concept and first results of a new technique for measuring the tube function via highly flexible foil strain gauges]
T Zehlicke
, Bundeswehrkrankenhaus Hamburg, Hamburg
Laryngorhinootologie 87:542-5. 2008
- Correlation between middle-ear pressure-regulation functions and outcome of type-I tympanoplasty
Haruo Takahashi
Department of Otolaryngology, Head and Neck Surgery, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1 7 1, Nagasaki 852 8501, Japan
Auris Nasus Larynx 34:173-6. 2007
..To examine the correlation between the middle-ear pressure-regulation functions including active eustachian tube (ET) functions and transmucosal gas exchange function, and outcome of tympanoplasty...
- Laser interferometry measurements of middle ear fluid and pressure effects on sound transmission
Rong Z Gan
School of Aerospace and Mechanical Engineering and Bioengineering Center University of Oklahoma, Norman, Oklahoma 73019, USA
J Acoust Soc Am 120:3799-810. 2006
..By measuring the displacement of the stapes from the medial side of the footplate, the transfer function of the middle ear, which is defined as the displacement transmission ratio (DTR) of the tympanic membrane to footplate, was ..
- Transient facial palsy in two cases of benign, very rare middle ear tumors (carcinoid tumor and myxoma)
Thorsten Zehlicke
Department of Otorhinolaryngology, Head and Neck Surgery Otto Koerner, University of Rostock, Rostock, Germany
Neurologist 14:52-5. 2008
Presentation of the clinical features of 2 very rare middle ear tumors in which the guiding symptom was facial palsy.
- Multifield coupled finite element analysis for sound transmission in otitis media with effusion
Rong Z Gan
School of Aerospace and Mechanical Engineering, University of Oklahoma, Norman, Oklahoma 73019, USA
J Acoust Soc Am 122:3527-38. 2007
..The otitis media with effusion was simulated in the model with variable fluid levels in the middle ear. The interfaces among the air, structure, and fluid in the ear canal and middle ear cavity were identified and ..
- Correlations between rapid maxillary expansion (RME) and the auditory apparatus
Andrea Villano
Department of Orthodontics, University of Pisa, Italy
Angle Orthod 76:752-8. 2006
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- Temporal giant cell reparative granuloma: a reappraisal of pathology and imaging features
C Reis
Department of Neuroradiology, Hospital S Joao, Porto, Portugal
AJNR Am J Neuroradiol 27:1660-2. 2006
..Cortical thinning and bone remodeling of the temporal squamous portion were better seen on CT. The patient underwent surgery, and the diagnosis was achieved by the correlation of imaging, histologic, and laboratory findings...
- Combined effect of fluid and pressure on middle ear function
Chenkai Dai
School of Aerospace and Mechanical Engineering and Bioengineering Center, University of Oklahoma, 865 Asp Avenue, Room 200, Norman, OK 73019, United States
Hear Res 236:22-32. 2008
..The aim of this study is to investigate the combined effect of fluid and pressure on middle ear function...
- How to reliably evaluate middle ear diseases? Comparison of different methods of post-processing based on multislice computed tomography examination
A Trojanowska
Department of Radiology, University Medical School of Lublin, Lublin, Poland
Acta Otolaryngol 127:258-64. 2007
..Multislice computed tomography (MSCT) virtual endoscopy was useful in evaluating mainly post-traumatic and postoperative cases. In other pathological conditions axial images and MPR reformations were most useful...
- The middle ear of cleft palate patients in their early teens: a literature study and preliminary file study
K Timmermans
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Belgium
B-ENT 2:95-101. 2006
OBJECTIVES: Middle ear disease is a frequent problem in young children with cleft palate (CP). Less is known about otological status in the adolescent CP population...
- Imaging of the opacified middle ear
M M Lemmerling
Department of Radiology, AZ Sint Lucas Gent, Groenebriel 1, 9000 Gent, Belgium
Eur J Radiol 66:363-71. 2008
b>Middle ear opacification on imaging studies performed in a non-traumatic setting mostly reflects chronic inflammatory/infectious disease. In some of these patients an underlying cholesteatoma will be found...
- Multiple osteomas in the middle ear
Chang Woo Kim
Department of Otorhinolaryngology--Head and Neck Surgery, Hallym University College of Medicine, 445 Gil-dong, Gangdong-gu, Seoul 134-701, Korea
Eur Arch Otorhinolaryngol 263:1151-4. 2006
Osteomas in the middle ear are extremely rare and are generally solitary and small...
- Tuberculous otitis in infants: temporal bone histopathology and clinical extrapolation
Yamileth Nicolau
Pediatric Otolaryngology Service, The Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02115, USA
Otol Neurotol 27:667-71. 2006
The study of infant temporal bones with tuberculosis (TB) of the middle ear and mastoid could provide information to assist with clinical diagnosis in this population.
- Morphological considerations about middle ear cholesteatoma
Nicoleta Măru
Department of Clinical and Topographical Anatomy, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest
Rom J Morphol Embryol 47:73-7. 2006
The aim of this study is to present various morphologic aspects of the middle ear cholesteatoma, concerning both container (tympanic cavity) and content (cholesteatoma)...
- Imaging of hearing loss
Michele B St Martin
Department of Otolaryngology, University of Florida, PO Box 100264, 1600 SW Archer Road M228, Gainesville, FL 32610, USA
Otolaryngol Clin North Am 41:157-78, vi-vii. 2008
..In general, the external auditory canal, middle ear space, mastoid, petrous apex, and otic capsule are best visualized with CT, whereas suspicion of retrocochlear ..
- Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis
Adin Selcuk
4th ENT Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
Laryngoscope 118:697-705. 2008
..This study aimed to evaluate the ability of topically applied calcium channel blockers (diltiazem) to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis...
- Evidence-based review of aetiopathogenic theories of congenital and acquired cholesteatoma
R Persaud
Department of Otolaryngology, Northwick Park Hospital, Harrow, UK
J Laryngol Otol 121:1013-9. 2007
..of cholesteatoma is keratinising stratified squamous epithelium, but the origin of this epidermal tissue in the middle ear is controversial...
- Paraganglioma presenting as chronic otitis media with cholesteatoma: pitfalls and strategies
Jui-Lin Hsu
Department of Otolaryngology, Chang Gung University, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Japan
Am J Otolaryngol 25:190-4. 2004
..There may be radiological characteristics of either cholesteatoma or paraganglioma in the middle ear area, but the diagnosis of the coexistence of the 2 is usually made only postoperatively...
- Tympanic membrane retraction pockets. Etiology, pathogeny, treatment
B M Ars
Temporal Bone Foundation, Brussels, Belgium
Acta Otorhinolaryngol Belg 45:265-77. 1991
..describes the morphological behaviour of the tympanic membrane, undergoing long term negative pressure in the middle ear cavities...
- Hearing deficits in young adults who had a history of otitis media in childhood: use of personal stereos had no effect on hearing
Brechtje A de Beer
Department of Otorhinolaryngology, University Medical Center Nijmegen, Nijmegen, The Netherlands
Pediatrics 111:e304-8. 2003
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- [Clinical analysis of 20 cases of carcinoma of the middle ear]
Xinchun Wang
Department of Otorhinolaryngology, General Hospital of Wuhan University, Wuhan 430060
Lin Chuang Er Bi Yan Hou Ke Za Zhi 17:600-1. 2003
OBJECTIVE: In order to deeply realized the cancer of middle ear, a retrospective analysis of 20 cases was done. METHOD: The combined treatment (operation plus radiation) were adopted for all of them...
- External auditory canal cholesteatoma: clinical and imaging spectrum
Marta E Heilbrun
Department of Radiology, Division of Neuroradiology, University of Utah School of Medicine, Salt Lake City, USA
AJNR Am J Neuroradiol 24:751-6. 2003
..The middle ear cavity, mastoid, facial nerve canal, and tegmen tympani were evaluated for involvement...
- Tympanometry in newborn infants--1 kHz norms
Robert H Margolis
University of Minnesota, Department of Otolaryngology MMC283, Minneapolis, MN 55455, USA
J Am Acad Audiol 14:383-92. 2003
..The pass rate was lower for newborn well babies and NICU graduates who were not screened by OAE (Study 4)...
