endolymphatic sac

Summary

Summary: The blind pouch at the end of the endolymphatic duct.

Top Publications

  1. ncbi Morphological changes of the endolymphatic sac induced by microinjection of artificial endolymph into the cochlea
    H Rask-Andersen
    Department of Otolaryngology, University Hospital Akademiska sjukhuset of Uppsala, 751 85 Uppsala, Sweden
    Hear Res 138:81-90. 1999
  2. ncbi Hearing preservation surgery for small endolymphatic sac tumors in patients with von Hippel-Lindau syndrome
    Cliff A Megerian
    Department of Otolaryngology Head and Neck Surgery, Medical Center, University of Massachusetts Medical School, 55 Lake Avenue, Room S2 861, Worcester, MA 01655, U S A
    Otol Neurotol 23:378-87. 2002
  3. ncbi [Endolymphatic sac tumor and von Hippel-Lindau disease. Review of the literature]
    C De Minteguiaga
    Sanatorio Ntra, Sra del Rosario, Madrid, Espana
    Acta Otorrinolaringol Esp 53:515-20. 2002
  4. pmc Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression
    Hyoung Mi Kim
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 5:e14041. 2010
  5. ncbi Coexpression of erythropoietin and its receptor in endolymphatic sac tumors
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 103:284-8. 2005
  6. ncbi Endolymphatic sac tumor in a 4-year-old boy
    Michael E Kupferman
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Otol Neurotol 25:782-6. 2004
  7. doi Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene
    A Skalova
    Department of Pathology, Medical Faculty of Charles University, Pilsen, Czech Republic
    Pathol Res Pract 204:599-606. 2008
  8. doi Functional and molecular expression of epithelial sodium channels in cultured human endolymphatic sac epithelial cells
    Sung Huhn Kim
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea
    Otol Neurotol 30:529-34. 2009
  9. pmc Origin of endolymphatic sac tumor
    Leslie Michaels
    Department of Histopathology, Royal Free and UCL Medical School, University College London, University Street, London, UK
    Head Neck Pathol 1:104-11. 2007
  10. ncbi Tumors of the endolymphatic sac in von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 350:2481-6. 2004

Research Grants

  1. Regulation of auditory neuron neurite growth by activity
    Marlan Hansen; Fiscal Year: 2007
  2. Modern Studies of the Human Temporal Bone
    Akira Ishiyama; Fiscal Year: 2007
  3. INNER EAR IMMUNE RESPONSES
    Elizabeth Keithley; Fiscal Year: 2002
  4. Potassium Homeostasis in the Inner Ear
    Ebenezer N Yamoah; Fiscal Year: 2010
  5. Recent Advancees in Otitis Media: Research Conference
    David Lim; Fiscal Year: 2003
  6. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2009
  7. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2007
  8. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2010
  9. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2003
  10. Ninth Research Conference on Recent Advances in Otitis Media
    David Lim; Fiscal Year: 2007

Detail Information

Publications187 found, 100 shown here

  1. ncbi Morphological changes of the endolymphatic sac induced by microinjection of artificial endolymph into the cochlea
    H Rask-Andersen
    Department of Otolaryngology, University Hospital Akademiska sjukhuset of Uppsala, 751 85 Uppsala, Sweden
    Hear Res 138:81-90. 1999
    Morphological changes of the endolymphatic sac were analyzed in guinea pigs following microinjection of artificial endolymph into the cochlea or withdrawal of a quantity of native endolymph...
  2. ncbi Hearing preservation surgery for small endolymphatic sac tumors in patients with von Hippel-Lindau syndrome
    Cliff A Megerian
    Department of Otolaryngology Head and Neck Surgery, Medical Center, University of Massachusetts Medical School, 55 Lake Avenue, Room S2 861, Worcester, MA 01655, U S A
    Otol Neurotol 23:378-87. 2002
    To determine the incidence of bilateral endolymphatic sac tumors in von Hippel-Lindau syndrome and to describe the technique and results of hearing preservation surgery for small endolymphatic sac tumors in a series of patients with von ..
  3. ncbi [Endolymphatic sac tumor and von Hippel-Lindau disease. Review of the literature]
    C De Minteguiaga
    Sanatorio Ntra, Sra del Rosario, Madrid, Espana
    Acta Otorrinolaringol Esp 53:515-20. 2002
    This report describes a patient with Von Hippel-Lindau disease revealed by an endolymphatic sac tumor. Endolymphatic sac tumor (EST) was only recently recognized as a manifestation of Von Hippel-Lindau (VHL) disease...
  4. pmc Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression
    Hyoung Mi Kim
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 5:e14041. 2010
    ..a malfunction of fluid transport in the connected compartments, which are the vestibular labyrinth and the endolymphatic sac. Embryonic inner ears from Slc26a4(+/-) and Slc26a4(-/-) mice were examined by confocal microscopy ex vivo ..
  5. ncbi Coexpression of erythropoietin and its receptor in endolymphatic sac tumors
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 103:284-8. 2005
    ..The cell of origin and the reason for the particular organ distribution of the tumors remains unknown. Endolymphatic sac tumor (ELST) is one of the lesions associated with VHL disease...
  6. ncbi Endolymphatic sac tumor in a 4-year-old boy
    Michael E Kupferman
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Otol Neurotol 25:782-6. 2004
    b>Endolymphatic sac tumors (ELST) are rare, low-grade, locally aggressive papillary neoplasms. We present a case of a 4-year-old boy with an ELST, the youngest described in the literature.
  7. doi Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene
    A Skalova
    Department of Pathology, Medical Faculty of Charles University, Pilsen, Czech Republic
    Pathol Res Pract 204:599-606. 2008
    b>Endolymphatic sac tumor (Heffner tumor) (ELST) is a very rare nonmetastasizing, locally aggressive low-grade adenocarcinoma of endolymphatic sac origin, which is linked to von-Hippel-Lindau disease (VHLD)...
  8. doi Functional and molecular expression of epithelial sodium channels in cultured human endolymphatic sac epithelial cells
    Sung Huhn Kim
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea
    Otol Neurotol 30:529-34. 2009
    Epithelial sodium channels are expressed in cultured human endolymphatic sac (ES) epithelial (HESE) cells and epithelial sodium channel (ENaC) expression is suppressed by interleukin 1beta.
  9. pmc Origin of endolymphatic sac tumor
    Leslie Michaels
    Department of Histopathology, Royal Free and UCL Medical School, University College London, University Street, London, UK
    Head Neck Pathol 1:104-11. 2007
    ..This is the second literature report confirming the post-mortem site of origin of the "endolymphatic sac tumor"...
  10. ncbi Tumors of the endolymphatic sac in von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 350:2481-6. 2004
  11. ncbi Mechanisms of morbid hearing loss associated with tumors of the endolymphatic sac in von Hippel-Lindau disease
    John A Butman
    Diagnostic Radiology Department, The Clinical Center of the National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 298:41-8. 2007
    b>Endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and cause irreversible sensorineural hearing loss (SNHL) and vestibulopathy...
  12. ncbi Mutation of von Hippel-Lindau tumor suppressor gene in a sporadic endolymphatic sac tumor
    S Hamazaki
    Department of Pathology, Okayama University Hospital, Okayama, Japan
    Hum Pathol 32:1272-6. 2001
    b>Endolymphatic sac tumor (ELST) is a low-grade adenocarcinoma of the temporal bone that is presumed to originate from the endolymphatic system...
  13. doi Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): sine qua non radiology-pathology and the University of Texas MD Anderson Cancer Center experience
    Diana Bell
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Ann Diagn Pathol 15:117-23. 2011
    b>Endolymphatic sac tumor (ELST) is a rare lesion of the skull base for which the origin has recently been ascertained...
  14. doi von Hippel-Lindau disease: surveillance strategy for endolymphatic sac tumors
    Marie Louise Mølgaard Poulsen
    Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
    Genet Med 13:1032-41. 2011
    Up to 16% of patients with the hereditary von Hippel-Lindau disease develop endolymphatic sac tumors of the inner ear...
  15. pmc Endolymphatic sac tumor: case report and review of the literature
    Yan Hua Sun
    Department of Pathology, Shenzhen Second People s Hospital, 3002 Sungang West Road, Shenzhen 518035, China
    Diagn Pathol 7:36. 2012
    b>Endolymphatic sac tumor (ELST) is a rare neoplasm which can be encountered sporadically or in Von Hippel-Lindau (VHL) disease. Here we report a sporadic case of ELST in 31-year-old man...
  16. ncbi Endolymphatic sac tumors in von Hippel-Lindau disease
    Daniel Choo
    Neuro Otology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 100:480-7. 2004
    Von Hippel-Lindau (VHL) disease is a hereditary multiple-neoplasia syndrome mapping to chromosome 3p25-26. Endolymphatic sac (ELS) tumors have been identified as a neoplastic manifestation of VHL disease...
  17. ncbi Quantitative anatomy of the guinea pig endolymphatic sac
    Kelli Pettit
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 174:1-8. 2002
    The endolymphatic sac is believed to represent one of the primary loci for endolymph volume regulation in the inner ear...
  18. doi Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors
    Jens Schittenhelm
    Dept of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Am J Clin Pathol 138:85-9. 2012
    The endolymphatic sac tumor (ELST) is a low-grade carcinoma originating in the ear. These extremely rare tumors are capable of invading the cerebellopontine angle and might be mistaken for choroid plexus tumors (CPTs) in this region...
  19. ncbi Obstructing lesions of the endolymphatic sac and duct mimicking Ménière's disease
    Ryan C Cmejrek
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Ear Nose Throat J 83:753-6. 2004
    ..retrospective case series and literature review, we demonstrate that temporal bone lesions that obstruct the endolymphatic sac or duct can cause symptoms of Ménière's disease...
  20. ncbi Differential grading of endolymphatic sac tumor extension by virtue of von Hippel-Lindau disease status
    Nicholas C Bambakidis
    Department of Neurological Surgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Otol Neurotol 25:773-81. 2004
    b>Endolymphatic sac tumors are aggressive papillary tumors of the temporal bone frequently associated with von Hippel-Lindau disease...
  21. ncbi Intratympanic gentamicin treatment after endolymphatic sac surgery
    Haralampos Gouveris
    Department of Otolaryngology Head and Neck Surgery, University of Mainz Medical School, Mainz, Germany
    Acta Otolaryngol 125:1180-3. 2005
    ..Interval treatment with up to three intratympanic gentamicin injections once weekly effectively controlled vertigo while preserving hearing in patients with Ménière's disease and recurrent or resistant vertigo after saccotomy...
  22. ncbi Large vestibular aqueduct syndrome: a human temporal bone study
    Shigeo Hirai
    International Hearing Foundation, Minneapolis, Minnesota, USA
    Laryngoscope 116:2007-11. 2006
    ..This study was undertaken to determine prevalence of LVAS in our temporal bone (TB) collection and its relationship to other systemic or otologic anomalies...
  23. ncbi 10-year review of endolymphatic sac surgery for intractable meniere disease
    Amanda Hu
    Department of Otolaryngology, University of Western Ontario, London, Ontario
    J Otolaryngol Head Neck Surg 39:415-21. 2010
    To review our 10-year experience of endolymphatic sac surgery (ESS) for intractable Meniere disease (MD).
  24. ncbi Imaging and clinical findings in large endolymphatic duct and sac syndrome
    Sabrina Koesling
    University of Halle, Department of Radiology, Halle, Germany
    Eur J Radiol 57:54-62. 2006
    ..The aim of this study was to evaluate the incidence of LEDS in the own patient population and to present our experiences regarding imaging findings, clinical presentation and follow up...
  25. pmc Localization and functional studies of pendrin in the mouse inner ear provide insight about the etiology of deafness in pendred syndrome
    Ines E Royaux
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Assoc Res Otolaryngol 4:394-404. 2003
    ..cells of the cristae ampullaris, utriculi, and sacculi as well as in the apical membrane of cells in the endolymphatic sac. Pds-knockout (Pds-/-) mice were found to lack pendrin immunoreactivity in all of these locations...
  26. pmc Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti
    Isolde Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Electrophoresis 27:1598-608. 2006
    ..First, we demonstrate how quick-freezing and freeze drying prevents artifacts that arise from sampling endolymphatic sac (ES) content in the liquid state...
  27. ncbi Endolymphatic sac tumours: surgical management
    Jörg Schipper
    Department of Head and Neck Surgery, University of Freiburg, Freiburg, Germany
    J Otolaryngol 35:387-94. 2006
    b>Endolymphatic sac tumours (ELSTs) have been known as an individual tumour entity only since 1984. ELSTs may occur either solitarily and sporadically or as a hereditary manifestation associated with von Hippel-Lindau (VHL) disease...
  28. doi Expression of aquaporin1, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac
    Akinobu Kakigi
    Department of Otolaryngology, Kochi Medical School, Nankoku, Japan
    Auris Nasus Larynx 36:135-9. 2009
    To locate aquaporin (AQP) 1, 3, and 4, Na-K-2Cl cotransporter (NKCC) 1 and 2 in the human endolymphatic sac (ES).
  29. ncbi Soluble megalin is accumulated in the lumen of the rat endolymphatic sac
    Tetsuya Ishida
    Department of Histology and Cell Biology, School of Medicine, Kagawa University, Miki, Kagawa 761 0793, Japan
    Cell Struct Funct 31:77-85. 2006
    The endolymphatic sac (ES) is believed to play an important role in maintaining homeostasis in the inner ear by the absorption and endocytosis of endolymph...
  30. ncbi Endolymphatic sac decompression as a treatment for Meniere's disease
    William F Durland
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, U S A
    Laryngoscope 115:1454-7. 2005
    b>Endolymphatic sac decompression is a surgical treatment option for patients with medically intractable Meniere's disease. However, effectiveness is debated because published data show great variability...
  31. ncbi Variations in surgical anatomy of the endolymphatic sac
    U Friberg
    Department of Otolaryngology, Akademiska sjukhuset, Uppsala, Sweden
    Arch Otolaryngol Head Neck Surg 114:389-94. 1988
    Twenty-nine specimens of the extraosseous portion of the human endolymphatic sac (ES) were serially sectioned longitudinally. The length and width of the extraosseous ES were measured and the surface area was calculated...
  32. doi Expression and translocation of aquaporin-2 in the endolymphatic sac in patients with Meniere's disease
    C Maekawa
    Department of Otolaryngology, Osaka University, School of Medicine, Suita City, Osaka, Japan
    J Neuroendocrinol 22:1157-64. 2010
    ..that both plasma stress hormone, vasopressin (pAVP) and its receptor, V2 (V2R) expression in the inner ear endolymphatic sac were significantly higher in Meniere's patients...
  33. ncbi Up-regulation of cochlear aquaporin-3 mRNA expression after intra-endolymphatic sac application of dexamethasone
    Tadashi Kitahara
    Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurol Res 25:865-70. 2003
    The final aim of the present study is to see if the endolymphatic sac is really available as a drug delivery system to have effect on the inner ear organs...
  34. pmc Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation
    Hitoshi Satoh
    Division of Otolaryngology Head and Neck Surgery, University of California, San Diego, CA 92093, USA
    J Assoc Res Otolaryngol 4:139-47. 2003
    ..The role of the endolymphatic sac in this immune process is not clear...
  35. ncbi Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac
    Hongwei Dou
    Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Histochem Cytochem 52:1377-84. 2004
    The endolymph in the endolymphatic sac (ES) is acidic (pH 6.6-7). Maintaining this acidic lumen is believed to be important for the normal function of the ES. The acid-base regulation mechanisms of the ES are unknown...
  36. doi Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells
    Eun Jin Son
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea
    J Cell Biochem 107:965-72. 2009
    ..We determined the functional and molecular expression of NHEs in cultured human endolymphatic sac (ES) epithelial cells and examined the effect of IFN-gamma on NHE function...
  37. ncbi Changes in ultrastructural characteristics of endolymphatic sac ribosome-rich cells of the rat during development
    Theo A Peters
    Department of Otorhinolaryngology, University Medical Center St Radboud, Philips van Leydenlaan 15, 6500 HB Nijmegen, The Netherlands
    Hear Res 176:94-104. 2003
    It has recently been demonstrated that endolymphatic sac (ES) ribosome-rich (dark) cells respond to induced endolymph changes and are thus likely to be involved in endolymph homeostasis...
  38. ncbi DAN directs endolymphatic sac and duct outgrowth in the avian inner ear
    Lisa M Gerlach-Bank
    Department of Cell and Developmental Biology, Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Dev Dyn 229:219-30. 2004
    ....
  39. ncbi Developmental and cellular expression pattern of epithelial sodium channel alpha, beta and gamma subunits in the inner ear of the rat
    S Grunder
    Department of Otolaryngology, Division of Sensory Biophysics, Röntgenweg 11, D 72076 Tubingen, Germany
    Eur J Neurosci 13:641-8. 2001
    ..mRNA for the three channel-forming subunits (alpha, beta and gamma ENaC) in cochlea, vestibular system and endolymphatic sac. mRNA abundance increased during the first 12 days of life in cochlea and vestibular system, coinciding with ..
  40. ncbi Long-term follow-up of hearing loss in children and young adults with enlarged vestibular aqueducts: relationship to radiologic findings and Pendred syndrome diagnosis
    Ian B Colvin
    Department of Paediatric Audiovestibular Medicine, Royal National Throat, Nose and Ear Hospital, London, United Kingdom
    Laryngoscope 116:2027-36. 2006
    ..between the hearing loss (HL) and the dimensions of the EVA, enlarged endolymphatic duct (EED), or enlarged endolymphatic sac (EES) was also investigated...
  41. ncbi Stereocilia-like structures in the endolymphatic sac in Ménière's disease and acoustic neuroma
    N Danckwardt-Lillieström
    Department of Otolaryngology, Head and Neck Surgery, University Hospital, Uppsala, Sweden
    ORL J Otorhinolaryngol Relat Spec 60:190-7. 1998
    ..Stereocilia-like structures were found in the luminal contents of the endolymphatic sac (ES) in all of these patients. The ES from 18 patients with acoustic neuroma were used as controls...
  42. ncbi Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease
    S Richard
    Laboratoire de génétique oncologique Ephe, CHU de Bicetre, Le Kremlin Bicetre, France
    Neurosurg Rev 23:1-22; discussion 23-4. 2000
    ..in patients with a VHL-related tumor without familial history and especially in case of hemangioblastoma or endolymphatic sac tumors...
  43. ncbi Expression of inducible nitric oxide synthase in the cochlea following immune response in the endolymphatic sac of guinea pigs
    K Watanabe
    Department of Oto-Rhino-Laryngology, Nippon Medical School, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 63:155-9. 2001
    ..in the cochlea of guinea pigs was performed after the injection of keyhole limpet hemocyanin (KLH) into the endolymphatic sac. Morphological changes were observed in the cochlea of all animals after the injection of KLH...
  44. ncbi Effect of locally applied drugs on the endolymphatic sac potential
    V Couloigner
    INSERM U 426, the Faculté Xavier Bichat, University of Paris 7, France
    Laryngoscope 108:592-8. 1998
    ..disease, an inner ear disorder related to an endolymphatic hydrops, an alteration of the functioning of the endolymphatic sac has been proposed. The endolymphatic sac is assumed to be involved in the secretion/resorption of endolymph...
  45. ncbi Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner ear
    K M Stankovic
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Hear Res 114:21-34. 1997
    ..staining for the Cl-/HCO3- exchanger; these included interdental cells and epithelial cells of the endolymphatic sac. Cochlear cell types with diffuse cytoplasmic staining for vH+ATPase and a basolaterally localized Cl-/HCO3- ..
  46. ncbi [Changes in plasma inner ear hormones after endolymphatic sac drainage and steroid-instillation surgery (EDSS)]
    Tadashi Kitahara
    Department of Otolaryngology, Osaka University, Osaka
    Nihon Jibiinkoka Gakkai Kaiho 105:557-63. 2002
    We treated 33 cases of intractable Meniere's disease with endolymphatic sac drainage and steroid-instillation surgery (EDSS), attaining good long-term results in vertigo and hearing...
  47. ncbi Endolymphatic sac surgery for Meniere's disease: experience with over 3000 cases
    Tsun Sheng Huang
    Department of Otolaryngology Head and Neck Surgery, Chang Gung University School of Medicine, Chang Gung Memorial Hospital, 199 Tung Hwa North Road Taipei, Taipei, Taiwan, Republic of China
    Otolaryngol Clin North Am 35:591-606. 2002
    ....
  48. ncbi Topical mitomycin C and cephalosporin in endolymphatic sac surgery
    Tsun Sheng Huang
    Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Laryngoscope 112:243-7. 2002
    To determine whether intraoperative topical application of the drug mitomycin C to the endolymphatic sac area in conjunction with endolymphatic sac ballooning surgery (ESBS) can safely achieve longer-lasting relief from incapacitating, ..
  49. ncbi Responses of the endolymphatic sac to perilymphatic injections and withdrawals: evidence for the presence of a one-way valve
    Alec N Salt
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 191:90-100. 2004
    Although the endolymphatic sac (ES) is thought to be a primary site for endolymph volume regulation, we have limited knowledge of how it responds to volume and pressure changes...
  50. ncbi Evaluating quality of life after endolymphatic sac surgery: The Ménière's Disease Outcomes Questionnaire
    B Maya Kato
    Department of Head and Neck Surgery, Kaiser Permanente Medical Center, Union City, California 94587, USA
    Otol Neurotol 25:339-44. 2004
    To develop a disease-specific instrument to measure the quality of life in patients with Ménière's disease and to assess quality-of-life outcomes after endolymphatic sac decompression.
  51. ncbi Endolymphatic sac surgery for Meniére's disease. A cumulative study of twelve years' experience
    T S Huang
    Department of Otolaryngology, Chang Gung Medical College, Taipei, Taiwan, Republic of China
    Acta Otolaryngol Suppl 485:145-54. 1991
    ..This not only accentuates the efficacy of revision surgery, but opens new areas of investigation into the underlying etiology of this elusive disease...
  52. doi An unusual presentation and spread of an endolymphatic sac tumor
    Daniel H Coelho
    Department of Otolaryngology, NYU School of Medicine, New York, New York, USA
    Otol Neurotol 29:569-70. 2008
  53. pmc The vestibular aqueduct: site of origin of endolymphatic sac tumors
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 108:751-6. 2008
    Although endolymphatic sac tumors (ELSTs) frequently destroy the posterior petrous bone and cause hearing loss, the anatomical origin of these neoplasms is unknown...
  54. ncbi Tumors of the endolymphatic sac in patients with von Hippel-Lindau disease: implications for their natural history, diagnosis, and treatment
    H Jeffrey Kim
    Neuro Otology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 102:503-12. 2005
    b>Endolymphatic sac tumors (ELSTs), which often are associated with von Hippel-Lindau (VHL) disease, cause irreversible hearing loss and vestibulopathy...
  55. ncbi Local overpressure treatment reduces vestibular symptoms in patients with Meniere's disease: a clinical, randomized, multicenter, double-blind, placebo-controlled study
    Jens Thomsen
    Department of Otolaryngology Head and Neck Surgery, Gentofte University Hospital, Hellerup, Denmark
    Otol Neurotol 26:68-73. 2005
    ..2 kPa, the pressure oscillates between 0.4 and 1.2 kPa. It is believed that the pressure changes are conveyed to the inner ear, inducing a transport of fluids via the pressure outlets and thus reducing the endolymphatic hydrops...
  56. ncbi Surgical treatment of endolymphatic sac tumor with adjunctive stereotactic radiation therapy--case report
    Masanori Hashimoto
    Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Neurol Med Chir (Tokyo) 44:595-9. 2004
    A 44-year-old man presented with an endolymphatic sac tumor (ELST) associated with von Hippel-Lindau disease, which required four surgical procedures within 10 years...
  57. ncbi Endolymphatic sac tumor
    Anirvan Banerjee
    Department of ENT Surgery, James Cook University Hospital, Middlesbrough, UK
    Otol Neurotol 26:819-20. 2005
  58. doi Endolymphatic sac tumors
    Satoru Shimizu
    J Neurosurg 109:569-70; author reply 570. 2008
  59. ncbi [Characteristic findings in tumor of the endolymphatic sac]
    S Ziyeh
    Sektion Neuroradiologie, Neurozentrum, Universitatsklinikum Freiburg
    Rofo 176:1514-5. 2004
  60. pmc Neurologic manifestations of von Hippel-Lindau disease
    John A Butman
    Diagnostic Radiology Department, The Clinical Center of the National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    JAMA 300:1334-42. 2008
    ..Central nervous system lesions include hemangioblastomas (the most common tumor in VHL) and endolymphatic sac tumors (ELSTs)...
  61. ncbi Lateral semicircular canal and vertigo in patients with large vestibular aqueduct syndrome
    Ieda Maria Ishida
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 27:788-92. 2006
    ....
  62. ncbi [Tumour staged surgery of endolymphatic sac tumors (ELST)]
    J Schipper
    Universitätsklinik für Hals, Nasen und Ohrenheilkunde und Poliklinik, Universitatsklinikum Freiburg
    Laryngorhinootologie 83:493-500. 2004
    b>Endolymphatic sac tumours (ELST) have only been known as own tumour entities since 1984. ELST might occur solitarily and sporadically as well as hereditary connected to von Hippel-Lindau disease (VHL)...
  63. ncbi Endolymphatic sac tumors: a review of the St. Vincent's hospital experience
    Stephen Rodrigues
    Department of Otolaryngology, Head and Neck Surgery, St Vincent s Hospital, Sydney, Australia
    Otol Neurotol 25:599-603. 2004
    To describe the clinical, radiologic and histopathologic features of endolymphatic sac tumors using the St Vincent's Hospital experience with these tumors to highlight important aspects of tumor diagnosis and treatment...
  64. ncbi Paget disease and sensorineural hearing loss associated with spiral ligament degeneration
    Karen Borne Teufert
    Histopathology Department, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 26:387-91; discussion 391. 2005
    ..Previously unreported cystic degeneration of the spiral ligament in cases of Paget disease...
  65. ncbi A new animal model for Ménière's disease
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 128:263-71. 2008
    ..Induction of vestibular dysfunction in the hydropic animal model may entail additional stress such as reduced inner ear blood flow, and sudden acute changes in endolymph volume and/or pressure...
  66. ncbi Cholesterol granuloma surrounding the endolymphatic sac
    Sho Kanzaki
    Department of Otorhinolaryngology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Auris Nasus Larynx 34:95-100. 2007
    We report a unique case of cholesterol granuloma (CG) surrounding the endolymphatic sac (ES). A 49-year-old man presented with the left side of sensorineural hearing loss, tinnitus, and vertigo...
  67. ncbi Diameter of the vestibular aqueduct
    Michael Sargent
    Pediatr Radiol 37:241. 2007
  68. ncbi Endolymphatic sac tumor of temporal bone
    N C Cimsit
    Department of Radiology, Marmara University Hospital, Istanbul, Turkey
    JBR-BTR 89:120-1. 2006
  69. ncbi Can a fixed measure serve as a pertinent diagnostic criterion for large vestibular aqueduct in children?
    Marc Legeais
    Department of Neuroradiology, CHU de Tours, 2 boulevard Tonnele, 37044, Tours Cedex, France
    Pediatr Radiol 36:1037-42. 2006
    ..A vestibular aqueduct midpoint width greater than 1.50 mm is currently considered to be pathognomonic for a large vestibular aqueduct syndrome...
  70. ncbi The large vestibular aqueduct--case report and review of the literature
    Silke Steinbach
    Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Munich, Germany
    Acta Otolaryngol 126:788-95. 2006
    ..We successfully performed a cochlear implant (MED-EL, Combi 40+ flex). Proceeding from this case report, the paper reviews the literature on LVA...
  71. ncbi Endolymphatic sac tumour: a rare cause of recurrent vertigo
    Y K Ong
    Department of Otorhinolaryngology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore
    Singapore Med J 47:627-30. 2006
    b>Endolymphatic sac tumour occurring in a 32-year-old man presenting with Meniere's like symptoms of recurrent vertigo, hearing loss and tinnitus is described...
  72. ncbi Endolymphatic sac papillary tumor (Heffner tumor)
    Michele Bisceglia
    Department of Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, v le Cappuccini, I 71013 San Giovanni Rotondo, Foggia, Italy
    Adv Anat Pathol 13:131-8. 2006
  73. ncbi Endolymphatic sac tumor in a patient with von Hippel-Lindau disease: MR imaging findings
    Ozgur Kilickesmez
    Department of Radiology, Dort D Millet Hospital, Tekirdag, Turkey
    Diagn Interv Radiol 12:14-6. 2006
    ..The mass, studied by MR imaging, was almost completely cystic in appearance. Pathological examination after removal of the mass confirmed a papillary endolymphatic sac tumor.
  74. ncbi ["Endolymphatic" cochleo-vestibular disorders]
    P Tran Ba Huy
    Hopital Lariboisiere, Clinique ORL, 2 rue Ambroise Pare, F 75475 Paris Cedex 10, France
    Rev Laryngol Otol Rhinol (Bord) 126:217-22. 2005
    ..We hope that in the next years new investigation tools will allow to explore in a noninvasive way the endolymphatic contents and dysfunctions of these structures...
  75. ncbi The radiologic diagnosis of endolymphatic sac tumors
    Nirmal P Patel
    Division of Otolaryngology Head and Neck Surgery, University of Utah, Salt Lake City, Utah 84132, USA
    Laryngoscope 116:40-6. 2006
    To identify and classify radiologic criteria for the diagnosis of endolymphatic sac tumors.
  76. ncbi Endolymphatic sac tumor located around semicircular canals
    Tadashi Wada
    Department of Otolaryngology, Niigata University, Graduate School of Medical and Dental Science, Japan
    Auris Nasus Larynx 33:173-7. 2006
    We report a case of endolymphatic sac tumor (ELST). A 48-year-old female had recurrent and slowly progressive hearing loss, accompanied with dizziness like Meniere's disease...
  77. ncbi Cochlear implantation for hearing loss associated with bilateral endolymphatic sac tumors in von Hippel-Lindau disease
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Otol Neurotol 28:927-30. 2007
    Bilateral endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and often underlie significant audiovestibular morbidity, including hearing loss.
  78. ncbi Evaluation and management of endolymphatic sac and duct tumors
    Cliff A Megerian
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Otolaryngol Clin North Am 40:463-78, viii. 2007
    The endolymphatic sac tumor is a slow-growing, locally aggressive neoplasm that originates from the epithelium of the endolymphatic sac and duct...
  79. ncbi Endolymphatic sac tumor demonstrated by intralabyrinthine hemorrhage. Case report
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 107:421-5. 2007
    b>Endolymphatic sac tumors (ELSTs) are locally invasive neoplasms that arise in the posterior petrous bone and are associated with von Hippel-Lindau (VHL) disease...
  80. ncbi Effects of VHL deficiency on endolymphatic duct and sac
    Sven Glasker
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 65:10847-53. 2005
    ..within central nervous system (CNS), kidneys, pancreas, adrenal glands, epididymis, broad ligament, and the endolymphatic sac/petrous bone...
  81. ncbi Distal renal tubular acidosis associated with large vestibular aqueduct and sensorineural hearing loss
    Yukiko Shinjo
    Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Acta Otolaryngol 125:667-70. 2005
    ..We suggest that all children with distal renal tubular acidosis (dRTA) should be subjected to an equilibrium study and audiological evaluation, as well as to a CT or MRI scan...
  82. ncbi Cochlear implantation in a bilateral endolymphatic sac tumor patient. A case report
    Carlos M Boccio
    Hospital Italiano de Buenos Aires, ENT, Buenos Aires, Argentina
    Int J Pediatr Otorhinolaryngol 71:1803-7. 2007
    ..We report the unusual case of bilateral endolymphatic sac tumor in a 14-year-old girl who presented bilateral anacusis and in whom a cochlear implant was performed ..
  83. ncbi Low-grade adenocarcinoma of endolymphatic sac origin
    Saurabh Malhotra
    Department of Pathology, Kasturba Medical College, Manipal, Karnataka, India
    Am J Otolaryngol 27:362-5. 2006
    We present a case of papillary cystic low-grade adenocarcinoma of endolymphatic sac origin. These tumors are very rare and only a few cases have been reported in literature...
  84. ncbi Endolymphatic sac tumours
    D A Luff
    Department of Otolaryngology, Head and Neck Surgery, Manchester Royal Infirmary, UK
    J Laryngol Otol 116:398-401. 2002
    b>Endolymphatic sac tumours (ELST) are rare tumours of the petrous temporal bone. They may arise sporadically or be associated with von Hippel-Lindau disease. Their differential diagnosis is discussed...
  85. ncbi History of Meniere's disease and its clinical presentation
    Fernando Mancini
    Department of Otolaryngology, Ospedale Koelliker, Corso G Ferraris, 251, 10134 Torino, Italy
    Otolaryngol Clin North Am 35:565-80. 2002
    ..It seems reasonable to explain symptoms of Meniere's disease on the basis of mechanical factors (as observed in temporal bone studies) associated with biologic and biochemical factors...
  86. ncbi Etiology, pathophysiology of symptoms, and pathogenesis of Meniere's disease
    Michael M Paparella
    Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA
    Otolaryngol Clin North Am 35:529-45, vi. 2002
    ..Various factors associated with the phenomenon of hydrops include functional or anatomic obstruction of endolymphatic flow, malabsorption of endolymph, genetic anomalies, vasodilation, allergy, viral infection, and autoimmunity...
  87. ncbi Enlarged vestibular aqueduct in two male siblings
    C M Varghese
    Children s Centre, Halliwell, Bolton, UK
    Dev Med Child Neurol 44:706-11. 2002
    ..Perchlorate discharge tests were positive in both infants leading to a diagnosis of Pendred syndrome. A number of conditions associated with EVA are discussed with a view to devising management strategies...
  88. ncbi Endolymphatic sac tumor: unique features of two cases and review of the literature
    M A T Ferreira
    Division of Neurological Surgery, Barrow Neurological Institute, Saint Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    Acta Neurochir (Wien) 144:1047-53. 2002
    b>Endolymphatic sac tumors (EST) are rare intracranial tumors originating from the pars rugosa of the endolymphatic sac...
  89. ncbi [Endolymphatic sac adenocarcinoma: case report]
    Roberto Leal Silveira
    Serviço de Neurocirurgia Professor Guilherme Cabral, Hospital Madre Teresa, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Arq Neuropsiquiatr 60:847-51. 2002
    A case of endolymphatic sac adenocarcinoma is reported and the literature is reviewed. The clinical picture was presented by vertigo and progressive hearing loss caused by a tumor of the endolymphatic sac...
  90. ncbi [Adenocarcinoma of the endolymphatic sac in children. A case report]
    F Facon
    Hopital Nord, Service d ORL et de Chirurgie Cervico faciale, Chemin des Bourrellys, F 13915 Marseille, France
    Rev Laryngol Otol Rhinol (Bord) 123:55-9. 2002
    We report a case of an adenocarcinoma of the endolymphatic sac in a 13 years old child, which was fortuitously discovered at the time of radiological investigation of growth delay...
  91. ncbi Endolymphatic sac tumors in von Hippel-Lindau disease
    Anil K Lalwani
    Department of Otolaryngology, New York University, 550 First Avenue, New York, NY 10016, USA
    Arch Otolaryngol Head Neck Surg 133:857. 2007
  92. ncbi [Papillary tumor of the inner ear: adenoma or carcinoma?]
    S Hattenberger
    Institut fur Pathologie, Städtisches Klinikum, Celler Strasse 38, 38114 Braunschweig
    HNO 50:161-4. 2002
    ..The lesion was surgically removed by radical resection. Histologically, a papillary tumor of the endolymphatic sac was diagnosed...
  93. ncbi [Inner ear and subarachnoid spaces: relations and diseases]
    K Marsot-Dupuch
    Service de Neuroradiologie, , 75, ,
    Ann Otolaryngol Chir Cervicofac 118:171-80. 2001
    ..Therefore, in patients referred for cochleovestibular symptoms, MR and CT study should carefully scrutinise not only the IAM but also the aperture of the cochlear and the vestibular aqueducts and the cerebellopontine meninges...
  94. ncbi Endolymphatic sac tumor: a case report
    S Inanli
    Department of Otorhinolaryngology, Marmara University School of Medicine, Head and Neck Surgery, Istanbul, Turkey
    Auris Nasus Larynx 28:245-8. 2001
    ..The term 'endolymphatic sac tumor' identifies the origin of these rare tumors...
  95. ncbi Autoimmune inner ear disease: diagnostic and therapeutic approaches in a multidisciplinary setting
    Eric L Matteson
    Department of Internal Medicine, Division of Rheumatology Mayo Clinic and Mayo Graduate School of Medicine Rochester, Minnesota 55905, USA
    J Am Acad Audiol 14:225-30. 2003
    ..It is well accepted that the endolymphatic sac is an immunocompetent organ and circulating autoantibodies against inner ear antigens have been reported, as ..
  96. ncbi Endolymphatic sac tumor (low-grade papillary adenocarcinoma) of the temporal bone
    Kenneth O Devaney
    Department of Pathology, Foote Hospital, Jackson, Michigan, USA
    Acta Otolaryngol 123:1022-6. 2003
    The entity which has come to be known as an endolymphatic sac tumor (ELST) has, in the past, been known as adenocarcinoma of endolymphatic sac origin, aggressive papillary tumor of the temporal bone and Heffner's tumor...
  97. ncbi MR imaging, CT, and angiography features of endolymphatic sac tumors: report of two cases
    F Baltacioglu
    Department of Radiology, Faculty of Medicine, Marmara University, Radyoloji Anabilim Dali, Istanbul, Turkey
    Neuroradiology 44:91-6. 2002
    Low-grade adenocarcinoma of endolymphatic sac origin is a rare tumor of the temporal bone. There are some difficulties in its differential diagnosis from other vascular and non-vascular tumors of the temporal bone...
  98. ncbi Massive endolymphatic sac and vestibular aqueduct in Mondini dysplasia
    Andre L L Sampaio
    International Hearing Foundation, Minneapolis, MN, USA
    Arch Otolaryngol Head Neck Surg 130:678-80. 2004
    ..The physician should be prepared to diagnose congenital hearing impairment promptly to avoid complications during the clinical and surgical treatment of patients with Mondini dysplasia...
  99. ncbi Estimation of the endolymphatic sac and vestibular aqueduct using magnetic resonance imaging
    Mari Kobayashi
    Department of Otolaryngology, School of Medicine, Tokyo Medical and Dental University, Japan
    Laryngoscope 113:1015-21. 2003
    To evaluate the diagnostic accuracy of magnetic resonance imaging for assessment of the endolymphatic sac and vestibular aqueduct.
  100. ncbi Endolymphatic sac tumor in von Hippel-Lindau disease
    Robert A Williamson
    Bobby R Alford Department of Otorhinolaryngology, Baylor College of Medicine, Houston, TX 77030, USA
    Otol Neurotol 24:832. 2003
  101. ncbi Perfusion of the inner ear with streptomycin
    J J Shea
    Shea Clinic, Memphis, Tennesse
    Am J Otol 10:150-5. 1989
    ..It is certainly true that endolymphatic hydrops, caused by the failure of absorption of endolymph in the endolymphatic sac, is the principal pathology in the classical, fully developed Meniere's disease...

Research Grants78

  1. Regulation of auditory neuron neurite growth by activity
    Marlan Hansen; Fiscal Year: 2007
    ..The results of these studies will provide critical data on the consequences of electrical activity on SGN neurite growth and cochlear innervation. ..
  2. Modern Studies of the Human Temporal Bone
    Akira Ishiyama; Fiscal Year: 2007
    ..We will collaborate with Dr. Kumar Alagramam in the development of RNA extraction using laser capture microdissection, and with Dr. Allen Ryan in the application of in situ hybridization on formalin-fixed paraffin-embedded sections. ..
  3. INNER EAR IMMUNE RESPONSES
    Elizabeth Keithley; Fiscal Year: 2002
    ..The development of an inner ear immune response involves the endolymphatic sac, an extension of the membraneous labyrinth within the temporal bone projecting into the dura adjacent to the ..
  4. Potassium Homeostasis in the Inner Ear
    Ebenezer N Yamoah; Fiscal Year: 2010
    ..tightly linked to the activity of K+ channels in cells of the medial wall (Reissner's membrane, RM) and endolymphatic sac (ES). We have made substantial progress towards the objectives of the proposal in the last grant cycle...
  5. Recent Advancees in Otitis Media: Research Conference
    David Lim; Fiscal Year: 2003
    ..Additionally, we plan to post the panel reports on HEI's otitis media web page (with permission from the publisher). ..
  6. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2009
    ..abstract_text> ..
  7. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2007
    ..abstract_text> ..
  8. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2010
    ....
  9. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2003
    ....
  10. Ninth Research Conference on Recent Advances in Otitis Media
    David Lim; Fiscal Year: 2007
    ....
  11. Innate Immunity in Otitis Media Pathogenesis
    David Lim; Fiscal Year: 2009
    ....
  12. 5th Intn'l.Symp.:Meniere's Disease/Inner Ear Homeostasis
    David Lim; Fiscal Year: 2005
    ..abstract_text> ..
  13. Molecular biology of deafness in the Meniere's Model
    CLIFF MEGERIAN; Fiscal Year: 2007
    ....
  14. INNER EAR FLUID INTERACTIONS
    ALEC SALT; Fiscal Year: 2007
    ..Treatments will be screened that could potentially influence endolymph volume. The findings from these combined studies are expected to directly impact both the diagnosis and management of Meniere's disease. ..
  15. INNER EAR FLUID INTERACTIONS
    ALEC SALT; Fiscal Year: 2009
    ..Treatments will be screened that could potentially influence endolymph volume. The findings from these combined studies are expected to directly impact both the diagnosis and management of Meniere's disease. ..
  16. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2010
    ..These studies seek to identify the underlying cellular abnormalities that lead to tumor formation and to identify novel therapies that specifically limit schwannoma growth. ..
  17. INNER EAR FLUID INTERACTIONS
    Alec N Salt; Fiscal Year: 2010
    ..This project seeks to develop an understanding of pharmacokinetics in the ear that will, in conjunction with computer models, allow drug treatment protocols to be scientifically based. ..
  18. Vestibular Pathology in Meniere's Disease
    Akira Ishiyama; Fiscal Year: 2007
    ..or with alterations in neuronal number or size? 6) What are the morphometric correlates to abnormalities on traditional vestibular testing: caloric paresis, and decreased gain and time constant on step rotational testing? ..
  19. Deafness Research Foundation Clinical Research Workshop
    GEORGE GATES; Fiscal Year: 2005
    ..Attendees will be physicians and clinicians in communication disorders, such as audiologists and speech/language pathologists. Fellowships will be available for attendees. ..
  20. Presbycusis: Biomedical Risk Factors
    GEORGE GATES; Fiscal Year: 2005
    ..abstract_text> ..
  21. PRESBYCUSIS--BIOMEDICAL RISK FACTORS
    GEORGE GATES; Fiscal Year: 1993
    ..Knowing whether cardiovascular disease or its precursors are co-factors in the pathogenesis of certain types of presbycusis will allow a rational approach to prevention and possible treatment...
  22. INNER EAR FLUID INTERACTIONS
    ALEC SALT; Fiscal Year: 1993
    ..Only by understanding how the entire cochleo-vestibular system responds to pathologic disturbances can rational strategies for the prevention diagnosis, and treatment of Meniere's disease be achieved...
  23. Deafness Research Foundation Clinical Research Workshop
    GEORGE GATES; Fiscal Year: 2004
    ..Attendees will be physicians and clinicians in communication disorders, such as audiologists and speech/language pathologists. Fellowships will be available for attendees. ..
  24. INNER EAR FLUID INTERACTIONS
    ALEC SALT; Fiscal Year: 2004
    ..A second project will examine physiologic changes occurring in the endolymphatic sac during manipulations of endolymph volume in the cochlea...
  25. PRESBYCUSIS--BIOMEDICAL RISK FACTORS
    GEORGE GATES; Fiscal Year: 2001
    ..Identification of families with inherited presbycusis will facilitate future molecular genetic studies to identify genes for inherited defects. ..
  26. Deafness Research Foundation Clinical Research Workshop
    GEORGE GATES; Fiscal Year: 2003
    ..Fellowships will be available for attendees with a demonstrated commitment to clinical research as evidenced by a preliminary research project and letters of support in their applications. ..
  27. Barany Society XXII Regular Meeting, Seattle, WA USA
    GEORGE GATES; Fiscal Year: 2002
    ..e., hair cell regeneration vs. development of a vestibular prosthesis. Younger scientists will have the opportunity to present their own work in either the platform or poster session. ..
  28. INNER EAR FLUID INTERACTIONS
    ALEC SALT; Fiscal Year: 1999
    ..Comparable measures will be made in animals in which the endolymphatic sac has been ablated, to assess the role of this structure in endolymph volume regulation...
  29. ErbB receptor regulation of Vestibular Schwannomas
    JONI DOHERTY; Fiscal Year: 2007
    ..Treatment is limited to surgery or radiation. The proposed project investigates the molecular events that cause vestibular schwannomas with the goal of developing a new medical treatment alternative. ..