Genomes and Genes
Summary: Spiral tube in the bony canal of the cochlea, lying on its outer wall between the scala vestibuli and SCALA TYMPANI.
Publications200 found, 100 shown here
- Myosin II regulates extension, growth and patterning in the mammalian cochlear ductNorio Yamamoto
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Development 136:1977-86. 2009..Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns...
- The role of Pax2 in mouse inner ear developmentQuianna Burton
National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Dev Biol 272:161-75. 2004..Lack of Pax2 affects tissue specification within the cochlear duct, particularly regions between the sensory tissue and the stria vascularis...
- Blockage of reuniting duct in Meniere's diseaseHideo Yamane
Department of Otorhinolaryngology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
Acta Otolaryngol 130:233-9. 2010....
- Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafnessO Minowa
Department of Cell Biology, The Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
Science 285:1408-11. 1999..The findings suggest that these fibrocytes, which are mesenchymal in origin and for which a role in potassium ion homeostasis has been postulated, may play a critical role in auditory function...
- Importance of type IV collagen, laminin, and heparan sulfate proteoglycan in the regulation of labyrinthine fluid in the rat cochlear ductH Satoh
Department of Otolaryngology, Niigata University School of Medicine, Japan
Eur Arch Otorhinolaryngol 255:285-8. 1998..such as type IV collagen, laminin, and heparan sulfate proteoglycan (HSPG), was investigated in the rat cochlear duct. Immunofluorescence demonstrated that type IV collagen, laminin and HSPG were distributed along capillaries in ..
- Ultrastructural localization of megalin in the rat cochlear ductK Mizuta
Department of Otolaryngology, Hamamatsu University School of Medicine, Japan
Hear Res 129:83-91. 1999..In the present study, localization of megalin was examined using a post-embedding immunogold method in the rat cochlear duct. Marginal cells of the stria vascularis were labeled on the apical surface, but not on the basolateral surface...
- Comprehensive Wnt-related gene expression during cochlear duct development in chickenUlrike J Sienknecht
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Comp Neurol 510:378-95. 2008The avian cochlear duct houses both a vestibular and auditory sensory organ (the lagena macula and basilar papilla, respectively), which each have a distinct structure and function...
- Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner earCraig B Stevens
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
Dev Biol 261:149-64. 2003..Retrovirus-mediated misexpression of Wnt3a also gave rise to ectopic vestibular patches in the cochlear duct. In situ hybridization revealed that genes for three Frizzled receptors, c-Fz1, c-Fz7, and c-Fz10, are ..
- Cellular commitment and differentiation in the organ of CortiMatthew W Kelley
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA
Int J Dev Biol 51:571-83. 2007..cochlea, develops from a subset of cells located along the dorsal side (referred to as the floor) of the cochlear duct. Over the course of embryonic development, cells within the developing organ of Corti become committed to ..
- Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicityLiping Nie
Center for Neuroscience, Department of Otolaryngology, University of California, Davis 95616, USA
J Biol Chem 280:15097-102. 2005..The mechanism for the ototoxic effects of DFMO remains uncertain. The cochlear duct is exclusively endowed with endocochlear potential (EP)...
- Comparative analysis of Gata3 and Gata2 expression during chicken inner ear developmentKersti Lilleväli
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Dev Dyn 236:306-13. 2007..We also found indications that the regulatory hierarchy observed in mouse, where Gata3 is upstream of Gata2 and Fgf10, could be conserved in chicken...
- Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleasShun ichi Imamura
Department of Otolaryngology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
J Assoc Res Otolaryngol 4:196-218. 2003..The results have implications for efforts directed toward detecting, preventing, and treating toxic effects of aminoglycosides upon the inner ear...
- Distribution of gentamicin in the guinea pig inner ear after local or systemic applicationShun ichi Imamura
Department of Otolaryngology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
J Assoc Res Otolaryngol 4:176-95. 2003....
- Apical phosphatidylserine externalization in auditory hair cellsXiaorui Shi
Oregon Hearing Research Center NRC04, Department of Otolaryngology, Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
Mol Membr Biol 24:16-27. 2007..These results indicate that PS exposure on the external leaflet, presumably requiring vesicular transport, results from elevation of intracellular cAMP, which can be triggered by Na(+) entry into hair cells...
- Endolymphatic sodium homeostasis by Reissner's membraneJ H Lee
Kansas State University, Department of Anatomy and Physiology, 126 Coles Hall, 1600 Denison Ave, Manhattan, KS 66506 5802, USA
Neuroscience 119:3-8. 2003..These results provide the first direct evidence that Reissner's membrane contributes to normal cochlear function by absorption of Na(+) from endolymph...
- Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigsAkinobu Kakigi
Department of Otolaryngology, Kochi Medical School, Nankoku, Japan
ORL J Otorhinolaryngol Relat Spec 66:291-6. 2004..Thereafter, no prominent rebound phenomenon was noted. Clinically, since isosorbide is orally administered every 8 h, rebound phenomenon need not be considered in the treatment with isosorbide...
- Correlation between hearing loss and scala media area in guinea pigs with long-standing endolymphatic hydropsMorgan E Hott
Departmentof Otolaryngology Head and Neck Surgery, University of Massachusetts Medical School, Worcester, USA
Otol Neurotol 24:64-72. 2003..It was hypothesized that a greater correlation than previously reported might be found by looking at long-standing endolymphatic hydrops and high-frequency range hearing...
- [Quantification of endolymphatic hydrops in experimental animal model]Qin Liang
Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China
Zhonghua Er Bi Yan Hou Ke Za Zhi 39:32-5. 2004..To investigate a method of quantification of the endolymphatic hydrops in experimental animal model...
- Degeneration of the stria vascularis during development in melanocyte-deficient mutant rats (Ws/Ws rats)Satsuki Araki
Department of Otolaryngology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
Eur Arch Otorhinolaryngol 259:309-15. 2002..The above findings lead the authors to believe that intermediate cells play an important role in the development and maintenance of marginal cells and the strial capillary system...
- [Science and life--the history of Marquis Alfonso Corti]Stanisław Betlejewski
Katedra Zdrowia Publicznego Collegium Medicum im L Rydygiera w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu
Otolaryngol Pol 62:344-7. 2008..Unfortunately he was gradually developing arthritis deformans. Corti's last 15 years were further darkened by the inexorable progress of his crippling illness. In 1876, on the second of October, he died at Corvino San Quirico...
- Effect of acute endolymphatic hydrops overload on the endolymphatic sacNana Akagi
Hiroshima University School of Medicine, Hiroshima, Japan
Acta Otolaryngol 128:239-44. 2008..Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role...
- Effects of hyperbaric therapy on function and morphology of Guinea pig cochlea with endolymphatic hydropsFang Lu Chi
Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, PR China
Otol Neurotol 25:553-8. 2004..The objective of this study was to investigate the effect on experimental endolymphatic hydrops in guinea pigs after hyperbaric therapy...
- Spiral ganglion degeneration patterns in endolymphatic hydropsPaul J Bixenstine
Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Laryngoscope 118:1217-23. 2008..The goal of this study is to evaluate the hypothesis that spiral ganglion cell degeneration is the principle pathologic site of ELH-related cochlear injury, correlates with ELH severity, and is most profound in the apical region...
- The effect of BAPTA and 4AP in scala media on transduction and cochlear gainP M Sellick
The Auditory Laboratory, Discipline of Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, WA 6009, Australia
Hear Res 211:7-15. 2006..The effect of 4AP and BAPTA on neural threshold and the receptor current represented by CM may be explained by their action on OHC transduction without the involvement of IHCs...
- Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systemsM Liu
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 14:2839-54. 2000..There are also defects in differentiation and patterning of the cochlear duct and sensory epithelium and loss of the dorsal cochlear nucleus...
- Impact of electrode insertion depth on intracochlear traumaOliver Adunka
Department of Otolaryngology, Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7070, USA
Otolaryngol Head Neck Surg 135:374-82. 2006..To assess the effect of cochlear implant (CI) insertion depth and surgical technique on intracochlear trauma...
- Cellular localization of facilitated glucose transporter 1 (GLUT-1) in the cochlear stria vascularis: its possible contribution to the transcellular glucose pathwayMotonori Ando
Laboratory of Cell Physiology, Department of Science Education, Okayama University, Okayama, Japan
Cell Tissue Res 331:763-9. 2008..The three-dimensional relationship between marginal cells and basal cells might contribute to the transcellular glucose pathway from perilymph to intrastrial space...
- Expression of CLC-K chloride channels in the rat cochleaChunyan Qu
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Suite 309, P O Box 250908, Charleston, SC 29425, USA
Hear Res 213:79-87. 2006..These data support the hypothesis that both isoforms of ClC-K are co-expressed in some cell membranes and account for the preservation of hearing in the presence of a mutation in only one channel isoform...
- [The early postnatal development of the hamster cochlea]W Giebel
, Tubingen, Germany
Laryngorhinootologie 80:725-30. 2001..In the apical turn the epithelial layer of the cochlear duct is undifferentiated, whereas in the basal turn the papilla basilaris (KÃ¶lliker's organ), the lateral wall ..
- CT of the ear in Pendred syndromeMoshe Goldfeld
Departments of Radiology and Internal Medicine, Western Galilee Hospital, Nahariya 22100, Israel
Radiology 235:537-40. 2005..To prospectively determine the structural anomalies of the inner ear by using thin-section computed tomography (CT) in an extended family with Pendred syndrome...
- [Labyrinthectomy with preservation of the cochlear duct and a reconstruction of the lateral wall in the vestibule]Kazimierz Niemczyk
Katedra i Klinika Otolaryngologii AM w Warszawie
Otolaryngol Pol 56:173-9. 2002..In 3 cases of the neuromas removal the residual hearing was preserved. In remained cases of labyrinthectomy hearing was preserved partially...
- Cellular growth and rearrangement during the development of the mammalian organ of CortiErynn McKenzie
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, USA
Dev Dyn 229:802-12. 2004..Recent results suggest that physical changes in the overall size and shape of the cochlear duct, including possible convergence and extension, could play a role in the development of this pattern...
- Age effects and size effects in the ears of gekkonomorph lizards: inner earDaniel D Gehr
ENT Department, Technische Universitat Munchen, Ismaninger Strasse 22, D 81664 München, Germany
Hear Res 200:38-50. 2005..Otoconial mass, as measured by its volume, was correlated with animal length both interspecifically and intraspecifically...
- Dan is required for normal morphogenesis and patterning in the developing chick inner earTakahiro Yamanishi
Division of Pattern Formation, Department of Organogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
Dev Growth Differ 49:13-26. 2007..both a severe reduction in the size of the ed/es and moderate deformities of the semicircular canals and cochlear duct. Depletion of Dan also caused suppression of Nkx5...
- Effect of artificial endolymph injection into the cochlear duct on perilymph potassiumAkinobu Kakigi
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
ORL J Otorhinolaryngol Relat Spec 71:16-8. 2010..To investigate the relationship between endolymphatic hydrops and perilymphatic potassium...
- Single unit recordings in the auditory nerve of congenitally deaf white cats: morphological correlates in the cochlea and cochlear nucleusD K Ryugo
Center for Hearing Sciences, Department Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 397:532-48. 1998..obvious abnormalities in the tectorial membrane, supporting cells, and Reissner's membrane throughout the cochlear duct and had complete inner and outer hair cell loss in the base...
- Anatomy of the middle-turn cochleostomyBrandon Isaacson
Department of Otolaryngology, Head and Neck Surgery, Southwestern Medical Center, Dallas, TX 75390 9035, USA
Laryngoscope 118:2200-4. 2008..This study evaluates the anatomic characteristics of the middle-turn cochleostomy and its suitability for placement of implant electrodes...
- Endocytosis of microperoxidase in the marginal cells of stria vascularisAkinobu Kakigi
Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
Auris Nasus Larynx 34:39-43. 2007..We investigated the basic properties of endocytosis in the marginal cells of stria vascularis (SV) to discuss whether marginal cells have a potential to maintain the endolymph homeostasis...
- Notch signalling pathway mediates hair cell development in mammalian cochleaP J Lanford
Department of Cell Biology, Georgetown University School of Medicine, Washington, DC 20007, USA
Nat Genet 21:289-92. 1999..by an interceding supporting cell, forming an invariant and alternating mosaic that extends the length of the cochlear duct. Previous results suggest that determination of cell fates in the cochlear mosaic occurs via inhibitory ..
- [Experimental endolymphatic hydrops and its related morphological and functional changes in guinea pigs]Y Ye
PUMC Hospital, Beijing
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 12:84-9. 1990..Hydrops in the cochlear duct was evident in the apical and/or near apical turns, especially in earlier stages...
- Mutation of the POU-domain gene Brn4/Pou3f4 affects middle-ear sound conduction in the mouseDaniel S Samadi
Mammalian Neurogenetics Group, Center for Childhood Communication, Division of Pediatric Otolaryngology, The Children s Hospital of Philadelphia, 712 Abramson Research Center, 34th and Civic Blvd, Philadelphia, PA 19104, USA
Hear Res 199:11-21. 2005Mutagenesis of the POU-domain gene Brn4/Pou3f4 causes defects in the cochlear duct, semicircular canal, temporal bone and stapes footplate...
- The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestationM Royster
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Endocrinology 136:3892-900. 1995..receptors, such as the olfactory neuronal epithelium and olfactory bulb, trigeminal and dorsal root ganglia, cochlear duct, brown adipose tissue, submandibular glands, whisker follicles, tooth primordia, and proliferative and ..
- Molecular characterization and expression of maternally expressed gene 3 (Meg3/Gtl2) RNA in the mouse inner earShehnaaz S M Manji
Gene Identification and Expression, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
J Neurosci Res 83:181-90. 2006..to the spiral ganglion, stria vascularis, Reissner's membrane, and greater epithelial ridge (GER) in the cochlear duct. RT-PCR analysis performed on cell lines derived from the organ of Corti, representing neural, supporting, and ..
- Presence and regulation of epithelial sodium channels in the marginal cells of stria vascularisAkinobu Kakigi
Department of Otolaryngology, Kochi Medical School, Kochi, Japan
Acta Otolaryngol 128:233-8. 2008..These results suggest the presence of ENaC in the luminal membrane of marginal cells and that ENaC are an efficient pathway for the uptake of Na(+) from the endolymph...
- Col11a1 and Col11a2 mRNA expression in the developing mouse cochlea: implications for the correlation of hearing loss phenotype with mutant type XI collagen genotypeKarl B Shpargel
Section on Gene Structure and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, USA
Acta Otolaryngol 124:242-8. 2004....
- Ante mortem ruptures of the endolymphatic membranes in children: real finding or artifact?Edgar Bachor
Department of Otorhinolaryngology, Universitat Ulm, Germany
ORL J Otorhinolaryngol Relat Spec 64:390-6. 2002..The endolymphatic membranes of the cochlear duct, saccule, utricle and semicircular ducts were examined for ruptures...
- Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signalingZhengshi Lin
Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
Development 132:2309-18. 2005..phenotypes include absence of the anterior and posterior semicircular canals, and a malformed saccule and cochlear duct. However, formation of the lateral semicircular canal and its ampulla is usually unaffected...
- Postnatal maturation of the dog stria vascularis-- an immunohistochemical studyAngélique G Coppens
Laboratory of Anatomy and Embryology, Veterinary Anatomy, Free University of Brussels, Brussels, Belgium
Anat Rec A Discov Mol Cell Evol Biol 270:82-92. 2003The lateral wall of the dog cochlear duct was investigated by classical staining and immunohistochemistry for NaK/ATPase beta2 isoform, cytokeratins (Cks), vimentin, nestin, and S100A6 during the postnatal cochlear maturation, i.e...
- Chick cochlear efferent neurons are not immunoreactive for calcitonin gene-related peptideR A Code
Department of Zoology, University of Maryland, College Park 20742 4415, USA
Hear Res 97:127-35. 1996The fluorescent retrograde tracer, rhodamine dextran amine, was unilaterally injected into the cochlear duct of anesthetized chicks...
- Resultant Pressure Distribution Pattern along the Basilar Membrane in the Spiral Shaped CochleaYong Zhang
Institute of Physics and Applied Physics, Yonsei University, Seoul, 120 749, Korea
J Biol Phys 33:195-211. 2007..exactly at the apex but at a position determined by the spiral geometry of the cochlea and the width of the cochlear duct. In these modes, the spanwise normal velocities are not zero...
- Depth of electrode insertion and postoperative performance in humans with cochlear implants: a histopathologic studyJoonhan Lee
Department of Otology and Laryngology, Harvard Medical School, Boston, Mass, USA
Audiol Neurootol 15:323-31. 2010..the array's apical tip; (2) inserted length (IL) from the cochleostomy to the apical tip of the array, and (3) cochlear duct length (CDL) from the round window to the helicotrema...
- Altered traveling wave propagation and reduced endocochlear potential associated with cochlear dysplasia in the BETA2/NeuroD1 null mouseAnping Xia
The Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, One Baylor Plaza, NA102, Houston, TX 77030, USA
J Assoc Res Otolaryngol 8:447-63. 2007The BETA2/NeuroD1 null mouse has cochlear dysplasia. Its cochlear duct is shorter than normal, there is a lack of spiral ganglion neurons, and there is hair cell disorganization...
- Endocytosis of MPO in marginal cells is regulated by PKC, protein phosphatase, ERK and PI3-K signaling cascades, but not by PKA and MEK signaling cascadesAkinobu Kakigi
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
ORL J Otorhinolaryngol Relat Spec 72:188-95. 2010..perfused MPO, an endocytosis tracer, with PMA, OA, staurosporin, PAO, PD98059, SB20580 or wortmannin into the cochlear duct. After 30 min endolymphatic perfusion, the tissues were fixed and the distribution of MPO was examined by ..
- Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner earKristen Radde-Gallwitz
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Comp Neurol 477:412-21. 2004..at relatively high levels in the sensory primordium while down-regulated in the other regions of the cochlear duct. As the sensory epithelium starts to differentiate, it is down-regulated in the entire cochlear epithelium...
- The development of the spiral ganglion in the human foetusA Bibas
Institute of Laryngology and Otology, Royal Free and University College London Medical School, England
Folia Morphol (Warsz) 65:140-4. 2006..At 15 weeks the spiral ganglion has increased its distance from the cochlear duct and is surrounded by mesenchyme near the scala tympani...
- Developmental expression of aquaporin 2 in the mouse inner earM Merves
Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Ohio, USA
Laryngoscope 110:1925-30. 2000..The objective of the present study was to define the developmental temporal and spatial expression pattern of aquaporin 2 (Aqp2) in the developing mouse inner ear...
- Tympanal travelling waves in migratory locustsJames F C Windmill
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK
J Exp Biol 208:157-68. 2005..In mammals, frequency analysis relies on the mechanical response of the basilar membrane in the cochlear duct. These vibrations take the form of a slow vibrational wave propagating along the basilar membrane from base to ..
- Malformation of stria vascularis in the developing inner ear of the German waltzing guinea pigZhe Jin
Center for Hearing and Communication Research, Karolinska University Hospital, Solna, Stockholm, Sweden
Cell Tissue Res 328:257-70. 2007..The lumen of the cochlear duct diminished progressively from embryonic day (E) 35 to E45 and was absent at E50 because of the complete ..
- Molecular and functional characterization of gap junctions in the avian inner earRegina Nickel
Centre for Auditory Research, The Ear Institute, University College London, London WC1X 8EE, United Kingdom
J Neurosci 26:6190-9. 2006..In situ hybridization indicated that cCx30 and cCx26 transcripts were both widely expressed in the cochlear duct and utricle in an overlapping pattern, suggesting coexpression of these isoforms similar to that in the ..
- Cubilin and megalin co-localize in the neonatal inner earJacob Tauris
Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus, Denmark
Audiol Neurootol 14:267-78. 2009..cells, to epithelial cells at the spiral prominence and to epithelial cells of Reissner's membrane facing the cochlear duct. In the vestibular apparatus, positive labelling was found in dark cells of the utricle and those flanking the ..
- Inner ear anatomy is a proxy for deducing auditory capability and behaviour in reptiles and birdsStig A Walsh
Department of Palaeontology, The Natural History Museum, London SW7 5BD, UK
Proc Biol Sci 276:1355-60. 2009..and audition-related behaviours in extinct reptiles and birds have previously been based on comparing cochlear duct dimensions with those of living species...
- Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner earLiping Nie
Center for Neuroscience, Department of Otolaryngology, University of California, Davis, California 95616, USA
J Neurosci 25:8671-9. 2005An outcome of the intricate K+ regulation in the cochlear duct is the endocochlear potential (EP), approximately 80 mV, the "battery" that runs hair-cell transduction; however, the detailed molecular mechanisms for the generation of the ..
- Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox geneW Wang
Brookdale Center for Development and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Development 125:621-34. 1998..Both the sensory and secretory epithelium of the cochlear duct appear normal in the Hmx3 null animals. The majority of Hmx3 null females have a reproductive defect...
- Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of CortiIngrid Breuskin
GIGA Neurosciences, University of Liege, Belgium
Dev Biol 335:327-39. 2009..Morphological analyses of Sox10 mutant mice reveal a significant shortening of the cochlear duct likely resulting from the progressive depletion of cochlear progenitors...
- Sonic hedgehog (SHH) promotes the differentiation of mouse cochlear neural progenitors via the Math1-Brn3.1 signaling pathway in vitroXiaohua Hu
Auditory Molecular Biology Laboratory, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
J Neurosci Res 88:927-35. 2010Sonic hedgehog (SHH) is essential for the development of the cochlear duct that harbors the organ of Corti...
- Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesisEvan M Braunstein
Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
BMC Dev Biol 9:31. 2009..To study the function of Tbx1 in the POM, we have conditionally inactivated Tbx1 in the mesoderm while keeping expression in the otic vesicle intact...
- Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formationEvan M Braunstein
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Assoc Res Otolaryngol 9:33-43. 2008..data establish a genetic interaction between Tbx1 and Brn4 relevant to human disease and indicate a function of these genes in signaling from the periotic mesenchyme to the otic vesicle to direct proper coiling of the cochlear duct.
- Molecular mechanisms of sound amplification in the mammalian cochleaJ F Ashmore
Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 97:11759-64. 2000Mammalian hearing depends on the enhanced mechanical properties of the basilar membrane within the cochlear duct. The enhancement arises through the action of outer hair cells that act like force generators within the organ of Corti...
- Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutantMichele Merves
Department of Pediatric Otolaryngology, Center for Hearing and Deafness Research, Cincinnati, OH 45229, USA
J Assoc Res Otolaryngol 4:264-75. 2003..5 in the nonsensory epithelium and later restricted to the lateral wall of the cochlear duct near the spiral prominence...
- Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29E R Wilcox
Laboratory of Molecular Genetics, 5 Research Court, NIDCD NIH, Rockville, MD 20850, USA
Cell 104:165-72. 2001Tight junctions in the cochlear duct are thought to compartmentalize endolymph and provide structural support for the auditory neuroepithelium...
- Localization of bone morphogenetic protein-4 messenger RNA in developing mouse cochleaT Takemura
Department of Otalaryngology, Osaka University Medical School, Japan
Hear Res 95:26-32. 1996..As development proceeded, the hair cells of the cochlear duct were morphologically distinguishable...
- Pre- and postnatal expression of glycoconjugates (3-fucosyl-N-acetyllactosamine and HNK-1 epitopes) in the mouse inner earA Meyer zum Gottesberge
Department of Otorhinolaryngology, Heinrich Heine University of Dusseldorf, Germany
Int J Dev Neurosci 15:645-56. 1997..of CD57 documented the nerve outgrowth and formation of the innervation of the vestibular apparatus and cochlear duct. Correlation between CD15 and CD57 expression patterns revealed differences in the interaction of the ..
- Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9N G Robertson
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Genomics 46:345-54. 1997..mCoch-5B2 was genetically mapped in the mouse to chromosome 12, in a region of homologous synteny with human 14q11.2-q13, which contains the asp1 (audiogenic seizure prone) locus in the mouse...
- TRAF6-dependent NF-kB transcriptional activity during mouse developmentKathleen M Dickson
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Dev Dyn 231:122-7. 2004..These data indicate that NF-kB transcriptional activity is present in a broad range of structures during development and that TRAF6 plays a critical role mediating developmental NF-kB activation in many but not all tissues...
- Practical model description of peripheral neural excitation in cochlear implant recipients: 4. model development at low pulse rates: general model and application to individualsLawrence T Cohen
Department of Otolaryngology, The University of Melbourne, Australia
Hear Res 248:15-30. 2009..The model comprises a population of neural fibers spread along the cochlear duct, with normally distributed thresholds. Each has a finite dynamic range, allowing stochastic behavior...
- Spiral ligament pathology in quiet-aged gerbilsSamuel S Spicer
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Charleston, SC 29425, USA
Hear Res 172:172-85. 2002..The vacuolization and degeneration exclusive to ATPase-rich fibrocytes and the associated intercellular edema are interpreted as secondary responses, possibly as a result of impaired diffusion of K(+) through downstream marginal cells...
- Effects of coiling on the micromechanics of the mammalian cochleaHongxue Cai
Section on Auditory Mechanics, NIH NIDCD, Building 10, Room 5D49, Bethesda, MD 20892, USA
J R Soc Interface 2:341-8. 2005..The WKB perturbation method is used to treat the propagation of travelling waves along the coiled cochlear duct, and the O(1) system of the governing equations is solved in the transverse plane using finite-element ..
- GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochleaXiong Jian Luo
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China
Hum Mol Genet 22:3609-23. 2013..developing inner ear disrupts the morphogenesis of mouse inner ear, resulting in a disorganized and shortened cochlear duct with significant fewer hair cells and supporting cells...
- Light microscopy study of cisplatin-induced ototoxicity in ratsM R de Freitas
Department of Surgery, Medical School, Federal University of Ceara, Fortaleza, Ceara, Brazil
J Laryngol Otol 123:590-7. 2009..This paper describes a simple method of histological assessment of cisplatin-induced ototoxicity in rats, and relates morphological changes to functional changes in hearing detected by distortion product evoked otoacoustic emissions...
- Vestibular development in marsupials and monotremesKen W S Ashwell
Department of Anatomy, School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia
J Anat 224:447-58. 2014..apparatus at a more mature state (fully developed semicircular ducts and a ductus reuniens forming between the cochlear duct and saccule, but no semicircular canals)...
- Partially overlapping expression of Gata2 and Gata3 during inner ear developmentKersti Lilleväli
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Dev Dyn 231:775-81. 2004..Gata2 is predominantly expressed in the dorsal vestibular system, Gata3 was detected mainly in the ventral cochlear duct and ganglion...
- Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochleaRenjie Chai
Department of Otolaryngology Head and Neck Surgery, Stanford University, CA 94305, USA
J Assoc Res Otolaryngol 12:455-69. 2011..In this study, we used a knock-in reporter mouse to examine the spatiotemporal expression of Lgr5 in the cochlear duct during embryonic and postnatal periods. In the embryonic day 15.5 (E15...
- 4-aminopyridine in scala media reversibly alters the cochlear potentials and suppresses electrically evoked oto-acoustic emissionsD L Kirk
Department of Physiology, The University of Western Australia, Nedlands, Australia
Audiol Neurootol 3:21-39. 1998..Reductions in EEOAEs were consistent with the extrinsically applied generating current entering the OHC via the MET channels. Implications for the activation of OHC electromotility in vivo are discussed...
- Biophysics of the cochlea - biomechanics and ion channelopathiesJonathan Ashmore
Department of Physiology, University College London, UK
Br Med Bull 63:59-72. 2002..The transducer channel remains to be identified. The biomechanics of the cochlear duct depends on an energy-dependent feedback from the sensory outer hair cells...
- Dissecting the molecular basis of organ of Corti development: Where are we now?Bernd Fritzsch
Department of Biology, College of Liberal Arts and Sciences, 143 BB, University of Iowa, Iowa City, IA 52242, USA
Hear Res 276:16-26. 2011This review summarizes recent progress in our understanding of the molecular basis of cochlear duct growth, specification of the organ of Corti, and differentiation of the different types of hair cells...
- Ultrastructure and blood supply of the tegmentum vasculosum in the cochlea of the ducklingFred E Hossler
Department of Anatomy and Cell Biology, J H Quillen College of Medicine, Box 70582, East Tennessee State University, Johnson City 37614, USA
Hear Res 164:155-65. 2002..of the duckling consists of a highly folded epithelium which extends over the dorsal and lateral walls of the cochlear duct, separating the scala media from the scala vestibuli...
- MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouseYing Wang
Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
Differentiation 76:1081-92. 2008..In addition, MUC16 protein was detected in other cell types, such as the surface epithelia of the cochlear duct and chief cells of the stomach, suggesting multiple roles for MUC16...
- Sensory cell regeneration and stem cells: what we have already achieved in the management of deafnessPetros V Vlastarakos
ENT Department, Hippokrateion General Hospital of Athens, Athens, Greece
Otol Neurotol 29:758-68. 2008....
- Presbycusic neuritic degeneration within the osseous spiral laminaMargaret A Chen
Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, and Department of Electron Microscopy, House Ear Institute, Los Angeles, California 90057, USA
Otol Neurotol 27:316-22. 2006..To describe a neglected anatomic variant occurring with presbycusis...
- Anatomic study of maximum intensity projection of the membranous labyrinth and the internal auditory meatus - MRI scan in 16 Chinese adultsQing Ling Meng
Department of Anatomy, An Hui Medical University, Hefei, China
Acta Otolaryngol 127:1150-6. 2007..In this study, we establish magnetic resonance imaging (MRI) measurement criteria of the inner ear in Chinese adults...
- Hearing loss in a mouse model of Muenke syndromeSuzanne L Mansour
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
Hum Mol Genet 18:43-50. 2009..with an alteration in the fate of supporting cells (Deiters'-to-pillar cells) along the entire length of the cochlear duct, with the most extreme abnormalities found at the apical or low-frequency end...
- Anatomic evaluation of the membranous labyrinth by imaging: 3D-MRI volume-rendered reconstructionsA Migueis
Coimbra University School of Medicine, Department of Anatomy, Rua Larga, 3004 504 Coimbra, Portugal
Rev Laryngol Otol Rhinol (Bord) 128:37-40. 2007..The authors aimed at verifying the contribution of VR in the study of labyrinthine pathology in view of all the possible anatomic correlation...
- Immunohistochemical localization of G protein betagamma subunits in the lateral wall of the rat cochleaKhalid M Khan
Department of Biological and Biomedical Sciences, Faculty of Health Sciences, The Aga Khan University, Karachi, Pakistan
J Anat 208:205-18. 2006..The identity of Galpha subunits in the stria vascularis and the spiral ligament of the lateral wall of the cochlear duct is well established. However, little is known about the presence of betagamma subunits...
- Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouseAlfredo Calderon
Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
Hear Res 221:44-58. 2006..In the mutant cochlea, the apical turn failed to form due to the developmental growth arrest of the cochlear duct at the level of the first turn at gestational day 13.5...
- COUP-TFI controls Notch regulation of hair cell and support cell differentiationLouisa S Tang
Huffington Center on Aging, Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
Development 133:3683-93. 2006..number of hair cells is not increased over wild type, perhaps because of displaced hair cells and a shortened cochlear duct. This implicates a defect of convergent-extension in the COUP-TFI(-/-) duct...
- All functional aquaporin-4 isoforms are expressed in the rat cochlea and contribute to the formation of orthogonal arrays of particlesB Hirt
Institute of Anatomy, University of Tubingen, Österbergstraβe 3, 72074 Tubingen, Germany
Neuroscience 189:79-92. 2011..freeze-fracture studies revealed OAPs distributed in the lateral and basal membrane domains of the cochlear duct supporting cells, specifically Hensen's cells and outer sulcus cells...
- Examining planar cell polarity in the mammalian cochleaHelen May-Simera
Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Methods Mol Biol 839:157-71. 2012....
- Complementary and layered expression of Ephs and ephrins in developing mouse inner earJames O Pickles
Vision Touch and Hearing Research Centre, University of Queensland, 4072 Queensland, Australia
J Comp Neurol 449:207-16. 2002..of EphA4 and its potential ligand ephrin-A2 were found, with ephrin-A2 in many of the structures lining the cochlear duct and within the cochlear nerve cells, and EphA4 in the deeper structures underlying the cochlear duct and in ..
- Photochemically induced focal cochlear lesions in the guinea pig: I. DAB staining and SEM studyJ Gao
Department of Otolaryngology, Hamamatsu University School of Medicine, Japan
Microsc Res Tech 41:323-33. 1998..The cochlear duct of the guinea pig appears to be segmentally nourished by the capillary system...
- Identifying MicroRNAs Involved in Aging of the Lateral Wall of the Cochlear DuctQian Zhang
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, United States of America
PLoS ONE 9:e112857. 2014..Degeneration of the organ of Corti and atrophy of the lateral wall of the cochlear duct (or scala media) in the inner ear are the two primary causes...
- The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochleaElizabeth Carroll Driver
Laboratory of Cochlear Development, National Institute on Deafness and Other Communications Disorders, NIH, Bethesda, MD 20892, USA
Dev Biol 376:86-98. 2013..Progenitors of HCs and SCs are found in the same post-mitotic region of the cochlear duct during early stages of cochlear development, and both HCs and SCs are absent in mice lacking the transcription ..
- Regulation of hair cell determination by the Wnt/Calcium signaling pathwayAlain Dabdoub; Fiscal Year: 2012..hair cell formation, 2) Wnt4 signals through the Wnt/Calcium/PKC pathway, 3) PKC regulates cell fate in the cochlear duct, and 4) the activity of Atoh1 can be regulated through PKC phosphorylation...
- Morphogenesis of the organ of CortiPing Chen; Fiscal Year: 2013..by applicant): The organ of Corti consists of 4 parallel rows of sensory hair cells along the length of the cochlear duct. On the apical surface of each hair cell, F actin-filled stereociliary bundles form a "V"-shaped structure...
- Potassium Homeostasis in the Inner EarEbenezer N Yamoah; Fiscal Year: 2013..We further predict that K+ regulation in the cochlear duct is tightly linked to the activity of K+ channels in cells of the medial wall (Reissner's membrane, RM) ..
- Sensory cell fate specification in the inner earDouglas J Epstein; Fiscal Year: 2012..from the notochord, signals directly to ventral regions of the otic epithelium to direct the outgrowth of the cochlear duct. Whereas, Wnt1/Wnt3a, secreted from the dorsal hindbrain, signals to the dorsal otocyst to regulate vestibular ..
- DEVELOPMENT STUDIES OF THE INNER EARDonna M Fekete; Fiscal Year: 2013..of Wnt/2-catenin signaling as a switch between auditory and vestibular (macular) sensory organ fates in the cochlear duct;(2) to explore the function of Wnt signaling as a repulsive axon guidance cue in the developing inner ear;and (..
- Genetic Regulation of Cochlear DevelopmentAndrew K Groves; Fiscal Year: 2013..The organ of Corti derives from a prosensory domain of cells running the length of the embryonic cochlear duct, but the nature of the molecular signals that induce this domain are controversial...
- In vivo Organ of Corti Mechanoelectric PhysiologyAlfred L Nuttall; Fiscal Year: 2013..We will create a mouse model that has the expression of a light sensitive ion channel in the OHCs. Local and targeted application of light will modulate the CA and reveal it's spatial extent along the length of the cochlear duct.
- Developmental patterning of the cochleaTakahiro Ohyama; Fiscal Year: 2013..novel mechanisms governing the decision of cell fate between the sensory and non-sensory epithelium of mouse cochlear duct. We have recently shown that (1) high levels of Bone Morphogenetic Protein (BMP) signaling induce the outer ..
- FGF in sensory system developmentOLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010..development of the organ of Corti is a tightly regulated process, in which a small "prosensory" domain of the cochlear duct is sorted into various types of hair cells and support cells...
- Regulation of sensory cell specification in the developing cochleaOLIVIA MARY BERMINGHAM-MCDONOGH; Fiscal Year: 2013..development of the organ of Corti is a tightly regulated process, in which a small "prosensory" domain of the cochlear duct is sorted into various types of hair cells and support cells...
- K+ channel protein complexes in auditory biologyWILLIAM KOBERTZ; Fiscal Year: 2009..that ensure potassium channel protein-protein complexes properly assembly and maintain K+ homeostasis in the cochlear duct. The KCNQ1-KCNE1 K+ channel complex is the exclusive mechanism for endolymphatic K+ secretion into the ..
- AUDITORY ANALYSIS IN ELECTRIC HEARINGDavid Nelson; Fiscal Year: 2009..Cochlear implants encode stimulus frequency by electrode position along the cochlear duct, with the assumption that different electrodes excite unique populations of auditory nerve fibers...
- INNER EAR ADRENOCORTICOSTEROID RECEPTOR SYSTEMKYLE RAREY; Fiscal Year: 1992..applicant's laboratory have demonstrated presence of receptors for adrenal steroids within tissues of both the cochlear duct and vestibular endorgans...
- Molecular pathology of deafness due to mutation in PMP22MARGARET KOVACH; Fiscal Year: 2004..study proposes a comparative evaluation of expression patterns of the murine PMP22 gene and protein in the cochlear duct for both normal mice and mice with a mutant PMP22...
- Tbx1 Functions in Ear DevelopmentAntonio Baldini; Fiscal Year: 2007..Preliminary data underline the requirement of Tbxl for the growth of the otocyst and for the formation of the cochlear duct and semicircular canals...
- FLOW CYTOMETER WITH CELL SORTING CAPABILITYRAM TEWARI; Fiscal Year: 1992..Rybak will develop and characterize epithelial cell lines from stria vascularis of the cochlear duct. Elble will study the lymphocyte phenotype frequency distribution in patients undergoing treatment for ..
- REGULATION OF HAIR CELL DEVELOPMENT & REGENERATIONDOUGLAS COTANCHE; Fiscal Year: 1992Hair cells in the chick cochlear duct exhibit a precise basal-to- apical gradient in the length, width and number of their stereocilia...
- JEM-123O Electron MicroscopeDAVID RYUGO; Fiscal Year: 2003..It will serve to catalyze interdisciplinary discussions among users, provide a valuable teaching tool for our trainees, and enhance the progress of biomedical research on hearing, vision, and voice. ..
- Conditional gene trappingSUZANNE MANSOUR; Fiscal Year: 2004..Successful completion of these aims will set the stage for large-scale gene trap cell line production, which will, in turn, accelerate the production of mouse models of human genetic disease. ..
- Peripherial and Central Mechanisms of Tinnitus GeneratCarol Bauer; Fiscal Year: 2006..Safe and efficacious therapy for this prevalent and often debilitating problem can only occur with improved understanding of the disorder. ..
- DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.Bernd Fritzsch; Fiscal Year: 2010..Such information is crucial to govern the use of neurotrophins for regeneration, plasticity and maintenance of adult innervation. ..
- The function of Foxi3 in craniofacial developmentTakahiro Ohyama; Fiscal Year: 2008..This project has significant potential for the future study of craniofacial and sensory organ development that will shed a light on the genetic mechanisms of craniofacial birth defects. ..
- Investigating the Role of Tbx1 in Ear DevelopmentEvan Braunstein; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..