Genomes and Genes
Summary: Spiral tube in the bony canal of the cochlea, lying on its outer wall between the scala vestibuli and SCALA TYMPANI.
Publications161 found, 100 shown here
- Myosin II regulates extension, growth and patterning in the mammalian cochlear ductNorio Yamamoto
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Development 136:1977-86. 2009..Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns...
- Importance of type IV collagen, laminin, and heparan sulfate proteoglycan in the regulation of labyrinthine fluid in the rat cochlear ductH Satoh
Department of Otolaryngology, Niigata University School of Medicine, Japan
Eur Arch Otorhinolaryngol 255:285-8. 1998..such as type IV collagen, laminin, and heparan sulfate proteoglycan (HSPG), was investigated in the rat cochlear duct. Immunofluorescence demonstrated that type IV collagen, laminin and HSPG were distributed along capillaries in ..
- Comprehensive Wnt-related gene expression during cochlear duct development in chickenUlrike J Sienknecht
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Comp Neurol 510:378-95. 2008The avian cochlear duct houses both a vestibular and auditory sensory organ (the lagena macula and basilar papilla, respectively), which each have a distinct structure and function...
- Ultrastructural localization of megalin in the rat cochlear ductK Mizuta
Department of Otolaryngology, Hamamatsu University School of Medicine, Japan
Hear Res 129:83-91. 1999..In the present study, localization of megalin was examined using a post-embedding immunogold method in the rat cochlear duct. Marginal cells of the stria vascularis were labeled on the apical surface, but not on the basolateral surface...
- Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner earCraig B Stevens
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA
Dev Biol 261:149-64. 2003..Retrovirus-mediated misexpression of Wnt3a also gave rise to ectopic vestibular patches in the cochlear duct. In situ hybridization revealed that genes for three Frizzled receptors, c-Fz1, c-Fz7, and c-Fz10, are ..
- Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigsAkinobu Kakigi
Department of Otolaryngology, Kochi Medical School, Nankoku, Japan
ORL J Otorhinolaryngol Relat Spec 66:291-6. 2004..Thereafter, no prominent rebound phenomenon was noted. Clinically, since isosorbide is orally administered every 8 h, rebound phenomenon need not be considered in the treatment with isosorbide...
- Partially overlapping expression of Gata2 and Gata3 during inner ear developmentKersti Lilleväli
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Dev Dyn 231:775-81. 2004..Gata2 is predominantly expressed in the dorsal vestibular system, Gata3 was detected mainly in the ventral cochlear duct and ganglion...
- Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicityLiping Nie
Center for Neuroscience, Department of Otolaryngology, University of California, Davis 95616, USA
J Biol Chem 280:15097-102. 2005..The mechanism for the ototoxic effects of DFMO remains uncertain. The cochlear duct is exclusively endowed with endocochlear potential (EP)...
- [Science and life--the history of Marquis Alfonso Corti]Stanisław Betlejewski
Katedra Zdrowia Publicznego Collegium Medicum im L Rydygiera w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu
Otolaryngol Pol 62:344-7. 2008..Unfortunately he was gradually developing arthritis deformans. Corti's last 15 years were further darkened by the inexorable progress of his crippling illness. In 1876, on the second of October, he died at Corvino San Quirico...
- Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systemsM Liu
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 14:2839-54. 2000..There are also defects in differentiation and patterning of the cochlear duct and sensory epithelium and loss of the dorsal cochlear nucleus...
- Effects of hyperbaric therapy on function and morphology of Guinea pig cochlea with endolymphatic hydropsFang Lu Chi
Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, PR China
Otol Neurotol 25:553-8. 2004..The objective of this study was to investigate the effect on experimental endolymphatic hydrops in guinea pigs after hyperbaric therapy...
- Spiral ganglion degeneration patterns in endolymphatic hydropsPaul J Bixenstine
Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Laryngoscope 118:1217-23. 2008..The goal of this study is to evaluate the hypothesis that spiral ganglion cell degeneration is the principle pathologic site of ELH-related cochlear injury, correlates with ELH severity, and is most profound in the apical region...
- Distribution of gentamicin in the guinea pig inner ear after local or systemic applicationShun-Ichi Imamura
Department of Otolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
J Assoc Res Otolaryngol 4:176-95. 2003....
- Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleasShun ichi Imamura
Department of Otolaryngology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
J Assoc Res Otolaryngol 4:196-218. 2003..The results have implications for efforts directed toward detecting, preventing, and treating toxic effects of aminoglycosides upon the inner ear...
- Correlation between hearing loss and scala media area in guinea pigs with long-standing endolymphatic hydropsMorgan E Hott
Departmentof Otolaryngology-Head and Neck Surgery, University of Massachusetts Medical School, Worcester, USA
Otol Neurotol 24:64-72. 2003....
- Endolymphatic sodium homeostasis by Reissner's membraneJ H Lee
Kansas State University, Department of Anatomy and Physiology, 126 Coles Hall, 1600 Denison Ave, Manhattan, KS 66506-5802, USA
Neuroscience 119:3-8. 2003..These results provide the first direct evidence that Reissner's membrane contributes to normal cochlear function by absorption of Na(+) from endolymph...
- Cellular commitment and differentiation in the organ of CortiMatthew W Kelley
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA
Int J Dev Biol 51:571-83. 2007..cochlea, develops from a subset of cells located along the dorsal side (referred to as the floor) of the cochlear duct. Over the course of embryonic development, cells within the developing organ of Corti become committed to ..
- Degeneration of the stria vascularis during development in melanocyte-deficient mutant rats (Ws/Ws rats)Satsuki Araki
Department of Otolaryngology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
Eur Arch Otorhinolaryngol 259:309-15. 2002..The above findings lead the authors to believe that intermediate cells play an important role in the development and maintenance of marginal cells and the strial capillary system...
- [Quantification of endolymphatic hydrops in experimental animal model]Qin Liang
Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China
Zhonghua Er Bi Yan Hou Ke Za Zhi 39:32-5. 2004..To investigate a method of quantification of the endolymphatic hydrops in experimental animal model...
- Ultrastructure and blood supply of the tegmentum vasculosum in the cochlea of the ducklingFred E Hossler
Department of Anatomy and Cell Biology, J H Quillen College of Medicine, Box 70582, East Tennessee State University, Johnson City 37614, USA
Hear Res 164:155-65. 2002..of the duckling consists of a highly folded epithelium which extends over the dorsal and lateral walls of the cochlear duct, separating the scala media from the scala vestibuli...
- Effect of acute endolymphatic hydrops overload on the endolymphatic sacNana Akagi
Hiroshima University School of Medicine, Hiroshima, Japan
Acta Otolaryngol 128:239-44. 2008..Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role...
- Apical phosphatidylserine externalization in auditory hair cellsXiaorui Shi
Oregon Hearing Research Center NRC04, Department of Otolaryngology, Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
Mol Membr Biol 24:16-27. 2007..These results indicate that PS exposure on the external leaflet, presumably requiring vesicular transport, results from elevation of intracellular cAMP, which can be triggered by Na(+) entry into hair cells...
- The effect of BAPTA and 4AP in scala media on transduction and cochlear gainP M Sellick
The Auditory Laboratory, Discipline of Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, WA 6009, Australia
Hear Res 211:7-15. 2006..The effect of 4AP and BAPTA on neural threshold and the receptor current represented by CM may be explained by their action on OHC transduction without the involvement of IHCs...
- Impact of electrode insertion depth on intracochlear traumaOliver Adunka
Department of Otolaryngology, Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7070, USA
Otolaryngol Head Neck Surg 135:374-82. 2006..To assess the effect of cochlear implant (CI) insertion depth and surgical technique on intracochlear trauma...
- Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 miceS Hequembourg
Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
J Assoc Res Otolaryngol 2:118-29. 2001..In addition to quantifying the degree and extent of hair cell and neuronal loss, all structures of the cochlear duct were qualitatively evaluated and any degenerative changes were quantified...
- Cellular localization of facilitated glucose transporter 1 (GLUT-1) in the cochlear stria vascularis: its possible contribution to the transcellular glucose pathwayMotonori Ando
Laboratory of Cell Physiology, Department of Science Education, Okayama University, Okayama, Japan
Cell Tissue Res 331:763-9. 2008..The three-dimensional relationship between marginal cells and basal cells might contribute to the transcellular glucose pathway from perilymph to intrastrial space...
- Expression of CLC-K chloride channels in the rat cochleaChunyan Qu
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Suite 309, P O Box 250908, Charleston, SC 29425, USA
Hear Res 213:79-87. 2006..These data support the hypothesis that both isoforms of ClC-K are co-expressed in some cell membranes and account for the preservation of hearing in the presence of a mutation in only one channel isoform...
- Comparative analysis of Gata3 and Gata2 expression during chicken inner ear developmentKersti Lilleväli
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Dev Dyn 236:306-13. 2007..We also found indications that the regulatory hierarchy observed in mouse, where Gata3 is upstream of Gata2 and Fgf10, could be conserved in chicken...
- [The early postnatal development of the hamster cochlea]W Giebel
, Tubingen, Germany
Laryngorhinootologie 80:725-30. 2001..In the apical turn the epithelial layer of the cochlear duct is undifferentiated, whereas in the basal turn the papilla basilaris (KÃ¶lliker's organ), the lateral wall ..
- CT of the ear in Pendred syndromeMoshe Goldfeld
Departments of Radiology and Internal Medicine, Western Galilee Hospital, Nahariya 22100, Israel
Radiology 235:537-40. 2005..To prospectively determine the structural anomalies of the inner ear by using thin-section computed tomography (CT) in an extended family with Pendred syndrome...
- [Labyrinthectomy with preservation of the cochlear duct and a reconstruction of the lateral wall in the vestibule]Kazimierz Niemczyk
Katedra i Klinika Otolaryngologii AM w Warszawie
Otolaryngol Pol 56:173-9. 2002..In 3 cases of the neuromas removal the residual hearing was preserved. In remained cases of labyrinthectomy hearing was preserved partially...
- Cellular growth and rearrangement during the development of the mammalian organ of CortiErynn McKenzie
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, USA
Dev Dyn 229:802-12. 2004..Recent results suggest that physical changes in the overall size and shape of the cochlear duct, including possible convergence and extension, could play a role in the development of this pattern...
- Age effects and size effects in the ears of gekkonomorph lizards: inner earDaniel D Gehr
ENT Department, , Ismaninger Strasse 22, , Germany
Hear Res 200:38-50. 2005..Otoconial mass, as measured by its volume, was correlated with animal length both interspecifically and intraspecifically...
- The role of Pax2 in mouse inner ear developmentQuianna Burton
National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Dev Biol 272:161-75. 2004..Lack of Pax2 affects tissue specification within the cochlear duct, particularly regions between the sensory tissue and the stria vascularis...
- Dan is required for normal morphogenesis and patterning in the developing chick inner earTakahiro Yamanishi
Division of Pattern Formation, Department of Organogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
Dev Growth Differ 49:13-26. 2007..both a severe reduction in the size of the ed/es and moderate deformities of the semicircular canals and cochlear duct. Depletion of Dan also caused suppression of Nkx5...
- Anatomic evaluation of the membranous labyrinth by imaging: 3D-MRI volume-rendered reconstructionsA Migueis
Coimbra University School of Medicine, Department of Anatomy, Rua Larga, 3004 504 Coimbra, Portugal
Rev Laryngol Otol Rhinol (Bord) 128:37-40. 2007..The authors aimed at verifying the contribution of VR in the study of labyrinthine pathology in view of all the possible anatomic correlation...
- Effect of artificial endolymph injection into the cochlear duct on perilymph potassiumAkinobu Kakigi
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
ORL J Otorhinolaryngol Relat Spec 71:16-8. 2010..To investigate the relationship between endolymphatic hydrops and perilymphatic potassium...
- Single unit recordings in the auditory nerve of congenitally deaf white cats: morphological correlates in the cochlea and cochlear nucleusD K Ryugo
Center for Hearing Sciences, Department Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 397:532-48. 1998..obvious abnormalities in the tectorial membrane, supporting cells, and Reissner's membrane throughout the cochlear duct and had complete inner and outer hair cell loss in the base...
- Anatomy of the middle-turn cochleostomyBrandon Isaacson
Department of Otolaryngology, Head and Neck Surgery, Southwestern Medical Center, Dallas, TX 75390 9035, USA
Laryngoscope 118:2200-4. 2008..This study evaluates the anatomic characteristics of the middle-turn cochleostomy and its suitability for placement of implant electrodes...
- Endocytosis of microperoxidase in the marginal cells of stria vascularisAkinobu Kakigi
Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
Auris Nasus Larynx 34:39-43. 2007..We investigated the basic properties of endocytosis in the marginal cells of stria vascularis (SV) to discuss whether marginal cells have a potential to maintain the endolymph homeostasis...
- A detailed 3D model of the guinea pig cochleaBo Liu
Department of Anatomy, Capital Medical University, 10, You An Men Wai, Xi Tou Tiao, Beijing 100069, China
Brain Struct Funct 212:223-30. 2007..modiolus and spiral lamina, (3) cochlea nerve and spiral ganglion, (4) spiral ligament and inferior wall of cochlear duct, (5) Reissner's membrane and (6) tectorial membrane...
- Notch signalling pathway mediates hair cell development in mammalian cochleaP J Lanford
Department of Cell Biology, Georgetown University School of Medicine, Washington, DC 20007, USA
Nat Genet 21:289-92. 1999..by an interceding supporting cell, forming an invariant and alternating mosaic that extends the length of the cochlear duct. Previous results suggest that determination of cell fates in the cochlear mosaic occurs via inhibitory ..
- [Experimental endolymphatic hydrops and its related morphological and functional changes in guinea pigs]Y Ye
PUMC Hospital, Beijing
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 12:84-9. 1990..Hydrops in the cochlear duct was evident in the apical and/or near apical turns, especially in earlier stages...
- Mutation of the POU-domain gene Brn4/Pou3f4 affects middle-ear sound conduction in the mouseDaniel S Samadi
Mammalian Neurogenetics Group, Center for Childhood Communication, Division of Pediatric Otolaryngology, The Children s Hospital of Philadelphia, 712 Abramson Research Center, 34th and Civic Blvd, Philadelphia, PA 19104, USA
Hear Res 199:11-21. 2005Mutagenesis of the POU-domain gene Brn4/Pou3f4 causes defects in the cochlear duct, semicircular canal, temporal bone and stapes footplate...
- The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestationM Royster
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Endocrinology 136:3892-900. 1995..receptors, such as the olfactory neuronal epithelium and olfactory bulb, trigeminal and dorsal root ganglia, cochlear duct, brown adipose tissue, submandibular glands, whisker follicles, tooth primordia, and proliferative and ..
- Molecular characterization and expression of maternally expressed gene 3 (Meg3/Gtl2) RNA in the mouse inner earShehnaaz S M Manji
Gene Identification and Expression, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
J Neurosci Res 83:181-90. 2006..to the spiral ganglion, stria vascularis, Reissner's membrane, and greater epithelial ridge (GER) in the cochlear duct. RT-PCR analysis performed on cell lines derived from the organ of Corti, representing neural, supporting, and ..
- Presence and regulation of epithelial sodium channels in the marginal cells of stria vascularisAkinobu Kakigi
Department of Otolaryngology, Kochi Medical School, Kochi, Japan
Acta Otolaryngol 128:233-8. 2008..These results suggest the presence of ENaC in the luminal membrane of marginal cells and that ENaC are an efficient pathway for the uptake of Na(+) from the endolymph...
- A quantitative analysis of the nerve fibers in the VIIIth nerve of Belgian Waterslager canaries with a hereditary sensorineural hearing lossO Gleich
ENT Department, University of Regensburg, Germany
Hear Res 151:141-148. 2001..In addition, the number of lagenar fibers was determined from cross sections near the apical end of the cochlear duct in order to separate them from the total number of auditory nerve fibers...
- Ante mortem ruptures of the endolymphatic membranes in children: real finding or artifact?Edgar Bachor
Department of Otorhinolaryngology, Universitat Ulm, Germany
ORL J Otorhinolaryngol Relat Spec 64:390-6. 2002..The endolymphatic membranes of the cochlear duct, saccule, utricle and semicircular ducts were examined for ruptures...
- Col11a1 and Col11a2 mRNA expression in the developing mouse cochlea: implications for the correlation of hearing loss phenotype with mutant type XI collagen genotypeKarl B Shpargel
Section on Gene Structure and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, USA
Acta Otolaryngol 124:242-8. 2004....
- Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4Anand N Mhatre
Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
J Neurosci Res 75:25-31. 2004..This vascular tissue borders the cochlear duct and is a critical regulator of potassium concentration in the endolymph...
- Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signalingZhengshi Lin
Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
Development 132:2309-18. 2005..phenotypes include absence of the anterior and posterior semicircular canals, and a malformed saccule and cochlear duct. However, formation of the lateral semicircular canal and its ampulla is usually unaffected...
- Chick cochlear efferent neurons are not immunoreactive for calcitonin gene-related peptideR A Code
Department of Zoology, University of Maryland, College Park 20742 4415, USA
Hear Res 97:127-35. 1996The fluorescent retrograde tracer, rhodamine dextran amine, was unilaterally injected into the cochlear duct of anesthetized chicks...
- Postnatal maturation of the dog stria vascularis-- an immunohistochemical studyAngélique G Coppens
Laboratory of Anatomy and Embryology, Veterinary Anatomy, Free University of Brussels, Brussels, Belgium
Anat Rec A Discov Mol Cell Evol Biol 270:82-92. 2003The lateral wall of the dog cochlear duct was investigated by classical staining and immunohistochemistry for NaK/ATPase beta2 isoform, cytokeratins (Cks), vimentin, nestin, and S100A6 during the postnatal cochlear maturation, i.e...
- Resultant Pressure Distribution Pattern along the Basilar Membrane in the Spiral Shaped CochleaYong Zhang
Institute of Physics and Applied Physics, Yonsei University, Seoul, 120 749, Korea
J Biol Phys 33:195-211. 2007..exactly at the apex but at a position determined by the spiral geometry of the cochlea and the width of the cochlear duct. In these modes, the spanwise normal velocities are not zero...
- Shaping the mammalian auditory sensory organ by the planar cell polarity pathwayMichael Kelly
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Int J Dev Biol 51:535-47. 2007..of precisely patterned rows of sensory hair cells and supporting cells along the length of the snail-shaped cochlear duct. On the apical surface of each hair cell, several rows of actin-containing protrusions, known as stereocilia, ..
- Depth of electrode insertion and postoperative performance in humans with cochlear implants: a histopathologic studyJoonhan Lee
Department of Otology and Laryngology, Harvard Medical School, Boston, Mass, USA
Audiol Neurootol 15:323-31. 2010..the array's apical tip; (2) inserted length (IL) from the cochleostomy to the apical tip of the array, and (3) cochlear duct length (CDL) from the round window to the helicotrema...
- Unique expression pattern of the FGF receptor 3 gene during mouse organogenesisK Peters
Department of Medicine, University of California, San Francisco 94143
Dev Biol 155:423-30. 1993..FGFR3 was also expressed at high levels in differentiating hair cells of the cochlear duct, but was not detected in other sensory epithelia...
- Transport of 5-hydroxydopamine and horseradish peroxidase through the perilymph-endolymph barrierM Sakagami
Department of Otolaryngology, Osaka University Medical School, Japan
Ann Otol Rhinol Laryngol 100:859-65. 1991..Reaction product of 5-OHDA was observed along the endolymphatic surface of the cochlear duct in both 10-minute and 30-minute perfusions, while that of HRP was observed only in the 30-minute perfusion...
- Altered traveling wave propagation and reduced endocochlear potential associated with cochlear dysplasia in the BETA2/NeuroD1 null mouseAnping Xia
The Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, One Baylor Plaza, NA102, Houston, TX 77030, USA
J Assoc Res Otolaryngol 8:447-63. 2007The BETA2/NeuroD1 null mouse has cochlear dysplasia. Its cochlear duct is shorter than normal, there is a lack of spiral ganglion neurons, and there is hair cell disorganization...
- Immunohistochemical localization of G protein betagamma subunits in the lateral wall of the rat cochleaKhalid M Khan
Department of Biological and Biomedical Sciences, Faculty of Health Sciences, The Aga Khan University, Karachi, Pakistan
J Anat 208:205-18. 2006..The identity of Galpha subunits in the stria vascularis and the spiral ligament of the lateral wall of the cochlear duct is well established. However, little is known about the presence of betagamma subunits...
- The development of the spiral ganglion in the human foetusA Bibas
Institute of Laryngology and Otology, Royal Free and University College London Medical School, England
Folia Morphol (Warsz) 65:140-4. 2006..At 15 weeks the spiral ganglion has increased its distance from the cochlear duct and is surrounded by mesenchyme near the scala tympani...
- Developmental expression of aquaporin 2 in the mouse inner earM Merves
Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Ohio, USA
Laryngoscope 110:1925-30. 2000..The objective of the present study was to define the developmental temporal and spatial expression pattern of aquaporin 2 (Aqp2) in the developing mouse inner ear...
- Endocytosis of MPO in marginal cells is regulated by PKC, protein phosphatase, ERK and PI3-K signaling cascades, but not by PKA and MEK signaling cascadesAkinobu Kakigi
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
ORL J Otorhinolaryngol Relat Spec 72:188-95. 2010..perfused MPO, an endocytosis tracer, with PMA, OA, staurosporin, PAO, PD98059, SB20580 or wortmannin into the cochlear duct. After 30 min endolymphatic perfusion, the tissues were fixed and the distribution of MPO was examined by ..
- Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner earKristen Radde-Gallwitz
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Comp Neurol 477:412-21. 2004..at relatively high levels in the sensory primordium while down-regulated in the other regions of the cochlear duct. As the sensory epithelium starts to differentiate, it is down-regulated in the entire cochlear epithelium...
- Photochemically induced focal cochlear lesions in the guinea pig: I. DAB staining and SEM studyJ Gao
Department of Otolaryngology, Hamamatsu University School of Medicine, Japan
Microsc Res Tech 41:323-33. 1998..The cochlear duct of the guinea pig appears to be segmentally nourished by the capillary system...
- Early identification of inner pillar cells during rat cochlear developmentNicolas Thelen
Cellular Biology Unit, Center for Cellular and Molecular Neuroscience, University of Liege, C H U Sart Tilman, B36, 4000, Liege, Belgium
Cell Tissue Res 337:1-14. 2009..cell zone that is located in the junctional region between two edges of the dorsal epithelium of the cochlear duct. We also reveal that the first cells to develop in this zone are the inner pillar cells, a particular type of ..
- COUP-TFI controls Notch regulation of hair cell and support cell differentiationLouisa S Tang
Huffington Center on Aging, Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
Development 133:3683-93. 2006..number of hair cells is not increased over wild type, perhaps because of displaced hair cells and a shortened cochlear duct. This implicates a defect of convergent-extension in the COUP-TFI(-/-) duct...
- Tympanal travelling waves in migratory locustsJames F C Windmill
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK
J Exp Biol 208:157-68. 2005..In mammals, frequency analysis relies on the mechanical response of the basilar membrane in the cochlear duct. These vibrations take the form of a slow vibrational wave propagating along the basilar membrane from base to ..
- Malformation of stria vascularis in the developing inner ear of the German waltzing guinea pigZhe Jin
Center for Hearing and Communication Research, Karolinska University Hospital, Solna, Stockholm, Sweden
Cell Tissue Res 328:257-70. 2007..The lumen of the cochlear duct diminished progressively from embryonic day (E) 35 to E45 and was absent at E50 because of the complete ..
- Molecular and functional characterization of gap junctions in the avian inner earRegina Nickel
Centre for Auditory Research, The Ear Institute, University College London, London WC1X 8EE, United Kingdom
J Neurosci 26:6190-9. 2006..In situ hybridization indicated that cCx30 and cCx26 transcripts were both widely expressed in the cochlear duct and utricle in an overlapping pattern, suggesting coexpression of these isoforms similar to that in the ..
- Cubilin and megalin co-localize in the neonatal inner earJacob Tauris
Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus, Denmark
Audiol Neurootol 14:267-78. 2009..cells, to epithelial cells at the spiral prominence and to epithelial cells of Reissner's membrane facing the cochlear duct. In the vestibular apparatus, positive labelling was found in dark cells of the utricle and those flanking the ..
- Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner earLiping Nie
Center for Neuroscience, Department of Otolaryngology, University of California, Davis, California 95616, USA
J Neurosci 25:8671-9. 2005An outcome of the intricate K+ regulation in the cochlear duct is the endocochlear potential (EP), approximately 80 mV, the "battery" that runs hair-cell transduction; however, the detailed molecular mechanisms for the ..
- Inner ear anatomy is a proxy for deducing auditory capability and behaviour in reptiles and birdsStig A Walsh
Department of Palaeontology, The Natural History Museum, London SW7 5BD, UK
Proc Biol Sci 276:1355-60. 2009..and audition-related behaviours in extinct reptiles and birds have previously been based on comparing cochlear duct dimensions with those of living species...
- Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox geneW Wang
Brookdale Center for Development and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Development 125:621-34. 1998..Both the sensory and secretory epithelium of the cochlear duct appear normal in the Hmx3 null animals. The majority of Hmx3 null females have a reproductive defect...
- Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouseAlfredo Calderon
Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
Hear Res 221:44-58. 2006..In the mutant cochlea, the apical turn failed to form due to the developmental growth arrest of the cochlear duct at the level of the first turn at gestational day 13.5...
- Sonic hedgehog (SHH) promotes the differentiation of mouse cochlear neural progenitors via the Math1-Brn3.1 signaling pathway in vitroXiaohua Hu
Auditory Molecular Biology Laboratory, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
J Neurosci Res 88:927-35. 2010Sonic hedgehog (SHH) is essential for the development of the cochlear duct that harbors the organ of Corti...
- Appearance of glucocorticoid receptors in the inner ear of the mouse during developmentS Erichsen
Department of Otorhinolaryngology, Karolinska Hospital, Stockholm, Sweden
Acta Otolaryngol 116:721-5. 1996..A faint staining of the crista ampullaris, the utricle and the cochlear duct was seen at E19; and staining became clearly visible at P1...
- Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesisEvan M Braunstein
Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
BMC Dev Biol 9:31. 2009..To study the function of Tbx1 in the POM, we have conditionally inactivated Tbx1 in the mesoderm while keeping expression in the otic vesicle intact...
- Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of CortiIngrid Breuskin
GIGA Neurosciences, University of Liege, Belgium
Dev Biol 335:327-39. 2009..Morphological analyses of Sox10 mutant mice reveal a significant shortening of the cochlear duct likely resulting from the progressive depletion of cochlear progenitors...
- Anatomic study of maximum intensity projection of the membranous labyrinth and the internal auditory meatus - MRI scan in 16 Chinese adultsQing Ling Meng
Department of Anatomy, An Hui Medical University, Hefei, China
Acta Otolaryngol 127:1150-6. 2007..In this study, we establish magnetic resonance imaging (MRI) measurement criteria of the inner ear in Chinese adults...
- Three-dimensional analysis of inner ear development in human embryosMegumi Yasuda
Department of Anatomy, Kinki University School of Medicine, Osaka, Japan
Anat Sci Int 82:156-63. 2007..The cochlear duct already begins to extend at stage 16...
- Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner earAnand N Mhatre
Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
J Neurosci Res 76:296-305. 2004..5. Myh9 expression was found to persist within the epithelia surrounding the cochlear duct at E13.5 and E16.5. The sensory cells of the developing cochlea were positive for Myh9 expression at E16.5...
- MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouseYing Wang
Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
Differentiation 76:1081-92. 2008..In addition, MUC16 protein was detected in other cell types, such as the surface epithelia of the cochlear duct and chief cells of the stomach, suggesting multiple roles for MUC16...
- Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formationEvan M Braunstein
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Assoc Res Otolaryngol 9:33-43. 2008..data establish a genetic interaction between Tbx1 and Brn4 relevant to human disease and indicate a function of these genes in signaling from the periotic mesenchyme to the otic vesicle to direct proper coiling of the cochlear duct.
- Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutantMichele Merves
Department of Pediatric Otolaryngology, Center for Hearing and Deafness Research, Cincinnati, OH 45229, USA
J Assoc Res Otolaryngol 4:264-75. 2003..5 in the nonsensory epithelium and later restricted to the lateral wall of the cochlear duct near the spiral prominence...
- Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29E R Wilcox
Laboratory of Molecular Genetics, 5 Research Court, NIDCD NIH, Rockville, MD 20850, USA
Cell 104:165-72. 2001Tight junctions in the cochlear duct are thought to compartmentalize endolymph and provide structural support for the auditory neuroepithelium...
- Molecular mechanisms of sound amplification in the mammalian cochleaJ F Ashmore
Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 97:11759-64. 2000Mammalian hearing depends on the enhanced mechanical properties of the basilar membrane within the cochlear duct. The enhancement arises through the action of outer hair cells that act like force generators within the organ of Corti...
- Localization of bone morphogenetic protein-4 messenger RNA in developing mouse cochleaT Takemura
Department of Otalaryngology, Osaka University Medical School, Japan
Hear Res 95:26-32. 1996..As development proceeded, the hair cells of the cochlear duct were morphologically distinguishable...
- Pre- and postnatal expression of glycoconjugates (3-fucosyl-N-acetyllactosamine and HNK-1 epitopes) in the mouse inner earA Meyer zum Gottesberge
Department of Otorhinolaryngology, Heinrich Heine University of Dusseldorf, Germany
Int J Dev Neurosci 15:645-56. 1997..of CD57 documented the nerve outgrowth and formation of the innervation of the vestibular apparatus and cochlear duct. Correlation between CD15 and CD57 expression patterns revealed differences in the interaction of the ..
- [Pendred's syndrome. Current features]J L Wemeau
Clinique Endocrinologique Marc Linquette, USN A, Hopital Claude Huriez
Presse Med 30:1689-94. 2001..protein involved in anion (l-, Cl-) transportation, notably in the apical pole of the thyreocyte and the cochlear duct, where the endolympha is produced...
- Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9N G Robertson
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Genomics 46:345-54. 1997..mCoch-5B2 was genetically mapped in the mouse to chromosome 12, in a region of homologous synteny with human 14q11.2-q13, which contains the asp1 (audiogenic seizure prone) locus in the mouse...
- TRAF6-dependent NF-kB transcriptional activity during mouse developmentKathleen M Dickson
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Dev Dyn 231:122-7. 2004..These data indicate that NF-kB transcriptional activity is present in a broad range of structures during development and that TRAF6 plays a critical role mediating developmental NF-kB activation in many but not all tissues...
- Practical model description of peripheral neural excitation in cochlear implant recipients: 4. model development at low pulse rates: general model and application to individualsLawrence T Cohen
Department of Otolaryngology, The University of Melbourne, Australia
Hear Res 248:15-30. 2009..The model comprises a population of neural fibers spread along the cochlear duct, with normally distributed thresholds. Each has a finite dynamic range, allowing stochastic behavior...
- Complementary and layered expression of Ephs and ephrins in developing mouse inner earJames O Pickles
Vision Touch and Hearing Research Centre, University of Queensland, 4072 Queensland, Australia
J Comp Neurol 449:207-16. 2002..of EphA4 and its potential ligand ephrin-A2 were found, with ephrin-A2 in many of the structures lining the cochlear duct and within the cochlear nerve cells, and EphA4 in the deeper structures underlying the cochlear duct and in ..
- Presbycusic neuritic degeneration within the osseous spiral laminaMargaret A Chen
Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, and Department of Electron Microscopy, House Ear Institute, Los Angeles, California 90057, USA
Otol Neurotol 27:316-22. 2006..These cases can be identified by a gradual down-sloping audiogram in contrast to sensory (hair cell) presbycusis, which is characterized by a precipitous high tone loss...
- Spiral ligament pathology in quiet-aged gerbilsSamuel S Spicer
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Charleston, SC 29425, USA
Hear Res 172:172-85. 2002..The vacuolization and degeneration exclusive to ATPase-rich fibrocytes and the associated intercellular edema are interpreted as secondary responses, possibly as a result of impaired diffusion of K(+) through downstream marginal cells...
- Expression of osmotic stress protein 94 in murine endolymphatic hydrops modelChang Hee Kim
Department of Physiology, Seoul National University, College of Medicine, Seoul, Korea
Acta Otolaryngol 132:S118-23. 2012..The up-regulation of osmotic stress protein 94 (OSP94) in the murine endolymphatic hydrops (EH) models suggests that OSP94 might be involved in cellular adaptation in response to ionic and osmotic stress in the murine inner ear...
- Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner earBeatriz Lorente-Cánovas
Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
Dis Model Mech 6:434-42. 2013..of endocochlear potential, suggesting a functional defect of the stria vascularis on the lateral wall of the cochlear duct. However, the main K(+) channels involved in the generation of endocochlear potential, Kcnj10 and Kcnq1, are ..
- Redundant functions of Rac GTPases in inner ear morphogenesisCynthia M Grimsley-Myers
Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
Dev Biol 362:172-86. 2012..mutants, accompanied by a loss of epithelial cohesion and formation of ectopic sensory patches underneath the cochlear duct. The compartmentalized expression of otic patterning genes within the Rac1(CKO); Rac3(-/-) mutant otocyst was ..
- Making connections in the inner ear: Recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cellsThomas M Coate
Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA Electronic address
Semin Cell Dev Biol 24:460-9. 2013..the molecular and cellular mechanisms underlying their genesis, how they are precisely arranged along the cochlear duct, and the guidance mechanisms that promote the innervation of their hair cell targets are only now being ..
- Regulation of hair cell determination by the Wnt/Calcium signaling pathwayAlain Dabdoub; Fiscal Year: 2010..hair cell formation, 2) Wnt4 signals through the Wnt/Calcium/PKC pathway, 3) PKC regulates cell fate in the cochlear duct, and 4) the activity of Atoh1 can be regulated through PKC phosphorylation...
- Sensory cell fate specification in the inner earDouglas J Epstein; Fiscal Year: 2010..from the notochord, signals directly to ventral regions of the otic epithelium to direct the outgrowth of the cochlear duct. Whereas, Wnt1/Wnt3a, secreted from the dorsal hindbrain, signals to the dorsal otocyst to regulate vestibular ..
- Potassium Homeostasis in the Inner EarEbenezer N Yamoah; Fiscal Year: 2010..We further predict that K+ regulation in the cochlear duct is tightly linked to the activity of K+ channels in cells of the medial wall (Reissner's membrane, RM) ..
- Genetic Regulation of Cochlear DevelopmentAndrew K Groves; Fiscal Year: 2010..The organ of Corti derives from a prosensory domain of cells running the length of the embryonic cochlear duct, but the nature of the molecular signals that induce this domain are controversial...
- Regulating dorsoventral polarity within the inner earDouglas Epstein; Fiscal Year: 2007..In the absence of Shh, ventral otic derivatives including the cochlear duct and cochleovestibular ganglia fail to develop...
- Morphogenesis of the organ of CortiPing Chen; Fiscal Year: 2010The organ of Corti consists of 4 parallel rows of sensory hair cells along the length of the cochlear duct. On the apical surface of each hair cell, F actin-filled stereociliary bundles form a "V"-shaped structure...
- AUDITORY ANALYSIS IN ELECTRIC HEARINGDavid Nelson; Fiscal Year: 2009..Cochlear implants encode stimulus frequency by electrode position along the cochlear duct, with the assumption that different electrodes excite unique populations of auditory nerve fibers...
- Molecular pathology of deafness due to mutation in PMP22MARGARET KOVACH; Fiscal Year: 2004..study proposes a comparative evaluation of expression patterns of the murine PMP22 gene and protein in the cochlear duct for both normal mice and mice with a mutant PMP22...
- FGF in sensory system developmentOLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010..development of the organ of Corti is a tightly regulated process, in which a small "prosensory" domain of the cochlear duct is sorted into various types of hair cells and support cells...
- Tbx1 Functions in Ear DevelopmentAntonio Baldini; Fiscal Year: 2007..Preliminary data underline the requirement of Tbxl for the growth of the otocyst and for the formation of the cochlear duct and semicircular canals...
- K+ channel protein complexes in auditory biologyWILLIAM KOBERTZ; Fiscal Year: 2009..that ensure potassium channel protein-protein complexes properly assembly and maintain K+ homeostasis in the cochlear duct. The KCNQ1-KCNE1 K+ channel complex is the exclusive mechanism for endolymphatic K+ secretion into the ..
- DEVELOPMENT STUDIES OF THE INNER EARDonna M Fekete; Fiscal Year: 2010..of Wnt/2-catenin signaling as a switch between auditory and vestibular (macular) sensory organ fates in the cochlear duct;(2) to explore the function of Wnt signaling as a repulsive axon guidance cue in the developing inner ear;and (..
- DEVELOPMENT STUDIES OF THE INNER EARDONNA FEKETE; Fiscal Year: 2009..of Wnt/2-catenin signaling as a switch between auditory and vestibular (macular) sensory organ fates in the cochlear duct; (2) to explore the function of Wnt signaling as a repulsive axon guidance cue in the developing inner ear; ..
- K+ channel protein complexes in auditory biologyWILLIAM KOBERTZ; Fiscal Year: 2009..that ensure potassium channel protein-protein complexes properly assembly and maintain K+ homeostasis in the cochlear duct. The KCNQ1-KCNE1 K+ channel complex is the exclusive mechanism for endolymphatic K+ secretion into the ..
- Regulation of sensory cell specification in the developing cochleaOLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010..development of the organ of Corti is a tightly regulated process, in which a small "prosensory" domain of the cochlear duct is sorted into various types of hair cells and support cells...
- Cadherins in the Developing Zebrafish Inner EarJAMES MARRS; Fiscal Year: 2006..However, no cochlea or cochlear duct is found in the fish ear...
- DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.Bernd Fritzsch; Fiscal Year: 2009..Verifying the function of those newly discovered genes in mouse development will greatly enhance our ability to move the already funded R01 project toward translational research. ..
- INNER EAR ION TRANSPORT MECHANISMSBRADLEY SCHULTE; Fiscal Year: 1999....
- INNER EAR ION TRANSPORT MECHANISMSBRADLEY SCHULTE; Fiscal Year: 2005....
- HISTOCHEMICAL STUDIES OF THE COCHLEABRADLEY SCHULTE; Fiscal Year: 1993..This comprehensive and systematic study of the developing cochlea will contribute significantly to our understanding of the molecular and cellular events leading to the establishment of normal auditory function...
- INNER EAR ION TRANSPORT MECHANISMSBRADLEY SCHULTE; Fiscal Year: 2007..Such knowledge will be essential in the design of therapeutic strategies for the treatment of inner ear disorders associated with injury or destruction of specialized populations of inner ear fibrocytes. ..