ear

Summary

Summary: The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.

Top Publications

  1. pmc Mutations in the pre-replication complex cause Meier-Gorlin syndrome
    Louise S Bicknell
    Medical Research Council MRC Human Genetics Unit HGU, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Nat Genet 43:356-9. 2011
  2. ncbi The effect of stimulus intensity on the right ear advantage in dichotic listening
    Kenneth Hugdahl
    Department of Biological and Medical Psychology Cognitive NeuroScience Group, University of Bergen, Norway
    Neurosci Lett 431:90-4. 2008
  3. ncbi Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant
    C Haddon
    Vertebrate Development Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 125:4637-44. 1998
  4. pmc The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation
    Craig N Jenne
    Calvin, Phoebe and Joan Snyder Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 6:e25109. 2011
  5. pmc Intravital immunofluorescence for visualizing the microcirculatory and immune microenvironments in the mouse ear dermis
    Witold W Kilarski
    Institute of Bioengineering and Swiss Institute of Experimental, Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS ONE 8:e57135. 2013
  6. doi Intravital multiphoton imaging of immune responses in the mouse ear skin
    Jackson Liangyao Li
    Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore
    Nat Protoc 7:221-34. 2012
  7. ncbi Netrin 1 is required for semicircular canal formation in the mouse inner ear
    M Salminen
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 127:13-22. 2000
  8. ncbi FGF signaling is required for determination of otic neuroblasts in the chick embryo
    Berta Alsina
    Biologia del Desenvolupament, Departament de Ciències Experimentals i de la Salut DCEXS, Universitat Pompeu Fabra, 08003, Barcelona, Spain
    Dev Biol 267:119-34. 2004
  9. ncbi Stages of normal development in the medaka Oryzias latipes
    Takashi Iwamatsu
    Department of Biology, Aichi University of Education, 16 Terayamashita, Igaya cho, Kariya City, Aichi 448 0001, Japan
    Mech Dev 121:605-18. 2004
  10. ncbi Newborn hearing screening--a silent revolution
    Cynthia C Morton
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:2151-64. 2006

Detail Information

Publications333 found, 100 shown here

  1. pmc Mutations in the pre-replication complex cause Meier-Gorlin syndrome
    Louise S Bicknell
    Medical Research Council MRC Human Genetics Unit HGU, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Nat Genet 43:356-9. 2011
    Meier-Gorlin syndrome (ear, patella and short-stature syndrome) is an autosomal recessive primordial dwarfism syndrome characterized by absent or hypoplastic patellae and markedly small ears¹⁻³...
  2. ncbi The effect of stimulus intensity on the right ear advantage in dichotic listening
    Kenneth Hugdahl
    Department of Biological and Medical Psychology Cognitive NeuroScience Group, University of Bergen, Norway
    Neurosci Lett 431:90-4. 2008
    ..was to further investigate the bottom-up modulation, by examining the effect of differences in the right or left ear stimulus intensity on the ear advantage...
  3. ncbi Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant
    C Haddon
    Vertebrate Development Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 125:4637-44. 1998
    Mechanosensory hair cells in the sensory patches of the vertebrate ear are interspersed among supporting cells, forming a fine-grained pattern of alternating cell types...
  4. pmc The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation
    Craig N Jenne
    Calvin, Phoebe and Joan Snyder Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 6:e25109. 2011
    ..Using these techniques, we describe for the first time, platelet recruitment to, and behaviour within numerous tissues of the mouse, both under control conditions and following LPS induced inflammation...
  5. pmc Intravital immunofluorescence for visualizing the microcirculatory and immune microenvironments in the mouse ear dermis
    Witold W Kilarski
    Institute of Bioengineering and Swiss Institute of Experimental, Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS ONE 8:e57135. 2013
    ..Using the exposed dorsal ear of the anesthetized mouse and a fluorescence stereomicroscope, such events can be imaged in the context of specific ..
  6. doi Intravital multiphoton imaging of immune responses in the mouse ear skin
    Jackson Liangyao Li
    Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore
    Nat Protoc 7:221-34. 2012
    ..Here we provide a step-by-step protocol describing experimental procedures for intravital MP imaging of the mouse ear skin, which can be easily adapted to address many specific skin-related biological questions...
  7. ncbi Netrin 1 is required for semicircular canal formation in the mouse inner ear
    M Salminen
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 127:13-22. 2000
    The morphogenetic development of the mammalian inner ear is a complex multistep process, the molecular and cellular details of which are only beginning to be unraveled...
  8. ncbi FGF signaling is required for determination of otic neuroblasts in the chick embryo
    Berta Alsina
    Biologia del Desenvolupament, Departament de Ciències Experimentals i de la Salut DCEXS, Universitat Pompeu Fabra, 08003, Barcelona, Spain
    Dev Biol 267:119-34. 2004
    ..We suggest that FGF signaling in the otic epithelium is required for neuronal precursors to withdraw from cell division and irreversibly commit to neuronal fate...
  9. ncbi Stages of normal development in the medaka Oryzias latipes
    Takashi Iwamatsu
    Department of Biology, Aichi University of Education, 16 Terayamashita, Igaya cho, Kariya City, Aichi 448 0001, Japan
    Mech Dev 121:605-18. 2004
    ..After hatching, development of the larvae (fry) and young can be divided into six stages based on such diagnostic features as the fins, scales and secondary sexual characteristics...
  10. ncbi Newborn hearing screening--a silent revolution
    Cynthia C Morton
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:2151-64. 2006
  11. doi Matching sender and receiver: poikilothermy and frequency tuning in a tree cricket
    Natasha Mhatre
    School of Biological Sciences, Woodland Road, University of Bristol, Bristol BS8 1UG, UK
    J Exp Biol 214:2569-78. 2011
    ....
  12. ncbi Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning
    Robert M Nissen
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 130:2543-54. 2003
    ..We propose that correct placement of survival/proliferation cues is essential for shaping the pharyngeal cartilages and that evolutionary links between jaw and ear formation can be traced to Fgf-Foxi1-Pax8 pathways.
  13. pmc An in vivo study of turbidity suppression by optical phase conjugation (TSOPC) on rabbit ear
    Meng Cui
    California Institute of Technology, Pasadena, CA 91125, USA
    Opt Express 18:25-30. 2010
    We present a holography-based in vivo optical phase conjugation experiment performed on a living rabbit ear. The motion of live tissues caused the phase conjugate signal to decay with a consistent decay time of less than two seconds...
  14. pmc Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear
    Benjamin Kopecky
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    Dev Dyn 240:1373-90. 2011
    b>Ear development requires interactions of transcription factors for proliferation and differentiation. The proto-oncogene N-Myc is a member of the Myc family that regulates proliferation...
  15. pmc Nasal, oral and ear swabs for canine visceral leishmaniasis diagnosis: new practical approaches for detection of Leishmania infantum DNA
    Sidney de Almeida Ferreira
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, Brasil
    PLoS Negl Trop Dis 7:e2150. 2013
    The aim of this study was to evaluate the potential use of nasal, oral, and ear swabs for molecular diagnosis of canine visceral leishmaniasis (CVL) in an endemic urban area in Brazil.
  16. pmc Dual effect of Lutzomyia longipalpis saliva on Leishmania braziliensis infection is mediated by distinct saliva-induced cellular recruitment into BALB/c mice ear
    Vanessa Carregaro
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, Ribeirao Preto, Sao Paulo, Brazil
    BMC Microbiol 13:102. 2013
    ..In this study, we investigated the initial inflammatory leucocyte composition induced by one or three inocula of salivary gland extract (SGE) from Lutzomyia longipalpis in the presence or absence of Leishmania braziliensis...
  17. pmc Fine mapping of a QTL for ear size on porcine chromosome 5 and identification of high mobility group AT-hook 2 (HMGA2) as a positional candidate gene
    Pinghua Li
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, People s Republic of China
    Genet Sel Evol 44:6. 2012
    b>Ear size and shape are distinct conformation characteristics of pig breeds...
  18. pmc Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear
    Hanna Regus-Leidig
    Department of Biology, Animal Physiology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 8:e70373. 2013
    ..Piccolino, present in retinal photoreceptor cells, bipolar cells, as well as in inner hair cells of the inner ear. By RT-PCR analysis and the generation of a Piccolino-specific antibody we show that non-splicing of intron 5/6 ..
  19. ncbi Human ear recognition in 3D
    Hui Chen
    University of California at Riverside, Riverside, CA 92521, USA
    IEEE Trans Pattern Anal Mach Intell 29:718-37. 2007
    Human ear is a new class of relatively stable biometrics that has drawn researchers' attention recently. In this paper, we propose a complete human recognition system using 3D ear biometrics...
  20. ncbi Genetic control of the rate of wound healing in mice
    X Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, Loma Linda, CA 92357, USA
    Heredity 86:668-74. 2001
    ..Information gained from this investigation provides insight into further study of molecular mechanisms underlying the rate of wound healing in mammals...
  21. pmc Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a newly identified cause of congenital ear malformation
    Lely A Quina
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Dis Model Mech 5:812-22. 2012
    ..at the HMX1 locus as the causative mutation in the oculo-auricular syndrome (OAS) in humans, characterized by ear and eye malformations...
  22. ncbi The red ear syndrome: an auriculo-autonomic cephalgia
    Randolph W Evans
    Headache 44:835-6. 2004
  23. ncbi Evaluation of a new combined transcutaneous measurement of PCO2/pulse oximetry oxygen saturation ear sensor in newborn patients
    Vera Bernet-Buettiker
    Department of Neonatology, University Children s Hospital, Zurich, Switzerland
    Pediatrics 115:e64-8. 2005
    ..The monitor combines pulse oximetry and Ptcco(2) measurement in a single ear sensor, which works at 42 degrees C to enhance blood flow in capillaries below the sensor.
  24. ncbi The role of the ear, nose and throat specialist in diagnosing headaches
    G Felisati
    Clinic of Otorhinolaryngology, ENT Department, San Paolo Hospital, University of Milan, Via di Rudini 8, I 20080, Milan, Italy
    Neurol Sci 26:s83-6. 2005
    The revised International Headache Society classification (2004) represents a very good reference also for ear, nose and throat (ENT) specialists and can be largely shared...
  25. ncbi Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring
    Zol B Kryger
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Am Coll Surg 205:78-88. 2007
    ..TGF-beta) in these processes has been well recognized, and this study sought to define the temporal expression of the key members in this pathway in a well-established, clinically relevant, rabbit ear model of hypertrophic scarring.
  26. doi Parasitological diagnosis of canine visceral leishmaniasis: is intact skin a good target?
    M F Madeira
    Laboratório de Vigilância em Leishmanioses, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, 21045 900 Rio de Janeiro, Brazil
    Res Vet Sci 87:260-2. 2009
    ..Skin obtained from the ear and scapular region was simultaneously analyzed in 247 animals and lesion samples and ear skin were analyzed in 147 ..
  27. pmc Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis
    Sonja A de Munnik
    Department of Human Genetics 836, Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 20:598-606. 2012
    ..No other clear genotype-phenotype association was observed. Growth hormone and estrogen treatment may be of some benefit, respectively, to growth retardation and breast hypoplasia, though further studies in this patient group are needed...
  28. pmc Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping
    Amaury Vaysse
    Institut de Génétique et Développement de Rennes, CNRS UMR6061, Universite de Rennes 1, Rennes, France
    PLoS Genet 7:e1002316. 2011
    ..We chose one highly differentiated region, associated with body size and ear morphology, and characterized it using high-throughput sequencing to provide a list of variants that may directly ..
  29. doi Cutaneous ear lobe Pco₂ at 37°C to evaluate microperfusion in patients with septic shock
    Fabrice Vallee
    Département d Anesthésie Réanimation SMUR, Hopital Lariboisiere, 75010, Paris, France
    Chest 138:1062-70. 2010
    ..This study investigates whether a cutaneous sensor attached to an ear lobe and regulated to 37°C could be used to measure cutaneous Pco₂ (Pcco₂) and evaluate microperfusion in ..
  30. pmc Pitch discrimination interference between binaural and monaural or diotic pitches
    Hedwig E Gockel
    MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    J Acoust Soc Am 126:281-90. 2009
    ..In a third experiment, similar amounts of PDI were observed for CHP targets and for loudness-matched diotic complex-tone targets. Thus, a conventional complex tone and CHP appear to be processed in common at the stage where PDI occurs...
  31. ncbi Anti-inflammatory activities of methanol extracts from various seaweed species
    Mohammed N A Khan
    Faculty of Food Science and Biotechnology, and Institute of Fisheries Sciences, Pukyong National University, Namku, Busan 608 737, Korea
    J Environ Biol 29:465-9. 2008
    ..of Korea were screened for anti-inflammatory activity Methanol extracts of the seaweeds were tested against mouse ear edema and erythema induced by phorbol myristate acetate...
  32. ncbi Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects
    Henry Pau
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Laryngoscope 115:116-24. 2005
    ..Furthermore, the authors investigated where the mutation responsible for these defects was located in the mouse genome...
  33. pmc Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome
    Daniel F Schorderet
    Institut de Recherche en Ophtalmologie, 1950 Sion, Switzerland
    Am J Hum Genet 82:1178-84. 2008
    Several dysmorphic syndromes affect the development of both the eye and the ear, but only a few are restricted to the eye and the external ear...
  34. ncbi The deafness gene dfna5 is crucial for ugdh expression and HA production in the developing ear in zebrafish
    Elisabeth Busch-Nentwich
    Max Planck Institut fur Entwicklungsbiologie, Spemannstr 35, 72076 Tubingen, Germany
    Development 131:943-51. 2004
    ..In dfna5 morphants, expression of ugdh is absent in the developing ear and pharyngeal arches, and HA levels are strongly reduced in the outgrowing protrusions of the developing ..
  35. ncbi Linear processing of spatial cues in primary auditory cortex
    J W Schnupp
    University Laboratory of Physiology, University of Oxford, UK
    Nature 414:200-4. 2001
    ..as well as changes in the sound spectrum caused by the direction-dependent filtering of sound by the outer ear. Behavioural deficits observed when primary auditory cortex (A1) is damaged have led to the widespread view that A1 ..
  36. ncbi Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6
    O Chisaka
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Nature 355:516-20. 1992
    ..The set of defects associated with the disruption of Hox-1.6 is distinct from and nonoverlapping with that of the closely linked Hox-1.5 gene. But both mutations cause loss, rather than homeotic transformation, of tissues and structures...
  37. ncbi Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development
    Marlene J Rau
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 296:83-93. 2006
    ..Mediator is a coactivator complex transducing the interaction of DNA-binding transcription factors with RNA polymerase II, and our results reveal a critical function of the Trap230 subunit as a coactivator for Sox9...
  38. ncbi Effects of interaural decorrelation on neural and behavioral detection of spatial cues
    K Saberi
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 21:789-98. 1998
    ..time differences (ITDs) for sound localization critically depends on the similarity between the left and right ear signals (interaural correlation)...
  39. ncbi Mosaic gene expression in nuclear transfer-derived embryos and the production of cloned transgenic pigs from ear-derived fibroblasts
    Kwang Wook Park
    Department of Animal Sciences, University of Missouri Columbia, 920 East Campus Drive, Columbia, MO 65211, USA
    Biol Reprod 66:1001-5. 2002
    ..In addition, transgene expression in a genetically manipulated embryo may not be an accurate indicator of expression in the resulting offspring...
  40. pmc Molecular evolution of the vertebrate mechanosensory cell and ear
    Bernd Fritzsch
    Creighton University, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Biol 51:663-78. 2007
    ..structures in vertebrate fossils, comparatively less attention has been spent on the evolution of the inner ear and the central auditory system...
  41. ncbi Structure, development, and evolution of insect auditory systems
    D D Yager
    Department of Psychology, University of Maryland, College Park, Maryland 20742, USA
    Microsc Res Tech 47:380-400. 1999
    ..This suggests that the many appearances of hearing could arise from changes in a small number of developmental modules. The nature of those developmental changes that lead to a functional insect ear is not yet known.
  42. doi Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome
    Louise S Bicknell
    Medical Research Council MRC Human Genetics Unit HGU, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Nat Genet 43:350-5. 2011
    ..These findings establish a novel mechanism for the pathogenesis of microcephalic dwarfism and show a surprising but important developmental impact of impaired origin licensing...
  43. ncbi Identification of cartilage progenitor cells in the adult ear perichondrium: utilization for cartilage reconstruction
    Takeshi Togo
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Lab Invest 86:445-57. 2006
    ..We show here the presence of cartilage progenitor cells in the ear perichondrium of adult rabbits by 5-bromo-2'-deoxyuridine labeling, clonogenicity, and differentiation analyses...
  44. ncbi Keeping up with bats: dynamic auditory tuning in a moth
    James Frederick Charles Windmill
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    Curr Biol 16:2418-23. 2006
    ..Yet, moth hearing is not simple; the ear's nonlinear dynamic response shifts its mechanical sensitivity up to high frequencies...
  45. doi Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome
    Duane L Guernsey
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Nat Genet 43:360-4. 2011
    ..This is the first report, to our knowledge, of a germline mutation in any gene of the origin recognition complex in a vertebrate organism...
  46. ncbi A uniquely specialized ear in a very early tetrapod
    J A Clack
    University Museum of Zoology, Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Nature 425:65-9. 2003
    ..In particular, its braincase and ear region defied interpretation, such that conventional anatomical terms seemed inapplicable...
  47. doi Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies: a proof of concept trial
    Hermann Stefan
    Department of Neurology Epilepsy Center, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 53:e115-8. 2012
    ..The noninvasive t-VNS stimulation is a safe and well-tolerated method for relatively long periods, and might be an alternative treatment option for patients with epilepsy...
  48. ncbi Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection
    T Baldwin
    The Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    Parasite Immunol 29:501-13. 2007
    ..in the mouse model that mimics more closely the situation in humans, that is, strictly intradermal infection in the ear pinna with small numbers of metacyclic promastigotes...
  49. pmc Genetic loci that regulate healing and regeneration in LG/J and SM/J mice
    Elizabeth P Blankenhorn
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA gt
    Mamm Genome 20:720-33. 2009
    MRL mice display unusual healing properties. When MRL ear pinnae are hole punched, the holes close completely without scarring, with regrowth of cartilage and reappearance of both hair follicles and sebaceous glands...
  50. doi Evaluation of the in vivo and ex vivo optical properties in a mouse ear model
    E Salomatina
    Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA
    Phys Med Biol 53:2797-807. 2008
    ..Scattering of the ex vivo tissues decreased gradually with time in the entire spectral range due to the continuing loss of blood and partial cell damage. Anisotropy factors did not change considerably...
  51. ncbi Blast injury of the ear: clinical update from the global war on terror
    Kara M Cave
    Army Research Laboratory, Human Research and Engineering Directorate, Aberdeen Proving Ground, MD 21005, USA
    Mil Med 172:726-30. 2007
    ..32% reported a history of tympanic membrane perforation, 49% experienced tinnitus, 26% reported otalgia (ear pain), and 15% reported dizziness...
  52. doi Segmentation and surface reconstruction of the detailed ear structures, identified in sectioned images
    Hae Gwon Jang
    Multimedia and Computer Architecture Lab, Graduate School of Information and Communication, Ajou University, Worldcup ro 206, Suwon, Republic of Korea
    Anat Rec (Hoboken) 294:559-64. 2011
    The structure of the ear, which intervenes between gross anatomy and histology in size, can be best understood by means of three-dimensional (3D) surface models on a computer...
  53. pmc Pitch comparisons between electrical stimulation of a cochlear implant and acoustic stimuli presented to a normal-hearing contralateral ear
    Robert P Carlyon
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Rd, Cambridge, CB2 7EF, England
    J Assoc Res Otolaryngol 11:625-40. 2010
    Four cochlear implant users, having normal hearing in the unimplanted ear, compared the pitches of electrical and acoustic stimuli presented to the two ears...
  54. ncbi Histopathological and parasitological investigations of ear healthy skin of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi
    Maria Marta Figueiredo
    Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Histol Histopathol 25:877-87. 2010
    ..A study of 108 dogs with parasite Leishmania chagasi detected by immuno-histochemistry in healthy ear skin was obtained from two distinct geographical areas: 55 from a metropolitan area of the municipality (Santa ..
  55. pmc Aqueous and methanolic extracts of Caulerpa mexicana suppress cell migration and ear edema induced by inflammatory agents
    Mariana Angelica Oliveira Bitencourt
    Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, University Campus, Lagoa Nova, 59078 900, Natal, RN, Brazil
    Mar Drugs 9:1332-45. 2011
    ..The treatment of mice with C. mexicana extracts also decreased the xylene-induced ear edema, exerting strong inhibitory leukocyte migration elicited by zymosan into the air pouch...
  56. ncbi The developing lamprey ear closely resembles the zebrafish otic vesicle: otx1 expression can account for all major patterning differences
    Katherine L Hammond
    Department of Biomedical Science, Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
    Development 133:1347-57. 2006
    The inner ear of adult agnathan vertebrates is relatively symmetric about the anteroposterior axis, with only two semicircular canals and a single sensory macula...
  57. doi Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies
    Alexander W Wyatt
    Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hum Mutat 31:781-7. 2010
    ..We determined that BMP7 is expressed in the developing eye, brain, and ear in human embryos in a manner consistent with the phenotype seen in our mutation cases...
  58. ncbi Development of the vertebrate ear: insights from knockouts and mutants
    D M Fekete
    Dept of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Trends Neurosci 22:263-9. 1999
    The three divisions of the ear (outer, middle and inner) each have an important role in hearing, while the inner ear is also crucial for the sense of balance...
  59. ncbi Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 468:125-34. 2004
    ..Our study was undertaken to investigate the appearance and developmental expression of espin in chicken inner ear sensory epithelia...
  60. pmc Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals
    E Verpy
    Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique Unite de Recherche Associee 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 96:529-34. 1999
    During the course of a study aimed at identifying inner ear-specific transcripts, a 1,906-bp murine cDNA predicted to encode a secreted 469-aa protein with two domains of homology with the secreted phospholipases A2 was isolated...
  61. ncbi Ear packing after ear surgery: is it really necessary?
    J Borgstein
    Department of Paediatric Otolaryngology, Sophia Children s Hospital, Rotterdam, The Netherlands
    J Laryngol Otol 122:253-4. 2008
    We question the need for packing of the ear canal after ear surgery. For several years, it had not been the first author's standard practice to use post-operative ear packing...
  62. ncbi Otologic surgery following ear trauma
    J Matthew Conoyer
    Otology Group of Vanderbilt, Department of Otolaryngology Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA
    Otolaryngol Head Neck Surg 137:757-61. 2007
    ..To investigate common presentations and expected outcomes in patients with traumatically induced otologic dysfunction...
  63. ncbi The visible ear surgery simulator
    Peter Trier
    Alexandra Institute, University of Aarhus, Denmark
    Stud Health Technol Inform 132:523-5. 2008
    This paper presents a real-time computer simulation of surgical procedures in the ear, in which a surgeon drills into the temporal bone to gain access to the middle or inner ear...
  64. pmc Measurement of cochlear power gain in the sensitive gerbil ear
    Tianying Ren
    Department of Otolaryngology and Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Commun 2:216. 2011
    The extraordinary sensitivity of the mammalian ear is commonly attributed to the cochlear amplifier, a cellular process thought to locally boost responses of the cochlear partition to soft sounds...
  65. doi Development of an indirect immunofluorescence assay for diagnosis of bovine viral diarrhoea virus on ear notch tissue samples in cattle infected persistently
    Tomislav Bedekovic
    Croatian Veterinary Institute, Savska cesta, 143, 10000 Zagreb, Croatia
    J Virol Methods 178:59-62. 2011
    ..Animal sera, whole blood, organ and ear notch tissue samples can be used for BVDV diagnosis...
  66. pmc A new acoustic portal into the odontocete ear and vibrational analysis of the tympanoperiotic complex
    Ted W Cranford
    Department of Biology, San Diego State University, San Diego, California, USA
    PLoS ONE 5:e11927. 2010
    ..Here we identify a new acoustic portal into the ear complex, the tympanoperiotic complex (TPC) and a plausible mechanism by which sound is transduced into the bony ..
  67. pmc Simultaneous measurement of multiple ear proteins with multiplex ELISA assays
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code NRC04, Portland, OR 97239 3098, USA
    Hear Res 275:1-7. 2011
    ..To determine the applicability of this technology for ear research, we used 3 different multiplex ELISA-based immunoassay arrays from 4 different companies to measure ..
  68. doi Engineering ear constructs with a composite scaffold to maintain dimensions
    Libin Zhou
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Tissue Eng Part A 17:1573-81. 2011
    ..However, distortion and shrinkage of ear-shaped constructs during scaffold degradation and neocartilage maturation in vivo have hindered the field...
  69. doi A genome scan for quantitative trait loci affecting three ear traits in a White Duroc x Chinese Erhualian resource population
    J Ma
    Key Laboratory for Animal Biotechnology of Jiangxi Province, Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
    Anim Genet 40:463-7. 2009
    ..To identify quantitative trait loci (QTL) for ear weight and area as well as erectness, a genome-wide scan with 194 microsatellites was performed in a White Duroc x ..
  70. doi Implant double tissue expanders superposingly in mastoid region for total ear reconstruction without skin grafts
    Gan Lin Zhang
    Department of Plastic and Cosmetic Surgery, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, China
    Int J Pediatr Otorhinolaryngol 76:1515-9. 2012
    To present our clinical experience in using two skin soft-tissue expanders implanted superposingly in the mastoid region and Medpor ear framework for congenital microtia reconstruction.
  71. ncbi Biomechanical and neurophysiological studies on audition in eared and earless harlequin frogs (Atelopus)
    E D Lindquist
    Department of Zoology, Ohio State University, Columbus 43210, USA
    J Comp Physiol A 183:265-71. 1998
    ..the auditory midbrain sensitivities to sound were measured in Atelopus species with or without a tympanic middle ear ("eared" and "earless", respectively)...
  72. doi Nanomedicine strategies for drug delivery to the ear
    Christian Oliver Pritz
    Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Anichstraße 35, Austria
    Nanomedicine (Lond) 8:1155-72. 2013
    The highly compartmentalized anatomy of the ear aggravates drug delivery, which is used to combat hearing-related diseases. Novel nanosized drug vehicles are thought to overcome the limitations of classic approaches...
  73. ncbi Directional hearing by mechanical coupling in the parasitoid fly Ormia ochracea
    D Robert
    Section of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853 2702, USA
    J Comp Physiol A 179:29-44. 1996
    ..An intuitive description of the mechanism is proposed using a simple mechanical model in which the ears are coupled through a flexible lever...
  74. doi Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice
    Yan Fang Xian
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, PR China
    J Ethnopharmacol 137:1425-30. 2011
    ....
  75. pmc A downloadable three-dimensional virtual model of the visible ear
    Haobing Wang
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    ORL J Otorhinolaryngol Relat Spec 69:63-7. 2007
    ..To develop a three-dimensional (3-D) virtual model of a human temporal bone and surrounding structures...
  76. pmc Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: targeting new genes in regeneration
    Muhammad Farooq Rai
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110
    G3 (Bethesda) 3:1881-91. 2013
    ..healer) and small (SM/J, nonhealer) intercross, we have previously shown a positive genetic correlation between ear wound healing, knee cartilage regeneration, and protection from osteoarthritis...
  77. doi A comprehensive model of human ear for analysis of implantable hearing devices
    Xiangming Zhang
    Biomedical Engineering Laboratory, Aerospace and Mechanical Engineering and Bioengineering Center, University of Oklahoma, Norman, OK 73019, USA
    IEEE Trans Biomed Eng 58:3024-7. 2011
    A finite element (FE) model of the human ear including the ear canal, middle ear, and spiral cochlea was constructed from histological sections of human temporal bone...
  78. ncbi Primary and secondary red ear syndrome: implications for treatment
    Steven D Bender
    Cephalalgia 27:1286-7; author reply 1287. 2007
  79. ncbi Foreign bodies in the ear, nose, and throat
    Steven W Heim
    University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am Fam Physician 76:1185-9. 2007
    Foreign bodies in the ear, nose, and throat are occasionally seen in family medicine, usually in children. The most common foreign bodies are food, plastic toys, and small household items...
  80. ncbi Transforming growth factor-beta and its effect on reepithelialization of partial-thickness ear wounds in transgenic mice
    Eric B Tredget
    Department of Surgery, Division of Plastic Surgery, Wound Healing Research Group, University of Alberta, Edmonton, Alberta, Canada
    Wound Repair Regen 13:61-7. 2005
    ..Superficial partial-thickness ear wounds involving only the epidermis were made to determine the effect of TGF-beta on reepithelialization...
  81. doi Ear reconstruction with porous polyethylene implants
    Alexander Berghaus
    Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Adv Otorhinolaryngol 68:53-64. 2010
    This article describes a surgical technique using porous polyethylene as the framework material for ear reconstruction...
  82. pmc Stimulus change detection in phasic auditory units in the frog midbrain: frequency and ear specific adaptation
    Abhilash Ponnath
    Neuroscience Center, Department of Otorhinolaryngology, Louisiana State University Health Sciences Center, 2020 Gravier St, New Orleans, LA 70112, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:295-313. 2013
    ..single phasic auditory units in the frog midbrain to determine if adaptation was specific to stimulus frequency and ear of input...
  83. pmc Genome-wide association mapping and identification of candidate genes for the rumpless and ear-tufted traits of the Araucana chicken
    Rooksana E Noorai
    Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America
    PLoS ONE 7:e40974. 2012
    ..Inheritance studies have shown that the rumpless (Rp) and ear-tufted (Et) loci each act in an autosomal dominant fashion, segregate independently, and are associated with an ..
  84. doi Effect of Rhizoma Polygonati on 12-O-tetradecanoylphorbol-acetate-induced ear edema in mice
    Yan Fang Xian
    School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    J Ethnopharmacol 142:851-6. 2012
    ..Rhizoma Polygonati is originated from the dried rhizomes of Polygonatum sibircum Red. It has long been used in traditional Chinese medicine for the treatment of inflammatory disorders...
  85. doi Porcine ear necrosis syndrome: a preliminary investigation of putative infectious agents in piglets and mycotoxins in feed
    C Weissenbacher-Lang
    Clinic for Swine, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria
    Vet J 194:392-7. 2012
    The aim of this study was to identify the causative factors of porcine ear necrosis syndrome (PENS) in 72 pigs, 5.5-10 weeks in age housed on nine farms...
  86. ncbi Plasticity of epidermal adult stem cells derived from adult goat ear skin
    Xueyi Yang
    Shaanxi Branch of National Stem Cell Engineering Center, Northwest A and F University, Yangling, Shaanxi Province, China
    Mol Reprod Dev 74:386-96. 2007
    ..Due to their high degree of inherent plasticity, and to their easy accessibility for collection from the skin, EpiASC are excellent candidate sources for diverse cell therapies...
  87. ncbi Effects of prostaglandin antagonist phloretin derivatives on mouse ear edema induced with different skin irritants
    G Blazso
    Department of Pharmacodynamics, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Prostaglandins 50:161-8. 1995
    Edema was induced in one ear of male mice of the CFLP strain with solutions of different skin irritants (croton oil 10 microL/35 micrograms, dithranol 10 microL/30 micrograms, capsaicin 10 microL/40 micrograms or arachidonic acid to 10 ..
  88. ncbi Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction
    Oliver Kloeters
    Feinberg School of Medicine, Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois, USA
    Wound Repair Regen 15:S40-5. 2007
    ..Our group has developed a unique hypertrophic scar (HS) model in the rabbit ear. The model has been reproducible, quantifiable, and measurable over a time period of 1 month...
  89. pmc Comparative analysis of single-species and polybacterial wound biofilms using a quantitative, in vivo, rabbit ear model
    Akhil K Seth
    Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 7:e42897. 2012
    ..We evaluate and compare the effect of single- and mixed-species biofilm infections on host wound healing dynamics using a quantitative, in vivo, rabbit ear model.
  90. ncbi Distortion-product otoacoustic emissions in schoolchildren: effects of ear asymmetry, handedness, and gender
    T Keogh
    Department of Speech Pathology and Audiology, The University of Queensland, St. Lucia, Australia
    J Am Acad Audiol 12:506-13. 2001
    The present study examined effects of ear asymmetry, handedness, and gender on distortion-product otoacoustic emissions (DPOAEs) obtained from schoolchildren. A total of 1003 children (528 boys and 475 girls), with a mean age of 6...
  91. ncbi The 'red ear syndrome' revisited: two cases and a review of literature
    N Kumar
    Cephalalgia 24:305-8. 2004
  92. doi Ear-acupressure for allergic rhinitis: a systematic review
    C S Zhang
    WHO Collaborating Centre for Traditional Medicine, RMIT University, Bundoora, Vic, Australia
    Clin Otolaryngol 35:6-12. 2010
    ..Allergic rhinitis affects 10-40% of the population globally with a substantial health and economic impact on the community...
  93. ncbi A separate procedure of fusion and activation in an ear fibroblast nuclear transfer program improves preimplantation development of bovine reconstituted oocytes
    S J Shin
    Department of Theriogenology, College of Veterinary Medicine, Seoul National University, Korea
    Theriogenology 55:1697-704. 2001
    ..whether preimplantation development of bovine ("HanWoo," Bos Taurus corcanae) oocytes reconstituted with ear fibroblasts could be improved by a modified procedure of fusion and activation...
  94. pmc Peripheral nerve regeneration in the MRL/MpJ ear wound model
    Gemma Buckley
    Faculty of Life Sciences, UK Centre for Tissue Engineering, University of Manchester, Manchester, UK
    J Anat 218:163-72. 2011
    The MRL/MpJ mouse displays an accelerated ability to heal ear punch wounds without scar formation (whereas wounds on the dorsal surface of the trunk heal with scar formation), offering a rare opportunity for studying tissue regeneration ..
  95. doi A new semi-implantable transcutaneous bone conduction device: clinical, surgical, and audiologic outcomes in patients with congenital ear canal atresia
    Ralf Siegert
    Department of Oto Rhino Laryngology, Head and Neck Surgery, Prosper Hospital, Recklinghausen, Germany
    Otol Neurotol 34:927-34. 2013
    ..The goal of this study was to evaluate its clinical and audiologic results in patients with unilateral or bilateral congenital aural atresia...
  96. ncbi Red ear syndrome
    R Allan Purdy
    Division of Neurology, Department of Medicine, Dalhousie University, QEII Health Sciences Center, Halifax, Nova Scotia, B3H 3Y9, Canada
    Curr Pain Headache Rep 11:313-6. 2007
    The red ear syndrome is a rare syndrome originally described by Lance in 1994...
  97. pmc The red ear syndrome
    A Donnet
    J Neurol Neurosurg Psychiatry 75:1077. 2004
  98. ncbi Ear and kidney syndromes: molecular versus clinical approach
    Hassane Izzedine
    Department of Nephrology, Pitie Salpetriere Hospital, Paris, France
    Kidney Int 65:369-85. 2004
    The association between ear and kidney anomalies is not usually due to an insult to the embryo...
  99. pmc Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:2896-901. 2012
    The ear detects sounds so faint that they produce only atomic-scale displacements in the mechanoelectrical transducer, yet thermal noise causes fluctuations larger by an order of magnitude...
  100. ncbi Novel schemes for hearing and orientation in insects
    Daniel Robert
    School of Biological Sciences, Woodland Road, University of Bristol, UK
    Curr Opin Neurobiol 12:715-20. 2002
    ..These findings unveil the exquisite analytical capabilities of highly specialized microscale auditory systems...
  101. doi Comparison of ear and chest probes in transcutaneous carbon dioxide pressure measurements during general anesthesia in adults
    Tomoki Nishiyama
    Department of Anesthesiology and Critical Care, Higashi Omiya General Hospital, Saitama, Japan
    J Clin Monit Comput 25:323-8. 2011
    ..Our previous study showed that chest was better than arm for tcPCO(2) monitoring. Recently, the ear probe has been developed...

Research Grants72

  1. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic middle ear infections...
  3. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..In mammals, urea transporters are expressed in a wide array of organs, such as kidney, brain, heart, liver, ear, and testis, suggesting that they play an important role in physiology...
  4. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..Research from our laboratory indicates that cisplatin produces inflammation in the inner ear and this leads to death of cells responsible for transmission of sound in the inner ear...
  5. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..However, little is known of the cellular and molecular processes of the ear that are under their control...
  6. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..health outcomes from April 2007 show that children who are not breastfed suffer increased health problems such as ear infections, lower respiratory tract infections, skin rashes similar to eczema, asthmatic episodes, type I and type ..
  7. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..that contributes to chronic upper respiratory disorders, including chronic sinusitis, allergic rhinitis, middle ear disease, as well as pulmonary disease that contribute to respiratory morbidity and mortality world wide...
  8. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals...
  9. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
    DESCRIPTION: Wideband Clinical Diagnosis and Monitoring of Middle-Ear and Cochlear Function A wideband (WB) acoustic test battery has the potential to improve hearing screening and diagnosis of middle-ear and cochlear dysfunction across ..
  10. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: The long-term goal of this proposal is the diagnosis and treatment of bacterial-induced ear infections. These infections are the most common illnesses in infants and young children.
  11. Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect Hearing
    Michael J Brenner; Fiscal Year: 2013
    ..The experimental work focuses on the molecular mechanisms responsible for oxidative stress injury to the inner ear after treatment with gentamicin, a prototype aminoglycoside...
  12. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    ..In Aim 1, we will continue the identification of neurotransmitters/neuromodulators in hair cells and inner-ear sensory epithelia, with femtomole-sensitive, high-resolution, high-performance liquid chromatography...
  13. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    Mirna Mustapha; Fiscal Year: 2013
    ..There are currently no available clinical cures for hereditary inner ear disease or reliable means of preventing age related hearing loss...
  14. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..If generally applicable to the mammalian ear, as there is every reason to believe it will be, the phenomenon of slow-onset, noise-induced, primary, cochlear-..
  15. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ..with important health problems such as low birth- weight, asthma induction, asthma exacerbation, increased ear and lower respiratory infections, and sudden infant death syndrome...
  16. Structure-function analyses on novel processes of type II vestibular hair cells
    Jennifer S Stone; Fiscal Year: 2013
    ..A major cause of balance disorders is the loss of vestibular hair cells in the inner ear, which convert head movements into electrical signals that are sent to the brain via the vestibular nerve...
  17. Basic Mechanisms in Hearing Loss of Cochlear Origin
    Allen F Ryan; Fiscal Year: 2013
    ..mechanisms of gene silencing will be studied to identify epigenetic limitations on the ability of nonsensory inner ear cells to adopt features of the HC phenotype...
  18. Endothelial-reactive antibodies: a diagnostic test for Susac's syndrome
    WILLIAM JAMES WALDMAN; Fiscal Year: 2011
    ..It appears to result from microangiopathy affecting the precapillary arterioles of the brain, retina, and inner ear. While magnetic resonance imaging (MRI) consistently shows a distinctive white matter disturbance in the corpus ..
  19. Functional characterization of the Bronx waltzer deafness gene
    Botond Banfi; Fiscal Year: 2013
    ..in hair cells and neurons, 4) revealed that alternative splicing of several mRNAs is aberrant in the bv inner ear and that the affected mRNAs encode functionally related genes, 5) showed that the splicing defects are hair-cell ..
  20. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..all organ systems is widely recognized, little attention has been paid to the influences of immunity on the inner ear. Research in human subjects demonstrates that hearing loss is successfully treated with corticosteroids in some ..
  21. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..It has become evident that innate immunity plays an active role in maintenance of the health of the middle ear, and is also actively engaged during otitis media (OM)...
  22. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..infection by inhabiting environmental niches contiguous with the upper respiratory tract, including the middle ear space (otitis media) and the airways in adults with COPD...
  23. Matrix Otopathology
    MICHAEL ANNE NMI GRATTON; Fiscal Year: 2011
    ..play in auditory dysfunction Narrative: This project evaluates the role of basement membranes in the inner ear. The research is performed in a mouse whose inner ear has thickened strial capillary basement membranes...
  24. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..As a pathogen, it spreads to the lungs (pneumonia), the central nervous system (meningitis), and the middle ear (otitis media). Mortality and morbidity due to S. pneumoniae is seen primarily in the very young and elderly...
  25. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Damage to inner ear hair cells is a leading cause of human deafness and balance disorders and affects >10% of the world's population. Mammals cannot regenerate their hair cells...
  26. Cloning &Functional Studies of Deafness Mutations
    Kenneth R Johnson; Fiscal Year: 2013
    ..The mouse is an excellent model for studying human hearing disorders because of the similarities in inner ear anatomy, function, and pathology...
  27. Haemophilus influenzae iron/heme regulon
    Terrence L Stull; Fiscal Year: 2012
    ..influenzae disease. PROJECT NARRATIVE Haemophilus influenzae is a major cause of childhood ear infections and pneumonia in adults who have other conditions, such as cystic fibrosis or HIV/AIDS, predisposing ..
  28. Genetics of Age-Related Hearing Loss
    Kenneth R Johnson; Fiscal Year: 2013
    ..Mice and humans often share the same genes and inner ear pathologies underlying monogenic hearing disorders, so genetic studies of AHL in mice are likely to add ..
  29. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..provided by applicant): Little is known of the inflammatory mechanisms of chronic otitis media that lead to inner ear pathology...
  30. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..often refractory to treatment and inflicts significant morbidity in the form of hearing loss and long-term middle ear dysfunction...
  31. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..inflammation and disease derived from pneumococcal infections are caused by high bacterial burden in the middle ear and other organs. Successful growth of S...
  32. The Effect Of Deafness Associated Mutations on MyosinVIIA Function
    Eva Forgacs; Fiscal Year: 2010
    Myosin VIIA is a cellular motor protein which is expressed in a several tissues including the inner ear and the retina...
  33. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..The overriding hypothesis of this multi-investigator proposal is that the MRL/MpJ mouse, in which ear wounds regenerate, expresses proteins during wound healing that favor regeneration...
  34. CLONING OF THE Hol MUTATION
    Licia Selleri; Fiscal Year: 2009
    ..Additionally, 04/014 mutants exhibit low-set and hypoplastic ear pinnae and their middle ear ossicles are severely affected...
  35. USHERIN: STRUCTURAL AND FUNCTIONAL ANALYSIS
    DOMINIC E COSGROVE; Fiscal Year: 2012
    ..a cellular process that explains the defective development and function of ciliated neuroepithelium in the eye and ear that define Usher syndrome pathology...
  36. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..Following each episode of acute otitis media, fluid remains in the middle ear for weeks to months and is associated with significant hearing deficit, a sequela that in turn can impair language ..
  37. A cell-specific inducible model of hearing loss
    Albert S Edge; Fiscal Year: 2011
    ..Many methods rely on drugs that cause damage to cells in organs other than the ear and therefore lead to unacceptably high rates of mortality...
  38. Myosin 15:Genetics, Pathology and Therapeutic Potential
    Sally A Camper; Fiscal Year: 2013
    Abstract Hereditary inner ear disease is prevalent and has significant implications for quality of life. There is currently no available clinical cure for hereditary inner ear disease...
  39. CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS
    Donald M Caspary; Fiscal Year: 2013
    ..These threshold changes are at least in part, independent of inner ear hair cell loss...
  40. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..in children compromises pulmonary function and contributes to respiratory illness, wheeze, cough, asthma, middle ear disease, and sudden infant death syndrome...
  41. Identifying the Atoh1 targetome in hair cells with deep sequencing
    Andrew K Groves; Fiscal Year: 2013
    ..The most common reason for hearing loss is the death of sensory hair cells in the inner ear. In addition to genetic factors, damage from noise exposure or from certain kinds of antibiotics and chemotherapy ..
  42. 3D Single Fiber Endoscope for Minimally Invasive Surgeries
    Jason Geng; Fiscal Year: 2013
    ..surface imaging capability for minimally invasive surgeries, such as otolaryngology surgeries (access sinus, middle ear, inner ear and skull based surgeries), and eye surgeries and drug placement on optic nerves...
  43. INTRACOCHLEAR ELECTROCHEMICAL GRADIENTS
    Alexander A Spector; Fiscal Year: 2012
    ..There are differences in electrical potential and chemical composition between the fluid compartments of the inner ear and the inside of its cells...
  44. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM), or middle ear infection, is a highly prevalent pediatric disease worldwide, ranking first in reasons why children make physician's office and emergency room visits, undergo ..
  45. Determinants of developing efferent synapses in the mammalian cochlea
    ISABELLE CATHERINA ROUX; Fiscal Year: 2013
    ..In Aim 2, we will use a mouse model lacking a1 nAChR expression in the inner ear, to test for its possible function...
  46. Establishing a neuroprotection model in the nonhuman primate to support translati
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2013
    ..Demetrios Vavvas and colleagues at the Mass Eye and Ear Infirmary (MEEI) have revealed a critical redundant role of mediators of both apoptosis and necrosis in cell death ..
  47. A Test of Leptin's Central Function in Zebrafish
    RICHARD LYLE LONDRAVILLE; Fiscal Year: 2012
    ..as zebra fish embryos with reduced leptin do not absorb yolk, have reduced sensory structures (eyes and inner ear), abnormal notochord, impaired cardiac function and lower metabolic rate...
  48. Mechanics of Inner Ear Hair Bundles
    KIRIAKI DOMENICA KARAVITAKI; Fiscal Year: 2012
    ..Mutation of similar links is known to cause inherited deafness in mice and humans, and this sort of sliding adhesion represents a new type of mechanism in cell biology. ..
  49. Regeneration of stereocilia of cochlear hair cells
    David Z Z He; Fiscal Year: 2010
    The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity...
  50. Preventing hair cell loss by regulating prestin's function
    Jing Zheng; Fiscal Year: 2010
    ..OHCs are also the most vulnerable cells in the inner ear and are involved in a majority of sensorineural hearing loss...
  51. Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Hamed Jafar-Nejad; Fiscal Year: 2013
    ..of the Notch pathway can be of potential therapeutic value in several disease contexts, including inner ear hair cell loss, muscle injury and demyelination...
  52. The Role of Eya4 in Hearing and Disease
    Jonathan G Seidman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Regulation of gene transcription in the ear is critical for normal development and audition...
  53. Novel Approaches for Prevention and Treatment of Noise Induced Hearing loss
    Debashree Mukherjea; Fiscal Year: 2013
    ..Chronic noise exposure leads to irreversible damage to inner ear structures and hearing loss...
  54. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE:Otitis media, or middle ear infection, is a major public health problem in young children both in the US and in the world...
  55. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..are two historical and ubiquitous instruments that largely only illuminate and magnify tissue surfaces in the ear and eye, respectively...
  56. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..technology and (2) to stimulate the auricular branch of the vagus nerve that supplies a dermatome in external ear using needle electrodes...
  57. Bilateral cochlear implants: Physiology and psychophysics
    Bertrand Delgutte; Fiscal Year: 2012
    ..In this application, investigators from the Massachusetts Eye and Ear Infirmary, MIT, and Boston University combine their expertise in psychophysics, neurophysiology and neural ..
  58. Cellular therapy for the inner ear
    Albert S Edge; Fiscal Year: 2013
    ..We use a model system developed for neural replacement in the inner ear to investigate requirements for rebuilding a neural circuit: in the current work we study whether transplanted ..
  59. MOLECULAR BASIS OF INHERITED DEAFNESS
    David P Corey; Fiscal Year: 2013
    ..Thus tip links are a key component at the heart of inner ear function-to turn sound and head movement into neural signals...
  60. Analysis of Hair Cell Regeneration in Zebrafish
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2010
    ..the functional and morphological similarity between the lateral line hair cells and the hair cells of the inner ear;3) its accessibility to direct observation and manipulation throughout development;and 4) the ability to rapidly ..
  61. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..reconstructed middle ears so as to develop better diagnostic tests and surgical procedures for patients with middle-ear disease...
  62. Mechanisms of Sensory Regeneration
    Mark Warchol; Fiscal Year: 2013
    ..Normal sensory function of the inner ear relies on mechanoreceptive hair cells, which convert sound vibrations and head movements into electrical signals ..
  63. Ear Biomechanics for Restoration of Hearing
    RONG GAN; Fiscal Year: 2009
    ..applicant): The long-term goal of this project is to determine how the structure and mechanical properties of human ear affect acoustic-mechanical transmission through the external ear canal and middle ear to inner ear (or cochlea) in ..
  64. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    ..Sensitive hair cell function is dependent on a structurally and physiologically intact ear. Thus, studies to determine mechanisms of ototoxicity have used intact animals, or inner ear explants excised from ..
  65. Development of a laser holography otoscope for diagnosis in the clinic
    John J Rosowski; Fiscal Year: 2010
    Conductive hearing loss, usually associated with middle-ear disorders, is the most common reason for otologic surgery...
  66. Dx Ear: An automated tool for diagnosis of otitis media
    JELENA KOVACEVIC; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Otitis media is a general term for middle-ear inflammation that is classified clinically as either acute otitis media (AOM) or otitis media with effusion (OME)...
  67. Ear Canal Optical Coherent Tomography System
    PAUL SHNITSER; Fiscal Year: 2010
    ..Physical Optics Corporation proposes development of a new Ear Canal Optical Coherent Tomography (ECOCT) system to obtain the shape of the individual ear canal and the ..
  68. AMPLIFICATION, MIDDLE EAR PATHOLOGY AND ACADEMIC SUCCESS
    NICKOLA NELSON; Fiscal Year: 1993
    ..concept comprehension, and teacher ratings of educational risk among first grade children with and without middle ear pathology (measured by repeated tympanometric and pure-tone screening procedures using ASHA, 1990, guidelines)...
  69. BIOMECHANICS OF THE MIDDLE EAR
    THOMAS HETHERINGTON; Fiscal Year: 1990
    The amphibian ear has been extensively studied and used as a general model of the vertebrate auditory system, but much remains to be understood of an important component of the amphibian middle ear, the opercularis system...
  70. HUMAN MIDDLE EAR--FORWARD AND REVERSE SOUND TRANSMISSION
    Sunil Puria; Fiscal Year: 2002
    This project seeks to characterize forward and reverse sound transmission through the human middle ear. One of the most significant discoveries in hearing during the past twenty years has been that a healthy ear not only detects sound ..
  71. The Ear-Brain System: Approaches to the Study and Treatment of Hearing Loss
    Gabrielle Saunders; Fiscal Year: 2009
    ..The purpose of this grant application is to request funding for the upcoming 4th Biennial Conference titled "The Ear-Brain System: Approaches to the Study and Treatment of Hearing Loss...
  72. The Daily Interactions of Couples Coping With Breast Cancer: With Whom, About Wha
    Matthias R Mehl; Fiscal Year: 2010
    ..study tests the potentials of a novel momentary assessment method, called the Electronically Activated Recorder (EAR), for studying real-world communication processes in couples coping with breast cancer...