Genomes and Genes
Summary: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Publications189 found, 100 shown here
- Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse tracheaRainer Schreiber
Institut fur Physiologie, Universitat Regensburg, Germany
Cell Physiol Biochem 16:99-108. 2005..Here we show that these metabolites change electrolyte transport by stimulation of P2Y6 receptors in mouse trachea. Immunohistochemistry confirmed luminal and basolateral expression of P2Y6 receptors...
- The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epitheliumEmma L Rawlins
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Cell Stem Cell 4:525-34. 2009..In the trachea, Clara cells give rise to ciliated cells but do not self-renew extensively...
- Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigsNam Soo Joo
Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
J Clin Invest 120:3161-6. 2010..These data are a step toward determining whether gland secretory defects contribute to CF airway disease...
- Ultrasound-guided percutaneous dilatational tracheostomy: a safe method to avoid cranial misplacement of the tracheostomy tubeA Sustic
Department of Anaesthesiology and ICU, University Hospital Rijeka, Croatia
Intensive Care Med 26:1379-81. 2000..05) and four (36%) patients had a broken tracheal ring (P = NS). The authors maintain that by using ultrasound-guided PDT cranial misplacement of the tracheostomy tube may be entirely avoided...
- Early restriction of peripheral and proximal cell lineages during formation of the lungAnne-Karina T Perl
Cincinnati Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229-3039, USA
Proc Natl Acad Sci U S A 99:10482-7. 2002..Extensive or complete labeling of peripheral lung, thyroid, and thymic epithelia, but not trachea, bronchi, or gastrointestinal tract occurred when mice were exposed to doxycycline from embryonic day (E) 4...
- The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extensionL Glazer
Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
Genes Dev 5:697-705. 1991..However, the extension of tracheal cell processes leading to the formation of the elaborate tree structure is blocked. The DFGF-R protein may thus participate in receiving spatial cues that guide tracheal cell outgrowth...
- Analysis of component findings in 79 patients diagnosed with VACTERL associationBenjamin D Solomon
Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Am J Med Genet A 152:2236-44. 2010..These findings have implications for both our understanding of VACTERL association and for the approach to research involving this condition...
- Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell deathKatrin Anne Becker
Dept of Molecular Biology, University of Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Biochem Biophys Res Commun 403:368-74. 2010..In this study we investigated whether ceramide concentrations are also altered in the trachea and the intestine of cystic fibrosis mice and whether an accumulation of ceramide in these organs has functional ..
- A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit tracheaK Iizuka
First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
Br J Pharmacol 128:925-33. 1999..5'-O-(3-thiotriphosphate) (GTPgammaS)-induced contraction in alpha-toxin- or beta-escin-permeabilized rabbit trachea. 2 Although pre-treatment with Y-27632 dose-dependently inhibited GTPgammaS (10 microM)-induced Ca2+ ..
- The replicase gene of avian coronavirus infectious bronchitis virus is a determinant of pathogenicityMaria Armesto
Division of Microbiology, Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire, United Kingdom
PLoS ONE 4:e7384. 2009....
- cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airwaysRobert J Lee
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6085, USA
J Clin Invest 120:3137-48. 2010..These results identify important molecular mechanisms of cAMP-dependent secretion, including a requirement for Ca2+ signaling, and suggest new therapeutic approaches to correct defective submucosal gland secretion in CF...
- sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airwaysN Hacohen
Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
Cell 92:253-63. 1998..sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development...
- Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in DrosophilaDominique Förster
Institute of Zoology, Universitat Zurich, CH 8057 Zurich, Switzerland
Curr Biol 20:62-8. 2010..These results indicate a critical role of membrane-associated proteins in the process and imply a mechanism that coordinates autonomous behaviors of individual cells within epithelial structures...
- Morphogenesis of the trachea and esophagus: current players and new roles for noggin and BmpsJianwen Que
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Differentiation 74:422-37. 2006..endoderm, the folding of the endoderm into a foregut tube, and the subsequent separation of the foregut tube into trachea and esophagus...
- Lung epithelial cells release ATP during ozone exposure: signaling for cell survivalShama Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 39:213-26. 2005..Thus, extracellularly released ATP signals to prevent ozone-induced death and supplementation with ATP or its analogs can augment protection, at least in part via Akt and /or ERK signaling pathways and their metabolic effects...
- A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila tracheaMonn Monn Myat
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Dev Biol 281:38-52. 2005..These studies support a model in which both the Dpp- and the FGF-signaling pathways control expression of knirps and knirps-related, thereby regulating cell migration during dorsal branch formation...
- Tubulogenesis: an inside jobLianna E Swanson
Northwestern University, Evanston, Illinois 60208-3500, USA
Curr Biol 16:R51-3. 2006
- boudin is required for septate junction organisation in Drosophila and codes for a diffusible protein of the Ly6 superfamilyAssia Hijazi
Université de Toulouse UPS, Centre de Biologie du Developpement, CNRS UMR 5547, Bâtiment 4R3, 118 route de Narbonne, F 31062 Toulouse, France
Development 136:2199-209. 2009..Our work opens the way for future studies addressing the function of Ly6 proteins using Drosophila as a model system...
- The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine tracheaF Grahammer
Institute of Physiology, Albert Ludwigs Universitat, Hermann Herder Strabetae 7, D 79104 Freiburg, Germany
J Biol Chem 276:42268-75. 2001..As described for colonic epithelium, the current through KCNQ1 complexes in murine trachea is specifically inhibited by the chromanol 293B...
- H5N1 Virus Attachment to Lower Respiratory TractDebby van Riel
Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
Science 312:399. 2006..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
- Tracheal agenesis revisited: analysis of associated anomaliesJ A Evans
Department of Human Genetics, University of Manitoba and Children s Hospital, Winnipeg, Canada
Am J Med Genet 82:415-22. 1999..Anomalies in the first group were primarily restricted to the trachea, larynx, and cardiovascular system...
- A composite tissue-engineered trachea using sheep nasal chondrocyte and epithelial cellsKoji Kojima
Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, Massachusetts, USA
FASEB J 17:823-8. 2003..Implants were harvested 4 wk later and analyzed. The morphology of implants resembles that of native sheep trachea. H&E staining shows the presence of mature cartilage and formation of a pseudo-stratified columnar epithelium,..
- Where's the tube? Evaluation of hand-held ultrasound in confirming endotracheal tube placementRosaleen Chun
Department of Anesthesia, Foothills Medical Centre, Calgary, Alberta, Canada
Prehosp Disaster Med 19:366-9. 2004..Thoracic sonography, previously utilized to detect pneumothoraces, has not been tested to assess ETT placement...
- A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cellsCharlotte K Billington
Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK
Am J Respir Cell Mol Biol 38:1-7. 2008..These data suggest that PDE4D5, despite being a minor component of the tissue PDE pool, is the key physiological regulator of beta(2)AR-induced cAMP turnover within human airway smooth muscle...
- Differentiated cultures of primary hamster tracheal airway epithelial cellsRegina K Rowe
Molecular Microbiology and Microbial Pathogenesis Graduate Program, Washington University School of Medicine, St. Louis, Missouri 63110, USA
In Vitro Cell Dev Biol Anim 40:303-11. 2004....
- beta-Catenin promotes respiratory progenitor identity in mouse foregutKelley S Harris-Johnson
Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 106:16287-92. 2009The mammalian respiratory system, consisting of both trachea and lung, initiates from the foregut endoderm. The molecular program that instructs endodermal cells to adopt the respiratory fate is not fully understood...
- Postoperative necrosis of the anterior part of the cervical trachea following thyroidectomySebastien Jacqmin
J Anesth 19:347-8. 2005
- Agreement between quantitative cultures of postintubation tracheal aspiration and plugged telescoping catheter, protected specimen brush, or BAL for the diagnosis of nosocomial pneumoniaChristophe Clec'h
Service de Reanimation, Hopital Avicenne, 125, route de Stalingrad, 93009 Bobigny Cedex, France
Chest 130:956-61. 2006..Our aim was to compare the diagnostic accuracy of PITA to that of PSB, BAL, or PTC in patients requiring MV for suspected NP...
- Tissue engineered cartilage generated from human trachea using DegraPol scaffoldLin Yang
Division of Thoracic Surgery, Laboratory of Tissue Engineering, University Hospital, Raemistrasse 100, CH-8091 Zurich, Switzerland
Eur J Cardiothorac Surg 24:201-7. 2003..METHODS: Human tracheal cartilage was harvested from the trachea of lung donors, digested in 0.3% collagenase II, and the condrocytes serially passaged every 7-9 days...
- Analysis of FOXF1 and the FOX gene cluster in patients with VACTERL associationNneamaka B Agochukwu
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 35, Room 1B207, 35 Convent Drive MSC 3717, Bethesda, MD 20892 3717, United States
Eur J Med Genet 54:323-8. 2011....
- Evaluation of the anti-asthmatic property of Asystasia gangetica leaf extractsP A Akah
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Enugu State, Nsukka, Nigeria
J Ethnopharmacol 89:25-36. 2003..The study justified the use of the leaf of Asystasia gangetica in the management of asthma in Nigerian folk medicine...
- Vasoactive intestinal peptide stimulates mucus secretion, but nitric oxide has no effect on mucus secretion in the ferret tracheaJung-Soo Kim
Dept. of Pediatrics, Wake Forest Univ. School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
J Appl Physiol 101:486-91. 2006..The purpose of this study was to determine the effect of VIP on mucus secretion in the ferret trachea and if this effect was influenced by NO...
- Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor alpha-mediated smooth airway muscle dysfunctionF Aimbire
Institute of Research and Development-IP and D/UNIVAP Av, Shsima Hifumi 2911, , , Brazil
Lasers Surg Med 38:773-8. 2006..To investigate if LLLT could reduce impairment in inflamed trachea smooth muscles (TSM) in rats...
- Tissue engineered epithelial cell sheets for the creation of a bioartificial tracheaMasato Kanzaki
The Department of Surgery I, Tokyo Women's Medical University, Tokyo, Japan
Tissue Eng 12:1275-83. 2006..These results therefore demonstrate that these tracheal epithelial cell sheets can create an epithelial lining on the luminal surface of a bioartificial trachea.
- Latent Human Papillomavirus infection is comparable in the larynx and tracheaAllan L Abramson
Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
J Med Virol 72:473-7. 2004..There was no significant difference in prevalence of latent HPV DNA between larynx and trachea, analyzing either those patients with a single biopsy or those with more than one biopsy of larynx, trachea, or ..
- Diagnosis of ventilator-associated pneumonia: focus on nonbronchoscopic techniques (nonbronchoscopic bronchoalveolar lavage, including mini-BAL, blinded protected specimen brush, and blinded bronchial sampling) and endotracheal aspiratesShigeki Fujitani
Department of Critical Care Medicine, University of Pittsburgh, PA 15240, USA
J Intensive Care Med 21:17-21. 2006..Pending future studies, use of endotracheal aspirates without the use of quantitation seems to be a reasonable approach for clinicians who are not committed to an invasive procedure...
- Ultrasound-guided percutaneous dilatational tracheostomy with laryngeal mask airway control in a morbidly obese patientAlan Sustic
Department of Anesthesiology and ICU, University Hospital Rijeka, Rijeka, Croatia
J Clin Anesth 16:121-3. 2004..Possible advantages of an ultrasonography-guided method and LMA control in morbidly obese patients also are discussed...
- Characterization of the prostaglandin E2 sensitive (EP)-receptor in the rat isolated tracheaS J Lydford
Department of Pharmacology, Fisons plc, Pharmaceutical Division, Loughborough, Leicestershire
Br J Pharmacol 112:133-6. 1994..range of natural and synthetic prostanoid receptor agonists and antagonists, we have shown that the rat isolated trachea contains a heterogeneous population of prostaglandin receptor sub-types mediating both relaxation and contraction ..
- Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of beta(2)-adrenoceptorsYoshio Tanaka
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Science, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
J Smooth Muscle Res 41:153-61. 2005..adrenaline-induced relaxation was pharmacologically identified in smooth muscle cells of the isolated guinea-pig trachea. Adrenaline produced a concentration-dependent relaxation with a pD(2) value of 7.1...
- Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivoHeather MacPherson
MRC Human Genetics Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK
J Cell Sci 118:2441-50. 2005..that mice engrafted with side population cells have donor-derived cells present in the epithelial lining of the trachea following damage and repair. Donor-derived cells were found at a frequency of 0.83%...
- Nontraumatic disruption of the fibrocartilaginous trachea: causes and clinical outcomesMichelle R Aerni
Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
Chest 130:1143-9. 2006BACKGROUND: Nontraumatic disruption of the fibrocartilaginous trachea is rare, and the appropriate management of this condition is not well-characterized...
- Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glandsMonal Khansaheb
Cystic Fibrosis Research Laboratory, Stanford Univ, CA 94305 2130, USA
Am J Physiol Lung Cell Mol Physiol 300:L370-9. 2011..These and prior results suggest that SubP stimulates pig gland secretion via CFTR- and Ca(2+)-activated Cl(-) channels...
- Anatomy of the trachea, carina, and bronchiDouglas J Minnich
Division of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Blake 1570, Boston, MA 02114, USA
Thorac Surg Clin 17:571-85. 2007..In addition, the more precise delineation of tracheal anatomy has contributed largely to the advancement of airway surgery in recent years. This article serves as a foundation for learning or reviewing this important topic...
- Amino acid 226 in the hemagglutinin of H4N6 influenza virus determines binding affinity for alpha2,6-linked sialic acid and infectivity levels in primary swine and human respiratory epithelial cellsAllen C Bateman
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Virol 82:8204-9. 2008..Using specific neuraminidases, we found that irrespective of their relative binding preferences, all of the influenza viruses examined utilized SAalpha2,6Gal to infect swine and human cells...
- Epithelial mucin genesS J Gendler
Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA
Annu Rev Physiol 57:607-34. 1995....
- TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse tracheaTatjana I Kichko
Department of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
Eur J Neurosci 29:1896-904. 2009..An isolated mouse trachea preparation was established to measure chemically and thermally stimulated CGRP release as an index for sensory ..
- Role of potassium channels in the relaxant effect of levosimendan in guinea pig tracheal preparationsBilsen Eksert
Department of Pharmacology, Akdeniz University, Medical Faculty, Antalya, Turkey
Pharmacol Rep 61:275-80. 2009..The present findings suggested that the relaxant effect induced by levosimendan might be partially due to K(ATP) and BK Ca in isolated guinea pig tracheal rings...
- Basal cells as stem cells of the mouse trachea and human airway epitheliumJason R Rock
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 106:12771-5. 2009The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14...
- Bedside ultrasound screening for pretracheal vascular structures may minimize the risks of percutaneous dilatational tracheostomyAlexander C Flint
Neurocritical Care and Pulmonary Critical Care, Head and Neck Surgery, Kaiser Permanente, 1150 Veterans Blvd, Redwood City, CA 94063, USA
Neurocrit Care 11:372-6. 2009..Here, we present a description of ultrasound technique and two case examples to show the utility of bedside ultrasound screening to select patients with appropriate anatomy for PDT...
- Post-intubation tracheal injury: report of three cases and literature reviewCarlos Remolina Medina
Pavilhão Pereira Filho, Complexo Hospitalar Santa Casa, Porto Alegre, RS, Brasil
J Bras Pneumol 35:809-13. 2009..We report the cases of three patients presenting tracheal laceration due to traumatic orotracheal intubation, two submitted to surgical treatment and one submitted to conservative treatment...
- Anatomical variation in the position of the brachiocephalic trunk (innominate artery) with respect to the trachea: a computed tomography-based study and literature review of Innominate Artery Compression SyndromeS L Fawcett
Department of Radiology, Cambridge University Teaching Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
Clin Anat 23:61-9. 2010..has been controversially attributed to an anomalous origin of this vessel to the left of, and hence crossing, the trachea. The aim of this study was to establish the normal relationship between the BT and trachea in infants, children, ..
- Mucus secretion from individual submucosal glands of the ferret tracheaHyung Ju Cho
Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
Am J Physiol Lung Cell Mol Physiol 299:L124-36. 2010..These results provide parametric data for comparison with fluid secretion from glands in ferrets lacking CFTR...
- 5q11.2 deletion in a patient with tracheal agenesisElisabeth M de Jong
Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
Eur J Hum Genet 18:1265-8. 2010..No common deletions or duplications are found in our cohort, suggesting that TA is a genetically heterogeneous disorder...
- A simple method to predict pretracheal tissue thickness to prevent accidental decannulation in the obeseChristopher Szeto
Department of Otolaryngology Head and Neck Surgery, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Otolaryngol Head Neck Surg 143:223-9. 2010..Our purpose was to 1) establish the range of trachea-to-skin soft tissue thickness (TTSSTT) in obese patients and 2) determine which easily obtained anthropometric ..
- Long-term outcomes of adults with features of VACTERL associationManu S Raam
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 35, Room 1B207, 35 Convent Drive MSC 3717, Bethesda, MD 20892 3717, USA
Eur J Med Genet 54:34-41. 2011....
- The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearanceN Wienkötter
Department of Pharmacology, Institute of Medicinal Chemistry, Munster, Germany
Planta Med 74:105-8. 2008NIGELLA SATIVA L. has many effects including those on the gastrointestinal tract and trachea and is, therefore, used in the Mediteranean area and in India/Pakistan...
- The expiration reflex from the trachea and bronchiM Tatar
Dept of Pathophysiology, Faculty of Medicine, Comenius University, Martin, Slovakia
Eur Respir J 31:385-90. 2008..Its existence should be taken into account in experimental, and possibly clinical, studies on tracheobronchial cough...
- Ultrasound-guided localisation of the tracheaJ A Orr
Anaesthesia 62:972-3. 2007
- Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitorsJenny Hallgren
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:20478-83. 2007..Thus, these studies demonstrate a role for a chemokine receptor in regulating endothelial VCAM-1 expression, MCp migration, and the level of intraepithelial MC in the lung of aerosolized, antigen-challenged mice...
- Cholinergic chemosensory cells in the trachea regulate breathingGabriela Krasteva
Institute of Anatomy and Cell Biology and Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen D 35385, Germany
Proc Natl Acad Sci U S A 108:9478-83. 2011..Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (α-gustducin, phospholipase C(β2)..
- The gross anatomy of larynx, trachea and syrinx in the long-legged buzzard (Buteo rufinus)M Kabak
Department of Anatomy, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Kurupelit Samsun, Turkey
Anat Histol Embryol 36:27-32. 2007..The partially ossified corpus and ala of the cricoid cartilage were connected with cartilaginous plate. Trachea was formed up of complete cartilage circles...
- MDCT of the central airways: comparison with bronchoscopy in the evaluation of complications of endotracheal and tracheostomy tubesMaryellen Sun
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Thorac Imaging 22:136-42. 2007..To evaluate the accuracy of multidetector row computed tomography (MDCT) compared with bronchoscopy in the assessment of airway complications related to endotracheal and tracheostomy tubes...
- Hyperresponsiveness of bronchial but not tracheal smooth muscle in a murine model of allergic bronchial asthmaY Chiba
Department of Pharmacology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
Inflamm Res 53:636-42. 2004....
- Protective effects of tiotropium bromide in the progression of airway smooth muscle remodelingReinoud Gosens
Department of Molecular Pharmacology, University Centre for Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
Am J Respir Crit Care Med 171:1096-102. 2005....
- Attachment of columnar airway epithelial cells in asthmaEyman Shebani
Department of Medical Cell Biology, University of Uppsala, Box 571, SE-75123 Uppsala, Sweden
Tissue Cell 37:145-52. 2005..It is concluded that attachment of columnar cells to the basal lamina occurs mainly indirectly, via desmosomal attachment to basal cells, and that direct attachment of columnar cells to the basal lamina is weakened in asthmatics...
- Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscleE Rousseau
Department of Physiology and Biophysics, Facluty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Am J Physiol Lung Cell Mol Physiol 288:L460-70. 2005....
- Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vesselsKristina Rydell Törmänen
Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
Am J Respir Crit Care Med 171:19-25. 2005..The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation...
- 8-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinaseKatsuaki Endou
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
Am J Physiol Lung Cell Mol Physiol 287:L641-8. 2004..In rabbit trachea, CCh-induced smooth muscle contraction was inhibited by 8-BrcAMP and Y-27632 to a similar extent...
- 5-Oxo-ETE regulates tone of guinea pig airway smooth muscle via activation of Ca2+ pools and Rho-kinase pathwayFrederic Mercier
Le Bilarium, Department of Physiology and Biophysics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada
Am J Physiol Lung Cell Mol Physiol 287:L631-40. 2004....
- Effect of nitric oxide synthases inhibitors on exogenous irritant-induced bronchial hyper-reactivity in guinea pigsM Antosova
Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Sklabinska 26, 037 53 Martin, Slovakia
Gen Physiol Biophys 25:137-47. 2006..A more significant effect was recorded after the pre-treatment with non-selective inhibitor L-NAME. The results showed possible participation of constitutive forms of NOS in the BHR...
- Successful lung isolation with one bronchial blocker in a patient with tracheal bronchusNobuhide Kin
Anesth Analg 98:270. 2004
- Insulin induces airway smooth muscle contractionD Schaafsma
Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
Br J Pharmacol 150:136-42. 2007..For regular use, it is critical that airway function remains unimpaired in response to insulin exposure...
- Ontogeny of airway smooth muscle: structure, innervation, myogenesis and function in the fetal lungMalcolm P Sparrow
Department of Medicine, Asthma and Allergy Research Institute, University of Western Australia, Nedlands 6009, Australia
Respir Physiol Neurobiol 137:361-72. 2003..form into interlocking bundles that progressively become wider and more compact along the bronchial tree to the trachea. Their orientation is perpendicular to the long axis of the airway. The ASM exhibits rhythmic contractility (i.e...
- Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigsM Brozmanova
Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
J Physiol Pharmacol 58:57-65. 2007..8(6-10); P=0.049], whereas there was no significant increase in the cough response tested in the late allergic phase. A correlation between the cough intensity and the number of eosinophils from nasal mucosa only (P=0.008) was found...
- Slide tracheobronchoplasty in an infantEmmanuel Le Bret
, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
J Thorac Cardiovasc Surg 132:181-3. 2006
- Agonist-independent alteration in beta-adrenoceptor-G-protein-adenylate cyclase system in an equine model of recurrent airway obstructionGetu Abraham
Institute of Pharmacology, Pharmacy and Toxicology, Leipzig University, Germany
Pulm Pharmacol Ther 19:218-29. 2006We examined the inhibitory sympathetic beta-adrenergic mechanisms in peripheral lung, bronchi and trachea of an equine model of recurrent airway obstruction (RAO), to support the hypothesis that the beta-adrenergic receptor dysfunction ..
- [Functional characteristics of rat tracheal and bronchial smooth muscle at different stages of alveolitis.]A N Fedin
Zh Evol Biokhim Fiziol 42:57-62. 2006
- Inhibition of guanylyl cyclase in the airways hyperreactivityM Antosova
Department of Pharmacology, Comenius University, Jessenius Faculty of Medicine, Martiln, Slovakia
Bratisl Lek Listy 106:243-7. 2005..The majority of nitric oxide (NO) effects in the respiratory system are mediated via the stimulation of soluble guanylyl cyclase with subsequent generation of the second messenger--cyclic guanosine monophosphate (cGMP)...
- Histamine H1-receptor antagonists inhibit nuclear factor-kappaB and activator protein-1 activities via H1-receptor-dependent and -independent mechanismsC Roumestan
INSERM, U454, Montpellier, France
Clin Exp Allergy 38:947-56. 2008..Mizolastine is also an inhibitor of 5-lipoxygenase (5-LO), an enzyme that has been involved in NF-kappaB activation...
- Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulationJeffrey W Card
Division of Intramural Research, National Institute of Environmental Health Sciences, 111 T W Alexander Dr, Bldg 101, Rm D236, Research Triangle Park, NC 27709, USA
Am J Physiol Lung Cell Mol Physiol 292:L908-14. 2007..Together, these data indicate that male sex hormones promote cholinergic airway responsiveness via a vagally mediated reflex mechanism that may be important in the regulation of airway tone in the normal and diseased lung...
- Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigsNaomi Takayama
Department of Intensive and Critical Care Medicine, Dokkyo University School of Medicine, Tochigi, Japan
J Smooth Muscle Res 41:257-70. 2005..Sivelestat may be effective in reducing the airway hyperresponsiveness to tachykinins induced by epithelial injury as occurs in LPS-mediated inflammatory lung diseases...
- Mechanical plasticity and contractile properties of airway smooth muscleAnita Fust
Department of Physiology, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 83:865-8. 2005..This review also focuses on the relevance of smooth muscle plasticity in asthma, but it is important to remember that there are other places where smooth muscle plasticity may play an equally important role...
- The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropyVictoria Boswell-Smith
The Sackler Institute of Pulmonary Pharmacology, King's College London School of Biomedical and Health Sciences, Division of Pharmaceutical Sciences, London SE1 1UL, UK
J Pharmacol Exp Ther 318:840-8. 2006..RPL565 (25%) in micronized lactose significantly inhibited histamine-induced plasma protein extravasation in the trachea and histamine-induced bronchoconstriction over a 5.5-h period...
- [Alteration of trachea and bronchi smooth muscles constriction under long inhalation of dioxide nitrogen by rats]A N Fedin
Ross Fiziol Zh Im I M Sechenova 93:1163-70. 2007On insulated preparation of trachea and bronchi, change of the smooth muscles constriction was studied in rats inhaling dioxide nitrogen during 15, 30 and 60 days. The inhalation enhanced 1.5-fold and bronchi 2...
- Modulation of the contractile responses of guinea pig isolated tracheal rings after chronic intermittent hypobaric hypoxia with and without cold exposureKaveri Chakrabarty
Dept. of Physiology, Vallabhbhai Patel Chest Institute, Univ. of Delhi, Delhi-110007, India
J Appl Physiol 99:1006-11. 2005..The data demonstrate that intermittent exposure to hypoxia profoundly influences contractile response of tracheal smooth muscle, and cold exposure can further modulate the response, implying the importance of cold at high altitude...
- [Functional disturbances in the nervous structures of the respiratory tract in rats following nitrogen dioxide inhalation]A N Fedin
Ross Fiziol Zh Im I M Sechenova 93:1071-7. 2007..The processing of trachea and bronchus preparations by prednisolon (1-10 microg/ml) decreased muscle reactions to 12% only at nerve ..
- Human airway smooth muscle cells express the high affinity receptor for IgE (Fc epsilon RI): a critical role of Fc epsilon RI in human airway smooth muscle cell functionAbdelilah Soussi Gounni
Department of Immunology, Section of Respiratory Diseases, Faculty of Medicine, University of Manitoba, Winnipeg Canada
J Immunol 175:2613-21. 2005..Taken together, these results suggest a potential new and important mechanism by which ASM cells may participate in airway inflammation and bronchoconstriction associated with allergic asthma...
- Effect of NO-synthase and arginase inhibition in airway hyperreactivityA Strapkova
Department of Pharmacology, Comenius University, Jessenius Faculty of Medicine, Martin, Slovakia
Bratisl Lek Listy 109:191-7. 2008..The decreased L-arginine bioavailability, the basic substrate for nitric oxide synthesis, can be one of the factors contributing to the airways hyperreactivity...
- Inhibitory effects of putative peptidic urotensin-II receptor antagonists on urotensin-II-induced contraction of cat isolated respiratory smooth muscleDavid J Behm
Department of Vascular Biology UW2510, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, P O Box 1539, 709 Swedeland Road, King of Prussia, Pa 19406 0939, USA
Eur J Pharmacol 516:276-81. 2005..transcription polymerase chain reaction (RT-PCR) analysis indicated the presence of UT receptor mRNA in cat trachea, bronchi and lung parenchyma...
- Relation of L-arginine to airway hyperreactivityA Strapkova
Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Sklabinska 26, 037 53 Martin, Slovakia
Gen Physiol Biophys 27:85-91. 2008..The effect of supplementation was different depending on airway level and pre-treatment duration. The results refer to the importance of optimal L-arginine level for the control of bronchomotoric tone...
- Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airwaysMarcello Trevisani
Center of Excellence for the Study of Inflammation, University of Ferrara, Ferrara, Italy
Br J Pharmacol 145:1123-31. 2005..This novel mechanism may contribute to the irritative action of H(2)S in the respiratory system...
- Maturational changes in airway smooth muscle shortening and relaxation. Implications for asthmaP Chitano
Department of Pediatrics, Room 302, Bell Building, Box 2994, Duke University Medical Center, Durham, NC 27710, USA
Respir Physiol Neurobiol 137:347-59. 2003..It remains to be determined the role of these ASM properties in the onset of childhood asthma and whether specific alterations are induced by the occurrence of obstructive airway diseases in young individuals...
- MAPK regulation of gene expression in airway smooth muscleWilliam T Gerthoffer
Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557 0270, USA
Respir Physiol Neurobiol 137:237-50. 2003..These events thereby contribute to normal airway function and participate in pathological changes in ASM that accompany symptoms of asthma...
- Functional characterization of muscarinic receptors in murine airwaysJ Garssen
Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands
Br J Pharmacol 109:53-60. 1993..It is therefore likely that an M3/M2 receptor balance plays an important role in the regulation of airway function...
- Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?Luke J Janssen
Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002..Also, we will examine some novel ionic mechanisms in the context of Ca(2+) handling and excitation-contraction coupling in ASM...
- Relaxation of guinea pig trachealis during electrical field stimulation increases with agePasquale Chitano
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
J Appl Physiol 92:1835-42. 2002..We suggest that a reduced ASM relaxing ability during stimulation may be involved in juvenile airway hyperresponsiveness...
- Electrical stimulation-induced alpha1- and alpha2-adrenoceptors-mediated contractions of isolated canine lymph nodesFumitaka Ikomi
The 1st Department of Physiology, Shinshu University School of Medicine, Matsumoto, Japan
Auton Neurosci 96:85-92. 2002....
- Iatrogenic ruptures of the tracheobronchial treeH S Hofmann
Department of Cardio Thoracic Surgery, Martin Luther University Halle Wittenberg, E Grube Str 40, 06097 Halle, Germany
Eur J Cardiothorac Surg 21:649-52. 2002..Therefore, we evaluated the reasons, the subsequent therapy and the outcome of patients with tracheal rupture, who were admitted to our hospital...
- Xenograft model of the CF airwayMohammed Filali
Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, IA, USA
Methods Mol Med 70:537-50. 2002
- Bronchodilator activity of Mikania glomerata Sprengel on human bronchi and guinea-pig tracheaR Soares de Moura
Departamento de Farmacologia, IB UERJ, Rio de Janeiro, Brasil
J Pharm Pharmacol 54:249-56. 2002..Aqueousextracts and HAE induced a significant inhibition on the histamine contractions on the isolated guinea-pig trachea. HAE extract induced a concentration-dependent relaxation on guinea-pig trachea pre-contracted with histamine (..
- [Interactions of histamine and glucocorticoids with nerve structures of respiration passages]A N Fedin
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci, St. Petersburg, 194223, pr. M. Toreza, 44, Russia
Ross Fiziol Zh Im I M Sechenova 87:1413-21. 2001..This investigation involved study of the interaction mechanisms between histamine and dexamethasone, on one hand, and intramural neural structures, on the other hand...
- Nasal dosimetry of diacetyl and butyric acid vaporsJohn Morris; Fiscal Year: 2005..to diacetyl (2,3 butadiene), a major component of butter flavoring vapors, results in necrosis of the nasal and trachea, but not the intrapulmonary airways...
- Neuromuscular blocker-induced asthma during anesthesiaCharles Emala; Fiscal Year: 2006..During intubation of the trachea, parasympathetic nerves release acetylcholine that act on M3 muscarinic receptors on airway smooth muscle to ..
- CT Diagnosis of Tracheomalacia in Patients with COPDPhillip Boiselle; Fiscal Year: 2009..Acquired tracheomalacia, a condition defined by excessive expiratory collapse of the trachea due to weakness of the airway walls and/or supporting cartilage, is a relatively common but frequently overlooked ..
- INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTIIDOUGLAS COLE; Fiscal Year: 2009..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
- INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTIIDOUGLAS COLE; Fiscal Year: 2007..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
- Bordetella pathogenesis: an undergraduate research toolLouise Temple; Fiscal Year: 2007..We have developed an explant culture system for ciliated cells from embryonic turkey trachea and purified cilia from adult turkey trachea...
- Coaxial Everting Membrane Catheter Bronchoalveolar LavagWilliam Krause; Fiscal Year: 2006..However, sputum (lung, trachea or oropharyngeal secretions) is often contaminated by saliva, oropharyngeal organisms and squamous cells that are ..
- Integration by Airway Parasympathic Ganglia NeuronsAllen Myers; Fiscal Year: 2004..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, ..
- Host-Pathogen Interactions in the Mammalian AirwayGill Diamond; Fiscal Year: 2006Epithelial cells lining the mammalian trachea form a crucial site in the host defense against airborne microbial pathogens, releasing numerous antimicrobial factors...
- Respiratory Mechanics in Lung Disease and SurgeryStephen Loring; Fiscal Year: 2004..3) To develop methods to measure the pressure-area characteristics of the trachea in patients undergoing bronchoscopy and to determine whether the site of expiratory flow limitation in these ..
- Mechanisms of anesthetic effects on tachykinin induced airway toneCharles Emala; Fiscal Year: 2007..Intubation of the trachea during induction or the presence of an endotracheal tube during emergence from anesthesia initiates a neurally-..
- Mechanisms of anesthetic effects on tachykinin induced airway toneCharles W Emala; Fiscal Year: 2010..Intubation of the trachea during induction or the presence of an endotracheal tube during emergence from anesthesia initiates a neurally-..
- GENE THERAPY IN MUCOPLYSACCHARIDOSIS VIIMark Haskins; Fiscal Year: 2006..VII, the dogs are growth-retarded, have a facial dysmorphia, corneal clouding, thickened heart valves, a narrow trachea, deformed sternum, and synovial joints with progressive degenerative lesions of the articular cartilage such that ..
- NEURAL REGULATION OF PANCREATIC FUNCTIONKimberly Kirkwood; Fiscal Year: 2002..The regulation of pancreatic inflammation is poorly understood. In the trachea, sensory nerves regulate inflammation by releasing tachykinins that bind to endothelial cells and induce ..
- 3-Dimensional modeling of basal cell function in pseudostratified epitheliaSylvie Breton; Fiscal Year: 2009..We will focus on two epithelia, the epididymis, which is at the core of our research program, and the trachea. The epididymis, which connects the testis to the vas deferens, is involved in the maturation and storage of ..
- 3-Dimensional modeling of basal cell function in pseudostratified epitheliaSylvie Breton; Fiscal Year: 2010..We will focus on two epithelia, the epididymis, which is at the core of our research program, and the trachea. The epididymis, which connects the testis to the vas deferens, is involved in the maturation and storage of ..