Genomes and Genes
Summary: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Publications243 found, 100 shown here
- Basal cells as stem cells of the mouse trachea and human airway epitheliumJason R Rock
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 106:12771-5. 2009The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14...
- A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferretsAkila Jayaraman
Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e17616. 2011..These findings are significant in the context of monitoring the evolution of the currently circulating 2009 H1N1 viruses...
- A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal systemAmin S Ghabrial
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
PLoS Genet 7:e1002087. 2011....
- Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?Luke J Janssen
Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002..Also, we will examine some novel ionic mechanisms in the context of Ca(2+) handling and excitation-contraction coupling in ASM...
- Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutantsC Mendelsohn
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
Development 120:2749-71. 1994..We discuss several possibilities that may account for the apparent functional redundancy observed amongst retinoic acid receptors during embryogenesis...
- Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathwayPatrick Laprise
Laval University Cancer Research Center, CRCHUQ Hôtel Dieu de Québec, 9 McMahon, Quebec, QC G1R 2J6, Canada
Curr Biol 20:55-61. 2010..However, the mechanisms of tube size control remain poorly understood. In the Drosophila trachea, tube dimensions are regulated by a luminal extracellular matrix (ECM)...
- Sonic hedgehog regulates branching morphogenesis in the mammalian lungC V Pepicelli
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Biol 8:1083-6. 1998..In Shh null mutants, we found that the trachea and esophagus do not separate properly and the lungs form a rudimentary sac due to failure of branching and ..
- Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative populationYingjian You
Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Am J Physiol Lung Cell Mol Physiol 283:L1315-21. 2002..This approach provides a high-fidelity in vitro model for evaluation of gene regulation and expression in mouse airway epithelial cells...
- H5N1 Virus Attachment to Lower Respiratory TractDebby van Riel
Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
Science 312:399. 2006..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
- Cholinergic chemosensory cells in the trachea regulate breathingGabriela Krasteva
Institute of Anatomy and Cell Biology and Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen D 35385, Germany
Proc Natl Acad Sci U S A 108:9478-83. 2011..Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (α-gustducin, phospholipase C(β2)..
- Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndromeCaterina Tiozzo
Department of Pediatrics, Women s and Children s Hospital, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Pediatr Res 66:386-90. 2009..which is a disease characterized by a uniform cartilaginous sleeve in place of a normally ribbed cartilagenous trachea. We have studied the cellular and molecular basis of this phenotype in a mouse model of AS (Fgfr2c(+/Delta) mice),..
- Tracheal dimensions in human fetuses: an anatomical, digital and statistical studyMichał Szpinda
Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum, Karłowicza 24 Street, 85 092 Bydgoszcz, Poland
Surg Radiol Anat 34:317-23. 2012..The present study was performed to compile normative data for external dimensions of the trachea at varying gestational age.
- Anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles in fetuses measured ex vivo- Harjeet
Department of Anatomy Postgraduate Institute of Medical Education and Research, Chandigarh, India
Paediatr Anaesth 18:1029-34. 2008..This study is aimed to determine the anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles and their correlation to age and crown rump length (CRL) in fetuses...
- Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesiaAnu Sironen
Biotechnology and Food Research, Animal Genomics, MTT Agrifood Research Finland, Jokioinen, Finland
Biol Reprod 85:690-701. 2011..Taken together, the data in this study demonstrate that SPEF2 is required for cilia function and identify a new genetic cause of PCD in mice...
- Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse tracheaRainer Schreiber
Institut fur Physiologie, Universitat Regensburg, Germany
Cell Physiol Biochem 16:99-108. 2005..Here we show that these metabolites change electrolyte transport by stimulation of P2Y6 receptors in mouse trachea. Immunohistochemistry confirmed luminal and basolateral expression of P2Y6 receptors...
- Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigsNam Soo Joo
Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
J Clin Invest 120:3161-6. 2010..These data are a step toward determining whether gland secretory defects contribute to CF airway disease...
- The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epitheliumEmma L Rawlins
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Cell Stem Cell 4:525-34. 2009..In the trachea, Clara cells give rise to ciliated cells but do not self-renew extensively...
- In vivo coupling of cell elongation and lumen formation in a single cellLouis Gervais
Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
Curr Biol 20:359-66. 2010..We addressed this issue by examining intracellular lumen formation in the Drosophila trachea. The main branches of the Drosophila tracheal system have an extracellular lumen because their cells fold to form ..
- Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryosP Minoo
Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
Dev Biol 209:60-71. 1999..Failure in septation between the trachea and the esophagus in Nkx2...
- Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cellsZheng Xing
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA
Am J Respir Cell Mol Biol 44:24-33. 2011..The findings in this study will further our understanding of host defense mechanisms and the pathogenesis of H9N2 influenza viruses in human respiratory epithelium...
- In vivo and in vitro morphometry of the human tracheaKirollos Salah Kamel
Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
Clin Anat 22:571-9. 2009Most morphometric studies of the human trachea have relied on plain radiographs with their attendant limitations. Reports using computed tomography (CT) have focused on the growing trachea or one particular dimension...
- Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2Eric T Domyan
Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
Development 138:971-81. 2011The mammalian foregut gives rise to the dorsally located esophagus and stomach and the ventrally located trachea and lung...
- Tube continued: morphogenesis of the Drosophila tracheal systemJodi Schottenfeld
Department of Cell and Developmental Biology, 1214 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
Curr Opin Cell Biol 22:633-9. 2010....
- Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defectsJ Aubin
Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Canada
Dev Biol 192:432-45. 1997..Since expression of Hoxa-5 is confined to the mesenchymal component of the developing trachea and lung, the effects observed in epithelial cells may result from a disruption of normal epithelial-mesenchymal ..
- Early restriction of peripheral and proximal cell lineages during formation of the lungAnne Karina T Perl
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
Proc Natl Acad Sci U S A 99:10482-7. 2002..Extensive or complete labeling of peripheral lung, thyroid, and thymic epithelia, but not trachea, bronchi, or gastrointestinal tract occurred when mice were exposed to doxycycline from embryonic day (E) 4...
- Ultrasound-guided percutaneous dilatational tracheostomy: a safe method to avoid cranial misplacement of the tracheostomy tubeA Sustic
Department of Anaesthesiology and ICU, University Hospital Rijeka, Croatia
Intensive Care Med 26:1379-81. 2000..05) and four (36%) patients had a broken tracheal ring (P = NS). The authors maintain that by using ultrasound-guided PDT cranial misplacement of the tracheostomy tube may be entirely avoided...
- The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extensionL Glazer
Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
Genes Dev 5:697-705. 1991..However, the extension of tracheal cell processes leading to the formation of the elaborate tree structure is blocked. The DFGF-R protein may thus participate in receiving spatial cues that guide tracheal cell outgrowth...
- Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxationGeorge Gallos
Dept of Anesthesiology, College of Physicians and Surgeons of Columbia Univ, 650 W 168 St, P and S Box 46, New York, NY, USA
Am J Physiol Lung Cell Mol Physiol 295:L1040-7. 2008....
- Four chamber view plus three-vessel and trachea view for a complete evaluation of the fetal heart during the second trimesterAntongiulio Del Bianco
Dipartimento Materno Infantile, Unità Operativa di Ostetricia e Ginecologia 2, Policlinico Univesitario, Foggia, Italy
J Perinat Med 34:309-12. 2006To test the efficacy of a recently introduced ultrasonic scanning plane (three vessel and trachea view -3VTV- plus color flow mapping -3VTVC) on a low-risk population for detection of congenital heart disease (CHD).
- Clinical transplantation of a tissue-engineered airwayPaolo Macchiarini
Department of General Thoracic Surgery, Hospital Clinic, Barcelona, Spain
Lancet 372:2023-30. 2008..We aimed to bioengineer tubular tracheal matrices, using a tissue-engineering protocol, and to assess the application of this technology in a patient with end-stage airway disease...
- Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptorsY Wang
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
Mol Pharmacol 60:1201-9. 2001..situ hybridization experiments detected alpha7 subunit mRNA in cultured human BEC and AEC and in sections of rat trachea. The binding of radiolabeled alpha-bungarotoxin revealed a few thousand binding sites per cell in cultured human ..
- Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapySundeep G Keswani
The Center for Molecular Fetal Therapy, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Pediatr Surg 46:33-8. 2011Our previous work in a human-fetal trachea xenograft model suggests potential benefits of treating cystic fibrosis in utero. The target for postnatal gene therapy in cystic fibrosis is tracheal submucosal glands (SMGs)...
- Human and avian influenza viruses target different cell types in cultures of human airway epitheliumMikhail N Matrosovich
Institute of Virology, Philipps University, 35037 Marburg, Germany
Proc Natl Acad Sci U S A 101:4620-4. 2004..Our data throw light on the mechanisms of generation of pandemic viruses from their avian progenitors and open avenues for cell level-oriented studies on the replication and pathogenicity of influenza virus in humans...
- KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channelsBin Nan Wu
Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Br J Pharmacol 142:1105-14. 2004..KMUP-1 (0.01-100 microm) induced concentration-dependent relaxation responses in guinea-pig epithelium-intact trachea precontracted with carbachol...
- Prenatal and early postnatal morphogenesis and growth of human laryngotracheal structuresPierre Fayoux
Department of Otolaryngology Head and Neck Surgery, University Hospital of Lille, France
J Anat 213:86-92. 2008..An anatomical prospective study was based on examination of larynx and trachea from 300 routine autopsies of fetuses and infants, free of malformation and never intubated...
- Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated tracheaPeter J Henry
School of Medicine and Pharmacology, University of Western Australia, Nedlands
J Pharmacol Exp Ther 314:995-1001. 2005..capacity of SLIGRL to elevate PGE(2) levels and produce relaxation in isolated segments of upper and lower mouse trachea. SLIGRL produced concentration-dependent increases in PGE(2) levels and smooth muscle relaxation, although both ..
- Late complications of tracheostomyScott K Epstein
Department of Medicine, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston MA 02135, USA
Respir Care 50:542-9. 2005..For the most frequent complication, tracheal stenosis, a multidisciplinary approach utilizing bronchoscopy, laser, airway stents, and tracheal surgery is most effective...
- Pathogenicity of a QX strain of infectious bronchitis virus in specific pathogen free and commercial broiler chickens, and evaluation of protection induced by a vaccination programme based on the Ma5 and 4/91 serotypesCalogero Terregino
OIE FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell Universita 10, Legnaro PD, Italy
Avian Pathol 37:487-93. 2008..This study confirms that vaccination at 1 day old and at 14 days of age using the Ma5 and 4/91 IB vaccines may be instrumental in reducing the economic impact of QX IB virus infections in layer and broiler farms...
- beta-Catenin promotes respiratory progenitor identity in mouse foregutKelley S Harris-Johnson
Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 106:16287-92. 2009The mammalian respiratory system, consisting of both trachea and lung, initiates from the foregut endoderm. The molecular program that instructs endodermal cells to adopt the respiratory fate is not fully understood...
- Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated tracheaAgung Endro Nugroho
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia
Pak J Pharm Sci 24:427-33. 2011..In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80...
- New quantitative patterns of the growing trachea in human fetusesMichał Szpinda
Department of Normal Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland
Med Sci Monit 18:PH63-70. 2012..Rapid progress in perinatal medicine has resulted in numerous tracheo-bronchial interventions on fetal and neonatal airways. The present study was performed to compile normative data for tracheal dimensions at varying gestational ages...
- Tracheal agenesis with unique anatomyNia Fraser
Department of Paediatric Surgery, Nottingham Hospitals NHS Trust, Queens Medical Centre, NG7 2UH Nottingham, UK
J Pediatr Surg 40:e7-10. 2005..The possibility of surgical correction rests on early diagnosis, anatomy, birth weight, and associated anomalies. Early recognition is mandatory, but in our case, the low birth weight precluded consideration for reconstructive surgery...
- Percutaneous fetal endoscopic tracheal occlusion (FETO) for severe left-sided congenital diaphragmatic herniaJ Jani
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
Clin Obstet Gynecol 48:910-22. 2005
- Determination of endotracheal tube size in a perinatal population: an anatomical and experimental studyPierre Fayoux
Service d Oto Rhino Laryngologie ORL et Chirurgie CervicoFaciale Hôpital Huriez, Centre Hospitalier Regional Universitaire CHRU Lille, France
Anesthesiology 104:954-60. 2006This study aimed at correlating anatomical dimensions of the larynx and trachea to age and weight in a prenatal population. Endotracheal tube size determination was then proposed according to these considerations.
- The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size controlKevin S Nelson
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Genetics 185:831-9. 2010..Double- and triple-mutant combinations of Sinuous and Megatrachea with Kune-kune resemble the Kune-kune single mutant, suggesting that Kune-kune has a more central role in septate junction formation than either Sinuous or Megatrachea...
- Real-time ultrasound-guided percutaneous dilatational tracheostomy: a feasibility studyVenkatakrishna Rajajee
Department of Neurosurgery and Neurology, University of Michigan Health System, 3552 Taubman Health Care Center, 1500 E, Medical Center Dr, SPC 5338, Ann Arbor, MI 48109 5338, USA
Crit Care 15:R67. 2011..Our objective was to demonstrate that PT performed under real-time US guidance with visualization of needle path during tracheal puncture is feasible, including in patients with features that increase the technical difficulty of PT...
- Telocytes in trachea and lungsY Zheng
Department of Pulmonary Medicine and Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China
J Cell Mol Med 15:2262-8. 2011We show the existence of a novel type of interstitial cell-telocytes (TC) in mouse trachea and lungs...
- Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approachYing Wang
Department of Poultry Science, Texas A and M University College Station, TX 77843 2472, USA
BMC Genomics 10:512. 2009..Avian influenza virus (AIV) not only causes significant economic losses in poultry production, but also is of great concern to human health. The objective of this study was to identify miRNAs associated with AIV infections in chickens...
- Tracheal Basal cells: a facultative progenitor cell poolBrook B Cole
Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, Colorado, USA
Am J Pathol 177:362-76. 2010..In this study, we used gene expression and histomorphometric analysis of the steady-state and naphthalene-injured trachea to evaluate the predictions of this model...
- Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathwaysOfir Bachar
Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
Eur J Immunol 34:1196-207. 2004..Costimulation of these receptors results in NF-kappa B- and JNK-mediated transcription of B(1) and B(2) receptor, inducing hyper-responsiveness to bradykinin...
- The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cellsIan Sayers
Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
Eur J Pharmacol 531:9-12. 2006..05). Therefore, beta2-adrenoceptor agonists can augment spasmogen responses in airway smooth muscle but not via a G-protein/PLC-beta1 mediated mechanism...
- A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit tracheaK Iizuka
First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
Br J Pharmacol 128:925-33. 1999..5'-O-(3-thiotriphosphate) (GTPgammaS)-induced contraction in alpha-toxin- or beta-escin-permeabilized rabbit trachea. 2 Although pre-treatment with Y-27632 dose-dependently inhibited GTPgammaS (10 microM)-induced Ca2+ ..
- Morphogenesis of the trachea and esophagus: current players and new roles for noggin and BmpsJianwen Que
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Differentiation 74:422-37. 2006..endoderm, the folding of the endoderm into a foregut tube, and the subsequent separation of the foregut tube into trachea and esophagus...
- A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila tracheaMonn Monn Myat
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Dev Biol 281:38-52. 2005..These studies support a model in which both the Dpp- and the FGF-signaling pathways control expression of knirps and knirps-related, thereby regulating cell migration during dorsal branch formation...
- Lung epithelial cells release ATP during ozone exposure: signaling for cell survivalShama Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 39:213-26. 2005..Thus, extracellularly released ATP signals to prevent ozone-induced death and supplementation with ATP or its analogs can augment protection, at least in part via Akt and /or ERK signaling pathways and their metabolic effects...
- Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell deathKatrin Anne Becker
Dept of Molecular Biology, University of Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Biochem Biophys Res Commun 403:368-74. 2010..In this study we investigated whether ceramide concentrations are also altered in the trachea and the intestine of cystic fibrosis mice and whether an accumulation of ceramide in these organs has functional ..
- cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airwaysRobert J Lee
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6085, USA
J Clin Invest 120:3137-48. 2010..These results identify important molecular mechanisms of cAMP-dependent secretion, including a requirement for Ca2+ signaling, and suggest new therapeutic approaches to correct defective submucosal gland secretion in CF...
- Analysis of component findings in 79 patients diagnosed with VACTERL associationBenjamin D Solomon
Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Am J Med Genet A 152:2236-44. 2010..These findings have implications for both our understanding of VACTERL association and for the approach to research involving this condition...
- Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in DrosophilaDominique Förster
Institute of Zoology, Universitat Zurich, CH 8057 Zurich, Switzerland
Curr Biol 20:62-8. 2010..These results indicate a critical role of membrane-associated proteins in the process and imply a mechanism that coordinates autonomous behaviors of individual cells within epithelial structures...
- The replicase gene of avian coronavirus infectious bronchitis virus is a determinant of pathogenicityMaria Armesto
Division of Microbiology, Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire, United Kingdom
PLoS ONE 4:e7384. 2009....
- Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epitheliumPhilip Thai
Center for Comparative Respiratory Biology and Medicine, Surge 1, Room 1121, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
Am J Respir Cell Mol Biol 33:523-30. 2005..Thus, these results suggest that the two biomakers of the metaplastic airway mucous cell type are differentially regulated by JAK/STAT6-dependent and -independent pathways...
- IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscleOmar Tliba
Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Br J Pharmacol 140:1159-62. 2003..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
- Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cellsAida Ibricevic
Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
J Virol 80:7469-80. 2006....
- Hyperoxia impairs airway relaxation in immature rats via a cAMP-mediated mechanismMaroun J Mhanna
Department of Pediatrics, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH 44109, USA
J Appl Physiol (1985) 96:1854-60. 2004..EFS-induced relaxation of preconstricted trachea was diminished in hyperoxic vs. normoxic animals (P < 0.05)...
- Regulation of early lung morphogenesis: questions, facts and controversiesWellington V Cardoso
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
Development 133:1611-24. 2006..Here, we review early stages in lung development and highlight questions and controversies regarding their molecular regulation...
- Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epitheliumMitsuko Kondo
First Department of Medicine, Tokyo Women s Medical University, School of Medicine, Japan
Am J Respir Cell Mol Biol 27:536-41. 2002..In this study, primary epithelial cells from guinea pig trachea were cultured at an air-liquid interface, and immediately after achieving confluence at Day 7 they were treated ..
- Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxiaNathan T Mortimer
Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Dev Biol 329:294-305. 2009..The identification of an early stage of tracheal development that is vulnerable to hypoxia is an important addition to models of the invertebrate hypoxic response...
- Tracheal occlusion stimulates cell cycle progression and type I cell differentiation in lungs of fetal ratsJyoji Yoshizawa
Department of Veteran Affairs, University of California, San Francisco, CA 94118, USA
Am J Physiol Lung Cell Mol Physiol 285:L344-53. 2003..We examined effects of a novel method of TO (unipolar microcautery to seal the trachea) produced at 19.5-20 days (d) of gestation in fetal rats; fetuses were delivered at term, 22 d...
- IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscleM M Grunstein
Division of Pulmonary Medicine, Joseph Stokes, Jr Research Institute, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Physiol Lung Cell Mol Physiol 282:L520-8. 2002....
- sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airwaysN Hacohen
Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
Cell 92:253-63. 1998..sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development...
- Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A virusesAravind Srinivasan
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:2800-5. 2008..In summary, this study establishes a quantitative biochemical correlate for influenza A virus transmission...
- Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1)D Duan
Department of Anatomy and Cell Biology and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA
Development 126:4441-53. 1999..is upregulated in submucosal gland progenitor cells just prior to gland bud formation in the developing ferret trachea. In the current report, several animal models were utilized to functionally investigate the role of LEF1 in ..
- A method of endotracheal intubation and pulmonary functional assessment for repeated studies in miceR H Brown
Department of Anesthesiology, Environmental Health Sciences Division of Physiology, and Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Appl Physiol (1985) 87:2362-5. 1999The ability to successfully intubate the trachea of mice and control their ventilation is important for longitudinal studies requiring recovery from anesthesia and repeated pulmonary function measurements or other evaluations, such as ..
- EGF signalling regulates cell invagination as well as cell migration during formation of tracheal system in DrosophilaM Llimargas
Centre d Investigació i Desenvolupament CSIC, C Jordi Girona 18 26, E 08034 Barcelona, Spain
Dev Genes Evol 209:174-9. 1999..We discuss how the consecutive steps of tracheal morphogenesis might affect the final branching pattern...
- A novel murine beta -defensin expressed in tongue, esophagus, and tracheaH P Jia
Departments of Pediatrics, Genetics Ph D Program, and Microbiology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 275:33314-20. 2000..The peptide shares approximately 40% identity with HBD-2. MBD-4 mRNA was expressed in the esophagus, tongue, and trachea but not in any of 20 other tissues surveyed...
- A mathematical model of airway and pulmonary arteriole smooth muscleInga Wang
Department of Mathematics, University of Auckland, Auckland, New Zealand
Biophys J 94:2053-64. 2008..In addition, the model also predicts that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration...
- boudin is required for septate junction organisation in Drosophila and codes for a diffusible protein of the Ly6 superfamilyAssia Hijazi
Université de Toulouse UPS, Centre de Biologie du Developpement, CNRS UMR 5547, Bâtiment 4R3, 118 route de Narbonne, F 31062 Toulouse, France
Development 136:2199-209. 2009..Our work opens the way for future studies addressing the function of Ly6 proteins using Drosophila as a model system...
- Tracheal agenesis revisited: analysis of associated anomaliesJ A Evans
Department of Human Genetics, University of Manitoba and Children s Hospital, Winnipeg, Canada
Am J Med Genet 82:415-22. 1999..Anomalies in the first group were primarily restricted to the trachea, larynx, and cardiovascular system...
- Where's the tube? Evaluation of hand-held ultrasound in confirming endotracheal tube placementRosaleen Chun
Department of Anesthesia, Foothills Medical Centre, Calgary, Alberta, Canada
Prehosp Disaster Med 19:366-9. 2004..Thoracic sonography, previously utilized to detect pneumothoraces, has not been tested to assess ETT placement...
- A composite tissue-engineered trachea using sheep nasal chondrocyte and epithelial cellsKoji Kojima
Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, Massachusetts, USA
FASEB J 17:823-8. 2003..Implants were harvested 4 wk later and analyzed. The morphology of implants resembles that of native sheep trachea. H&E staining shows the presence of mature cartilage and formation of a pseudo-stratified columnar epithelium,..
- Tubulogenesis: an inside jobLianna E Swanson
Northwestern University, Evanston, Illinois 60208 3500, USA
Curr Biol 16:R51-3. 2006
- The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine tracheaF Grahammer
Institute of Physiology, Albert Ludwigs Universitat, Hermann Herder Strabetae 7, D 79104 Freiburg, Germany
J Biol Chem 276:42268-75. 2001..As described for colonic epithelium, the current through KCNQ1 complexes in murine trachea is specifically inhibited by the chromanol 293B...
- Differentiated cultures of primary hamster tracheal airway epithelial cellsRegina K Rowe
Molecular Microbiology and Microbial Pathogenesis Graduate Program, Washington University School of Medicine, St Louis, Missouri 63110, USA
In Vitro Cell Dev Biol Anim 40:303-11. 2004....
- A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cellsCharlotte K Billington
Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK
Am J Respir Cell Mol Biol 38:1-7. 2008..These data suggest that PDE4D5, despite being a minor component of the tissue PDE pool, is the key physiological regulator of beta(2)AR-induced cAMP turnover within human airway smooth muscle...
- A simple method to predict pretracheal tissue thickness to prevent accidental decannulation in the obeseChristopher Szeto
Department of Otolaryngology Head and Neck Surgery, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Otolaryngol Head Neck Surg 143:223-9. 2010..Our purpose was to 1) establish the range of trachea-to-skin soft tissue thickness (TTSSTT) in obese patients and 2) determine which easily obtained anthropometric ..
- Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of beta(2)-adrenoceptorsYoshio Tanaka
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Science, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
J Smooth Muscle Res 41:153-61. 2005..adrenaline-induced relaxation was pharmacologically identified in smooth muscle cells of the isolated guinea-pig trachea. Adrenaline produced a concentration-dependent relaxation with a pD(2) value of 7.1...
- Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitorsJenny Hallgren
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:20478-83. 2007..Thus, these studies demonstrate a role for a chemokine receptor in regulating endothelial VCAM-1 expression, MCp migration, and the level of intraepithelial MC in the lung of aerosolized, antigen-challenged mice...
- Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivoHeather MacPherson
MRC Human Genetics Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK
J Cell Sci 118:2441-50. 2005..that mice engrafted with side population cells have donor-derived cells present in the epithelial lining of the trachea following damage and repair. Donor-derived cells were found at a frequency of 0.83%...
- Analysis of FOXF1 and the FOX gene cluster in patients with VACTERL associationNneamaka B Agochukwu
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 35, Room 1B207, 35 Convent Drive MSC 3717, Bethesda, MD 20892 3717, United States
Eur J Med Genet 54:323-8. 2011....
- Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glandsMonal Khansaheb
Cystic Fibrosis Research Laboratory, Stanford Univ, CA 94305 2130, USA
Am J Physiol Lung Cell Mol Physiol 300:L370-9. 2011..These and prior results suggest that SubP stimulates pig gland secretion via CFTR- and Ca(2+)-activated Cl(-) channels...
- Ultrasound-guided percutaneous dilatational tracheostomy with laryngeal mask airway control in a morbidly obese patientAlan Sustic
Department of Anesthesiology and ICU, University Hospital Rijeka, Rijeka, Croatia
J Clin Anesth 16:121-3. 2004..Possible advantages of an ultrasonography-guided method and LMA control in morbidly obese patients also are discussed...
- Anatomical variation in the position of the brachiocephalic trunk (innominate artery) with respect to the trachea: a computed tomography-based study and literature review of Innominate Artery Compression SyndromeS L Fawcett
Department of Radiology, Cambridge University Teaching Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
Clin Anat 23:61-9. 2010..has been controversially attributed to an anomalous origin of this vessel to the left of, and hence crossing, the trachea. The aim of this study was to establish the normal relationship between the BT and trachea in infants, children, ..
- Post-intubation tracheal injury: report of three cases and literature reviewCarlos Remolina Medina
Pavilhão Pereira Filho, Complexo Hospitalar Santa Casa, Porto Alegre, RS, Brasil
J Bras Pneumol 35:809-13. 2009..We report the cases of three patients presenting tracheal laceration due to traumatic orotracheal intubation, two submitted to surgical treatment and one submitted to conservative treatment...
- Anatomy of the trachea, carina, and bronchiDouglas J Minnich
Division of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Blake 1570, Boston, MA 02114, USA
Thorac Surg Clin 17:571-85. 2007..In addition, the more precise delineation of tracheal anatomy has contributed largely to the advancement of airway surgery in recent years. This article serves as a foundation for learning or reviewing this important topic...
- The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearanceN Wienkötter
Department of Pharmacology, Institute of Medicinal Chemistry, Munster, Germany
Planta Med 74:105-8. 2008NIGELLA SATIVA L. has many effects including those on the gastrointestinal tract and trachea and is, therefore, used in the Mediteranean area and in India/Pakistan...
- 5q11.2 deletion in a patient with tracheal agenesisElisabeth M de Jong
Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
Eur J Hum Genet 18:1265-8. 2010..No common deletions or duplications are found in our cohort, suggesting that TA is a genetically heterogeneous disorder...
- The gross anatomy of larynx, trachea and syrinx in the long-legged buzzard (Buteo rufinus)M Kabak
Department of Anatomy, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Kurupelit Samsun, Turkey
Anat Histol Embryol 36:27-32. 2007..The partially ossified corpus and ala of the cricoid cartilage were connected with cartilaginous plate. Trachea was formed up of complete cartilage circles...
- Nontraumatic disruption of the fibrocartilaginous trachea: causes and clinical outcomesMichelle R Aerni
Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
Chest 130:1143-9. 2006Nontraumatic disruption of the fibrocartilaginous trachea is rare, and the appropriate management of this condition is not well-characterized.
- Agreement between quantitative cultures of postintubation tracheal aspiration and plugged telescoping catheter, protected specimen brush, or BAL for the diagnosis of nosocomial pneumoniaChristophe Clec'h
Service de Reanimation, Hopital Avicenne, 125, route de Stalingrad, 93009 Bobigny Cedex, France
Chest 130:956-61. 2006..Our aim was to compare the diagnostic accuracy of PITA to that of PSB, BAL, or PTC in patients requiring MV for suspected NP...
- Role of potassium channels in the relaxant effect of levosimendan in guinea pig tracheal preparationsBilsen Eksert
Department of Pharmacology, Akdeniz University, Medical Faculty, Antalya, Turkey
Pharmacol Rep 61:275-80. 2009..The present findings suggested that the relaxant effect induced by levosimendan might be partially due to K(ATP) and BK Ca in isolated guinea pig tracheal rings...
- Ultrasound-guided localisation of the tracheaJ A Orr
Anaesthesia 62:972-3. 2007
- Nasal dosimetry of diacetyl and butyric acid vaporsJohn Morris; Fiscal Year: 2005..to diacetyl (2,3 butadiene), a major component of butter flavoring vapors, results in necrosis of the nasal and trachea, but not the intrapulmonary airways...
- Neuromuscular blocker-induced asthma during anesthesiaCharles Emala; Fiscal Year: 2006..During intubation of the trachea, parasympathetic nerves release acetylcholine that act on M3 muscarinic receptors on airway smooth muscle to ..
- CT Diagnosis of Tracheomalacia in Patients with COPDPhillip Boiselle; Fiscal Year: 2009..Acquired tracheomalacia, a condition defined by excessive expiratory collapse of the trachea due to weakness of the airway walls and/or supporting cartilage, is a relatively common but frequently overlooked ..
- INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTIIDOUGLAS COLE; Fiscal Year: 2009..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
- INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTIIDOUGLAS COLE; Fiscal Year: 2007..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
- Bordetella pathogenesis: an undergraduate research toolLouise Temple; Fiscal Year: 2007..We have developed an explant culture system for ciliated cells from embryonic turkey trachea and purified cilia from adult turkey trachea...
- Coaxial Everting Membrane Catheter Bronchoalveolar LavagWilliam Krause; Fiscal Year: 2006..However, sputum (lung, trachea or oropharyngeal secretions) is often contaminated by saliva, oropharyngeal organisms and squamous cells that are ..
- Integration by Airway Parasympathic Ganglia NeuronsAllen Myers; Fiscal Year: 2004..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, ..
- Host-Pathogen Interactions in the Mammalian AirwayGill Diamond; Fiscal Year: 2006Epithelial cells lining the mammalian trachea form a crucial site in the host defense against airborne microbial pathogens, releasing numerous antimicrobial factors...
- Respiratory Mechanics in Lung Disease and SurgeryStephen Loring; Fiscal Year: 2004..3) To develop methods to measure the pressure-area characteristics of the trachea in patients undergoing bronchoscopy and to determine whether the site of expiratory flow limitation in these ..
- Mechanisms of anesthetic effects on tachykinin induced airway toneCharles Emala; Fiscal Year: 2007..Intubation of the trachea during induction or the presence of an endotracheal tube during emergence from anesthesia initiates a neurally-..
- Mechanisms of anesthetic effects on tachykinin induced airway toneCharles W Emala; Fiscal Year: 2010..Intubation of the trachea during induction or the presence of an endotracheal tube during emergence from anesthesia initiates a neurally-..
- GENE THERAPY IN MUCOPLYSACCHARIDOSIS VIIMark Haskins; Fiscal Year: 2006..VII, the dogs are growth-retarded, have a facial dysmorphia, corneal clouding, thickened heart valves, a narrow trachea, deformed sternum, and synovial joints with progressive degenerative lesions of the articular cartilage such that ..
- NEURAL REGULATION OF PANCREATIC FUNCTIONKimberly Kirkwood; Fiscal Year: 2002..The regulation of pancreatic inflammation is poorly understood. In the trachea, sensory nerves regulate inflammation by releasing tachykinins that bind to endothelial cells and induce ..
- 3-Dimensional modeling of basal cell function in pseudostratified epitheliaSylvie Breton; Fiscal Year: 2009..We will focus on two epithelia, the epididymis, which is at the core of our research program, and the trachea. The epididymis, which connects the testis to the vas deferens, is involved in the maturation and storage of ..
- 3-Dimensional modeling of basal cell function in pseudostratified epitheliaSylvie Breton; Fiscal Year: 2010..We will focus on two epithelia, the epididymis, which is at the core of our research program, and the trachea. The epididymis, which connects the testis to the vas deferens, is involved in the maturation and storage of ..