trachea

Summary

Summary: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

Top Publications

  1. pmc Basal cells as stem cells of the mouse trachea and human airway epithelium
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:12771-5. 2009
  2. pmc A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets
    Akila Jayaraman
    Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17616. 2011
  3. pmc A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system
    Amin S Ghabrial
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    PLoS Genet 7:e1002087. 2011
  4. ncbi Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?
    Luke J Janssen
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002
  5. ncbi Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 120:2749-71. 1994
  6. pmc Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway
    Patrick Laprise
    Laval University Cancer Research Center, CRCHUQ Hôtel Dieu de Québec, 9 McMahon, Quebec, QC G1R 2J6, Canada
    Curr Biol 20:55-61. 2010
  7. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
  8. ncbi Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population
    Yingjian You
    Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1315-21. 2002
  9. ncbi H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
  10. pmc Cholinergic chemosensory cells in the trachea regulate breathing
    Gabriela Krasteva
    Institute of Anatomy and Cell Biology and Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen D 35385, Germany
    Proc Natl Acad Sci U S A 108:9478-83. 2011

Detail Information

Publications243 found, 100 shown here

  1. pmc Basal cells as stem cells of the mouse trachea and human airway epithelium
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:12771-5. 2009
    The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14...
  2. pmc A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets
    Akila Jayaraman
    Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17616. 2011
    ..These findings are significant in the context of monitoring the evolution of the currently circulating 2009 H1N1 viruses...
  3. pmc A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system
    Amin S Ghabrial
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    PLoS Genet 7:e1002087. 2011
    ....
  4. ncbi Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?
    Luke J Janssen
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002
    ..Also, we will examine some novel ionic mechanisms in the context of Ca(2+) handling and excitation-contraction coupling in ASM...
  5. ncbi Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 120:2749-71. 1994
    ..We discuss several possibilities that may account for the apparent functional redundancy observed amongst retinoic acid receptors during embryogenesis...
  6. pmc Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway
    Patrick Laprise
    Laval University Cancer Research Center, CRCHUQ Hôtel Dieu de Québec, 9 McMahon, Quebec, QC G1R 2J6, Canada
    Curr Biol 20:55-61. 2010
    ..However, the mechanisms of tube size control remain poorly understood. In the Drosophila trachea, tube dimensions are regulated by a luminal extracellular matrix (ECM)...
  7. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In Shh null mutants, we found that the trachea and esophagus do not separate properly and the lungs form a rudimentary sac due to failure of branching and ..
  8. ncbi Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population
    Yingjian You
    Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1315-21. 2002
    ..This approach provides a high-fidelity in vitro model for evaluation of gene regulation and expression in mouse airway epithelial cells...
  9. ncbi H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
    ..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
  10. pmc Cholinergic chemosensory cells in the trachea regulate breathing
    Gabriela Krasteva
    Institute of Anatomy and Cell Biology and Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen D 35385, Germany
    Proc Natl Acad Sci U S A 108:9478-83. 2011
    ..Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (α-gustducin, phospholipase C(β2)..
  11. pmc Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome
    Caterina Tiozzo
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Pediatr Res 66:386-90. 2009
    ..which is a disease characterized by a uniform cartilaginous sleeve in place of a normally ribbed cartilagenous trachea. We have studied the cellular and molecular basis of this phenotype in a mouse model of AS (Fgfr2c(+/Delta) mice),..
  12. pmc Tracheal dimensions in human fetuses: an anatomical, digital and statistical study
    Michał Szpinda
    Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum, Karłowicza 24 Street, 85 092 Bydgoszcz, Poland
    Surg Radiol Anat 34:317-23. 2012
    ..The present study was performed to compile normative data for external dimensions of the trachea at varying gestational age.
  13. ncbi Anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles in fetuses measured ex vivo
    - Harjeet
    Department of Anatomy Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Paediatr Anaesth 18:1029-34. 2008
    ..This study is aimed to determine the anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles and their correlation to age and crown rump length (CRL) in fetuses...
  14. pmc Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia
    Anu Sironen
    Biotechnology and Food Research, Animal Genomics, MTT Agrifood Research Finland, Jokioinen, Finland
    Biol Reprod 85:690-701. 2011
    ..Taken together, the data in this study demonstrate that SPEF2 is required for cilia function and identify a new genetic cause of PCD in mice...
  15. ncbi Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea
    Rainer Schreiber
    Institut fur Physiologie, Universitat Regensburg, Germany
    Cell Physiol Biochem 16:99-108. 2005
    ..Here we show that these metabolites change electrolyte transport by stimulation of P2Y6 receptors in mouse trachea. Immunohistochemistry confirmed luminal and basolateral expression of P2Y6 receptors...
  16. pmc Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs
    Nam Soo Joo
    Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
    J Clin Invest 120:3161-6. 2010
    ..These data are a step toward determining whether gland secretory defects contribute to CF airway disease...
  17. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    ..In the trachea, Clara cells give rise to ciliated cells but do not self-renew extensively...
  18. doi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..We addressed this issue by examining intracellular lumen formation in the Drosophila trachea. The main branches of the Drosophila tracheal system have an extracellular lumen because their cells fold to form ..
  19. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..Failure in septation between the trachea and the esophagus in Nkx2...
  20. pmc Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells
    Zheng Xing
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA
    Am J Respir Cell Mol Biol 44:24-33. 2011
    ..The findings in this study will further our understanding of host defense mechanisms and the pathogenesis of H9N2 influenza viruses in human respiratory epithelium...
  21. ncbi In vivo and in vitro morphometry of the human trachea
    Kirollos Salah Kamel
    Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Clin Anat 22:571-9. 2009
    Most morphometric studies of the human trachea have relied on plain radiographs with their attendant limitations. Reports using computed tomography (CT) have focused on the growing trachea or one particular dimension...
  22. pmc Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    Eric T Domyan
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 138:971-81. 2011
    The mammalian foregut gives rise to the dorsally located esophagus and stomach and the ventrally located trachea and lung...
  23. pmc Tube continued: morphogenesis of the Drosophila tracheal system
    Jodi Schottenfeld
    Department of Cell and Developmental Biology, 1214 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 22:633-9. 2010
    ....
  24. ncbi Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects
    J Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Canada
    Dev Biol 192:432-45. 1997
    ..Since expression of Hoxa-5 is confined to the mesenchymal component of the developing trachea and lung, the effects observed in epithelial cells may result from a disruption of normal epithelial-mesenchymal ..
  25. pmc Early restriction of peripheral and proximal cell lineages during formation of the lung
    Anne Karina T Perl
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 99:10482-7. 2002
    ..Extensive or complete labeling of peripheral lung, thyroid, and thymic epithelia, but not trachea, bronchi, or gastrointestinal tract occurred when mice were exposed to doxycycline from embryonic day (E) 4...
  26. ncbi Ultrasound-guided percutaneous dilatational tracheostomy: a safe method to avoid cranial misplacement of the tracheostomy tube
    A Sustic
    Department of Anaesthesiology and ICU, University Hospital Rijeka, Croatia
    Intensive Care Med 26:1379-81. 2000
    ..05) and four (36%) patients had a broken tracheal ring (P = NS). The authors maintain that by using ultrasound-guided PDT cranial misplacement of the tracheostomy tube may be entirely avoided...
  27. ncbi The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension
    L Glazer
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 5:697-705. 1991
    ..However, the extension of tracheal cell processes leading to the formation of the elaborate tree structure is blocked. The DFGF-R protein may thus participate in receiving spatial cues that guide tracheal cell outgrowth...
  28. pmc Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation
    George Gallos
    Dept of Anesthesiology, College of Physicians and Surgeons of Columbia Univ, 650 W 168 St, P and S Box 46, New York, NY, USA
    Am J Physiol Lung Cell Mol Physiol 295:L1040-7. 2008
    ....
  29. ncbi Four chamber view plus three-vessel and trachea view for a complete evaluation of the fetal heart during the second trimester
    Antongiulio Del Bianco
    Dipartimento Materno Infantile, Unità Operativa di Ostetricia e Ginecologia 2, Policlinico Univesitario, Foggia, Italy
    J Perinat Med 34:309-12. 2006
    To test the efficacy of a recently introduced ultrasonic scanning plane (three vessel and trachea view -3VTV- plus color flow mapping -3VTVC) on a low-risk population for detection of congenital heart disease (CHD).
  30. ncbi Clinical transplantation of a tissue-engineered airway
    Paolo Macchiarini
    Department of General Thoracic Surgery, Hospital Clinic, Barcelona, Spain
    Lancet 372:2023-30. 2008
    ..We aimed to bioengineer tubular tracheal matrices, using a tissue-engineering protocol, and to assess the application of this technology in a patient with end-stage airway disease...
  31. ncbi Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors
    Y Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Pharmacol 60:1201-9. 2001
    ..situ hybridization experiments detected alpha7 subunit mRNA in cultured human BEC and AEC and in sections of rat trachea. The binding of radiolabeled alpha-bungarotoxin revealed a few thousand binding sites per cell in cultured human ..
  32. doi Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy
    Sundeep G Keswani
    The Center for Molecular Fetal Therapy, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Surg 46:33-8. 2011
    Our previous work in a human-fetal trachea xenograft model suggests potential benefits of treating cystic fibrosis in utero. The target for postnatal gene therapy in cystic fibrosis is tracheal submucosal glands (SMGs)...
  33. pmc Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 101:4620-4. 2004
    ..Our data throw light on the mechanisms of generation of pandemic viruses from their avian progenitors and open avenues for cell level-oriented studies on the replication and pathogenicity of influenza virus in humans...
  34. pmc KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels
    Bin Nan Wu
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Br J Pharmacol 142:1105-14. 2004
    ..KMUP-1 (0.01-100 microm) induced concentration-dependent relaxation responses in guinea-pig epithelium-intact trachea precontracted with carbachol...
  35. pmc Prenatal and early postnatal morphogenesis and growth of human laryngotracheal structures
    Pierre Fayoux
    Department of Otolaryngology Head and Neck Surgery, University Hospital of Lille, France
    J Anat 213:86-92. 2008
    ..An anatomical prospective study was based on examination of larynx and trachea from 300 routine autopsies of fetuses and infants, free of malformation and never intubated...
  36. ncbi Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea
    Peter J Henry
    School of Medicine and Pharmacology, University of Western Australia, Nedlands
    J Pharmacol Exp Ther 314:995-1001. 2005
    ..capacity of SLIGRL to elevate PGE(2) levels and produce relaxation in isolated segments of upper and lower mouse trachea. SLIGRL produced concentration-dependent increases in PGE(2) levels and smooth muscle relaxation, although both ..
  37. ncbi Late complications of tracheostomy
    Scott K Epstein
    Department of Medicine, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston MA 02135, USA
    Respir Care 50:542-9. 2005
    ..For the most frequent complication, tracheal stenosis, a multidisciplinary approach utilizing bronchoscopy, laser, airway stents, and tracheal surgery is most effective...
  38. doi Pathogenicity of a QX strain of infectious bronchitis virus in specific pathogen free and commercial broiler chickens, and evaluation of protection induced by a vaccination programme based on the Ma5 and 4/91 serotypes
    Calogero Terregino
    OIE FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell Universita 10, Legnaro PD, Italy
    Avian Pathol 37:487-93. 2008
    ..This study confirms that vaccination at 1 day old and at 14 days of age using the Ma5 and 4/91 IB vaccines may be instrumental in reducing the economic impact of QX IB virus infections in layer and broiler farms...
  39. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    The mammalian respiratory system, consisting of both trachea and lung, initiates from the foregut endoderm. The molecular program that instructs endodermal cells to adopt the respiratory fate is not fully understood...
  40. ncbi Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea
    Agung Endro Nugroho
    Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia
    Pak J Pharm Sci 24:427-33. 2011
    ..In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80...
  41. pmc New quantitative patterns of the growing trachea in human fetuses
    Michał Szpinda
    Department of Normal Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland
    Med Sci Monit 18:PH63-70. 2012
    ..Rapid progress in perinatal medicine has resulted in numerous tracheo-bronchial interventions on fetal and neonatal airways. The present study was performed to compile normative data for tracheal dimensions at varying gestational ages...
  42. ncbi Tracheal agenesis with unique anatomy
    Nia Fraser
    Department of Paediatric Surgery, Nottingham Hospitals NHS Trust, Queens Medical Centre, NG7 2UH Nottingham, UK
    J Pediatr Surg 40:e7-10. 2005
    ..The possibility of surgical correction rests on early diagnosis, anatomy, birth weight, and associated anomalies. Early recognition is mandatory, but in our case, the low birth weight precluded consideration for reconstructive surgery...
  43. ncbi Percutaneous fetal endoscopic tracheal occlusion (FETO) for severe left-sided congenital diaphragmatic hernia
    J Jani
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Obstet Gynecol 48:910-22. 2005
  44. ncbi Determination of endotracheal tube size in a perinatal population: an anatomical and experimental study
    Pierre Fayoux
    Service d Oto Rhino Laryngologie ORL et Chirurgie CervicoFaciale Hôpital Huriez, Centre Hospitalier Regional Universitaire CHRU Lille, France
    Anesthesiology 104:954-60. 2006
    This study aimed at correlating anatomical dimensions of the larynx and trachea to age and weight in a prenatal population. Endotracheal tube size determination was then proposed according to these considerations.
  45. pmc The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control
    Kevin S Nelson
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Genetics 185:831-9. 2010
    ..Double- and triple-mutant combinations of Sinuous and Megatrachea with Kune-kune resemble the Kune-kune single mutant, suggesting that Kune-kune has a more central role in septate junction formation than either Sinuous or Megatrachea...
  46. pmc Real-time ultrasound-guided percutaneous dilatational tracheostomy: a feasibility study
    Venkatakrishna Rajajee
    Department of Neurosurgery and Neurology, University of Michigan Health System, 3552 Taubman Health Care Center, 1500 E, Medical Center Dr, SPC 5338, Ann Arbor, MI 48109 5338, USA
    Crit Care 15:R67. 2011
    ..Our objective was to demonstrate that PT performed under real-time US guidance with visualization of needle path during tracheal puncture is feasible, including in patients with features that increase the technical difficulty of PT...
  47. doi Telocytes in trachea and lungs
    Y Zheng
    Department of Pulmonary Medicine and Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 15:2262-8. 2011
    We show the existence of a novel type of interstitial cell-telocytes (TC) in mouse trachea and lungs...
  48. pmc Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach
    Ying Wang
    Department of Poultry Science, Texas A and M University College Station, TX 77843 2472, USA
    BMC Genomics 10:512. 2009
    ..Avian influenza virus (AIV) not only causes significant economic losses in poultry production, but also is of great concern to human health. The objective of this study was to identify miRNAs associated with AIV infections in chickens...
  49. pmc Tracheal Basal cells: a facultative progenitor cell pool
    Brook B Cole
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, Colorado, USA
    Am J Pathol 177:362-76. 2010
    ..In this study, we used gene expression and histomorphometric analysis of the steady-state and naphthalene-injured trachea to evaluate the predictions of this model...
  50. ncbi Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways
    Ofir Bachar
    Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
    Eur J Immunol 34:1196-207. 2004
    ..Costimulation of these receptors results in NF-kappa B- and JNK-mediated transcription of B(1) and B(2) receptor, inducing hyper-responsiveness to bradykinin...
  51. ncbi The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells
    Ian Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur J Pharmacol 531:9-12. 2006
    ..05). Therefore, beta2-adrenoceptor agonists can augment spasmogen responses in airway smooth muscle but not via a G-protein/PLC-beta1 mediated mechanism...
  52. pmc A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea
    K Iizuka
    First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Br J Pharmacol 128:925-33. 1999
    ..5'-O-(3-thiotriphosphate) (GTPgammaS)-induced contraction in alpha-toxin- or beta-escin-permeabilized rabbit trachea. 2 Although pre-treatment with Y-27632 dose-dependently inhibited GTPgammaS (10 microM)-induced Ca2+ ..
  53. ncbi Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Differentiation 74:422-37. 2006
    ..endoderm, the folding of the endoderm into a foregut tube, and the subsequent separation of the foregut tube into trachea and esophagus...
  54. pmc A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea
    Monn Monn Myat
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Biol 281:38-52. 2005
    ..These studies support a model in which both the Dpp- and the FGF-signaling pathways control expression of knirps and knirps-related, thereby regulating cell migration during dorsal branch formation...
  55. ncbi Lung epithelial cells release ATP during ozone exposure: signaling for cell survival
    Shama Ahmad
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Free Radic Biol Med 39:213-26. 2005
    ..Thus, extracellularly released ATP signals to prevent ozone-induced death and supplementation with ATP or its analogs can augment protection, at least in part via Akt and /or ERK signaling pathways and their metabolic effects...
  56. doi Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death
    Katrin Anne Becker
    Dept of Molecular Biology, University of Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Biochem Biophys Res Commun 403:368-74. 2010
    ..In this study we investigated whether ceramide concentrations are also altered in the trachea and the intestine of cystic fibrosis mice and whether an accumulation of ceramide in these organs has functional ..
  57. pmc cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways
    Robert J Lee
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6085, USA
    J Clin Invest 120:3137-48. 2010
    ..These results identify important molecular mechanisms of cAMP-dependent secretion, including a requirement for Ca2+ signaling, and suggest new therapeutic approaches to correct defective submucosal gland secretion in CF...
  58. pmc Analysis of component findings in 79 patients diagnosed with VACTERL association
    Benjamin D Solomon
    Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Am J Med Genet A 152:2236-44. 2010
    ..These findings have implications for both our understanding of VACTERL association and for the approach to research involving this condition...
  59. doi Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in Drosophila
    Dominique Förster
    Institute of Zoology, Universitat Zurich, CH 8057 Zurich, Switzerland
    Curr Biol 20:62-8. 2010
    ..These results indicate a critical role of membrane-associated proteins in the process and imply a mechanism that coordinates autonomous behaviors of individual cells within epithelial structures...
  60. pmc The replicase gene of avian coronavirus infectious bronchitis virus is a determinant of pathogenicity
    Maria Armesto
    Division of Microbiology, Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire, United Kingdom
    PLoS ONE 4:e7384. 2009
    ....
  61. pmc Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium
    Philip Thai
    Center for Comparative Respiratory Biology and Medicine, Surge 1, Room 1121, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Am J Respir Cell Mol Biol 33:523-30. 2005
    ..Thus, these results suggest that the two biomakers of the metaplastic airway mucous cell type are differentially regulated by JAK/STAT6-dependent and -independent pathways...
  62. pmc IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    Omar Tliba
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Br J Pharmacol 140:1159-62. 2003
    ..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
  63. pmc Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells
    Aida Ibricevic
    Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 80:7469-80. 2006
    ....
  64. ncbi Hyperoxia impairs airway relaxation in immature rats via a cAMP-mediated mechanism
    Maroun J Mhanna
    Department of Pediatrics, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH 44109, USA
    J Appl Physiol (1985) 96:1854-60. 2004
    ..EFS-induced relaxation of preconstricted trachea was diminished in hyperoxic vs. normoxic animals (P < 0.05)...
  65. ncbi Regulation of early lung morphogenesis: questions, facts and controversies
    Wellington V Cardoso
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Development 133:1611-24. 2006
    ..Here, we review early stages in lung development and highlight questions and controversies regarding their molecular regulation...
  66. ncbi Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium
    Mitsuko Kondo
    First Department of Medicine, Tokyo Women s Medical University, School of Medicine, Japan
    Am J Respir Cell Mol Biol 27:536-41. 2002
    ..In this study, primary epithelial cells from guinea pig trachea were cultured at an air-liquid interface, and immediately after achieving confluence at Day 7 they were treated ..
  67. pmc Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia
    Nathan T Mortimer
    Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Dev Biol 329:294-305. 2009
    ..The identification of an early stage of tracheal development that is vulnerable to hypoxia is an important addition to models of the invertebrate hypoxic response...
  68. ncbi Tracheal occlusion stimulates cell cycle progression and type I cell differentiation in lungs of fetal rats
    Jyoji Yoshizawa
    Department of Veteran Affairs, University of California, San Francisco, CA 94118, USA
    Am J Physiol Lung Cell Mol Physiol 285:L344-53. 2003
    ..We examined effects of a novel method of TO (unipolar microcautery to seal the trachea) produced at 19.5-20 days (d) of gestation in fetal rats; fetuses were delivered at term, 22 d...
  69. ncbi IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
    M M Grunstein
    Division of Pulmonary Medicine, Joseph Stokes, Jr Research Institute, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 282:L520-8. 2002
    ....
  70. ncbi sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
    N Hacohen
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 92:253-63. 1998
    ..sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development...
  71. pmc Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses
    Aravind Srinivasan
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:2800-5. 2008
    ..In summary, this study establishes a quantitative biochemical correlate for influenza A virus transmission...
  72. ncbi Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1)
    D Duan
    Department of Anatomy and Cell Biology and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Development 126:4441-53. 1999
    ..is upregulated in submucosal gland progenitor cells just prior to gland bud formation in the developing ferret trachea. In the current report, several animal models were utilized to functionally investigate the role of LEF1 in ..
  73. ncbi A method of endotracheal intubation and pulmonary functional assessment for repeated studies in mice
    R H Brown
    Department of Anesthesiology, Environmental Health Sciences Division of Physiology, and Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 87:2362-5. 1999
    The ability to successfully intubate the trachea of mice and control their ventilation is important for longitudinal studies requiring recovery from anesthesia and repeated pulmonary function measurements or other evaluations, such as ..
  74. ncbi EGF signalling regulates cell invagination as well as cell migration during formation of tracheal system in Drosophila
    M Llimargas
    Centre d Investigació i Desenvolupament CSIC, C Jordi Girona 18 26, E 08034 Barcelona, Spain
    Dev Genes Evol 209:174-9. 1999
    ..We discuss how the consecutive steps of tracheal morphogenesis might affect the final branching pattern...
  75. ncbi A novel murine beta -defensin expressed in tongue, esophagus, and trachea
    H P Jia
    Departments of Pediatrics, Genetics Ph D Program, and Microbiology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 275:33314-20. 2000
    ..The peptide shares approximately 40% identity with HBD-2. MBD-4 mRNA was expressed in the esophagus, tongue, and trachea but not in any of 20 other tissues surveyed...
  76. pmc A mathematical model of airway and pulmonary arteriole smooth muscle
    Inga Wang
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    Biophys J 94:2053-64. 2008
    ..In addition, the model also predicts that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration...
  77. doi boudin is required for septate junction organisation in Drosophila and codes for a diffusible protein of the Ly6 superfamily
    Assia Hijazi
    Université de Toulouse UPS, Centre de Biologie du Developpement, CNRS UMR 5547, Bâtiment 4R3, 118 route de Narbonne, F 31062 Toulouse, France
    Development 136:2199-209. 2009
    ..Our work opens the way for future studies addressing the function of Ly6 proteins using Drosophila as a model system...
  78. ncbi Tracheal agenesis revisited: analysis of associated anomalies
    J A Evans
    Department of Human Genetics, University of Manitoba and Children s Hospital, Winnipeg, Canada
    Am J Med Genet 82:415-22. 1999
    ..Anomalies in the first group were primarily restricted to the trachea, larynx, and cardiovascular system...
  79. ncbi Where's the tube? Evaluation of hand-held ultrasound in confirming endotracheal tube placement
    Rosaleen Chun
    Department of Anesthesia, Foothills Medical Centre, Calgary, Alberta, Canada
    Prehosp Disaster Med 19:366-9. 2004
    ..Thoracic sonography, previously utilized to detect pneumothoraces, has not been tested to assess ETT placement...
  80. ncbi A composite tissue-engineered trachea using sheep nasal chondrocyte and epithelial cells
    Koji Kojima
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    FASEB J 17:823-8. 2003
    ..Implants were harvested 4 wk later and analyzed. The morphology of implants resembles that of native sheep trachea. H&E staining shows the presence of mature cartilage and formation of a pseudo-stratified columnar epithelium,..
  81. pmc Tubulogenesis: an inside job
    Lianna E Swanson
    Northwestern University, Evanston, Illinois 60208 3500, USA
    Curr Biol 16:R51-3. 2006
  82. ncbi The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine trachea
    F Grahammer
    Institute of Physiology, Albert Ludwigs Universitat, Hermann Herder Strabetae 7, D 79104 Freiburg, Germany
    J Biol Chem 276:42268-75. 2001
    ..As described for colonic epithelium, the current through KCNQ1 complexes in murine trachea is specifically inhibited by the chromanol 293B...
  83. pmc Differentiated cultures of primary hamster tracheal airway epithelial cells
    Regina K Rowe
    Molecular Microbiology and Microbial Pathogenesis Graduate Program, Washington University School of Medicine, St Louis, Missouri 63110, USA
    In Vitro Cell Dev Biol Anim 40:303-11. 2004
    ....
  84. ncbi A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells
    Charlotte K Billington
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Am J Respir Cell Mol Biol 38:1-7. 2008
    ..These data suggest that PDE4D5, despite being a minor component of the tissue PDE pool, is the key physiological regulator of beta(2)AR-induced cAMP turnover within human airway smooth muscle...
  85. ncbi A simple method to predict pretracheal tissue thickness to prevent accidental decannulation in the obese
    Christopher Szeto
    Department of Otolaryngology Head and Neck Surgery, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Otolaryngol Head Neck Surg 143:223-9. 2010
    ..Our purpose was to 1) establish the range of trachea-to-skin soft tissue thickness (TTSSTT) in obese patients and 2) determine which easily obtained anthropometric ..
  86. ncbi Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of beta(2)-adrenoceptors
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Science, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    J Smooth Muscle Res 41:153-61. 2005
    ..adrenaline-induced relaxation was pharmacologically identified in smooth muscle cells of the isolated guinea-pig trachea. Adrenaline produced a concentration-dependent relaxation with a pD(2) value of 7.1...
  87. pmc Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors
    Jenny Hallgren
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:20478-83. 2007
    ..Thus, these studies demonstrate a role for a chemokine receptor in regulating endothelial VCAM-1 expression, MCp migration, and the level of intraepithelial MC in the lung of aerosolized, antigen-challenged mice...
  88. ncbi Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivo
    Heather MacPherson
    MRC Human Genetics Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK
    J Cell Sci 118:2441-50. 2005
    ..that mice engrafted with side population cells have donor-derived cells present in the epithelial lining of the trachea following damage and repair. Donor-derived cells were found at a frequency of 0.83%...
  89. pmc Analysis of FOXF1 and the FOX gene cluster in patients with VACTERL association
    Nneamaka B Agochukwu
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 35, Room 1B207, 35 Convent Drive MSC 3717, Bethesda, MD 20892 3717, United States
    Eur J Med Genet 54:323-8. 2011
    ....
  90. doi Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glands
    Monal Khansaheb
    Cystic Fibrosis Research Laboratory, Stanford Univ, CA 94305 2130, USA
    Am J Physiol Lung Cell Mol Physiol 300:L370-9. 2011
    ..These and prior results suggest that SubP stimulates pig gland secretion via CFTR- and Ca(2+)-activated Cl(-) channels...
  91. ncbi Ultrasound-guided percutaneous dilatational tracheostomy with laryngeal mask airway control in a morbidly obese patient
    Alan Sustic
    Department of Anesthesiology and ICU, University Hospital Rijeka, Rijeka, Croatia
    J Clin Anesth 16:121-3. 2004
    ..Possible advantages of an ultrasonography-guided method and LMA control in morbidly obese patients also are discussed...
  92. doi Anatomical variation in the position of the brachiocephalic trunk (innominate artery) with respect to the trachea: a computed tomography-based study and literature review of Innominate Artery Compression Syndrome
    S L Fawcett
    Department of Radiology, Cambridge University Teaching Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
    Clin Anat 23:61-9. 2010
    ..has been controversially attributed to an anomalous origin of this vessel to the left of, and hence crossing, the trachea. The aim of this study was to establish the normal relationship between the BT and trachea in infants, children, ..
  93. ncbi Post-intubation tracheal injury: report of three cases and literature review
    Carlos Remolina Medina
    Pavilhão Pereira Filho, Complexo Hospitalar Santa Casa, Porto Alegre, RS, Brasil
    J Bras Pneumol 35:809-13. 2009
    ..We report the cases of three patients presenting tracheal laceration due to traumatic orotracheal intubation, two submitted to surgical treatment and one submitted to conservative treatment...
  94. ncbi Anatomy of the trachea, carina, and bronchi
    Douglas J Minnich
    Division of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Blake 1570, Boston, MA 02114, USA
    Thorac Surg Clin 17:571-85. 2007
    ..In addition, the more precise delineation of tracheal anatomy has contributed largely to the advancement of airway surgery in recent years. This article serves as a foundation for learning or reviewing this important topic...
  95. ncbi The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance
    N Wienkötter
    Department of Pharmacology, Institute of Medicinal Chemistry, Munster, Germany
    Planta Med 74:105-8. 2008
    NIGELLA SATIVA L. has many effects including those on the gastrointestinal tract and trachea and is, therefore, used in the Mediteranean area and in India/Pakistan...
  96. pmc 5q11.2 deletion in a patient with tracheal agenesis
    Elisabeth M de Jong
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 18:1265-8. 2010
    ..No common deletions or duplications are found in our cohort, suggesting that TA is a genetically heterogeneous disorder...
  97. ncbi The gross anatomy of larynx, trachea and syrinx in the long-legged buzzard (Buteo rufinus)
    M Kabak
    Department of Anatomy, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Kurupelit Samsun, Turkey
    Anat Histol Embryol 36:27-32. 2007
    ..The partially ossified corpus and ala of the cricoid cartilage were connected with cartilaginous plate. Trachea was formed up of complete cartilage circles...
  98. ncbi Nontraumatic disruption of the fibrocartilaginous trachea: causes and clinical outcomes
    Michelle R Aerni
    Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    Chest 130:1143-9. 2006
    Nontraumatic disruption of the fibrocartilaginous trachea is rare, and the appropriate management of this condition is not well-characterized.
  99. ncbi Agreement between quantitative cultures of postintubation tracheal aspiration and plugged telescoping catheter, protected specimen brush, or BAL for the diagnosis of nosocomial pneumonia
    Christophe Clec'h
    Service de Reanimation, Hopital Avicenne, 125, route de Stalingrad, 93009 Bobigny Cedex, France
    Chest 130:956-61. 2006
    ..Our aim was to compare the diagnostic accuracy of PITA to that of PSB, BAL, or PTC in patients requiring MV for suspected NP...
  100. ncbi Role of potassium channels in the relaxant effect of levosimendan in guinea pig tracheal preparations
    Bilsen Eksert
    Department of Pharmacology, Akdeniz University, Medical Faculty, Antalya, Turkey
    Pharmacol Rep 61:275-80. 2009
    ..The present findings suggested that the relaxant effect induced by levosimendan might be partially due to K(ATP) and BK Ca in isolated guinea pig tracheal rings...
  101. ncbi Ultrasound-guided localisation of the trachea
    J A Orr
    Anaesthesia 62:972-3. 2007

Research Grants75

  1. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2010
    ..In Specific Aim 1, basal cells will be purified from the trachea of normal mice and from mutant mice lacking functional NGFR...
  2. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ..to diacetyl (2,3 butadiene), a major component of butter flavoring vapors, results in necrosis of the nasal and trachea, but not the intrapulmonary airways...
  3. CIGARETTE SMOKE-INDUCED DAMAGE IN GUINEA PIGS--MODULATION BY VITAMINS C&E
    Emerich Fiala; Fiscal Year: 1999
    ..specific aims are:, 1) To determine oxidative damage to DNA, RNA, proteins and lipids of the guinea pig lung and trachea produced by chronic exposure to cigarette smoke; 2) To systematically vary the dietary levels of vitamins C and E ..
  4. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2005
    ..During intubation of the trachea, parasympathetic nerves release acetylcholine that act on M3 muscarinic receptors on airway smooth muscle to ..
  5. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2006
    ..During intubation of the trachea, parasympathetic nerves release acetylcholine that act on M3 muscarinic receptors on airway smooth muscle to ..
  6. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2004
    ..During intubation of the trachea, parasympathetic nerves release acetylcholine that act on M3 muscarinic receptors on airway smooth muscle to ..
  7. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2003
    ..During intubation of the trachea, parasympathetic nerves release acetylcholine that act on M3 muscarinic receptors on airway smooth muscle to ..
  8. MECHANISMS OF AIR POLLUTANT INDUCED AIRWAY PERMEABILITY
    DEEPAK BHALLA; Fiscal Year: 1990
    ..response, cytoskeletal changes, tight junction alterations and structural pathways of tracer transport in the trachea and alveoli in: (1) rats exposed to air only or O3(O.6 ppm) or O3 (O.6 ppm) + NO2 (2...
  9. LUNG AND AIRWAY AFFERENTS AND THEIR REFLEX ROLE
    JOHN COLERIDGE; Fiscal Year: 1990
    ..Secretion will be assessed by counting tantalum-coated secretory "hillocks" in the upper trachea. 2) To determine the effects of stimulating lung sympathetic afferents of airway secretion, tracheal smooth ..
  10. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip Boiselle; Fiscal Year: 2009
    ..Acquired tracheomalacia, a condition defined by excessive expiratory collapse of the trachea due to weakness of the airway walls and/or supporting cartilage, is a relatively common but frequently overlooked ..
  11. AIR CONDITIONING BY THE TRACHEA--STIMULI AND MECHANISMS
    Mark Deffebach; Fiscal Year: 1990
    ..As ventilation increases, the trachea becomes a major source of the heat and water required for the conditioning of inspired air...
  12. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2006
    ..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
  13. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
  14. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
  15. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2007
    ..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
  16. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2010
    ..To address these aims, a mouse model will be used. The trachea, bronchi, and lungs with the vagus nerve and vagal sensory ganglia will obtained from mice actively sensitized to ..
  17. Bordetella pathogenesis: an undergraduate research tool
    Louise M Temple; Fiscal Year: 2010
    ..We have developed an explant culture system for ciliated cells from embryonic turkey trachea and purified cilia from adult turkey trachea...
  18. Bordetella pathogenesis: an undergraduate research tool
    Louise Temple; Fiscal Year: 2007
    ..We have developed an explant culture system for ciliated cells from embryonic turkey trachea and purified cilia from adult turkey trachea...
  19. Bordetella pathogenesis: an undergraduate research tool
    Louise Temple; Fiscal Year: 2009
    ..We have developed an explant culture system for ciliated cells from embryonic turkey trachea and purified cilia from adult turkey trachea...
  20. EPITHELIAL FUNCTION--REGULATION IN AIRWAY RESPONSIVENESS
    Steven White; Fiscal Year: 1993
    ..Guinea pig trachea] epithelial cells in primary culture will be co-cultured with human peripheral blood eosinophils or eosinophil ..
  21. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2009
    ..it serves functional and structural roles, including the support of soft tissue (ear and nose), airway patency (trachea), phonation (larynx), and joint movement (i.e.,TMJ)...
  22. Coaxial Everting Membrane Catheter Bronchoalveolar Lavag
    William Krause; Fiscal Year: 2006
    ..However, sputum (lung, trachea or oropharyngeal secretions) is often contaminated by saliva, oropharyngeal organisms and squamous cells that are ..
  23. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..it serves functional and structural roles, including the support of soft tissue (ear and nose), airway patency (trachea), phonation (larynx), and joint movement (i.e.,TMJ)...
  24. IRE1beta: A Novel Pathway for Regulation of Airway Epithelial Mucin Production
    Carla Maria Pedrosa Ribeiro; Fiscal Year: 2010
    ..5-8.5 fold higher than IRE1a expression in nasopharynx, trachea, and bronchus, tissues that exhibit higher levels of mucous cells...
  25. Kinematic Modeling of Asymmetric Vocal Fold Vibration
    ROBIN AMY SAMLAN; Fiscal Year: 2010
    ..The inclusion of a trachea and vocal tract in the system allows for additional testing of the effect of airspace on the resulting output ..
  26. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2004
    ..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, ..
  27. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2002
    ..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, ..
  28. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2003
    ..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, ..
  29. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2006
    Epithelial cells lining the mammalian trachea form a crucial site in the host defense against airborne microbial pathogens, releasing numerous antimicrobial factors...
  30. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2004
    Epithelial cells lining the mammalian trachea form a crucial site in the host defense against airborne microbial pathogens, releasing numerous antimicrobial factors...
  31. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2003
    Epithelial cells lining the mammalian trachea form a crucial site in the host defense against airborne microbial pathogens, releasing numerous antimicrobial factors...
  32. GENERATION & DEVELOPMENT OF FETAL BREATHING MOVEMENT
    EMILE SCARPELLI; Fiscal Year: 1980
    ..by temperature, particularly core body temperature and that the onset of breathing in the fetus in which the trachea is occluded has the characteristics of the "progressive response to airway occlusion" which has been described in ..
  33. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2005
    Epithelial cells lining the mammalian trachea form a crucial site in the host defense against airborne microbial pathogens, releasing numerous antimicrobial factors...
  34. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1993
    ..class of inflammatory mediators are the leukotrienes C4 and D4 (LTC4 and LTD4) which when applied to gut, trachea, and pure cultures of sensory neurons elicit release of the tachykinins substance P (SP) and substance K (SK)...
  35. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1990
    ..class of inflammatory mediators are the leukotrienes C4 and D4 (LTC4 and LTD4) which when applied to gut, trachea, and pure cultures of sensory neurons elicit release of the tachykinins substance P (SP) and substance K (SK)...
  36. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2004
    ..3) To develop methods to measure the pressure-area characteristics of the trachea in patients undergoing bronchoscopy and to determine whether the site of expiratory flow limitation in these ..
  37. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2001
    ..3) To develop methods to measure the pressure-area characteristics of the trachea in patients undergoing bronchoscopy and to determine whether the site of expiratory flow limitation in these ..
  38. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2002
    ..3) To develop methods to measure the pressure-area characteristics of the trachea in patients undergoing bronchoscopy and to determine whether the site of expiratory flow limitation in these ..
  39. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2003
    ..3) To develop methods to measure the pressure-area characteristics of the trachea in patients undergoing bronchoscopy and to determine whether the site of expiratory flow limitation in these ..
  40. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles Emala; Fiscal Year: 2009
    ..Intubation of the trachea during induction or the presence of an endotracheal tube during emergence from anesthesia initiates a neurally-..
  41. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles Emala; Fiscal Year: 2007
    ..Intubation of the trachea during induction or the presence of an endotracheal tube during emergence from anesthesia initiates a neurally-..
  42. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles W Emala; Fiscal Year: 2010
    ..Intubation of the trachea during induction or the presence of an endotracheal tube during emergence from anesthesia initiates a neurally-..
  43. GENE THERAPY IN MUCOPLYSACCHARIDOSIS VII
    Mark Haskins; Fiscal Year: 2004
    ..VII, the dogs are growth-retarded, have a facial dysmorphia, corneal clouding, thickened heart valves, a narrow trachea, deformed sternum, and synovial joints with progressive degenerative lesions of the articular cartilage such that ..
  44. GENE THERAPY IN MUCOPLYSACCHARIDOSIS VII
    Mark Haskins; Fiscal Year: 2006
    ..VII, the dogs are growth-retarded, have a facial dysmorphia, corneal clouding, thickened heart valves, a narrow trachea, deformed sternum, and synovial joints with progressive degenerative lesions of the articular cartilage such that ..
  45. GENE THERAPY IN MUCOPLYSACCHARIDOSIS VII
    Mark Haskins; Fiscal Year: 2003
    ..VII, the dogs are growth-retarded, have a facial dysmorphia, corneal clouding, thickened heart valves, a narrow trachea, deformed sternum, and synovial joints with progressive degenerative lesions of the articular cartilage such that ..
  46. GENE THERAPY IN MUCOPLYSACCHARIDOSIS VII
    Mark Haskins; Fiscal Year: 2005
    ..VII, the dogs are growth-retarded, have a facial dysmorphia, corneal clouding, thickened heart valves, a narrow trachea, deformed sternum, and synovial joints with progressive degenerative lesions of the articular cartilage such that ..
  47. NEURAL REGULATION OF PANCREATIC FUNCTION
    Kimberly Kirkwood; Fiscal Year: 2002
    ..The regulation of pancreatic inflammation is poorly understood. In the trachea, sensory nerves regulate inflammation by releasing tachykinins that bind to endothelial cells and induce ..
  48. NEURAL REGULATION OF PANCREATIC FUNCTION
    Kimberly Kirkwood; Fiscal Year: 1999
    ..The regulation of pancreatic inflammation is poorly understood. In the trachea, sensory nerves regulate inflammation by releasing tachykinins that bind to endothelial cells and induce ..
  49. NEURAL REGULATION OF PANCREATIC FUNCTION
    Kimberly Kirkwood; Fiscal Year: 2000
    ..The regulation of pancreatic inflammation is poorly understood. In the trachea, sensory nerves regulate inflammation by releasing tachykinins that bind to endothelial cells and induce ..
  50. NEURAL REGULATION OF PANCREATIC FUNCTION
    Kimberly Kirkwood; Fiscal Year: 2001
    ..The regulation of pancreatic inflammation is poorly understood. In the trachea, sensory nerves regulate inflammation by releasing tachykinins that bind to endothelial cells and induce ..
  51. MOLECULAR BIOLOGY OF LUNG ANTIOXIDANT ENZYME REGULATION
    Brooke Mossman; Fiscal Year: 1993
    ..concentrations, PKC activity, and the hydrolysis of phosphoinositides in HTE cells and in primary isolates of rat trachea] epithelial cells (RTE) and rat lung fibroblasts (RLF)...
  52. PULMONARY DEFENSES IN OPPORTUNISTIC INFECTIONS
    Mary Lipscomb; Fiscal Year: 1990
    ..In the murine model the organism is inoculated via the trachea and first establishes an infection in the lung...
  53. Artificial Hand's Seeing Fingers: A New Device for Ingested Foreign Bodies Remova
    VLADIMIR RUBTSOV; Fiscal Year: 2010
    ..hold on the object as it is being removed and as the esophagus relaxes often causes the object to go into the trachea, resulting in death...
  54. DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELS
    Timothy Wiedmann; Fiscal Year: 2000
    Mucus occurs throughout the body at epithelial surfaces in the trachea, gall bladder, cervix, eye, bladder, and in saliva as well as along the gastrointestinal tract...
  55. DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELS
    Timothy Wiedmann; Fiscal Year: 1999
    Mucus occurs throughout the body at epithelial surfaces in the trachea, gall bladder, cervix, eye, bladder, and in saliva as well as along the gastrointestinal tract...
  56. OZONE DOSIMETRY USING RADIOACTIVE AND STABLE ISOTOPES
    Michael Russell; Fiscal Year: 1993
    ..The radioactivity of major tissues such as the nasopharynx, trachea, individual lung lobes, and extra-pulmonary tissues will be measured using a gamma-ray counter...
  57. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2009
    ..We will focus on two epithelia, the epididymis, which is at the core of our research program, and the trachea. The epididymis, which connects the testis to the vas deferens, is involved in the maturation and storage of ..
  58. Artificial Hand's Seeing Fingers: A New Device for Ingested Foreign Bodies Remova
    VLADIMIR RUBTSOV; Fiscal Year: 2009
    ..hold on the object as it is being removed and as the esophagus relaxes often causes the object to go into the trachea, resulting in death...
  59. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2010
    ..We will focus on two epithelia, the epididymis, which is at the core of our research program, and the trachea. The epididymis, which connects the testis to the vas deferens, is involved in the maturation and storage of ..
  60. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1991
    ..NNK induces tumors of the lung, trachea and nasal cavity in Syrian golden hamsters; the lung, nasal cavity, liver an pancreas of F344 rats; and the lung ..
  61. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1993
    ..NNK induces tumors of the lung, trachea and nasal cavity in Syrian golden hamsters; the lung, nasal cavity, liver an pancreas of F344 rats; and the lung ..
  62. LUNG EPITHELIAL ION-LIQUID TRANSPORT DURING DEVELOPMENT
    Richard Bland; Fiscal Year: 1993
    ..changes of ion transport in cells derived from 2 distinct regions of the respiratory tract epithelium (trachea, distal lung) of 2 species (rabbits, sheep), and to relate these changes to developmental differences in lung ..
  63. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2001
    ..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, ..