trachea

Summary

Summary: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

Top Publications

  1. pmc Basal cells as stem cells of the mouse trachea and human airway epithelium
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:12771-5. 2009
  2. ncbi Telocytes in trachea and lungs
    Y Zheng
    Department of Pulmonary Medicine and Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 15:2262-8. 2011
  3. ncbi Clinical transplantation of a tissue-engineered airway
    Paolo Macchiarini
    Department of General Thoracic Surgery, Hospital Clinic, Barcelona, Spain
    Lancet 372:2023-30. 2008
  4. ncbi Tube morphogenesis: making and shaping biological tubes
    Barry Lubarsky
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Cell 112:19-28. 2003
  5. ncbi Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population
    Yingjian You
    Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1315-21. 2002
  6. pmc A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets
    Akila Jayaraman
    Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17616. 2011
  7. ncbi Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 135:2055-64. 2008
  8. ncbi Trachea-derived dpp controls adult midgut homeostasis in Drosophila
    Zhouhua Li
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Cell 24:133-43. 2013
  9. pmc Multiple roles for Sox2 in the developing and adult mouse trachea
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 136:1899-907. 2009
  10. ncbi Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 120:2749-71. 1994

Detail Information

Publications287 found, 100 shown here

  1. pmc Basal cells as stem cells of the mouse trachea and human airway epithelium
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:12771-5. 2009
    The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14...
  2. ncbi Telocytes in trachea and lungs
    Y Zheng
    Department of Pulmonary Medicine and Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 15:2262-8. 2011
    We show the existence of a novel type of interstitial cell-telocytes (TC) in mouse trachea and lungs...
  3. ncbi Clinical transplantation of a tissue-engineered airway
    Paolo Macchiarini
    Department of General Thoracic Surgery, Hospital Clinic, Barcelona, Spain
    Lancet 372:2023-30. 2008
    ..We aimed to bioengineer tubular tracheal matrices, using a tissue-engineering protocol, and to assess the application of this technology in a patient with end-stage airway disease...
  4. ncbi Tube morphogenesis: making and shaping biological tubes
    Barry Lubarsky
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Cell 112:19-28. 2003
    ..We propose a unifying mechanism of tube morphogenesis that has been modified to create tube diversity and describe how defects in the tube size-sensing step can lead to polycystic kidney disease...
  5. ncbi Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population
    Yingjian You
    Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1315-21. 2002
    ..This approach provides a high-fidelity in vitro model for evaluation of gene regulation and expression in mouse airway epithelial cells...
  6. pmc A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets
    Akila Jayaraman
    Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17616. 2011
    ..These findings are significant in the context of monitoring the evolution of the currently circulating 2009 H1N1 viruses...
  7. ncbi Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 135:2055-64. 2008
    ..secretion and resorption of proteins into the apical luminal space, a vital step in the elaboration of the trachea's complex tubular network...
  8. ncbi Trachea-derived dpp controls adult midgut homeostasis in Drosophila
    Zhouhua Li
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Cell 24:133-43. 2013
    ..Little is known about the regulation of tissue homeostasis by organ-organ interaction. Here we demonstrate that trachea-derived Decapentaplegic (Dpp), the main bone morphogenetic protein ligand in Drosophila, is essential for adult ..
  9. pmc Multiple roles for Sox2 in the developing and adult mouse trachea
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 136:1899-907. 2009
    The esophagus, trachea and lung develop from the embryonic foregut, yet acquire and maintain distinct tissue phenotypes...
  10. ncbi Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 120:2749-71. 1994
    ..We discuss several possibilities that may account for the apparent functional redundancy observed amongst retinoic acid receptors during embryogenesis...
  11. ncbi Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?
    Luke J Janssen
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002
    ..Also, we will examine some novel ionic mechanisms in the context of Ca(2+) handling and excitation-contraction coupling in ASM...
  12. ncbi Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Science 325:481-3. 2009
    ..virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles...
  13. ncbi Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems
    Anne Uv
    Department of Medical Biochemistry, University of Gothenburg, S 405 30 Gothenburg, Sweden
    Trends Cell Biol 13:301-9. 2003
    ..The formation of the Drosophila respiratory organ (trachea) highlights the basic principles of branch patterning and tube growth that generate a highly elaborate but ..
  14. pmc Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach
    Ying Wang
    Department of Poultry Science, Texas A and M University College Station, TX 77843 2472, USA
    BMC Genomics 10:512. 2009
    ..Avian influenza virus (AIV) not only causes significant economic losses in poultry production, but also is of great concern to human health. The objective of this study was to identify miRNAs associated with AIV infections in chickens...
  15. pmc Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 101:4620-4. 2004
    ..Our data throw light on the mechanisms of generation of pandemic viruses from their avian progenitors and open avenues for cell level-oriented studies on the replication and pathogenicity of influenza virus in humans...
  16. ncbi serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila
    Stefan Luschnig
    Bayreuther Zentrum für Molekulare Biowissenschaften, Department of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    Curr Biol 16:186-94. 2006
    ....
  17. pmc Tube continued: morphogenesis of the Drosophila tracheal system
    Jodi Schottenfeld
    Department of Cell and Developmental Biology, 1214 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 22:633-9. 2010
    ....
  18. ncbi H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
    ..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
  19. pmc Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors
    Thomas Volckaert
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, CO 80206, USA
    Development 140:3731-42. 2013
    ..Interestingly, our data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell differentiation. ..
  20. ncbi Toll-like receptor 7 activation reduces the contractile response of airway smooth muscle
    Anna Karin Ekman
    Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 652:145-51. 2011
    ..Further, they suggest that inhaled Toll-like receptor 7 ligand might be an effective treatment alternative for asthma...
  21. pmc KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels
    Bin Nan Wu
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Br J Pharmacol 142:1105-14. 2004
    ..KMUP-1 (0.01-100 microm) induced concentration-dependent relaxation responses in guinea-pig epithelium-intact trachea precontracted with carbachol...
  22. ncbi Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
    ....
  23. pmc A novel stop codon readthrough mechanism produces functional Headcase protein in Drosophila trachea
    P Steneberg
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187 Umea, Sweden
    EMBO Rep 2:593-7. 2001
    ..By ectopic expression of different Hdc proteins in the trachea, we show that the long Hdc form alone, can function as a potent branching inhibitor whose activity is ..
  24. pmc Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis
    Arjun Guha
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Dev Biol 335:317-26. 2009
    ..We examined the role of matrix metalloproteases (Mmps), and found that reducing Mmp2 activity perturbed disc-trachea association, altered peritracheal distributions of collagen IV and Perlecan, misregulated ASP growth, and ..
  25. pmc Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice
    Michelle A Carey
    Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:126-35. 2007
    ..Airway hyperresponsiveness is a critical feature of asthma. Substantial epidemiologic evidence supports a role for female sex hormones in modulating lung function and airway hyperresponsiveness in humans...
  26. pmc The emergence of shape: notions from the study of the Drosophila tracheal system
    Jordi Casanova
    Institut de Biologia Molecular de Barcelona CSIC, Institut de Recerca Biomèdica, Carrer Josep Samitier 1 5, 08028, Barcelona, Spain
    EMBO Rep 8:335-9. 2007
    ..Rather than providing an objective review of the features of tracheal development, I intend to discuss some selected notions that I think are relevant to the question of shape generation...
  27. ncbi Tracheobronchial foreign body aspiration in children: how reliable are clinical and radiological signs in the diagnosis?
    F T Orji
    Department of Otolaryngology, University of Nigeria Teaching Hospital Enugu, Enugu, Nigeria
    Clin Otolaryngol 35:479-85. 2010
    ..To evaluate the yield of clinical and radiological features in the diagnosis of suspected foreign body aspiration in children and to assess factors associated with delayed diagnosis of foreign body aspiration...
  28. pmc CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants
    Mohammad A Khan
    Veterans Affairs Palo Alto Health Care System Stanford University School of Medicine, CA 94304, USA
    Circ Res 109:1290-301. 2011
    ..While microvascular injury is associated with chronic rejection, the cause of tissue ischemia during alloimmune injury is not yet elucidated...
  29. ncbi The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea
    Ville Pulkkinen
    The Unit for Asthma and Allergy Research, the National Institute of Environmental Medicine and the Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Lung Cell Mol Physiol 303:L956-66. 2012
    ..Isometric responses were assessed in guinea pig trachea (GPT)...
  30. ncbi Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway
    Kang Yun Lee
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa N Rd, Taipei, Taiwan
    Am J Respir Cell Mol Biol 35:407-14. 2006
    ..These data suggest that NE upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma...
  31. pmc Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium
    Idir Akhouayri
    IBDML, UMR 6216 CNRS, Universite Aix Marseille, Marseille, France
    PLoS Pathog 7:e1002319. 2011
    ..e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP) production in the trachea is controlled by ..
  32. pmc Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis
    Ashok N Babu
    Department of Surgery, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 117:3774-85. 2007
    ..After early microvascular loss, neovascularization was eventually observed in the membranous trachea, indicating a reestablishment of graft perfusion in established fibrosis...
  33. pmc Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth
    Jodi Schottenfeld-Roames
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, 1214 BRB II III, Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 14:386-93. 2012
    ..Thus, vesicle trafficking has key roles in making and shaping seamless tubes...
  34. pmc Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome
    Caterina Tiozzo
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Pediatr Res 66:386-90. 2009
    ..which is a disease characterized by a uniform cartilaginous sleeve in place of a normally ribbed cartilagenous trachea. We have studied the cellular and molecular basis of this phenotype in a mouse model of AS (Fgfr2c(+/Delta) mice),..
  35. pmc Tracheal dimensions in human fetuses: an anatomical, digital and statistical study
    Michał Szpinda
    Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum, Karłowicza 24 Street, 85 092 Bydgoszcz, Poland
    Surg Radiol Anat 34:317-23. 2012
    ..The present study was performed to compile normative data for external dimensions of the trachea at varying gestational age.
  36. ncbi Anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles in fetuses measured ex vivo
    - Harjeet
    Department of Anatomy Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Paediatr Anaesth 18:1029-34. 2008
    ..This study is aimed to determine the anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles and their correlation to age and crown rump length (CRL) in fetuses...
  37. pmc Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia
    Anu Sironen
    Biotechnology and Food Research, Animal Genomics, MTT Agrifood Research Finland, Jokioinen, Finland
    Biol Reprod 85:690-701. 2011
    ..Taken together, the data in this study demonstrate that SPEF2 is required for cilia function and identify a new genetic cause of PCD in mice...
  38. pmc Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs
    Nam Soo Joo
    Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
    J Clin Invest 120:3161-6. 2010
    ..These data are a step toward determining whether gland secretory defects contribute to CF airway disease...
  39. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    ..In the trachea, Clara cells give rise to ciliated cells but do not self-renew extensively...
  40. ncbi Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea
    Rainer Schreiber
    Institut fur Physiologie, Universitat Regensburg, Germany
    Cell Physiol Biochem 16:99-108. 2005
    ..Here we show that these metabolites change electrolyte transport by stimulation of P2Y6 receptors in mouse trachea. Immunohistochemistry confirmed luminal and basolateral expression of P2Y6 receptors...
  41. ncbi The plakin Short Stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion
    Seungbok Lee
    Department of Cell Biology and Center for Molecular Neuroscience, C 2210 Medical Center North, Vanderbilt University Medical Center, Nashville, TN 37232 0295, USA
    Development 129:1509-20. 2002
    ..The dominant negative RhoA phenotype suggests that RhoA controls apical surface formation throughout the trachea. We therefore propose that in fusion cells, Shot may function downstream of RhoA to form E-cadherin-associated ..
  42. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In Shh null mutants, we found that the trachea and esophagus do not separate properly and the lungs form a rudimentary sac due to failure of branching and ..
  43. ncbi Drosophila Knickkopf and Retroactive are needed for epithelial tube growth and cuticle differentiation through their specific requirement for chitin filament organization
    Bernard Moussian
    Department of Genetics, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Development 133:163-71. 2006
    ..Uniform tube expansion in the developing Drosophila trachea requires the assembly of a transient intraluminal chitin matrix, where chitin forms a broad cable that expands in ..
  44. pmc Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway
    Patrick Laprise
    Laval University Cancer Research Center, CRCHUQ Hôtel Dieu de Québec, 9 McMahon, Quebec, QC G1R 2J6, Canada
    Curr Biol 20:55-61. 2010
    ..However, the mechanisms of tube size control remain poorly understood. In the Drosophila trachea, tube dimensions are regulated by a luminal extracellular matrix (ECM)...
  45. ncbi boudin is required for septate junction organisation in Drosophila and codes for a diffusible protein of the Ly6 superfamily
    Assia Hijazi
    Université de Toulouse UPS, Centre de Biologie du Developpement, CNRS UMR 5547, Bâtiment 4R3, 118 route de Narbonne, F 31062 Toulouse, France
    Development 136:2199-209. 2009
    ..Our work opens the way for future studies addressing the function of Ly6 proteins using Drosophila as a model system...
  46. pmc A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system
    Amin S Ghabrial
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    PLoS Genet 7:e1002087. 2011
    ....
  47. ncbi In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis
    Carlos Ribeiro
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 2:677-83. 2002
    ..Bnl/FGF signaling affects the formation of dynamic filopodia, possibly controlling cytoskeletal activity and motility as such, and Dpp controls cellular functions allowing branch morphogenesis and outgrowth...
  48. ncbi Genetic control of epithelial tube fusion during Drosophila tracheal development
    C Samakovlis
    Department of Biochemistry, Stanford University School of Medicine, CA 94305, USA
    Development 122:3531-6. 1996
    ..This establishes a simple genetic system to study fusion of epithelial tubes...
  49. pmc Cholinergic chemosensory cells in the trachea regulate breathing
    Gabriela Krasteva
    Institute of Anatomy and Cell Biology and Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen D 35385, Germany
    Proc Natl Acad Sci U S A 108:9478-83. 2011
    ..Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (α-gustducin, phospholipase C(β2)..
  50. pmc Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children
    David K Meyerholz
    Department of Pathology, University of Iowa, Iowa City, 52242, USA
    Am J Respir Crit Care Med 182:1251-61. 2010
    ..Although airway abnormalities are common in patients with cystic fibrosis (CF), it is unknown whether they are all secondary to postnatal infection and inflammation, which characterize the disease...
  51. pmc Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection
    Xinguo Jiang
    Department of Medicine, VA Palo Alto Health Care System Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 121:2336-49. 2011
    ..This study demonstrates that a therapy that enhances vascular integrity during acute rejection may promote graft health and prevent chronic rejection...
  52. ncbi FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system
    Makoto Sato
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Dev Cell 3:195-207. 2002
    ....
  53. ncbi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..We addressed this issue by examining intracellular lumen formation in the Drosophila trachea. The main branches of the Drosophila tracheal system have an extracellular lumen because their cells fold to form ..
  54. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..Failure in septation between the trachea and the esophagus in Nkx2...
  55. ncbi In vivo and in vitro morphometry of the human trachea
    Kirollos Salah Kamel
    Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Clin Anat 22:571-9. 2009
    Most morphometric studies of the human trachea have relied on plain radiographs with their attendant limitations. Reports using computed tomography (CT) have focused on the growing trachea or one particular dimension...
  56. pmc Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells
    Zheng Xing
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA
    Am J Respir Cell Mol Biol 44:24-33. 2011
    ..The findings in this study will further our understanding of host defense mechanisms and the pathogenesis of H9N2 influenza viruses in human respiratory epithelium...
  57. pmc Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    Eric T Domyan
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 138:971-81. 2011
    The mammalian foregut gives rise to the dorsally located esophagus and stomach and the ventrally located trachea and lung...
  58. ncbi Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects
    J Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Canada
    Dev Biol 192:432-45. 1997
    ..Since expression of Hoxa-5 is confined to the mesenchymal component of the developing trachea and lung, the effects observed in epithelial cells may result from a disruption of normal epithelial-mesenchymal ..
  59. ncbi Ultrasound-guided percutaneous dilatational tracheostomy: a safe method to avoid cranial misplacement of the tracheostomy tube
    A Sustic
    Department of Anaesthesiology and ICU, University Hospital Rijeka, Croatia
    Intensive Care Med 26:1379-81. 2000
    ..05) and four (36%) patients had a broken tracheal ring (P = NS). The authors maintain that by using ultrasound-guided PDT cranial misplacement of the tracheostomy tube may be entirely avoided...
  60. pmc Early restriction of peripheral and proximal cell lineages during formation of the lung
    Anne Karina T Perl
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 99:10482-7. 2002
    ..Extensive or complete labeling of peripheral lung, thyroid, and thymic epithelia, but not trachea, bronchi, or gastrointestinal tract occurred when mice were exposed to doxycycline from embryonic day (E) 4...
  61. ncbi Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in Drosophila
    Dominique Förster
    Institute of Zoology, Universitat Zurich, CH 8057 Zurich, Switzerland
    Curr Biol 20:62-8. 2010
    ..These results indicate a critical role of membrane-associated proteins in the process and imply a mechanism that coordinates autonomous behaviors of individual cells within epithelial structures...
  62. ncbi The transmembrane protein TMEM16A is required for normal development of the murine trachea
    Jason R Rock
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
    Dev Biol 321:141-9. 2008
    ..member of an evolutionarily conserved family of predicted transmembrane proteins, is expressed in the developing trachea. We report that all mice homozygous for a null allele of Tmem16a died within one month of birth and exhibited ..
  63. ncbi Basal cells of the human adult airway surface epithelium retain transit-amplifying cell properties
    Rodolphe Hajj
    Institut National de Santé et de Recherche Médicale Unité 514, Centre Hospitalier Universitaire Maison Blanche, Reims, France
    Stem Cells 25:139-48. 2007
    ..These results demonstrate that human adult basal cells are at least airway surface transit-amplifying epithelial cells...
  64. ncbi IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways
    Muhammad Shahidur Rahman
    Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 177:4064-71. 2006
    ..Our results raise the possibility that IL-17A may play a role in allergic asthma by inducing eotaxin-1/CCL11 production...
  65. ncbi Gal4 in the Drosophila female germline
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Mech Dev 78:113-8. 1998
    ..FGF signaling guides tracheal cell migration in the embryo. However, misexpression of branchless in the ovary had no effect on border cell migration. Thus border cells and tracheal cells appear to be guided differently...
  66. ncbi Epithelial mucin genes
    S J Gendler
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA
    Annu Rev Physiol 57:607-34. 1995
    ....
  67. ncbi The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension
    L Glazer
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 5:697-705. 1991
    ..However, the extension of tracheal cell processes leading to the formation of the elaborate tree structure is blocked. The DFGF-R protein may thus participate in receiving spatial cues that guide tracheal cell outgrowth...
  68. pmc Ciliated epithelial cell lifespan in the mouse trachea and lung
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 295:L231-4. 2008
    The steady-state turnover of epithelial cells in the lung and trachea is highly relevant to investigators who are studying endogenous stem cells, manipulating gene expression in vivo, or using viral vectors for gene therapy...
  69. pmc Invasive thyroid cancer: management of the trachea and esophagus
    Daniel L Price
    Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Otolaryngol Clin North Am 41:1155-68, ix-x. 2008
    ..disease may involve critical structures in the central neck, including the recurrent laryngeal nerves, trachea, esophagus, and larynx, requiring surgery extending significantly beyond the thyroid gland...
  70. ncbi Benign esophageal schwannoma compressing the trachea in pregnancy
    Shinjiro Mizuguchi
    Department of Thoracic Surgery, Bell Land General Hospital, Osaka, Japan
    Ann Thorac Surg 85:660-2. 2008
    A rare case of esophageal schwannoma compressing the trachea in pregnancy is presented. A 29-year-old pregnant woman was hospitalized due to severe dyspnea...
  71. pmc Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 312:203-16. 2007
    ..This mechanism is distinct from HSPG functions in morphogen distribution, and is likely a general paradigm for HSPG functions in FGF signaling in Drosophila...
  72. pmc Alcohol exposure alters mouse lung inflammation in response to inhaled dust
    Michael L McCaskill
    Department of Environmental, Agricultural, and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Nutrients 4:695-710. 2012
    ..These data also define alcohol as an important co-exposure agent to consider in the study of inhalation injury responses...
  73. pmc Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation
    Jonas Fuxe
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Am J Pathol 178:2897-909. 2011
    ..The findings also show that the antileakage action of Ang1 requires PDGF-dependent actions of pericytes in maintaining endothelial stability...
  74. ncbi Gene expression analysis after prenatal tracheal ligation in fetal rat as a model of stimulated lung growth
    Carmen Mesas-Burgos
    Astrid Lindgren s Children Hospital, Division for Pediatric Surgery, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Pediatr Surg 44:720-8. 2009
    ..To increase understanding of the biological mechanisms involved in growth stimulation after TL in the fetal lung, we performed Global gene expression analysis using microarray technology...
  75. pmc Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs
    Elad H Kaufman
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA
    J Allergy Clin Immunol 127:462-9. 2011
    ..Respiratory tract viral infections result in asthma exacerbations. Toll-like receptor (TLR) 7 is a receptor for viral single-stranded RNA and is expressed at high levels in the lungs...
  76. ncbi Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function
    Kristina E Ile
    Max Planck Institute for Developmental Biology, Spemannstr 35, 72076 Tubingen, Germany
    Development 139:2535-46. 2012
    ..We now show that wun has an essential tissue-autonomous role in development of the trachea: the catalytic activity of Wun is required to maintain septate junction (SJ) paracellular barrier function, loss ..
  77. ncbi Serum-free culture of mouse tracheal epithelial cells
    R K Kumar
    School of Pathology, University of New South Wales, Sydney, Australia
    Exp Lung Res 23:427-40. 1997
    ..Because the number of cells that can be isolated from the mouse trachea is very small, published techniques are unsuitable for this species...
  78. ncbi Lymphocytic infiltration in the chicken trachea in response to Mycoplasma gallisepticum infection
    J E Gaunson
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    Microbiology 146:1223-9. 2000
    ..There was no significant difference in the number of CD8+ cells in the upper, middle and lower trachea. High numbers of both CD4+ and CD8+ cells were found with variable numbers of TCRalphabeta1+ and TCRalphabeta2+, ..
  79. pmc New methods for monitoring dynamic airway tissue oxygenation and perfusion in experimental and clinical transplantation
    Mohammad A Khan
    VA Palo Alto Stanford University, Palo Alto, CA, USA
    Am J Physiol Lung Cell Mol Physiol 303:L861-9. 2012
    ..circulation, supplied by bronchial and pulmonary artery-derived vessels, normally perfuses the airways from the trachea to the terminal bronchioles...
  80. ncbi Four chamber view plus three-vessel and trachea view for a complete evaluation of the fetal heart during the second trimester
    Antongiulio Del Bianco
    Dipartimento Materno Infantile, Unità Operativa di Ostetricia e Ginecologia 2, Policlinico Univesitario, Foggia, Italy
    J Perinat Med 34:309-12. 2006
    To test the efficacy of a recently introduced ultrasonic scanning plane (three vessel and trachea view -3VTV- plus color flow mapping -3VTVC) on a low-risk population for detection of congenital heart disease (CHD).
  81. ncbi Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy
    Sundeep G Keswani
    The Center for Molecular Fetal Therapy, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Surg 46:33-8. 2011
    Our previous work in a human-fetal trachea xenograft model suggests potential benefits of treating cystic fibrosis in utero. The target for postnatal gene therapy in cystic fibrosis is tracheal submucosal glands (SMGs)...
  82. pmc Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation
    George Gallos
    Dept of Anesthesiology, College of Physicians and Surgeons of Columbia Univ, 650 W 168 St, P and S Box 46, New York, NY, USA
    Am J Physiol Lung Cell Mol Physiol 295:L1040-7. 2008
    ....
  83. ncbi Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors
    Y Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Pharmacol 60:1201-9. 2001
    ..situ hybridization experiments detected alpha7 subunit mRNA in cultured human BEC and AEC and in sections of rat trachea. The binding of radiolabeled alpha-bungarotoxin revealed a few thousand binding sites per cell in cultured human ..
  84. ncbi Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea
    Agung Endro Nugroho
    Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia
    Pak J Pharm Sci 24:427-33. 2011
    ..In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80...
  85. ncbi Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways
    Ofir Bachar
    Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
    Eur J Immunol 34:1196-207. 2004
    ..Costimulation of these receptors results in NF-kappa B- and JNK-mediated transcription of B(1) and B(2) receptor, inducing hyper-responsiveness to bradykinin...
  86. pmc New quantitative patterns of the growing trachea in human fetuses
    Michał Szpinda
    Department of Normal Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland
    Med Sci Monit 18:PH63-70. 2012
    ..Rapid progress in perinatal medicine has resulted in numerous tracheo-bronchial interventions on fetal and neonatal airways. The present study was performed to compile normative data for tracheal dimensions at varying gestational ages...
  87. ncbi Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea
    Peter J Henry
    School of Medicine and Pharmacology, University of Western Australia, Nedlands
    J Pharmacol Exp Ther 314:995-1001. 2005
    ..capacity of SLIGRL to elevate PGE(2) levels and produce relaxation in isolated segments of upper and lower mouse trachea. SLIGRL produced concentration-dependent increases in PGE(2) levels and smooth muscle relaxation, although both ..
  88. ncbi Determination of endotracheal tube size in a perinatal population: an anatomical and experimental study
    Pierre Fayoux
    Service d Oto Rhino Laryngologie ORL et Chirurgie CervicoFaciale Hôpital Huriez, Centre Hospitalier Regional Universitaire CHRU Lille, France
    Anesthesiology 104:954-60. 2006
    This study aimed at correlating anatomical dimensions of the larynx and trachea to age and weight in a prenatal population. Endotracheal tube size determination was then proposed according to these considerations.
  89. ncbi Pathogenicity of a QX strain of infectious bronchitis virus in specific pathogen free and commercial broiler chickens, and evaluation of protection induced by a vaccination programme based on the Ma5 and 4/91 serotypes
    Calogero Terregino
    OIE FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell Universita 10, Legnaro PD, Italy
    Avian Pathol 37:487-93. 2008
    ..This study confirms that vaccination at 1 day old and at 14 days of age using the Ma5 and 4/91 IB vaccines may be instrumental in reducing the economic impact of QX IB virus infections in layer and broiler farms...
  90. pmc Real-time ultrasound-guided percutaneous dilatational tracheostomy: a feasibility study
    Venkatakrishna Rajajee
    Department of Neurosurgery and Neurology, University of Michigan Health System, 3552 Taubman Health Care Center, 1500 E, Medical Center Dr, SPC 5338, Ann Arbor, MI 48109 5338, USA
    Crit Care 15:R67. 2011
    ..Our objective was to demonstrate that PT performed under real-time US guidance with visualization of needle path during tracheal puncture is feasible, including in patients with features that increase the technical difficulty of PT...
  91. pmc The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control
    Kevin S Nelson
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Genetics 185:831-9. 2010
    ..Double- and triple-mutant combinations of Sinuous and Megatrachea with Kune-kune resemble the Kune-kune single mutant, suggesting that Kune-kune has a more central role in septate junction formation than either Sinuous or Megatrachea...
  92. ncbi Percutaneous fetal endoscopic tracheal occlusion (FETO) for severe left-sided congenital diaphragmatic hernia
    J Jani
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Obstet Gynecol 48:910-22. 2005
  93. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    The mammalian respiratory system, consisting of both trachea and lung, initiates from the foregut endoderm. The molecular program that instructs endodermal cells to adopt the respiratory fate is not fully understood...
  94. pmc Prenatal and early postnatal morphogenesis and growth of human laryngotracheal structures
    Pierre Fayoux
    Department of Otolaryngology Head and Neck Surgery, University Hospital of Lille, France
    J Anat 213:86-92. 2008
    ..An anatomical prospective study was based on examination of larynx and trachea from 300 routine autopsies of fetuses and infants, free of malformation and never intubated...
  95. pmc Tracheal Basal cells: a facultative progenitor cell pool
    Brook B Cole
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, Colorado, USA
    Am J Pathol 177:362-76. 2010
    ..In this study, we used gene expression and histomorphometric analysis of the steady-state and naphthalene-injured trachea to evaluate the predictions of this model...
  96. ncbi Tracheal agenesis with unique anatomy
    Nia Fraser
    Department of Paediatric Surgery, Nottingham Hospitals NHS Trust, Queens Medical Centre, NG7 2UH Nottingham, UK
    J Pediatr Surg 40:e7-10. 2005
    ..The possibility of surgical correction rests on early diagnosis, anatomy, birth weight, and associated anomalies. Early recognition is mandatory, but in our case, the low birth weight precluded consideration for reconstructive surgery...
  97. ncbi Late complications of tracheostomy
    Scott K Epstein
    Department of Medicine, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston MA 02135, USA
    Respir Care 50:542-9. 2005
    ..For the most frequent complication, tracheal stenosis, a multidisciplinary approach utilizing bronchoscopy, laser, airway stents, and tracheal surgery is most effective...
  98. ncbi The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells
    Ian Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur J Pharmacol 531:9-12. 2006
    ..05). Therefore, beta2-adrenoceptor agonists can augment spasmogen responses in airway smooth muscle but not via a G-protein/PLC-beta1 mediated mechanism...
  99. ncbi Lung epithelial cells release ATP during ozone exposure: signaling for cell survival
    Shama Ahmad
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Free Radic Biol Med 39:213-26. 2005
    ..Thus, extracellularly released ATP signals to prevent ozone-induced death and supplementation with ATP or its analogs can augment protection, at least in part via Akt and /or ERK signaling pathways and their metabolic effects...
  100. ncbi Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Differentiation 74:422-37. 2006
    ..endoderm, the folding of the endoderm into a foregut tube, and the subsequent separation of the foregut tube into trachea and esophagus...
  101. pmc A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea
    K Iizuka
    First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Br J Pharmacol 128:925-33. 1999
    ..5'-O-(3-thiotriphosphate) (GTPgammaS)-induced contraction in alpha-toxin- or beta-escin-permeabilized rabbit trachea. 2 Although pre-treatment with Y-27632 dose-dependently inhibited GTPgammaS (10 microM)-induced Ca2+ ..

Research Grants64

  1. Pilot Studies of the Effect of Aging on Mucociliary Clearance
    Lawrence E Ostrowski; Fiscal Year: 2013
    ..To test the hypothesis that MCC is reduced in aged mice. Mucociliary clearance will be measured in the trachea and nasopharynx of 3, 6, 12, and 24 month old C57BL/6 mice by tracking the movement of endogenous mucus particles ..
  2. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..In Specific Aim 1, basal cells will be purified from the trachea of normal mice and from mutant mice lacking functional NGFR...
  3. Transcriptional Control of Submucosal Gland Formation and Function
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..that determines both the patterning and differentiation of airway epithelial cells (AECs) lining the developing trachea and bronchi, and the formation of submucosal glands (SMGs) that secrete the majority of fluids, electrolytes, and ..
  4. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..aim 1, we will map the cells that produce these chemokines in the various mucosal tissues (oral cavity, bronchus, trachea, esophagus, gut and the female reproductive tract) by immunohistochemistry and/or in situ hybridization...
  5. Function and Secretion of Bordetella Filamentous Hemagglutinin
    Peggy A Cotter; Fiscal Year: 2013
    ..We have shown that FHA is required for colonization of the lower respiratory tract (specifically the trachea) and that it allows Bordetella to suppress the inflammatory response of its hosts...
  6. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..it serves functional and structural roles, including the support of soft tissue (ear and nose), airway patency (trachea), phonation (larynx), and joint movement (i.e.,TMJ)...
  7. Signal transduction mechanisms to myosin phosphatase
    James T Stull; Fiscal Year: 2013
    ..Gross pathology will be assessed in phasic (ileum) and tonic (trachea) smooth muscles, including histological analyses and expression of contractile and signaling proteins...
  8. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
    ..The in vivo effect of miR-1 on angiogenesis after intranasal delivery was characterized by staining of the trachea from VEGF transgenic mice with CD31...
  9. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2013
    ..The in vivo effect of miR-1 on angiogenesis after intranasal delivery was characterized by staining of the trachea from VEGF transgenic mice with CD31...
  10. Recurrent laryngeal nerve connective tissues as a factor in vocal fold paralysis
    Julie M Barkmeier-Kraemer; Fiscal Year: 2013
    ..onset of UVP in horses suggested that chronic compression to the RLN occurred near the aortic arch or inferior trachea. In fact, recent research has shown that individuals with idiopathic UVP may have damage to the RLN at the level ..
  11. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..of propelling some cells like sperm and protozoa through a liquid environment while other cells like the ciliated trachea of man use the coordinated beating of many cilia to propel a liquid or mucous environment over the surface of the ..
  12. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2013
    ..We will focus on two epithelia, the epididymis, which is at the core of our research program, and the trachea. The epididymis, which connects the testis to the vas deferens, is involved in the maturation and storage of ..
  13. Functional Anatomic Imaging of CF Patients with Early Lung Disease Using microOCT
    Guillermo J Tearney; Fiscal Year: 2013
    ..studies to clearly visualize the structural and functional microanatomy of bronchial epithelial cells and trachea ex vivo...
  14. Tissue Engineering of a Neotrachea
    James E Dennis; Fiscal Year: 2013
    ..The goal of these studies is to develop and fabricate a functional trachea replacement in a rabbit model using tissue engineering principles, and to also fabricate a human-sized neotrachea ..
  15. 3D human lung model to study lung disease and formation of fibrosis
    Joan E Nichols; Fiscal Year: 2013
    ..Both AC whole rat trachea-lung and small sections of AC human lung will be tested for efficacy...
  16. Characterization of CCL28,CXCL14, and CXCL17, three mucosal chemokines
    Albert Zlotnik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mucosal sites include the oral cavity, trachea and bronchi, the digestive system and the female reproductive system...
  17. Respiratory Virus Induced Sensory Neuroplasticity
    Bradley J Undem; Fiscal Year: 2013
    ..electrophysiologically by recording action potential discharge from single A[unreadable] nerve terminals in the trachea, and physiologically using the cough reflex as an outcome...
  18. Actuated, Low-Stress, Endotracheal Tube Cleaner to Improve Neonate Lung Function
    ROGER BROOKS BAGWELL; Fiscal Year: 2013
    ..Public Health Problem: Endotracheal tubes (ETT) are placed in a patient's trachea when they are unable to breathe on their own...
  19. Progenitor Cells in Lung Development and Repair
    Brigid L M Hogan; Fiscal Year: 2013
    ..In Aim 2 we will focus on the adult trachea and main bronchi which has a pseudostratified epithelium, as in a large proportion of the human airways...
  20. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip M Boiselle; Fiscal Year: 2012
    ..Acquired tracheomalacia, a condition defined by excessive expiratory collapse of the trachea due to weakness of the airway walls and/or supporting cartilage, is a relatively common but frequently overlooked ..
  21. Bordetella pathogenesis: an undergraduate research tool
    Louise M Temple; Fiscal Year: 2010
    ..We have developed an explant culture system for ciliated cells from embryonic turkey trachea and purified cilia from adult turkey trachea...
  22. Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tag
    HANNE GRON; Fiscal Year: 2010
    ..Despite annual sales of nearly $1B, BMP-2 has been shown to trigger bone formation at ectopic sites, such as the trachea or esophagus, when not used precisely as directed by its labeling...
  23. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2012
    ..To address these aims, a mouse model will be used. The trachea, bronchi, and lungs with the vagus nerve and vagal sensory ganglia will obtained from mice actively sensitized to ..
  24. Roles of hedgehog signaling in foregut development
    JOHN A KLINGENSMITH; Fiscal Year: 2013
    ..The rostral endodermal foregut tube divides into ventral respiratory (larynx and trachea) and dorsal alimentary (esophagus and stomach) components...
  25. Monoclonal Antibodies and Genetic Elements for Airway Disease
    Frank D McKeon; Fiscal Year: 2010
    ..experiments, we have generated more than 30 monoclonal antibodies specific to ciliated cells of the trachea. Some of these monoclonal antibodies reveal subpopulations of ciliated cells not apparent from histology alone...
  26. rOLE OF TRACHEALESS IN EMBRYONIC TUBE FORMATION
    Deborah J Andrew; Fiscal Year: 2013
    ..We focus on tube formation in the model system of the Drosophila embryonic trachea, a genetically tractable model for learning the molecules and mechanisms underlying the organization of cells ..
  27. Artificial Hand's Seeing Fingers: A New Device for Ingested Foreign Bodies Remova
    VLADIMIR RUBTSOV; Fiscal Year: 2010
    ..hold on the object as it is being removed and as the esophagus relaxes often causes the object to go into the trachea, resulting in death...
  28. Kinematic Modeling of Asymmetric Vocal Fold Vibration
    ROBIN AMY SAMLAN; Fiscal Year: 2011
    ..The inclusion of a trachea and vocal tract in the system allows for additional testing of the effect of airspace on the resulting output ..
  29. Inflammatory and hypoxia responses in neurodegeneration: A novel Drosophila model
    JANIS O'DONNELL; Fiscal Year: 2012
    ..hypotheses regarding mechanisms of the activation of responses and the directed migration of hemocytes and trachea. Cell-specific expression of RNAi and wild type alleles of proposed components of the responses will dissect ..
  30. Propofol in Exhaled Breath: Real-time Detection by Surface Acoustic Wave Sensors
    DONN MICHAEL DENNIS; Fiscal Year: 2012
    ..including: molecular oxygen to prevent hypoxia, carbon dioxide to assure placement of an endotracheal tube in the trachea and adequate ventilation, and anesthetics (e.g...
  31. Miniature Device to Promote Lung Development
    Douglas N Miniati; Fiscal Year: 2011
    ..The most promising in utero therapy developed thus far consists of complete occlusion of the fetal trachea, which has been shown to encourage lung growth...
  32. PCP in vertebrate epithelial tubes
    Jeffrey D Axelrod; Fiscal Year: 2013
    ..genetic and in vitro culture models of PCP in two mouse epithelial tubes: the multiciliated epithelium of the trachea and the renal tubule...
  33. Function of Mipp1 in Regulating Drosophila Trachea Tube Size and Branch Migration
    Yim Ling Cheng; Fiscal Year: 2012
    ..of this proposal is to elucidate the role of multiple inositol polyphosphate phosphatase (Mipp1) in Drosophila trachea development, which is one of the best model systems for studying tubular organogenesis...
  34. The Drosophila expansion Gene Controls Tracheal Tube Diameter
    Lan Jiang; Fiscal Year: 2013
    ..Drosophila trachea provides a premier genetic system to investigate the fundamental mechanisms that regulate tube size...
  35. A mouse model of stem cell deregulation and lung cancer
    JOSEPH LOCKER LOCKER; Fiscal Year: 2010
    ..First apparent in the distal lung buds, the cells spread upward throughout the bronchi and trachea, and eventually formed separate cell populations in the tracheo- bronchial and bronchioloalveolar regions...
  36. Regulation of Airway Protective Behaviors
    Teresa E Pitts; Fiscal Year: 2013
    ..using a multi-electrode array to obtain multiple-spike train data during: a) the selective stimulation of the trachea or pharynx to elicit cough or swallow;b) simultaneous stimulation of the trachea and pharynx to elicit ..
  37. Effects of shear stress on regulation of epithelial permeability
    Venkataramana K Sidhaye; Fiscal Year: 2012
    ..ex vivo isolated mouse trachea. In SA#2 we will define the role for and the mechanisms (TRPV4, L-type channel) of shear-induced calcium flux in ..
  38. Usher Syndrome (USH) genes in Drosophila tubular organ morphogenesis
    SeYeon Chung; Fiscal Year: 2012
    ..In this study, I will focus on the embryonic salivary glands and trachea of Drosophila melanogaster because they are relatively simple tubular organs highly amenable to genetic and ..
  39. Smart Anatomic Recognition System to Guide Emergency Intubation and Resuscitation
    Laura L McCormick; Fiscal Year: 2013
    ..device will reduce failure rates by providing the user with visual instruction of the correct path to the trachea as he places the endotracheal tube...
  40. Role of BMP Antagonism in Craniofacial and Foregut Development
    JOHN A KLINGENSMITH; Fiscal Year: 2010
    ..An important group of foregut defects is tracheoesophageal fistula, where the trachea and esophagus fail to be formed correctly from the early endodermal tube...
  41. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ..to diacetyl (2,3 butadiene), a major component of butter flavoring vapors, results in necrosis of the nasal and trachea, but not the intrapulmonary airways...
  42. Effect of Paramedic Airway Experience on Patient Outcomes
    Henry Wang; Fiscal Year: 2009
    ..Endotracheal intubation (ETI) is the insertion of a plastic tube into the trachea (throat) to assist the breathing of a patient with a critical illness such as cardiopulmonary arrest, heart ..
  43. Pilot Trial of Tubes to Prevent VAP
    Miriam Treggiari; Fiscal Year: 2012
    ..Modification of the material and design of the ETT cuff that is positioned in the trachea, and/or continuous aspiration of subglottic secretions through an extra port positioned between the tube cuff and ..
  44. An Acoustic Respiratory Movement Sensor (ARMS) to Produce and Monitor SIMV in Inf
    Gregory P Heldt; Fiscal Year: 2011
    ..reduce this damage by synchronizing the ventilator so that it can be used non-invasively without a tube in the trachea. The new generation of ventilators will also reduce the amount of effort needed to save the premature infant and ..
  45. LUNG AND AIRWAY AFFERENTS AND THEIR REFLEX ROLE
    JOHN COLERIDGE; Fiscal Year: 1992
    ..Secretion will be assessed by counting tantalum-coated secretory "hillocks" in the upper trachea. 2) To determine the effects of stimulating lung sympathetic afferents of airway secretion, tracheal smooth ..
  46. Bedside monitoring of endotracheal tube position
    HANSEN A MANSY; Fiscal Year: 2013
    ..and will be able to detect bronchial intubation and extubation (tube slippage into the bronchus or out of the trachea, respectively)...
  47. Fenbendazole in Pheasants - Human Food Safety (Tissue Residue) Study
    Ronald W Griffith; Fiscal Year: 2011
    ..pheasants raised on propagation farms can be routinely infected with Heterakis gallinae (cecal worm), Syngamus trachea (gapeworm) and other parasitic worms that are susceptible to fenbendazole treatment...
  48. AIR CONDITIONING BY THE TRACHEA--STIMULI AND MECHANISMS
    Mark Deffebach; Fiscal Year: 1993
    ..As ventilation increases, the trachea becomes a major source of the heat and water required for the conditioning of inspired air...
  49. Coaxial Everting Membrane Catheter Bronchoalveolar Lavag
    William Krause; Fiscal Year: 2006
    ..However, sputum (lung, trachea or oropharyngeal secretions) is often contaminated by saliva, oropharyngeal organisms and squamous cells that are ..
  50. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1993
    ..class of inflammatory mediators are the leukotrienes C4 and D4 (LTC4 and LTD4) which when applied to gut, trachea, and pure cultures of sensory neurons elicit release of the tachykinins substance P (SP) and substance K (SK)...
  51. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2006
    Epithelial cells lining the mammalian trachea form a crucial site in the host defense against airborne microbial pathogens, releasing numerous antimicrobial factors...
  52. A Bioresorbable Splint for Treating Tracheomalacia
    Scott J Hollister; Fiscal Year: 2013
    ..However, current stenting, or other mechanical methods to ensure an open trachea, are associated with failure, morbidity and mortality...
  53. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1993
    ..NNK induces tumors of the lung, trachea and nasal cavity in Syrian golden hamsters; the lung, nasal cavity, liver an pancreas of F344 rats; and the lung ..
  54. MUCOCILIARY TRANSPORT--INHIBITORY NEURAL REGULATION
    DONOVAN YEATES; Fiscal Year: 2003
    ..Ciliary beat frequency, CBF, will be measured in the trachea using heterodyne laser light scattering. SO2 will be used to activate the inhibitory reflex...
  55. AUTONOMIC MUSCARINIC RECEPTOR SIGNALING MECHANISMS
    FRED EHLERT; Fiscal Year: 2000
    ..are to seek out the pharmacological and neurophysiological functions of the M2 muscarinic receptor in the ileum, trachea and urinary bladder...
  56. DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELS
    Timothy Wiedmann; Fiscal Year: 2000
    Mucus occurs throughout the body at epithelial surfaces in the trachea, gall bladder, cervix, eye, bladder, and in saliva as well as along the gastrointestinal tract...
  57. REGULATION OF TRACHEA MUCIN SYNTHESIS AND GLYCOSYLATION
    Joseph Mendicino; Fiscal Year: 1990
    ..mRNA will be isolated from fresh trachea epithelium and cultured mucus secreting epithelial cells...
  58. Optimizing Ventilation Distribution in Injured Lung Using Computational Modeling
    Reza Amini; Fiscal Year: 2013
    ..e. resistance, elastance, peak airway pressure) measured at the trachea with measurements already obtained in dogs from our lab with induced lung injury...
  59. CELLULAR COMMUNICATION IN MORPHOGENESIS
    Mark Krasnow; Fiscal Year: 2003
    ..Krasnow has developed a Drosophila model system for studying the development of trachea, an epithelial derived tissue that delivers oxygen to larval cells...
  60. CF TS TRANSFORMANTS--BIOCHEMICAL AND GENETIC ANALYSIS
    Dieter Gruenert; Fiscal Year: 1992
    ..Clones of transformed CF epithelial cells will be derived from trachea, bronchi, submucosa, and nasal polyps...
  61. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2004
    ..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, ..
  62. REGULATION OF GLYCOPROTEIN BIOSYNTHESIS IN LUNG
    Joseph Mendicino; Fiscal Year: 1991
    ..by mucus secretions which are synthesized in the surface epithelium and in submucosal acinotubular glands in the trachea. The surface epithelium of the tracheobronchial airway is coated with mucus which is constantly removed by the ..
  63. GENOTOXICITY OF BENZO[A]PYRENE DERIVATIVES AND SULFITE
    Gregory Reed; Fiscal Year: 1993
    ..These derivatives, formed in high yield in incubations with either S. typhimurium tester strains or with hamster trachea in organ culture, represent a novel class of reactive intermediates...
  64. ROLE OF ETHANOL IN THE ETIOLOGY OF HEAD & NECK CANCER
    G McCoy; Fiscal Year: 1992
    ..Our studies have shown that ethanol consumption by hamsters results in enhanced liver and target tissue (trachea) metabolism, enhanced post-mitochondrial supernatant-mediated mutagenicity and carcinogenicity (tracheal and ..