Genomes and Genes
Summary: The mucous lining of the NASAL CAVITY, including lining of the NOSTRIL (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.
Publications288 found, 100 shown here
- Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explantsSarah Glorieux
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 136:341-6. 2009..historical PRV strains, single infected cells and plaques of infected cells were quantified at 12 and 36hpi in nasal mucosa explants for seven European PRV strains, isolated in the 1960s (Becker, NIA1), the 1970s (NS374, NIA3, 75V19) ..
- Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutationFrank J Accurso
University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
N Engl J Med 363:1991-2003. 2010..VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro...
- Ataluren (PTC124) induces cystic fibrosis transmembrane conductance regulator protein expression and activity in children with nonsense mutation cystic fibrosisIsabelle Sermet-Gaudelus
Hopital Necker Enfants Malades, Paris, France
Am J Respir Crit Care Med 182:1262-72. 2010..Ataluren (PTC124) is an oral drug that permits ribosomes to readthrough premature stop codons in mRNA to produce functional protein...
- kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patientsFernanda Santos de Oliveira
Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ CEP 21045 900, Brazil
Diagn Microbiol Infect Dis 66:361-5. 2010..Viannia) braziliensis DNA and investigate kDNA signatures of parasite populations present in oral and nasal mucosa lesions from mucosal leishmaniasis patients...
- Nasal-associated lymphoid tissue (NALT): frequency and localization in young childrenA S Debertin
Department Legal Medicine, Medical School of Hannover, Hannover, Germany
Clin Exp Immunol 134:503-7. 2003..Clearly in contrast to rodents human NALT was found disseminated in the nasal mucosa with typical morphological features in 38% of all children, mainly in the middle concha, with similar ..
- The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigensDong Young Kim
Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
J Immunol 186:4253-62. 2011....
- Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosaShimona Gayle
Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
Cell Tissue Res 319:27-36. 2005..P2X5 receptor immunoreactivity was found in the squamous, respiratory and olfactory epithelial cells of the rat nasal mucosa. P2X7 receptor immunoreactivity was also expressed in epithelial cells and colocalised with caspase 9 (an ..
- Incidental maxillary sinus findings in orthodontic patients: a radiographic analysis using cone-beam computed tomography (CBCT)P Pazera
Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland
Orthod Craniofac Res 14:17-24. 2011..To determine the frequency of incidental maxillary sinus findings using cone-beam computed tomography (CBCT) images made for orthodontic purposes...
- A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cellsTomoyuki Masaki
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
Mol Biol Cell 22:2144-56. 2011..The control of this pathway in HNECs may be useful not only for prevention of replication and budding of RSV, but also in therapy for RSV-induced respiratory pathogenesis...
- Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuliThomas Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
Int J Psychophysiol 47:147-58. 2003..g. induced by environmental agents...
- Similarities and differences between smoking-related gene expression in nasal and bronchial epitheliumXiaoling Zhang
Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
Physiol Genomics 41:1-8. 2010..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
- Intranasal instillation of aflatoxin B(1) in rats: bioactivation in the nasal mucosa and neuronal transport to the olfactory bulbP Larsson
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala
Toxicol Sci 55:383-91. 2000..Inhalation of contaminated dust particles may result in high local exposure of the nasal mucosa. The present study was designed to assess bioactivation and toxicity of AFB(1) in the nasal mucosa after ..
- A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunityTatsuya Fukuiwa
The Immunobiology Vaccine Center, Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
Vaccine 26:4849-59. 2008..These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly...
- Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adultsMeri K Tulic
Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
Lancet 363:1689-97. 2004..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults.
- Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airwaysG J Braunstahl
Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Allergy Clin Immunol 107:469-76. 2001..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules...
- Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in miceAna Vila
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Santiago de Compostela, Spain
Eur J Pharm Biopharm 57:123-31. 2004..CS nanoparticles were also labeled with FITC-BSA and their interaction with the rat nasal mucosa examined by confocal laser scanning microcopy (CLSM)...
- Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitisSophie Clement
Department of Pathology and Immunology, University of Geneva, Switzerland
J Infect Dis 192:1023-8. 2005..Intracellular residence may provide a sanctuary for pathogenic bacteria by protecting them from host defense mechanisms and antibiotic treatment during acute, recurrent S. aureus rhinosinusitis...
- Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosaSarah Glorieux
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
PLoS ONE 6:e22160. 2011..Remarkably, interactions of herpesviruses with human mucosa, the locus of infection, remain poorly understood and the underlying mechanisms in stromal infection remain controversial...
- BSE infectivity in the absence of detectable PrP(Sc) accumulation in the tongue and nasal mucosa of terminally diseased cattleAnne Balkema-Buschmann
Friedrich Loeffler Institut, Institute for Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald Insel Riems, Germany
J Gen Virol 92:467-76. 2011..biochemical methods, we were, for the first time, able to detect BSE infectivity in the tongue and in the nasal mucosa of terminally diseased BSE field cases as well as experimentally challenged cattle by transgenic-mouse bioassay...
- Nrf2 expression modifies influenza A entry and replication in nasal epithelial cellsMatthew J Kesic
Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7127, USA
Free Radic Biol Med 51:444-53. 2011..Taken together, these data indicate potential mechanisms by which Nrf2-dependent gene expression regulates susceptibility to influenza in human epithelial cells...
- Follow-up of Staphylococcus aureus nasal carriage after 8 years: redefining the persistent carrier stateM F VandenBergh
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Microbiol 37:3133-40. 1999..aureus nasal carriage is a unique characteristic of a fraction of the population, and the attribute "persistent" should be confined to those individuals for whom serial nasal swab specimen cultures consistently yield S. aureus...
- The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitisS M Keh
Imperial College London, London, UK
Rhinology 49:453-7. 2011..TRPM8 nerve fibres were compared with those expressing other TRP receptors including TRPV1 (capsaicin and heat receptor), and TRPA1 (mechano-cold receptor)...
- Expression of Toll-like receptors in cultured nasal epithelial cellsChih Feng Lin
Department of Otolaryngology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
Acta Otolaryngol 127:395-402. 2007..Considering that the ligand for TLR3 is viral dsRNA, this result is in good accordance with previous reports demonstrating that more differentiated airway epithelial cells have increased resistance to rhinovirus infection...
- Alterations in gene expression of complement components in chronic rhinosinusitisRodney J Schlosser
Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Rhinol Allergy 24:21-5. 2010....
- Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compoundMelvin E Andersen
Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 118:716-31. 2010....
- The rostral ventrolateral medulla mediates the sympathoactivation produced by chemical stimulation of the rat nasal mucosaP F McCulloch
Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
J Physiol 516:471-84. 1999..2. Stimulation of the nasal mucosa increased splanchnic sympathetic nerve discharge (SND), elevated arterial blood pressure (ABP), raised heart ..
- Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigsJ Plevkova
Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Sklabinska 26, Martin 03753, Slovak Republic
Respir Physiol Neurobiol 142:225-35. 2004..We conclude that stimulation of nasal afferent nerves with capsaicin enhances experimentally-induced cough. Our results suggest that afferent inputs from the nose interact with the cough reflex pathways in a manner that enhances cough...
- Activation of olfactory and trigeminal cortical areas following stimulation of the nasal mucosa with low concentrations of S(-)-nicotine vapor--an fMRI study on chemosensory perceptionJessica Albrecht
Department of Neuroradiology, Ludwig Maximilians University Munich, Munich, Germany
Hum Brain Mapp 30:699-710. 2009Applied to the nasal mucosa in low concentrations, nicotine vapor evokes odorous sensations (mediated by the olfactory system) whereas at higher concentrations nicotine vapor additionally produces burning and stinging sensations in the ..
- Effects of nasal mask leak and heated humidification on nasal mucosa in the therapy with nasal continuous positive airway pressure (nCPAP)Yvonne Fischer
Department of Otorhinolaryngology, Laboratory for Sleep Research and Sleep Medicine, University of Ulm, Frauensteige 12, 89075 Ulm, Germany
Sleep Breath 12:353-7. 2008..nCPAP with heated humidifier is able to compensate the dehydration effects induced by nCPAP therapy with NML by increasing the aH at the anterior turbinate area to the levels observed during breathing with nCPAP alone...
- HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitisKen ichi Takano
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
J Histochem Cytochem 53:611-9. 2005..we investigated the expression and function of tight junctions and characterized DCs in the epithelium of nasal mucosa from patients with allergic rhinitis...
- Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitisQ T Dinh
Department of Internal Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
Clin Exp Allergy 35:1443-8. 2005..The present study aimed to explore H1R and H2R expression in complex tissues of the nasal mucosa of perennial allergic rhinitis (PAR).
- Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explantsAnnelies P Vandekerckhove
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
J Gen Virol 91:2019-28. 2010..Finally, this study showed that equine respiratory explants are a valuable and reproducible model to study EHV-1 neurovirulence in vitro, thereby reducing the need for horses as experimental animals...
- Histological study of Trichosomoides nasalis (Nematoda: Trichinelloidea) in the nasal cavities of the murid Arvicanthis niloticus, with associated pathologyM Diagne
Departement de Biologie Animale, Faculte des Sciences, Universite Cheikh Anta Diop, Dakar, Senegal
Parasite 11:351-8. 2004..infected with Trichosomoides nasalis shows that the female worms reside in the epithelial monolayer of the nasal mucosa of the posterior and median cavities. Eggs laid by T...
- Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollenYoshiaki Kitamura
Department of Otolaryngology, University of Tokushima Graduate School, Japan
Acta Otolaryngol 132:434-8. 2012..gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in ..
- Measurement of nasal potential difference in young children with an equivocal sweat test following newborn screening for cystic fibrosisIsabelle Sermet-Gaudelus
CRCM and INSERM U845, Hopital Necker, Faculte de Medecine Necker, Universite Rene Descartes, Paris, France
Thorax 65:539-44. 2010....
- Prevalence of pathologic findings in the maxillary sinus in cone-beam computerized tomographyLutz Ritter
Interdisciplinary Outpatient Department of Oral Surgery and Implantology, Department of Craniomaxillofacial and Plastic Surgery, University of Cologne, Germany
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:634-40. 2011..The aim of this study was to assess the prevalence of pathologic findings in the maxillary sinus by using cone-beam computerized tomography (CBCT)...
- Histological and immunological observations of bacterial and allergic chronic rhinosinusitis in the mouseHeng Wang
Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Am J Rhinol 22:343-8. 2008..The purpose of this study was to elucidate histological and immunologic features of mouse models of bacterial chronic rhinosinusitis (BCRS) and allergic chronic rhinosinusitis (ACRS)...
- Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposureBenjamin C Moeller
Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599 7431, United States
Chem Res Toxicol 24:162-4. 2011The presence of endogenous and exogenous N(2)-hydroxymethyl-dG adducts in DNA from the nasal mucosa and bone marrow of cynomolgus macaques exposed to 1.9 and 6...
- Gene expression for carbonic anhydrase isoenzymes in human nasal mucosaAlice S Tarun
University of California, San Francisco, Medicine, San Francisco, CA, USA
Chem Senses 28:621-9. 2003..CA enzymatic activity has been demonstrated in the human nasal mucosa using enzyme histochemical methods, but no systematic study of nasal mucosal CA isoenzyme gene expression has ..
- Potential role of abnormal ion transport in the pathogenesis of chronic sinusitisKenji Dejima
Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Arch Otolaryngol Head Neck Surg 132:1352-62. 2006..To create well-differentiated cultures of normal and chronic sinusitis paranasal sinus epithelial cells and to compare their electrophysiologic properties...
- Nasal and paranasal sinus anatomy and physiologyFuad M Baroody
Department of Surgery, Section of Otolaryngology Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
Clin Allergy Immunol 19:1-21. 2007
- Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfactionKai Zhao
Bioengineering Department, University of Pennsylvania, RM 120 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
Chem Senses 29:365-79. 2004....
- Nasal resistance and allergic inflammation depend on allergen typeMatteo Gelardi
Dipartimento di Oculistica e Otorinolaringoiatria, Universita di Bari, Bari, Italy
Int Arch Allergy Immunol 141:384-9. 2006..Allergic rhinitis is characterized by inflammatory cell infiltrate and increased nasal airflow resistance...
- Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehydeKun Lu
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, United States
Chem Res Toxicol 24:159-61. 2011..In contrast, exogenous adducts were not detectable in the bone marrow of rats exposed to 15.2 ppm [(13)CD(2)] formaldehyde...
- Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitroStephan Hackenberg
Department of Oto Rhino Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
Toxicol In Vitro 25:657-63. 2011..The current study focused on the cyto- and genotoxicity of ZnO-NPs in comparison to ZnO powder in primary human nasal mucosa cells cultured in the air-liquid interface...
- Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosaG J Braunstahl
Department of Otorhinolaryngology, Erasmus University Medical Center Rotterdam, The Netherlands
Am J Respir Crit Care Med 164:858-65. 2001..05) in allergic rhinitis patients after SBP. In the nasal mucosa, the numbers of MC(C) and MC(TC) cells decreased significantly, whereas the numbers of [BB1(+)] cells increased ..
- Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenzaIlona Jaspers
Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
Am J Respir Cell Mol Biol 43:368-75. 2010....
- Topographical differences in distribution and responsiveness of trigeminal sensitivity within the human nasal mucosaThomas Meusel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School Technische Universität Dresden, Dresden, Germany
Pain 151:516-21. 2010..These findings suggest that the presence of topographical and chemosensory differences in the responsiveness of the nasal mucosa to irritants.
- Anatomical mapping of human herpesvirus reservoirs of infectionTiansheng Chen
Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
Mod Pathol 19:726-37. 2006..CMV was detected in three cases, most commonly in nasal mucosa, trachea, thyroid, intestine, and liver...
- Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitisR U Pawankar
Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
Am J Respir Crit Care Med 152:2059-67. 1995..The present study was designed to investigate the expression of IL-13 gene in the epithelial compartment of the nasal mucosa of patients with perennial allergic rhinitis (PAR) to house dust mite, comparing it with that in the nasal ..
- Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polypsZ Liu
Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Allergy 62:999-1006. 2007....
- Structural and functional differences between putative mucosal inductive sites of the ratAdrian W Zuercher
Department of Biology, University of Pennsylvania, Philadelphia, USA
Eur J Immunol 32:3191-6. 2002..These data reveal profound qualitative differences between these three mucosal sites, and strongly suggest that BALT is not a mucosal inductive site for reovirus-specific immune responses in the rat...
- Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccineTakashi Hirano
Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
Immunol Lett 107:131-9. 2006..These kinetic antibody patterns and cellular responses may provide useful information regarding to effective mucosal vaccines against NTHi infections...
- Evaluation of MRSA Select, a new chromogenic medium for the detection of nasal carriage of methicillin-resistant Staphylococcus aureusSana Ben Nsira
Service de Microbiologie, Hôpital Côte de Nacre, Universite de Caen, 14033 Caen Cedex, France
Int J Antimicrob Agents 27:561-4. 2006..By contrast, on the single criterion of the colour of colonies for MRSA positivity, the specificity and sensitivity of MRSA Select were high (99.8% and 99%, respectively)...
- Forkhead box P3+ T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposisT Liu
Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
Clin Exp Immunol 163:59-64. 2011..The present study aims to examine the regulatory T cells (T(reg) ) in nasal mucosa of patients with allergic rhinitis (AR) and nasal polyposis (NP)...
- Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehydeFanxue Meng
US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA
Regul Toxicol Pharmacol 57:274-83. 2010This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR)...
- Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosaG Kobal
Institute of Pharmacology and Toxicology, University Erlangen Nurnberg, F R G
Electroencephalogr Clin Neurophysiol 71:241-50. 1988..Responses to the mixture of carbon dioxide and vanillin appeared significantly earlier (50-150 msec) than responses to either substance alone...
- The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cellsFiona M Roche
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
Microbiology 149:2759-67. 2003..These results suggest that SasG, Pls and AAP bind to the same as-yet-unidentified receptor on the surface of nasal epithelial cells. In addition, expression of SasG, like Pls, reduced adherence of S. aureus to fibronectin and fibrinogen...
- Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating densityAna Vila
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostel, 15782 Santiago de Compostela, Spain
J Control Release 98:231-44. 2004..of Poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) nano- and microparticles on their transport across the nasal mucosa. Particles were made of PLA-PEG copolymers of two different molecular weights (Mw: 37 and 28 kDa) and also PLA ..
- Localization of nitric oxide synthase in human nasal mucosa with nasal allergyH Kawamoto
Department of Otolaryngology, Hiroshima University School of Medicine, Japan
Acta Otolaryngol Suppl 539:65-70. 1998..To investigate the expression of NOS in human nasal mucosa, histochemical staining for NADPH diaphorase and immunohistochemical staining for NOS isoforms were carried out ..
- Iota-Carrageenan is a potent inhibitor of rhinovirus infectionAndreas Grassauer
Marinomed Biotechnologie GmbH, Veterinaerplatz 1 HA, A 1210 Vienna, Austria
Virol J 5:107. 2008..In addition, HRVs are implicated in the worsening of COPD and asthma, as well as the loss of lung transplants. Despite significant efforts, no anti-viral agent is approved for the prevention or treatment of HRV-infection...
- Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitisPooja Takhar
The Randall Division, King s College London, London, United Kingdom
J Immunol 174:5024-32. 2005..We have investigated the provenance of these B cells in the nasal mucosa in allergic rhinitis...
- In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tractSarah Glorieux
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
J Virol Methods 142:105-12. 2007..Molecular and cellular aspects of the interactions of respiratory viruses with the respiratory nasal mucosa are largely unknown. In order to be able to study those interactions in depth, an in vitro model was set up...
- Nasal-associated lymphoid tissue is a mucosal inductive site for virus-specific humoral and cellular immune responsesAdrian W Zuercher
Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 168:1796-803. 2002..Together these data provide direct evidence that NALT is a mucosal inductive site for humoral and cellular immune responses in the upper respiratory tract...
- Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosisBob Lubamba
Department of Clinical Chemistry, Universite Catholique de Louvain, Brussels, Belgium
Am J Respir Crit Care Med 177:506-15. 2008..The effect was observed in vitro and in the presence of doses roughly 300 times larger than those commonly used for treating erectile dysfunction...
- Nasal carriage of Staphylococcus aureus among healthy adultsChong Seng Choi
Department of Clinical Laboratory Sciences, Universiti Putra Malaysia, Selangor, Malaysia
J Microbiol Immunol Infect 39:458-64. 2006..aureus (MRSA), the prevalence of S. aureus nasal colonization in a population of healthy adults was determined. Factors associated with S. aureus nasal carriage and antibiotic sensitivity patterns of the isolates were also analyzed...
- Mechanical endonasal dacryocystorhinostomy with mucosal flapsA Tsirbas
Department of Ophthalmology, Flinders Medical Centre and Queen Elizabeth Hospital, Adelaide, South Australia
Br J Ophthalmol 87:43-7. 2003..This is a new technique that involves creation of a large rhinostomy and mucosal flaps. The study involved a prospective non-randomised interventional case series with short perioperative follow up...
- Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitisDavid D Tieu
Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill 60607, USA
J Allergy Clin Immunol 125:667-75. 2010..Decreased epithelial expression of mRNA for S100A7 (psoriasin) and S100A8/A9 (calprotectin) has been reported in patients with chronic rhinosinusitis (CRS)...
- Development of rhinovirus study model using organ culture of turbinate mucosaYong Ju Jang
Department of Otolaryngolgy, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2dong, Songpa Gu, Seoul 138 736, South Korea
J Virol Methods 125:41-7. 2005..Our results indicate that the air-liquid interface organ culture of turbinate mucosa could serve as an acceptable in vitro model for studying RV infection...
- Distribution of respiratory mucin proteins in human nasal mucosaDavid A Groneberg
Department of Medicine, Charite School of Medicine, Humboldt University, Charite Campus Virchow, BMFZ Forum 4 Fach 40, Augustenburger Platz 1, D 13353 Berlin, Germany
Laryngoscope 113:520-4. 2003..We examined the cellular expression and distribution of two major respiratory mucus-forming glycoproteins, MUC5AC and MUC5B, in normal human nasal tissues...
- The nasal dendritic cell-targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumoniaKosuke Kataoka
Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8504, Japan
Infect Immun 79:2819-28. 2011..elevated numbers of CD8(+) and CD11b(+) DCs and interleukin 2 (IL-2)- and IL-4-producing CD4(+) T cells in the nasal mucosa-associated lymphoid tissues (NALT) and cervical lymph nodes (CLNs)...
- Rhinovirus infection-induced alteration of tight junction and adherens junction components in human nasal epithelial cellsNam Kyung Yeo
Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea
Laryngoscope 120:346-52. 2010..The objective of this study was to investigate changes in the components of TJs (ZO-1, occluding, and claudin-1) and AJs (E-cadherin) after RV infection in cultured nasal epithelial cells...
- Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthmaT Sekigawa
Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan
Clin Exp Allergy 39:972-81. 2009..The lower airway lesion and the nasal polyp in AIA are postulated to have common pathogenic features involving aspirin sensitivity that would be reflected in the gene expression profile of AIA polyps...
- Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitisHeather A Coker
The Randall Division of Cell and Molecular Biophysics, King s College London, London
J Allergy Clin Immunol 116:445-52. 2005IgE antibody-producing B cells are enriched in the nasal mucosa in patients with allergic rhinitis because of local class switching to IgE. The expressed IgE VH genes also undergo somatic hypermutation in situ to generate clonal families...
- Transport of intranasally instilled fine Fe2O3 particles into the brain: micro-distribution, chemical states, and histopathological observationBing Wang
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
Biol Trace Elem Res 118:233-43. 2007..The further histopathological observation showed that the neuron fatty degeneration occurred in the CA3 area of hippocampus. Such results imply an adverse impact of inhalation of fine Fe2O3 particles on CNS...
- Transport of nanoparticles across the rat nasal mucosaJ Brooking
Institute of Pharmaceutical Sciences, University of Nottingham, Boots Science Building, Science Road, University Park, Nottingham, NG7 2RD, UK
J Drug Target 9:267-79. 2001The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings...
- Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cellsHenry Yim Wu
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:6038-50. 2008..Our results demonstrate that nasal anti-CD3 induces CD4(+)CD25(-)LAP(+) regulatory T cells that suppress lupus in mice and that it is associated with down-regulation of T cell help for autoantibody production...
- Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosaS N Snow
Division of Plastic Surgery, Section of Mohs Surgery, Department of Surgery, University of Wisconsin-Madison, School of Medicine, Madison, Wisconsin 53705, USA
Dermatol Surg 27:165-70. 2001..Mucosal MCC is rare and may occur as a long-term sequelae after radiation therapy to the skin...
- Correlation between epithelial toxicity and surfactant structure as derived from the effects of polyethyleneoxide surfactants on caco-2 cell monolayers and pig nasal mucosaKatarina Ekelund
Department of Pharmacy, Uppsala University, Box 580, SE 751 23 Uppsala, Sweden
J Pharm Sci 94:730-44. 2005The cell toxic effects of nonionic surfactants were investigated by means of two in vitro models, namely pig nasal mucosa mounted in horizontal Ussing chambers, and Caco-2 cell monolayers...
- Blue nevus of the nasal mucosaSimonetta Piana
Virchows Arch 446:342-3. 2005
- Expression and localization of steroid receptors in human nasal mucosaHideaki Shirasaki
Department of Otolaryngology, Sapporo Medical School, Sapporo, 060 8543, Japan
Acta Otolaryngol 124:958-963. 2004To investigate the expression of glucocorticoid receptor (GR), oestrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) in nasal mucosa.
- Neuroendocrine cells in the nasal mucosa - preliminary reportAndrzej Sieskiewicz
Department of Otolaryngology, Head and Neck Surgery, Medical University of Białystok, Poland
Folia Histochem Cytobiol 45:123-7. 2007..The aim of the study was the quantitative and morphometric assessment of NC in nasal mucosa in some pathological states.
- Massive apoptosis erodes nasal mucosa of cocaine abusersMatteo Trimarchi
Department of Otorhinolaryngology, San Raffaele Hospital and Vita Salute University San Raffaele, Milano, Italy
Am J Rhinol 20:160-4. 2006..A threatening occurrence in some cocaine abusers is the progressive destruction of nasal structures (cocaine-induced midline destructive lesions [CIMDL]) that may end in a highly severe disease...
- Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challengeNathalie Etchart
Lung Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
Eur J Immunol 36:1136-44. 2006..These data show that immunisation with iRSV and OMV maintains a NALT RSV-specific plasma cell population and generates an efficient protective immune response following RSV infection...
- T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosaJana Goldmann
Department of Experimental Neuroimmunology, Charite, Universitatsmedizin, Berlin, Germany
J Leukoc Biol 80:797-801. 2006..Irrespective of the injection site, we demonstrate their passage through the cribroid plate, appearance in the nasal mucosa, and specific accumulation in one of the cervical lymph nodes.
- Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosaT N Dear
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO J 10:2813-9. 1991..Therefore, the olfactory mucosa may possess diverse, functionally-distinct odorant-binding proteins which recognize and bind separate classes of odorants...
- Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survivalJ Mullol
IDIBAPS, Rhinology Unit, ENT Department, Hospital Clinic, Deparmtent of Medicine, Universitat de Barcelona, Barcelona, Catalonia, Spain
Clin Exp Allergy 36:52-8. 2006..Second-generation antihistamines are H(1) receptor antagonists and may have additional anti-inflammatory effects...
- Induction of airway remodeling of nasal mucosa by repetitive allergen challenge in a murine model of allergic rhinitisYune Sung Lim
Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
Ann Allergy Asthma Immunol 98:22-31. 2007..Although many studies regarding airway remodeling in asthma have been reported, only a few studies have investigated airway remodeling in allergic rhinitis...
- Topographical differences in the trigeminal sensitivity of the human nasal mucosaMandy Scheibe
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Neuroreport 17:1417-20. 2006..These results are compatible with the idea that the trigeminal system acts as a sentinel of the human airways...
- Production of IgA monoclonal antibody against Shiga toxin binding subunits employing nasal-associated lymphoid tissueY Imai
Department of Microbiology and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
J Immunol Methods 302:125-35. 2005....
- Comparison of three chromogenic media and enrichment broth media for the detection of methicillin-resistant Staphylococcus aureus from mucocutaneous screening specimens : Comparison of MRSA chromogenic mediaC Nonhoff
Laboratoire de Référence MRSA Staphylocoques, Service de Microbiologie, Hopital Erasme, Bruxelles, Belgium
Eur J Clin Microbiol Infect Dis 28:363-9. 2009..In conclusion, all media showed equivalent sensitivities after 18 h of incubation and performed better when enriched before inoculation. MRSA-Screen was more sensitive but less specific than the two other media after 42 h of incubation...
- Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypesFrode L Jahnsen
LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
Am J Respir Cell Mol Biol 30:31-7. 2004..How these two cell populations regulate the tone of the local adaptive immune system should be the focus of further studies...
- [Expression of thymic stromal lymphopoietin in nasal mucosa of a mouse model with allergic rhinitis]Meili Xu
Department of ICU, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:794-5, 799. 2009To investigate the expression of thymic stromal lymphopoietin (TSLP) in the nasal mucosa of mouse with allergic rhinitis.
- A morphologic and immunohistochemical study of nasal mucosa in leatherworkersAnnarita Palomba
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Am J Rhinol 22:356-60. 2008..The purpose of this study was to investigate the histological changes and modifications in the phenotype of epithelial cells in nasal mucosa of leather workers.
- Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccineLaura L Hammitt
Section of Infectious Diseases, Department of Pediatrics, University of Colorado Denver, Denver, CO, United States
Vaccine 27:7359-66. 2009..PBMCs from subjects receiving CAIV showed a higher proportion of functional, tissue-tropic T-cells (CD4+CD69+CD18+MIP1alpha+) specific for homotypic and heterosubtypic strains of influenza by flow cytometry...
- Human nasal mucosa contains tissue-resident immunologically responsive mesenchymal stromal cellsMark Jakob
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Germany
Stem Cells Dev 19:635-44. 2010..Here, we report for the first time on the isolation and characterization of multipotent nasal mucosa-derived mesenchymal stromal cells (nm-MSC)...
- Neuroendocrine cells of nasal mucosa are a cellular source of brain-derived neurotrophic factorL Jornot
Division of Pulmonary Medicine, Dept of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
Eur Respir J 32:769-74. 2008..Therefore, airway mucosa might contribute to neurogenic inflammation through increased secretion of brain-derived neurotrophic factor by neuroendocrine cells under inflammatory conditions...
- Regression of polypoid nasal mucosa after systemic corticosteroid therapy: a proteomics studyArmin Farajzadeh Deroee
Department of Otorhinolaryngology and Head and Neck Surgery, Ernst Moritz Arndt University, Greifswald, Germany
Am J Rhinol Allergy 23:480-5. 2009..Identifying and comparing the protein profile of chronic rhinosinusitis (CRS) with NP before and after treatment with GCs can help to clarify NP pathogenesis and mechanisms of corticosteroid effects on NP...
- Nasal potential difference measurements in patients with atypical cystic fibrosisM Wilschanski
Dept of Pediatrics, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel
Eur Respir J 17:1208-15. 2001..This calculation may assist in the diagnostic work-up of patients whose diagnosis is questionable...
- Differential proteomic analysis of nasal polyps, chronic sinusitis, and normal nasal mucosa tissuesWu Min-man
Department of Otorhinolaryngology, The First Affiliated Hospital of Yunnan College of Traditional Chinese Medicine, Kunming, China
Otolaryngol Head Neck Surg 141:364-8. 2009To compare protein expression in nasal polyps, chronic sinusitis, and normal nasal mucosa tissues using proteomic technology.
- Uptake of cobalt from the nasal mucosa into the brain via olfactory pathways in ratsEva Persson
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, BMC, Box 573, S 751 23 Uppsala, Sweden
Toxicol Lett 145:19-27. 2003..We consider that the olfactory route of entry of cobalt into the brain may be important and should be taken into account when risk assessments are performed concerning occupational inhalation of this metal...
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2009..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2010..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
- Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal MucosMaureen Donovan; Fiscal Year: 2009..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
- Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal MucosMaureen D Donovan; Fiscal Year: 2010..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
- EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASELawrence Schwartz; Fiscal Year: 2001..tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
- METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESStephen Hecht; Fiscal Year: 2003..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
- Human CYP2A and respiratory tract xenobiotic toxicityXinxin Ding; Fiscal Year: 2007..respiratory tract and is much more abundant than CYP2A6, the other functional member of the CYP2A subfamily, in nasal mucosa and lung; (b) heterologously expressed CYP2A13 is highly active in the metabolic activation of several ..
- Proteomics of Staphylococcus aureus nasal carriageAlexander Cole; Fiscal Year: 2003The human nasal mucosa is an accessible and clinically important model for the study of microbial interactions with host defenses...
- Development of a Mouse Trigeminal Pain ModelANDREW RUSSO; Fiscal Year: 2007..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa. An advantage of this route is that it should deliver virus to the entire trigeminal nerve, including the ..
- Chlipoplex Nanoparticle Prophylactics for RSV InfectionShyam Mohapatra; Fiscal Year: 2004..hypothesis that chlipoplexes will deliver effectively the pDNAs without any significant adverse effects in the nasal mucosa and provide significant protection against viral infections...
- FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAYIgor Kratskin; Fiscal Year: 2003..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
- R01-Williajm - Double-Blind Placebo-Controlled trial of Nicotine Nasal Spray as aJill M Williams; Fiscal Year: 2010..Nicotine Nasal Spray (NNS) differs from other forms of NRT in that nicotine is absorbed rapidly through the nasal mucosa and produces physiological effects that are expected to speed relief of withdrawal and craving...
- Nasal carriage of S. aureus: host-pathogen interactionsAlexander Cole; Fiscal Year: 2007..We hypothesize that 1) the expression of lipocalin-1 is dysregulated in the nasal mucosa of SA carriers, contributing to the progressive colonization of SA, 2) correcting the lipocalin-1 deficiency ..