nasal mucosa

Summary

Summary: The mucous lining of the NASAL CAVITY, including lining of the NOSTRIL (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.

Top Publications

  1. doi Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Microbiol 136:341-6. 2009
  2. pmc Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    Frank J Accurso
    University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
    N Engl J Med 363:1991-2003. 2010
  3. ncbi Ataluren (PTC124) induces cystic fibrosis transmembrane conductance regulator protein expression and activity in children with nonsense mutation cystic fibrosis
    Isabelle Sermet-Gaudelus
    Hopital Necker Enfants Malades, Paris, France
    Am J Respir Crit Care Med 182:1262-72. 2010
  4. doi kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patients
    Fernanda Santos de Oliveira
    Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ CEP 21045 900, Brazil
    Diagn Microbiol Infect Dis 66:361-5. 2010
  5. pmc Nasal-associated lymphoid tissue (NALT): frequency and localization in young children
    A S Debertin
    Department Legal Medicine, Medical School of Hannover, Hannover, Germany
    Clin Exp Immunol 134:503-7. 2003
  6. doi The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens
    Dong Young Kim
    Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Immunol 186:4253-62. 2011
  7. ncbi Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa
    Shimona Gayle
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Cell Tissue Res 319:27-36. 2005
  8. doi Incidental maxillary sinus findings in orthodontic patients: a radiographic analysis using cone-beam computed tomography (CBCT)
    P Pazera
    Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland
    Orthod Craniofac Res 14:17-24. 2011
  9. pmc A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells
    Tomoyuki Masaki
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mol Biol Cell 22:2144-56. 2011
  10. ncbi Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuli
    Thomas Hummel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
    Int J Psychophysiol 47:147-58. 2003

Detail Information

Publications288 found, 100 shown here

  1. doi Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Microbiol 136:341-6. 2009
    ..historical PRV strains, single infected cells and plaques of infected cells were quantified at 12 and 36hpi in nasal mucosa explants for seven European PRV strains, isolated in the 1960s (Becker, NIA1), the 1970s (NS374, NIA3, 75V19) ..
  2. pmc Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    Frank J Accurso
    University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
    N Engl J Med 363:1991-2003. 2010
    ..VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro...
  3. ncbi Ataluren (PTC124) induces cystic fibrosis transmembrane conductance regulator protein expression and activity in children with nonsense mutation cystic fibrosis
    Isabelle Sermet-Gaudelus
    Hopital Necker Enfants Malades, Paris, France
    Am J Respir Crit Care Med 182:1262-72. 2010
    ..Ataluren (PTC124) is an oral drug that permits ribosomes to readthrough premature stop codons in mRNA to produce functional protein...
  4. doi kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patients
    Fernanda Santos de Oliveira
    Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ CEP 21045 900, Brazil
    Diagn Microbiol Infect Dis 66:361-5. 2010
    ..Viannia) braziliensis DNA and investigate kDNA signatures of parasite populations present in oral and nasal mucosa lesions from mucosal leishmaniasis patients...
  5. pmc Nasal-associated lymphoid tissue (NALT): frequency and localization in young children
    A S Debertin
    Department Legal Medicine, Medical School of Hannover, Hannover, Germany
    Clin Exp Immunol 134:503-7. 2003
    ..Clearly in contrast to rodents human NALT was found disseminated in the nasal mucosa with typical morphological features in 38% of all children, mainly in the middle concha, with similar ..
  6. doi The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens
    Dong Young Kim
    Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Immunol 186:4253-62. 2011
    ....
  7. ncbi Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa
    Shimona Gayle
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Cell Tissue Res 319:27-36. 2005
    ..P2X5 receptor immunoreactivity was found in the squamous, respiratory and olfactory epithelial cells of the rat nasal mucosa. P2X7 receptor immunoreactivity was also expressed in epithelial cells and colocalised with caspase 9 (an ..
  8. doi Incidental maxillary sinus findings in orthodontic patients: a radiographic analysis using cone-beam computed tomography (CBCT)
    P Pazera
    Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland
    Orthod Craniofac Res 14:17-24. 2011
    ..To determine the frequency of incidental maxillary sinus findings using cone-beam computed tomography (CBCT) images made for orthodontic purposes...
  9. pmc A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells
    Tomoyuki Masaki
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mol Biol Cell 22:2144-56. 2011
    ..The control of this pathway in HNECs may be useful not only for prevention of replication and budding of RSV, but also in therapy for RSV-induced respiratory pathogenesis...
  10. ncbi Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuli
    Thomas Hummel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
    Int J Psychophysiol 47:147-58. 2003
    ..g. induced by environmental agents...
  11. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
    ..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
  12. ncbi Intranasal instillation of aflatoxin B(1) in rats: bioactivation in the nasal mucosa and neuronal transport to the olfactory bulb
    P Larsson
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala
    Toxicol Sci 55:383-91. 2000
    ..Inhalation of contaminated dust particles may result in high local exposure of the nasal mucosa. The present study was designed to assess bioactivation and toxicity of AFB(1) in the nasal mucosa after ..
  13. pmc A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity
    Tatsuya Fukuiwa
    The Immunobiology Vaccine Center, Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Vaccine 26:4849-59. 2008
    ..These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly...
  14. ncbi Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults
    Meri K Tulic
    Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
    Lancet 363:1689-97. 2004
    ..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults.
  15. ncbi Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways
    G J Braunstahl
    Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Allergy Clin Immunol 107:469-76. 2001
    ..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules...
  16. ncbi Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice
    Ana Vila
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Santiago de Compostela, Spain
    Eur J Pharm Biopharm 57:123-31. 2004
    ..CS nanoparticles were also labeled with FITC-BSA and their interaction with the rat nasal mucosa examined by confocal laser scanning microcopy (CLSM)...
  17. ncbi Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis
    Sophie Clement
    Department of Pathology and Immunology, University of Geneva, Switzerland
    J Infect Dis 192:1023-8. 2005
    ..Intracellular residence may provide a sanctuary for pathogenic bacteria by protecting them from host defense mechanisms and antibiotic treatment during acute, recurrent S. aureus rhinosinusitis...
  18. pmc Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 6:e22160. 2011
    ..Remarkably, interactions of herpesviruses with human mucosa, the locus of infection, remain poorly understood and the underlying mechanisms in stromal infection remain controversial...
  19. doi BSE infectivity in the absence of detectable PrP(Sc) accumulation in the tongue and nasal mucosa of terminally diseased cattle
    Anne Balkema-Buschmann
    Friedrich Loeffler Institut, Institute for Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald Insel Riems, Germany
    J Gen Virol 92:467-76. 2011
    ..biochemical methods, we were, for the first time, able to detect BSE infectivity in the tongue and in the nasal mucosa of terminally diseased BSE field cases as well as experimentally challenged cattle by transgenic-mouse bioassay...
  20. pmc Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells
    Matthew J Kesic
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7127, USA
    Free Radic Biol Med 51:444-53. 2011
    ..Taken together, these data indicate potential mechanisms by which Nrf2-dependent gene expression regulates susceptibility to influenza in human epithelial cells...
  21. pmc Follow-up of Staphylococcus aureus nasal carriage after 8 years: redefining the persistent carrier state
    M F VandenBergh
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Microbiol 37:3133-40. 1999
    ..aureus nasal carriage is a unique characteristic of a fraction of the population, and the attribute "persistent" should be confined to those individuals for whom serial nasal swab specimen cultures consistently yield S. aureus...
  22. doi The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitis
    S M Keh
    Imperial College London, London, UK
    Rhinology 49:453-7. 2011
    ..TRPM8 nerve fibres were compared with those expressing other TRP receptors including TRPV1 (capsaicin and heat receptor), and TRPA1 (mechano-cold receptor)...
  23. ncbi Expression of Toll-like receptors in cultured nasal epithelial cells
    Chih Feng Lin
    Department of Otolaryngology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    Acta Otolaryngol 127:395-402. 2007
    ..Considering that the ligand for TLR3 is viral dsRNA, this result is in good accordance with previous reports demonstrating that more differentiated airway epithelial cells have increased resistance to rhinovirus infection...
  24. doi Alterations in gene expression of complement components in chronic rhinosinusitis
    Rodney J Schlosser
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Rhinol Allergy 24:21-5. 2010
    ....
  25. ncbi Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound
    Melvin E Andersen
    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 118:716-31. 2010
    ....
  26. pmc The rostral ventrolateral medulla mediates the sympathoactivation produced by chemical stimulation of the rat nasal mucosa
    P F McCulloch
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Physiol 516:471-84. 1999
    ..2. Stimulation of the nasal mucosa increased splanchnic sympathetic nerve discharge (SND), elevated arterial blood pressure (ABP), raised heart ..
  27. ncbi Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigs
    J Plevkova
    Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Sklabinska 26, Martin 03753, Slovak Republic
    Respir Physiol Neurobiol 142:225-35. 2004
    ..We conclude that stimulation of nasal afferent nerves with capsaicin enhances experimentally-induced cough. Our results suggest that afferent inputs from the nose interact with the cough reflex pathways in a manner that enhances cough...
  28. doi Activation of olfactory and trigeminal cortical areas following stimulation of the nasal mucosa with low concentrations of S(-)-nicotine vapor--an fMRI study on chemosensory perception
    Jessica Albrecht
    Department of Neuroradiology, Ludwig Maximilians University Munich, Munich, Germany
    Hum Brain Mapp 30:699-710. 2009
    Applied to the nasal mucosa in low concentrations, nicotine vapor evokes odorous sensations (mediated by the olfactory system) whereas at higher concentrations nicotine vapor additionally produces burning and stinging sensations in the ..
  29. doi Effects of nasal mask leak and heated humidification on nasal mucosa in the therapy with nasal continuous positive airway pressure (nCPAP)
    Yvonne Fischer
    Department of Otorhinolaryngology, Laboratory for Sleep Research and Sleep Medicine, University of Ulm, Frauensteige 12, 89075 Ulm, Germany
    Sleep Breath 12:353-7. 2008
    ..nCPAP with heated humidifier is able to compensate the dehydration effects induced by nCPAP therapy with NML by increasing the aH at the anterior turbinate area to the levels observed during breathing with nCPAP alone...
  30. ncbi HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis
    Ken ichi Takano
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Histochem Cytochem 53:611-9. 2005
    ..we investigated the expression and function of tight junctions and characterized DCs in the epithelium of nasal mucosa from patients with allergic rhinitis...
  31. ncbi Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis
    Q T Dinh
    Department of Internal Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Exp Allergy 35:1443-8. 2005
    ..The present study aimed to explore H1R and H2R expression in complex tissues of the nasal mucosa of perennial allergic rhinitis (PAR).
  32. doi Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explants
    Annelies P Vandekerckhove
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Gen Virol 91:2019-28. 2010
    ..Finally, this study showed that equine respiratory explants are a valuable and reproducible model to study EHV-1 neurovirulence in vitro, thereby reducing the need for horses as experimental animals...
  33. ncbi Histological study of Trichosomoides nasalis (Nematoda: Trichinelloidea) in the nasal cavities of the murid Arvicanthis niloticus, with associated pathology
    M Diagne
    Departement de Biologie Animale, Faculte des Sciences, Universite Cheikh Anta Diop, Dakar, Senegal
    Parasite 11:351-8. 2004
    ..infected with Trichosomoides nasalis shows that the female worms reside in the epithelial monolayer of the nasal mucosa of the posterior and median cavities. Eggs laid by T...
  34. doi Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen
    Yoshiaki Kitamura
    Department of Otolaryngology, University of Tokushima Graduate School, Japan
    Acta Otolaryngol 132:434-8. 2012
    ..gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in ..
  35. ncbi Measurement of nasal potential difference in young children with an equivocal sweat test following newborn screening for cystic fibrosis
    Isabelle Sermet-Gaudelus
    CRCM and INSERM U845, Hopital Necker, Faculte de Medecine Necker, Universite Rene Descartes, Paris, France
    Thorax 65:539-44. 2010
    ....
  36. doi Prevalence of pathologic findings in the maxillary sinus in cone-beam computerized tomography
    Lutz Ritter
    Interdisciplinary Outpatient Department of Oral Surgery and Implantology, Department of Craniomaxillofacial and Plastic Surgery, University of Cologne, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:634-40. 2011
    ..The aim of this study was to assess the prevalence of pathologic findings in the maxillary sinus by using cone-beam computerized tomography (CBCT)...
  37. ncbi Histological and immunological observations of bacterial and allergic chronic rhinosinusitis in the mouse
    Heng Wang
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Rhinol 22:343-8. 2008
    ..The purpose of this study was to elucidate histological and immunologic features of mouse models of bacterial chronic rhinosinusitis (BCRS) and allergic chronic rhinosinusitis (ACRS)...
  38. pmc Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure
    Benjamin C Moeller
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599 7431, United States
    Chem Res Toxicol 24:162-4. 2011
    The presence of endogenous and exogenous N(2)-hydroxymethyl-dG adducts in DNA from the nasal mucosa and bone marrow of cynomolgus macaques exposed to 1.9 and 6...
  39. ncbi Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa
    Alice S Tarun
    University of California, San Francisco, Medicine, San Francisco, CA, USA
    Chem Senses 28:621-9. 2003
    ..CA enzymatic activity has been demonstrated in the human nasal mucosa using enzyme histochemical methods, but no systematic study of nasal mucosal CA isoenzyme gene expression has ..
  40. ncbi Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis
    Kenji Dejima
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Arch Otolaryngol Head Neck Surg 132:1352-62. 2006
    ..To create well-differentiated cultures of normal and chronic sinusitis paranasal sinus epithelial cells and to compare their electrophysiologic properties...
  41. ncbi Nasal and paranasal sinus anatomy and physiology
    Fuad M Baroody
    Department of Surgery, Section of Otolaryngology Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin Allergy Immunol 19:1-21. 2007
  42. ncbi Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction
    Kai Zhao
    Bioengineering Department, University of Pennsylvania, RM 120 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Chem Senses 29:365-79. 2004
    ....
  43. ncbi Nasal resistance and allergic inflammation depend on allergen type
    Matteo Gelardi
    Dipartimento di Oculistica e Otorinolaringoiatria, Universita di Bari, Bari, Italy
    Int Arch Allergy Immunol 141:384-9. 2006
    ..Allergic rhinitis is characterized by inflammatory cell infiltrate and increased nasal airflow resistance...
  44. pmc Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde
    Kun Lu
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    Chem Res Toxicol 24:159-61. 2011
    ..In contrast, exogenous adducts were not detectable in the bone marrow of rats exposed to 15.2 ppm [(13)CD(2)] formaldehyde...
  45. doi Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro
    Stephan Hackenberg
    Department of Oto Rhino Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Toxicol In Vitro 25:657-63. 2011
    ..The current study focused on the cyto- and genotoxicity of ZnO-NPs in comparison to ZnO powder in primary human nasal mucosa cells cultured in the air-liquid interface...
  46. ncbi Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa
    G J Braunstahl
    Department of Otorhinolaryngology, Erasmus University Medical Center Rotterdam, The Netherlands
    Am J Respir Crit Care Med 164:858-65. 2001
    ..05) in allergic rhinitis patients after SBP. In the nasal mucosa, the numbers of MC(C) and MC(TC) cells decreased significantly, whereas the numbers of [BB1(+)] cells increased ..
  47. pmc Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenza
    Ilona Jaspers
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 43:368-75. 2010
    ....
  48. doi Topographical differences in distribution and responsiveness of trigeminal sensitivity within the human nasal mucosa
    Thomas Meusel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School Technische Universität Dresden, Dresden, Germany
    Pain 151:516-21. 2010
    ..These findings suggest that the presence of topographical and chemosensory differences in the responsiveness of the nasal mucosa to irritants.
  49. ncbi Anatomical mapping of human herpesvirus reservoirs of infection
    Tiansheng Chen
    Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
    Mod Pathol 19:726-37. 2006
    ..CMV was detected in three cases, most commonly in nasal mucosa, trachea, thyroid, intestine, and liver...
  50. ncbi Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis
    R U Pawankar
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Am J Respir Crit Care Med 152:2059-67. 1995
    ..The present study was designed to investigate the expression of IL-13 gene in the epithelial compartment of the nasal mucosa of patients with perennial allergic rhinitis (PAR) to house dust mite, comparing it with that in the nasal ..
  51. ncbi Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polyps
    Z Liu
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Allergy 62:999-1006. 2007
    ....
  52. ncbi Structural and functional differences between putative mucosal inductive sites of the rat
    Adrian W Zuercher
    Department of Biology, University of Pennsylvania, Philadelphia, USA
    Eur J Immunol 32:3191-6. 2002
    ..These data reveal profound qualitative differences between these three mucosal sites, and strongly suggest that BALT is not a mucosal inductive site for reovirus-specific immune responses in the rat...
  53. ncbi Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine
    Takashi Hirano
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
    Immunol Lett 107:131-9. 2006
    ..These kinetic antibody patterns and cellular responses may provide useful information regarding to effective mucosal vaccines against NTHi infections...
  54. ncbi Evaluation of MRSA Select, a new chromogenic medium for the detection of nasal carriage of methicillin-resistant Staphylococcus aureus
    Sana Ben Nsira
    Service de Microbiologie, Hôpital Côte de Nacre, Universite de Caen, 14033 Caen Cedex, France
    Int J Antimicrob Agents 27:561-4. 2006
    ..By contrast, on the single criterion of the colour of colonies for MRSA positivity, the specificity and sensitivity of MRSA Select were high (99.8% and 99%, respectively)...
  55. pmc Forkhead box P3+ T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposis
    T Liu
    Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
    Clin Exp Immunol 163:59-64. 2011
    ..The present study aims to examine the regulatory T cells (T(reg) ) in nasal mucosa of patients with allergic rhinitis (AR) and nasal polyposis (NP)...
  56. ncbi Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
    Fanxue Meng
    US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA
    Regul Toxicol Pharmacol 57:274-83. 2010
    This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR)...
  57. ncbi Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa
    G Kobal
    Institute of Pharmacology and Toxicology, University Erlangen Nurnberg, F R G
    Electroencephalogr Clin Neurophysiol 71:241-50. 1988
    ..Responses to the mixture of carbon dioxide and vanillin appeared significantly earlier (50-150 msec) than responses to either substance alone...
  58. ncbi The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cells
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 149:2759-67. 2003
    ..These results suggest that SasG, Pls and AAP bind to the same as-yet-unidentified receptor on the surface of nasal epithelial cells. In addition, expression of SasG, like Pls, reduced adherence of S. aureus to fibronectin and fibrinogen...
  59. ncbi Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density
    Ana Vila
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostel, 15782 Santiago de Compostela, Spain
    J Control Release 98:231-44. 2004
    ..of Poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) nano- and microparticles on their transport across the nasal mucosa. Particles were made of PLA-PEG copolymers of two different molecular weights (Mw: 37 and 28 kDa) and also PLA ..
  60. ncbi Localization of nitric oxide synthase in human nasal mucosa with nasal allergy
    H Kawamoto
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol Suppl 539:65-70. 1998
    ..To investigate the expression of NOS in human nasal mucosa, histochemical staining for NADPH diaphorase and immunohistochemical staining for NOS isoforms were carried out ..
  61. pmc Iota-Carrageenan is a potent inhibitor of rhinovirus infection
    Andreas Grassauer
    Marinomed Biotechnologie GmbH, Veterinaerplatz 1 HA, A 1210 Vienna, Austria
    Virol J 5:107. 2008
    ..In addition, HRVs are implicated in the worsening of COPD and asthma, as well as the loss of lung transplants. Despite significant efforts, no anti-viral agent is approved for the prevention or treatment of HRV-infection...
  62. ncbi Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis
    Pooja Takhar
    The Randall Division, King s College London, London, United Kingdom
    J Immunol 174:5024-32. 2005
    ..We have investigated the provenance of these B cells in the nasal mucosa in allergic rhinitis...
  63. ncbi In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tract
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Virol Methods 142:105-12. 2007
    ..Molecular and cellular aspects of the interactions of respiratory viruses with the respiratory nasal mucosa are largely unknown. In order to be able to study those interactions in depth, an in vitro model was set up...
  64. ncbi Nasal-associated lymphoid tissue is a mucosal inductive site for virus-specific humoral and cellular immune responses
    Adrian W Zuercher
    Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 168:1796-803. 2002
    ..Together these data provide direct evidence that NALT is a mucosal inductive site for humoral and cellular immune responses in the upper respiratory tract...
  65. ncbi Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis
    Bob Lubamba
    Department of Clinical Chemistry, Universite Catholique de Louvain, Brussels, Belgium
    Am J Respir Crit Care Med 177:506-15. 2008
    ..The effect was observed in vitro and in the presence of doses roughly 300 times larger than those commonly used for treating erectile dysfunction...
  66. ncbi Nasal carriage of Staphylococcus aureus among healthy adults
    Chong Seng Choi
    Department of Clinical Laboratory Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    J Microbiol Immunol Infect 39:458-64. 2006
    ..aureus (MRSA), the prevalence of S. aureus nasal colonization in a population of healthy adults was determined. Factors associated with S. aureus nasal carriage and antibiotic sensitivity patterns of the isolates were also analyzed...
  67. pmc Mechanical endonasal dacryocystorhinostomy with mucosal flaps
    A Tsirbas
    Department of Ophthalmology, Flinders Medical Centre and Queen Elizabeth Hospital, Adelaide, South Australia
    Br J Ophthalmol 87:43-7. 2003
    ..This is a new technique that involves creation of a large rhinostomy and mucosal flaps. The study involved a prospective non-randomised interventional case series with short perioperative follow up...
  68. pmc Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis
    David D Tieu
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill 60607, USA
    J Allergy Clin Immunol 125:667-75. 2010
    ..Decreased epithelial expression of mRNA for S100A7 (psoriasin) and S100A8/A9 (calprotectin) has been reported in patients with chronic rhinosinusitis (CRS)...
  69. ncbi Development of rhinovirus study model using organ culture of turbinate mucosa
    Yong Ju Jang
    Department of Otolaryngolgy, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2dong, Songpa Gu, Seoul 138 736, South Korea
    J Virol Methods 125:41-7. 2005
    ..Our results indicate that the air-liquid interface organ culture of turbinate mucosa could serve as an acceptable in vitro model for studying RV infection...
  70. ncbi Distribution of respiratory mucin proteins in human nasal mucosa
    David A Groneberg
    Department of Medicine, Charite School of Medicine, Humboldt University, Charite Campus Virchow, BMFZ Forum 4 Fach 40, Augustenburger Platz 1, D 13353 Berlin, Germany
    Laryngoscope 113:520-4. 2003
    ..We examined the cellular expression and distribution of two major respiratory mucus-forming glycoproteins, MUC5AC and MUC5B, in normal human nasal tissues...
  71. pmc The nasal dendritic cell-targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumonia
    Kosuke Kataoka
    Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8504, Japan
    Infect Immun 79:2819-28. 2011
    ..elevated numbers of CD8(+) and CD11b(+) DCs and interleukin 2 (IL-2)- and IL-4-producing CD4(+) T cells in the nasal mucosa-associated lymphoid tissues (NALT) and cervical lymph nodes (CLNs)...
  72. ncbi Rhinovirus infection-induced alteration of tight junction and adherens junction components in human nasal epithelial cells
    Nam Kyung Yeo
    Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea
    Laryngoscope 120:346-52. 2010
    ..The objective of this study was to investigate changes in the components of TJs (ZO-1, occluding, and claudin-1) and AJs (E-cadherin) after RV infection in cultured nasal epithelial cells...
  73. doi Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma
    T Sekigawa
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan
    Clin Exp Allergy 39:972-81. 2009
    ..The lower airway lesion and the nasal polyp in AIA are postulated to have common pathogenic features involving aspirin sensitivity that would be reflected in the gene expression profile of AIA polyps...
  74. ncbi Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis
    Heather A Coker
    The Randall Division of Cell and Molecular Biophysics, King s College London, London
    J Allergy Clin Immunol 116:445-52. 2005
    IgE antibody-producing B cells are enriched in the nasal mucosa in patients with allergic rhinitis because of local class switching to IgE. The expressed IgE VH genes also undergo somatic hypermutation in situ to generate clonal families...
  75. ncbi Transport of intranasally instilled fine Fe2O3 particles into the brain: micro-distribution, chemical states, and histopathological observation
    Bing Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
    Biol Trace Elem Res 118:233-43. 2007
    ..The further histopathological observation showed that the neuron fatty degeneration occurred in the CA3 area of hippocampus. Such results imply an adverse impact of inhalation of fine Fe2O3 particles on CNS...
  76. ncbi Transport of nanoparticles across the rat nasal mucosa
    J Brooking
    Institute of Pharmaceutical Sciences, University of Nottingham, Boots Science Building, Science Road, University Park, Nottingham, NG7 2RD, UK
    J Drug Target 9:267-79. 2001
    The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings...
  77. pmc Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:6038-50. 2008
    ..Our results demonstrate that nasal anti-CD3 induces CD4(+)CD25(-)LAP(+) regulatory T cells that suppress lupus in mice and that it is associated with down-regulation of T cell help for autoantibody production...
  78. ncbi Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosa
    S N Snow
    Division of Plastic Surgery, Section of Mohs Surgery, Department of Surgery, University of Wisconsin-Madison, School of Medicine, Madison, Wisconsin 53705, USA
    Dermatol Surg 27:165-70. 2001
    ..Mucosal MCC is rare and may occur as a long-term sequelae after radiation therapy to the skin...
  79. ncbi Correlation between epithelial toxicity and surfactant structure as derived from the effects of polyethyleneoxide surfactants on caco-2 cell monolayers and pig nasal mucosa
    Katarina Ekelund
    Department of Pharmacy, Uppsala University, Box 580, SE 751 23 Uppsala, Sweden
    J Pharm Sci 94:730-44. 2005
    The cell toxic effects of nonionic surfactants were investigated by means of two in vitro models, namely pig nasal mucosa mounted in horizontal Ussing chambers, and Caco-2 cell monolayers...
  80. ncbi Blue nevus of the nasal mucosa
    Simonetta Piana
    Virchows Arch 446:342-3. 2005
  81. ncbi Expression and localization of steroid receptors in human nasal mucosa
    Hideaki Shirasaki
    Department of Otolaryngology, Sapporo Medical School, Sapporo, 060 8543, Japan
    Acta Otolaryngol 124:958-963. 2004
    To investigate the expression of glucocorticoid receptor (GR), oestrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) in nasal mucosa.
  82. ncbi Neuroendocrine cells in the nasal mucosa - preliminary report
    Andrzej Sieskiewicz
    Department of Otolaryngology, Head and Neck Surgery, Medical University of Białystok, Poland
    Folia Histochem Cytobiol 45:123-7. 2007
    ..The aim of the study was the quantitative and morphometric assessment of NC in nasal mucosa in some pathological states.
  83. ncbi Massive apoptosis erodes nasal mucosa of cocaine abusers
    Matteo Trimarchi
    Department of Otorhinolaryngology, San Raffaele Hospital and Vita Salute University San Raffaele, Milano, Italy
    Am J Rhinol 20:160-4. 2006
    ..A threatening occurrence in some cocaine abusers is the progressive destruction of nasal structures (cocaine-induced midline destructive lesions [CIMDL]) that may end in a highly severe disease...
  84. ncbi Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge
    Nathalie Etchart
    Lung Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Eur J Immunol 36:1136-44. 2006
    ..These data show that immunisation with iRSV and OMV maintains a NALT RSV-specific plasma cell population and generates an efficient protective immune response following RSV infection...
  85. ncbi T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa
    Jana Goldmann
    Department of Experimental Neuroimmunology, Charite, Universitatsmedizin, Berlin, Germany
    J Leukoc Biol 80:797-801. 2006
    ..Irrespective of the injection site, we demonstrate their passage through the cribroid plate, appearance in the nasal mucosa, and specific accumulation in one of the cervical lymph nodes.
  86. pmc Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa
    T N Dear
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 10:2813-9. 1991
    ..Therefore, the olfactory mucosa may possess diverse, functionally-distinct odorant-binding proteins which recognize and bind separate classes of odorants...
  87. ncbi Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival
    J Mullol
    IDIBAPS, Rhinology Unit, ENT Department, Hospital Clinic, Deparmtent of Medicine, Universitat de Barcelona, Barcelona, Catalonia, Spain
    Clin Exp Allergy 36:52-8. 2006
    ..Second-generation antihistamines are H(1) receptor antagonists and may have additional anti-inflammatory effects...
  88. ncbi Induction of airway remodeling of nasal mucosa by repetitive allergen challenge in a murine model of allergic rhinitis
    Yune Sung Lim
    Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
    Ann Allergy Asthma Immunol 98:22-31. 2007
    ..Although many studies regarding airway remodeling in asthma have been reported, only a few studies have investigated airway remodeling in allergic rhinitis...
  89. ncbi Topographical differences in the trigeminal sensitivity of the human nasal mucosa
    Mandy Scheibe
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
    Neuroreport 17:1417-20. 2006
    ..These results are compatible with the idea that the trigeminal system acts as a sentinel of the human airways...
  90. ncbi Production of IgA monoclonal antibody against Shiga toxin binding subunits employing nasal-associated lymphoid tissue
    Y Imai
    Department of Microbiology and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    J Immunol Methods 302:125-35. 2005
    ....
  91. doi Comparison of three chromogenic media and enrichment broth media for the detection of methicillin-resistant Staphylococcus aureus from mucocutaneous screening specimens : Comparison of MRSA chromogenic media
    C Nonhoff
    Laboratoire de Référence MRSA Staphylocoques, Service de Microbiologie, Hopital Erasme, Bruxelles, Belgium
    Eur J Clin Microbiol Infect Dis 28:363-9. 2009
    ..In conclusion, all media showed equivalent sensitivities after 18 h of incubation and performed better when enriched before inoculation. MRSA-Screen was more sensitive but less specific than the two other media after 42 h of incubation...
  92. ncbi Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes
    Frode L Jahnsen
    LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
    Am J Respir Cell Mol Biol 30:31-7. 2004
    ..How these two cell populations regulate the tone of the local adaptive immune system should be the focus of further studies...
  93. ncbi [Expression of thymic stromal lymphopoietin in nasal mucosa of a mouse model with allergic rhinitis]
    Meili Xu
    Department of ICU, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:794-5, 799. 2009
    To investigate the expression of thymic stromal lymphopoietin (TSLP) in the nasal mucosa of mouse with allergic rhinitis.
  94. ncbi A morphologic and immunohistochemical study of nasal mucosa in leatherworkers
    Annarita Palomba
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Am J Rhinol 22:356-60. 2008
    ..The purpose of this study was to investigate the histological changes and modifications in the phenotype of epithelial cells in nasal mucosa of leather workers.
  95. ncbi Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccine
    Laura L Hammitt
    Section of Infectious Diseases, Department of Pediatrics, University of Colorado Denver, Denver, CO, United States
    Vaccine 27:7359-66. 2009
    ..PBMCs from subjects receiving CAIV showed a higher proportion of functional, tissue-tropic T-cells (CD4+CD69+CD18+MIP1alpha+) specific for homotypic and heterosubtypic strains of influenza by flow cytometry...
  96. ncbi Human nasal mucosa contains tissue-resident immunologically responsive mesenchymal stromal cells
    Mark Jakob
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Germany
    Stem Cells Dev 19:635-44. 2010
    ..Here, we report for the first time on the isolation and characterization of multipotent nasal mucosa-derived mesenchymal stromal cells (nm-MSC)...
  97. ncbi Neuroendocrine cells of nasal mucosa are a cellular source of brain-derived neurotrophic factor
    L Jornot
    Division of Pulmonary Medicine, Dept of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    Eur Respir J 32:769-74. 2008
    ..Therefore, airway mucosa might contribute to neurogenic inflammation through increased secretion of brain-derived neurotrophic factor by neuroendocrine cells under inflammatory conditions...
  98. doi Regression of polypoid nasal mucosa after systemic corticosteroid therapy: a proteomics study
    Armin Farajzadeh Deroee
    Department of Otorhinolaryngology and Head and Neck Surgery, Ernst Moritz Arndt University, Greifswald, Germany
    Am J Rhinol Allergy 23:480-5. 2009
    ..Identifying and comparing the protein profile of chronic rhinosinusitis (CRS) with NP before and after treatment with GCs can help to clarify NP pathogenesis and mechanisms of corticosteroid effects on NP...
  99. ncbi Nasal potential difference measurements in patients with atypical cystic fibrosis
    M Wilschanski
    Dept of Pediatrics, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel
    Eur Respir J 17:1208-15. 2001
    ..This calculation may assist in the diagnostic work-up of patients whose diagnosis is questionable...
  100. ncbi Differential proteomic analysis of nasal polyps, chronic sinusitis, and normal nasal mucosa tissues
    Wu Min-man
    Department of Otorhinolaryngology, The First Affiliated Hospital of Yunnan College of Traditional Chinese Medicine, Kunming, China
    Otolaryngol Head Neck Surg 141:364-8. 2009
    To compare protein expression in nasal polyps, chronic sinusitis, and normal nasal mucosa tissues using proteomic technology.
  101. ncbi Uptake of cobalt from the nasal mucosa into the brain via olfactory pathways in rats
    Eva Persson
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, BMC, Box 573, S 751 23 Uppsala, Sweden
    Toxicol Lett 145:19-27. 2003
    ..We consider that the olfactory route of entry of cobalt into the brain may be important and should be taken into account when risk assessments are performed concerning occupational inhalation of this metal...

Research Grants72

  1. PARABRACHIAL NUCLEI--ROLE IN RESPIRATORY SYSTEM DEFENSE
    Thomas Dick; Fiscal Year: 1992
    ..This reflex is elicited by the branch of trigeminal nerve that innervates the nasal mucosa. If irritants persist in the upper airway or enter the lower airway, then more complex changes occur in the ..
  2. ALCOHOL METABOLISM--ROLE OF P-450 OXYGENASES
    Minor Coon; Fiscal Year: 1992
    ..P-450 IIE2 to homogeneity after heterologous expression and to determine whether P-450 IIE1 in kidney, nasal mucosa, and lung, and P-450 IIE2 in lung are different from their counterparts in liver, (b) to determine whether P-..
  3. ALCOHOL METABOLISM--ROLE OF P-450 OXYGENASES
    Minor Coon; Fiscal Year: 1993
    ..P-450 IIE2 to homogeneity after heterologous expression and to determine whether P-450 IIE1 in kidney, nasal mucosa, and lung, and P-450 IIE2 in lung are different from their counterparts in liver, (b) to determine whether P-..
  4. MECHANISMS OF HUMAN AIRWAY REACTIONS TO DRY AIR
    Alkis Togias; Fiscal Year: 1993
    ..The human nasal mucosa is very accessible to experimentation and can provide valuable information on the pathophysiology of both upper ..
  5. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2009
    ..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
  6. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2010
    ..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
  7. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen Donovan; Fiscal Year: 2007
    ..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
  8. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen Donovan; Fiscal Year: 2009
    ..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
  9. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen D Donovan; Fiscal Year: 2010
    ..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
  10. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen Donovan; Fiscal Year: 2009
    ..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
  11. PYRIDINE--ENZYME INDUCTION, METABOLISM, AND TOXICITY
    Melissa Runge Morris; Fiscal Year: 1990
    ..provide important information on the induction of cytochrome P-450 in extrahepatic tissues, particularly the nasal mucosa and lung, and the effects of induction on xenobiotic metabolism and toxicity in these tissues...
  12. INTERPLAY OF ALLERGIC RHINITIS AND NASAL HUMIDIFICATION
    Robert Naclerio; Fiscal Year: 1999
    ..chamber to test the hypotheses that: a) the induction of allergic inflammation reduces the ability of the nasal mucosa to warm and humidify CDA; b) the nasal response to CDA of individuals with perennial allergic rhinitis exceeds ..
  13. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ..tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
  14. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 1999
    ..tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
  15. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2000
    ..tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
  16. WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in AD
    Neelima B Chauhan; Fiscal Year: 2012
    ..by virtue of its endocytic uptake preference, but will also facilitate passive diffusion of 3A1 due to its nasal mucosa-like biochemical composition, maximizing immunotherapeutic efficacy of intranasal passive immunization, to be ..
  17. TOXIC RESPONSES OF NASAL MUCOSA TO INHALED IRRITANTS
    John Morris; Fiscal Year: 1999
    ..Substance P exerts a variety of effects in human and rodent nasal mucosa including vasodilation and increased blood flow, increased vascular permeability leading to edemagenesis, and ..
  18. TOXIC RESPONSES OF NASAL MUCOSA TO INHALED IRRITANTS
    John Morris; Fiscal Year: 2000
    ..Substance P exerts a variety of effects in human and rodent nasal mucosa including vasodilation and increased blood flow, increased vascular permeability leading to edemagenesis, and ..
  19. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2001
    ..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
  20. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2000
    ..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
  21. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
  22. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2002
    ..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
  23. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 1999
    ..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
  24. T cell responses of nasal mucosa and lymphoid tissues
    Allen Harmsen; Fiscal Year: 2002
    ..However in man, influenza normally first infects the nasal mucosa, and then spreads progressively to the trachea and to the pulmonary airways...
  25. T cell responses of nasal mucosa and lymphoid tissues
    Allen Harmsen; Fiscal Year: 2001
    ..However in man, influenza normally first infects the nasal mucosa, and then spreads progressively to the trachea and to the pulmonary airways...
  26. T cell responses of nasal mucosa and lymphoid tissues
    Allen Harmsen; Fiscal Year: 2004
    ..However in man, influenza normally first infects the nasal mucosa, and then spreads progressively to the trachea and to the pulmonary airways...
  27. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 2000
    ..Adhesion to the nasal mucosa increases the transit time of the microparticles and facilitates absorption of these GTF-containing ..
  28. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 1999
    ..Adhesion to the nasal mucosa increases the transit time of the microparticles and facilitates absorption of these GTF-containing ..
  29. Nasal Contour Pack for Epistaxis
    PAUL BUREK; Fiscal Year: 2002
    ..Desiccated sponges are solid and immalleable during insertion, often damaging the nasal mucosa. RBDC proposes to develop and test the Nasal Contour Pack (C-Pack)...
  30. ARYL AND ALCOHOL SULFOTRANSFERASES IN DRUG METABOLISM
    MICHAEL DUFFEL; Fiscal Year: 1993
    ..complementarity in the intratissue localizations and distributions of the two enzymes in liver, skin, lung, and nasal mucosa of both male and female rats...
  31. CLINICAL OLFACTORY RESEARCH CENTER
    MAXWELL MOZELL; Fiscal Year: 1993
    ..in airflow reduces the number of odorant molecules which would normally reach the chemoreceptors of the nasal mucosa, the trigeminal component of olfactory experience would be compromised as well...
  32. CLINICAL OLFACTORY RESEARCH CENTER
    MAXWELL MOZELL; Fiscal Year: 1990
    ..in airflow reduces the number of odorant molecules which would normally reach the chemoreceptors of the nasal mucosa, the trigeminal component of olfactory experience would be compromised as well...
  33. Human CYP2A and respiratory tract xenobiotic toxicity
    Xinxin Ding; Fiscal Year: 2003
    ..respiratory tract and is much more abundant than CYP2A6, the other functional member of the CYP2A subfamily, in nasal mucosa and lung; (b) heterologously expressed CYP2A13 is highly active in the metabolic activation of several ..
  34. Human CYP2A and respiratory tract xenobiotic toxicity
    Xinxin Ding; Fiscal Year: 2004
    ..respiratory tract and is much more abundant than CYP2A6, the other functional member of the CYP2A subfamily, in nasal mucosa and lung; (b) heterologously expressed CYP2A13 is highly active in the metabolic activation of several ..
  35. Human CYP2A and respiratory tract xenobiotic toxicity
    Xinxin Ding; Fiscal Year: 2006
    ..respiratory tract and is much more abundant than CYP2A6, the other functional member of the CYP2A subfamily, in nasal mucosa and lung; (b) heterologously expressed CYP2A13 is highly active in the metabolic activation of several ..
  36. Human CYP2A and respiratory tract xenobiotic toxicity
    Xinxin Ding; Fiscal Year: 2007
    ..respiratory tract and is much more abundant than CYP2A6, the other functional member of the CYP2A subfamily, in nasal mucosa and lung; (b) heterologously expressed CYP2A13 is highly active in the metabolic activation of several ..
  37. Human CYP2A and respiratory tract xenobiotic toxicity
    Xinxin Ding; Fiscal Year: 2005
    ..respiratory tract and is much more abundant than CYP2A6, the other functional member of the CYP2A subfamily, in nasal mucosa and lung; (b) heterologously expressed CYP2A13 is highly active in the metabolic activation of several ..
  38. Proteomics of Staphylococcus aureus nasal carriage
    Alexander Cole; Fiscal Year: 2003
    The human nasal mucosa is an accessible and clinically important model for the study of microbial interactions with host defenses...
  39. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2009
    ..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa. An advantage of this route is that it should deliver virus to the entire trigeminal nerve, including the ..
  40. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2007
    ..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa. An advantage of this route is that it should deliver virus to the entire trigeminal nerve, including the ..
  41. Proteomics of Staphylococcus aureus nasal carriage
    Alexander Cole; Fiscal Year: 2002
    The human nasal mucosa is an accessible and clinically important model for the study of microbial interactions with host defenses...
  42. Mechanisms of prion transport
    Richard A Bessen; Fiscal Year: 2012
    ..the pathway of prion movement in neurons, studies will investigate the spread of prions between the brain and nasal mucosa within olfactory receptor neurons...
  43. Nasal Contour Pack for Epistaxis
    PAUL BUREK; Fiscal Year: 2003
    ..Desiccated sponges are solid and immalleable during insertion, often damaging the nasal mucosa. RBDC developed and tested the Pillow Pac on an anatomical model in Phase I...
  44. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004
    ..hypothesis that chlipoplexes will deliver effectively the pDNAs without any significant adverse effects in the nasal mucosa and provide significant protection against viral infections...
  45. Nasal Contour Pack for Epistaxis
    KENNETH WEIL; Fiscal Year: 2004
    ..Desiccated sponges are solid and immalleable during insertion, often damaging the nasal mucosa. RBDC developed and tested the Pillow Pac on an anatomical model in Phase I...
  46. Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal Pathogenesis
    Rituparna Das; Fiscal Year: 2011
    ..the immune system with the bacterium will allow us to appreciate how pneumococcus exists as a colonizer in the nasal mucosa but causes destructive invasive disease in the lungs...
  47. PREVENTION OF NASAL CAVITY TUMORS BY CASTRATION
    PARVIZ POUR; Fiscal Year: 1990
    ..activities of P-450 isozymes, particularly those with sex hormone-dependent functions, will be investigated in nasal mucosa and livers of these rats...
  48. DISPOSITION OF INHALED TOXICANTS IN THE OLFACTORY SYSTEM
    Johnnye Lewis; Fiscal Year: 1992
    ..By inhibiting specific metabolic pathways, we can assess the role of metabolism in the nasal mucosa and the olfactory bulbs on the disposition of solvents varying in metabolic pathways and the interaction of ..
  49. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2001
    ..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
  50. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2000
    ..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
  51. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2003
    ..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
  52. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2002
    ..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
  53. Nasal Injury due to Exposure to Ozone
    Jack Harkema; Fiscal Year: 2003
    ..will be compared to biochemical changes in intracellular and extracellular antioxidants present in the nasal mucosa and extracellular airway lining fluid, respectively...
  54. TOXICOLOGY OF NASAL GAS DEPOSITION IN FIVE SPECIES
    John Morris; Fiscal Year: 1990
    It has recently been discovered that the nasal mucosa is rich in xenobiotic metabolizing enzymes, however, their quantitative importance in the in vivo setting is not known...
  55. NITROSAMINE ACTIVATION AND EXTRAHEPATIC P450S
    Sharon Murphy; Fiscal Year: 1999
    ..Preliminary studies with human P450s, rat nasal mucosa and rat esophageal microsomes, indicate that P450 2A enzymes play an important role in the activation of ..
  56. CORE--ANIMAL RESOURCES
    Frances Lund; Fiscal Year: 2004
    ..in the lung", Project 3 "CD8+ T cell memory to respiratory virus infections" and Project 4 "T cell responses of nasal mucosa and lymphoid tissues". The core unit leader is Dr...
  57. CORE--ANIMAL RESOURCES
    Frances Lund; Fiscal Year: 2001
    ..in the lung", Project 3 "CD8+ T cell memory to respiratory virus infections" and Project 4 "T cell responses of nasal mucosa and lymphoid tissues". The core unit leader is Dr...
  58. R01-Williajm - Double-Blind Placebo-Controlled trial of Nicotine Nasal Spray as a
    Jill Williams; Fiscal Year: 2009
    ..Nicotine Nasal Spray (NNS) differs from other forms of NRT in that nicotine is absorbed rapidly through the nasal mucosa and produces physiological effects that are expected to speed relief of withdrawal and craving...
  59. NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS
    Tomas Ganz; Fiscal Year: 2001
    ..the search for the underlying defect in mucosal immunity: (1) identify the specific topographic areas of the nasal mucosa in which S. aureus is carried; (2) characterize the differences in mucus composition, anti-S...
  60. NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS
    Tomas Ganz; Fiscal Year: 2000
    ..the search for the underlying defect in mucosal immunity: (1) identify the specific topographic areas of the nasal mucosa in which S. aureus is carried; (2) characterize the differences in mucus composition, anti-S...
  61. R01-Williajm - Double-Blind Placebo-Controlled trial of Nicotine Nasal Spray as a
    Jill M Williams; Fiscal Year: 2010
    ..Nicotine Nasal Spray (NNS) differs from other forms of NRT in that nicotine is absorbed rapidly through the nasal mucosa and produces physiological effects that are expected to speed relief of withdrawal and craving...
  62. EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGEN
    Robert Naclerio; Fiscal Year: 1992
    ..the nasal secretions for the presence of inflammatory mediators and cells before and after exposing the nasal mucosa of volunteers to pollen antigens, this proposal plans to improve the human model of allergic rhinitis in order ..
  63. EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGEN
    Robert Naclerio; Fiscal Year: 1990
    ..the nasal secretions for the presence of inflammatory mediators and cells before and after exposing the nasal mucosa of volunteers to pollen antigens, this proposal plans to improve the human model of allergic rhinitis in order ..
  64. DEVELOPMENT OF TRANSNASAL KETAMINE FOR BREAKTHROUGH PAIN
    FRED MERMELESTEIN; Fiscal Year: 2000
    ..does not induce changes in blood pressure or heart rate and does not demonstrate evidence of toxicity to the nasal mucosa following repetitive administration...
  65. Nasal carriage of S. aureus: host-pathogen interactions
    Alexander Cole; Fiscal Year: 2007
    ..We hypothesize that 1) the expression of lipocalin-1 is dysregulated in the nasal mucosa of SA carriers, contributing to the progressive colonization of SA, 2) correcting the lipocalin-1 deficiency ..