nasal mucosa

Summary

Summary: The mucous lining of the NASAL CAVITY, including lining of the NOSTRIL (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.

Top Publications

  1. ncbi PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium
    C Rudack
    Department of Otorhinolaryngology, Head and Neck Surgery, IZK Münster and Boltzmann Institute for Immunobiology of the Skin, Munster, Germany
    Clin Exp Allergy 37:1009-22. 2007
  2. ncbi Nasal-associated lymphoid tissue (NALT): frequency and localization in young children
    A S Debertin
    Department Legal Medicine, Medical School of Hannover, Hannover, Germany
    Clin Exp Immunol 134:503-7. 2003
  3. ncbi A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity
    Tatsuya Fukuiwa
    The Immunobiology Vaccine Center, Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Vaccine 26:4849-59. 2008
  4. ncbi Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults
    Meri K Tulic
    Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
    Lancet 363:1689-97. 2004
  5. ncbi Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine
    Takashi Hirano
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
    Immunol Lett 107:131-9. 2006
  6. ncbi Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Microbiol 136:341-6. 2009
  7. ncbi Anatomical mapping of human herpesvirus reservoirs of infection
    Tiansheng Chen
    Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555-0741, USA
    Mod Pathol 19:726-37. 2006
  8. ncbi Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polyps
    Z Liu
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Allergy 62:999-1006. 2007
  9. ncbi Evaluation of MRSA Select, a new chromogenic medium for the detection of nasal carriage of methicillin-resistant Staphylococcus aureus
    Sana Ben Nsira
    Service de Microbiologie, , , 14033 Caen Cedex, France
    Int J Antimicrob Agents 27:561-4. 2006
  10. ncbi Structural and functional differences between putative mucosal inductive sites of the rat
    Adrian W Zuercher
    Department of Biology, University of Pennsylvania, Philadelphia, USA
    Eur J Immunol 32:3191-6. 2002

Research Grants

  1. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen Donovan; Fiscal Year: 2009
  2. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2009
  3. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2010
  4. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen D Donovan; Fiscal Year: 2010
  5. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
  6. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
  7. Human CYP2A and respiratory tract xenobiotic toxicity
    Xinxin Ding; Fiscal Year: 2007
  8. Proteomics of Staphylococcus aureus nasal carriage
    Alexander Cole; Fiscal Year: 2003
  9. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2007
  10. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004

Detail Information

Publications237 found, 100 shown here

  1. ncbi PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium
    C Rudack
    Department of Otorhinolaryngology, Head and Neck Surgery, IZK Münster and Boltzmann Institute for Immunobiology of the Skin, Munster, Germany
    Clin Exp Allergy 37:1009-22. 2007
    ..The effects of protease-activated receptor-2 (PAR-2) stimulation on inflammation mechanisms of chronic rhinosinusitis (CRS) are still unknown...
  2. ncbi Nasal-associated lymphoid tissue (NALT): frequency and localization in young children
    A S Debertin
    Department Legal Medicine, Medical School of Hannover, Hannover, Germany
    Clin Exp Immunol 134:503-7. 2003
    ..Clearly in contrast to rodents human NALT was found disseminated in the nasal mucosa with typical morphological features in 38% of all children, mainly in the middle concha, with similar ..
  3. ncbi A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity
    Tatsuya Fukuiwa
    The Immunobiology Vaccine Center, Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Vaccine 26:4849-59. 2008
    ..These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly...
  4. ncbi Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults
    Meri K Tulic
    Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
    Lancet 363:1689-97. 2004
    ..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults.
  5. ncbi Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine
    Takashi Hirano
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
    Immunol Lett 107:131-9. 2006
    ..These kinetic antibody patterns and cellular responses may provide useful information regarding to effective mucosal vaccines against NTHi infections...
  6. ncbi Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Microbiol 136:341-6. 2009
    ..historical PRV strains, single infected cells and plaques of infected cells were quantified at 12 and 36hpi in nasal mucosa explants for seven European PRV strains, isolated in the 1960s (Becker, NIA1), the 1970s (NS374, NIA3, 75V19) ..
  7. ncbi Anatomical mapping of human herpesvirus reservoirs of infection
    Tiansheng Chen
    Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555-0741, USA
    Mod Pathol 19:726-37. 2006
    ..CMV was detected in three cases, most commonly in nasal mucosa, trachea, thyroid, intestine, and liver...
  8. ncbi Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polyps
    Z Liu
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Allergy 62:999-1006. 2007
    ....
  9. ncbi Evaluation of MRSA Select, a new chromogenic medium for the detection of nasal carriage of methicillin-resistant Staphylococcus aureus
    Sana Ben Nsira
    Service de Microbiologie, , , 14033 Caen Cedex, France
    Int J Antimicrob Agents 27:561-4. 2006
    ..By contrast, on the single criterion of the colour of colonies for MRSA positivity, the specificity and sensitivity of MRSA Select were high (99.8% and 99%, respectively)...
  10. ncbi Structural and functional differences between putative mucosal inductive sites of the rat
    Adrian W Zuercher
    Department of Biology, University of Pennsylvania, Philadelphia, USA
    Eur J Immunol 32:3191-6. 2002
    ..These data reveal profound qualitative differences between these three mucosal sites, and strongly suggest that BALT is not a mucosal inductive site for reovirus-specific immune responses in the rat...
  11. ncbi Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis
    R U Pawankar
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Am J Respir Crit Care Med 152:2059-67. 1995
    ..The present study was designed to investigate the expression of IL-13 gene in the epithelial compartment of the nasal mucosa of patients with perennial allergic rhinitis (PAR) to house dust mite, comparing it with that in the nasal ..
  12. ncbi Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenza
    Ilona Jaspers
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 43:368-75. 2010
    ....
  13. ncbi Forkhead box P3+ T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposis
    T Liu
    Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
    Clin Exp Immunol 163:59-64. 2011
    ..The present study aims to examine the regulatory T cells (T(reg) ) in nasal mucosa of patients with allergic rhinitis (AR) and nasal polyposis (NP)...
  14. ncbi Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
    Fanxue Meng
    US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA
    Regul Toxicol Pharmacol 57:274-83. 2010
    This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR)...
  15. ncbi Topographical differences in distribution and responsiveness of trigeminal sensitivity within the human nasal mucosa
    Thomas Meusel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School Technische Universität Dresden, Dresden, Germany
    Pain 151:516-21. 2010
    ..These findings suggest that the presence of topographical and chemosensory differences in the responsiveness of the nasal mucosa to irritants.
  16. ncbi Transport of nanoparticles across the rat nasal mucosa
    J Brooking
    Institute of Pharmaceutical Sciences, University of Nottingham, Boots Science Building, Science Road, University Park, Nottingham, NG7 2RD, UK
    J Drug Target 9:267-79. 2001
    The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings...
  17. ncbi In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tract
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Virol Methods 142:105-12. 2007
    ..Molecular and cellular aspects of the interactions of respiratory viruses with the respiratory nasal mucosa are largely unknown. In order to be able to study those interactions in depth, an in vitro model was set up...
  18. ncbi Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:6038-50. 2008
    ..Our results demonstrate that nasal anti-CD3 induces CD4(+)CD25(-)LAP(+) regulatory T cells that suppress lupus in mice and that it is associated with down-regulation of T cell help for autoantibody production...
  19. ncbi Uptake of cobalt from the nasal mucosa into the brain via olfactory pathways in rats
    Eva Persson
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, BMC, Box 573, S 751 23 Uppsala, Sweden
    Toxicol Lett 145:19-27. 2003
    ..We consider that the olfactory route of entry of cobalt into the brain may be important and should be taken into account when risk assessments are performed concerning occupational inhalation of this metal...
  20. ncbi Massive apoptosis erodes nasal mucosa of cocaine abusers
    Matteo Trimarchi
    Department of Otorhinolaryngology, San Raffaele Hospital and Vita-Salute University San Raffaele, Milano, Italy
    Am J Rhinol 20:160-4. 2006
    ..Biopsy specimens of nasal mucosa were analyzed by immunohistochemistry for caspases-3, -9 and -8 and by the terminal deoxynucleotidyl ..
  21. ncbi Expression and localization of steroid receptors in human nasal mucosa
    Hideaki Shirasaki
    Department of Otolaryngology, Sapporo Medical School, Sapporo, 060 8543, Japan
    Acta Otolaryngol 124:958-963. 2004
    To investigate the expression of glucocorticoid receptor (GR), oestrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) in nasal mucosa.
  22. ncbi Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge
    Nathalie Etchart
    Lung Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Eur J Immunol 36:1136-44. 2006
    ..These data show that immunisation with iRSV and OMV maintains a NALT RSV-specific plasma cell population and generates an efficient protective immune response following RSV infection...
  23. ncbi Neuroendocrine cells in the nasal mucosa - preliminary report
    Andrzej Sieskiewicz
    Department of Otolaryngology, Head and Neck Surgery, Medical University of Białystok, Poland
    Folia Histochem Cytobiol 45:123-7. 2007
    ..The aim of the study was the quantitative and morphometric assessment of NC in nasal mucosa in some pathological states...
  24. ncbi Blue nevus of the nasal mucosa
    Simonetta Piana
    Virchows Arch 446:342-3. 2005
  25. ncbi Distribution of respiratory mucin proteins in human nasal mucosa
    David A Groneberg
    Department of Medicine, Charite School of Medicine, Humboldt University, Charite Campus Virchow, BMFZ Forum 4 Fach 40, Augustenburger Platz 1, D 13353 Berlin, Germany
    Laryngoscope 113:520-4. 2003
    ..We examined the cellular expression and distribution of two major respiratory mucus-forming glycoproteins, MUC5AC and MUC5B, in normal human nasal tissues...
  26. ncbi Topographical differences in the trigeminal sensitivity of the human nasal mucosa
    Mandy Scheibe
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
    Neuroreport 17:1417-20. 2006
    ..These results are compatible with the idea that the trigeminal system acts as a sentinel of the human airways...
  27. ncbi Correlation between epithelial toxicity and surfactant structure as derived from the effects of polyethyleneoxide surfactants on caco-2 cell monolayers and pig nasal mucosa
    Katarina Ekelund
    Department of Pharmacy, Uppsala University, Box 580, SE 751 23 Uppsala, Sweden
    J Pharm Sci 94:730-44. 2005
    The cell toxic effects of nonionic surfactants were investigated by means of two in vitro models, namely pig nasal mucosa mounted in horizontal Ussing chambers, and Caco-2 cell monolayers...
  28. ncbi Staphylococcus aureus nasal carriage in a student community: prevalence, clonal relationships, and risk factors
    Werner E Bischoff
    Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA
    Infect Control Hosp Epidemiol 25:485-91. 2004
    ..Factors for azithromycin resistance were non-medical students and antibiotic use in the past 6 months. CONCLUSION: Older male volunteers suffering from chronic sinusitis and not taking antibiotics were at higher risk for carrying SA...
  29. ncbi Nasal mucosa in natural colds: effects of allergic rhinitis and susceptibility to recurrent sinusitis
    O P Alho
    Department of Otorhinolaryngology, University of Oulu, Finland
    Clin Exp Immunol 137:366-72. 2004
    ..of allergic rhinitis or susceptibility to recurrent sinusitis affects the structural and cellular changes in nasal mucosa during natural colds and convalescence...
  30. ncbi T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa
    Jana Goldmann
    Department of Experimental Neuroimmunology, Charit, , Berlin, Germany
    J Leukoc Biol 80:797-801. 2006
    ..Irrespective of the injection site, we demonstrate their passage through the cribroid plate, appearance in the nasal mucosa, and specific accumulation in one of the cervical lymph nodes.
  31. ncbi Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes
    Frode L Jahnsen
    LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
    Am J Respir Cell Mol Biol 30:31-7. 2004
    ..How these two cell populations regulate the tone of the local adaptive immune system should be the focus of further studies...
  32. ncbi Mechanical endonasal dacryocystorhinostomy with mucosal flaps
    A Tsirbas
    Department of Ophthalmology, Flinders Medical Centre and Queen Elizabeth Hospital, Adelaide, South Australia
    Br J Ophthalmol 87:43-7. 2003
    ..This is a new technique that involves creation of a large rhinostomy and mucosal flaps. The study involved a prospective non-randomised interventional case series with short perioperative follow up...
  33. ncbi Induction of airway remodeling of nasal mucosa by repetitive allergen challenge in a murine model of allergic rhinitis
    Yune Sung Lim
    Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
    Ann Allergy Asthma Immunol 98:22-31. 2007
    ..Although many studies regarding airway remodeling in asthma have been reported, only a few studies have investigated airway remodeling in allergic rhinitis...
  34. ncbi Nasal potential difference measurements in patients with atypical cystic fibrosis
    M Wilschanski
    Dept of Pediatrics, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel
    Eur Respir J 17:1208-15. 2001
    ..This calculation may assist in the diagnostic work-up of patients whose diagnosis is questionable...
  35. ncbi Differential proteomic analysis of nasal polyps, chronic sinusitis, and normal nasal mucosa tissues
    Wu Min-man
    Department of Otorhinolaryngology, The First Affiliated Hospital of Yunnan College of Traditional Chinese Medicine, Kunming, China
    Otolaryngol Head Neck Surg 141:364-8. 2009
    To compare protein expression in nasal polyps, chronic sinusitis, and normal nasal mucosa tissues using proteomic technology.
  36. ncbi Regression of polypoid nasal mucosa after systemic corticosteroid therapy: a proteomics study
    Armin Farajzadeh Deroee
    Department of Otorhinolaryngology and Head and Neck Surgery, Ernst Moritz Arndt University, Greifswald, Germany
    Am J Rhinol Allergy 23:480-5. 2009
    ..Identifying and comparing the protein profile of chronic rhinosinusitis (CRS) with NP before and after treatment with GCs can help to clarify NP pathogenesis and mechanisms of corticosteroid effects on NP...
  37. ncbi Human nasal mucosa contains tissue-resident immunologically responsive mesenchymal stromal cells
    Mark Jakob
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Germany
    Stem Cells Dev 19:635-44. 2010
    ..Here, we report for the first time on the isolation and characterization of multipotent nasal mucosa-derived mesenchymal stromal cells (nm-MSC)...
  38. ncbi [Expression of thymic stromal lymphopoietin in nasal mucosa of a mouse model with allergic rhinitis]
    Meili Xu
    Department of ICU, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:794-5, 799. 2009
    To investigate the expression of thymic stromal lymphopoietin (TSLP) in the nasal mucosa of mouse with allergic rhinitis.
  39. ncbi Effects of minimal persistent inflammation on nasal mucosa of experimental allergic rhinitis
    Fei Lei
    Department of Otorhinolaryngology Head and Neck Surgery, China Japan Union Hospital, Bethune Faculty of Medicine, Jilin University, Changchun, China
    Am J Rhinol Allergy 24:e23-8. 2010
    ..This study investigates whether long-time MPI during allergic rhinitis (AR) results in some features of tissue remodeling in the nasal mucosa.
  40. ncbi Early events in peripheral regulatory T cell induction via the nasal mucosa
    Wendy W J Unger
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Immunol 171:4592-603. 2003
    ..We are the first to demonstrate that functional T(R) cells, which reside within both CD25(+) and CD25(-) subsets, can be isolated from CLN as early as 3 days after nasal OVA application...
  41. ncbi Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explants
    Annelies P Vandekerckhove
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Gen Virol 91:2019-28. 2010
    ..Finally, this study showed that equine respiratory explants are a valuable and reproducible model to study EHV-1 neurovirulence in vitro, thereby reducing the need for horses as experimental animals...
  42. ncbi Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa
    T N Dear
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 10:2813-9. 1991
    ..Therefore, the olfactory mucosa may possess diverse, functionally-distinct odorant-binding proteins which recognize and bind separate classes of odorants...
  43. ncbi Production of IgA monoclonal antibody against Shiga toxin binding subunits employing nasal-associated lymphoid tissue
    Y Imai
    Department of Microbiology and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    J Immunol Methods 302:125-35. 2005
    ....
  44. ncbi Clara cell 10-kDa protein expression in chronic rhinosinusitis and its cytokine-driven regulation in sinonasal mucosa
    Z Liu
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Allergy 64:149-57. 2009
    ....
  45. ncbi HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis
    Ken-Ichi Takano
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
    J Histochem Cytochem 53:611-9. 2005
    ..we investigated the expression and function of tight junctions and characterized DCs in the epithelium of nasal mucosa from patients with allergic rhinitis...
  46. ncbi A morphologic and immunohistochemical study of nasal mucosa in leatherworkers
    Annarita Palomba
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Am J Rhinol 22:356-60. 2008
    ..The purpose of this study was to investigate the histological changes and modifications in the phenotype of epithelial cells in nasal mucosa of leather workers.
  47. ncbi Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells
    A Xaubet
    , , , Barcelona, Spain
    Respir Med 95:408-14. 2001
    ..of budesonide and nedocromil sodium on the secretion of IL-6 and IL-8 by cultured epithelial cells from healthy nasal mucosa and nasal polyps...
  48. ncbi Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival
    J Mullol
    IDIBAPS, Rhinology Unit, ENT Department, Hospital Clinic, Deparmtent of Medicine, Universitat de Barcelona, Barcelona, Catalonia, Spain
    Clin Exp Allergy 36:52-8. 2006
    ..Second-generation antihistamines are H(1) receptor antagonists and may have additional anti-inflammatory effects...
  49. ncbi Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosa
    S N Snow
    Division of Plastic Surgery, Section of Mohs Surgery, Department of Surgery, University of Wisconsin-Madison, School of Medicine, Madison, Wisconsin 53705, USA
    Dermatol Surg 27:165-70. 2001
    ..Mucosal MCC is rare and may occur as a long-term sequelae after radiation therapy to the skin...
  50. ncbi Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccine
    Laura L Hammitt
    Section of Infectious Diseases, Department of Pediatrics, University of Colorado Denver, Denver, CO, United States
    Vaccine 27:7359-66. 2009
    ..PBMCs from subjects receiving CAIV showed a higher proportion of functional, tissue-tropic T-cells (CD4+CD69+CD18+MIP1alpha+) specific for homotypic and heterosubtypic strains of influenza by flow cytometry...
  51. ncbi Neuroendocrine cells of nasal mucosa are a cellular source of brain-derived neurotrophic factor
    L Jornot
    Division of Pulmonary Medicine, Dept of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    Eur Respir J 32:769-74. 2008
    ..Therefore, airway mucosa might contribute to neurogenic inflammation through increased secretion of brain-derived neurotrophic factor by neuroendocrine cells under inflammatory conditions...
  52. ncbi Development of rhinovirus study model using organ culture of turbinate mucosa
    Yong Ju Jang
    Department of Otolaryngolgy, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2dong, Songpa Gu, Seoul 138 736, South Korea
    J Virol Methods 125:41-7. 2005
    ..Our results indicate that the air-liquid interface organ culture of turbinate mucosa could serve as an acceptable in vitro model for studying RV infection...
  53. ncbi Comparison of three chromogenic media and enrichment broth media for the detection of methicillin-resistant Staphylococcus aureus from mucocutaneous screening specimens : Comparison of MRSA chromogenic media
    C Nonhoff
    Laboratoire de Référence MRSA Staphylocoques, Service de Microbiologie, Hopital Erasme, Bruxelles, Belgium
    Eur J Clin Microbiol Infect Dis 28:363-9. 2009
    ..In conclusion, all media showed equivalent sensitivities after 18 h of incubation and performed better when enriched before inoculation. MRSA-Screen was more sensitive but less specific than the two other media after 42 h of incubation...
  54. ncbi Better detection of Staphylococcus aureus nasal carriage by use of nylon flocked swabs
    Paul Verhoeven
    GIMAP EA 3064 Group Mucosal Immunity and Pathogens Agents, University of Lyon, 42023 Saint Etienne, France
    J Clin Microbiol 48:4242-4. 2010
    ..The use of flocked swabs improved the number of nasal carriers (P = 0.026), the number of positive specimens (P = 0.01), and the quantity of bacteria in positive samples (P = 0.004)...
  55. ncbi Bronchus- and nasal-associated lymphoid tissues
    John Bienenstock
    McMaster University, Hamilton, ON, Canada
    Immunol Rev 206:22-31. 2005
    ..NALT appears from many studies to be a functionally distinct lymphoid aggregate when compared with BALT and Peyer's patches. It may exist, however, in humans as a diffuse collection of isolated lymphoid follicles...
  56. ncbi Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus
    Hae-Sun Park
    Department of Microbiology, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 171:2532-7. 2003
    ....
  57. ncbi Primary ciliary dyskinesia: diagnostic and phenotypic features
    Peadar G Noone
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 169:459-67. 2004
    ..An increased awareness of the clinical presentation and diagnostic criteria for PCD will help lead to better diagnosis and care for this orphan disease...
  58. ncbi Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
    ..This study was performed to provide additional insight into staphylococcal carriage types...
  59. ncbi Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease?
    R J Salib
    Department of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 33:1629-33. 2003
    ..This review endeavours to outline what is known about the nature of the remodelling response within the upper airway in allergic rhinitis, in addition to highlighting specific areas where further research is warranted...
  60. ncbi Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis
    Heather A Coker
    The Randall Division of Cell and Molecular Biophysics, King's College London, London
    J Allergy Clin Immunol 116:445-52. 2005
    BACKGROUND: IgE antibody-producing B cells are enriched in the nasal mucosa in patients with allergic rhinitis because of local class switching to IgE...
  61. ncbi Combined antiviral-antimediator treatment for the common cold
    Jack M Gwaltney
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Infect Dis 186:147-54. 2002
    ..IFN-alpha2b added to the effectiveness of chlorpheniramine and ibuprofen and was well tolerated...
  62. ncbi The presence of ovarian hormone receptors in the nasal mucosa and their relationship to nasal symptoms
    C M Philpott
    Department of Otorhinolaryngology, Leicester Royal Infirmary, Leicester, United Kingdom
    Rhinology 46:221-5. 2008
    ..There is evidence in the literature showing a link between ovarian hormones and changes to nasal physiology...
  63. ncbi Distribution, chemical coding and origin of nitric oxide synthase-containing nerve fibres in the guinea pig nasal mucosa
    T Kondo
    Department of Anatomy and Histology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Japan
    J Auton Nerv Syst 80:71-9. 2000
    ....
  64. ncbi Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps
    T Ishibashi
    Department of Otolaryngology, Tokyo University Branch Hospital, Japan
    Ann Otol Rhinol Laryngol 107:885-90. 1998
    To examine the potential biologic role of fibroblast growth factors (FGFs) in nasal polyps and nasal mucosa during chronic inflammatory conditions, we investigated messenger RNA (mRNA) expression of three members of the FGF family -- ..
  65. ncbi The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, The State University of New York, 3C41 Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209, USA
    Curr Allergy Asthma Rep 5:472-6. 2005
    ..Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents...
  66. ncbi Th2 immunological inflammation in allergic fungal sinusitis, nonallergic eosinophilic fungal sinusitis, and chronic rhinosinusitis
    A Simon Carney
    Department of Otolaryngology Head and Neck Surgery, Flinders Medical Center, Bedford Park, South Australia 5042, Australia
    Am J Rhinol 20:145-9. 2006
    ..The detailed mucosal Th2 cytological status of NEFS still has not been studied in great depth...
  67. ncbi Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps
    Andrew P Lane
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
    Am J Rhinol 20:138-44. 2006
    ..In this study, we compared sinonasal expression of toll-like receptors (TLRs), complement components, serum amyloid A, and inflammatory genes (chemokines and cytokines) in control subjects and patients undergoing sinus surgery for CRS...
  68. ncbi [Efficacy and safety of mometasone furoate nasal spray in the treatment of sinusitis or acute rhinosinusitis]
    J M Klossek
    Hôpital La Mileterie, Service ORL, 86000 Poitiers, France
    Rev Laryngol Otol Rhinol (Bord) 128:187-92. 2007
    ..Intranasal corticosteroids act on the nasal mucosa to relieve inflammation and its associated symptoms, and may be a useful symptomatic treatment option...
  69. ncbi The role of superantigens in chronic rhinosinusitis with nasal polyps
    Mingming Wang
    Department of Otorhinolaryngology, Shandong Provincial Hospital, Shandong University, Jinan, PR China
    ORL J Otorhinolaryngol Relat Spec 70:97-103. 2008
    ..The objectives of this study are (1) to demonstrate directly the presence of staphylococcal exotoxins in nasal mucosa and sinonasal polyp tissue, and (2) provide indirect evidence of the effect of superantigens on the T cells ..
  70. ncbi Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells
    Murugappan Ramanathan
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21287 0910, USA
    Am J Rhinol 22:115-21. 2008
    ..The relationship between Th2 inflammatory cytokines and the innate immune function of sinonasal epithelial cells (SNECs) has not been explored...
  71. ncbi Epithelial genes in chronic rhinosinusitis with and without nasal polyps
    Sara L Richer
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Rhinol 22:228-34. 2008
    ..This study examines the expression of key epithelial genes implicated in the pathogenesis of other inflammatory disorders for their role in chronic rhinosinusitis (CRS)...
  72. ncbi Chronic rhinosinusitis and recurrent nasal polyps in two children with IgG subclass deficiency and review of the literature
    Sasawan Chinratanapisit
    Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Med Assoc Thai 88:S251-8. 2005
    ..Further study on the direct role of IVIG in NPs will be needed in the future...
  73. ncbi Expression of cyclooxygenase and lipoxygenase enzymes in sinonasal mucosa of patients with cystic fibrosis
    Jonathan M Owens
    Department of Otolaryngology Head and Neck Surgery, University of Colorado, Denver, CO 80045, USA
    Arch Otolaryngol Head Neck Surg 134:825-31. 2008
    ..To evaluate the expression of cyclooxygenase (COX) and lipoxygenase (LO) enzymes in the sinonasal mucosa of patients with cystic fibrosis (CF)...
  74. ncbi Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis
    A Niederfuhr
    Department of Otorhinolaryngology, University Hospital of Ulm, Ulm, Germany
    Allergy 63:1359-67. 2008
    ..The frequency of S. aureus and SASCV in CRS patients and S. aureus-related effects on the local immune response should be prospectively investigated...
  75. ncbi In vivo relationship between collagenase-2 and interleukin-8 but not tumour necrosis factor-alpha in chronic rhinosinusitis with nasal polyposis
    K Kostamo
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    Allergy 60:1275-9. 2005
    ..Remodelling is tightly controlled by matrix metalloproteinases (MMP). Increase of collagenase-2 (MMP-8) expression in the bronchial epithelial cells has been described in asthmatic patients, but it has not been studied in CRSwNP...
  76. ncbi Nasal biomarker profiles in acute and chronic rhinosinusitis
    H Riechelmann
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Clin Exp Allergy 35:1186-91. 2005
    ..Clinical manifestations of rhinosinusitis include acute rhinosinusitis, chronic rhinosinusitis (CRS) with nasal polyps and CRS without polyps...
  77. ncbi Site of origin of nasal polyps: relevance to pathogenesis and management
    A E Andrews
    ENT Department, Royal Surrey County Hospital, Egerton Road, Guildford, United Kingdom
    Rhinology 43:180-4. 2005
    ..In summary, our findings suggest that polyps originate from the middle meatus, and may be found at surgery when undetectable at pre-operative endoscopy...
  78. ncbi Sebaceous metaplasia of the nasal glands
    Masayuki Shintaku
    Pathol Int 55:750-1. 2005
  79. ncbi Does the use of the combined oral contraceptive pill cause changes in the nasal physiology in young women?
    Charlotte R Wolstenholme
    Department of Otorhinolaryngology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
    Am J Rhinol 20:238-40. 2006
    ..Changes in nasal physiology have been observed during pregnancy and the menstrual cycle. The role of female hormones in these changes is unclear. The aim is to investigate the effect of the modern combined oral contraceptive pill (COCP)...
  80. ncbi Up-regulation of the mucosal epidermal growth factor receptor gene in chronic rhinosinusitis and nasal polyposis
    Guo Qiang Ding
    Department of Otorhinolaryngology Head and Neck Surgery, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, China
    Arch Otolaryngol Head Neck Surg 133:1097-103. 2007
    ....
  81. ncbi CT analysis and histopathology of bone remodeling in patients with chronic rhinosinusitis
    Seok Hyun Cho
    Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Haeng-dang-dong 17, Sungdong-gu, Seoul 133-792, Korea
    Otolaryngol Head Neck Surg 135:404-8. 2006
    ..821, P = 0.0001). These findings in CT scans and histopathology were well correlated with each other (r > 0.3, P < 0.05). CONCLUSION: HU may be a useful objective marker of bone remodeling in chronic rhinosinusitis...
  82. ncbi [The role of local factors in the development of acute and chronic rhinosinusitis]
    O A Alimov
    Voen Med Zh 327:42-4. 2006
  83. ncbi Vascular endothelial growth factor and children featuring nasal polyps
    Ko Hsin Hu
    Department of Otorhinolaryngology Head and Neck Surgery, Taoyuan General Hospital, Department of Health, Taoyuan, Taiwan
    Int J Pediatr Otorhinolaryngol 71:23-8. 2007
    ..The aim of this study is to explore the expression of vascular endothelial growth factor within nasal polyps, and the implication of such expression as regards the development of nasal polyps amongst children...
  84. ncbi Chronic rhinosinusitis with glandular hypertrophy
    James N Baraniuk
    Georgetown University Proteomics Laboratory, Washington, DC, USA
    Clin Allergy Immunol 20:121-46. 2007
  85. ncbi Mucosal remodeling in chronic rhinosinusitis
    Ryan M Rehl
    Arizona Sinus Center, Phoenix, Arizona 85006, USA
    Am J Rhinol 21:651-7. 2007
    ..Despite pathophysiologic similarities, mucosal remodeling is well described in asthma but not chronic rhinosinusitis (CRS)...
  86. ncbi Differentiating osteomeatal complex disease and chronic rhinosinusitis from nonallergic rhinitis
    James N Baraniuk
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, D.C, USA
    Clin Allergy Immunol 19:115-46. 2007
  87. ncbi Sinonasal mucociliary clearance in health and disease
    Noam A Cohen
    Division of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Medical Center, 5 Silverstein/Ravdin, 3400 Spruce St, Philadelphia, PA 19104, USA
    Ann Otol Rhinol Laryngol Suppl 196:20-6. 2006
    ..A review of the current understanding of the cellular regulation of respiratory ciliary activity and its contribution to chronic rhinosinusitis is presented...
  88. ncbi Sinonasal epithelial cell expression of toll-like receptor 9 is decreased in chronic rhinosinusitis with polyps
    Murray Ramanathan
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Rhinol 21:110-6. 2007
    ..In this study, primary epithelial cell cultures were analyzed from control subjects and CRSwNP patients to determine the presence and function of TLR9 protein...
  89. ncbi Unusual Corynebacterium mucifaciens isolated from ear and nasal specimens
    Setsuko Morinaka
    Department of Otorhinolaryngology, Kobe Japanpost Hospital, 6 2 43 Kamitsutsui dori, Chuo Ku, Kobe 651 8798, Japan
    Otolaryngol Head Neck Surg 135:392-6. 2006
    ..Corynebacterium mucifaciens was first proposed as a novel Corynebacterium species in 1997. This report describes our experience with the unexpectedly frequent isolation of C mucifaciens...
  90. ncbi Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis
    Claus Bachert
    Upper Airway Research Laboratory, ENT-Department, University Hospital Ghent, Ghent, Belgium
    Clin Allergy Immunol 20:163-75. 2007
  91. ncbi [Effects of irrigating solution of Sihuang on morphology and function of nasal mucosa following surgery for chronic sinusitis and nasal polyps]
    Wei-Qiu Wu
    Department of Otorhinolaryngology, People's Hospital of Nanshan, Shenzhen 518052, China
    Di Yi Jun Yi Da Xue Xue Bao 25:424-7. 2005
    ..different between the two groups, but the postoperative morphological and functional recovery of the nasal mucosa occurred earlier in ISSH than in NS group (P<0.05)...
  92. ncbi Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis
    Michael Weschta
    Department of Otorhinolaryngology Head and Neck Surgery, University of Ulm, Ulm, Germany
    Arch Otolaryngol Head Neck Surg 132:743-7. 2006
    ..To examine the effect of nasal antifungal treatment on eosinophil cationic protein (ECP) and tryptase levels in samples of nasal lavage fluid from patients with chronic rhinosinusitis and nasal polyps...
  93. ncbi Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-alpha responses in primary human nasal epithelial cells
    F Sachse
    Department of Otolaryngology, Head and Neck Surgery, University of Munster, Munster, Germany
    Int Arch Allergy Immunol 145:24-32. 2008
    ..Among others, serine and cysteine proteases have been identified as factors of virulence in S. epidermidis...
  94. ncbi [Revision of the European Position Paper on Rhinosinusitis and Nasal Polyposis (EP3OS) with particular attention to acute and recurrent rhinosinusitis]
    D Passali
    Clinica ORL, , Italy
    Acta Otorhinolaryngol Ital 27:1-21. 2007
  95. ncbi The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis
    Guo Qiang Ding
    Department of Otorhinolaryngology Head and Neck Surgery, Eye and ENT Hospital of Fudan University, Shanghai, China
    Am J Rhinol 21:359-66. 2007
    ..The aim of this study was to investigate the expression of MUC5AC and MUC5B messenger RNAs (mRNAs) and localization of these proteins in human sinus mucosa of chronic rhinosinusitis (CRS) and CRS with nasal polyposis (CRS/NP)...
  96. ncbi Sinonasal surfactant protein A1, A2, and D gene expression in cystic fibrosis: a preliminary report
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Otolaryngol Head Neck Surg 137:34-8. 2007
    ..To measure alterations in SPA1, A2, and D gene expression in various forms of inflammatory chronic rhinosinusitis (CRS)...
  97. ncbi Role of prostaglandin D2 and E2 terminal synthases in chronic rhinosinusitis
    M Okano
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Clin Exp Allergy 36:1028-38. 2006
    ..Prostaglandin (PG)D(2) and E(2), two major cyclooxygenase (COX) products, are generated by PGD(2) synthase (PGDS) and PGE(2) synthase (PGES), respectively, and appear to mediate airway inflammation...
  98. ncbi Chronic rhinosinusitis patients with polyps or polypoid mucosa have a greater burden of illness
    Aleena Banerji
    Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Rhinol 21:19-26. 2007
    ..The aim of this study was to determine whether patients with CRSsNP, CRScNP, and polypoid CRS could be distinguished by clinical features, radiologic extent of disease or use of medications...
  99. ncbi The value of Ems Mineral Salts in the treatment of rhinosinusitis in children. Prospective study on the efficacy of mineral salts versus xylometazoline in the topical nasal treatment of children
    O Michel
    Klinik u Poliklinik für HNO Heilkunde, Klinikum der Universität zu Köln, Kerpenerstr 62, 50924 Köln, Germany
    Int J Pediatr Otorhinolaryngol 69:1359-65. 2005
    ....
  100. ncbi Eosinophilic fungal rhinosinusitis (EFRS): a distinct CT/MRI-entity? A European experience
    S Vlaminck
    Department of Otorhinolaryngology, St Jan General Hospital, Bruges, Belgium
    B-ENT 1:73-82. 2005
    ..To determine the value of radiological features in the diagnosis of Eosinophilic Fungal Rhinosinusitis (EFRS)...
  101. ncbi Neuropathology in rhinosinusitis
    James N Baraniuk
    Division of Rheumatology, Immunology and Allergy, Georgetown University, 3800 Reservoir Road, N W, Washington, DC 20007 2197, USA
    Am J Respir Crit Care Med 171:5-11. 2005
    ..CFS had neural hypersensitivity (pain) but reduced serous cell secretion. HTS nasal provocations identified significant, unique patterns of neural and mucosal dysregulation in each rhinosinusitis syndrome...

Research Grants70

  1. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen Donovan; Fiscal Year: 2009
    ..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
  2. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2009
    ..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
  3. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2010
    ..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
  4. Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal Mucos
    Maureen D Donovan; Fiscal Year: 2010
    ..It is the goal of this research to identify key drug transporters in the nasal mucosa, and to use this information to identify efficient pathways for direct, safe delivery of drugs to the CNS...
  5. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ..tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
  6. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
  7. Human CYP2A and respiratory tract xenobiotic toxicity
    Xinxin Ding; Fiscal Year: 2007
    ..respiratory tract and is much more abundant than CYP2A6, the other functional member of the CYP2A subfamily, in nasal mucosa and lung; (b) heterologously expressed CYP2A13 is highly active in the metabolic activation of several ..
  8. Proteomics of Staphylococcus aureus nasal carriage
    Alexander Cole; Fiscal Year: 2003
    The human nasal mucosa is an accessible and clinically important model for the study of microbial interactions with host defenses...
  9. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2007
    ..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa. An advantage of this route is that it should deliver virus to the entire trigeminal nerve, including the ..
  10. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004
    ..hypothesis that chlipoplexes will deliver effectively the pDNAs without any significant adverse effects in the nasal mucosa and provide significant protection against viral infections...
  11. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2003
    ..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
  12. R01-Williajm - Double-Blind Placebo-Controlled trial of Nicotine Nasal Spray as a
    Jill M Williams; Fiscal Year: 2010
    ..Nicotine Nasal Spray (NNS) differs from other forms of NRT in that nicotine is absorbed rapidly through the nasal mucosa and produces physiological effects that are expected to speed relief of withdrawal and craving...
  13. Nasal carriage of S. aureus: host-pathogen interactions
    Alexander Cole; Fiscal Year: 2007
    ..We hypothesize that 1) the expression of lipocalin-1 is dysregulated in the nasal mucosa of SA carriers, contributing to the progressive colonization of SA, 2) correcting the lipocalin-1 deficiency ..