Genomes and Genes
Summary: The mucous lining of the NASAL CAVITY, including lining of the NOSTRIL (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.
Publications330 found, 100 shown here
- Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutationFrank J Accurso
University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
N Engl J Med 363:1991-2003. 2010..VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro...
- Reclassification of Staphylococcus aureus nasal carriage typesAlex van Belkum
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
J Infect Dis 199:1820-6. 2009..This study was performed to provide additional insight into staphylococcal carriage types...
- Ataluren (PTC124) induces cystic fibrosis transmembrane conductance regulator protein expression and activity in children with nonsense mutation cystic fibrosisIsabelle Sermet-Gaudelus
Hopital Necker Enfants Malades, Paris, France
Am J Respir Crit Care Med 182:1262-72. 2010..Ataluren (PTC124) is an oral drug that permits ribosomes to readthrough premature stop codons in mRNA to produce functional protein...
- kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patientsFernanda Santos de Oliveira
Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ CEP 21045 900, Brazil
Diagn Microbiol Infect Dis 66:361-5. 2010..Viannia) braziliensis DNA and investigate kDNA signatures of parasite populations present in oral and nasal mucosa lesions from mucosal leishmaniasis patients...
- Nasal-associated lymphoid tissue (NALT): frequency and localization in young childrenA S Debertin
Department Legal Medicine, Medical School of Hannover, Hannover, Germany
Clin Exp Immunol 134:503-7. 2003..Clearly in contrast to rodents human NALT was found disseminated in the nasal mucosa with typical morphological features in 38% of all children, mainly in the middle concha, with similar ..
- Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reactionLucas Gomes Patrocinio
State Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Faculty of Medicine, Federal University of Uberlandia, Minas Gerais, Brazil
FEMS Immunol Med Microbiol 44:311-6. 2005..The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary ..
- Cystic fibrosis and survival to 40 years: a study of cystic fibrosis transmembrane conductance regulator functionN J Simmonds
Dept of Cystic Fibrosis, Royal Brompton Hospital, London, SW3 6NP, UK
Eur Respir J 37:1076-82. 2011..5 (80.0-113.5) mmol·L⁻¹; young/mild). Δ Amil is associated with FEV₁ but our findings indicate that long-term survival cannot be explained by residual CFTR function when measurements are taken in later life...
- Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cellsTsuyoshi Ohkuni
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
Toxicol Appl Pharmacol 250:29-38. 2011..The control of TLR3-mediated signaling pathways in HNECs may be important not only in infection by viral dsRNA but also in autoimmune diseases caused by endogenous dsRNA released from necrotic cells...
- Expression of Toll-like receptors in cultured nasal epithelial cellsChih Feng Lin
Department of Otolaryngology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
Acta Otolaryngol 127:395-402. 2007..Considering that the ligand for TLR3 is viral dsRNA, this result is in good accordance with previous reports demonstrating that more differentiated airway epithelial cells have increased resistance to rhinovirus infection...
- Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cellsHenry Yim Wu
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:6038-50. 2008..Our results demonstrate that nasal anti-CD3 induces CD4(+)CD25(-)LAP(+) regulatory T cells that suppress lupus in mice and that it is associated with down-regulation of T cell help for autoantibody production...
- Trigeminal antihyperalgesic effect of intranasal carbon dioxideAlexander Z Tzabazis
Department of Anesthesia, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
Life Sci 87:36-41. 2010..This study investigated the underlying mechanisms of this observation and its potential use to reverse trigeminal pain and hypersensitivity...
- Exposure to cigarette smoke condensate reduces calcium activated chloride channel transport in primary sinonasal epithelial culturesFrank W Virgin
Department of Surgery Division of Otolaryngology, University of Alabama at Birmingham, Alabama 35294, USA
Laryngoscope 120:1465-9. 2010..Because it is not known whether CaCCs are also inhibited by tobacco exposure, the current study was designed to investigate the effect of cigarette smoke condensate (CSC) on CaCC transport...
- Why do we not find polyps in the lungs? Bronchial mucosa as a model in the treatment of polyposisRogério Pezato
Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Belgium
Med Hypotheses 78:468-70. 2012..If the lower and upper airways share a lot of common epithelial structural features so why is the edema in the nasal mucosa able to increase so much the size of the mucosa to the point of developing polyps? The article tries to ..
- Incidental maxillary sinus findings in orthodontic patients: a radiographic analysis using cone-beam computed tomography (CBCT)P Pazera
Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland
Orthod Craniofac Res 14:17-24. 2011..To determine the frequency of incidental maxillary sinus findings using cone-beam computed tomography (CBCT) images made for orthodontic purposes...
- Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosaShimona Gayle
Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
Cell Tissue Res 319:27-36. 2005..P2X5 receptor immunoreactivity was found in the squamous, respiratory and olfactory epithelial cells of the rat nasal mucosa. P2X7 receptor immunoreactivity was also expressed in epithelial cells and colocalised with caspase 9 (an ..
- Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuliThomas Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
Int J Psychophysiol 47:147-58. 2003..g. induced by environmental agents...
- Similarities and differences between smoking-related gene expression in nasal and bronchial epitheliumXiaoling Zhang
Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
Physiol Genomics 41:1-8. 2010..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
- The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigensDong Young Kim
Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
J Immunol 186:4253-62. 2011....
- Intranasal instillation of aflatoxin B(1) in rats: bioactivation in the nasal mucosa and neuronal transport to the olfactory bulbP Larsson
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala
Toxicol Sci 55:383-91. 2000..Inhalation of contaminated dust particles may result in high local exposure of the nasal mucosa. The present study was designed to assess bioactivation and toxicity of AFB(1) in the nasal mucosa after ..
- A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunityTatsuya Fukuiwa
The Immunobiology Vaccine Center, Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
Vaccine 26:4849-59. 2008..These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly...
- Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adultsMeri K Tulic
Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
Lancet 363:1689-97. 2004..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults.
- Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infectionsChristopher Weidenmaier
Cellular and Molecular Microbiology, Medical Microbiology and Hygiene Department, University of Tubingen, Elfriede Aulhorn Strasse 6, 72076 Tubingen, Germany
Nat Med 10:243-5. 2004..WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization...
- Hesperidin stimulates cystic fibrosis transmembrane conductance regulator-mediated chloride secretion and ciliary beat frequency in sinonasal epitheliumChristopher Azbell
Department of Surgery Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, USA
Otolaryngol Head Neck Surg 143:397-404. 2010....
- Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthmaJordi Roca-Ferrer
Immunoallergia Respiratoria Clinica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
J Allergy Clin Immunol 128:66-72.e1. 2011..Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA)...
- Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehydeKun Lu
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, United States
Chem Res Toxicol 24:159-61. 2011..In contrast, exogenous adducts were not detectable in the bone marrow of rats exposed to 15.2 ppm [(13)CD(2)] formaldehyde...
- Anatomical mapping of human herpesvirus reservoirs of infectionTiansheng Chen
Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
Mod Pathol 19:726-37. 2006..CMV was detected in three cases, most commonly in nasal mucosa, trachea, thyroid, intestine, and liver...
- HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitisKen ichi Takano
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
J Histochem Cytochem 53:611-9. 2005..we investigated the expression and function of tight junctions and characterized DCs in the epithelium of nasal mucosa from patients with allergic rhinitis...
- Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airwaysG J Braunstahl
Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Allergy Clin Immunol 107:469-76. 2001..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules...
- Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in miceAna Vila
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Santiago de Compostela, Spain
Eur J Pharm Biopharm 57:123-31. 2004..CS nanoparticles were also labeled with FITC-BSA and their interaction with the rat nasal mucosa examined by confocal laser scanning microcopy (CLSM)...
- Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitisSophie Clement
Department of Pathology and Immunology, University of Geneva, Switzerland
J Infect Dis 192:1023-8. 2005..Intracellular residence may provide a sanctuary for pathogenic bacteria by protecting them from host defense mechanisms and antibiotic treatment during acute, recurrent S. aureus rhinosinusitis...
- Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine modelAdam C Schaffer
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Infect Immun 74:2145-53. 2006..aureus nasal colonization in humans, which in turn may diminish the risk of staphylococcal infection. As targets for vaccine development and antimicrobial intervention are assessed, rodent nasal colonization models may be invaluable...
- The air-conditioning capacity of the human noseSara Naftali
Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Ann Biomed Eng 33:545-53. 2005..During a moderate breathing effort, about 11% reduction in the efficacy of nasal air-conditioning capacity was observed...
- Intranasal delivery: physicochemical and therapeutic aspectsHenry R Costantino
Nastech Pharmaceutical Company, Inc, Bothell, WA 98021, USA
Int J Pharm 337:1-24. 2007..The nasal mucosa offers numerous benefits as a target issue for drug delivery, such as a large surface area for delivery, rapid ..
- Human nasal mucosa contains tissue-resident immunologically responsive mesenchymal stromal cellsMark Jakob
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Germany
Stem Cells Dev 19:635-44. 2010..Here, we report for the first time on the isolation and characterization of multipotent nasal mucosa-derived mesenchymal stromal cells (nm-MSC)...
- Rhinovirus infection-induced alteration of tight junction and adherens junction components in human nasal epithelial cellsNam Kyung Yeo
Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea
Laryngoscope 120:346-52. 2010..The objective of this study was to investigate changes in the components of TJs (ZO-1, occluding, and claudin-1) and AJs (E-cadherin) after RV infection in cultured nasal epithelial cells...
- Lipopolysaccharide decreases connexin 43 expression on nasal epithelial cells in vitroTe Huei Yeh
Department of Otolaryngology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Acta Otolaryngol 125:1091-6. 2005..55+/-0.05 ng/microg protein (n=8). Expression of the Cx43:beta-actin ratio decreased in a time- and dose-dependent fashion (10(-3)-10(-1) mg/ml LPS)...
- The nasal mucosa contains a large spectrum of human papillomavirus types from the Betapapillomavirus and Gammapapillomavirus generaOla Forslund
Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, Malmo, Sweden
J Infect Dis 208:1335-41. 2013..Human papillomavirus (HPV) types from the Betapapillomavirus and Gammapapillomavirus genera are common at cutaneous sites. The aim of this study was to analyze the prevalence of these HPV types in oral and nasal samples...
- Biological markers in nasal secretionsH Riechelmann
Dept of Otorhinolaryngology, University of Ulm, Medical School, Prittwitzstr 43, 89075 Ulm, Germany
Eur Respir J 21:600-5. 2003..The considerable variability of reported analyte concentrations in nasal secretions mainly results from different sampling techniques. To collect nasal secretions, samplers are considered superior to nasal lavage techniques...
- Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigenDai Mizuno
Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan
J Immunol 176:1122-30. 2006..the expression of MHC class II, CD40, and CD86 molecules in the CD11c-positive cells isolated from the nasal mucosa, but not the expression of cells from the lungs or spleens...
- Rat strain difference in histology and expression of Th1- and Th2-related cytokines in nasal mucosa after short-term formaldehyde inhalationRyoichi Ohtsuka
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
Exp Toxicol Pathol 54:287-91. 2003Changes in histology and Th1- and Th2-related cytokines expression in nasal mucosa were examined in Brown Norway (BN) and Fischer 344 (F344) rats after 5-day inhalation of 1% formaldehyde aerosol...
- Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulationJun ichi Koizumi
Department of Otolaryngology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
Mol Pharmacol 74:432-42. 2008The epithelium of upper respiratory tissues such as human nasal mucosa forms a continuous barrier via tight junctions, which is thought to be regulated in part through a protein kinase C (PKC) signaling pathway...
- Sinonasal epithelial cell expression of toll-like receptor 9 is decreased in chronic rhinosinusitis with polypsMurray Ramanathan
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Rhinol 21:110-6. 2007..In this study, primary epithelial cell cultures were analyzed from control subjects and CRSwNP patients to determine the presence and function of TLR9 protein...
- Transforming growth factor-beta gene expression studies in nasal mucosal biopsies in naturally occurring allergic rhinitisRami J Salib
Allergy and Inflammation Research, Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, UK
Ann R Coll Surg Engl 89:563-73. 2007....
- CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitorDanieli B Salinas
Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
Am J Physiol Lung Cell Mol Physiol 287:L936-43. 2004..In pigs, CFTR may not be responsible for Cl- channel-dependent nasal PDs. These results have important implications for interpreting nasal PDs in terms of CFTR function in animal models of CFTR activation and inhibition...
- Transient receptor potential vanilloid type 4 channel expression in chronic rhinosinusitisGeeta Bhargave
Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Am J Rhinol 22:7-12. 2008..Thus, the goal of this study was to establish the expression pattern of TRPV4 in human sinonasal mucosa and determine whether expression is altered in chronic rhinosinusitis (CRS)...
- Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptorM Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Neuroscience 148:744-56. 2007..SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch clamping, retrograde-labeling, ..
- The expression of osteopontin and its association with Clara cell 10 kDa protein in allergic rhinitisY Liu
Departments of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Clin Exp Allergy 40:1632-41. 2010..At this time, it is not known whether OPN is involved in allergic rhinitis (AR) or if there is any association between CC10 and OPN in AR...
- A preliminary report on the effects of paclitaxel-impregnated stents on sheep nasal mucosaBrian W Herrmann
Department of Otolaryngology, Washington University, School of Medicine, St Louis, Missouri 63110 1077, USA
Am J Rhinol 18:119-24. 2004..Paclitaxel (Taxol), which has recognized antiscarring effects, may be incorporated via a polymeric formulation into standard rubber stents. The impact of topically applied paclitaxel on the morphology of the nasal mucosa is unknown.
- Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patientsHeather A Coker
The Randall Centre, King s College London, London, United Kingdom
J Immunol 171:5602-10. 2003..We have analyzed IgE V(H) region sequences expressed in the nasal mucosa of patients suffering from allergic rhinitis...
- Antioxidant effects of quercetin and coenzyme Q10 in mini organ cultures of human nasal mucosa cellsMaximilian Reiter
Department of Otorhinolaryngology Head and Neck Surgery, Grosshadern Clinic, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Anticancer Res 29:33-9. 2009..The aim of this study was to investigate antioxidant effects of quercetin and CoQ10 on mini organ cultures (MOCs) of human nasal mucosa.
- The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cellsFiona M Roche
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
Microbiology 149:2759-67. 2003..These results suggest that SasG, Pls and AAP bind to the same as-yet-unidentified receptor on the surface of nasal epithelial cells. In addition, expression of SasG, like Pls, reduced adherence of S. aureus to fibronectin and fibrinogen...
- Mucosal antibody response induced with a nasal virosome-based influenza vaccineP Durrer
Berna Biotech Ltd, Research and Development, Rehhagstr 79, CH 3018, Bern, Switzerland
Vaccine 21:4328-34. 2003..Its potential to offer a high level of mucosal protection, not provided by conventional parenteral vaccination, could play a significant role in preventing morbidity and mortality associated with influenza...
- Microarray cDNA to identify inflammatory genes in nasal polyposisClaudia R Figueiredo
Department of Otorhinolaryngology, Head and Neck Surgery, Federal University of Sao Paulo, Brazil
Am J Rhinol 21:231-5. 2007..The objective of this study was to investigate the spectrum of inflammatory gene expression in patients with nasal polyposis...
- Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequencyNoam A Cohen
Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Laryngoscope 119:2269-74. 2009..The present study investigates the consequences of cigarette smoke exposure on ciliary function and transepithelial chloride (Cl(-)) secretion, a major determinant of ASL...
- Mucosal [SIgA] and serum [IgG] immunologic responses in the community after a single intra-nasal immunization with a new inactivated trivalent influenza vaccineEvgenia Greenbaum
Department of Virology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
Vaccine 20:1232-9. 2002..The new vaccine was safe, without side-effects, and offered reasonable protection after one dose. It could thus play an important role in increasing enrollment into immunization programs...
- Regulation of ciliary beat frequency by the nitric oxide signaling pathway in mouse nasal and tracheal epithelial cellsJian Jiao
Key Laboratory of Otolaryngology, Head and Neck Surgery Ministry of Education, Beijing Institute of Otolaryngology, China
Exp Cell Res 317:2548-53. 2011..Our purpose was to investigate the role of the nitric oxide (NO) signaling pathway in the regulation of ciliary beat frequency (CBF) in mouse nasal and tracheal epithelial cells...
- Replication characteristics of porcine reproductive and respiratory syndrome virus (PRRSV) European subtype 1 (Lelystad) and subtype 3 (Lena) strains in nasal mucosa and cells of the monocytic lineage: indications for the use of new receptors of PRRSV (LeIlias S Frydas
Laboratory of Virology, Department of Virology, Immunology and Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B 9820, Belgium
Vet Res 44:73. 2013..This points to differences in the pathogenesis. In the present study, a new polarized nasal mucosa explant system was used to study the invasion of the low virulent subtype 1 PRRSV strain Lelystad (LV) and the ..
- Measurement of airway ion transport assists the diagnosis of cystic fibrosisPeter G Middleton
Cystic Fibrosis Unit, Ludwig Engel Centre for Respiratory Research, Westmead Millennium Institute, University of Sydney at Westmead, Westmead, NSW, Australia
Pediatr Pulmonol 45:789-95. 2010..Avoidance of the squamous epithelium remains an important consideration for those performing and interpreting nasal PD responses...
- Normal function of the cystic fibrosis conductance regulator protein can be associated with homozygous (Delta)F508 mutationIsabelle Sermet-Gaudelus
INSERM U 467, Faculte Necker, 156 rue de Vaugirard, 75015 Paris, France
Pediatr Res 52:628-35. 2002..This cAMP-dependent Cl(-) conductance detected in homozygous NCC could be due to a residual CFTR activity and may explain the mild phenotypes observed in some (Delta)F508 homozygous patients...
- Equine alphaherpesviruses (EHV-1 and EHV-4) differ in their efficiency to infect mononuclear cells during early steps of infection in nasal mucosal explantsAnnelies P Vandekerckhove
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 152:21-8. 2011..The inefficient capacity of EHV-4 to infect mononuclear cells explains in part the rarity of EHV-4-induced viremia, and subsequently, the rarity of EHV-4-induced abortion or EHM...
- Nasal deposition and clearance in man: comparison of a bidirectional powder device and a traditional liquid spray pumpPer Gisle Djupesland
1 CSO, OptiNose AS, Oslo, Norway
J Aerosol Med Pulm Drug Deliv 25:280-9. 2012..Yardley, PA, USA) to that of liquid aerosol administered via a traditional hand-actuated liquid spray pump (Rexam SP270, Rexam Pharma, France)...
- Epithelial tight junction alterations in nasal polyposisG Aaron Rogers
Department of Otolaryngology, Emory University, Atlanta, GA, USA
Int Forum Allergy Rhinol 1:50-4. 2011..Our hypothesis is that exposure of nasal and respiratory epithelium to inflammatory cytokines results in the altered expression of specific TJPs...
- Increased brain radioactivity by intranasal P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gelsAna Paula Perez
Programa de Nanomedicinas, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal, Buenos Aires, Argentina
Int J Nanomedicine 7:1373-85. 2012....
- Antigen-specific activities of CD8+ T cells in the nasal mucosa of patients with nasal allergyShuqi Qiu
Shenzhen ENT Institute, Shenzheng, China
Asian Pac J Allergy Immunol 30:107-13. 2012..Antigen specific CD8+ T cells play a critical role in the induction of chronic inflammation. This study aims to investigate the role of antigen specific CD8+ T cells in the pathogenesis of chronic AR...
- Biofilms in chronic rhinosinusitis with nasal polypsThiago Freire Pinto Bezerra
Department of Otorhinolaryngology and Ophthalmology, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
Otolaryngol Head Neck Surg 144:612-6. 2011..1) Evaluate the presence of biofilms in patients with chronic sinusitis with nasal polyps (CRSwNP) and (2) investigate the association of biofilm presence and CRSwNP...
- The pathogenesis of nasal polyposis by immunoglobulin E and interleukin-5 is completed by transforming growth factor-beta1Andor Hirschberg
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Laryngoscope 113:120-4. 2003..The study was designed to examine the suggested roles of IgE, interleukin-5 (IL-5), and transforming growth factor-beta1 (TGF-beta1) in the pathogenesis of nasal polyposis...
- Nasal potential difference measurements to assess CFTR ion channel activitySteven M Rowe
Department of Medicine, University of Alabama, Birmingham, AL 35294 0006, USA
Methods Mol Biol 741:69-86. 2011..This chapter will elaborate on the electrophysiological principles behind the test, the equipment required, the methods, and the analysis of the data...
- Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissueXiangdong Wang
Upper Airways Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
PLoS ONE 7:e39875. 2012..However the mechanisms underlying the initiation of damage and/or invasion of the nasal mucosa by S. aureus are not clearly understood. The aim of this study was to investigate the interaction between S...
- A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cellsTomoyuki Masaki
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
Mol Biol Cell 22:2144-56. 2011..The control of this pathway in HNECs may be useful not only for prevention of replication and budding of RSV, but also in therapy for RSV-induced respiratory pathogenesis...
- Nrf2 expression modifies influenza A entry and replication in nasal epithelial cellsMatthew J Kesic
Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7127, USA
Free Radic Biol Med 51:444-53. 2011..Taken together, these data indicate potential mechanisms by which Nrf2-dependent gene expression regulates susceptibility to influenza in human epithelial cells...
- Follow-up of Staphylococcus aureus nasal carriage after 8 years: redefining the persistent carrier stateM F VandenBergh
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Microbiol 37:3133-40. 1999..aureus nasal carriage is a unique characteristic of a fraction of the population, and the attribute "persistent" should be confined to those individuals for whom serial nasal swab specimen cultures consistently yield S. aureus...
- BSE infectivity in the absence of detectable PrP(Sc) accumulation in the tongue and nasal mucosa of terminally diseased cattleAnne Balkema-Buschmann
Friedrich Loeffler Institut, Institute for Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald Insel Riems, Germany
J Gen Virol 92:467-76. 2011..biochemical methods, we were, for the first time, able to detect BSE infectivity in the tongue and in the nasal mucosa of terminally diseased BSE field cases as well as experimentally challenged cattle by transgenic-mouse bioassay...
- The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitisS M Keh
Imperial College London, London, UK
Rhinology 49:453-7. 2011..TRPM8 nerve fibres were compared with those expressing other TRP receptors including TRPV1 (capsaicin and heat receptor), and TRPA1 (mechano-cold receptor)...
- Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosaSarah Glorieux
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
PLoS ONE 6:e22160. 2011..Remarkably, interactions of herpesviruses with human mucosa, the locus of infection, remain poorly understood and the underlying mechanisms in stromal infection remain controversial...
- Effects of nasal mask leak and heated humidification on nasal mucosa in the therapy with nasal continuous positive airway pressure (nCPAP)Yvonne Fischer
Department of Otorhinolaryngology, Laboratory for Sleep Research and Sleep Medicine, University of Ulm, Frauensteige 12, 89075 Ulm, Germany
Sleep Breath 12:353-7. 2008..nCPAP with heated humidifier is able to compensate the dehydration effects induced by nCPAP therapy with NML by increasing the aH at the anterior turbinate area to the levels observed during breathing with nCPAP alone...
- Alterations in gene expression of complement components in chronic rhinosinusitisRodney J Schlosser
Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Rhinol Allergy 24:21-5. 2010....
- Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitisQ T Dinh
Department of Internal Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
Clin Exp Allergy 35:1443-8. 2005..The present study aimed to explore H1R and H2R expression in complex tissues of the nasal mucosa of perennial allergic rhinitis (PAR).
- Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigsJ Plevkova
Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Sklabinska 26, Martin 03753, Slovak Republic
Respir Physiol Neurobiol 142:225-35. 2004..We conclude that stimulation of nasal afferent nerves with capsaicin enhances experimentally-induced cough. Our results suggest that afferent inputs from the nose interact with the cough reflex pathways in a manner that enhances cough...
- The rostral ventrolateral medulla mediates the sympathoactivation produced by chemical stimulation of the rat nasal mucosaP F McCulloch
Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
J Physiol 516:471-84. 1999..2. Stimulation of the nasal mucosa increased splanchnic sympathetic nerve discharge (SND), elevated arterial blood pressure (ABP), raised heart ..
- Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compoundMelvin E Andersen
Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 118:716-31. 2010....
- Activation of olfactory and trigeminal cortical areas following stimulation of the nasal mucosa with low concentrations of S(-)-nicotine vapor--an fMRI study on chemosensory perceptionJessica Albrecht
Department of Neuroradiology, Ludwig Maximilians University Munich, Munich, Germany
Hum Brain Mapp 30:699-710. 2009Applied to the nasal mucosa in low concentrations, nicotine vapor evokes odorous sensations (mediated by the olfactory system) whereas at higher concentrations nicotine vapor additionally produces burning and stinging sensations in the ..
- Histological study of Trichosomoides nasalis (Nematoda: Trichinelloidea) in the nasal cavities of the murid Arvicanthis niloticus, with associated pathologyM Diagne
Departement de Biologie Animale, Faculte des Sciences, Universite Cheikh Anta Diop, Dakar, Senegal
Parasite 11:351-8. 2004..infected with Trichosomoides nasalis shows that the female worms reside in the epithelial monolayer of the nasal mucosa of the posterior and median cavities. Eggs laid by T...
- Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollenYoshiaki Kitamura
Department of Otolaryngology, University of Tokushima Graduate School, Japan
Acta Otolaryngol 132:434-8. 2012..gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in ..
- Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposureBenjamin C Moeller
Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599 7431, United States
Chem Res Toxicol 24:162-4. 2011The presence of endogenous and exogenous N(2)-hydroxymethyl-dG adducts in DNA from the nasal mucosa and bone marrow of cynomolgus macaques exposed to 1.9 and 6...
- Prevalence of pathologic findings in the maxillary sinus in cone-beam computerized tomographyLutz Ritter
Interdisciplinary Outpatient Department of Oral Surgery and Implantology, Department of Craniomaxillofacial and Plastic Surgery, University of Cologne, Germany
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:634-40. 2011..The aim of this study was to assess the prevalence of pathologic findings in the maxillary sinus by using cone-beam computerized tomography (CBCT)...
- Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explantsAnnelies P Vandekerckhove
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
J Gen Virol 91:2019-28. 2010..Finally, this study showed that equine respiratory explants are a valuable and reproducible model to study EHV-1 neurovirulence in vitro, thereby reducing the need for horses as experimental animals...
- Histological and immunological observations of bacterial and allergic chronic rhinosinusitis in the mouseHeng Wang
Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Am J Rhinol 22:343-8. 2008..The purpose of this study was to elucidate histological and immunologic features of mouse models of bacterial chronic rhinosinusitis (BCRS) and allergic chronic rhinosinusitis (ACRS)...
- Measurement of nasal potential difference in young children with an equivocal sweat test following newborn screening for cystic fibrosisIsabelle Sermet-Gaudelus
CRCM and INSERM U845, Hopital Necker, Faculte de Medecine Necker, Universite Rene Descartes, Paris, France
Thorax 65:539-44. 2010....
- Gene expression for carbonic anhydrase isoenzymes in human nasal mucosaAlice S Tarun
University of California, San Francisco, Medicine, San Francisco, CA, USA
Chem Senses 28:621-9. 2003..CA enzymatic activity has been demonstrated in the human nasal mucosa using enzyme histochemical methods, but no systematic study of nasal mucosal CA isoenzyme gene expression has ..
- Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfactionKai Zhao
Bioengineering Department, University of Pennsylvania, RM 120 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
Chem Senses 29:365-79. 2004....
- Potential role of abnormal ion transport in the pathogenesis of chronic sinusitisKenji Dejima
Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Arch Otolaryngol Head Neck Surg 132:1352-62. 2006..To create well-differentiated cultures of normal and chronic sinusitis paranasal sinus epithelial cells and to compare their electrophysiologic properties...
- Nasal and paranasal sinus anatomy and physiologyFuad M Baroody
Department of Surgery, Section of Otolaryngology Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
Clin Allergy Immunol 19:1-21. 2007
- Nasal resistance and allergic inflammation depend on allergen typeMatteo Gelardi
Dipartimento di Oculistica e Otorinolaringoiatria, Universita di Bari, Bari, Italy
Int Arch Allergy Immunol 141:384-9. 2006..Allergic rhinitis is characterized by inflammatory cell infiltrate and increased nasal airflow resistance...
- Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosaG J Braunstahl
Department of Otorhinolaryngology, Erasmus University Medical Center Rotterdam, The Netherlands
Am J Respir Crit Care Med 164:858-65. 2001..05) in allergic rhinitis patients after SBP. In the nasal mucosa, the numbers of MC(C) and MC(TC) cells decreased significantly, whereas the numbers of [BB1(+)] cells increased ..
- Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitroStephan Hackenberg
Department of Oto Rhino Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
Toxicol In Vitro 25:657-63. 2011..The current study focused on the cyto- and genotoxicity of ZnO-NPs in comparison to ZnO powder in primary human nasal mucosa cells cultured in the air-liquid interface...
- Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polypsZ Liu
Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Allergy 62:999-1006. 2007....
- Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehydeFanxue Meng
US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA
Regul Toxicol Pharmacol 57:274-83. 2010This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR)...
- Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenzaIlona Jaspers
Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
Am J Respir Cell Mol Biol 43:368-75. 2010....
- Evaluation of MRSA Select, a new chromogenic medium for the detection of nasal carriage of methicillin-resistant Staphylococcus aureusSana Ben Nsira
Service de Microbiologie, Hôpital Côte de Nacre, Universite de Caen, 14033 Caen Cedex, France
Int J Antimicrob Agents 27:561-4. 2006..By contrast, on the single criterion of the colour of colonies for MRSA positivity, the specificity and sensitivity of MRSA Select were high (99.8% and 99%, respectively)...
- Forkhead box P3+ T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposisT Liu
Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
Clin Exp Immunol 163:59-64. 2011..The present study aims to examine the regulatory T cells (T(reg) ) in nasal mucosa of patients with allergic rhinitis (AR) and nasal polyposis (NP)...
- Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccineTakashi Hirano
Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
Immunol Lett 107:131-9. 2006..These kinetic antibody patterns and cellular responses may provide useful information regarding to effective mucosal vaccines against NTHi infections...
- Selectivity and Permeation in the Human Voltage-gated Proton Channel, hHv1Susan M E Smith; Fiscal Year: 2013..In addition to its effect on ROS, hHV1 has other functions in basophils, nasal mucosa, sperm, and B cells that implicate it in male fertility, allergic responses, and such diseases as cystic ..
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2013..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
- Partnership for Primary Care ImagingStephen A Boppart; Fiscal Year: 2013..multiple tissue sites commonly examined during primary care outpatient exams including the eyes, ears, oral and nasal mucosa, skin, and cervix...
- The Role of PcpA in the Mechanism of Virulence and Protective Immunity.MELISSA MARIE WALKER; Fiscal Year: 2013..is expressed in invasive disease in the lung, blood and organs;but is not expressed during colonization of the nasal mucosa. It is known that PcpA is a virulence factor in the lung and blood but not in nasal colonization...
- T cell immunity to influenza virus in the aged nasal mucosaBas Baaten; Fiscal Year: 2013..LAIV is administered via the nasal mucosa and replicates only in the upper respiratory tract, and the NALT could play a crucial role in the induction of ..
- Leica LMD 7000 Laser Capture Microdissection MicroscopeSiegfried Janz; Fiscal Year: 2013..in a newly developed pig model of human cystic fibrosis;Maureen Donovan studies transporter proteins in the nasal mucosa for improved drug delivery systems to the brain;and David Soll evaluates factors of pathogenicity in the yeast, ..
- Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal PathogenesisRituparna Das; Fiscal Year: 2013..the immune system with the bacterium will allow us to appreciate how pneumococcus exists as a colonizer in the nasal mucosa but causes destructive invasive disease in the lungs...
- A NOVEL METHOD TO TREAT CHRONIC PAINSATHYANARAYANA N MURTHY; Fiscal Year: 2013..Following frequent and prolonged administration of the formulation, the nasal mucosa, olfactory mucosa, olfactory bulb, brain and spinal cord will be isolated and subjected to histological ..
- Lipid Effector Molecules of Innate Immunity: Antimicrobial Cholesteryl EstersEdith Porter; Fiscal Year: 2013..We will validate our results with primary epithelial cells established from sino-nasal mucosa obtained as surgical excess material, and confirm key regulators with siRNA methodology...
- WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in ADNeelima B Chauhan; Fiscal Year: 2012..by virtue of its endocytic uptake preference, but will also facilitate passive diffusion of 3A1 due to its nasal mucosa-like biochemical composition, maximizing immunotherapeutic efficacy of intranasal passive immunization, to be ..
- Development of a Mouse Trigeminal Pain ModelANDREW RUSSO; Fiscal Year: 2009..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa. An advantage of this route is that it should deliver virus to the entire trigeminal nerve, including the ..
- The Cardiopulmonary Effects of Particulate ExposureDavid C Christiani; Fiscal Year: 2013..arterial stiffness;and 3) epigenetic changes, measured by global methylation in DNA from peripheral blood and nasal mucosa brushings of exposed individuals...
- Nasal solitary chemosensory cells linking irritation to inflammationMarco Tizzano; Fiscal Year: 2013..b>Nasal mucosa irritation also activates inflammatory and local immune responses aimed to protect the nasal epithelium and ..
- Prevention of Allergic Rhinitis with Topical Immunomodulating AntibodiesRandall M Goldblum; Fiscal Year: 2011..can provide an effective "barrier" between an inhaled allergen and patient's IgE antibodies in the nasal mucosa. Further, these results will lay the ground work for Phase II studies, in which we will;a) produce and test ..
- Mechanisms of prion transportRichard A Bessen; Fiscal Year: 2013..the pathway of prion movement in neurons, studies will investigate the spread of prions between the brain and nasal mucosa within olfactory receptor neurons...
- Civamide Nasal Spray for the Treatment of Postherpetic Neuralgia of the TrigeminaScott B Phillips; Fiscal Year: 2013..3,4,5 The [TN] also has superficial nerve endings in the nasal mucosa, which are the targets of Civamide Nasal Spray...
- R01-Williajm - Double-Blind Placebo-Controlled trial of Nicotine Nasal Spray as aJill M Williams; Fiscal Year: 2010..Nicotine Nasal Spray (NNS) differs from other forms of NRT in that nicotine is absorbed rapidly through the nasal mucosa and produces physiological effects that are expected to speed relief of withdrawal and craving...
- Vaginal Immunity After Intranasal Listeria VaccinationFred Frankel; Fiscal Year: 2009..Our own preliminary studies confirm this, and show that the nasal mucosa is even more sensitive than the gut to infection and translocation by Lm...
- PYRIDINE--ENZYME INDUCTION, METABOLISM, AND TOXICITYMelissa Runge Morris; Fiscal Year: 1991..provide important information on the induction of cytochrome P-450 in extrahepatic tissues, particularly the nasal mucosa and lung, and the effects of induction on xenobiotic metabolism and toxicity in these tissues...
- INTERPLAY OF ALLERGIC RHINITIS AND NASAL HUMIDIFICATIONRobert Naclerio; Fiscal Year: 1999..chamber to test the hypotheses that: a) the induction of allergic inflammation reduces the ability of the nasal mucosa to warm and humidify CDA; b) the nasal response to CDA of individuals with perennial allergic rhinitis exceeds ..
- TOXIC RESPONSES OF NASAL MUCOSA TO INHALED IRRITANTSJohn Morris; Fiscal Year: 2000..Substance P exerts a variety of effects in human and rodent nasal mucosa including vasodilation and increased blood flow, increased vascular permeability leading to edemagenesis, and ..
- CHILDHOOD IMMUNIZATION FOR DENTAL CARIESDEBRA TRANTOLO; Fiscal Year: 2000..Adhesion to the nasal mucosa increases the transit time of the microparticles and facilitates absorption of these GTF-containing ..
- Nasal Contour Pack for EpistaxisPAUL BUREK; Fiscal Year: 2002..Desiccated sponges are solid and immalleable during insertion, often damaging the nasal mucosa. RBDC proposes to develop and test the Nasal Contour Pack (C-Pack)...
- METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESStephen Hecht; Fiscal Year: 2003..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
- Nasal Contour Pack for EpistaxisKENNETH WEIL; Fiscal Year: 2004..Desiccated sponges are solid and immalleable during insertion, often damaging the nasal mucosa. RBDC developed and tested the Pillow Pac on an anatomical model in Phase I...
- Chlipoplex Nanoparticle Prophylactics for RSV InfectionShyam Mohapatra; Fiscal Year: 2004..hypothesis that chlipoplexes will deliver effectively the pDNAs without any significant adverse effects in the nasal mucosa and provide significant protection against viral infections...
- EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASELawrence Schwartz; Fiscal Year: 2001..tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
- FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAYIgor Kratskin; Fiscal Year: 2003..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
- Proteomics of Staphylococcus aureus nasal carriageAlexander Cole; Fiscal Year: 2003The human nasal mucosa is an accessible and clinically important model for the study of microbial interactions with host defenses...
- PREVENTION OF NASAL CAVITY TUMORS BY CASTRATIONPARVIZ POUR; Fiscal Year: 1990..activities of P-450 isozymes, particularly those with sex hormone-dependent functions, will be investigated in nasal mucosa and livers of these rats...
- EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGENRobert Naclerio; Fiscal Year: 1990..the nasal secretions for the presence of inflammatory mediators and cells before and after exposing the nasal mucosa of volunteers to pollen antigens, this proposal plans to improve the human model of allergic rhinitis in order ..
- EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGENRobert Naclerio; Fiscal Year: 1993..the nasal secretions for the presence of inflammatory mediators and cells before and after exposing the nasal mucosa of volunteers to pollen antigens, this proposal plans to improve the human model of allergic rhinitis in order ..
- ROLE OF HUMAN NASAL MUCOSAL P450 IN HEAD AND NECK CANCERXinxin Ding; Fiscal Year: 2001..To identify and characterize P450 gene expression in adult and fetal human nasal mucosa. The cellular distribution and developmental expression of various P450 isoforms known to be active in the ..
- NITROSAMINE ACTIVATION AND EXTRAHEPATIC P450SSharon Murphy; Fiscal Year: 1999..Preliminary studies with human P450s, rat nasal mucosa and rat esophageal microsomes, indicate that P450 2A enzymes play an important role in the activation of ..
- DEVELOPMENT OF TRANSNASAL KETAMINE FOR BREAKTHROUGH PAINFRED MERMELESTEIN; Fiscal Year: 2000..does not induce changes in blood pressure or heart rate and does not demonstrate evidence of toxicity to the nasal mucosa following repetitive administration...
- NERVES & NEUROTROPHINS IN ALLERGIC AIRWAY DISEASEAlvin Sanico; Fiscal Year: 2004..in AR patients compared to healthy individuals, suggesting perturbations in the neural components of the nasal mucosa. The principal objective of this proposal is to begin to discern the interrelation between the immune and ..
- Nasal carriage of S. aureus: host-pathogen interactionsAlexander M Cole; Fiscal Year: 2010..We hypothesize that 1) the expression of lipocalin-1 is dysregulated in the nasal mucosa of SA carriers, contributing to the progressive colonization of SA, 2) correcting the lipocalin-1 deficiency ..
- NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUSTomas Ganz; Fiscal Year: 2001..the search for the underlying defect in mucosal immunity: (1) identify the specific topographic areas of the nasal mucosa in which S. aureus is carried; (2) characterize the differences in mucus composition, anti-S...
- ESTROGEN REGULATION IN CHOLINERGIC SYSTEMSFarida Sohrabji; Fiscal Year: 2001..Due to its proximity and connections with the nasal mucosa, bulb neurons are especially vulnerable to environmental toxins and viruses, as are its efferent fibers that ..
- SCOR: CHRONIC DISEASES OF THE AIRWAYSSolbert Permutt; Fiscal Year: 1991..Project I, The Response of the Nasal Mucosa to Hyperventilation with Cold, Dry Air, uses the human nose as a possible model of what is going on in the ..
- Immunopathology of the Nasal Mucosa in SarcoidosisJeffrey Berman; Fiscal Year: 2005..Furthermore this work should provide the basis for additional studies pertaining to sarcoidosis. (End of Abstract) ..
- ANTI-ID AB VACCINE FOR HUMAN RESPIRATORY SYNCYTIAL VIRUSJOHN SLACK; Fiscal Year: 1992..anti-Id) vaccination, on the other hand, seems ideally suited to generate passive immunity in the nasal mucosa of at risk infants...
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2009..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- Temporal Integration in Nasal LateralizationPaul Wise; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLORMary Beth Genter; Fiscal Year: 2002....
- Extracellular matrix in chloracetanilide carcinogenesisMary Beth Genter; Fiscal Year: 2004..abstract_text> ..
- Sphingolipid signaling in olfactory mucosaMary Beth Genter; Fiscal Year: 2004..abstract_text> ..
- Cytokines on Olfactory Receptor Neuron FunctionAndrew Lane; Fiscal Year: 2006..Additional bench research will be performed in the laboratory of Dr. Schleimer, an established scientist with expertise in airway inflammation and cytokine modulation of cell function. ..
- RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITISFuad Baroody; Fiscal Year: 2003..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
- Mechanisms of prion transportRICHARD BESSEN; Fiscal Year: 2008..the pathway of prion movement in neurons, studies will investigate the spread of prions between the brain and nasal mucosa within olfactory receptor neurons...
- Sixth International Respiratory Syncytial Virus SymposiumANN FALSEY; Fiscal Year: 2007..abstract_text> ..
- THE CPA: SOMATIC AND AUTONOMIC SYSTEMSW Panneton; Fiscal Year: 2004..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
- CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITYKohtaro Fujihashi; Fiscal Year: 2005..The seminal findings which have emanated from this grant effort since 1982 will again remain focused on the cellular and molecular events required for induction of mucosal immunity or oral tolerance in the GI tract. ..
- Dermatopharmacokinetics: In Vivo Analysis of SolventsKarla Thrall; Fiscal Year: 2005..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
- NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGINGKohtaro Fujihashi; Fiscal Year: 2010....
- Reflexes and Supraesophageal Consequences of Reflux DiseaseBrendan J Canning; Fiscal Year: 2010..This research may also help identify novel therapeutic strategies for treating both GERD and chronic cough. ..
- ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSESKohtaro Fujihashi; Fiscal Year: 2010..4) Determination of the precise mechanism for cross-talk between Ad-FL-induced salivary DCs, B-1 B cells and yS T cells for salivary S-lgA Ab responses. ..
- NOX-mediated proton secretion by airwaysHorst Fischer; Fiscal Year: 2006..This will help develop novel therapeutical targets for the treatment of airway acidity and inflammatory airway diseases. ..
- Airborne Transmission of Viruses in Human Subjects: Efficacy of Face MasksWerner Bischoff; Fiscal Year: 2007..This cnowledge is paramount in view of the inevitable viral pandemics. ..
- CONTROL OF EPIDEMIC INFLUENZAPEDRO PIEDRA; Fiscal Year: 2007..abstract_text> ..
- Regulation of ENaC by Serine Proteases in AirwaysScott Donaldson; Fiscal Year: 2006..The PI's long term goals are to provide important new insights into the basic elements of airway defense, CF lung disease, and to bring these findings to the development of novel therapies for CF lung disease. ..