nasal mucosa

Summary

Summary: The mucous lining of the NASAL CAVITY, including lining of the NOSTRIL (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.

Top Publications

  1. pmc Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    Frank J Accurso
    University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
    N Engl J Med 363:1991-2003. 2010
  2. ncbi Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
  3. ncbi Ataluren (PTC124) induces cystic fibrosis transmembrane conductance regulator protein expression and activity in children with nonsense mutation cystic fibrosis
    Isabelle Sermet-Gaudelus
    Hopital Necker Enfants Malades, Paris, France
    Am J Respir Crit Care Med 182:1262-72. 2010
  4. ncbi kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patients
    Fernanda Santos de Oliveira
    Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ CEP 21045 900, Brazil
    Diagn Microbiol Infect Dis 66:361-5. 2010
  5. pmc Nasal-associated lymphoid tissue (NALT): frequency and localization in young children
    A S Debertin
    Department Legal Medicine, Medical School of Hannover, Hannover, Germany
    Clin Exp Immunol 134:503-7. 2003
  6. ncbi Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction
    Lucas Gomes Patrocinio
    State Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Faculty of Medicine, Federal University of Uberlandia, Minas Gerais, Brazil
    FEMS Immunol Med Microbiol 44:311-6. 2005
  7. ncbi Cystic fibrosis and survival to 40 years: a study of cystic fibrosis transmembrane conductance regulator function
    N J Simmonds
    Dept of Cystic Fibrosis, Royal Brompton Hospital, London, SW3 6NP, UK
    Eur Respir J 37:1076-82. 2011
  8. ncbi Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells
    Tsuyoshi Ohkuni
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Toxicol Appl Pharmacol 250:29-38. 2011
  9. ncbi Expression of Toll-like receptors in cultured nasal epithelial cells
    Chih Feng Lin
    Department of Otolaryngology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    Acta Otolaryngol 127:395-402. 2007
  10. pmc Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:6038-50. 2008

Detail Information

Publications330 found, 100 shown here

  1. pmc Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    Frank J Accurso
    University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
    N Engl J Med 363:1991-2003. 2010
    ..VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro...
  2. ncbi Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
    ..This study was performed to provide additional insight into staphylococcal carriage types...
  3. ncbi Ataluren (PTC124) induces cystic fibrosis transmembrane conductance regulator protein expression and activity in children with nonsense mutation cystic fibrosis
    Isabelle Sermet-Gaudelus
    Hopital Necker Enfants Malades, Paris, France
    Am J Respir Crit Care Med 182:1262-72. 2010
    ..Ataluren (PTC124) is an oral drug that permits ribosomes to readthrough premature stop codons in mRNA to produce functional protein...
  4. ncbi kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patients
    Fernanda Santos de Oliveira
    Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ CEP 21045 900, Brazil
    Diagn Microbiol Infect Dis 66:361-5. 2010
    ..Viannia) braziliensis DNA and investigate kDNA signatures of parasite populations present in oral and nasal mucosa lesions from mucosal leishmaniasis patients...
  5. pmc Nasal-associated lymphoid tissue (NALT): frequency and localization in young children
    A S Debertin
    Department Legal Medicine, Medical School of Hannover, Hannover, Germany
    Clin Exp Immunol 134:503-7. 2003
    ..Clearly in contrast to rodents human NALT was found disseminated in the nasal mucosa with typical morphological features in 38% of all children, mainly in the middle concha, with similar ..
  6. ncbi Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction
    Lucas Gomes Patrocinio
    State Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Faculty of Medicine, Federal University of Uberlandia, Minas Gerais, Brazil
    FEMS Immunol Med Microbiol 44:311-6. 2005
    ..The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary ..
  7. ncbi Cystic fibrosis and survival to 40 years: a study of cystic fibrosis transmembrane conductance regulator function
    N J Simmonds
    Dept of Cystic Fibrosis, Royal Brompton Hospital, London, SW3 6NP, UK
    Eur Respir J 37:1076-82. 2011
    ..5 (80.0-113.5) mmol·L⁻¹; young/mild). Δ Amil is associated with FEV₁ but our findings indicate that long-term survival cannot be explained by residual CFTR function when measurements are taken in later life...
  8. ncbi Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells
    Tsuyoshi Ohkuni
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Toxicol Appl Pharmacol 250:29-38. 2011
    ..The control of TLR3-mediated signaling pathways in HNECs may be important not only in infection by viral dsRNA but also in autoimmune diseases caused by endogenous dsRNA released from necrotic cells...
  9. ncbi Expression of Toll-like receptors in cultured nasal epithelial cells
    Chih Feng Lin
    Department of Otolaryngology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    Acta Otolaryngol 127:395-402. 2007
    ..Considering that the ligand for TLR3 is viral dsRNA, this result is in good accordance with previous reports demonstrating that more differentiated airway epithelial cells have increased resistance to rhinovirus infection...
  10. pmc Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:6038-50. 2008
    ..Our results demonstrate that nasal anti-CD3 induces CD4(+)CD25(-)LAP(+) regulatory T cells that suppress lupus in mice and that it is associated with down-regulation of T cell help for autoantibody production...
  11. pmc Trigeminal antihyperalgesic effect of intranasal carbon dioxide
    Alexander Z Tzabazis
    Department of Anesthesia, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
    Life Sci 87:36-41. 2010
    ..This study investigated the underlying mechanisms of this observation and its potential use to reverse trigeminal pain and hypersensitivity...
  12. pmc Exposure to cigarette smoke condensate reduces calcium activated chloride channel transport in primary sinonasal epithelial cultures
    Frank W Virgin
    Department of Surgery Division of Otolaryngology, University of Alabama at Birmingham, Alabama 35294, USA
    Laryngoscope 120:1465-9. 2010
    ..Because it is not known whether CaCCs are also inhibited by tobacco exposure, the current study was designed to investigate the effect of cigarette smoke condensate (CSC) on CaCC transport...
  13. ncbi Why do we not find polyps in the lungs? Bronchial mucosa as a model in the treatment of polyposis
    Rogério Pezato
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Belgium
    Med Hypotheses 78:468-70. 2012
    ..If the lower and upper airways share a lot of common epithelial structural features so why is the edema in the nasal mucosa able to increase so much the size of the mucosa to the point of developing polyps? The article tries to ..
  14. ncbi Incidental maxillary sinus findings in orthodontic patients: a radiographic analysis using cone-beam computed tomography (CBCT)
    P Pazera
    Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland
    Orthod Craniofac Res 14:17-24. 2011
    ..To determine the frequency of incidental maxillary sinus findings using cone-beam computed tomography (CBCT) images made for orthodontic purposes...
  15. ncbi Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa
    Shimona Gayle
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Cell Tissue Res 319:27-36. 2005
    ..P2X5 receptor immunoreactivity was found in the squamous, respiratory and olfactory epithelial cells of the rat nasal mucosa. P2X7 receptor immunoreactivity was also expressed in epithelial cells and colocalised with caspase 9 (an ..
  16. ncbi Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuli
    Thomas Hummel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
    Int J Psychophysiol 47:147-58. 2003
    ..g. induced by environmental agents...
  17. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
    ..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
  18. ncbi The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens
    Dong Young Kim
    Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Immunol 186:4253-62. 2011
    ....
  19. ncbi Intranasal instillation of aflatoxin B(1) in rats: bioactivation in the nasal mucosa and neuronal transport to the olfactory bulb
    P Larsson
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala
    Toxicol Sci 55:383-91. 2000
    ..Inhalation of contaminated dust particles may result in high local exposure of the nasal mucosa. The present study was designed to assess bioactivation and toxicity of AFB(1) in the nasal mucosa after ..
  20. pmc A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity
    Tatsuya Fukuiwa
    The Immunobiology Vaccine Center, Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Vaccine 26:4849-59. 2008
    ..These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly...
  21. ncbi Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults
    Meri K Tulic
    Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
    Lancet 363:1689-97. 2004
    ..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults.
  22. ncbi Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections
    Christopher Weidenmaier
    Cellular and Molecular Microbiology, Medical Microbiology and Hygiene Department, University of Tubingen, Elfriede Aulhorn Strasse 6, 72076 Tubingen, Germany
    Nat Med 10:243-5. 2004
    ..WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization...
  23. pmc Hesperidin stimulates cystic fibrosis transmembrane conductance regulator-mediated chloride secretion and ciliary beat frequency in sinonasal epithelium
    Christopher Azbell
    Department of Surgery Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, USA
    Otolaryngol Head Neck Surg 143:397-404. 2010
    ....
  24. ncbi Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma
    Jordi Roca-Ferrer
    Immunoallergia Respiratoria Clinica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Allergy Clin Immunol 128:66-72.e1. 2011
    ..Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA)...
  25. pmc Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde
    Kun Lu
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    Chem Res Toxicol 24:159-61. 2011
    ..In contrast, exogenous adducts were not detectable in the bone marrow of rats exposed to 15.2 ppm [(13)CD(2)] formaldehyde...
  26. ncbi Anatomical mapping of human herpesvirus reservoirs of infection
    Tiansheng Chen
    Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
    Mod Pathol 19:726-37. 2006
    ..CMV was detected in three cases, most commonly in nasal mucosa, trachea, thyroid, intestine, and liver...
  27. ncbi HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis
    Ken ichi Takano
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Histochem Cytochem 53:611-9. 2005
    ..we investigated the expression and function of tight junctions and characterized DCs in the epithelium of nasal mucosa from patients with allergic rhinitis...
  28. ncbi Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways
    G J Braunstahl
    Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Allergy Clin Immunol 107:469-76. 2001
    ..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules...
  29. ncbi Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice
    Ana Vila
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Santiago de Compostela, Spain
    Eur J Pharm Biopharm 57:123-31. 2004
    ..CS nanoparticles were also labeled with FITC-BSA and their interaction with the rat nasal mucosa examined by confocal laser scanning microcopy (CLSM)...
  30. ncbi Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis
    Sophie Clement
    Department of Pathology and Immunology, University of Geneva, Switzerland
    J Infect Dis 192:1023-8. 2005
    ..Intracellular residence may provide a sanctuary for pathogenic bacteria by protecting them from host defense mechanisms and antibiotic treatment during acute, recurrent S. aureus rhinosinusitis...
  31. pmc Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model
    Adam C Schaffer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 74:2145-53. 2006
    ..aureus nasal colonization in humans, which in turn may diminish the risk of staphylococcal infection. As targets for vaccine development and antimicrobial intervention are assessed, rodent nasal colonization models may be invaluable...
  32. ncbi The air-conditioning capacity of the human nose
    Sara Naftali
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Ann Biomed Eng 33:545-53. 2005
    ..During a moderate breathing effort, about 11% reduction in the efficacy of nasal air-conditioning capacity was observed...
  33. ncbi Intranasal delivery: physicochemical and therapeutic aspects
    Henry R Costantino
    Nastech Pharmaceutical Company, Inc, Bothell, WA 98021, USA
    Int J Pharm 337:1-24. 2007
    ..The nasal mucosa offers numerous benefits as a target issue for drug delivery, such as a large surface area for delivery, rapid ..
  34. ncbi Human nasal mucosa contains tissue-resident immunologically responsive mesenchymal stromal cells
    Mark Jakob
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Germany
    Stem Cells Dev 19:635-44. 2010
    ..Here, we report for the first time on the isolation and characterization of multipotent nasal mucosa-derived mesenchymal stromal cells (nm-MSC)...
  35. ncbi Rhinovirus infection-induced alteration of tight junction and adherens junction components in human nasal epithelial cells
    Nam Kyung Yeo
    Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea
    Laryngoscope 120:346-52. 2010
    ..The objective of this study was to investigate changes in the components of TJs (ZO-1, occluding, and claudin-1) and AJs (E-cadherin) after RV infection in cultured nasal epithelial cells...
  36. ncbi Lipopolysaccharide decreases connexin 43 expression on nasal epithelial cells in vitro
    Te Huei Yeh
    Department of Otolaryngology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Acta Otolaryngol 125:1091-6. 2005
    ..55+/-0.05 ng/microg protein (n=8). Expression of the Cx43:beta-actin ratio decreased in a time- and dose-dependent fashion (10(-3)-10(-1) mg/ml LPS)...
  37. ncbi The nasal mucosa contains a large spectrum of human papillomavirus types from the Betapapillomavirus and Gammapapillomavirus genera
    Ola Forslund
    Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, Malmo, Sweden
    J Infect Dis 208:1335-41. 2013
    ..Human papillomavirus (HPV) types from the Betapapillomavirus and Gammapapillomavirus genera are common at cutaneous sites. The aim of this study was to analyze the prevalence of these HPV types in oral and nasal samples...
  38. ncbi Biological markers in nasal secretions
    H Riechelmann
    Dept of Otorhinolaryngology, University of Ulm, Medical School, Prittwitzstr 43, 89075 Ulm, Germany
    Eur Respir J 21:600-5. 2003
    ..The considerable variability of reported analyte concentrations in nasal secretions mainly results from different sampling techniques. To collect nasal secretions, samplers are considered superior to nasal lavage techniques...
  39. ncbi Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen
    Dai Mizuno
    Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan
    J Immunol 176:1122-30. 2006
    ..the expression of MHC class II, CD40, and CD86 molecules in the CD11c-positive cells isolated from the nasal mucosa, but not the expression of cells from the lungs or spleens...
  40. ncbi Rat strain difference in histology and expression of Th1- and Th2-related cytokines in nasal mucosa after short-term formaldehyde inhalation
    Ryoichi Ohtsuka
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Exp Toxicol Pathol 54:287-91. 2003
    Changes in histology and Th1- and Th2-related cytokines expression in nasal mucosa were examined in Brown Norway (BN) and Fischer 344 (F344) rats after 5-day inhalation of 1% formaldehyde aerosol...
  41. ncbi Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation
    Jun ichi Koizumi
    Department of Otolaryngology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Mol Pharmacol 74:432-42. 2008
    The epithelium of upper respiratory tissues such as human nasal mucosa forms a continuous barrier via tight junctions, which is thought to be regulated in part through a protein kinase C (PKC) signaling pathway...
  42. ncbi Sinonasal epithelial cell expression of toll-like receptor 9 is decreased in chronic rhinosinusitis with polyps
    Murray Ramanathan
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Rhinol 21:110-6. 2007
    ..In this study, primary epithelial cell cultures were analyzed from control subjects and CRSwNP patients to determine the presence and function of TLR9 protein...
  43. pmc Transforming growth factor-beta gene expression studies in nasal mucosal biopsies in naturally occurring allergic rhinitis
    Rami J Salib
    Allergy and Inflammation Research, Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, UK
    Ann R Coll Surg Engl 89:563-73. 2007
    ....
  44. ncbi CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor
    Danieli B Salinas
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Am J Physiol Lung Cell Mol Physiol 287:L936-43. 2004
    ..In pigs, CFTR may not be responsible for Cl- channel-dependent nasal PDs. These results have important implications for interpreting nasal PDs in terms of CFTR function in animal models of CFTR activation and inhibition...
  45. ncbi Transient receptor potential vanilloid type 4 channel expression in chronic rhinosinusitis
    Geeta Bhargave
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 22:7-12. 2008
    ..Thus, the goal of this study was to establish the expression pattern of TRPV4 in human sinonasal mucosa and determine whether expression is altered in chronic rhinosinusitis (CRS)...
  46. ncbi Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor
    M Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Neuroscience 148:744-56. 2007
    ..SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch clamping, retrograde-labeling, ..
  47. pmc The expression of osteopontin and its association with Clara cell 10 kDa protein in allergic rhinitis
    Y Liu
    Departments of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Clin Exp Allergy 40:1632-41. 2010
    ..At this time, it is not known whether OPN is involved in allergic rhinitis (AR) or if there is any association between CC10 and OPN in AR...
  48. ncbi A preliminary report on the effects of paclitaxel-impregnated stents on sheep nasal mucosa
    Brian W Herrmann
    Department of Otolaryngology, Washington University, School of Medicine, St Louis, Missouri 63110 1077, USA
    Am J Rhinol 18:119-24. 2004
    ..Paclitaxel (Taxol), which has recognized antiscarring effects, may be incorporated via a polymeric formulation into standard rubber stents. The impact of topically applied paclitaxel on the morphology of the nasal mucosa is unknown.
  49. ncbi Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients
    Heather A Coker
    The Randall Centre, King s College London, London, United Kingdom
    J Immunol 171:5602-10. 2003
    ..We have analyzed IgE V(H) region sequences expressed in the nasal mucosa of patients suffering from allergic rhinitis...
  50. ncbi Antioxidant effects of quercetin and coenzyme Q10 in mini organ cultures of human nasal mucosa cells
    Maximilian Reiter
    Department of Otorhinolaryngology Head and Neck Surgery, Grosshadern Clinic, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Anticancer Res 29:33-9. 2009
    ..The aim of this study was to investigate antioxidant effects of quercetin and CoQ10 on mini organ cultures (MOCs) of human nasal mucosa.
  51. ncbi The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cells
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 149:2759-67. 2003
    ..These results suggest that SasG, Pls and AAP bind to the same as-yet-unidentified receptor on the surface of nasal epithelial cells. In addition, expression of SasG, like Pls, reduced adherence of S. aureus to fibronectin and fibrinogen...
  52. ncbi Mucosal antibody response induced with a nasal virosome-based influenza vaccine
    P Durrer
    Berna Biotech Ltd, Research and Development, Rehhagstr 79, CH 3018, Bern, Switzerland
    Vaccine 21:4328-34. 2003
    ..Its potential to offer a high level of mucosal protection, not provided by conventional parenteral vaccination, could play a significant role in preventing morbidity and mortality associated with influenza...
  53. ncbi Microarray cDNA to identify inflammatory genes in nasal polyposis
    Claudia R Figueiredo
    Department of Otorhinolaryngology, Head and Neck Surgery, Federal University of Sao Paulo, Brazil
    Am J Rhinol 21:231-5. 2007
    ..The objective of this study was to investigate the spectrum of inflammatory gene expression in patients with nasal polyposis...
  54. ncbi Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency
    Noam A Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Laryngoscope 119:2269-74. 2009
    ..The present study investigates the consequences of cigarette smoke exposure on ciliary function and transepithelial chloride (Cl(-)) secretion, a major determinant of ASL...
  55. ncbi Mucosal [SIgA] and serum [IgG] immunologic responses in the community after a single intra-nasal immunization with a new inactivated trivalent influenza vaccine
    Evgenia Greenbaum
    Department of Virology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Vaccine 20:1232-9. 2002
    ..The new vaccine was safe, without side-effects, and offered reasonable protection after one dose. It could thus play an important role in increasing enrollment into immunization programs...
  56. ncbi Regulation of ciliary beat frequency by the nitric oxide signaling pathway in mouse nasal and tracheal epithelial cells
    Jian Jiao
    Key Laboratory of Otolaryngology, Head and Neck Surgery Ministry of Education, Beijing Institute of Otolaryngology, China
    Exp Cell Res 317:2548-53. 2011
    ..Our purpose was to investigate the role of the nitric oxide (NO) signaling pathway in the regulation of ciliary beat frequency (CBF) in mouse nasal and tracheal epithelial cells...
  57. pmc Replication characteristics of porcine reproductive and respiratory syndrome virus (PRRSV) European subtype 1 (Lelystad) and subtype 3 (Lena) strains in nasal mucosa and cells of the monocytic lineage: indications for the use of new receptors of PRRSV (Le
    Ilias S Frydas
    Laboratory of Virology, Department of Virology, Immunology and Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B 9820, Belgium
    Vet Res 44:73. 2013
    ..This points to differences in the pathogenesis. In the present study, a new polarized nasal mucosa explant system was used to study the invasion of the low virulent subtype 1 PRRSV strain Lelystad (LV) and the ..
  58. ncbi Measurement of airway ion transport assists the diagnosis of cystic fibrosis
    Peter G Middleton
    Cystic Fibrosis Unit, Ludwig Engel Centre for Respiratory Research, Westmead Millennium Institute, University of Sydney at Westmead, Westmead, NSW, Australia
    Pediatr Pulmonol 45:789-95. 2010
    ..Avoidance of the squamous epithelium remains an important consideration for those performing and interpreting nasal PD responses...
  59. ncbi Normal function of the cystic fibrosis conductance regulator protein can be associated with homozygous (Delta)F508 mutation
    Isabelle Sermet-Gaudelus
    INSERM U 467, Faculte Necker, 156 rue de Vaugirard, 75015 Paris, France
    Pediatr Res 52:628-35. 2002
    ..This cAMP-dependent Cl(-) conductance detected in homozygous NCC could be due to a residual CFTR activity and may explain the mild phenotypes observed in some (Delta)F508 homozygous patients...
  60. ncbi Equine alphaherpesviruses (EHV-1 and EHV-4) differ in their efficiency to infect mononuclear cells during early steps of infection in nasal mucosal explants
    Annelies P Vandekerckhove
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Microbiol 152:21-8. 2011
    ..The inefficient capacity of EHV-4 to infect mononuclear cells explains in part the rarity of EHV-4-induced viremia, and subsequently, the rarity of EHV-4-induced abortion or EHM...
  61. ncbi Nasal deposition and clearance in man: comparison of a bidirectional powder device and a traditional liquid spray pump
    Per Gisle Djupesland
    1 CSO, OptiNose AS, Oslo, Norway
    J Aerosol Med Pulm Drug Deliv 25:280-9. 2012
    ..Yardley, PA, USA) to that of liquid aerosol administered via a traditional hand-actuated liquid spray pump (Rexam SP270, Rexam Pharma, France)...
  62. ncbi Epithelial tight junction alterations in nasal polyposis
    G Aaron Rogers
    Department of Otolaryngology, Emory University, Atlanta, GA, USA
    Int Forum Allergy Rhinol 1:50-4. 2011
    ..Our hypothesis is that exposure of nasal and respiratory epithelium to inflammatory cytokines results in the altered expression of specific TJPs...
  63. pmc Increased brain radioactivity by intranasal P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels
    Ana Paula Perez
    Programa de Nanomedicinas, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal, Buenos Aires, Argentina
    Int J Nanomedicine 7:1373-85. 2012
    ....
  64. ncbi Antigen-specific activities of CD8+ T cells in the nasal mucosa of patients with nasal allergy
    Shuqi Qiu
    Shenzhen ENT Institute, Shenzheng, China
    Asian Pac J Allergy Immunol 30:107-13. 2012
    ..Antigen specific CD8+ T cells play a critical role in the induction of chronic inflammation. This study aims to investigate the role of antigen specific CD8+ T cells in the pathogenesis of chronic AR...
  65. ncbi Biofilms in chronic rhinosinusitis with nasal polyps
    Thiago Freire Pinto Bezerra
    Department of Otorhinolaryngology and Ophthalmology, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Otolaryngol Head Neck Surg 144:612-6. 2011
    ..1) Evaluate the presence of biofilms in patients with chronic sinusitis with nasal polyps (CRSwNP) and (2) investigate the association of biofilm presence and CRSwNP...
  66. ncbi The pathogenesis of nasal polyposis by immunoglobulin E and interleukin-5 is completed by transforming growth factor-beta1
    Andor Hirschberg
    Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Laryngoscope 113:120-4. 2003
    ..The study was designed to examine the suggested roles of IgE, interleukin-5 (IL-5), and transforming growth factor-beta1 (TGF-beta1) in the pathogenesis of nasal polyposis...
  67. pmc Nasal potential difference measurements to assess CFTR ion channel activity
    Steven M Rowe
    Department of Medicine, University of Alabama, Birmingham, AL 35294 0006, USA
    Methods Mol Biol 741:69-86. 2011
    ..This chapter will elaborate on the electrophysiological principles behind the test, the equipment required, the methods, and the analysis of the data...
  68. pmc Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissue
    Xiangdong Wang
    Upper Airways Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 7:e39875. 2012
    ..However the mechanisms underlying the initiation of damage and/or invasion of the nasal mucosa by S. aureus are not clearly understood. The aim of this study was to investigate the interaction between S...
  69. pmc A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells
    Tomoyuki Masaki
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mol Biol Cell 22:2144-56. 2011
    ..The control of this pathway in HNECs may be useful not only for prevention of replication and budding of RSV, but also in therapy for RSV-induced respiratory pathogenesis...
  70. pmc Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells
    Matthew J Kesic
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7127, USA
    Free Radic Biol Med 51:444-53. 2011
    ..Taken together, these data indicate potential mechanisms by which Nrf2-dependent gene expression regulates susceptibility to influenza in human epithelial cells...
  71. pmc Follow-up of Staphylococcus aureus nasal carriage after 8 years: redefining the persistent carrier state
    M F VandenBergh
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Microbiol 37:3133-40. 1999
    ..aureus nasal carriage is a unique characteristic of a fraction of the population, and the attribute "persistent" should be confined to those individuals for whom serial nasal swab specimen cultures consistently yield S. aureus...
  72. ncbi BSE infectivity in the absence of detectable PrP(Sc) accumulation in the tongue and nasal mucosa of terminally diseased cattle
    Anne Balkema-Buschmann
    Friedrich Loeffler Institut, Institute for Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald Insel Riems, Germany
    J Gen Virol 92:467-76. 2011
    ..biochemical methods, we were, for the first time, able to detect BSE infectivity in the tongue and in the nasal mucosa of terminally diseased BSE field cases as well as experimentally challenged cattle by transgenic-mouse bioassay...
  73. ncbi The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitis
    S M Keh
    Imperial College London, London, UK
    Rhinology 49:453-7. 2011
    ..TRPM8 nerve fibres were compared with those expressing other TRP receptors including TRPV1 (capsaicin and heat receptor), and TRPA1 (mechano-cold receptor)...
  74. pmc Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 6:e22160. 2011
    ..Remarkably, interactions of herpesviruses with human mucosa, the locus of infection, remain poorly understood and the underlying mechanisms in stromal infection remain controversial...
  75. ncbi Effects of nasal mask leak and heated humidification on nasal mucosa in the therapy with nasal continuous positive airway pressure (nCPAP)
    Yvonne Fischer
    Department of Otorhinolaryngology, Laboratory for Sleep Research and Sleep Medicine, University of Ulm, Frauensteige 12, 89075 Ulm, Germany
    Sleep Breath 12:353-7. 2008
    ..nCPAP with heated humidifier is able to compensate the dehydration effects induced by nCPAP therapy with NML by increasing the aH at the anterior turbinate area to the levels observed during breathing with nCPAP alone...
  76. ncbi Alterations in gene expression of complement components in chronic rhinosinusitis
    Rodney J Schlosser
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Rhinol Allergy 24:21-5. 2010
    ....
  77. ncbi Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis
    Q T Dinh
    Department of Internal Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Exp Allergy 35:1443-8. 2005
    ..The present study aimed to explore H1R and H2R expression in complex tissues of the nasal mucosa of perennial allergic rhinitis (PAR).
  78. ncbi Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigs
    J Plevkova
    Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Sklabinska 26, Martin 03753, Slovak Republic
    Respir Physiol Neurobiol 142:225-35. 2004
    ..We conclude that stimulation of nasal afferent nerves with capsaicin enhances experimentally-induced cough. Our results suggest that afferent inputs from the nose interact with the cough reflex pathways in a manner that enhances cough...
  79. pmc The rostral ventrolateral medulla mediates the sympathoactivation produced by chemical stimulation of the rat nasal mucosa
    P F McCulloch
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Physiol 516:471-84. 1999
    ..2. Stimulation of the nasal mucosa increased splanchnic sympathetic nerve discharge (SND), elevated arterial blood pressure (ABP), raised heart ..
  80. ncbi Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound
    Melvin E Andersen
    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 118:716-31. 2010
    ....
  81. ncbi Activation of olfactory and trigeminal cortical areas following stimulation of the nasal mucosa with low concentrations of S(-)-nicotine vapor--an fMRI study on chemosensory perception
    Jessica Albrecht
    Department of Neuroradiology, Ludwig Maximilians University Munich, Munich, Germany
    Hum Brain Mapp 30:699-710. 2009
    Applied to the nasal mucosa in low concentrations, nicotine vapor evokes odorous sensations (mediated by the olfactory system) whereas at higher concentrations nicotine vapor additionally produces burning and stinging sensations in the ..
  82. ncbi Histological study of Trichosomoides nasalis (Nematoda: Trichinelloidea) in the nasal cavities of the murid Arvicanthis niloticus, with associated pathology
    M Diagne
    Departement de Biologie Animale, Faculte des Sciences, Universite Cheikh Anta Diop, Dakar, Senegal
    Parasite 11:351-8. 2004
    ..infected with Trichosomoides nasalis shows that the female worms reside in the epithelial monolayer of the nasal mucosa of the posterior and median cavities. Eggs laid by T...
  83. ncbi Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen
    Yoshiaki Kitamura
    Department of Otolaryngology, University of Tokushima Graduate School, Japan
    Acta Otolaryngol 132:434-8. 2012
    ..gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in ..
  84. pmc Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure
    Benjamin C Moeller
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599 7431, United States
    Chem Res Toxicol 24:162-4. 2011
    The presence of endogenous and exogenous N(2)-hydroxymethyl-dG adducts in DNA from the nasal mucosa and bone marrow of cynomolgus macaques exposed to 1.9 and 6...
  85. ncbi Prevalence of pathologic findings in the maxillary sinus in cone-beam computerized tomography
    Lutz Ritter
    Interdisciplinary Outpatient Department of Oral Surgery and Implantology, Department of Craniomaxillofacial and Plastic Surgery, University of Cologne, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:634-40. 2011
    ..The aim of this study was to assess the prevalence of pathologic findings in the maxillary sinus by using cone-beam computerized tomography (CBCT)...
  86. ncbi Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explants
    Annelies P Vandekerckhove
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Gen Virol 91:2019-28. 2010
    ..Finally, this study showed that equine respiratory explants are a valuable and reproducible model to study EHV-1 neurovirulence in vitro, thereby reducing the need for horses as experimental animals...
  87. ncbi Histological and immunological observations of bacterial and allergic chronic rhinosinusitis in the mouse
    Heng Wang
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Rhinol 22:343-8. 2008
    ..The purpose of this study was to elucidate histological and immunologic features of mouse models of bacterial chronic rhinosinusitis (BCRS) and allergic chronic rhinosinusitis (ACRS)...
  88. ncbi Measurement of nasal potential difference in young children with an equivocal sweat test following newborn screening for cystic fibrosis
    Isabelle Sermet-Gaudelus
    CRCM and INSERM U845, Hopital Necker, Faculte de Medecine Necker, Universite Rene Descartes, Paris, France
    Thorax 65:539-44. 2010
    ....
  89. ncbi Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa
    Alice S Tarun
    University of California, San Francisco, Medicine, San Francisco, CA, USA
    Chem Senses 28:621-9. 2003
    ..CA enzymatic activity has been demonstrated in the human nasal mucosa using enzyme histochemical methods, but no systematic study of nasal mucosal CA isoenzyme gene expression has ..
  90. ncbi Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction
    Kai Zhao
    Bioengineering Department, University of Pennsylvania, RM 120 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Chem Senses 29:365-79. 2004
    ....
  91. ncbi Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis
    Kenji Dejima
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Arch Otolaryngol Head Neck Surg 132:1352-62. 2006
    ..To create well-differentiated cultures of normal and chronic sinusitis paranasal sinus epithelial cells and to compare their electrophysiologic properties...
  92. ncbi Nasal and paranasal sinus anatomy and physiology
    Fuad M Baroody
    Department of Surgery, Section of Otolaryngology Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin Allergy Immunol 19:1-21. 2007
  93. ncbi Nasal resistance and allergic inflammation depend on allergen type
    Matteo Gelardi
    Dipartimento di Oculistica e Otorinolaringoiatria, Universita di Bari, Bari, Italy
    Int Arch Allergy Immunol 141:384-9. 2006
    ..Allergic rhinitis is characterized by inflammatory cell infiltrate and increased nasal airflow resistance...
  94. ncbi Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa
    G J Braunstahl
    Department of Otorhinolaryngology, Erasmus University Medical Center Rotterdam, The Netherlands
    Am J Respir Crit Care Med 164:858-65. 2001
    ..05) in allergic rhinitis patients after SBP. In the nasal mucosa, the numbers of MC(C) and MC(TC) cells decreased significantly, whereas the numbers of [BB1(+)] cells increased ..
  95. ncbi Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro
    Stephan Hackenberg
    Department of Oto Rhino Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Toxicol In Vitro 25:657-63. 2011
    ..The current study focused on the cyto- and genotoxicity of ZnO-NPs in comparison to ZnO powder in primary human nasal mucosa cells cultured in the air-liquid interface...
  96. ncbi Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polyps
    Z Liu
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Allergy 62:999-1006. 2007
    ....
  97. ncbi Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
    Fanxue Meng
    US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA
    Regul Toxicol Pharmacol 57:274-83. 2010
    This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR)...
  98. pmc Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenza
    Ilona Jaspers
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 43:368-75. 2010
    ....
  99. ncbi Evaluation of MRSA Select, a new chromogenic medium for the detection of nasal carriage of methicillin-resistant Staphylococcus aureus
    Sana Ben Nsira
    Service de Microbiologie, Hôpital Côte de Nacre, Universite de Caen, 14033 Caen Cedex, France
    Int J Antimicrob Agents 27:561-4. 2006
    ..By contrast, on the single criterion of the colour of colonies for MRSA positivity, the specificity and sensitivity of MRSA Select were high (99.8% and 99%, respectively)...
  100. pmc Forkhead box P3+ T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposis
    T Liu
    Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
    Clin Exp Immunol 163:59-64. 2011
    ..The present study aims to examine the regulatory T cells (T(reg) ) in nasal mucosa of patients with allergic rhinitis (AR) and nasal polyposis (NP)...
  101. ncbi Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine
    Takashi Hirano
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
    Immunol Lett 107:131-9. 2006
    ..These kinetic antibody patterns and cellular responses may provide useful information regarding to effective mucosal vaccines against NTHi infections...

Research Grants62

  1. Selectivity and Permeation in the Human Voltage-gated Proton Channel, hHv1
    Susan M E Smith; Fiscal Year: 2013
    ..In addition to its effect on ROS, hHV1 has other functions in basophils, nasal mucosa, sperm, and B cells that implicate it in male fertility, allergic responses, and such diseases as cystic ..
  2. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..A subset of the trigeminocardiac reflex is the diving reflex. Stimulation of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% ..
  3. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..multiple tissue sites commonly examined during primary care outpatient exams including the eyes, ears, oral and nasal mucosa, skin, and cervix...
  4. The Role of PcpA in the Mechanism of Virulence and Protective Immunity.
    MELISSA MARIE WALKER; Fiscal Year: 2013
    ..is expressed in invasive disease in the lung, blood and organs;but is not expressed during colonization of the nasal mucosa. It is known that PcpA is a virulence factor in the lung and blood but not in nasal colonization...
  5. T cell immunity to influenza virus in the aged nasal mucosa
    Bas Baaten; Fiscal Year: 2013
    ..LAIV is administered via the nasal mucosa and replicates only in the upper respiratory tract, and the NALT could play a crucial role in the induction of ..
  6. Leica LMD 7000 Laser Capture Microdissection Microscope
    Siegfried Janz; Fiscal Year: 2013
    ..in a newly developed pig model of human cystic fibrosis;Maureen Donovan studies transporter proteins in the nasal mucosa for improved drug delivery systems to the brain;and David Soll evaluates factors of pathogenicity in the yeast, ..
  7. Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal Pathogenesis
    Rituparna Das; Fiscal Year: 2013
    ..the immune system with the bacterium will allow us to appreciate how pneumococcus exists as a colonizer in the nasal mucosa but causes destructive invasive disease in the lungs...
  8. A NOVEL METHOD TO TREAT CHRONIC PAIN
    SATHYANARAYANA N MURTHY; Fiscal Year: 2013
    ..Following frequent and prolonged administration of the formulation, the nasal mucosa, olfactory mucosa, olfactory bulb, brain and spinal cord will be isolated and subjected to histological ..
  9. Lipid Effector Molecules of Innate Immunity: Antimicrobial Cholesteryl Esters
    Edith Porter; Fiscal Year: 2013
    ..We will validate our results with primary epithelial cells established from sino-nasal mucosa obtained as surgical excess material, and confirm key regulators with siRNA methodology...
  10. WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in AD
    Neelima B Chauhan; Fiscal Year: 2012
    ..by virtue of its endocytic uptake preference, but will also facilitate passive diffusion of 3A1 due to its nasal mucosa-like biochemical composition, maximizing immunotherapeutic efficacy of intranasal passive immunization, to be ..
  11. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2009
    ..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa. An advantage of this route is that it should deliver virus to the entire trigeminal nerve, including the ..
  12. The Cardiopulmonary Effects of Particulate Exposure
    David C Christiani; Fiscal Year: 2013
    ..arterial stiffness;and 3) epigenetic changes, measured by global methylation in DNA from peripheral blood and nasal mucosa brushings of exposed individuals...
  13. Nasal solitary chemosensory cells linking irritation to inflammation
    Marco Tizzano; Fiscal Year: 2013
    ..b>Nasal mucosa irritation also activates inflammatory and local immune responses aimed to protect the nasal epithelium and ..
  14. Prevention of Allergic Rhinitis with Topical Immunomodulating Antibodies
    Randall M Goldblum; Fiscal Year: 2011
    ..can provide an effective "barrier" between an inhaled allergen and patient's IgE antibodies in the nasal mucosa. Further, these results will lay the ground work for Phase II studies, in which we will;a) produce and test ..
  15. Mechanisms of prion transport
    Richard A Bessen; Fiscal Year: 2013
    ..the pathway of prion movement in neurons, studies will investigate the spread of prions between the brain and nasal mucosa within olfactory receptor neurons...
  16. Civamide Nasal Spray for the Treatment of Postherpetic Neuralgia of the Trigemina
    Scott B Phillips; Fiscal Year: 2013
    ..3,4,5 The [TN] also has superficial nerve endings in the nasal mucosa, which are the targets of Civamide Nasal Spray...
  17. R01-Williajm - Double-Blind Placebo-Controlled trial of Nicotine Nasal Spray as a
    Jill M Williams; Fiscal Year: 2010
    ..Nicotine Nasal Spray (NNS) differs from other forms of NRT in that nicotine is absorbed rapidly through the nasal mucosa and produces physiological effects that are expected to speed relief of withdrawal and craving...
  18. Vaginal Immunity After Intranasal Listeria Vaccination
    Fred Frankel; Fiscal Year: 2009
    ..Our own preliminary studies confirm this, and show that the nasal mucosa is even more sensitive than the gut to infection and translocation by Lm...
  19. PYRIDINE--ENZYME INDUCTION, METABOLISM, AND TOXICITY
    Melissa Runge Morris; Fiscal Year: 1991
    ..provide important information on the induction of cytochrome P-450 in extrahepatic tissues, particularly the nasal mucosa and lung, and the effects of induction on xenobiotic metabolism and toxicity in these tissues...
  20. INTERPLAY OF ALLERGIC RHINITIS AND NASAL HUMIDIFICATION
    Robert Naclerio; Fiscal Year: 1999
    ..chamber to test the hypotheses that: a) the induction of allergic inflammation reduces the ability of the nasal mucosa to warm and humidify CDA; b) the nasal response to CDA of individuals with perennial allergic rhinitis exceeds ..
  21. TOXIC RESPONSES OF NASAL MUCOSA TO INHALED IRRITANTS
    John Morris; Fiscal Year: 2000
    ..Substance P exerts a variety of effects in human and rodent nasal mucosa including vasodilation and increased blood flow, increased vascular permeability leading to edemagenesis, and ..
  22. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 2000
    ..Adhesion to the nasal mucosa increases the transit time of the microparticles and facilitates absorption of these GTF-containing ..
  23. Nasal Contour Pack for Epistaxis
    PAUL BUREK; Fiscal Year: 2002
    ..Desiccated sponges are solid and immalleable during insertion, often damaging the nasal mucosa. RBDC proposes to develop and test the Nasal Contour Pack (C-Pack)...
  24. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..NNK is a potent pulmonary carcinogen in rodents and also induces tumors of the pancreas, nasal mucosa, and liver...
  25. Nasal Contour Pack for Epistaxis
    KENNETH WEIL; Fiscal Year: 2004
    ..Desiccated sponges are solid and immalleable during insertion, often damaging the nasal mucosa. RBDC developed and tested the Pillow Pac on an anatomical model in Phase I...
  26. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004
    ..hypothesis that chlipoplexes will deliver effectively the pDNAs without any significant adverse effects in the nasal mucosa and provide significant protection against viral infections...
  27. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ..tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
  28. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2003
    ..Rat nasal mucosa shows high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid ..
  29. Proteomics of Staphylococcus aureus nasal carriage
    Alexander Cole; Fiscal Year: 2003
    The human nasal mucosa is an accessible and clinically important model for the study of microbial interactions with host defenses...
  30. PREVENTION OF NASAL CAVITY TUMORS BY CASTRATION
    PARVIZ POUR; Fiscal Year: 1990
    ..activities of P-450 isozymes, particularly those with sex hormone-dependent functions, will be investigated in nasal mucosa and livers of these rats...
  31. EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGEN
    Robert Naclerio; Fiscal Year: 1990
    ..the nasal secretions for the presence of inflammatory mediators and cells before and after exposing the nasal mucosa of volunteers to pollen antigens, this proposal plans to improve the human model of allergic rhinitis in order ..
  32. EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGEN
    Robert Naclerio; Fiscal Year: 1993
    ..the nasal secretions for the presence of inflammatory mediators and cells before and after exposing the nasal mucosa of volunteers to pollen antigens, this proposal plans to improve the human model of allergic rhinitis in order ..
  33. ROLE OF HUMAN NASAL MUCOSAL P450 IN HEAD AND NECK CANCER
    Xinxin Ding; Fiscal Year: 2001
    ..To identify and characterize P450 gene expression in adult and fetal human nasal mucosa. The cellular distribution and developmental expression of various P450 isoforms known to be active in the ..
  34. NITROSAMINE ACTIVATION AND EXTRAHEPATIC P450S
    Sharon Murphy; Fiscal Year: 1999
    ..Preliminary studies with human P450s, rat nasal mucosa and rat esophageal microsomes, indicate that P450 2A enzymes play an important role in the activation of ..
  35. DEVELOPMENT OF TRANSNASAL KETAMINE FOR BREAKTHROUGH PAIN
    FRED MERMELESTEIN; Fiscal Year: 2000
    ..does not induce changes in blood pressure or heart rate and does not demonstrate evidence of toxicity to the nasal mucosa following repetitive administration...
  36. NERVES & NEUROTROPHINS IN ALLERGIC AIRWAY DISEASE
    Alvin Sanico; Fiscal Year: 2004
    ..in AR patients compared to healthy individuals, suggesting perturbations in the neural components of the nasal mucosa. The principal objective of this proposal is to begin to discern the interrelation between the immune and ..
  37. Nasal carriage of S. aureus: host-pathogen interactions
    Alexander M Cole; Fiscal Year: 2010
    ..We hypothesize that 1) the expression of lipocalin-1 is dysregulated in the nasal mucosa of SA carriers, contributing to the progressive colonization of SA, 2) correcting the lipocalin-1 deficiency ..
  38. NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS
    Tomas Ganz; Fiscal Year: 2001
    ..the search for the underlying defect in mucosal immunity: (1) identify the specific topographic areas of the nasal mucosa in which S. aureus is carried; (2) characterize the differences in mucus composition, anti-S...
  39. ESTROGEN REGULATION IN CHOLINERGIC SYSTEMS
    Farida Sohrabji; Fiscal Year: 2001
    ..Due to its proximity and connections with the nasal mucosa, bulb neurons are especially vulnerable to environmental toxins and viruses, as are its efferent fibers that ..
  40. SCOR: CHRONIC DISEASES OF THE AIRWAYS
    Solbert Permutt; Fiscal Year: 1991
    ..Project I, The Response of the Nasal Mucosa to Hyperventilation with Cold, Dry Air, uses the human nose as a possible model of what is going on in the ..
  41. Immunopathology of the Nasal Mucosa in Sarcoidosis
    Jeffrey Berman; Fiscal Year: 2005
    ..Furthermore this work should provide the basis for additional studies pertaining to sarcoidosis. (End of Abstract) ..
  42. ANTI-ID AB VACCINE FOR HUMAN RESPIRATORY SYNCYTIAL VIRUS
    JOHN SLACK; Fiscal Year: 1992
    ..anti-Id) vaccination, on the other hand, seems ideally suited to generate passive immunity in the nasal mucosa of at risk infants...
  43. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  44. Temporal Integration in Nasal Lateralization
    Paul Wise; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  46. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  47. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  48. Cytokines on Olfactory Receptor Neuron Function
    Andrew Lane; Fiscal Year: 2006
    ..Additional bench research will be performed in the laboratory of Dr. Schleimer, an established scientist with expertise in airway inflammation and cytokine modulation of cell function. ..
  49. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
  50. Mechanisms of prion transport
    RICHARD BESSEN; Fiscal Year: 2008
    ..the pathway of prion movement in neurons, studies will investigate the spread of prions between the brain and nasal mucosa within olfactory receptor neurons...
  51. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  52. THE CPA: SOMATIC AND AUTONOMIC SYSTEMS
    W Panneton; Fiscal Year: 2004
    ..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
  53. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..The seminal findings which have emanated from this grant effort since 1982 will again remain focused on the cellular and molecular events required for induction of mucosal immunity or oral tolerance in the GI tract. ..
  54. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  55. NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGING
    Kohtaro Fujihashi; Fiscal Year: 2010
    ....
  56. Reflexes and Supraesophageal Consequences of Reflux Disease
    Brendan J Canning; Fiscal Year: 2010
    ..This research may also help identify novel therapeutic strategies for treating both GERD and chronic cough. ..
  57. ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2010
    ..4) Determination of the precise mechanism for cross-talk between Ad-FL-induced salivary DCs, B-1 B cells and yS T cells for salivary S-lgA Ab responses. ..
  58. NOX-mediated proton secretion by airways
    Horst Fischer; Fiscal Year: 2006
    ..This will help develop novel therapeutical targets for the treatment of airway acidity and inflammatory airway diseases. ..
  59. Airborne Transmission of Viruses in Human Subjects: Efficacy of Face Masks
    Werner Bischoff; Fiscal Year: 2007
    ..This cnowledge is paramount in view of the inevitable viral pandemics. ..
  60. CONTROL OF EPIDEMIC INFLUENZA
    PEDRO PIEDRA; Fiscal Year: 2007
    ..abstract_text> ..
  61. Regulation of ENaC by Serine Proteases in Airways
    Scott Donaldson; Fiscal Year: 2006
    ..The PI's long term goals are to provide important new insights into the basic elements of airway defense, CF lung disease, and to bring these findings to the development of novel therapies for CF lung disease. ..