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| cochlear nerveSummarySummary: The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing. Top Publications
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Publications
Cortical auditory evoked potentials in the assessment of auditory neuropathy: two case studiesWendy Pearce
National Acoustic Laboratories, Chatswood, New South Wales, Australia
J Am Acad Audiol 18:380-90. 2007..The case studies of two infants are presented that demonstrate how these higher order electrophysiological responses may be utilized in the audiological management of some infants with auditory neuropathy...
Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing lossSharon G Kujawa
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 29:14077-85. 2009..sensory cells intact, but cause acute loss of afferent nerve terminals and delayed degeneration of the cochlear nerve. Results suggest that noise-induced damage to the ear has progressive consequences that are considerably more ..- Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humansJohn J Guinan
Harvard Medical School, Boston, Massachusetts, USA
Ear Hear 27:589-607. 2006..Monitoring MOC effects in humans using OAEs should continue to provide valuable insights into the role of MOC efferents and may also provide clinical benefits... - Dynamic range adaptation to sound level statistics in the auditory nerveBo Wen
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Neurosci 29:13797-808. 2009..These findings suggest that adaptive processing of sound levels first occurs in the auditory periphery and is enhanced along the auditory pathway... - Correct tonotopic representation is necessary for complex pitch perceptionAndrew J Oxenham
Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 101:1421-5. 2004..The experiments demonstrate that tonotopic representation is crucial to complex pitch perception and provide a new tool in the search for the neural basis of pitch... - Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea functionM Knipper
University of Tubingen, Department of Oto Rhino Laryngology, Tübingen Centre for Hearing Research, Röntgenweg 11, D 72076 Tubingen, Germany
Development 125:3709-18. 1998..The thyroid hormone-dependent commencement of nerve conduction is discussed in connection with the patterning refinement of central auditory pathways and the acquisition of deafness... - Cochlear efferent feedback balances interaural sensitivityKeith N Darrow
Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, Massachusetts 02114, USA
Nat Neurosci 9:1474-6. 2006..Thus, lateral olivocochlear feedback maintains the binaural balance in neural excitability required for accurate localization of sounds in space... - Spontaneous activity of auditory-nerve fibers: insights into stochastic processes at ribbon synapsesPeter Heil
Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
J Neurosci 27:8457-74. 2007..Our findings also constitute an essential step toward a better understanding of the spike-train representation of time-varying stimuli initiated at this synapse, and thus of the fundamentals of temporal coding in the auditory pathway... 
Unique expression of connexins in the human cochleaWei Liu
Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden
Hear Res 250:55-62. 2009..Their potential role in the processing of human auditory nerve signaling as well as non-GJ roles of the connexins in human cochlea is discussed...- Human frequency-following response: representation of pitch contours in Chinese tonesAnanthanarayan Krishnan
Auditory Electrophysiology Laboratory, Department of Audiology and Speech Sciences, Purdue University, West Lafayette, IN 47907 2038, USA
Hear Res 189:1-12. 2004..These FFR findings support the viability of early, population-based 'predominant interval' representations of pitch in the auditory brainstem that are based on temporal patterns of phase-locked neural activity... - Phase-locked responses to tones of chinchilla auditory nerve fibers: implications for apical cochlear mechanicsAndrei N Temchin
Hugh Knowles Center Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
J Assoc Res Otolaryngol 11:297-318. 2010.... - Delivery of neurotrophin-3 to the cochlea using alginate beadsFarnoosh Noushi
University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
Otol Neurotol 26:528-33. 2005..CONCLUSIONS: This study demonstrates alginate beads to be a safe, biodegradable and effective delivery system for NT-3 to the cochlea... - Binaural and cochlear disparitiesPhilip X Joris
Laboratory of Auditory Neurophysiology, University of Leuven, Campus Gasthuisberg, B 3000 Leuven, Belgium
Proc Natl Acad Sci U S A 103:12917-22. 2006..These findings suggest that cochlear disparities make an important contribution to the internal delays observed in binaural neurons... - Panoramic measurements of the apex of the cochleaMarcel van der Heijden
Laboratory of Auditory Neurophysiology, K U Leuven Medical School, B 3000 Leuven, Belgium
J Neurosci 26:11462-73. 2006.... - Temporal processing from the auditory nerve to the medial nucleus of the trapezoid body in the ratA G Paolini
Department of Otolarynology, The University of Melbourne, Royal Victoria Eye and Ear Hospital, East Melbourne, Australia
Hear Res 159:101-16. 2001..Our results suggest that AVCN PL(N) units, representing globular bushy cells, are specialised for enhancing the temporal code at low frequencies and relaying this information to principal cells of the MNTB... - Firing patterns of type II spiral ganglion neurons in vitroMichael A Reid
Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08854-8082, USA
J Neurosci 24:733-42. 2004..In particular, the type II neuron properties are consistent with cells in other sensory systems that receive convergent synaptic input for high-sensitivity stimulus detection... - Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neuronsJENNIFER A CHIKAR
Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109 5616, United States
Hear Res 245:24-34. 2008..These results indicate that the changes in the anatomy of the auditory nerve induced by the combination of Ad.BDNF inoculation and the electrical stimulation used for testing improved functional measures of CI performance... - Human frequency-following responses: representation of steady-state synthetic vowelsAnanthanarayan Krishnan
Auditory Electrophysiology Laboratory, Department of Audiology and Speech Sciences, Purdue University, W Lafayette, IN 47907, USA
Hear Res 166:192-201. 2002.... - Imaging findings of cochlear nerve deficiencyChristine M Glastonbury
Department of Radiology, University Hospital, Salt Lake City, UT, USA
AJNR Am J Neuroradiol 23:635-43. 2002..Absence or reduction in caliber of the cochlear nerve (deficiency) has been described in association with congenital sensorineural hearing loss (SNHL)... - Aplasia of the cochlear nerve: a temporal bone studyE G Nelson
Section of Otolaryngology-Head and Neck Surgery, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 1035, Chicago, IL 60637, USA
Otol Neurotol 22:790-5. 2001OBJECTIVE: The purpose of this study was to evaluate the temporal bone findings in individuals with cochlear nerve aplasia. STUDY DESIGN: Retrospective case review... - A phenomenological model of peripheral and central neural responses to amplitude-modulated tonesPaul C Nelson
Department of Bioengineering and Neuroscience and Institute for Sensory Research, Syracuse University, Syracuse, New York 13244, USA
J Acoust Soc Am 116:2173-86. 2004.... - Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humansFred H Linthicum
House Ear Institute, Los Angeles, California, USA
Otol Neurotol 30:418-422. 2009..To demonstrate that contrary to what occurs in animals, neuron loss in the human spiral ganglion is not in proportion to organ of Corti hair or supporting cell loss... - Disruption of lateral efferent pathways: functional changes in auditory evoked responsesColleen G Le Prell
Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109 0506, USA
J Assoc Res Otolaryngol 4:276-90. 2003..They also confirm the suggestion that changes in single-unit auditory nerve activity after cutting the olivocochlear bundle are probably a consequence of disrupting the more lateral of the two olivocochlear efferent pathways... - Neural encoding in the human brainstem relevant to the pitch of complex tonesAnanthanarayan Krishnan
Department of Speech Language Hearing Sciences, Purdue University, 1353 Heavilon Hall, 500 Oval Drive, West Lafayette, IN 47907 2038, USA
Hear Res 275:110-9. 2011..The scalp recorded FFR may provide for a non-invasive analytic tool to evaluate neural encoding of complex sounds in humans... - Response characteristics in the apex of the gerbil cochlea studied through auditory nerve recordingsCorstiaen P C Versteegh
Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
J Assoc Res Otolaryngol 12:301-16. 2011..Overall, our data suggest that mechanical responses in the apex of the cochlea are considerably nonlinear and that these nonlinearities are of a different character than those known from the base of the cochlea... - The clinical application of potentials evoked from the peripheral auditory systemCharles A Miller
Department of Otolaryngology, University of Iowa, United States
Hear Res 242:184-97. 2008..Future research directions, which will likely involve the integration of various dimensions of the electrically evoked response that have been studied in isolation, are also suggested... - Chronic reduction of endocochlear potential reduces auditory nerve activity: further confirmation of an animal model of metabolic presbyacusisHainan Lang
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Charleston, SC 29425, USA
J Assoc Res Otolaryngol 11:419-34. 2010..These results suggest that dysfunction of the cochlear lateral wall and subsequent chronic reduction in the EP can directly affect the activity patterns of primary auditory neurons in a manner similar to that seen in aged gerbils... - Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing lossHainan Lang
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 26:3541-50. 2006..A possible mechanism underlying this protection is that the NFkappaB activity may help to maintain calcium homeostasis in SGNs... - Internal auditory canal morphology in children with cochlear nerve deficiencyOliver F Adunka
Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7600, USA
Otol Neurotol 27:793-801. 2006..To describe the internal auditory canal (IAC) and inner ear morphologic characteristics of children with cochlear nerve (CN) deficiency. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center... - Physiological effects of auditory nerve myelinopathy in chinchillasMohamed M El Badry
Otolaryngology Department, Audiology Unit, El Minia University Hospitals, El Minia University, El Minia, Egypt
Eur J Neurosci 25:1437-46. 2007..The results support auditory nerve myelinopathy as a possible pathomechanism of auditory neuropathy but indicate that myelinopathy must be severe before physiological measures are affected... - Site of cochlear stimulation and its effect on electrically evoked compound action potentials using the MED-EL standard electrode arrayStefan Brill
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Wurzburg, Germany
Biomed Eng Online 8:40. 2009..The aim of this study is to determine if certain properties of ECAP recordings vary, depending on the stimulation site in the cochlea... - Are cochlear implant patients suffering from perceptual dissonance?Gerald E Loeb
Department of Biomedical Engineering, Viterbi School of Engineering and A E Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles 90089 1112, USA
Ear Hear 26:435-50. 2005.... - Auditory neuropathy characteristics in children with cochlear nerve deficiencyCraig A Buchman
Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Ear Hear 27:399-408. 2006To describe a group of children exhibiting electrophysiologic responses characteristic of auditory neuropathy (AN) who were subsequently identified as having absent or small cochlear nerves (i.e., cochlear nerve deficiency). - The volley theory and the spherical cell puzzleP X Joris
Laboratory of Auditory Neurophysiology, K U Leuven, Campus GHB O and N2, Herestraat 49 bus 1021, B 3000 Leuven, Belgium
Neuroscience 154:65-76. 2008.... - In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem responseSanjiv B Amin
Department of Pediatrics, Division of Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
J Pediatr 156:377-81. 2010..To determine whether cord ferritin (CF) concentration, an index of in utero iron status, is associated with auditory neural maturation in premature infants... - Threshold tuning curves of chinchilla auditory nerve fibers. II. Dependence on spontaneous activity and relation to cochlear nonlinearityAndrei N Temchin
Dept of Communication Sciences and Disorders, Northwestern Univ, 2240 Campus Dr, Evanston, IL 60208 3550, USA
J Neurophysiol 100:2899-906. 2008..It is shown here that this dependence of tuning on spontaneous rates is consistent with a previously unnoticed nonmonotonic dependence on iso-velocity criterion of the frequency tuning of basilar membrane vibrations... - Threshold tuning curves of chinchilla auditory-nerve fibers. I. Dependence on characteristic frequency and relation to the magnitudes of cochlear vibrationsAndrei N Temchin
Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
J Neurophysiol 100:2889-98. 2008..At the apex of the chinchilla cochlea, frequency tuning is substantially sharper for ANFs than for available recordings of organ of Corti vibrations... - Comparison of bandwidths in the inferior colliculus and the auditory nerve. II: Measurement using a temporally manipulated stimulusMyles Mc Laughlin
Laboratory of Auditory Neurophysiology, Medical School, K U Leuven, Campus Gasthuisberg O and N 2, Herestraat 49 bus 1021, B 3000 Leuven, Belgium
J Neurophysiol 100:2312-27. 2008..We conclude that binaural sensitivity is more dependent on correlation sensitivity than has hitherto been appreciated and that the mechanisms underlying correlation sensitivity should be addressed in future studies... - Functional anatomy of the human cochlear nerve and its role in microvascular decompressions for tinnitusDirk De Ridder
Department of Neurosurgery and Otorhinolaryngology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium
Neurosurgery 54:381-8; discussion 388-90. 2004The functional anatomy (i.e., tonotopy) of the human cochlear nerve is unknown... - Comparison of bandwidths in the inferior colliculus and the auditory nerve. I. Measurement using a spectrally manipulated stimulusMyles Mc Laughlin
Laboratory of Auditory Neurophysiology, Medical School, Campus Gasthuisberg, Leuven, Belgium
J Neurophysiol 98:2566-79. 2007..We find that both AN and IC filter BW depend on characteristic frequency, but that there is no difference in mean BW between the AN and IC... - Variation in the phase of response to low-frequency pure tones in the guinea pig auditory nerve as functions of stimulus level and frequencyAlan R Palmer
MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
J Assoc Res Otolaryngol 10:233-50. 2009..This null frequency was often not at the CF. At stimulation frequencies below the null, there was a progressive lag with sound level and a progressive lead for stimulation frequencies above the null. This was maximally 0.2 cycles... - Apparent cochlear nerve aplasia: to implant or not to implant?Frank M Warren
Division of Otolaryngology, Head and Neck Surgery, University of Utah, Salt Lake City, Utah 84132, U S A
Otol Neurotol 31:1088-94. 2010To describe the imaging findings and clinical outcomes of children with apparent cochlear nerve aplasia undergoing cochlear implantation. - Microvascular decompression of cochlear nerve for tinnitus incapacity: pre-surgical data, surgical analyses and long-term follow-up of 15 patientsNicolas Guevara
Department of Otorhinolaryngology, CHU de Nice, Hopital Pasteur, 30, avenue de la Voie Romaine, B P 69, 06002 Nice, Cedex 1, France
Eur Arch Otorhinolaryngol 265:397-401. 2008..However, cochlear nerve compression syndrome by vascular loop is still a controversial topic... - Functional correlates of characteristic frequency in single cochlear nerve fibers of the Mongolian gerbilK K Ohlemiller
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208
J Comp Physiol A 167:329-38. 1990..thresholds encountered, even when data from many animals were combined, rarely exceeded 20 dB, suggesting that cochlear nerve responses obtained from this species display little inter-animal variability... - Preliminary results of auditory brainstem implantation in prelingually deaf children with inner ear malformations including severe stenosis of the cochlear aperture and aplasia of the cochlear nerveLevent Sennaroglu
Department of Otolaryngology, Hacettepe University Medical Faculty, Ankara, Turkey
Otol Neurotol 30:708-15. 2009..The aim of our study is to present the results of 11 children where auditory brainstem implantation (ABI) was successfully performed to restore hearing... - Brainstem auditory-evoked potentials in iron-deficiency anemiaS U Sarici
Department of Pediatrics, , Ankara, Turkey
Pediatr Neurol 24:205-8. 2001..Although we could not demonstrate a hearing loss in infants with moderate iron-deficiency anemia in this study, the relationship between severe iron-deficiency anemia and hearing loss or auditory dysfunction remains to be determined... - Interaural time sensitivity dominated by cochlea-induced envelope patternsPhilip X Joris
Laboratory of Auditory Neurophysiology, Medical School, Campus Gasthuisberg, K U Leuven, B 3000 Leuven, Belgium
J Neurosci 23:6345-50. 2003..These results suggest that internally generated envelopes play a more important role in binaural hearing than is commonly thought... - Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochleaWaheeda A Hossain
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 25:6857-68. 2005..6 and Nav1.2 in the cochlear ganglion, cochlear nerve, and organ of Corti, including the type I and type II ganglion cells. In most type I ganglion cells, Nav1... - Temporal properties of responses to broadband noise in the auditory nerveDries H G Louage
Laboratory of Auditory Neurophysiology, Medical School, K.U.Leuven, B-3000 Leuven, Belgium
J Neurophysiol 91:2051-65. 2004..We conclude that the combined use of broadband noise and SAC analysis allow a more general characterization of temporal behavior than periodic stimuli and Fourier analysis... - Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapseLisa Grant
The Johns Hopkins School of Medicine, Department of Otolaryngology Head and Neck Surgery, Baltimore, Maryland 21205, USA
J Neurosci 30:4210-20. 2010..We propose that the relative contribution of two modes of multivesicular release, generating monophasic and multiphasic EPSCs, may underlie fundamental characteristics of auditory nerve fibers... - Subthreshold K+ channel dynamics interact with stimulus spectrum to influence temporal coding in an auditory brain stem modelMitchell L Day
Center for Neural Science, New York University, New York, NY, USA
J Neurophysiol 99:534-44. 2008.... - A model of the electrically excited human cochlear neuron. I. Contribution of neural substructures to the generation and propagation of spikesF Rattay
TU BioMed, Vienna University of Technology, Austria
Hear Res 153:43-63. 2001..Comparing the reactions of a human and cat cochlear neuron, we find differences in spiking behavior, e.g. peripherally and centrally evoked spikes arrive with a time difference of about 400 mus in man and 200 mus in cat... - Effect of deep insertion of the cochlear implant electrode array on pitch estimation and speech perceptionJafar Hamzavi
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria
Acta Otolaryngol 126:1182-7. 2006..Deeply inserted electrodes offer the possibility that apical stimulation may improve speech performances. Therefore, deep insertion is reasonable and should be performed in patients with profound or total hearing loss... - Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerveStephane F Maison
Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Neurophysiol 90:2941-9. 2003..This constitutes the most direct evidence to date for a functional role of the lateral OC system in the auditory periphery... - Tuning and timing in the gerbil ear: Wiener-kernel analysisEdwin R Lewis
Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA
Hear Res 174:206-21. 2002..Eigen or singular-value decomposition of the second-order Wiener kernel allows us to separate excitatory and suppressive effects, and to determine precisely the timing of the latter... - C-Fos immunoreactivity mapping of the auditory system after electrical stimulation of the cochlear nerve in ratsMakoto Nakamura
Department of Neurosurgery, Nordstadt Hospital, Haltenhoffstr 41, 30167 Hannover, Germany
Hear Res 184:75-81. 2003..as a marker for functional mapping in the auditory system in response to direct electrical stimulation of the cochlear nerve in the cerebellopontine angle... - A nonlinear filter-bank model of the guinea-pig cochlear nerve: rate responsesChristian J Sumner
Centre for the Neural Basis of Hearing at Essex, Department of Psychology, University of Essex, Colchester CO4 3SQ, United Kingdom
J Acoust Soc Am 113:3264-74. 2003..The model is a convenient computational tool for the simulation of the range of nonlinear tuning and rate-responses found across the length of the guinea-pig cochlear nerve. - Effect of interphase gap and pulse duration on electrically evoked potentials is correlated with auditory nerve survivalPavel Prado-Guitierrez
Department of Otolaryngology, The University of Melbourne, Australia
Hear Res 215:47-55. 2006..These results may provide a tool for investigating the contribution of auditory nerve survival to clinical performance among cochlear implant subjects... - A phenomenological model for the responses of auditory-nerve fibers. II. Nonlinear tuning with a frequency glideQing Tan
Boston University Hearing Research Center, Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
J Acoust Soc Am 114:2007-20. 2003..The ability of this model to process arbitrary sound inputs makes it a useful tool for studying peripheral auditory processing... - Mathematical models of cochlear nucleus onset neurons: I. Point neuron with many weak synaptic inputsSridhar Kalluri
Harvard University Massachusetts Institute of Technology, Division of Health Sciences and Technology, Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Comput Neurosci 14:71-90. 2003..These results show a tradeoff, that may be a general property of many neurons, between following rapid stimulus fluctuations and responding without short interspike intervals at the onset of sustained stimuli... - Adaptation in a revised inner-hair cell modelChristian J Sumner
Centre for the Neural Basis of Hearing at Essex, Department of Psychology, University of Essex, Colchester CO4 3SQ, United Kingdom
J Acoust Soc Am 113:893-901. 2003..A HSR model fiber performs similarly to the earlier version of the model. However, there is considerable variation in response to increments and decrements between different model fibers... - Mathematical models of cochlear nucleus onset neurons: II. model with dynamic spike-blocking stateSridhar Kalluri
Harvard University Massachusetts Institute of Technology, Division of Health Sciences and Technology, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Comput Neurosci 14:91-110. 2003..These results provide a mechanistic rationale for distinguishing between the different physiological classes of CN On neurons... - Time course and calcium dependence of transmitter release at a single ribbon synapseJuan D Goutman
Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 824, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:16341-6. 2007..By varying Ca(2+) buffering in the IHC, we further investigate how Ca(2+) channel and Ca(2+) sensor at this synapse might relate... - 3-T imaging of the cochlear nerve and labyrinth in cochlear-implant candidates: 3D fast recovery fast spin-echo versus 3D constructive interference in the steady state techniquesJohn I Lane
Department of Radiology, Mayo Clinic, Rochester, MN, USA
AJNR Am J Neuroradiol 25:618-22. 2004..0 T. We predict that the superior CNRs obtained with 3D CISS will prove advantageous as we move to smaller fields of view at higher field strength... - Ensemble spontaneous activity in the guinea-pig cochlear nerveG D Searchfield
Discipline of Audiology and Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, New Zealand
Hear Res 192:23-35. 2004..from the round window (RW) of the cochlea is referred to as the ensemble spontaneous activity (ESA) of the cochlear nerve. The ESA is considered to represent the summed spontaneous activity of single fibers of the auditory nerve and .. - The temporal representation of speech in a nonlinear model of the guinea pig cochleaStephen D Holmes
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Acoust Soc Am 116:3534-45. 2004.... - Electrical stimulation of the cochlear nerve in rats: analysis of c-Fos expression in auditory brainstem nucleiMakoto Nakamura
Department of Neurosurgery, Klinikum Hannover Nordstadt, Hannover, Germany
Brain Res 1031:39-55. 2005..functional activation of central auditory brainstem nuclei in response to direct electrical stimulation of the cochlear nerve using c-Fos immunoreactivity as a marker for functional mapping... - Response properties of the refractory auditory nerve fiberC A Miller
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City 52242, USA
J Assoc Res Otolaryngol 2:216-32. 2001..Relative spread was found to increase with decreasing MPI values, providing direct evidence that stochastic properties of fibers are altered under conditions of refractoriness... - Rate and timing cues associated with the cochlear amplifier: level discrimination based on monaural cross-frequency coincidence detectionM G Heinz
Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
J Acoust Soc Am 110:2065-84. 2001..quot; Monaural coincidence detection is a physiologically realistic mechanism that is extremely general in that it can utilize AN information (average-rate, synchrony, and nonlinear-phase cues) from all SR groups... - A model of the electrically excited human cochlear neuron. II. Influence of the three-dimensional cochlear structure on neural excitabilityF Rattay
TU BioMed, Vienna University of Technology, Austria
Hear Res 153:64-79. 2001..2001] allows for simulation of the excitation process of selected elements of the cochlear nerve. The bony boundary has an insulating influence along every nerve fiber which shifts the stimulation condition .. - Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibersStephane F Maison
Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 3096, USA
J Assoc Res Otolaryngol 10:50-63. 2009..Our results suggest that GABAergic signaling in type II afferent neurons may be required for normal outer hair cell amplifier function at low sound levels and may also modulate outer hair cell responses to high-level sound... - Intracochlear and extracochlear ECAPs suggest antidromic action potentialsCharles A Miller
Department of Otolaryngology, Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21201 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA
Hear Res 198:75-86. 2004..Compared with the feline ECAPs, the human potentials had smaller amplitudes and longer latencies. It is not clear what underlies these differences, although several factors are considered... - A model of a nucleus 24 cochlear implant fitting protocol based on the electrically evoked whole nerve action potentialKevin H Franck
Center for Childhood Communication, Children's Hospital of Philadelphia, Pennsylvania 19104, USA
Ear Hear 23:67S-71S. 2002..The realization of this model would only require two loudness judgments from the patient, whereas traditional fitting requires 44, and would be fit in a live-voice mode, accounting for across-electrode loudness summation... - Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of CortiC Eduardo Corrales
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
J Neurobiol 66:1489-500. 2006..degeneration, we injected EYFP-expressing embryonic stem cell-derived mouse neural progenitor cells into the cochlear nerve trunk in immunosuppressed animals 1 week after destroying the cochlear nerve (spiral ganglion) cells while .. - Measuring the refractoriness of the electrically stimulated auditory nerveAndre Morsnowski
Cochlear Implant Centrum Schleswig Kiel, Department of Oto Rhino Laryngology, Head and Neck Surgery, Christian Albrechts University of Kiel, Kiel, Germany
Audiol Neurootol 11:389-402. 2006..This can bias the measurement of ECAP thresholds. Additionally, the shape of standard forward masking recovery functions was explained by the influence of latency shift of the neural response... - Delayed neurotrophic treatment preserves nerve survival and electrophysiological responsiveness in neomycin-deafened guinea pigsTakahiko Yamagata
Center for Hearing and Communication Research and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Neurosci Res 78:75-86. 2004..It is noteworthy that this same degree of ganglion cell loss, secondary to receptor damage, is typically observed after a period equivalent to some years of deafness in humans... - A revised model of the inner-hair cell and auditory-nerve complexChristian J Sumner
Centre for the Neural Basis of Hearing at Essex, Department of Psychology, University of Essex, Colchester, United Kingdom
J Acoust Soc Am 111:2178-88. 2002..The model also reproduces quantitatively phase-locking characteristics, relative refractory effects, mean-to-variance ratio, and first- and second-order discharge history effects... - A simple two-component model of the electrically evoked compound action potential in the human cochleaW K Lai
ENT Department, University Hospital, Zurich, Switzerland
Audiol Neurootol 5:333-45. 2000..This information could be useful for determining optimal speech coding parameters for cochlear implant users on an individual basis... - Contributions of ion conductances to the onset responses of octopus cells in the ventral cochlear nucleus: simulation resultsY Cai
Developmental Auditory Physiology Laboratory, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
J Neurophysiol 83:301-14. 2000..On the other hand, I(h), which is activated during hyperpolarization, does not play a large role in the basic onset response pattern but may regulate response threshold through its contribution to the membrane conductance... - Wiener-kernel analysis of responses to noise of chinchilla auditory-nerve fibersAlberto Recio-Spinoso
Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208-3550, USA
J Neurophysiol 93:3615-34. 2005..Thus onset delays, frequency glides, and near-CF group delays could be estimated for auditory-nerve fibers innervating the entire length of the chinchilla cochlea... - Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigsLisa N Gillespie
Department of Otolaryngology, The University of Melbourne, 2nd Floor, Eye and Ear Hospital, East Melbourne, Victoria, Australia 3002
Neuroreport 15:1121-5. 2004..Although delayed, the treatment with each neurotrophin prevented further degeneration with similar efficacy... - Cochlear nerve demyelination causes prolongation of wave I latency in ABR of the myelin deficient (md) ratTetsufumi Ito
Department of Anatomy, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Hear Res 191:119-24. 2004..ABRs showed a marked prolongation not only wave II-IV latencies but also wave I latency. Cochlear nerve fibers near the modiolus lost their myelin halfway into the internal auditory canal... - Hearing habilitation with auditory brainstem implantation in two children with cochlear nerve aplasiaV Colletti
ENT Department, Clinica ORL, University of Verona, Ospedale Policlinico G B Rossi, Piazzale L A Scuro, 10, I 37134 Verona, Italy
Int J Pediatr Otorhinolaryngol 60:99-111. 2001Patients with aplasia and hypoplasia of the cochlear nerve have no chance of having their hearing restored by stimulating the periphery of the auditory system using the traditional cochlear implant... - Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleusMikiya Asako
Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0506, USA
J Neurosci Res 81:102-9. 2005..These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine... - An introduction to the biophysics of the electrically evoked compound action potentialJay T Rubinstein
Department of Otolaryngology and Bioengineering, The University of Iowa, Iowa City, IA, USA
Int J Audiol 43:S3-9. 2004..Potential applications of this technology in the investigation of the biophysical mechanisms of the implanted cochlea are suggested... - Dopamine inhibition of auditory nerve activity in the adult mammalian cochleaJ Ruel
, Laboratoire de Neurobiologie de l'Audition, 71 rue de Navacelles, 34090 Montpellier, France
Eur J Neurosci 14:977-86. 2001..Results suggest that dopamine may exert a tonic inhibition of the auditory nerve activity. Removal of this tonic inhibition results in the development of early signs of excitotoxicity... - Toward a battery of behavioral and objective measures to achieve optimal cochlear implant stimulation levels in childrenKaren A Gordon
Cochlear Implant Program, Department of Otolaryngology, The Hospital for Sick Children and the University of Toronto, Room 6D08, Toronto, ON, Canada M5G 1X8
Ear Hear 25:447-63. 2004..the first year of implant use? 3) Do ECAP, EABR, and ESR thresholds or behavioral measures change over time? 4) What is the relation between ECAP, EABR, and ESR thresholds and behavioral measures of threshold and comfortably loud levels?.. - Mandarin speech perception in nucleus CI 24 implantees using MAPs based on neural response telemetryYu-Sheng Sun
Department of Speech and Hearing Disorders and Sciences, National Taipei College of Nursing, Taipei, Taiwan
ORL J Otorhinolaryngol Relat Spec 66:255-61. 2004..Therefore, in certain cases that behavioral MAPs are difficult to obtain (such as in very young or multiple handicapped children), NRT-based MAPs may serve reliably as an initial estimation... - Long-term sensorineural hearing loss induces functional changes in the rat auditory nerveRobert K Shepherd
The Bionic Ear Institute, Department of Otolaryngology, The University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
Eur J Neurosci 20:3131-40. 2004..001). These functional changes have implications for recipients of cochlear implants and potential therapies directed toward halting or reversing AN pathology... - Effects of glucocorticoid receptor antagonist on CAPs threshold shift due to short-term sound exposure in guinea pigsTakanori Mori
Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Auris Nasus Larynx 31:395-9. 2004..Seven days after the sound exposure, the compound action potentials (CAPs) of the cochlear nerve and the 2f(1)-f(2) distortion product oto-acoustic emissions (DPOAEs) were recorded... - Downregulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafnessBenjamin Delprat
Institut National de la Santé et de la Recherche Médicale U 254, Laboratoire de Neurobiologie de l audition, 34090 Montpellier, France
J Neurosci 22:1718-25. 2002..Cochlear examination by transmission electron microscopy revealed hair cell loss and degeneration of the organ of Corti. This demonstrates that otospiralin is essential for the survival of the neurosensory epithelium... - [Electrically evoked auditory nerve compound action potentials in Nucleus CI24M cochlear implant users]Xiaoli Zhu
Department of Otorhinolaryngology, Peking Union Medical College Hospital, Beijing 100730
Lin Chuang Er Bi Yan Hou Ke Za Zhi 16:5-8. 2002..CONCLUSION: ECAPs were proved to be useful in adjusting the stimulation parameters of the cochlear implant speech processor in order to maximize an individual's performance with the device, especially in young children... - A model of perceptual segregation based on clustering the time series of the simulated auditory nerve firing probabilityEmili Balaguer-Ballester
Centre for Theoretical and Computational Neuroscience, University of Plymouth, Portland Square, Drake Circus, Plymouth, Devon, UK
Biol Cybern 97:479-91. 2007..The model successfully explains a wide range of perceptual experiments... - Measurement of the electrically evoked compound action potential via a neural response telemetry systemNorbert Dillier
Department of Otorhinolaryngology, University Hospital, , Switzerland
Ann Otol Rhinol Laryngol 111:407-14. 2002..6%) and in 132 of the 160 electrodes (82.5%) tested. In addition to validating this technique, we also established a set of default clinical test parameters... - Diverse responses of single auditory afferent fibres to electrical stimulation of the inferior colliculus in guinea-pigW H A M Mulders
The Auditory Laboratory, Discipline of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, WA 6009, Crawley, Australia
Exp Brain Res 160:235-44. 2005..These data also demonstrate that the olivocochlear system is capable of eliciting highly localized effects on different frequency regions in the cochlea... - Cochlear implantation in an adult patient with auditory neuropathyAkihiro Katada
Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College, Japan
Eur Arch Otorhinolaryngol 262:449-52. 2005..Postoperatively, his audiological performance was significantly improved. We conclude that cochlear implantation can be a valid option for patients with auditory neuropathy... - Predicting dynamic range and intensity discrimination for electrical pulse-train stimuli using a stochastic auditory nerve model: the effects of stimulus noiseYifang Xu
Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708-0291, USA
IEEE Trans Biomed Eng 52:1040-9. 2005..However, since our predictions indicate that intensity discrimination under noise degrades, overall intensity coding performance may not improve significantly... - Neural coding in the chick cochlear nucleusM E Warchol
Auditory Physiology Laboratory, Northwestern University, Evanston, IL 60208
J Comp Physiol A 166:721-34. 1990.... - Neural response to very low-frequency sound in the avian cochlear nucleusM E Warchol
Auditory Physiology Laboratory, Northwestern University, Evanston, IL 60208
J Comp Physiol A 166:83-95. 1989..7. LF units are described whose response to sound is inhibitory at frequencies above 50 Hz... - Multiple auditory steady-state responses in children and adults with normal hearing, sensorineural hearing loss, or auditory neuropathyJoseph Attias
Department of Communication Disorders, Haifa University, Haifa, Israel
Ann Otol Rhinol Laryngol 115:268-76. 2006.... - Speech perception in individuals with auditory neuropathyFan Gang Zeng
University of California, Irvine 92697, USA
J Speech Lang Hear Res 49:367-80. 2006..in participants with auditory neuropathy (AN) was systematically studied to answer the following 2 questions: Does noise present a particular problem for people with AN? Can clear speech and cochlear implants alleviate this problem?..
Research Grants
- High resolution mapping of the Cochlear nerve using optical stimulationJonathon Wells; Fiscal Year: 2007..This research will focus on enhancing the performance of the cochlear implant to allow people to hear speech in a crowded room. ..
- Trophic interactions in developing and adult inner earGabriel Corfas; Fiscal Year: 2006..Phenotypic analysis revealed a hearing disorder associated with post-natal, primary degeneration of cochlear nerve fibers (without hair cell loss) and a balance disorder associated with a reduction in the size of the ..
- HAIR CELL PATHOPHYSIOLOGYJames Saunders; Fiscal Year: 2006..The net effect of these hair cell actions is the production of discharge activity in the cochlear nerve. Tools are now available to dissect the processes in each of these cellular compartments and examine their ..
- NEUROGENESIS IN THE AUDITORY SYSTEMDONALD MOREST; Fiscal Year: 2005Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as major incurable disorders today...
- NEUROTRANSMITTERS IN THE AUDITORY SYSTEMSTEVEN POTASHNER; Fiscal Year: 2004..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
- CELL INTERACTIONS IN THE DEVELOPING AUDITORY SYSTEMThomas Parks; Fiscal Year: 1992..Early destruction of the otocyst (embryonic precursor of the inner ear and cochlear nerve) induces formation of an anomalous functional axonal projection connecting the cochlear nuclei on the two ..
- MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORSAnne Luebke; Fiscal Year: 2009..We determined that the loss of CGRP in knockout mice reduced sound-evoked activity of the cochlear nerve, which would then cause a reduction in the dynamic range of sound perception...
- COCHLEAR NERVE DEVELOPMENTSTEPHEN ECHTELER; Fiscal Year: 2001..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
- ACTIVITY-DEPENDENT DEVELOPMENT OF CALCIUM HOMEOSTASISLance Zirpel; Fiscal Year: 2002..how neurons in the cochlear nucleus respond to the onset and increasing levels of afferent input from the cochlear nerve during development with the implementation of mechanisms to regulate intracellular ion homeostasis...