cochlear nerve

Summary

Summary: The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.

Top Publications

  1. ncbi Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function
    M Knipper
    University of Tubingen, Department of Oto Rhino Laryngology, Tübingen Centre for Hearing Research, Röntgenweg 11, D 72076 Tubingen, Germany
    Development 125:3709-18. 1998
  2. pmc Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss
    Sharon G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:14077-85. 2009
  3. pmc Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
    Wei Chen
    Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
    Nature 490:278-82. 2012
  4. pmc Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss
    Hainan Lang
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3541-50. 2006
  5. pmc Dynamic range adaptation to sound level statistics in the auditory nerve
    Bo Wen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Neurosci 29:13797-808. 2009
  6. pmc Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons
    JENNIFER A CHIKAR
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109 5616, United States
    Hear Res 245:24-34. 2008
  7. ncbi Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans
    John J Guinan
    Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 27:589-607. 2006
  8. pmc A phenomenological model of the synapse between the inner hair cell and auditory nerve: long-term adaptation with power-law dynamics
    Muhammad S A Zilany
    Department of Biomedical Engineering, University of Rochester, NY 14642, USA
    J Acoust Soc Am 126:2390-412. 2009
  9. ncbi Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve
    Zhengqing Hu
    Center for Hearing and Communication Research, and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1026:68-73. 2004
  10. ncbi Auditory neuropathy characteristics in children with cochlear nerve deficiency
    Craig A Buchman
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ear Hear 27:399-408. 2006

Research Grants

  1. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2006
  2. NEUROGENESIS IN THE AUDITORY SYSTEM
    DONALD MOREST; Fiscal Year: 2005
  3. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2004
  4. ACTIVITY-DEPENDENT DEVELOPMENT OF CALCIUM HOMEOSTASIS
    Lance Zirpel; Fiscal Year: 2002
  5. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 2001
  6. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
  7. OBJECTIVE MEASURE OF LOW-FREQUENCY INNER EAR FUNCTION
    JEFFERY LICHTENHAN; Fiscal Year: 2013
  8. 2013 and 2015 Conferences on Implantable Auditory Prostheses
    Robert V Shannon; Fiscal Year: 2013
  9. High resolution mapping of the Cochlear nerve using optical stimulation
    Jonathon Wells; Fiscal Year: 2009
  10. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 2000

Detail Information

Publications297 found, 100 shown here

  1. ncbi Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function
    M Knipper
    University of Tubingen, Department of Oto Rhino Laryngology, Tübingen Centre for Hearing Research, Röntgenweg 11, D 72076 Tubingen, Germany
    Development 125:3709-18. 1998
    ..The thyroid hormone-dependent commencement of nerve conduction is discussed in connection with the patterning refinement of central auditory pathways and the acquisition of deafness...
  2. pmc Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss
    Sharon G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:14077-85. 2009
    ..sensory cells intact, but cause acute loss of afferent nerve terminals and delayed degeneration of the cochlear nerve. Results suggest that noise-induced damage to the ear has progressive consequences that are considerably more ..
  3. pmc Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
    Wei Chen
    Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
    Nature 490:278-82. 2012
    ..These results should stimulate further research into the development of a cell-based therapy for deafness...
  4. pmc Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss
    Hainan Lang
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3541-50. 2006
    ..A possible mechanism underlying this protection is that the NFkappaB activity may help to maintain calcium homeostasis in SGNs...
  5. pmc Dynamic range adaptation to sound level statistics in the auditory nerve
    Bo Wen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Neurosci 29:13797-808. 2009
    ..These findings suggest that adaptive processing of sound levels first occurs in the auditory periphery and is enhanced along the auditory pathway...
  6. pmc Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons
    JENNIFER A CHIKAR
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109 5616, United States
    Hear Res 245:24-34. 2008
    ..These results indicate that the changes in the anatomy of the auditory nerve induced by the combination of Ad.BDNF inoculation and the electrical stimulation used for testing improved functional measures of CI performance...
  7. ncbi Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans
    John J Guinan
    Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 27:589-607. 2006
    ..Monitoring MOC effects in humans using OAEs should continue to provide valuable insights into the role of MOC efferents and may also provide clinical benefits...
  8. pmc A phenomenological model of the synapse between the inner hair cell and auditory nerve: long-term adaptation with power-law dynamics
    Muhammad S A Zilany
    Department of Biomedical Engineering, University of Rochester, NY 14642, USA
    J Acoust Soc Am 126:2390-412. 2009
    ....
  9. ncbi Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve
    Zhengqing Hu
    Center for Hearing and Communication Research, and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1026:68-73. 2004
    ..The results demonstrate not only the survival and migration of xenografted DRG neurons and stem cells along the adult auditory nerve but also the feasibility of a cell replacement therapy in the degenerated auditory system...
  10. ncbi Auditory neuropathy characteristics in children with cochlear nerve deficiency
    Craig A Buchman
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ear Hear 27:399-408. 2006
    To describe a group of children exhibiting electrophysiologic responses characteristic of auditory neuropathy (AN) who were subsequently identified as having absent or small cochlear nerves (i.e., cochlear nerve deficiency).
  11. pmc Envelope coding in auditory nerve fibers following noise-induced hearing loss
    Sushrut Kale
    Weldon School of Biomedical Engineering, Purdue University, 500 Oval Drive, West Lafayette, IN 47907, USA
    J Assoc Res Otolaryngol 11:657-73. 2010
    ..Overall, these data suggest the need to consider the relative effects of SNHL on envelope and fine-structure coding in evaluating perceptual deficits in temporal processing of complex stimuli...
  12. pmc Response patterns to sound associated with labeled globular/bushy cells in cat
    W S Rhode
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Neuroscience 154:87-98. 2008
    ..5-2 ms notch after the initial spike, to an onset pattern with a low-sustained rate. They can represent low frequency tones and amplitude modulated signals exceptionally well with a temporal code...
  13. pmc A phenomenological model of peripheral and central neural responses to amplitude-modulated tones
    Paul C Nelson
    Department of Bioengineering and Neuroscience and Institute for Sensory Research, Syracuse University, Syracuse, New York 13244, USA
    J Acoust Soc Am 116:2173-86. 2004
    ....
  14. ncbi Outcomes in nontumor adults fitted with the auditory brainstem implant: 10 years' experience
    Vittorio Colletti
    ENT Department, University of Verona, Verona, Italy
    Otol Neurotol 30:614-8. 2009
    ..This study presents results from up to 10 years in adults, with analysis based on cause...
  15. pmc Cochlear efferent feedback balances interaural sensitivity
    Keith N Darrow
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, Massachusetts 02114, USA
    Nat Neurosci 9:1474-6. 2006
    ..Thus, lateral olivocochlear feedback maintains the binaural balance in neural excitability required for accurate localization of sounds in space...
  16. ncbi Human frequency-following response: representation of pitch contours in Chinese tones
    Ananthanarayan Krishnan
    Auditory Electrophysiology Laboratory, Department of Audiology and Speech Sciences, Purdue University, West Lafayette, IN 47907 2038, USA
    Hear Res 189:1-12. 2004
    ..These FFR findings support the viability of early, population-based 'predominant interval' representations of pitch in the auditory brainstem that are based on temporal patterns of phase-locked neural activity...
  17. ncbi Spontaneous activity of auditory-nerve fibers: insights into stochastic processes at ribbon synapses
    Peter Heil
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    J Neurosci 27:8457-74. 2007
    ..Our findings also constitute an essential step toward a better understanding of the spike-train representation of time-varying stimuli initiated at this synapse, and thus of the fundamentals of temporal coding in the auditory pathway...
  18. pmc Phase-locked responses to tones of chinchilla auditory nerve fibers: implications for apical cochlear mechanics
    Andrei N Temchin
    Hugh Knowles Center Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Assoc Res Otolaryngol 11:297-318. 2010
    ....
  19. pmc Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies
    Jeannie H Reyes
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci 28:12622-31. 2008
    ..This is the first study to report a high percentage of ES cell differentiation into a glutamatergic phenotype and sets the stage for cell replacement of auditory nerve...
  20. pmc Wiener kernels of chinchilla auditory-nerve fibers: verification using responses to tones, clicks, and noise and comparison with basilar-membrane vibrations
    Andrei N Temchin
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Neurophysiol 93:3635-48. 2005
    ....
  21. ncbi Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion
    Helge Rask-Andersen
    Department of Otosurgery, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Hear Res 203:180-91. 2005
    ..Transplantation of progenitor cells together with established means to induce neural differentiation and fiber growth may facilitate strategies for better repair and treatment of auditory neuronal damage...
  22. ncbi Imaging findings of cochlear nerve deficiency
    Christine M Glastonbury
    Department of Radiology, University Hospital, Salt Lake City, UT, USA
    AJNR Am J Neuroradiol 23:635-43. 2002
    ..Absence or reduction in caliber of the cochlear nerve (deficiency) has been described in association with congenital sensorineural hearing loss (SNHL)...
  23. ncbi Human frequency-following responses: representation of steady-state synthetic vowels
    Ananthanarayan Krishnan
    Auditory Electrophysiology Laboratory, Department of Audiology and Speech Sciences, Purdue University, W Lafayette, IN 47907, USA
    Hear Res 166:192-201. 2002
    ....
  24. pmc Neural representation of spectral and temporal information in speech
    Eric D Young
    Department of Biomedical Engineering, Centre for Hearing and Balance, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Philos Trans R Soc Lond B Biol Sci 363:923-45. 2008
    ..However, it is probable that the form of the representation at the auditory cortex is fundamentally different from that at lower levels, in that stimulus features other than the distribution of energy across frequency are analysed...
  25. ncbi Recording and analysis of electrically evoked compound action potentials (ECAPs) with MED-EL cochlear implants and different artifact reduction strategies in Matlab
    Andreas Bahmer
    University of Frankfurt Main, Clinic for Otolaryngology, Audiological Acoustics, 60590 Frankfurt, Germany
    J Neurosci Methods 191:66-74. 2010
    ..ECAP recordings of a human subject with three different artifact reduction methods (alternating, Miller modified masker-probe, triphasic pulses) are presented and compared...
  26. ncbi Transplantation of conditionally immortal auditory neuroblasts to the auditory nerve
    Tetsuji Sekiya
    Department of Otolaryngology, Kyoto University Graduate School of Medicine, Sakyou ku, Kyoto, 606 8507 Japan
    Eur J Neurosci 25:2307-18. 2007
    ....
  27. ncbi Panoramic measurements of the apex of the cochlea
    Marcel van der Heijden
    Laboratory of Auditory Neurophysiology, K U Leuven Medical School, B 3000 Leuven, Belgium
    J Neurosci 26:11462-73. 2006
    ....
  28. pmc Fast negative feedback enables mammalian auditory nerve fibers to encode a wide dynamic range of sound intensities
    Mark Ospeck
    PLoS ONE 7:e32384. 2012
    ..The ANF spike generator remains very sensitive to threshold currents, but efferent feedback is able to lower its gain in response to noise...
  29. ncbi Effect of topically applied basic fibroblast growth factor on injured cochlear nerve
    Tetsuji Sekiya
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosurgery 52:900-7; discussion 907. 2003
    ..To challenge such a pessimistic view, we investigated whether pharmacological interventions with basic fibroblast growth factor (bFGF) could ameliorate trauma-induced cochlear nerve degeneration.
  30. pmc Stem cell transplantation for auditory nerve replacement
    Richard A Altschuler
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150W Medical Center Drive, Ann Arbor, MI 48109 5616, United States
    Hear Res 242:110-6. 2008
    ....
  31. pmc Temporal response properties of the auditory nerve: data from human cochlear-implant recipients
    Michelle L Hughes
    Boys Town National Research Hospital, Lied Learning and Technology Center, 425 North 30th Street, Omaha, NE 68131, USA
    Hear Res 285:46-57. 2012
    ..Differences in temporal response properties across the cochlea within subjects may have implications for developing new speech-processing strategies that employ varied rates across the array...
  32. pmc Effect of auditory-nerve response variability on estimates of tuning curves
    Ananthakrishna Chintanpalli
    Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive, West Lafayette, Indiana 47907, USA
    J Acoust Soc Am 122:EL203-9. 2007
    ..Errors in estimates of CF, which decreased from +/-0.2 octaves at low frequencies to +/-0.05 octaves at high frequencies, are significant for studies of spatiotemporal coding...
  33. ncbi The convergence of cochlear implantation with induced pluripotent stem cell therapy
    Niliksha Gunewardene
    Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia
    Stem Cell Rev 8:741-54. 2012
    ....
  34. ncbi Cochlear implantation in children with labyrinthine anomalies and cochlear nerve deficiency: implications for auditory brainstem implantation
    Craig A Buchman
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Laryngoscope 121:1979-88. 2011
    Compare outcomes among children with inner ear malformations and/or cochlear nerve deficiency (CND) who have received a cochlear implant (CI).
  35. ncbi Relationship between the auditory brainstem response and auditory nerve thresholds in cats with hearing loss
    E M Ngan
    Department of Otolaryngology-HNS, Johns Hopkins University, 505 Traylor Research Building, 720 Rutland Avenue, Baltimore, MD 21205-2195, USA
    Hear Res 156:44-52. 2001
    ..Across varying degrees of hearing loss, the ABR maintained a systematic relationship to auditory nerve fiber thresholds, and therefore has the potential to be used as a functional assay of cochlear pathology...
  36. ncbi Variable long-term outcomes from cochlear implantation in children with hypoplastic auditory nerves
    Jane Bradley
    Royal National Throat Nose and Ear Hospital, London WC1X 8DA, UK
    Cochlear Implants Int 9:34-60. 2008
    ..In specific cases it may be appropriate to offer a cochlear implant to a child with hypoplastic auditory nerves but careful counselling of the family about likely outcomes is essential...
  37. ncbi Forward masking as a method of measuring place specificity of neural excitation in cochlear implants: a review of methods and interpretation
    Colette M McKay
    School of Psychological Sciences, University of Manchester, Oxford Road, Manchester, M33 3GH, United Kingdom
    J Acoust Soc Am 131:2209-24. 2012
    ..The effects of unit of measurement on specificity measures and the effects of subject listening strategy on the forward masked functions are also discussed...
  38. pmc Enhanced auditory neuron survival following cell-based BDNF treatment in the deaf guinea pig
    Lisa N Pettingill
    The Bionic Ear Institute, East Melbourne, Victoria, Australia
    PLoS ONE 6:e18733. 2011
    ....
  39. ncbi Transmission of phase-coupling accuracy from the auditory nerve to spherical bushy cells in the Mongolian gerbil
    Susanne Dehmel
    Faculty of Biosciences, University of Leipzig, Talstrasse 33, 04103 Leipzig, Germany
    Hear Res 268:234-49. 2010
    ..These results suggest that the phase-coupling accuracy is improved in a subpopulation of SBCs during transmission from the auditory nerve to the SBCs by reduction of spike rates...
  40. pmc Auditory brainstem responses predict auditory nerve fiber thresholds and frequency selectivity in hearing impaired chinchillas
    Kenneth S Henry
    Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN 47907, USA
    Hear Res 280:236-44. 2011
    ..Furthermore, comparisons of ABR wave I latency to normative data at the same SL may prove useful for detecting and characterizing loss of cochlear frequency selectivity...
  41. ncbi Vascular compression of the cochlear nerve and tinnitus: a pathophysiological investigation
    Dirk De Ridder
    TRI Tinnitus Clinic, BRAI2N and Department of Neurosurgery, University Hospital Antwerp, Edegem, Belgium
    Acta Neurochir (Wien) 154:807-13. 2012
    ..Chronic microvascular compressions of the eighth nerve induce a slowing down of signal transmission in the auditory nerve, electrophysiologically characterized by IPL I-III prolongation...
  42. ncbi A model for implanting neuronal tissue into the cochlea
    Petri Olivius
    Department of Clinical Neuroscience, Section of Otorhinolaryngology, Center for Hearing and Communication Research, Karolinska Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Brain Res Brain Res Protoc 12:152-6. 2004
    ....
  43. ncbi Variations in carrier pulse rate and the perception of amplitude modulation in cochlear implant users
    Tim Green
    University College London, Speech Hearing and Phonetic Sciences, London, United Kingdom
    Ear Hear 33:221-30. 2012
    ....
  44. ncbi A cell therapy approach to substitute neural elements in the inner ear
    Mats Ulfendahl
    Karolinska Institutet, Center for Hearing and Communication Research, Department of Otolaryngology, Karolinska University Hospital, S 177 76 Stockholm, Sweden
    Physiol Behav 92:75-9. 2007
    ..In addition, it is possible that the physical properties of the cochlea, e.g., fluid-filled compartments and very limited space for cell proliferation, are unfavorable, at least in the normal cochlea...
  45. pmc Disruption of lateral efferent pathways: functional changes in auditory evoked responses
    Colleen G Le Prell
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109 0506, USA
    J Assoc Res Otolaryngol 4:276-90. 2003
    ..They also confirm the suggestion that changes in single-unit auditory nerve activity after cutting the olivocochlear bundle are probably a consequence of disrupting the more lateral of the two olivocochlear efferent pathways...
  46. ncbi Are cochlear implant patients suffering from perceptual dissonance?
    Gerald E Loeb
    Department of Biomedical Engineering, Viterbi School of Engineering and A E Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles 90089 1112, USA
    Ear Hear 26:435-50. 2005
    ....
  47. ncbi Physiological effects of auditory nerve myelinopathy in chinchillas
    Mohamed M El-Badry
    Otolaryngology Department, Audiology Unit, El Minia University Hospitals, El Minia University, El Minia, Egypt
    Eur J Neurosci 25:1437-46. 2007
    ..The results support auditory nerve myelinopathy as a possible pathomechanism of auditory neuropathy but indicate that myelinopathy must be severe before physiological measures are affected...
  48. ncbi Internal auditory canal morphology in children with cochlear nerve deficiency
    Oliver F Adunka
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7600, USA
    Otol Neurotol 27:793-801. 2006
    To describe the internal auditory canal (IAC) and inner ear morphologic characteristics of children with cochlear nerve (CN) deficiency.
  49. ncbi The clinical application of potentials evoked from the peripheral auditory system
    Charles A Miller
    Department of Otolaryngology, University of Iowa, United States
    Hear Res 242:184-97. 2008
    ..Future research directions, which will likely involve the integration of various dimensions of the electrically evoked response that have been studied in isolation, are also suggested...
  50. pmc Site of cochlear stimulation and its effect on electrically evoked compound action potentials using the MED-EL standard electrode array
    Stefan Brill
    Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Wurzburg, Germany
    Biomed Eng Online 8:40. 2009
    ..The aim of this study is to determine if certain properties of ECAP recordings vary, depending on the stimulation site in the cochlea...
  51. pmc Chronic reduction of endocochlear potential reduces auditory nerve activity: further confirmation of an animal model of metabolic presbyacusis
    Hainan Lang
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Charleston, SC 29425, USA
    J Assoc Res Otolaryngol 11:419-34. 2010
    ..These results suggest that dysfunction of the cochlear lateral wall and subsequent chronic reduction in the EP can directly affect the activity patterns of primary auditory neurons in a manner similar to that seen in aged gerbils...
  52. ncbi Aplasia of the cochlear nerve: a temporal bone study
    E G Nelson
    Section of Otolaryngology-Head and Neck Surgery, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 1035, Chicago, IL 60637, USA
    Otol Neurotol 22:790-5. 2001
    OBJECTIVE: The purpose of this study was to evaluate the temporal bone findings in individuals with cochlear nerve aplasia. STUDY DESIGN: Retrospective case review...
  53. pmc Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans
    Fred H Linthicum
    House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 30:418-422. 2009
    ..To demonstrate that contrary to what occurs in animals, neuron loss in the human spiral ganglion is not in proportion to organ of Corti hair or supporting cell loss...
  54. pmc Response characteristics in the apex of the gerbil cochlea studied through auditory nerve recordings
    Corstiaen P C Versteegh
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    J Assoc Res Otolaryngol 12:301-16. 2011
    ..Overall, our data suggest that mechanical responses in the apex of the cochlea are considerably nonlinear and that these nonlinearities are of a different character than those known from the base of the cochlea...
  55. pmc Threshold tuning curves of chinchilla auditory-nerve fibers. I. Dependence on characteristic frequency and relation to the magnitudes of cochlear vibrations
    Andrei N Temchin
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Neurophysiol 100:2889-98. 2008
    ..At the apex of the chinchilla cochlea, frequency tuning is substantially sharper for ANFs than for available recordings of organ of Corti vibrations...
  56. pmc Correct tonotopic representation is necessary for complex pitch perception
    Andrew J Oxenham
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:1421-5. 2004
    ..The experiments demonstrate that tonotopic representation is crucial to complex pitch perception and provide a new tool in the search for the neural basis of pitch...
  57. pmc Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 25:6857-68. 2005
    ..6 and Nav1.2 in the cochlear ganglion, cochlear nerve, and organ of Corti, including the type I and type II ganglion cells. In most type I ganglion cells, Nav1...
  58. ncbi Interaural time sensitivity dominated by cochlea-induced envelope patterns
    Philip X Joris
    Laboratory of Auditory Neurophysiology, Medical School, Campus Gasthuisberg, K U Leuven, B 3000 Leuven, Belgium
    J Neurosci 23:6345-50. 2003
    ..These results suggest that internally generated envelopes play a more important role in binaural hearing than is commonly thought...
  59. ncbi Dopamine inhibition of auditory nerve activity in the adult mammalian cochlea
    J Ruel
    , Laboratoire de Neurobiologie de l'Audition, 71 rue de Navacelles, 34090 Montpellier, France
    Eur J Neurosci 14:977-86. 2001
    ..Results suggest that dopamine may exert a tonic inhibition of the auditory nerve activity. Removal of this tonic inhibition results in the development of early signs of excitotoxicity...
  60. pmc Variation in the phase of response to low-frequency pure tones in the guinea pig auditory nerve as functions of stimulus level and frequency
    Alan R Palmer
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
    J Assoc Res Otolaryngol 10:233-50. 2009
    ..This null frequency was often not at the CF. At stimulation frequencies below the null, there was a progressive lag with sound level and a progressive lead for stimulation frequencies above the null. This was maximally 0.2 cycles...
  61. ncbi Comparison of bandwidths in the inferior colliculus and the auditory nerve. I. Measurement using a spectrally manipulated stimulus
    Myles Mc Laughlin
    Laboratory of Auditory Neurophysiology, Medical School, Campus Gasthuisberg, Leuven, Belgium
    J Neurophysiol 98:2566-79. 2007
    ..We find that both AN and IC filter BW depend on characteristic frequency, but that there is no difference in mean BW between the AN and IC...
  62. pmc Binaural and cochlear disparities
    Philip X Joris
    Laboratory of Auditory Neurophysiology, University of Leuven, Campus Gasthuisberg, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 103:12917-22. 2006
    ..These findings suggest that cochlear disparities make an important contribution to the internal delays observed in binaural neurons...
  63. pmc Connections between the facial, vestibular and cochlear nerve bundles within the internal auditory canal
    Omer Ozdogmus
    Marmara University School of Medicine, Department of Anatomy, Istanbul, Turkey
    J Anat 205:65-75. 2004
    ..The present study offers morphometric and scanning electron microscopic data on the fibre connections of the nerves of the IAC...
  64. pmc In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response
    Sanjiv B Amin
    Department of Pediatrics, Division of Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Pediatr 156:377-81. 2010
    ..To determine whether cord ferritin (CF) concentration, an index of in utero iron status, is associated with auditory neural maturation in premature infants...
  65. pmc Influence of supporting cells on neuronal degeneration after hair cell loss
    Mitsuru Sugawara
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 6:136-47. 2005
    In sensorineural hearing loss, hair cell loss is often followed by loss of cochlear nerve fibers, which can continue for years after the insult...
  66. pmc Threshold tuning curves of chinchilla auditory nerve fibers. II. Dependence on spontaneous activity and relation to cochlear nonlinearity
    Andrei N Temchin
    Dept of Communication Sciences and Disorders, Northwestern Univ, 2240 Campus Dr, Evanston, IL 60208 3550, USA
    J Neurophysiol 100:2899-906. 2008
    ..It is shown here that this dependence of tuning on spontaneous rates is consistent with a previously unnoticed nonmonotonic dependence on iso-velocity criterion of the frequency tuning of basilar membrane vibrations...
  67. ncbi Preliminary results of auditory brainstem implantation in prelingually deaf children with inner ear malformations including severe stenosis of the cochlear aperture and aplasia of the cochlear nerve
    Levent Sennaroglu
    Department of Otolaryngology, Hacettepe University Medical Faculty, Ankara, Turkey
    Otol Neurotol 30:708-15. 2009
    ..The aim of our study is to present the results of 11 children where auditory brainstem implantation (ABI) was successfully performed to restore hearing...
  68. ncbi Temporal processing from the auditory nerve to the medial nucleus of the trapezoid body in the rat
    A G Paolini
    Department of Otolarynology, The University of Melbourne, Royal Victoria Eye and Ear Hospital, East Melbourne, Australia
    Hear Res 159:101-16. 2001
    ..Our results suggest that AVCN PL(N) units, representing globular bushy cells, are specialised for enhancing the temporal code at low frequencies and relaying this information to principal cells of the MNTB...
  69. ncbi Firing patterns of type II spiral ganglion neurons in vitro
    Michael A Reid
    Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08854 8082, USA
    J Neurosci 24:733-42. 2004
    ..In particular, the type II neuron properties are consistent with cells in other sensory systems that receive convergent synaptic input for high-sensitivity stimulus detection...
  70. ncbi Temporal properties of responses to broadband noise in the auditory nerve
    Dries H G Louage
    Laboratory of Auditory Neurophysiology, Medical School, K U Leuven, B 3000 Leuven, Belgium
    J Neurophysiol 91:2051-65. 2004
    ..We conclude that the combined use of broadband noise and SAC analysis allow a more general characterization of temporal behavior than periodic stimuli and Fourier analysis...
  71. ncbi Wiener-kernel analysis of responses to noise of chinchilla auditory-nerve fibers
    Alberto Recio-Spinoso
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Neurophysiol 93:3615-34. 2005
    ..Thus onset delays, frequency glides, and near-CF group delays could be estimated for auditory-nerve fibers innervating the entire length of the chinchilla cochlea...
  72. ncbi Searching for the time constant of neural pitch extraction
    L Wiegrebe
    Zoologisches Institut der Universität München, Germany
    J Acoust Soc Am 109:1082-91. 2001
    ....
  73. ncbi Functional correlates of characteristic frequency in single cochlear nerve fibers of the Mongolian gerbil
    K K Ohlemiller
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208
    J Comp Physiol A 167:329-38. 1990
    ..thresholds encountered, even when data from many animals were combined, rarely exceeded 20 dB, suggesting that cochlear nerve responses obtained from this species display little inter-animal variability...
  74. ncbi Unique expression of connexins in the human cochlea
    Wei Liu
    Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden
    Hear Res 250:55-62. 2009
    ..Their potential role in the processing of human auditory nerve signaling as well as non-GJ roles of the connexins in human cochlea is discussed...
  75. ncbi Cochlear nerve demyelination causes prolongation of wave I latency in ABR of the myelin deficient (md) rat
    Tetsufumi Ito
    Department of Anatomy, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Hear Res 191:119-24. 2004
    ..ABRs showed a marked prolongation not only wave II-IV latencies but also wave I latency. Cochlear nerve fibers near the modiolus lost their myelin halfway into the internal auditory canal...
  76. ncbi Delivery of neurotrophin-3 to the cochlea using alginate beads
    Farnoosh Noushi
    University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
    Otol Neurotol 26:528-33. 2005
    ..The aim of this study was to design a novel cochlear neurotrophin (NT) delivery system for the rescue of auditory neurons after ototoxicity-induced deafening...
  77. ncbi Neural encoding in the human brainstem relevant to the pitch of complex tones
    Ananthanarayan Krishnan
    Department of Speech Language Hearing Sciences, Purdue University, 1353 Heavilon Hall, 500 Oval Drive, West Lafayette, IN 47907 2038, USA
    Hear Res 275:110-9. 2011
    ..The scalp recorded FFR may provide for a non-invasive analytic tool to evaluate neural encoding of complex sounds in humans...
  78. ncbi Brainstem auditory-evoked potentials in iron-deficiency anemia
    S U Sarici
    Department of Pediatrics, , Ankara, Turkey
    Pediatr Neurol 24:205-8. 2001
    ..Although we could not demonstrate a hearing loss in infants with moderate iron-deficiency anemia in this study, the relationship between severe iron-deficiency anemia and hearing loss or auditory dysfunction remains to be determined...
  79. ncbi Apparent cochlear nerve aplasia: to implant or not to implant?
    Frank M Warren
    Division of Otolaryngology, Head and Neck Surgery, University of Utah, Salt Lake City, Utah 84132, U S A
    Otol Neurotol 31:1088-94. 2010
    To describe the imaging findings and clinical outcomes of children with apparent cochlear nerve aplasia undergoing cochlear implantation.
  80. pmc The volley theory and the spherical cell puzzle
    P X Joris
    Laboratory of Auditory Neurophysiology, K U Leuven, Campus GHB O and N2, Herestraat 49 bus 1021, B 3000 Leuven, Belgium
    Neuroscience 154:65-76. 2008
    ....
  81. ncbi Comparison of bandwidths in the inferior colliculus and the auditory nerve. II: Measurement using a temporally manipulated stimulus
    Myles Mc Laughlin
    Laboratory of Auditory Neurophysiology, Medical School, K U Leuven, Campus Gasthuisberg O and N 2, Herestraat 49 bus 1021, B 3000 Leuven, Belgium
    J Neurophysiol 100:2312-27. 2008
    ..We conclude that binaural sensitivity is more dependent on correlation sensitivity than has hitherto been appreciated and that the mechanisms underlying correlation sensitivity should be addressed in future studies...
  82. ncbi Functional anatomy of the human cochlear nerve and its role in microvascular decompressions for tinnitus
    Dirk De Ridder
    Department of Neurosurgery and Otorhinolaryngology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium
    Neurosurgery 54:381-8; discussion 388-90. 2004
    The functional anatomy (i.e., tonotopy) of the human cochlear nerve is unknown...
  83. ncbi Microvascular decompression of cochlear nerve for tinnitus incapacity: pre-surgical data, surgical analyses and long-term follow-up of 15 patients
    Nicolas Guevara
    Department of Otorhinolaryngology, CHU de Nice, Hopital Pasteur, 30, avenue de la Voie Romaine, B P 69, 06002 Nice, Cedex 1, France
    Eur Arch Otorhinolaryngol 265:397-401. 2008
    ..However, cochlear nerve compression syndrome by vascular loop is still a controversial topic...
  84. pmc Subthreshold K+ channel dynamics interact with stimulus spectrum to influence temporal coding in an auditory brain stem model
    Mitchell L Day
    Center for Neural Science, New York University, New York, NY, USA
    J Neurophysiol 99:534-44. 2008
    ....
  85. ncbi A model of the electrically excited human cochlear neuron. I. Contribution of neural substructures to the generation and propagation of spikes
    F Rattay
    TU BioMed, Vienna University of Technology, Austria
    Hear Res 153:43-63. 2001
    ..Comparing the reactions of a human and cat cochlear neuron, we find differences in spiking behavior, e.g. peripherally and centrally evoked spikes arrive with a time difference of about 400 mus in man and 200 mus in cat...
  86. pmc Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapse
    Lisa Grant
    The Johns Hopkins School of Medicine, Department of Otolaryngology Head and Neck Surgery, Baltimore, Maryland 21205, USA
    J Neurosci 30:4210-20. 2010
    ..We propose that the relative contribution of two modes of multivesicular release, generating monophasic and multiphasic EPSCs, may underlie fundamental characteristics of auditory nerve fibers...
  87. ncbi Electrical stimulation of the cochlear nerve in rats: analysis of c-Fos expression in auditory brainstem nuclei
    Makoto Nakamura
    Department of Neurosurgery, Klinikum Hannover Nordstadt, Hannover, Germany
    Brain Res 1031:39-55. 2005
    ..functional activation of central auditory brainstem nuclei in response to direct electrical stimulation of the cochlear nerve using c-Fos immunoreactivity as a marker for functional mapping...
  88. ncbi Intracochlear and extracochlear ECAPs suggest antidromic action potentials
    Charles A Miller
    Department of Otolaryngology, Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21201 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Hear Res 198:75-86. 2004
    ..Compared with the feline ECAPs, the human potentials had smaller amplitudes and longer latencies. It is not clear what underlies these differences, although several factors are considered...
  89. pmc Effect of interphase gap and pulse duration on electrically evoked potentials is correlated with auditory nerve survival
    Pavel Prado-Guitierrez
    Department of Otolaryngology, The University of Melbourne, Australia
    Hear Res 215:47-55. 2006
    ..These results may provide a tool for investigating the contribution of auditory nerve survival to clinical performance among cochlear implant subjects...
  90. ncbi Delayed neurotrophic treatment preserves nerve survival and electrophysiological responsiveness in neomycin-deafened guinea pigs
    Takahiko Yamagata
    Center for Hearing and Communication Research and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 78:75-86. 2004
    ..It is noteworthy that this same degree of ganglion cell loss, secondary to receptor damage, is typically observed after a period equivalent to some years of deafness in humans...
  91. ncbi 3-T imaging of the cochlear nerve and labyrinth in cochlear-implant candidates: 3D fast recovery fast spin-echo versus 3D constructive interference in the steady state techniques
    John I Lane
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    AJNR Am J Neuroradiol 25:618-22. 2004
    ..5 T is often performed by using three-dimensional (3D) fast spin-echo or T2* techniques. We evaluated both techniques at 3 T in the preoperative assessment of patients being considered for cochlear implants...
  92. ncbi Measuring the refractoriness of the electrically stimulated auditory nerve
    Andre Morsnowski
    Cochlear Implant Centrum Schleswig Kiel, Department of Oto Rhino Laryngology, Head and Neck Surgery, Christian Albrechts University of Kiel, Kiel, Germany
    Audiol Neurootol 11:389-402. 2006
    ..This can bias the measurement of ECAP thresholds. Additionally, the shape of standard forward masking recovery functions was explained by the influence of latency shift of the neural response...
  93. ncbi Contributions of ion conductances to the onset responses of octopus cells in the ventral cochlear nucleus: simulation results
    Y Cai
    Developmental Auditory Physiology Laboratory, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Neurophysiol 83:301-14. 2000
    ..On the other hand, I(h), which is activated during hyperpolarization, does not play a large role in the basic onset response pattern but may regulate response threshold through its contribution to the membrane conductance...
  94. pmc Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti
    C Eduardo Corrales
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Neurobiol 66:1489-500. 2006
    ..degeneration, we injected EYFP-expressing embryonic stem cell-derived mouse neural progenitor cells into the cochlear nerve trunk in immunosuppressed animals 1 week after destroying the cochlear nerve (spiral ganglion) cells while ..
  95. pmc Time course and calcium dependence of transmitter release at a single ribbon synapse
    Juan D Goutman
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 824, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:16341-6. 2007
    ..By varying Ca(2+) buffering in the IHC, we further investigate how Ca(2+) channel and Ca(2+) sensor at this synapse might relate...
  96. ncbi Effect of deep insertion of the cochlear implant electrode array on pitch estimation and speech perception
    Jafar Hamzavi
    Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria
    Acta Otolaryngol 126:1182-7. 2006
    ..Deeply inserted electrodes offer the possibility that apical stimulation may improve speech performances. Therefore, deep insertion is reasonable and should be performed in patients with profound or total hearing loss...
  97. ncbi The temporal representation of speech in a nonlinear model of the guinea pig cochlea
    Stephen D Holmes
    School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Acoust Soc Am 116:3534-45. 2004
    ....
  98. ncbi A simple two-component model of the electrically evoked compound action potential in the human cochlea
    W K Lai
    ENT Department, University Hospital, Zurich, Switzerland
    Audiol Neurootol 5:333-45. 2000
    ..This information could be useful for determining optimal speech coding parameters for cochlear implant users on an individual basis...
  99. ncbi Ensemble spontaneous activity in the guinea-pig cochlear nerve
    G D Searchfield
    Discipline of Audiology and Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, New Zealand
    Hear Res 192:23-35. 2004
    ..from the round window (RW) of the cochlea is referred to as the ensemble spontaneous activity (ESA) of the cochlear nerve. The ESA is considered to represent the summed spontaneous activity of single fibers of the auditory nerve and ..
  100. ncbi Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurophysiol 90:2941-9. 2003
    ..This constitutes the most direct evidence to date for a functional role of the lateral OC system in the auditory periphery...
  101. ncbi Tuning and timing in the gerbil ear: Wiener-kernel analysis
    Edwin R Lewis
    Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA
    Hear Res 174:206-21. 2002
    ..Eigen or singular-value decomposition of the second-order Wiener kernel allows us to separate excitatory and suppressive effects, and to determine precisely the timing of the latter...

Research Grants78

  1. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2006
    ..The net effect of these hair cell actions is the production of discharge activity in the cochlear nerve. Tools are now available to dissect the processes in each of these cellular compartments and examine their ..
  2. NEUROGENESIS IN THE AUDITORY SYSTEM
    DONALD MOREST; Fiscal Year: 2005
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as major incurable disorders today...
  3. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2004
    ..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
  4. ACTIVITY-DEPENDENT DEVELOPMENT OF CALCIUM HOMEOSTASIS
    Lance Zirpel; Fiscal Year: 2002
    ..how neurons in the cochlear nucleus respond to the onset and increasing levels of afferent input from the cochlear nerve during development with the implementation of mechanisms to regulate intracellular ion homeostasis...
  5. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 2001
    ..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
  6. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
  7. OBJECTIVE MEASURE OF LOW-FREQUENCY INNER EAR FUNCTION
    JEFFERY LICHTENHAN; Fiscal Year: 2013
    ..functional measure - the auditory nerve overlapped waveform (ANOW) - which is thought to originate from apical cochlear nerve fibers in response to low-frequency stimuli of low- to moderate-level...
  8. 2013 and 2015 Conferences on Implantable Auditory Prostheses
    Robert V Shannon; Fiscal Year: 2013
    ..that stimulates the cochlear nucleus, can provide speech understanding in children and adults who have no cochlear nerve. These advances have benefitted substantially from the collective efforts of researchers in a broad array of ..
  9. High resolution mapping of the Cochlear nerve using optical stimulation
    Jonathon Wells; Fiscal Year: 2009
    ..This research will focus on enhancing the performance of the cochlear implant to allow people to hear speech in a crowded room. ..
  10. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 2000
    ..Cochlear implants have been remarkably successful in restoring hearing to deaf patients with residual cochlear nerve function...
  11. POSTNATAL AUDITORY FUNCTION DEVELOPMENT
    GEORGE STRAIN; Fiscal Year: 1991
    ..Cochlear microphonic, summating potential, cochlear nerve action potential, and brainstem auditory evoked potential will be recorded using electrodes surgically ..
  12. High resolution mapping of the Cochlear nerve using optical stimulation
    Mark Bendett; Fiscal Year: 2006
    ..This research will focus on enhancing the performance of the cochlear implant to allow people to hear speech in a crowded room and even to hear music. [unreadable] [unreadable] [unreadable]..
  13. SPEECH CODING IN THE POSTEROVENTRAL COCHLEAR NUCLEUS
    Steven Greenberg; Fiscal Year: 1992
    The neural mechanisms underlying the processing of speech beyond the cochlear nerve are virtually unknown...
  14. INNER EAR AND CENTRAL AUDITORY DEVELOPMENT
    DONALD MOREST; Fiscal Year: 2000
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as the major incurable otological disorders today, despite recent advances with cochlear prostheses...
  15. NEUROANATOMICAL DEVELOPMENT OF THE AUDITORY SYSTEM
    Laura Schweitzer; Fiscal Year: 1991
    ..The methods and specific aims can be summarized as follows: 1) Using horseradish peroxidase, individual cochlear nerve axons will be filled and their images reconstructed to study the development of the topographic organization ..
  16. DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICS
    David Mills; Fiscal Year: 2003
    ..manipulation of the EP, with particular attention to the proposed adaptation process; 4) the effect on the normal cochlear function, and on functional recovery to EP change, of a block on activity of the cochlear nerve.
  17. Auditory nerve responses to electric pulse trains
    Charles Miller; Fiscal Year: 2009
    ..We expect the results of this work will guide future designs of cochlear-implant speech processors so that modulated stimuli can be better tailored to the encoding capacity of the user's auditory nerve. ..
  18. PERCEPTION AND PROCESSING OF COMPLEX BIOLOGICAL SIGNALS
    JOHN MIDDLEBROOKS; Fiscal Year: 2002
    ..new understanding of cortical mechanisms of complex signal processing, the processes underlying temporary and permanent hearing loss, the excitotoxic damage of cochlear nerve fibers, and a genetic therapy to rescue those damaged cells.
  19. Cell survival and cell death in the auditory nerve
    Hainan Lang; Fiscal Year: 2008
    ..abstract_text> ..
  20. COCHLEAR MECHANICS
    WILLIAM RHODE; Fiscal Year: 2007
    ..studies is to provide the database for interpreting observations obtained from physiological studies of the cochlear nerve or from psychophysical studies from which data are subsequent to transformations engendered by the auditory ..
  21. SYMPOSIA FOR ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
    JUDY DUBNO; Fiscal Year: 2003
    ..abstract_text> ..
  22. NEURAL REPRESENTATION OF SPEECH WITH SENSORINEURAL LOSS
    Eric Young; Fiscal Year: 2009
    ..These data will be used to connect human perceptual data with data on cat auditory neurophysiology. ..
  23. JEM-123O Electron Microscope
    DAVID RYUGO; Fiscal Year: 2003
    ..It will serve to catalyze interdisciplinary discussions among users, provide a valuable teaching tool for our trainees, and enhance the progress of biomedical research on hearing, vision, and voice. ..
  24. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2008
    ..abstract_text> ..
  25. Signal Processing in Audition
    Fan Gang Zeng; Fiscal Year: 2009
    ..abstract_text> ..
  26. Training in the Neurobiology of Otorhinolaryngology
    James Saunders; Fiscal Year: 2007
    ..Research is conducted under the supervision of one of the trainers. We are requesting four predoctoral, three postdoctoral positions per year. [unreadable] [unreadable]..
  27. Improved efficacy of cochlear implants by directed regrowth of the auditory nerve
    JENNIFER CHIKAR; Fiscal Year: 2007
    ..The intent of this study is to improve the perception of sound from the implant and potentially provide the cochlear implant user with the ability to hear more complex sounds. [unreadable] [unreadable] [unreadable]..
  28. Function of hair cells regenerated by Atoh1
    MARK CRUMLING; Fiscal Year: 2007
    ..This is accomplished using molecular biological, electrophysiological, and audiological techniques to probe the inner ear for hallmarks of outer hair cell structure and function. [unreadable] [unreadable] [unreadable]..
  29. INTERVENTIONS TO PREVENT NOISE INDUCED HEARING LOSS
    JOSEF MILLER; Fiscal Year: 2007
    ..We will also determine if reduced blood flow potentiates NIHL, in vivo. These studies will define new interventions and synergies at sites along the apoptotic pathway to optimize the prevention of NIHL. ..
  30. Eph Signaling Auditory Brainstem Development
    KARINA CRAMER; Fiscal Year: 2007
    ..abstract_text> ..
  31. 11th International conference on cochlear implants in children
    Craig Buchman; Fiscal Year: 2007
    ..The purpose of this symposium is to continue this necessary and productive interaction. [unreadable] [unreadable] [unreadable]..
  32. CLINICAL MEASURES OF AUDITORY LINEAR/NONLINEAR PROCESSES
    MARK CHERTOFF; Fiscal Year: 2004
    ..abstract_text> ..
  33. TISSUE ENGINEERING IN THE INNER EAR
    JOSEF MILLER; Fiscal Year: 2005
    ....
  34. SINGLE-CELL MARKING STUDIES OF THE AUDITORY NERVE
    David K Ryugo; Fiscal Year: 2010
    ..Lastly, the new knowledge could contribute to improved treatment strategies for users of bilateral cochlear implants and impact considerations of auditory brainstem implants. ..
  35. ENCODING OF VOCAL SIGNALS IN THE AUDITORY SYSTEM
    Andrew H Bass; Fiscal Year: 2011
    ..with auditory; neuropathy/dys-synchrony.. '-.'...... ..
  36. STUDIES OF THE COCHLEAR NUCLEUS GRANULE CELL DOMAIN
    David K Ryugo; Fiscal Year: 2010
    ..As we learn about how the somatosensory system modulates hearing, we will gain insight into somatic tinnitus that could contribute to the design of treatment strategies and a better understanding of tinnitus in general. ..
  37. Auditory nerve encoding of speech with varied acoustics
    Hanna Stevens; Fiscal Year: 2003
    ..abstract_text> ..
  38. DEVELOPMENT OF A MIDDLE EAR BALLOON IMPLANT
    SAUMIL MERCHANT; Fiscal Year: 2003
    ..There is a large market potential for this implant, estimated at over 65,000 devices annually in the U.S. alone. ..
  39. CRCNS: Auditory Stream Segregation and the Cocktail Party Problem
    Shihab Shamma; Fiscal Year: 2007
    ..This project will also provide a rigorous foundation for the design and generation of new hypotheses in order to better understand the neural basis of active listening [unreadable] [unreadable]..
  40. Short-term synaptic plasticity and intensity coding in *
    KATRINA MACLEOD; Fiscal Year: 2008
    ..abstract_text> ..
  41. Complex Sound Segregation by Hearing-Impaired Listeners
    Jennifer Lentz; Fiscal Year: 2004
    ..Future work will be directed toward the cues that encourage good sound segregation, and therefore more normal analysis of spectral shape, to suggest new directions in amplification schemes. ..
  42. Physiological Studies of Age-Related Hearing Loss
    RICHARD SCHMIEDT; Fiscal Year: 2007
    ..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
  43. FUNCTIONAL EFFECTS OF DEAFNESS AND NEURAL STIMULATION
    BRYAN PFINGST; Fiscal Year: 2005
    ....
  44. Model for prediction of noise-induced hearing loss
    ROGER HAMERNIK; Fiscal Year: 2005
    ..The chinchilla model can be used as a template or a guide for developing a human model possibly from some of the existing human data from which current standards were developed. ..
  45. Effects of sensorineural loss on robust speech coding
    Michael Heinz; Fiscal Year: 2007
    ..The difficulty hearing-impaired listeners have in understanding speech in complex acoustic environments may be due in part to a reduced ability to segregate sound sources based on voice pitch. ..
  46. FEATURES OF STIMULATION IMPORTANT FOR ELECTRICAL HEARING
    BRYAN PFINGST; Fiscal Year: 2003
    ..abstract_text> ..
  47. 2008 Conference on Cell Replacement in the Inner Ear
    GEORGE GATES; Fiscal Year: 2008
    ..Current treatments for hearing loss involve sound amplification via hearing aids or direct stimulation of the cochlear nerve, bypassing the damaged sensory epithelium. There are no known treatments for loss of vestibular function...
  48. A statistical learning model for predicting noise-induced hearing loss in humans
    Roger P Hamernik; Fiscal Year: 2010
    ..Statistical learning models will be developed to achieve this goal. ..
  49. TRANSNEURONAL SIGNALS FOR AFFERENT REGULATION
    RICHARD HYSON; Fiscal Year: 2006
    ..Additional experiments will describe a relatively uncharacterized population of GABAergic cells in this system. ..
  50. AUDITORY PROCESSING OF TEMPORALLY-COMPLEX SOUNDS
    DONAL SINEX; Fiscal Year: 2008
    ....
  51. CORTICAL AND BEHAVIORAL RESPONSES TO COCHLEAR IMPLANTS
    John C Middlebrooks; Fiscal Year: 2010
    ..Aim 3 will identify changes in the central auditory pathway that result from deafness and chronic electrical stimulation and, thus, will inform decisions regarding age of implantation and patterns of chronic stimulation. ..
  52. Presbycusis: Biomedical Risk Factors
    GEORGE GATES; Fiscal Year: 2005
    ..abstract_text> ..
  53. DEVELOPMENT OF EFFERENT NERVE FIBERS IN THE COCHLEA
    HANNA SOBKOWICZ; Fiscal Year: 2001
    ..plans to identify ultrastructurally the morphological and immunochemical character of vesiculated endings that express GAP-43 in the inner spiral bundle, the only neuronal pathway that contains this growth protein in the adult cochlea. ..
  54. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2003
    ....
  55. Hearing in Belgian Waterslager Canaries
    AMANDA LAUER; Fiscal Year: 2004
    ..Thus, the proposed experiments will increase our understanding of the functional consequences of hearing impairment in these birds, and of hearing impairment in general. ..
  56. Genetics and Pediatric Nonsyndromic Hearing Loss
    Margaret Kenna; Fiscal Year: 2005
    ..This information will be used to evaluate the effectiveness of genetic counseling associated with gene testing for deafness. ..
  57. Amino Acid Transmitters in the Auditory Brainstem
    Richard Altschuler; Fiscal Year: 2006
    ..abstract_text> ..
  58. The Efficacy of Group Aural Rehabilitation Program
    JILL PREMINGER; Fiscal Year: 2005
    ..This data will be analyzed with the data from Experiment 1. The results of Experiment 2 will determine which aspect(s) of group aural rehabilitation classes provide benefit. ..
  59. STRESS RESPONSE PATHWAYS IN THE RODENT COCHLEA
    Richard Altschuler; Fiscal Year: 2004
    ..They will generate a rational mechanistic framework for future studies on interventions to reduce acquired deafness. ..
  60. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  61. COBRE IN SENSORY NEUROSCIENCE
    George Spirou; Fiscal Year: 2009
    ..To enhance and ?accelerate the pace of translational research projects among the clinical and basic science faculty at WVU. ..
  62. BIOCHEMICAL CONTROL OF EXCITABILITY IN NEURONS
    Leonard K Kaczmarek; Fiscal Year: 2010
    ..abstract_text> ..
  63. Auditory prostheses in realistic listening environments
    Ginger Stickney; Fiscal Year: 2003
    ..Envelope cues suffice for these S/N comparisons. However, fine structure will be necessary for localization tasks based on interaural time differences in bilateral implant simulations (Experiment 2b). ..
  64. Gene Transfer to the Inner Ear
    Anne Luebke; Fiscal Year: 2003
    ..Information gained from these studies will aid development of theraupeutic strategies targeted at genes involved in deafness. ..
  65. Inhibition in Binaural Processing
    George Spirou; Fiscal Year: 2006
    ..for hearing preservation following damage to the auditory system, such as through design or activation of cochlear nucleus prostheses, and for the design of speech recognition systems used in complex acoustic environments ..
  66. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2009
    ..We determined that the loss of CGRP in knockout mice reduced sound-evoked activity of the cochlear nerve, which would then cause a reduction in the dynamic range of sound perception...
  67. Effect of Noise Induced Hearing Loss on AVCN Principal Neurons
    Yong Wang; Fiscal Year: 2008
    ..abstract_text> ..
  68. Temporal Resolution of Cochlear and Auditory Nerve Responses in Older Adults
    Dawn Konrad Martin; Fiscal Year: 2008
    ..Therefore, this research has additional significance in that it may lead to development of clinical tools that will target sources of reduced temporal processing. [unreadable] [unreadable] [unreadable]..
  69. Development & Connections of Cochlear Spiral Ganglion
    Patricia Leake; Fiscal Year: 2007
    ..In addition, studies to be conducted in deafened animals have practical implications regarding application of cochlear implants in children. ..
  70. INTEGRATION OF INPUTS IN THE INFERIOR COLLICULUS
    Kevin Davis; Fiscal Year: 2006
    ..abstract_text> ..
  71. Molecular Basis of a Critical Period in Cochlear Nucleus
    Julie Harris; Fiscal Year: 2005
    ....
  72. BRAILLE READING & ADAPTIVE PLASTICITY IN THE HUMAN BRAIN
    Harold Burton; Fiscal Year: 2009
    ..In all experiments blood oxygen level dependent response dynamics in visual and selective non-visual areas will be quantitatively analyzed and correlated with performance to determine likely causal relationships. ..
  73. HEARING DEFICIT DUE TO AUDITORY NEUROPATHY
    Arnold Starr; Fiscal Year: 2009
    ..The results of our studies could have major impact on the diagnosis, classification, understanding, and treatment of auditory neuropathy. ..
  74. Optimized Conditioned Processing for Cochlear Implants
    Jay T Rubinstein; Fiscal Year: 2010
    ..In unilateral implantees, this work has already demonstrated substantial benefit in a limited number of subjects;it is our goal to deliver these benefits to the broader population of implant recipients. ..
  75. Assessing Auditory Capacity in Hearing-Impaired Children
    Laurie Eisenberg; Fiscal Year: 2007
    ..The results will be analyzed to explain and model auditory perceptual development in terms of multiple contributing variables and their interactions. ..