cochlear nerve

Summary

Summary: The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.

Top Publications

  1. ncbi Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function
    M Knipper
    University of Tubingen, Department of Oto Rhino Laryngology, Tübingen Centre for Hearing Research, Röntgenweg 11, D 72076 Tubingen, Germany
    Development 125:3709-18. 1998
  2. pmc Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss
    Sharon G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:14077-85. 2009
  3. pmc Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
    Wei Chen
    Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
    Nature 490:278-82. 2012
  4. pmc Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss
    Hainan Lang
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3541-50. 2006
  5. pmc Dynamic range adaptation to sound level statistics in the auditory nerve
    Bo Wen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Neurosci 29:13797-808. 2009
  6. ncbi Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans
    John J Guinan
    Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 27:589-607. 2006
  7. pmc Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons
    JENNIFER A CHIKAR
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109 5616, United States
    Hear Res 245:24-34. 2008
  8. ncbi Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve
    Zhengqing Hu
    Center for Hearing and Communication Research, and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1026:68-73. 2004
  9. pmc Envelope coding in auditory nerve fibers following noise-induced hearing loss
    Sushrut Kale
    Weldon School of Biomedical Engineering, Purdue University, 500 Oval Drive, West Lafayette, IN 47907, USA
    J Assoc Res Otolaryngol 11:657-73. 2010
  10. ncbi Auditory neuropathy characteristics in children with cochlear nerve deficiency
    Craig A Buchman
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ear Hear 27:399-408. 2006

Research Grants

  1. High resolution mapping of the Cochlear nerve using optical stimulation
    Jonathon Wells; Fiscal Year: 2007
  2. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2006
  3. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2006
  4. NEUROGENESIS IN THE AUDITORY SYSTEM
    DONALD MOREST; Fiscal Year: 2005
  5. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2004
  6. ELECTRON MICROSCOPY OF THE INNER EAR
    Robert Kimura; Fiscal Year: 1990
  7. MORPHOLOGY & CONNECTIONS OF THE SPIRAL GANGLION
    Patricia Leake; Fiscal Year: 1990
  8. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 2000
  9. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 1999
  10. CELL INTERACTIONS IN THE DEVELOPING AUDITORY SYSTEM
    Thomas Parks; Fiscal Year: 1992

Detail Information

Publications291 found, 100 shown here

  1. ncbi Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function
    M Knipper
    University of Tubingen, Department of Oto Rhino Laryngology, Tübingen Centre for Hearing Research, Röntgenweg 11, D 72076 Tubingen, Germany
    Development 125:3709-18. 1998
    ..The thyroid hormone-dependent commencement of nerve conduction is discussed in connection with the patterning refinement of central auditory pathways and the acquisition of deafness...
  2. pmc Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss
    Sharon G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:14077-85. 2009
    ..sensory cells intact, but cause acute loss of afferent nerve terminals and delayed degeneration of the cochlear nerve. Results suggest that noise-induced damage to the ear has progressive consequences that are considerably more ..
  3. pmc Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
    Wei Chen
    Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
    Nature 490:278-82. 2012
    ..These results should stimulate further research into the development of a cell-based therapy for deafness...
  4. pmc Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss
    Hainan Lang
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3541-50. 2006
    ..A possible mechanism underlying this protection is that the NFkappaB activity may help to maintain calcium homeostasis in SGNs...
  5. pmc Dynamic range adaptation to sound level statistics in the auditory nerve
    Bo Wen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Neurosci 29:13797-808. 2009
    ..These findings suggest that adaptive processing of sound levels first occurs in the auditory periphery and is enhanced along the auditory pathway...
  6. ncbi Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans
    John J Guinan
    Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 27:589-607. 2006
    ..Monitoring MOC effects in humans using OAEs should continue to provide valuable insights into the role of MOC efferents and may also provide clinical benefits...
  7. pmc Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons
    JENNIFER A CHIKAR
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109 5616, United States
    Hear Res 245:24-34. 2008
    ..These results indicate that the changes in the anatomy of the auditory nerve induced by the combination of Ad.BDNF inoculation and the electrical stimulation used for testing improved functional measures of CI performance...
  8. ncbi Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve
    Zhengqing Hu
    Center for Hearing and Communication Research, and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1026:68-73. 2004
    ..The results demonstrate not only the survival and migration of xenografted DRG neurons and stem cells along the adult auditory nerve but also the feasibility of a cell replacement therapy in the degenerated auditory system...
  9. pmc Envelope coding in auditory nerve fibers following noise-induced hearing loss
    Sushrut Kale
    Weldon School of Biomedical Engineering, Purdue University, 500 Oval Drive, West Lafayette, IN 47907, USA
    J Assoc Res Otolaryngol 11:657-73. 2010
    ..Overall, these data suggest the need to consider the relative effects of SNHL on envelope and fine-structure coding in evaluating perceptual deficits in temporal processing of complex stimuli...
  10. ncbi Auditory neuropathy characteristics in children with cochlear nerve deficiency
    Craig A Buchman
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ear Hear 27:399-408. 2006
    To describe a group of children exhibiting electrophysiologic responses characteristic of auditory neuropathy (AN) who were subsequently identified as having absent or small cochlear nerves (i.e., cochlear nerve deficiency).
  11. pmc Response patterns to sound associated with labeled globular/bushy cells in cat
    W S Rhode
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Neuroscience 154:87-98. 2008
    ..5-2 ms notch after the initial spike, to an onset pattern with a low-sustained rate. They can represent low frequency tones and amplitude modulated signals exceptionally well with a temporal code...
  12. ncbi Outcomes in nontumor adults fitted with the auditory brainstem implant: 10 years' experience
    Vittorio Colletti
    ENT Department, University of Verona, Verona, Italy
    Otol Neurotol 30:614-8. 2009
    ..This study presents results from up to 10 years in adults, with analysis based on cause...
  13. pmc A phenomenological model of peripheral and central neural responses to amplitude-modulated tones
    Paul C Nelson
    Department of Bioengineering and Neuroscience and Institute for Sensory Research, Syracuse University, Syracuse, New York 13244, USA
    J Acoust Soc Am 116:2173-86. 2004
    ....
  14. ncbi Human frequency-following response: representation of pitch contours in Chinese tones
    Ananthanarayan Krishnan
    Auditory Electrophysiology Laboratory, Department of Audiology and Speech Sciences, Purdue University, West Lafayette, IN 47907 2038, USA
    Hear Res 189:1-12. 2004
    ..These FFR findings support the viability of early, population-based 'predominant interval' representations of pitch in the auditory brainstem that are based on temporal patterns of phase-locked neural activity...
  15. pmc Cochlear efferent feedback balances interaural sensitivity
    Keith N Darrow
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, Massachusetts 02114, USA
    Nat Neurosci 9:1474-6. 2006
    ..Thus, lateral olivocochlear feedback maintains the binaural balance in neural excitability required for accurate localization of sounds in space...
  16. ncbi Spontaneous activity of auditory-nerve fibers: insights into stochastic processes at ribbon synapses
    Peter Heil
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    J Neurosci 27:8457-74. 2007
    ..Our findings also constitute an essential step toward a better understanding of the spike-train representation of time-varying stimuli initiated at this synapse, and thus of the fundamentals of temporal coding in the auditory pathway...
  17. pmc Phase-locked responses to tones of chinchilla auditory nerve fibers: implications for apical cochlear mechanics
    Andrei N Temchin
    Hugh Knowles Center Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Assoc Res Otolaryngol 11:297-318. 2010
    ....
  18. pmc Binaural and cochlear disparities
    Philip X Joris
    Laboratory of Auditory Neurophysiology, University of Leuven, Campus Gasthuisberg, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 103:12917-22. 2006
    ..These findings suggest that cochlear disparities make an important contribution to the internal delays observed in binaural neurons...
  19. ncbi Temporal processing from the auditory nerve to the medial nucleus of the trapezoid body in the rat
    A G Paolini
    Department of Otolarynology, The University of Melbourne, Royal Victoria Eye and Ear Hospital, East Melbourne, Australia
    Hear Res 159:101-16. 2001
    ..Our results suggest that AVCN PL(N) units, representing globular bushy cells, are specialised for enhancing the temporal code at low frequencies and relaying this information to principal cells of the MNTB...
  20. pmc Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies
    Jeannie H Reyes
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci 28:12622-31. 2008
    ..This is the first study to report a high percentage of ES cell differentiation into a glutamatergic phenotype and sets the stage for cell replacement of auditory nerve...
  21. pmc Wiener kernels of chinchilla auditory-nerve fibers: verification using responses to tones, clicks, and noise and comparison with basilar-membrane vibrations
    Andrei N Temchin
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Neurophysiol 93:3635-48. 2005
    ....
  22. ncbi Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion
    Helge Rask-Andersen
    Department of Otosurgery, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Hear Res 203:180-91. 2005
    ..Transplantation of progenitor cells together with established means to induce neural differentiation and fiber growth may facilitate strategies for better repair and treatment of auditory neuronal damage...
  23. ncbi Firing patterns of type II spiral ganglion neurons in vitro
    Michael A Reid
    Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08854 8082, USA
    J Neurosci 24:733-42. 2004
    ..In particular, the type II neuron properties are consistent with cells in other sensory systems that receive convergent synaptic input for high-sensitivity stimulus detection...
  24. ncbi Imaging findings of cochlear nerve deficiency
    Christine M Glastonbury
    Department of Radiology, University Hospital, Salt Lake City, UT, USA
    AJNR Am J Neuroradiol 23:635-43. 2002
    ..Absence or reduction in caliber of the cochlear nerve (deficiency) has been described in association with congenital sensorineural hearing loss (SNHL)...
  25. ncbi Human frequency-following responses: representation of steady-state synthetic vowels
    Ananthanarayan Krishnan
    Auditory Electrophysiology Laboratory, Department of Audiology and Speech Sciences, Purdue University, W Lafayette, IN 47907, USA
    Hear Res 166:192-201. 2002
    ....
  26. ncbi Transplantation of conditionally immortal auditory neuroblasts to the auditory nerve
    Tetsuji Sekiya
    Department of Otolaryngology, Kyoto University Graduate School of Medicine, Sakyou ku, Kyoto, 606 8507 Japan
    Eur J Neurosci 25:2307-18. 2007
    ....
  27. ncbi Panoramic measurements of the apex of the cochlea
    Marcel van der Heijden
    Laboratory of Auditory Neurophysiology, K U Leuven Medical School, B 3000 Leuven, Belgium
    J Neurosci 26:11462-73. 2006
    ....
  28. pmc Stem cell transplantation for auditory nerve replacement
    Richard A Altschuler
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150W Medical Center Drive, Ann Arbor, MI 48109 5616, United States
    Hear Res 242:110-6. 2008
    ....
  29. pmc Temporal response properties of the auditory nerve: data from human cochlear-implant recipients
    Michelle L Hughes
    Boys Town National Research Hospital, Lied Learning and Technology Center, 425 North 30th Street, Omaha, NE 68131, USA
    Hear Res 285:46-57. 2012
    ..Differences in temporal response properties across the cochlea within subjects may have implications for developing new speech-processing strategies that employ varied rates across the array...
  30. pmc Fast negative feedback enables mammalian auditory nerve fibers to encode a wide dynamic range of sound intensities
    Mark Ospeck
    PLoS ONE 7:e32384. 2012
    ..The ANF spike generator remains very sensitive to threshold currents, but efferent feedback is able to lower its gain in response to noise...
  31. ncbi Effect of topically applied basic fibroblast growth factor on injured cochlear nerve
    Tetsuji Sekiya
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosurgery 52:900-7; discussion 907. 2003
    ..To challenge such a pessimistic view, we investigated whether pharmacological interventions with basic fibroblast growth factor (bFGF) could ameliorate trauma-induced cochlear nerve degeneration.
  32. pmc Effect of auditory-nerve response variability on estimates of tuning curves
    Ananthakrishna Chintanpalli
    Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive, West Lafayette, Indiana 47907, USA
    J Acoust Soc Am 122:EL203-9. 2007
    ..Errors in estimates of CF, which decreased from +/-0.2 octaves at low frequencies to +/-0.05 octaves at high frequencies, are significant for studies of spatiotemporal coding...
  33. doi The convergence of cochlear implantation with induced pluripotent stem cell therapy
    Niliksha Gunewardene
    Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia
    Stem Cell Rev 8:741-54. 2012
    ....
  34. doi Cochlear implantation in children with labyrinthine anomalies and cochlear nerve deficiency: implications for auditory brainstem implantation
    Craig A Buchman
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Laryngoscope 121:1979-88. 2011
    Compare outcomes among children with inner ear malformations and/or cochlear nerve deficiency (CND) who have received a cochlear implant (CI).
  35. ncbi Relationship between the auditory brainstem response and auditory nerve thresholds in cats with hearing loss
    E M Ngan
    Department of Otolaryngology-HNS, Johns Hopkins University, 505 Traylor Research Building, 720 Rutland Avenue, Baltimore, MD 21205-2195, USA
    Hear Res 156:44-52. 2001
    ..Across varying degrees of hearing loss, the ABR maintained a systematic relationship to auditory nerve fiber thresholds, and therefore has the potential to be used as a functional assay of cochlear pathology...
  36. doi Forward masking as a method of measuring place specificity of neural excitation in cochlear implants: a review of methods and interpretation
    Colette M McKay
    School of Psychological Sciences, University of Manchester, Oxford Road, Manchester, M33 3GH, United Kingdom
    J Acoust Soc Am 131:2209-24. 2012
    ..The effects of unit of measurement on specificity measures and the effects of subject listening strategy on the forward masked functions are also discussed...
  37. doi Transmission of phase-coupling accuracy from the auditory nerve to spherical bushy cells in the Mongolian gerbil
    Susanne Dehmel
    Faculty of Biosciences, University of Leipzig, Talstrasse 33, 04103 Leipzig, Germany
    Hear Res 268:234-49. 2010
    ..These results suggest that the phase-coupling accuracy is improved in a subpopulation of SBCs during transmission from the auditory nerve to the SBCs by reduction of spike rates...
  38. pmc Auditory brainstem responses predict auditory nerve fiber thresholds and frequency selectivity in hearing impaired chinchillas
    Kenneth S Henry
    Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN 47907, USA
    Hear Res 280:236-44. 2011
    ..Furthermore, comparisons of ABR wave I latency to normative data at the same SL may prove useful for detecting and characterizing loss of cochlear frequency selectivity...
  39. ncbi Variable long-term outcomes from cochlear implantation in children with hypoplastic auditory nerves
    Jane Bradley
    Royal National Throat Nose and Ear Hospital, London WC1X 8DA, UK
    Cochlear Implants Int 9:34-60. 2008
    ..In specific cases it may be appropriate to offer a cochlear implant to a child with hypoplastic auditory nerves but careful counselling of the family about likely outcomes is essential...
  40. pmc Enhanced auditory neuron survival following cell-based BDNF treatment in the deaf guinea pig
    Lisa N Pettingill
    The Bionic Ear Institute, East Melbourne, Victoria, Australia
    PLoS ONE 6:e18733. 2011
    ....
  41. ncbi A model for implanting neuronal tissue into the cochlea
    Petri Olivius
    Department of Clinical Neuroscience, Section of Otorhinolaryngology, Center for Hearing and Communication Research, Karolinska Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Brain Res Brain Res Protoc 12:152-6. 2004
    ....
  42. doi Vascular compression of the cochlear nerve and tinnitus: a pathophysiological investigation
    Dirk De Ridder
    TRI Tinnitus Clinic, BRAI2N and Department of Neurosurgery, University Hospital Antwerp, Edegem, Belgium
    Acta Neurochir (Wien) 154:807-13. 2012
    ..Chronic microvascular compressions of the eighth nerve induce a slowing down of signal transmission in the auditory nerve, electrophysiologically characterized by IPL I-III prolongation...
  43. doi Variations in carrier pulse rate and the perception of amplitude modulation in cochlear implant users
    Tim Green
    University College London, Speech Hearing and Phonetic Sciences, London, United Kingdom
    Ear Hear 33:221-30. 2012
    ....
  44. ncbi A cell therapy approach to substitute neural elements in the inner ear
    Mats Ulfendahl
    Karolinska Institutet, Center for Hearing and Communication Research, Department of Otolaryngology, Karolinska University Hospital, S 177 76 Stockholm, Sweden
    Physiol Behav 92:75-9. 2007
    ..In addition, it is possible that the physical properties of the cochlea, e.g., fluid-filled compartments and very limited space for cell proliferation, are unfavorable, at least in the normal cochlea...
  45. pmc Disruption of lateral efferent pathways: functional changes in auditory evoked responses
    Colleen G Le Prell
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109 0506, USA
    J Assoc Res Otolaryngol 4:276-90. 2003
    ..They also confirm the suggestion that changes in single-unit auditory nerve activity after cutting the olivocochlear bundle are probably a consequence of disrupting the more lateral of the two olivocochlear efferent pathways...
  46. ncbi Are cochlear implant patients suffering from perceptual dissonance?
    Gerald E Loeb
    Department of Biomedical Engineering, Viterbi School of Engineering and A E Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles 90089 1112, USA
    Ear Hear 26:435-50. 2005
    ....
  47. pmc Site of cochlear stimulation and its effect on electrically evoked compound action potentials using the MED-EL standard electrode array
    Stefan Brill
    Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Wurzburg, Germany
    Biomed Eng Online 8:40. 2009
    ..The aim of this study is to determine if certain properties of ECAP recordings vary, depending on the stimulation site in the cochlea...
  48. ncbi Physiological effects of auditory nerve myelinopathy in chinchillas
    Mohamed M El-Badry
    Otolaryngology Department, Audiology Unit, El Minia University Hospitals, El Minia University, El Minia, Egypt
    Eur J Neurosci 25:1437-46. 2007
    ..The results support auditory nerve myelinopathy as a possible pathomechanism of auditory neuropathy but indicate that myelinopathy must be severe before physiological measures are affected...
  49. pmc Chronic reduction of endocochlear potential reduces auditory nerve activity: further confirmation of an animal model of metabolic presbyacusis
    Hainan Lang
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Charleston, SC 29425, USA
    J Assoc Res Otolaryngol 11:419-34. 2010
    ..These results suggest that dysfunction of the cochlear lateral wall and subsequent chronic reduction in the EP can directly affect the activity patterns of primary auditory neurons in a manner similar to that seen in aged gerbils...
  50. pmc Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans
    Fred H Linthicum
    House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 30:418-422. 2009
    ..To demonstrate that contrary to what occurs in animals, neuron loss in the human spiral ganglion is not in proportion to organ of Corti hair or supporting cell loss...
  51. pmc Response characteristics in the apex of the gerbil cochlea studied through auditory nerve recordings
    Corstiaen P C Versteegh
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    J Assoc Res Otolaryngol 12:301-16. 2011
    ..Overall, our data suggest that mechanical responses in the apex of the cochlea are considerably nonlinear and that these nonlinearities are of a different character than those known from the base of the cochlea...
  52. ncbi Internal auditory canal morphology in children with cochlear nerve deficiency
    Oliver F Adunka
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7600, USA
    Otol Neurotol 27:793-801. 2006
    To describe the internal auditory canal (IAC) and inner ear morphologic characteristics of children with cochlear nerve (CN) deficiency.
  53. ncbi The clinical application of potentials evoked from the peripheral auditory system
    Charles A Miller
    Department of Otolaryngology, University of Iowa, United States
    Hear Res 242:184-97. 2008
    ..Future research directions, which will likely involve the integration of various dimensions of the electrically evoked response that have been studied in isolation, are also suggested...
  54. ncbi Aplasia of the cochlear nerve: a temporal bone study
    E G Nelson
    Section of Otolaryngology-Head and Neck Surgery, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 1035, Chicago, IL 60637, USA
    Otol Neurotol 22:790-5. 2001
    OBJECTIVE: The purpose of this study was to evaluate the temporal bone findings in individuals with cochlear nerve aplasia. STUDY DESIGN: Retrospective case review...
  55. ncbi Comparison of bandwidths in the inferior colliculus and the auditory nerve. I. Measurement using a spectrally manipulated stimulus
    Myles Mc Laughlin
    Laboratory of Auditory Neurophysiology, Medical School, Campus Gasthuisberg, Leuven, Belgium
    J Neurophysiol 98:2566-79. 2007
    ..We find that both AN and IC filter BW depend on characteristic frequency, but that there is no difference in mean BW between the AN and IC...
  56. pmc Threshold tuning curves of chinchilla auditory-nerve fibers. I. Dependence on characteristic frequency and relation to the magnitudes of cochlear vibrations
    Andrei N Temchin
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Neurophysiol 100:2889-98. 2008
    ..At the apex of the chinchilla cochlea, frequency tuning is substantially sharper for ANFs than for available recordings of organ of Corti vibrations...
  57. pmc Variation in the phase of response to low-frequency pure tones in the guinea pig auditory nerve as functions of stimulus level and frequency
    Alan R Palmer
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
    J Assoc Res Otolaryngol 10:233-50. 2009
    ..This null frequency was often not at the CF. At stimulation frequencies below the null, there was a progressive lag with sound level and a progressive lead for stimulation frequencies above the null. This was maximally 0.2 cycles...
  58. ncbi Preliminary results of auditory brainstem implantation in prelingually deaf children with inner ear malformations including severe stenosis of the cochlear aperture and aplasia of the cochlear nerve
    Levent Sennaroglu
    Department of Otolaryngology, Hacettepe University Medical Faculty, Ankara, Turkey
    Otol Neurotol 30:708-15. 2009
    ..The aim of our study is to present the results of 11 children where auditory brainstem implantation (ABI) was successfully performed to restore hearing...
  59. pmc In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response
    Sanjiv B Amin
    Department of Pediatrics, Division of Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Pediatr 156:377-81. 2010
    ..To determine whether cord ferritin (CF) concentration, an index of in utero iron status, is associated with auditory neural maturation in premature infants...
  60. pmc Threshold tuning curves of chinchilla auditory nerve fibers. II. Dependence on spontaneous activity and relation to cochlear nonlinearity
    Andrei N Temchin
    Dept of Communication Sciences and Disorders, Northwestern Univ, 2240 Campus Dr, Evanston, IL 60208 3550, USA
    J Neurophysiol 100:2899-906. 2008
    ..It is shown here that this dependence of tuning on spontaneous rates is consistent with a previously unnoticed nonmonotonic dependence on iso-velocity criterion of the frequency tuning of basilar membrane vibrations...
  61. ncbi Functional correlates of characteristic frequency in single cochlear nerve fibers of the Mongolian gerbil
    K K Ohlemiller
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208
    J Comp Physiol A 167:329-38. 1990
    ..thresholds encountered, even when data from many animals were combined, rarely exceeded 20 dB, suggesting that cochlear nerve responses obtained from this species display little inter-animal variability...
  62. pmc Correct tonotopic representation is necessary for complex pitch perception
    Andrew J Oxenham
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:1421-5. 2004
    ..The experiments demonstrate that tonotopic representation is crucial to complex pitch perception and provide a new tool in the search for the neural basis of pitch...
  63. ncbi Interaural time sensitivity dominated by cochlea-induced envelope patterns
    Philip X Joris
    Laboratory of Auditory Neurophysiology, Medical School, Campus Gasthuisberg, K U Leuven, B 3000 Leuven, Belgium
    J Neurosci 23:6345-50. 2003
    ..These results suggest that internally generated envelopes play a more important role in binaural hearing than is commonly thought...
  64. pmc Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 25:6857-68. 2005
    ..6 and Nav1.2 in the cochlear ganglion, cochlear nerve, and organ of Corti, including the type I and type II ganglion cells. In most type I ganglion cells, Nav1...
  65. ncbi Temporal properties of responses to broadband noise in the auditory nerve
    Dries H G Louage
    Laboratory of Auditory Neurophysiology, Medical School, K U Leuven, B 3000 Leuven, Belgium
    J Neurophysiol 91:2051-65. 2004
    ..We conclude that the combined use of broadband noise and SAC analysis allow a more general characterization of temporal behavior than periodic stimuli and Fourier analysis...
  66. doi Neural encoding in the human brainstem relevant to the pitch of complex tones
    Ananthanarayan Krishnan
    Department of Speech Language Hearing Sciences, Purdue University, 1353 Heavilon Hall, 500 Oval Drive, West Lafayette, IN 47907 2038, USA
    Hear Res 275:110-9. 2011
    ..The scalp recorded FFR may provide for a non-invasive analytic tool to evaluate neural encoding of complex sounds in humans...
  67. ncbi Cochlear nerve demyelination causes prolongation of wave I latency in ABR of the myelin deficient (md) rat
    Tetsufumi Ito
    Department of Anatomy, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Hear Res 191:119-24. 2004
    ..ABRs showed a marked prolongation not only wave II-IV latencies but also wave I latency. Cochlear nerve fibers near the modiolus lost their myelin halfway into the internal auditory canal...
  68. ncbi Brainstem auditory-evoked potentials in iron-deficiency anemia
    S U Sarici
    Department of Pediatrics, , Ankara, Turkey
    Pediatr Neurol 24:205-8. 2001
    ..Although we could not demonstrate a hearing loss in infants with moderate iron-deficiency anemia in this study, the relationship between severe iron-deficiency anemia and hearing loss or auditory dysfunction remains to be determined...
  69. doi Unique expression of connexins in the human cochlea
    Wei Liu
    Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden
    Hear Res 250:55-62. 2009
    ..Their potential role in the processing of human auditory nerve signaling as well as non-GJ roles of the connexins in human cochlea is discussed...
  70. ncbi Delivery of neurotrophin-3 to the cochlea using alginate beads
    Farnoosh Noushi
    University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
    Otol Neurotol 26:528-33. 2005
    ..The aim of this study was to design a novel cochlear neurotrophin (NT) delivery system for the rescue of auditory neurons after ototoxicity-induced deafening...
  71. doi Apparent cochlear nerve aplasia: to implant or not to implant?
    Frank M Warren
    Division of Otolaryngology, Head and Neck Surgery, University of Utah, Salt Lake City, Utah 84132, U S A
    Otol Neurotol 31:1088-94. 2010
    To describe the imaging findings and clinical outcomes of children with apparent cochlear nerve aplasia undergoing cochlear implantation.
  72. pmc The volley theory and the spherical cell puzzle
    P X Joris
    Laboratory of Auditory Neurophysiology, K U Leuven, Campus GHB O and N2, Herestraat 49 bus 1021, B 3000 Leuven, Belgium
    Neuroscience 154:65-76. 2008
    ....
  73. ncbi Functional anatomy of the human cochlear nerve and its role in microvascular decompressions for tinnitus
    Dirk De Ridder
    Department of Neurosurgery and Otorhinolaryngology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium
    Neurosurgery 54:381-8; discussion 388-90. 2004
    The functional anatomy (i.e., tonotopy) of the human cochlear nerve is unknown...
  74. doi Comparison of bandwidths in the inferior colliculus and the auditory nerve. II: Measurement using a temporally manipulated stimulus
    Myles Mc Laughlin
    Laboratory of Auditory Neurophysiology, Medical School, K U Leuven, Campus Gasthuisberg O and N 2, Herestraat 49 bus 1021, B 3000 Leuven, Belgium
    J Neurophysiol 100:2312-27. 2008
    ..We conclude that binaural sensitivity is more dependent on correlation sensitivity than has hitherto been appreciated and that the mechanisms underlying correlation sensitivity should be addressed in future studies...
  75. ncbi Microvascular decompression of cochlear nerve for tinnitus incapacity: pre-surgical data, surgical analyses and long-term follow-up of 15 patients
    Nicolas Guevara
    Department of Otorhinolaryngology, CHU de Nice, Hopital Pasteur, 30, avenue de la Voie Romaine, B P 69, 06002 Nice, Cedex 1, France
    Eur Arch Otorhinolaryngol 265:397-401. 2008
    ..However, cochlear nerve compression syndrome by vascular loop is still a controversial topic...
  76. pmc Subthreshold K+ channel dynamics interact with stimulus spectrum to influence temporal coding in an auditory brain stem model
    Mitchell L Day
    Center for Neural Science, New York University, New York, NY, USA
    J Neurophysiol 99:534-44. 2008
    ....
  77. ncbi A model of the electrically excited human cochlear neuron. I. Contribution of neural substructures to the generation and propagation of spikes
    F Rattay
    TU BioMed, Vienna University of Technology, Austria
    Hear Res 153:43-63. 2001
    ..Comparing the reactions of a human and cat cochlear neuron, we find differences in spiking behavior, e.g. peripherally and centrally evoked spikes arrive with a time difference of about 400 mus in man and 200 mus in cat...
  78. pmc Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapse
    Lisa Grant
    The Johns Hopkins School of Medicine, Department of Otolaryngology Head and Neck Surgery, Baltimore, Maryland 21205, USA
    J Neurosci 30:4210-20. 2010
    ..We propose that the relative contribution of two modes of multivesicular release, generating monophasic and multiphasic EPSCs, may underlie fundamental characteristics of auditory nerve fibers...
  79. ncbi A simple two-component model of the electrically evoked compound action potential in the human cochlea
    W K Lai
    ENT Department, University Hospital, Zurich, Switzerland
    Audiol Neurootol 5:333-45. 2000
    ..This information could be useful for determining optimal speech coding parameters for cochlear implant users on an individual basis...
  80. ncbi A model of a nucleus 24 cochlear implant fitting protocol based on the electrically evoked whole nerve action potential
    Kevin H Franck
    Center for Childhood Communication, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Ear Hear 23:67S-71S. 2002
    ....
  81. pmc Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 3096, USA
    J Assoc Res Otolaryngol 10:50-63. 2009
    ..Our results suggest that GABAergic signaling in type II afferent neurons may be required for normal outer hair cell amplifier function at low sound levels and may also modulate outer hair cell responses to high-level sound...
  82. pmc Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti
    C Eduardo Corrales
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Neurobiol 66:1489-500. 2006
    ..degeneration, we injected EYFP-expressing embryonic stem cell-derived mouse neural progenitor cells into the cochlear nerve trunk in immunosuppressed animals 1 week after destroying the cochlear nerve (spiral ganglion) cells while ..
  83. ncbi Electrical stimulation of the cochlear nerve in rats: analysis of c-Fos expression in auditory brainstem nuclei
    Makoto Nakamura
    Department of Neurosurgery, Klinikum Hannover Nordstadt, Hannover, Germany
    Brain Res 1031:39-55. 2005
    ..functional activation of central auditory brainstem nuclei in response to direct electrical stimulation of the cochlear nerve using c-Fos immunoreactivity as a marker for functional mapping...
  84. ncbi Effect of deep insertion of the cochlear implant electrode array on pitch estimation and speech perception
    Jafar Hamzavi
    Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria
    Acta Otolaryngol 126:1182-7. 2006
    ..Deeply inserted electrodes offer the possibility that apical stimulation may improve speech performances. Therefore, deep insertion is reasonable and should be performed in patients with profound or total hearing loss...
  85. ncbi Rate and timing cues associated with the cochlear amplifier: level discrimination based on monaural cross-frequency coincidence detection
    M G Heinz
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Acoust Soc Am 110:2065-84. 2001
    ..Monaural coincidence detection is a physiologically realistic mechanism that is extremely general in that it can utilize AN information (average-rate, synchrony, and nonlinear-phase cues) from all SR groups...
  86. ncbi Intracochlear and extracochlear ECAPs suggest antidromic action potentials
    Charles A Miller
    Department of Otolaryngology, Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21201 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Hear Res 198:75-86. 2004
    ..Compared with the feline ECAPs, the human potentials had smaller amplitudes and longer latencies. It is not clear what underlies these differences, although several factors are considered...
  87. pmc Response properties of the refractory auditory nerve fiber
    C A Miller
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City 52242, USA
    J Assoc Res Otolaryngol 2:216-32. 2001
    ..Relative spread was found to increase with decreasing MPI values, providing direct evidence that stochastic properties of fibers are altered under conditions of refractoriness...
  88. ncbi Ensemble spontaneous activity in the guinea-pig cochlear nerve
    G D Searchfield
    Discipline of Audiology and Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, New Zealand
    Hear Res 192:23-35. 2004
    ..from the round window (RW) of the cochlea is referred to as the ensemble spontaneous activity (ESA) of the cochlear nerve. The ESA is considered to represent the summed spontaneous activity of single fibers of the auditory nerve and ..
  89. ncbi Measuring the refractoriness of the electrically stimulated auditory nerve
    Andre Morsnowski
    Cochlear Implant Centrum Schleswig Kiel, Department of Oto Rhino Laryngology, Head and Neck Surgery, Christian Albrechts University of Kiel, Kiel, Germany
    Audiol Neurootol 11:389-402. 2006
    ..This can bias the measurement of ECAP thresholds. Additionally, the shape of standard forward masking recovery functions was explained by the influence of latency shift of the neural response...
  90. ncbi 3-T imaging of the cochlear nerve and labyrinth in cochlear-implant candidates: 3D fast recovery fast spin-echo versus 3D constructive interference in the steady state techniques
    John I Lane
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    AJNR Am J Neuroradiol 25:618-22. 2004
    ..5 T is often performed by using three-dimensional (3D) fast spin-echo or T2* techniques. We evaluated both techniques at 3 T in the preoperative assessment of patients being considered for cochlear implants...
  91. ncbi A model of the electrically excited human cochlear neuron. II. Influence of the three-dimensional cochlear structure on neural excitability
    F Rattay
    TU BioMed, Vienna University of Technology, Austria
    Hear Res 153:64-79. 2001
    ..2001] allows for simulation of the excitation process of selected elements of the cochlear nerve. The bony boundary has an insulating influence along every nerve fiber which shifts the stimulation condition ..
  92. pmc Effect of interphase gap and pulse duration on electrically evoked potentials is correlated with auditory nerve survival
    Pavel Prado-Guitierrez
    Department of Otolaryngology, The University of Melbourne, Australia
    Hear Res 215:47-55. 2006
    ..These results may provide a tool for investigating the contribution of auditory nerve survival to clinical performance among cochlear implant subjects...
  93. ncbi Adaptation in a revised inner-hair cell model
    Christian J Sumner
    Centre for the Neural Basis of Hearing at Essex, Department of Psychology, University of Essex, Colchester CO4 3SQ, United Kingdom
    J Acoust Soc Am 113:893-901. 2003
    ..A HSR model fiber performs similarly to the earlier version of the model. However, there is considerable variation in response to increments and decrements between different model fibers...
  94. ncbi Delayed neurotrophic treatment preserves nerve survival and electrophysiological responsiveness in neomycin-deafened guinea pigs
    Takahiko Yamagata
    Center for Hearing and Communication Research and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 78:75-86. 2004
    ..It is noteworthy that this same degree of ganglion cell loss, secondary to receptor damage, is typically observed after a period equivalent to some years of deafness in humans...
  95. ncbi C-Fos immunoreactivity mapping of the auditory system after electrical stimulation of the cochlear nerve in rats
    Makoto Nakamura
    Department of Neurosurgery, Nordstadt Hospital, Haltenhoffstr 41, 30167 Hannover, Germany
    Hear Res 184:75-81. 2003
    ..as a marker for functional mapping in the auditory system in response to direct electrical stimulation of the cochlear nerve in the cerebellopontine angle...
  96. pmc Mathematical models of cochlear nucleus onset neurons: I. Point neuron with many weak synaptic inputs
    Sridhar Kalluri
    Harvard University Massachusetts Institute of Technology, Division of Health Sciences and Technology, Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Comput Neurosci 14:71-90. 2003
    ..These results show a tradeoff, that may be a general property of many neurons, between following rapid stimulus fluctuations and responding without short interspike intervals at the onset of sustained stimuli...
  97. ncbi Tuning and timing in the gerbil ear: Wiener-kernel analysis
    Edwin R Lewis
    Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA
    Hear Res 174:206-21. 2002
    ..Eigen or singular-value decomposition of the second-order Wiener kernel allows us to separate excitatory and suppressive effects, and to determine precisely the timing of the latter...
  98. ncbi A phenomenological model for the responses of auditory-nerve fibers. II. Nonlinear tuning with a frequency glide
    Qing Tan
    Boston University Hearing Research Center, Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    J Acoust Soc Am 114:2007-20. 2003
    ..The ability of this model to process arbitrary sound inputs makes it a useful tool for studying peripheral auditory processing...
  99. pmc Mathematical models of cochlear nucleus onset neurons: II. model with dynamic spike-blocking state
    Sridhar Kalluri
    Harvard University Massachusetts Institute of Technology, Division of Health Sciences and Technology, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Comput Neurosci 14:91-110. 2003
    ..These results provide a mechanistic rationale for distinguishing between the different physiological classes of CN On neurons...
  100. ncbi A revised model of the inner-hair cell and auditory-nerve complex
    Christian J Sumner
    Centre for the Neural Basis of Hearing at Essex, Department of Psychology, University of Essex, Colchester, United Kingdom
    J Acoust Soc Am 111:2178-88. 2002
    ..The model also reproduces quantitatively phase-locking characteristics, relative refractory effects, mean-to-variance ratio, and first- and second-order discharge history effects...
  101. ncbi A nonlinear filter-bank model of the guinea-pig cochlear nerve: rate responses
    Christian J Sumner
    Centre for the Neural Basis of Hearing at Essex, Department of Psychology, University of Essex, Colchester CO4 3SQ, United Kingdom
    J Acoust Soc Am 113:3264-74. 2003
    ..The model is a convenient computational tool for the simulation of the range of nonlinear tuning and rate-responses found across the length of the guinea-pig cochlear nerve.

Research Grants73

  1. High resolution mapping of the Cochlear nerve using optical stimulation
    Jonathon Wells; Fiscal Year: 2007
    ..This research will focus on enhancing the performance of the cochlear implant to allow people to hear speech in a crowded room. [unreadable] [unreadable] [unreadable]..
  2. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2006
    ..Phenotypic analysis revealed a hearing disorder associated with post-natal, primary degeneration of cochlear nerve fibers (without hair cell loss) and a balance disorder associated with a reduction in the size of the ..
  3. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2006
    ..The net effect of these hair cell actions is the production of discharge activity in the cochlear nerve. Tools are now available to dissect the processes in each of these cellular compartments and examine their ..
  4. NEUROGENESIS IN THE AUDITORY SYSTEM
    DONALD MOREST; Fiscal Year: 2005
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as major incurable disorders today...
  5. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2004
    ..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
  6. ELECTRON MICROSCOPY OF THE INNER EAR
    Robert Kimura; Fiscal Year: 1990
    ..and cell organelles using serial sections for electron microscopy; 2) to conduct morphological studies on the cochlear nerve fibers by studying serial sections, and autonomic nerve fibers by injection of horseradish peroxidase and ..
  7. MORPHOLOGY & CONNECTIONS OF THE SPIRAL GANGLION
    Patricia Leake; Fiscal Year: 1990
    ..cochleas are of clinical significance, as they further define: 1) factor(s) that induce degeneration of the cochlear nerve; and 2) the nature of the CN projections from ganglion cells surviving severe deafness pathology...
  8. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 2000
    ..Cochlear implants have been remarkably successful in restoring hearing to deaf patients with residual cochlear nerve function...
  9. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 1999
    ..Cochlear implants have been remarkably successful in restoring hearing to deaf patients with residual cochlear nerve function...
  10. CELL INTERACTIONS IN THE DEVELOPING AUDITORY SYSTEM
    Thomas Parks; Fiscal Year: 1992
    ..Early destruction of the otocyst (embryonic precursor of the inner ear and cochlear nerve) induces formation of an anomalous functional axonal projection connecting the cochlear nuclei on the two ..
  11. CELL INTERACTIONS IN THE DEVELOPING AUDITORY SYSTEM
    Thomas Parks; Fiscal Year: 1991
    ..Early destruction of the otocyst (embryonic precursor of the inner ear and cochlear nerve) induces formation of an anomalous functional axonal projection connecting the cochlear nuclei on the two ..
  12. CELL INTERACTIONS IN THE DEVELOPING AUDITORY SYSTEM
    Thomas Parks; Fiscal Year: 1990
    ..Early destruction of the otocyst (embryonic precursor of the inner ear and cochlear nerve) induces formation of an anomalous functional axonal projection connecting the cochlear nuclei on the two ..
  13. MORPHOLOGY AND CONNECTIONS OF THE SPIRAL GANGLION
    Patricia Leake; Fiscal Year: 1980
    ..The nature of neurons which resist retrograde degeneration following transection of the cochlear nerve, or long term total or partial destruction of the organ of Corti by neomycin sulfate will be re-evaluated...
  14. MICROSCOPIC STUDIES OF THE INNER EAR
    Joseph Hawkins; Fiscal Year: 1980
    ..indwelling round window electrodes for chronic recording and analysis of the compound action potentials of the cochlear nerve. Pathological changes of the inner ears of experimental animals will be examined by light and electron ..
  15. SENSORY PROCESSES
    JOZEF ZWISLOCKI; Fiscal Year: 1990
    ..the past years and concerns the processing of auditory signals in the middle and inner ear (cochlea), the cochlear nerve, and the ventral cochlear nucleus...
  16. EXPERIMENTAL-THEORETICAL STUDIES OF COCHLEAR MECHANISMS
    Thomas Weiss; Fiscal Year: 1991
    ..of supporting cells, the electromechanical environment of the receptor organ, and the spike discharges of cochlear nerve fibers...
  17. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2009
    ..We determined that the loss of CGRP in knockout mice reduced sound-evoked activity of the cochlear nerve, which would then cause a reduction in the dynamic range of sound perception...
  18. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2005
    ..We determined that the loss of CGRP in knockout mice reduced sound-evoked activity of the cochlear nerve, which would then cause a reduction in the dynamic range of sound perception...
  19. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2007
    ..We determined that the loss of CGRP in knockout mice reduced sound-evoked activity of the cochlear nerve, which would then cause a reduction in the dynamic range of sound perception...
  20. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2004
    ..We determined that the loss of CGRP in knockout mice reduced sound-evoked activity of the cochlear nerve, which would then cause a reduction in the dynamic range of sound perception...
  21. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2006
    ..We determined that the loss of CGRP in knockout mice reduced sound-evoked activity of the cochlear nerve, which would then cause a reduction in the dynamic range of sound perception...
  22. High resolution mapping of the Cochlear nerve using optical stimulation
    Mark Bendett; Fiscal Year: 2006
    ..This research will focus on enhancing the performance of the cochlear implant to allow people to hear speech in a crowded room and even to hear music. [unreadable] [unreadable] [unreadable]..
  23. POSTNATAL AUDITORY FUNCTION DEVELOPMENT
    GEORGE STRAIN; Fiscal Year: 1991
    ..Cochlear microphonic, summating potential, cochlear nerve action potential, and brainstem auditory evoked potential will be recorded using electrodes surgically ..
  24. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 2001
    ..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
  25. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 2000
    ..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
  26. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 2000
    ..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
  27. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 1999
    ..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
  28. OBJECTIVE MEASURE OF LOW-FREQUENCY INNER EAR FUNCTION
    JEFFERY LICHTENHAN; Fiscal Year: 2012
    ..functional measure - the auditory nerve overlapped waveform (ANOW) - which is thought to originate from apical cochlear nerve fibers in response to low-frequency stimuli of low- to moderate-level...
  29. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2000
    ..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
  30. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 1999
    ..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
  31. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2001
    ..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
  32. PERIPHERAL AUDITORY MECHANISMS
    CHARLES MOLNAR; Fiscal Year: 1980
    We continue our studies of cochlear mechanisms in the cat and chinchilla, with emphasis on single cochlear nerve fiber responses to periodic stimuli...
  33. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2002
    ..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
  34. NEUROTRANSMITTERS IN THE AUDITORY SYSTEM
    STEVEN POTASHNER; Fiscal Year: 2003
    ..This injury initially destroyed the cochlear nerve, which carried cochlear excitation into the brain...
  35. ACTIVITY-DEPENDENT DEVELOPMENT OF CALCIUM HOMEOSTASIS
    Lance Zirpel; Fiscal Year: 2001
    ..how neurons in the cochlear nucleus respond to the onset and increasing levels of afferent input from the cochlear nerve during development with the implementation of mechanisms to regulate intracellular ion homeostasis...
  36. ACTIVITY-DEPENDENT DEVELOPMENT OF CALCIUM HOMEOSTASIS
    Lance Zirpel; Fiscal Year: 2002
    ..how neurons in the cochlear nucleus respond to the onset and increasing levels of afferent input from the cochlear nerve during development with the implementation of mechanisms to regulate intracellular ion homeostasis...
  37. ACTIVITY-DEPENDENT DEVELOPMENT OF CALCIUM HOMEOSTASIS
    Lance Zirpel; Fiscal Year: 2000
    ..how neurons in the cochlear nucleus respond to the onset and increasing levels of afferent input from the cochlear nerve during development with the implementation of mechanisms to regulate intracellular ion homeostasis...
  38. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 1990
    ..The proposed studies should provide crucial normative data which are required for understanding the mechanisms by which disease alters the development of structure and function in the auditory periphery...
  39. IOWA COCHLEAR IMPLANT PROJECT
    Bruce Gantz; Fiscal Year: 1990
    ..The relationship between intraoperative measures of cochlear nerve action potentials and performance with an implant will be explored in an electrophysiologic project...
  40. INNER EAR AND CENTRAL AUDITORY DEVELOPMENT
    DONALD MOREST; Fiscal Year: 1991
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as the major incurable otological disorders today, despite recent advances with cochlear prostheses...
  41. AUDITORY DE-AFFERENTATION IN THE STUDY OF TINNITUS
    Clarence Sasaki; Fiscal Year: 1980
    ..for subjective tinnitus, a clinical phenomenon most often produced by cochlear injury or disruption of the cochlear nerve. Development of such a correlate is based upon the hypothesis that tinnitus represents spontaneous neuronal ..
  42. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2002
    ..The net effect of these hair cell actions is the production of discharge activity in the cochlear nerve. Tools are now available to dissect the processes in each of these cellular compartments and examine their ..
  43. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2005
    ..The net effect of these hair cell actions is the production of discharge activity in the cochlear nerve. Tools are now available to dissect the processes in each of these cellular compartments and examine their ..
  44. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2004
    ..The net effect of these hair cell actions is the production of discharge activity in the cochlear nerve. Tools are now available to dissect the processes in each of these cellular compartments and examine their ..
  45. HAIR CELL PATHOPHYSIOLOGY
    James Saunders; Fiscal Year: 2003
    ..The net effect of these hair cell actions is the production of discharge activity in the cochlear nerve. Tools are now available to dissect the processes in each of these cellular compartments and examine their ..
  46. SPEECH CODING IN THE POSTEROVENTRAL COCHLEAR NUCLEUS
    Steven Greenberg; Fiscal Year: 1992
    The neural mechanisms underlying the processing of speech beyond the cochlear nerve are virtually unknown...
  47. SPEECH CODING IN THE POSTEROVENTRAL COCHLEAR NUCLEUS
    Steven Greenberg; Fiscal Year: 1990
    The neural mechanisms underlying the processing of speech beyond the cochlear nerve are virtually unknown...
  48. PERIPHERAL MECHANISMS OF HEARING
    MARIO RUGGERO; Fiscal Year: 1990
    ..inner ear and their neural correlates, the trains of action potentials that travel along the axons of the cochlear nerve. Thus, this proposal seeks to specify the framework upon which cochlear transduction (the conversion of ..
  49. A MODEL OF ENDOLYMPHATIC HYDROPS
    Glen Martin; Fiscal Year: 1990
    ..Finally, behavioral and single cochlear nerve-fiber studies will attempt to determine if deterioration in frequency selectivity is one of the more sensitive ..
  50. High resolution mapping of the Cochlear nerve using optical stimulation
    Jonathon Wells; Fiscal Year: 2009
    ..This research will focus on enhancing the performance of the cochlear implant to allow people to hear speech in a crowded room. ..
  51. INNER EAR AND CENTRAL AUDITORY DEVELOPMENT
    DONALD MOREST; Fiscal Year: 1999
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as the major incurable otological disorders today, despite recent advances with cochlear prostheses...
  52. NEUROANATOMICAL DEVELOPMENT OF THE AUDITORY SYSTEM
    Laura Schweitzer; Fiscal Year: 1990
    ..The methods and specific aims can be summarized as follows: 1) Using horseradish peroxidase, individual cochlear nerve axons will be filled and their images reconstructed to study the development of the topographic organization ..
  53. NEUROGENESIS IN THE AUDITORY SYSTEM
    DONALD MOREST; Fiscal Year: 2004
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as major incurable disorders today...
  54. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2004
    ..Phenotypic analysis revealed a hearing disorder associated with post-natal, primary degeneration of cochlear nerve fibers (without hair cell loss) and a balance disorder associated with a reduction in the size of the ..
  55. NEUROANATOMICAL DEVELOPMENT OF THE AUDITORY SYSTEM
    Laura Schweitzer; Fiscal Year: 1991
    ..The methods and specific aims can be summarized as follows: 1) Using horseradish peroxidase, individual cochlear nerve axons will be filled and their images reconstructed to study the development of the topographic organization ..
  56. NEUROGENESIS IN THE AUDITORY SYSTEM
    DONALD MOREST; Fiscal Year: 2003
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as major incurable disorders today...
  57. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2002
    ..Phenotypic analysis revealed a hearing disorder associated with post-natal, primary degeneration of cochlear nerve fibers (without hair cell loss) and a balance disorder associated with a reduction in the size of the ..
  58. INNER EAR AND CENTRAL AUDITORY DEVELOPMENT
    DONALD MOREST; Fiscal Year: 2000
    Deafness and hearing loss due to damage of the inner ear and cochlear nerve remain as the major incurable otological disorders today, despite recent advances with cochlear prostheses...
  59. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2003
    ..Phenotypic analysis revealed a hearing disorder associated with post-natal, primary degeneration of cochlear nerve fibers (without hair cell loss) and a balance disorder associated with a reduction in the size of the ..