peripheral nerves


Summary: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.

Top Publications

  1. ncbi Repairing injured peripheral nerves: Bridging the gap
    Ronald Deumens
    Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Prog Neurobiol 92:245-76. 2010
  2. pmc Chemokines and the pathophysiology of neuropathic pain
    Fletcher A White
    Department of Cell Biology, Loyola University Chicago, Maywood, IL 60626, USA
    Proc Natl Acad Sci U S A 104:20151-8. 2007
  3. ncbi The origin and development of glial cells in peripheral nerves
    Kristjan R Jessen
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:671-82. 2005
  4. ncbi Growth factor delivery systems and repair strategies for damaged peripheral nerves
    Srinivas Madduri
    Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland
    J Control Release 161:274-82. 2012
  5. ncbi Immune and inflammatory mechanisms in neuropathic pain
    Gila Moalem
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Brain Res Rev 51:240-64. 2006
  6. ncbi Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration
    J Homs
    Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gene Ther 18:622-30. 2011
  7. ncbi Regeneration and repair of peripheral nerves
    Elizabeth O Johnson
    Department of Anatomy, Histology and Embryology, University of Ioannina, School of Medicine, 45110 Ioannina, Greece
    Injury 36:S24-9. 2005
  8. ncbi Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
    Murat Ozcelik
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:4120-31. 2010
  9. ncbi Dextrose 5% in water: fluid medium for maintaining electrical stimulation of peripheral nerves during stimulating catheter placement
    B C H Tsui
    Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    Acta Anaesthesiol Scand 49:1562-5. 2005
  10. ncbi The transcription factor ATF-3 promotes neurite outgrowth
    Rhona Seijffers
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 32:143-54. 2006

Detail Information

Publications313 found, 100 shown here

  1. ncbi Repairing injured peripheral nerves: Bridging the gap
    Ronald Deumens
    Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Prog Neurobiol 92:245-76. 2010
    ..A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries...
  2. pmc Chemokines and the pathophysiology of neuropathic pain
    Fletcher A White
    Department of Cell Biology, Loyola University Chicago, Maywood, IL 60626, USA
    Proc Natl Acad Sci U S A 104:20151-8. 2007
  3. ncbi The origin and development of glial cells in peripheral nerves
    Kristjan R Jessen
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:671-82. 2005
    During the development of peripheral nerves, neural crest cells generate myelinating and non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of the CNS...
  4. ncbi Growth factor delivery systems and repair strategies for damaged peripheral nerves
    Srinivas Madduri
    Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland
    J Control Release 161:274-82. 2012
    Artificial nerve conduits (NCs) are, in certain cases, instrumental for repairing damaged peripheral nerves, although therapeutic efficacy remains often suboptimal...
  5. ncbi Immune and inflammatory mechanisms in neuropathic pain
    Gila Moalem
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Brain Res Rev 51:240-64. 2006
  6. ncbi Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration
    J Homs
    Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gene Ther 18:622-30. 2011
    ..These results prove the utility of AAV8 as a gene therapy vector for Schwann cells to treat myelin disorders or to improve nerve regeneration...
  7. ncbi Regeneration and repair of peripheral nerves
    Elizabeth O Johnson
    Department of Anatomy, Histology and Embryology, University of Ioannina, School of Medicine, 45110 Ioannina, Greece
    Injury 36:S24-9. 2005
    ..Knowledge of these mechanisms allows for the better development of biocompatible nerve grafting material...
  8. ncbi Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
    Murat Ozcelik
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:4120-31. 2010
    ..We conclude that regulation of epithelial-like polarization is a critical determinant of myelin sheath structure and function...
  9. ncbi Dextrose 5% in water: fluid medium for maintaining electrical stimulation of peripheral nerves during stimulating catheter placement
    B C H Tsui
    Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    Acta Anaesthesiol Scand 49:1562-5. 2005
    ..5 mA. Local anesthetic was then injected and the motor response immediately ceased. All blocks were successful and provided excellent pain relief with the continuous infusion of local anesthetics...
  10. ncbi The transcription factor ATF-3 promotes neurite outgrowth
    Rhona Seijffers
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 32:143-54. 2006
    ..Furthermore, ATF-3 promotes long sparsely branched neurites. ATF-3 overexpression did not increase c-Jun expression. ATF-3 may contribute, therefore, to neurite outgrowth by orchestrating the gene expression responses in injured neurons...
  11. ncbi Chemotherapy-induced peripheral neuropathy
    Stefan Quasthoff
    Department of Neurology, Karl Franzens Universitat Graz, Austria
    J Neurol 249:9-17. 2002
    ..The recovery from symptoms is often incomplete and a long period of regeneration is required to restore function. Up to now, no drug is available to reliably prevent or cure chemotherapy-induced neuropathy...
  12. pmc Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves
    Yasuyuki Amoh
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 102:17734-8. 2005
    ..These results suggest that hair follicle stem cells provide an important, accessible, autologous source of adult stem cells for regenerative medicine...
  13. ncbi Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    Heung Yong Jin
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Med Res 40:536-44. 2009
    The aim of this study was to investigate the GLP-1 pathway effect on peripheral nerves using a DPP-IV inhibitor in streptozotocin (STZ)-induced diabetic rats.
  14. ncbi Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
    Rudolf Martini
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strabetae 11, Wuerzburg, Germany
    Glia 56:1566-77. 2008
    ..Knowledge of the molecular mechanisms underlying Schwann cell-macrophage interaction under pathological conditions is an important prerequisite to develop effective treatment strategies for various peripheral nerve disorders...
  15. ncbi Peripheral nerve regeneration within an asymmetrically porous PLGA/Pluronic F127 nerve guide conduit
    Se Heang Oh
    Department of Advanced Materials, Hannam University, 461 6 Jeonmin Dong, Yuseong Gu, Daejeon 305 811, Republic of Korea
    Biomaterials 29:1601-9. 2008
    ..This is probably owing to the effective permeation of nutrients and prevention of fibrous scar tissue invasion as well as the good mechanical strength of the tube to maintain a stable support structure for the nerve regeneration...
  16. ncbi Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function
    Suzhen Chen
    Division of Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3079-86. 2006
    ..These results suggest that disruption of the NRG1-erbB signaling pathway could contribute to the pathogenesis of peripheral neuropathies with hypomyelination and neuropathic pain...
  17. ncbi Peripheral nerve regeneration: an opinion on channels, scaffolds and anisotropy
    Ravi V Bellamkonda
    Neurological Biomaterials and Therapeutics, Laboratory for Neuroengineering, Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University, 313 Ferst Drive, Suite 3108, Atlanta, GA 30332 0535, USA
    Biomaterials 27:3515-8. 2006
    ..The importance of using appropriate animal models and outcome measures in evaluating biomaterials-based scaffolds or other engineered constructs suitability for bridging peripheral nerve gaps is highlighted...
  18. ncbi Perspectives in regeneration and tissue engineering of peripheral nerves
    Stefania Raimondo
    Neuroscience Institute of the Cavalieri Ottolenghi Foundation, University of Turin, Italy
    Ann Anat 193:334-40. 2011
  19. pmc Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions
    Kyoko Itoh
    Neurosciences, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Neurosci 30:624-9. 2005
    ..Taken together, it is likely that L1 on axons binds integrins on Schwann cells, resulting in interactions between axons and Schwann cells that are essential for ensheathment and myelination...
  20. ncbi Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) conduits for peripheral nerve regeneration
    Yu Zhu Bian
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Biomaterials 30:217-25. 2009
    ..Combined with the strong mechanical properties, good nerve regeneration ability and non-toxicity of its degradation products, PHBHHx nerve conduits can be developed into a useful material to repair nerve damage...
  21. pmc Treadmill training promotes axon regeneration in injured peripheral nerves
    Manning J Sabatier
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
    Exp Neurol 211:489-93. 2008
    ..Although axons in peripheral nerves are known to regenerate better than those in the CNS, methods of accelerating regeneration are needed due to ..
  22. ncbi Can therapeutic ultrasound influence the regeneration of peripheral nerves?
    Vanessa Vilela Monte Raso
    Departamento de Biomecanica, Medicina e Reabilitação do, Aparelho Locomotor, Faculdade de Medicina de Ribeirao Preto, USP, Ribeirao Preto, SP, Brazil
    J Neurosci Methods 142:185-92. 2005
    ..The authors conclude that low intensity therapeutic ultrasound enhances nerve regeneration, as demonstrated with significance on the 21st postoperative day...
  23. ncbi Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale
    S H Subramony
    Department of Neurology, University of Mississippi Medical Center, Jackson 39216, USA
    Neurology 64:1261-2. 2005
    ..The authors discuss the problems related to rating scales in the ataxias, report a neurologic rating scale for FA, and demonstrate acceptable interrater reliability of the instrument...
  24. ncbi Transection of peripheral nerves, bridging strategies and effect evaluation
    J IJkema-Paassen
    Department of Medical Physiology, University of Groningen, Ant Deusinglaan 1, bldg 3215, Groningen 9713 AV, The Netherlands
    Biomaterials 25:1583-92. 2004
    Disruption of peripheral nerves due to trauma is a frequently occurring clinical problem. Gaps in the nerve are bridged by guiding the regenerating nerves along autologous grafts or artificial guides...
  25. ncbi Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells
    Christopher M Peters
    Departments of Diagnostic and Biological Sciences, Neuroscience, Psychiatry, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 203:42-54. 2007
    ..An understanding of the factors involved in the development and maintenance of PN may lead to mechanism based therapies that prevent/treat PN and thus improve the survival and quality of life of patients receiving chemotherapy...
  26. pmc Morphological diversity and development of glia in Drosophila
    Volker Hartenstein
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    Glia 59:1237-52. 2011
    ..Glia also surrounds the peripheral nerves and sensory organs; here, one also recognizes perineurial and subperineurial glia, and a third type called "..
  27. ncbi Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
    Ann Anat 193:267-75. 2011
    ..Understanding the pleiotropic effects of cytokines/chemokines, however, requires investigating their highly specific pathways and precise points of action...
  28. pmc Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..The results indicate that early spontaneous activity in injured sensory neurons may play important roles in glia activation and pathological pain...
  29. ncbi Regulation of intrinsic neuronal properties for axon growth and regeneration
    Ferdinando Rossi
    Rita Levi Montalcini Centre for Brain Repair, Department of Neuroscience, University of Turin, Corso Raffaello 30, I 10125 Turin, Italy
    Prog Neurobiol 81:1-28. 2007
    ..In the light of this notion, efficient therapeutic interventions in the injured CNS should combine targeted manipulations of growth control mechanisms with task-specific training and rehabilitation paradigms...
  30. ncbi Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Japan
    J Neurochem 82:1129-36. 2002
    ..In addition to unknown genes, there seemed to be a lot of annotated genes whose role in nerve regeneration remains unknown...
  31. ncbi The nature of neural invasion by pancreatic cancer
    Masato Kayahara
    Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Pancreas 35:218-23. 2007
    ..Neural invasion is one of the most important modes of tumor extension in pancreatobiliary tract cancer. However, the precise pattern of neural invasion and the relationship between neural invasion and nodal involvement are unknown...
  32. ncbi Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties
    Y Inagaki
    Pharmaceutical Research Laboratory, Kirin Brewery Co Ltd, Takasaki, Japan
    Eur J Biochem 267:2955-64. 2000
    Galectin-1 has recently been identified as a factor that regulates initial axonal growth in peripheral nerves after axotomy...
  33. ncbi Will it be possible to produce peripheral nerves?
    Mikael Wiberg
    Department of Surgical and Peri Operative Science Section of Hand and Plastic Surgery, University Hospital, Umea University, Umea, Sweden
    Surg Technol Int 11:303-10. 2003
    ..The donor nerves often are of small calibre and limited number. As functional recovery in peripheral nerve reconstruction is poor, clearly, alternative method for bridging nerve gaps is needed...
  34. pmc Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves
    Tomohiko Okuda
    National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Mol Cell Biol 24:3949-56. 2004
    ..that NDRG1 deficiency leads to Schwann cell dysfunction, suggesting that NDRG1 is essential for maintenance of the myelin sheaths in peripheral nerves. These mice will be used for future analyses of the mechanisms of myelin maintenance.
  35. ncbi The role of evaluation methods in the assessment of peripheral nerve regeneration through synthetic conduits: a systematic review. Laboratory investigation
    Carmen L A M Vleggeert-Lankamp
    Department of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurosurg 107:1168-89. 2007
    ..As a consequence, the new paradigm would incorrectly be judged as successful...
  36. ncbi Anterior coracoscapular ligament and suprascapular nerve entrapment
    B W Avery
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Clin Anat 15:383-6. 2002
    ..Because this ligament, for which we propose the term anterior coracoscapular ligament (ACSL), substantially narrows the suprascapular foramen, it should be considered as a possible etiologic factor in suprascapular nerve entrapment...
  37. ncbi Regeneration and repair of peripheral nerves with different biomaterials: review
    Maria Siemionow
    Department of Plastic Surgery, The Cleveland Clinic, Cleveland, OH 44195, USA
    Microsurgery 30:574-88. 2010
    ..All of the discoveries in the nerve armamentarium are making their way into the clinic, where they are, showing great potential for improving both the extent and rate of functional recovery compared with alternative nerve guides...
  38. pmc Molecular mechanisms of inherited demyelinating neuropathies
    Steven S Scherer
    The University of Pennsylvania Medical School, Philadelphia, Pennsylvania
    Glia 56:1578-89. 2008
    ..Here, we review selected recent developments from work on the molecular mechanisms of these disorders and their implications for treatment strategies...
  39. ncbi Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input
    Thorsten Bartsch
    Headache Group, Institute of Neurology, London, UK
    Brain 125:1496-509. 2002
    ..This mechanism may be important in pain referral from cervical structures to the head and therefore have implications for most forms of primary headache...
  40. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
  41. ncbi Pharmacological characterisation of the spared nerve injury model of neuropathic pain
    Helle Kirstein Erichsen
    Department of Pharmacology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Pain 98:151-61. 2002
    ..The present study has shown that a variety of drugs with proven analgesic potency in other models of chronic pain, have differing analgesic profiles in the SNI model of neuropathic pain...
  42. ncbi Chapter 11: Tissue engineering of peripheral nerves
    Bruno Battiston
    Reconstructive Microsurgery Unit, Department of Orthopedics, C T O Hospital, Turin 10126, Italy
    Int Rev Neurobiol 87:227-49. 2009
    Tissue engineering of peripheral nerves has seen an increasing interest over the last years and, similarly to many other fields of regenerative medicine, great expectations have risen within the general public to its potential clinical ..
  43. ncbi Chapter 8: Current techniques and concepts in peripheral nerve repair
    Maria Siemionow
    Cleveland Clinic, Department of Plastic Surgery, Cleveland, Ohio 44195, USA
    Int Rev Neurobiol 87:141-72. 2009
  44. pmc Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains
    Anilkumar M Pillai
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci Res 87:1773-93. 2009
    ..Electrophysiological measurements of peripheral nerves from Nfasc(NF155) mutants revealed dramatic reductions in nerve conduction velocities...
  45. ncbi Functional regeneration of sensory axons into the adult spinal cord
    M S Ramer
    Neuroscience Research Centre, Guy s, King s and St Thomas School of Biomedical Sciences, London, UK
    Nature 403:312-6. 2000
    ..Neurotrophic factor treatment may thus serve as a viable treatment in promoting recovery from root avulsion injuries. I..
  46. ncbi Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root ganglia
    Ilana Mechaly
    I N S E R M U583, Institut des Neurosciences de Montpellier Hôpital St Eloi 80, rue Augustin Fliche BP 74103 34091 Montpellier cedex 5, France
    Mol Cell Neurosci 32:217-29. 2006
  47. ncbi Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression
    Jenny Fortun
    Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Dis 22:153-64. 2006
  48. ncbi Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons
    Qi Cui
    School of Anatomy and Human Biology, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Mol Cell Neurosci 22:49-61. 2003
    ..Thus, cAMP can act cooperatively with appropriate neurotrophic factors to promote axonal regeneration in the injured adult mammalian central nervous system...
  49. ncbi Reversal of suprascapular neuropathy following arthroscopic repair of massive supraspinatus and infraspinatus rotator cuff tears
    John G Costouros
    Harvard Shoulder Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthroscopy 23:1152-61. 2007
  50. ncbi TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve
    Veronica I Shubayev
    San Diego VA Healthcare System, CA 92161, USA
    Mol Cell Neurosci 31:407-15. 2006
    ..Finally, local application of MMP-9 on TNFalpha-/- nerves increased macrophage recruitment to the lesion. These data suggest that TNFalpha lies upstream of MMP-9 in the pathway of macrophage recruitment to injured peripheral nerve...
  51. ncbi Upregulation of activating transcription factor 3 (ATF3) by intrinsic CNS neurons regenerating axons into peripheral nerve grafts
    G Campbell
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Neurol 192:340-7. 2005
    ..The co-expression of ATF3 with c-jun suggests that interactions between these transcription factors may be important for controlling the program of gene expression necessary for regeneration...
  52. ncbi Functionally selective peripheral nerve stimulation with a flat interface nerve electrode
    Dustin J Tyler
    Neural Engineering Center, Applied Neural Control Lab, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Neural Syst Rehabil Eng 10:294-303. 2002
    ..Simultaneous stimulation with two contacts produced moments about the ankle joint that were a combination of the moments produced by the individual contacts when stimulated separately...
  53. ncbi Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci 26:3319-29. 2006
    ..Targeted expression of tau-green fluorescent protein in the glial cells and ultrastructural analysis of the peripheral nerves allowed us to visualize the glial ensheathment of axons...
  54. ncbi Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves
    Andrew J Sweatt
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Physiol Endocrinol Metab 286:E64-76. 2004
    ..The unique expression of BCATc in neurons of the peripheral nervous system, without coexpression of BCKD, raises new questions about the physiological function of this BCAT isozyme...
  55. ncbi Synchronized reconstitution of muscle fibers, peripheral nerves and blood vessels by murine skeletal muscle-derived CD34(-)/45 (-) cells
    Tetsuro Tamaki
    Muscle Physiology and Cell Biology Unit, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259 1143, Japan
    Histochem Cell Biol 128:349-60. 2007
    ..muscle damage model (C57/BL6N wild-type) resulted in the synchronized reconstitution of blood vessels, peripheral nerves and muscle fibers following significant recovery of total muscle mass (57%) and contractile function (55%), ..
  56. ncbi Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses
    J Menetski
    Department of Immunology and Rheumatology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Neuroscience 149:706-14. 2007
    ..Taken together with data from CCR2-deficient mice, these present data confirm a key role of CCL2/CCR2 axis in pain pathways and suggest that inhibiting this axis may result in novel pain therapies...
  57. ncbi Acute demyelination disrupts the molecular organization of peripheral nervous system nodes
    Edgardo J Arroyo
    Department of Neurology, The University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6077, USA
    J Comp Neurol 479:424-34. 2004
    ..Thus, acute demyelination has distinct effects on the molecular organization of the nodal, paranodal, and juxtaparanodal region, reflecting altered axon-Schwann cell interactions...
  58. ncbi Assessment of nerve excitability in toxic and metabolic neuropathies
    Arun V Krishnan
    Prince of Wales Medical Research Institute and Prince of Wales Clinical School, University of New South Wales, Randwick, Sydney, Australia
    J Peripher Nerv Syst 13:7-26. 2008
  59. ncbi Regenerative arrest of inflamed peripheral nerves: role of nitric oxide
    David S McDonald
    Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Neuroreport 18:1635-40. 2007
    ..Our findings indicate that local inflammatory conditions inhibit regenerative events and that nitric oxide may contribute to these events...
  60. pmc Signals regulating myelination in peripheral nerves and the Schwann cell response to injury
    Thomas D Glenn
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, United States Electronic address
    Curr Opin Neurobiol 23:1041-8. 2013
    In peripheral nerves, Schwann cells form myelin, which facilitates the rapid conduction of action potentials along axons in the vertebrate nervous system...
  61. ncbi Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental study
    Xander Smit
    Department of Plastic and Reconstructive Surgery, Erasmus MC University Medical Center Rotterdam, The Netherlands
    J Neurosurg 101:648-52. 2004
    ..The authors aimed to develop an objective biomechanical method of quantifying nerve adhesions and to use this technique for the evaluation of the efficacy of an autocrosslinked hyaluronic acid (HA) gel as an antiadhesion therapy...
  62. pmc Lithium enhances remyelination of peripheral nerves
    Joelle Makoukji
    Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, University Paris Descartes, 75270 Paris Cedex 06, France
    Proc Natl Acad Sci U S A 109:3973-8. 2012
    ..We studied the influence of LiCl on the remyelination of peripheral nerves. We showed that the treatment of adult mice with LiCl after facial nerve crush injury stimulated the ..
  63. ncbi PDLLA/chondroitin sulfate/chitosan/NGF conduits for peripheral nerve regeneration
    Haixing Xu
    Department of Pharmaceutical Engineering, School of Chemical Engineering, Wuhan University of Technology, Wuhan, PR China
    Biomaterials 32:4506-16. 2011
  64. ncbi Short-latency sensory afferent inhibition: conditioning stimulus intensity, recording site, and effects of 1 Hz repetitive TMS
    M Fischer
    Department of Neurology, Universitatsklinikum Ulm, Ulm, Germany
    Brain Stimul 4:202-9. 2011
    ..Conventionally, one stimulation intensity is used for the conditioning pulse to the peripheral nerve...
  65. pmc Latent addition in motor and sensory fibres of human peripheral nerve
    H Bostock
    Institute of Neurology, Queen Square, London, UK
    J Physiol 498:277-94. 1997
    ..These "threshold channels' may help to account for the longer strength-duration time constant of sensory fibres, for their lower rheobase, and for their greater tendency to fire repetitively...
  66. ncbi Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    R W Colburn
    Department of Pharmacology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neuroimmunol 79:163-75. 1997
    ..The current findings support the use of bupivacaine as a tool to suppress microglial activation and challenge the putative role of microglia in initiating or potentiating pain behaviors which result from nerve injury...
  67. pmc Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways
    J Yager
    Department of Biochemistry and Cell Biology, MS 140, Rice University, Houston, TX 77005, USA
    Proc Natl Acad Sci U S A 98:10445-50. 2001
    Drosophila peripheral nerves, similar structurally to the peripheral nerves of mammals, comprise a layer of axons and inner glia, surrounded by an outer perineurial glial layer...
  68. ncbi Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency
    Sérgio Luiz Gomes Antunes
    Laboratório de Hanseníase, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 107:246-53. 2012
    ..These results indicate that even in the absence of AFB, these histopathological nerve alterations may justify a PNL diagnosis when observed in conjunction with pertinent clinical, epidemiological and laboratory data...
  69. ncbi Role of stem cells in the regeneration and repair of peripheral nerves
    Zhiwu Ren
    Key Laboratory of People Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, No 28 Fuxing road, Haidian District, Beijing 100853, People s Republic of China
    Rev Neurosci 23:135-43. 2012
    ..In recent years, stem cells have been widely used to repair injured peripheral nerves. The sources of these stem cells are widespread and their effectiveness in the treatment of peripheral nerve ..
  70. ncbi Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
    ..Here we investigated the distribution of Caspr2 during development of peripheral nerves of normal and galactolipids-deficient [ceramide galactosyl transferase (CGT)-/-] mice...
  71. pmc Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerve
    Xiaojun Xie
    Department of Zoology, Cell and Developmental Biology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Development 138:3813-22. 2011 a number of roles in the development of myelinating Schwann cells, one class of glia ensheathing the peripheral nerves of vertebrates...
  72. ncbi Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model
    A Ladak
    Division of Plastic Surgery, University of Alberta, Edmonton, AB, Canada
    Exp Neurol 228:242-52. 2011
    ..The nerve autograft remains the most effective conduit for supporting regeneration across nerve gaps...
  73. pmc Fluorescent peptides highlight peripheral nerves during surgery in mice
    Michael A Whitney
    Department of Pharmacology, University of California at San Diego, La Jolla, California, USA
    Nat Biotechnol 29:352-6. 2011
    ..After systemic injection of a fluorescently labeled version of the peptide in mice, all peripheral nerves are clearly delineated within 2 h...
  74. ncbi Use of stem cells to augment nerve injury repair
    Sarah Walsh
    Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Neurosurgery 65:A80-6. 2009
  75. ncbi The course of the suprascapular nerve in the supraspinatus fossa and its vulnerability in muscle advancement
    Andreas Greiner
    Department of Trauma Surgery, Innsbruck University Hospital, Innsbruck, Austria
    J Shoulder Elbow Surg 12:256-9. 2003
    ..9 cm. Branches of group 1 and the main nerve are at risk of injury when detaching muscle from bone. This risk is minimized by subperiosteal detachment. Branches of group 1 are tensioned when advancing the muscle 1 cm laterally...
  76. ncbi Botulinum toxin's axonal transport from periphery to the spinal cord
    Ivica Matak
    Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia
    Neurochem Int 61:236-9. 2012
    ..Appearance of truncated SNAP-25 in spinal cord following low-dose peripheral BTX-A suggest that the axonal transport of BTX-A occurs commonly following peripheral application...
  77. ncbi Peripheral nerve demyelination in multiple sclerosis
    Sonoko Misawa
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 119:1829-33. 2008
    ..There are a number of case reports describing MS patients associated with demyelinating neuropathy, but its frequency in a whole MS population is unknown...
  78. pmc Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging
    Sunitha Rangaraju
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Aging Cell 8:178-91. 2009
    b>Peripheral nerves from aged animals exhibit features of degeneration, including marked fiber loss, morphological irregularities in myelinated axons and notable reduction in the expression of myelin proteins...
  79. ncbi Peripheral electrical stimulation to induce cortical plasticity: a systematic review of stimulus parameters
    L S Chipchase
    School of Health and Rehabilitations Sciences Physiotherapy, The University of Queensland, Brisbane, Queensland 4072, Australia
    Clin Neurophysiol 122:456-63. 2011
    ..There is insufficient evidence to determine the effect of other stimulation parameters such as frequency and waveform. Further research is needed to confirm whether modulation of these parameters affects plastic change...
  80. ncbi Functional recovery after peripheral nerve injury and implantation of a collagen guide
    Olivier Alluin
    UMR CNRS 6233, Institut des Sciences du Mouvement Etienne Jules MAREY, Equipe Plasticité des Systèmes Nerveux et Musculaires, Universite de la Mediterranee Aix Marseille II, 13288 Marseille Cedex 09, France
    Biomaterials 30:363-73. 2009
    ..nerve guide conduit to the standard clinical procedure of nerve autografting to promote repair of transected peripheral nerves. We assessed behavioral and functional sensori-motor recovery in a rat model of peroneal nerve transection...
  81. ncbi Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A
    Romain Cartoni
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Brain 133:1460-9. 2010
    ..5 microm. Together these data suggest a link between an increased number of mitochondria in axons and a shift in axonal size distribution in mitofusin 2(R94Q) transgenic animals that may contribute to their neurological phenotype...
  82. ncbi Molecular inflammatory mediators in peripheral nerve degeneration and regeneration
    Carlos Rodrigo Cámara-Lemarroy
    Department of Physiology, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico
    Neuroimmunomodulation 17:314-24. 2010
    ..In this review we attempt to integrate the current evidence generated around this issue, and to explore the therapeutic possibilities that arise...
  83. ncbi Role of integrins in peripheral nerves and hereditary neuropathies
    Caterina Berti
    San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132 Milano, Italy
    Neuromolecular Med 8:191-204. 2006
    ..Then we use information derived from recent experiments of targeted mutagenesis in mice to show that, consistent with temporally regulated expression, different integrins serve multiple roles in developing nerve...
  84. ncbi Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts
    P G di Summa
    Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital of Lausanne, Switzerland
    Neuroscience 181:278-91. 2011
    ..Given these results and other advantages of adipose derived stem cells such as ease of harvest and relative abundance, dASC could be a clinically translatable route towards new methods to enhance peripheral nerve repair...
  85. ncbi Usage of signaling in neurodegeneration and regeneration of peripheral nerves by leprosy bacteria
    Anura Rambukkana
    The Rockefeller University, 1230, York Avenue, New York, NY, USA
    Prog Neurobiol 91:102-7. 2010
    ..leprae appear to propagate the bacterial niche and maintain survival within the PNS. These studies may also provide new insights into our understanding of signaling mechanisms involve in both neurodegeneration and neuroregeneration...
  86. ncbi Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves
    Zhongqi Phyllis Wu
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA
    Immunol Lett 135:118-23. 2011
    ..These results suggest that MHCI and MHCI receptors play roles during early stages of PNS development and may provide new targets of therapeutic strategies to promote neuronal outgrowth after PNS injury...
  87. ncbi Neuroactive steroids and peripheral neuropathy
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Rev 57:460-9. 2008
    ..b>Peripheral nerves are able to synthesize and metabolize neuroactive steroids and are a target for these molecules, since they ..
  88. ncbi Comparing peripheral glial cell differentiation in Drosophila and vertebrates
    Floriano Rodrigues
    Institut fur Neurobiologie, Badestr 9, 48149, Munster, Germany
    Cell Mol Life Sci 68:55-69. 2011
    In all complex organisms, the peripheral nerves ensure the portage of information from the periphery to central computing and back again. Axons are in part amazingly long and are accompanied by several different glial cell types...
  89. ncbi Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones
    R C Melcangi
    Department of Endocrinology, University of Milan, Italy
    Prog Neurobiol 60:291-308. 2000
    The process of aging deeply influences morphological and functional parameters of the peripheral nerves. Interestingly, recent observations performed in our laboratory on the rat sciatic nerves have indicated that the deterioration of ..
  90. ncbi Spider silk fibres in artificial nerve constructs promote peripheral nerve regeneration
    C Allmeling
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    Cell Prolif 41:408-20. 2008
    ..In our study, we describe the use of spider silk fibres as a new material in nerve tissue engineering, in a 20-mm sciatic nerve defect in rats...
  91. ncbi Permeability of injured and intact peripheral nerves and dorsal root ganglia
    Stephen E Abram
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Anesthesiology 105:146-53. 2006
    ..sought to determine whether drugs that do not ordinarily cross the blood-nerve barrier will enter the DRG after intravenous or regional injection and to determine whether nerve injury alters drug access to DRGs or peripheral nerves.
  92. pmc TNF-alpha and neuropathic pain--a review
    Lawrence Leung
    Centre for Neurosciences Studies, 18, Stuart Street, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neuroinflammation 7:27. 2010
    ..g., chemokines and p38 MAPK) has indeed inspired a systems approach perspective for future drug development in treating neuropathic pain...
  93. ncbi Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons
    T Hashimoto
    Department of Anatomy and Neurobiology and Cell Biology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Japan
    Exp Brain Res 146:356-68. 2002
    ..Alginate gel is a promising material for use as an implant for peripheral nerve regeneration...
  94. pmc CNS-derived glia ensheath peripheral nerves and mediate motor root development
    Sarah Kucenas
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Nat Neurosci 11:143-51. 2008
    ..These insights reveal a new class of CNS-born glia that critically contributes to motor nerve development...
  95. pmc Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells
    A Saada
    Department of Anatomy and Embryology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Cell Biol 133:159-67. 1996
    ..The GM-CSF molecule was detected by ELISA in medium conditioned by in vitro and in vivo degenerating peripheral nerves as of the 4th h after injury...
  96. ncbi Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy
    Hidenori Horie
    Advanced Research Center for Biological Scienc, Waseda University, Nishitokyo City, Tokyo 202 0021, Japan
    J Neurosci 24:1873-80. 2004
    ..regeneration have been investigated in vivo, but the signals that prompt neurons to send out processes in peripheral nerves after axotomy are not well understood...
  97. ncbi Upregulation of the endosomal-lysosomal pathway in the trembler-J neuropathy
    L Notterpek
    Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 17:4190-200. 1997
    ..These studies suggest that the TrJ mutation alters myelin stability and that the mutant protein is likely degraded via the lysosomal pathway...
  98. ncbi The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
    ..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization...
  99. ncbi Peripheral nerve injury: a review and approach to tissue engineered constructs
    G R Evans
    Division of Plastic Surgery, The University of California, Irvine, Orange, CA 92868, USA
    Anat Rec 263:396-404. 2001
    ..Compared to spinal cord injury, damage to peripheral nerves is considerably more common...
  100. ncbi The electrophysiology of de qi sensations
    Albert Y Leung
    Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, CA, USA
    J Altern Complement Med 12:743-50. 2006
  101. ncbi Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization
    L P Vera-Portocarrero
    Department of Pharmacology, University of Arizona, Health Sciences Center, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
    Neuroscience 140:1311-20. 2006

Research Grants72

  1. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..misfolded amyloid proteins derived from immunoglobulin light chains and affects the heart, gut, kidneys and peripheral nerves. Biopsy studies and animal studies suggest that amyloid light chains cause oxidative stress leading to ..
  2. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..CMT is slowly progressive and CMT patients suffer from degeneration of the peripheral nerves that control sensory information of the foot/leg and hand/arm...
  3. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..The neurological disorders result from demyelinating changes in the peripheral nerves, the spinal cord and changes yet to be defined in the brain...
  4. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..command signals, FES applies spatially and temporally stereotyped patterns of electrical activation to peripheral nerves to achieve movement restoration in spinal cord injured (SCI) persons...
  5. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ..and sensory neuropathy (HMSN) or peroneal muscular atrophy, is made up of a group disorders that affect peripheral nerves. CMT affects both motor and sensory nerves...
  6. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..Therefore, a neurorestorative strategy to repair damaged peripheral nerves is still critically needed to alleviate the persistent symptoms of established DPN...
  7. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2012
    ..devices can now restore arm and hand movements to paralyzed individuals by electrically activating the peripheral nerves. Wheelchair-mounted robotic arms can also provide reach and grasp capabilities to the severely paralyzed...
  8. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..markers of neural injury, inflammation and the expression of neuropeptides important for nociception in the peripheral nerves of the joint as well as in the DRG and spinal cord...
  9. Establishment of Marmoset iPS-derived Cranial Neural Crest Cells
    Steven Farnsworth; Fiscal Year: 2013
    ..cells for dental regenerative goals such as the regeneration of bone, dentin, dental pulp, whole teeth, and peripheral nerves. The development of marmoset iPS-derived CNC cells will accelerate the development of human iPS-derived ..
  10. Role of axoglial CAMs in the organization of myelinated axons
    Elior Peles; Fiscal Year: 2013 the organization of myelinated axons by analyzing the morphology and the molecular organization of peripheral nerves of mutant mice lacking Necl4, as well as mice lacking the cytoskeletal linker protein 4...
  11. A zebrafish model for neural regeneration
    ALLISON F ROSENBERG; Fiscal Year: 2012
    ..Despite their regenerative potential, injuries to peripheral nerves frequently lack a favorable functional outcome and remain an important clinical problem...
  12. Biomimetic scaffolds for targeted peripheral nerve regeneration
    DAVID SHREIBER; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Despite the robust regenerative potential of peripheral nerves, the clinical outcome of nerve repair is often disappointing...
    Sean J Morrison; Fiscal Year: 2013
    ..nervous system (PNS) including sensory, sympathetic, parasympathetic, and enteric ganglia, as well as peripheral nerves. The neural crest includes neural crest stem cells (NCSCs) as well as restricted progenitors...
  14. Recurrent laryngeal nerve connective tissues as a factor in vocal fold paralysis
    Julie M Barkmeier-Kraemer; Fiscal Year: 2013
    ..These findings support Sunderland's theory that connective tissue patterns within peripheral nerves may develop in response to environmental forces to which the nerve is exposed...
  15. Tetrahydrobioperin acts as a pain signaling molecule
    Yessenia M Ibarra; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Damage to peripheral nerves often leads to patient suffering from chronic neuropathic pain...
  16. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John P Capitanio; Fiscal Year: 2010
    ..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...
  17. Generation of monoclonal and polyclonal antibodies to neolacto-series ganglioside
    Amjad A Ilyas; Fiscal Year: 2010
    ..such as specific antibodies is that it is difficult to isolate large quantities of these gangliosides from peripheral nerves. Interestingly, LM1 ganglioside is also present in human red blood cells...
  18. Retraining Spinal Circuits With Robot-Assisted Functional Electrical Stimulation
    Deborah Won; Fiscal Year: 2013
    ..electrical stimulation (FES) is a biomedical therapy by which electrical stimulation is applied to peripheral nerves to artificially generate muscle activation...
  19. Adipokine Secretion Enhancer Synthetic Organic Drug Discovery in Human Adipocytes
    Eric Clinton Seales; Fiscal Year: 2013
    ..cardiovascular disease, fatty liver disease, and diabetic hyperglycemic injury of the eye, heart, kidney and peripheral nerves have reached epidemic proportions in the US and the developed world and exact huge morbidity and cost ..
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..The goal of this proposal is to better understand the peripheral nerves that drive fracture pain, determine whether nerves regulate fracture healing and test whether novel ..
  21. Biomarkers in Diabetic Neuropathy
    EVA LUCILLE FELDMAN; Fiscal Year: 2010
    ..examine differentially expressed genes involved in lipid metabolism in both human sural nerve samples and in peripheral nerves from a relevant animal model, the BKS-db/db mouse...
  22. Molecular mechanisms of perineural invasion in pancreatic cancer
    Haiyong Han; Fiscal Year: 2010
    ..the specific role of NGF and its receptors (TrkA and p75NTR) in the invasion of pancreatic cancer cells into peripheral nerves using in vitro and ex vivo perineural invasion model systems;and 2) to discover and validate additional ..
  23. The Role of Perineurial Glia in PNS Regeneration
    GWENDOLYN LEWIS; Fiscal Year: 2013
    ..When peripheral nerves become injured, the connection between the CNS and tissues is severed, causing sensation and motor control ..
  24. Optogenetic inhibition of motor neuron and muscle activity in vivo
    Scott L Delp; Fiscal Year: 2013
    ..This project will lay the foundation for optogenetic modulation of activity i motor neurons and other peripheral nerves. Successful demonstration of optical inhibition will provide a proof-of-principle for a novel treatment for ..
  25. Alpha M Beta 2 integrin blockade for acute inflammatory neuropathies
    ..objective is to evaluate whether inhibition of alpha M beta2integrin-dependent leukocyte infiltration into peripheral nerves is a specific therapy for acute peripheral nerve inflammation seen in immune-mediated disorders and ..
  26. Profiling and characterizing axonal precursor micro RNAs in regenerating nerve
    Soonmoon Yoo; Fiscal Year: 2013
    ..By contrast, spontaneous axon regeneration occurs following injury of peripheral nerves, although the regenerative capacity declines as the PNS neurons get maturate...
  27. Tissue-Specific Metabolic Reprogramming in Diabetic Complications
    Subramaniam Pennathur; Fiscal Year: 2011 define changes in metabolite levels and flux in three complications-prone tissues, retina, kidney and peripheral nerves. We will extend these studies to humans with T1DM to understand intrinsic differences from non-diabetics in ..
  28. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ..Enhanced infiltration of inflammatory cells into peripheral nerves of GBS patients is strongly suggestive of an immune-mediated pathogenic process...
  29. Peripheral Sensitization as a Novel Mechanism for Pain in Sickle Cell Disease
    Amanda M Brandow; Fiscal Year: 2013
    ..Peripheral sensitization occurs when damage to or change in peripheral nerves result in features of neuropathic pain which can clinically present as hypersensitivity to mechanical or ..
    PETER STACPOOLE; Fiscal Year: 2009
    ..Specific Aim 2: Determine the mechanism of DCA neurotoxicity in peripheral nerves of dosed humans undergoing treatment with DCA...
  31. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2013
    ..objectives of this project are to determine how prions enter the body, infect lymphoid tissue and travel via peripheral nerves to gain access to the central nervous system where they cause disease...
  32. Mechanisms of Neuropathic Pain in Demylenated Nerves
    Fletcher A White; Fiscal Year: 2010
    ..However, the unremitting nature of the neuropathic pain associated with peripheral nerves suggests that factors and/or receptors inherent to the peripheral nerve may be contributing to long-term ..
  33. Mechanisms of postnatal cutaneous afferent development during inflammation
    Michael P Jankowski; Fiscal Year: 2013
    ..the foundation of future experimentation using in vivo siRNA- mediated knockdown of genes in single peripheral nerves in conjunction with ex vivo recording preparations where we will be able to analyze the roles of changes in ..
  34. In vivo feasibility of a peripheral nerve imaging agent
    Stephen B Kahl; Fiscal Year: 2013
    ..intraneuronal targeting moiety which can deliver selected NIR dyes via peripheral injection to image peripheral nerves associated with the site of injection prior to a prostatectomy. Our Specific Aims are: Aim 1...
  35. HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms
    Cecilia M Shikuma; Fiscal Year: 2012
    ..of PBMCs which we hypothesize represent HIV-infected M/M7s responsible for the inflammation surrounding peripheral nerves. Finally, we will assess how individual mitochondrial genomic variations influence the development of HIV-SN...
  36. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2012
    ..While the close anatomic association between mast cells and peripheral nerves may explain why allergic inflammation is particularly adept at perturbing airway neurophysiology, relatively ..
  37. Quantitative MRI of the Human Peripheral Nervous System In Vivo
    RICHARD DARRELL DORTCH; Fiscal Year: 2013
    ..This can be attributed to the technical challenges associated with MRI of peripheral nerves, including the need for higher spatial resolution, a lack of contrast on standard anatomical images, and the ..
    P A Ferchmin; Fiscal Year: 2010
    ..OPs inhibit the acetylcholinesterase (AChE) in brain and peripheral nerves, causing a cholinergic crisis that is fatal if untreated...
  39. Exercise, neurotrophins, and axon regeneration in the PNS
    Arthur W English; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Axon regeneration in peripheral nerves is enhanced by exercise in the form of modest daily treadmill training...
  40. Molecular genetic analysis of ion regulation by glia at the blood-nerve barrier
    HAIG S KESHISHIAN; Fiscal Year: 2012
    ..This cascade is involved in the regulation of extracellular volume in peripheral nerves: nerves defective in this signaling cascade have extensive swelling...
  41. Opioid Receptor Gene Transfer: A Translational Approach to the Treatment of Pain
    Denise Wilkes; Fiscal Year: 2013
    ..The second step is to induce gene expression in peripheral nerves as an approach to the treatment of chronic pain...
  42. Analgesic actions of adenosine A1 receptor along axonal tracts in chronic pain
    Takahiro Takano; Fiscal Year: 2013
    ..As most acupoints are located in close proximity to peripheral nerves, we speculate that local A1 receptor signaling in pain fibers can reduce the transmission of pro-algesic ..
  43. Mechanisms of prion transport
    Richard A Bessen; Fiscal Year: 2013
    ..neuromuscular junction, a peripheral synapse, will be used to study transynaptic spread of prions between peripheral nerves and skeletal muscle cells in vivo, and in mixed neuron-muscle co-cultures in vitro...
  44. Mechanisms of Muscle Afferent Sensitization after Ischemia
    Michael P Jankowski; Fiscal Year: 2013
    ..afferents, respectively during ischemia using in vivo siRNA-mediated knockdown of these genes in single peripheral nerves in conjunction with ex vivo recording preparations...
  45. Evaluation of sensory neuron plasticity following neonatal maternal separation
    ..that NMS in mice produces long-lasting colon hypersensitivity and increased excitability/receptor changes in peripheral nerves innervating the distal colon...
  46. Genetic Control of Microglia and Neural Macrophages
    William S Talbot; Fiscal Year: 2013
    ..Macrophages perform similar functions in peripheral nerves. In disease or after injury, inappropriate activation of microglia and macrophages can cause damage to the ..
  47. Standardization of C-Peptide and HbA1C (UC4)
    Randie Little; Fiscal Year: 2012 insulin deficiency, hyperglycemia, and high risk for development of complications of the eyes, kidneys, peripheral nerves, heart and blood vessels. The disease is highly prevalent, affecting nearly 26 million people in the U.S...
  48. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2010
    ..teased fiber recordings will be made from the dorsal roots in some experiments and from the distal end of peripheral nerves in other experiments...
  49. Elucidating pathological mechanism of DI-CMTC
    Xiang Lei Yang; Fiscal Year: 2013
    ..applicant): Charcot-Marie-Tooth (CMT) disease is a group of inherited disorders that specifically affect the peripheral nerves system and is characterized by progressive muscle atrophy, sensory loss and bone deformities...
  50. Mechanisms of reovirus neural tropism and spread
    Jennifer L Konopka; Fiscal Year: 2010
    ..infect ependymal cells, and cause hydrocephalus, whereas serotype 3 reoviruses spread through peripheral nerves, infect neurons, and cause lethal encephalitis...
  51. Neural-Enabled Prosthesis with Sensorimotor Integration
    Ranu Jung; Fiscal Year: 2011
    ..proposes to develop an advanced prosthetic system that uses electrodes implanted within the fascicles of peripheral nerves to provide upper extremity amputees with sensory feedback and active volitional control of the prosthesis...
  52. Probing Contactin Functions in Central Myelin
    Barbara Ranscht; Fiscal Year: 2012
    ..with paranodal Caspr serves a critical role in orchestrating assembly of paranodal axoglial junctions in peripheral nerves in mice (Boyle et al., 2001), and find preserved functions in central myelin...
  53. Optogenetic Population Clamp to Study Long-term Plasticity in Vitro
    Robert J Butera; Fiscal Year: 2013
    ..have been greatly reduced or eliminated by white matter damage, stroke, or damage to sensory receptors or peripheral nerves. Low-frequency, high-amplitude electrical discharges from population bursting can manifest as seizures, ..
  54. Fibronectin peptide antagonism for chronic inflammatory neuropathies
    ..Our objective is to evaluate whether inhibition of fibronectin-dependent leukocyte infiltration into peripheral nerves is a specific therapy for chronic peripheral nerve inflammation seen in immune-mediated disorders and ..
  55. BACE1 inhibition in injured peripheral nerve and a neuropathy mouse models
    MOHAMED HASSAN FARAH; Fiscal Year: 2013
    ..deletion and pharmacological inhibition of BACE1 markedly accelerate axonal regeneration in the injured peripheral nerves of mice. However, it is unclear how inhibition of BACE1 improves nerve regeneration...
  56. Genetic mechanisms of myelination in zebrafish
    William S Talbot; Fiscal Year: 2013
    ..the operative signals and determine how they direct Schwann cells as they migrate along axons of growing peripheral nerves. We propose to determine which Nrg isoforms guide Schwann cell migration, to determine where these signals ..
  57. Development of a C. elegans genetic model for Charcot-Marie-Tooth Syndrome 4H
    Matthew Buechner; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Charcot-Marie-Tooth Syndrome (CMT) is a series of diseases of the peripheral nerves that cause loss of sensation and muscular dystrophy...
  58. Methylglyoxal and TRPA1 contribution to neuropathic pain in type 2 diabetes
    RYAN B GRIGGS; Fiscal Year: 2013
    ..By understanding how changes in peripheral nerves lead to alteration of sensory processing in the spinal cord we can learn how to effectively treat painful ..
  59. Development and Validation of Measures of Pain Behaviors in Chronic Pain
    KARON FRANCES COOK; Fiscal Year: 2010
    ..headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any ..
  60. Dissection of genetic pathways critical for myelinating Schwann cell development
    Anthony Antonellis; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Schwann cells are a critical component of peripheral nerves-structures essential for mobility and sensation in the hands and feet...
  61. Functional integration of elongated axon-electrode array constructs with the peri
    HAN CHIAO I CHEN; Fiscal Year: 2012
    ..As opposed to the insertion of electrodes into peripheral nerves, the proposed strategy relies upon a biological interface with the host nervous system, which provides the ..
  62. Non-Invasive Imaging to Quantify Peripheral Nerve Injury and Repair in Clinic
    Kazim A Sheikh; Fiscal Year: 2013
    ..provided by applicant): Civilian and combat trauma to limbs often results in serious injuries to the peripheral nerves that cause significant morbidity...
  63. Exercise-Facilitated NeuroRehabilitation in Diabetic Neuropathy
    EVAN STUBBS; Fiscal Year: 2009
    ..13) Therapeutic interventions that improve blood flow to peripheral nerves, such as exercise, are expected to slow or perhaps reverse the progression of neuropathy in the diabetic ..
  64. The role of Pak1 in regulating plexiform neurofibroma formation
    Andrew McDaniel; Fiscal Year: 2009
    ..These tumors affect the peripheral nerves and commonly can be found in the face, limbs, or along the spinal nerve roots...
    George Smith; Fiscal Year: 2006 regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  66. Fetal Ethanol Effects on the Peripheral Nervous System
    Mary Johnson; Fiscal Year: 2004
    ..This system includes motor and sensory neurons, their glia (Schwann cells), peripheral nerves, neuromuscular junctions, and muscle cells...
  67. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2009
    ..Blocking of the contraction process in healing peripheral nerves in rats will be studied primarily using scaffolds that disorganize contractile cells, preventing their ..
    Riyi Shi; Fiscal Year: 2003
    ..restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
    PHILLIP CHANCE; Fiscal Year: 1992
    ..Disease (Hereditary Motor and Sensory Neuropathy, HMSN) is a heterogeneous group of genetic disorders of peripheral nerves. The biochemical basis of these conditions is unknown...
  70. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..function of most tissues and organs, including muscle, skin, blood vessels, brain, heart, lung, kidney, and peripheral nerves. Mutations in genes encoding basement membrane components result in severe inherited disorders in humans, e...
    James Kramer; Fiscal Year: 2004
    ..g., muscle, skin, blood vessels, heart, lung, kidney, and peripheral nerves. For example, basement membranes regulate the migration and organization of ceils in the musculoskeletal ..
  72. Matrix Control of Glial/Axonal Interactions in Developing Nerves
    Bruce Patton; Fiscal Year: 2009
    ..Schwann cells in myelinated peripheral nerves establish 1:1 relationships with axons...