peripheral nerves

Summary

Summary: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.

Top Publications

  1. ncbi Repairing injured peripheral nerves: Bridging the gap
    Ronald Deumens
    Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Prog Neurobiol 92:245-76. 2010
  2. ncbi Will it be possible to produce peripheral nerves?
    Mikael Wiberg
    Department of Surgical and Peri Operative Science Section of Hand and Plastic Surgery, University Hospital, Umea University, Umea, Sweden
    Surg Technol Int 11:303-10. 2003
  3. doi Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
    Murat Ozcelik
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:4120-31. 2010
  4. ncbi Dextrose 5% in water: fluid medium for maintaining electrical stimulation of peripheral nerves during stimulating catheter placement
    B C H Tsui
    Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    Acta Anaesthesiol Scand 49:1562-5. 2005
  5. ncbi The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
  6. ncbi The transcription factor ATF-3 promotes neurite outgrowth
    Rhona Seijffers
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 32:143-54. 2006
  7. ncbi Immune and inflammatory mechanisms in neuropathic pain
    Gila Moalem
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Brain Res Rev 51:240-64. 2006
  8. pmc Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves
    Yasuyuki Amoh
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 102:17734-8. 2005
  9. doi Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    Heung Yong Jin
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Med Res 40:536-44. 2009
  10. doi Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
    Rudolf Martini
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strabetae 11, Wuerzburg, Germany
    Glia 56:1566-77. 2008

Detail Information

Publications277 found, 100 shown here

  1. ncbi Repairing injured peripheral nerves: Bridging the gap
    Ronald Deumens
    Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Prog Neurobiol 92:245-76. 2010
    ..A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries...
  2. ncbi Will it be possible to produce peripheral nerves?
    Mikael Wiberg
    Department of Surgical and Peri Operative Science Section of Hand and Plastic Surgery, University Hospital, Umea University, Umea, Sweden
    Surg Technol Int 11:303-10. 2003
    ..The donor nerves often are of small calibre and limited number. As functional recovery in peripheral nerve reconstruction is poor, clearly, alternative method for bridging nerve gaps is needed...
  3. doi Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
    Murat Ozcelik
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:4120-31. 2010
    ..We conclude that regulation of epithelial-like polarization is a critical determinant of myelin sheath structure and function...
  4. ncbi Dextrose 5% in water: fluid medium for maintaining electrical stimulation of peripheral nerves during stimulating catheter placement
    B C H Tsui
    Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    Acta Anaesthesiol Scand 49:1562-5. 2005
    ..5 mA. Local anesthetic was then injected and the motor response immediately ceased. All blocks were successful and provided excellent pain relief with the continuous infusion of local anesthetics...
  5. ncbi The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
    ..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization...
  6. ncbi The transcription factor ATF-3 promotes neurite outgrowth
    Rhona Seijffers
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 32:143-54. 2006
    ..Furthermore, ATF-3 promotes long sparsely branched neurites. ATF-3 overexpression did not increase c-Jun expression. ATF-3 may contribute, therefore, to neurite outgrowth by orchestrating the gene expression responses in injured neurons...
  7. ncbi Immune and inflammatory mechanisms in neuropathic pain
    Gila Moalem
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Brain Res Rev 51:240-64. 2006
    ....
  8. pmc Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves
    Yasuyuki Amoh
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 102:17734-8. 2005
    ..These results suggest that hair follicle stem cells provide an important, accessible, autologous source of adult stem cells for regenerative medicine...
  9. doi Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    Heung Yong Jin
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Med Res 40:536-44. 2009
    The aim of this study was to investigate the GLP-1 pathway effect on peripheral nerves using a DPP-IV inhibitor in streptozotocin (STZ)-induced diabetic rats.
  10. doi Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
    Rudolf Martini
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strabetae 11, Wuerzburg, Germany
    Glia 56:1566-77. 2008
    ..Knowledge of the molecular mechanisms underlying Schwann cell-macrophage interaction under pathological conditions is an important prerequisite to develop effective treatment strategies for various peripheral nerve disorders...
  11. ncbi The origin and development of glial cells in peripheral nerves
    Kristjan R Jessen
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:671-82. 2005
    During the development of peripheral nerves, neural crest cells generate myelinating and non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of the CNS...
  12. doi Regeneration and repair of peripheral nerves with different biomaterials: review
    Maria Siemionow
    Department of Plastic Surgery, The Cleveland Clinic, Cleveland, OH 44195, USA
    Microsurgery 30:574-88. 2010
    ..All of the discoveries in the nerve armamentarium are making their way into the clinic, where they are, showing great potential for improving both the extent and rate of functional recovery compared with alternative nerve guides...
  13. pmc Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..The results indicate that early spontaneous activity in injured sensory neurons may play important roles in glia activation and pathological pain...
  14. pmc Morphological diversity and development of glia in Drosophila
    Volker Hartenstein
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    Glia 59:1237-52. 2011
    ..Glia also surrounds the peripheral nerves and sensory organs; here, one also recognizes perineurial and subperineurial glia, and a third type called "..
  15. ncbi Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells
    Christopher M Peters
    Departments of Diagnostic and Biological Sciences, Neuroscience, Psychiatry, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 203:42-54. 2007
    ..An understanding of the factors involved in the development and maintenance of PN may lead to mechanism based therapies that prevent/treat PN and thus improve the survival and quality of life of patients receiving chemotherapy...
  16. doi Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
    Ann Anat 193:267-75. 2011
    ..Understanding the pleiotropic effects of cytokines/chemokines, however, requires investigating their highly specific pathways and precise points of action...
  17. ncbi The nature of neural invasion by pancreatic cancer
    Masato Kayahara
    Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Pancreas 35:218-23. 2007
    ..Neural invasion is one of the most important modes of tumor extension in pancreatobiliary tract cancer. However, the precise pattern of neural invasion and the relationship between neural invasion and nodal involvement are unknown...
  18. ncbi Regulation of intrinsic neuronal properties for axon growth and regeneration
    Ferdinando Rossi
    Rita Levi Montalcini Centre for Brain Repair, Department of Neuroscience, University of Turin, Corso Raffaello 30, I 10125 Turin, Italy
    Prog Neurobiol 81:1-28. 2007
    ..In the light of this notion, efficient therapeutic interventions in the injured CNS should combine targeted manipulations of growth control mechanisms with task-specific training and rehabilitation paradigms...
  19. ncbi Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Japan
    J Neurochem 82:1129-36. 2002
    ..In addition to unknown genes, there seemed to be a lot of annotated genes whose role in nerve regeneration remains unknown...
  20. ncbi Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties
    Y Inagaki
    Pharmaceutical Research Laboratory, Kirin Brewery Co Ltd, Takasaki, Japan
    Eur J Biochem 267:2955-64. 2000
    Galectin-1 has recently been identified as a factor that regulates initial axonal growth in peripheral nerves after axotomy...
  21. pmc Molecular mechanisms of inherited demyelinating neuropathies
    Steven S Scherer
    The University of Pennsylvania Medical School, Philadelphia, Pennsylvania
    Glia 56:1578-89. 2008
    ..Here, we review selected recent developments from work on the molecular mechanisms of these disorders and their implications for treatment strategies...
  22. ncbi Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input
    Thorsten Bartsch
    Headache Group, Institute of Neurology, London, UK
    Brain 125:1496-509. 2002
    ..This mechanism may be important in pain referral from cervical structures to the head and therefore have implications for most forms of primary headache...
  23. ncbi Connexin mutations in X-linked Charcot-Marie-Tooth disease
    J Bergoffen
    Department of Neurology, University of Pennsylvania Medical School, Children s Hospital of Philadelphia 19104
    Science 262:2039-42. 1993
    ..These findings, a demonstration of inherited defects in a gap junction protein, suggest that connexin32 plays an important role in peripheral nerve...
  24. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
    ....
  25. ncbi Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses
    J Menetski
    Department of Immunology and Rheumatology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Neuroscience 149:706-14. 2007
    ..Taken together with data from CCR2-deficient mice, these present data confirm a key role of CCL2/CCR2 axis in pain pathways and suggest that inhibiting this axis may result in novel pain therapies...
  26. ncbi Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression
    Jenny Fortun
    Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Dis 22:153-64. 2006
    ....
  27. ncbi Reversal of suprascapular neuropathy following arthroscopic repair of massive supraspinatus and infraspinatus rotator cuff tears
    John G Costouros
    Harvard Shoulder Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthroscopy 23:1152-61. 2007
    ....
  28. ncbi Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons
    Qi Cui
    School of Anatomy and Human Biology, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Mol Cell Neurosci 22:49-61. 2003
    ..Thus, cAMP can act cooperatively with appropriate neurotrophic factors to promote axonal regeneration in the injured adult mammalian central nervous system...
  29. ncbi Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root ganglia
    Ilana Mechaly
    I N S E R M U583, Institut des Neurosciences de Montpellier Hôpital St Eloi 80, rue Augustin Fliche BP 74103 34091 Montpellier cedex 5, France
    Mol Cell Neurosci 32:217-29. 2006
    ....
  30. ncbi Upregulation of activating transcription factor 3 (ATF3) by intrinsic CNS neurons regenerating axons into peripheral nerve grafts
    G Campbell
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Neurol 192:340-7. 2005
    ..The co-expression of ATF3 with c-jun suggests that interactions between these transcription factors may be important for controlling the program of gene expression necessary for regeneration...
  31. ncbi Chemotherapy-induced peripheral neuropathy
    Stefan Quasthoff
    Department of Neurology, Karl Franzens Universitat Graz, Austria
    J Neurol 249:9-17. 2002
    ..The recovery from symptoms is often incomplete and a long period of regeneration is required to restore function. Up to now, no drug is available to reliably prevent or cure chemotherapy-induced neuropathy...
  32. ncbi TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve
    Veronica I Shubayev
    San Diego VA Healthcare System, CA 92161, USA
    Mol Cell Neurosci 31:407-15. 2006
    ..Finally, local application of MMP-9 on TNFalpha-/- nerves increased macrophage recruitment to the lesion. These data suggest that TNFalpha lies upstream of MMP-9 in the pathway of macrophage recruitment to injured peripheral nerve...
  33. doi Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model
    A Ladak
    Division of Plastic Surgery, University of Alberta, Edmonton, AB, Canada
    Exp Neurol 228:242-52. 2011
    ..The nerve autograft remains the most effective conduit for supporting regeneration across nerve gaps...
  34. pmc Fluorescent peptides highlight peripheral nerves during surgery in mice
    Michael A Whitney
    Department of Pharmacology, University of California at San Diego, La Jolla, California, USA
    Nat Biotechnol 29:352-6. 2011
    ..After systemic injection of a fluorescently labeled version of the peptide in mice, all peripheral nerves are clearly delineated within 2 h...
  35. doi Use of stem cells to augment nerve injury repair
    Sarah Walsh
    Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Neurosurgery 65:A80-6. 2009
    ....
  36. doi Botulinum toxin's axonal transport from periphery to the spinal cord
    Ivica Matak
    Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia
    Neurochem Int 61:236-9. 2012
    ..Appearance of truncated SNAP-25 in spinal cord following low-dose peripheral BTX-A suggest that the axonal transport of BTX-A occurs commonly following peripheral application...
  37. ncbi The course of the suprascapular nerve in the supraspinatus fossa and its vulnerability in muscle advancement
    Andreas Greiner
    Department of Trauma Surgery, Innsbruck University Hospital, Innsbruck, Austria
    J Shoulder Elbow Surg 12:256-9. 2003
    ..9 cm. Branches of group 1 and the main nerve are at risk of injury when detaching muscle from bone. This risk is minimized by subperiosteal detachment. Branches of group 1 are tensioned when advancing the muscle 1 cm laterally...
  38. ncbi Transection of peripheral nerves, bridging strategies and effect evaluation
    J IJkema-Paassen
    Department of Medical Physiology, University of Groningen, Ant Deusinglaan 1, bldg 3215, Groningen 9713 AV, The Netherlands
    Biomaterials 25:1583-92. 2004
    Disruption of peripheral nerves due to trauma is a frequently occurring clinical problem. Gaps in the nerve are bridged by guiding the regenerating nerves along autologous grafts or artificial guides...
  39. ncbi Peripheral nerve injury: a review and approach to tissue engineered constructs
    G R Evans
    Division of Plastic Surgery, The University of California, Irvine, Orange, CA 92868, USA
    Anat Rec 263:396-404. 2001
    ..Compared to spinal cord injury, damage to peripheral nerves is considerably more common...
  40. pmc Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions
    Kyoko Itoh
    Neurosciences, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Neurosci 30:624-9. 2005
    ..Taken together, it is likely that L1 on axons binds integrins on Schwann cells, resulting in interactions between axons and Schwann cells that are essential for ensheathment and myelination...
  41. doi Peripheral nerve demyelination in multiple sclerosis
    Sonoko Misawa
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 119:1829-33. 2008
    ..There are a number of case reports describing MS patients associated with demyelinating neuropathy, but its frequency in a whole MS population is unknown...
  42. pmc Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging
    Sunitha Rangaraju
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Aging Cell 8:178-91. 2009
    b>Peripheral nerves from aged animals exhibit features of degeneration, including marked fiber loss, morphological irregularities in myelinated axons and notable reduction in the expression of myelin proteins...
  43. doi Functional recovery after peripheral nerve injury and implantation of a collagen guide
    Olivier Alluin
    UMR CNRS 6233, Institut des Sciences du Mouvement Etienne Jules MAREY, Equipe Plasticité des Systèmes Nerveux et Musculaires, Universite de la Mediterranee Aix Marseille II, 13288 Marseille Cedex 09, France
    Biomaterials 30:363-73. 2009
    ..nerve guide conduit to the standard clinical procedure of nerve autografting to promote repair of transected peripheral nerves. We assessed behavioral and functional sensori-motor recovery in a rat model of peroneal nerve transection...
  44. doi Usage of signaling in neurodegeneration and regeneration of peripheral nerves by leprosy bacteria
    Anura Rambukkana
    The Rockefeller University, 1230, York Avenue, New York, NY, USA
    Prog Neurobiol 91:102-7. 2010
    ..leprae appear to propagate the bacterial niche and maintain survival within the PNS. These studies may also provide new insights into our understanding of signaling mechanisms involve in both neurodegeneration and neuroregeneration...
  45. doi Growth factor delivery systems and repair strategies for damaged peripheral nerves
    Srinivas Madduri
    Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland
    J Control Release 161:274-82. 2012
    Artificial nerve conduits (NCs) are, in certain cases, instrumental for repairing damaged peripheral nerves, although therapeutic efficacy remains often suboptimal...
  46. doi Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A
    Romain Cartoni
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Brain 133:1460-9. 2010
    ..5 microm. Together these data suggest a link between an increased number of mitochondria in axons and a shift in axonal size distribution in mitofusin 2(R94Q) transgenic animals that may contribute to their neurological phenotype...
  47. doi Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts
    P G di Summa
    Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital of Lausanne, Switzerland
    Neuroscience 181:278-91. 2011
    ..Given these results and other advantages of adipose derived stem cells such as ease of harvest and relative abundance, dASC could be a clinically translatable route towards new methods to enhance peripheral nerve repair...
  48. ncbi Molecular inflammatory mediators in peripheral nerve degeneration and regeneration
    Carlos Rodrigo Cámara-Lemarroy
    Department of Physiology, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico
    Neuroimmunomodulation 17:314-24. 2010
    ..In this review we attempt to integrate the current evidence generated around this issue, and to explore the therapeutic possibilities that arise...
  49. doi Peripheral electrical stimulation to induce cortical plasticity: a systematic review of stimulus parameters
    L S Chipchase
    School of Health and Rehabilitations Sciences Physiotherapy, The University of Queensland, Brisbane, Queensland 4072, Australia
    Clin Neurophysiol 122:456-63. 2011
    ..There is insufficient evidence to determine the effect of other stimulation parameters such as frequency and waveform. Further research is needed to confirm whether modulation of these parameters affects plastic change...
  50. ncbi Role of integrins in peripheral nerves and hereditary neuropathies
    Caterina Berti
    San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132 Milano, Italy
    Neuromolecular Med 8:191-204. 2006
    ..Then we use information derived from recent experiments of targeted mutagenesis in mice to show that, consistent with temporally regulated expression, different integrins serve multiple roles in developing nerve...
  51. ncbi Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons
    T Hashimoto
    Department of Anatomy and Neurobiology and Cell Biology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Japan
    Exp Brain Res 146:356-68. 2002
    ..Alginate gel is a promising material for use as an implant for peripheral nerve regeneration...
  52. doi Comparing peripheral glial cell differentiation in Drosophila and vertebrates
    Floriano Rodrigues
    Institut fur Neurobiologie, Badestr 9, 48149, Munster, Germany
    Cell Mol Life Sci 68:55-69. 2011
    In all complex organisms, the peripheral nerves ensure the portage of information from the periphery to central computing and back again. Axons are in part amazingly long and are accompanied by several different glial cell types...
  53. doi Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves
    Zhongqi Phyllis Wu
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA
    Immunol Lett 135:118-23. 2011
    ..These results suggest that MHCI and MHCI receptors play roles during early stages of PNS development and may provide new targets of therapeutic strategies to promote neuronal outgrowth after PNS injury...
  54. ncbi Permeability of injured and intact peripheral nerves and dorsal root ganglia
    Stephen E Abram
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Anesthesiology 105:146-53. 2006
    ..sought to determine whether drugs that do not ordinarily cross the blood-nerve barrier will enter the DRG after intravenous or regional injection and to determine whether nerve injury alters drug access to DRGs or peripheral nerves.
  55. doi Spider silk fibres in artificial nerve constructs promote peripheral nerve regeneration
    C Allmeling
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    Cell Prolif 41:408-20. 2008
    ..In our study, we describe the use of spider silk fibres as a new material in nerve tissue engineering, in a 20-mm sciatic nerve defect in rats...
  56. ncbi Neuroactive steroids and peripheral neuropathy
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Rev 57:460-9. 2008
    ..b>Peripheral nerves are able to synthesize and metabolize neuroactive steroids and are a target for these molecules, since they ..
  57. ncbi Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones
    R C Melcangi
    Department of Endocrinology, University of Milan, Italy
    Prog Neurobiol 60:291-308. 2000
    The process of aging deeply influences morphological and functional parameters of the peripheral nerves. Interestingly, recent observations performed in our laboratory on the rat sciatic nerves have indicated that the deterioration of ..
  58. pmc TNF-alpha and neuropathic pain--a review
    Lawrence Leung
    Centre for Neurosciences Studies, 18, Stuart Street, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neuroinflammation 7:27. 2010
    ..g., chemokines and p38 MAPK) has indeed inspired a systems approach perspective for future drug development in treating neuropathic pain...
  59. pmc CNS-derived glia ensheath peripheral nerves and mediate motor root development
    Sarah Kucenas
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Nat Neurosci 11:143-51. 2008
    ..These insights reveal a new class of CNS-born glia that critically contributes to motor nerve development...
  60. ncbi The role of evaluation methods in the assessment of peripheral nerve regeneration through synthetic conduits: a systematic review. Laboratory investigation
    Carmen L A M Vleggeert-Lankamp
    Department of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurosurg 107:1168-89. 2007
    ..As a consequence, the new paradigm would incorrectly be judged as successful...
  61. pmc Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells
    A Saada
    Department of Anatomy and Embryology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Cell Biol 133:159-67. 1996
    ..The GM-CSF molecule was detected by ELISA in medium conditioned by in vitro and in vivo degenerating peripheral nerves as of the 4th h after injury...
  62. ncbi Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy
    Hidenori Horie
    Advanced Research Center for Biological Scienc, Waseda University, Nishitokyo City, Tokyo 202 0021, Japan
    J Neurosci 24:1873-80. 2004
    ..regeneration have been investigated in vivo, but the signals that prompt neurons to send out processes in peripheral nerves after axotomy are not well understood...
  63. ncbi Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32
    P Anzini
    Department of Neurobiology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Neurosci 17:4545-51. 1997
    ..These observations are consistent with earlier hypotheses suggesting a function of Cx32 as a channel-forming protein that facilitates the communication between the abaxonal and adaxonal aspects of Schwann cell cytoplasm...
  64. pmc Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    BMC Neurosci 3:16. 2002
    ..Two comparisons were made using two sets of triplicate microarrays, naïve versus naïve and naïve versus axotomy...
  65. ncbi The neurobiology of Schwann cells
    R Mirsky
    Department of Anatomy and Developmental Biology, University College London, UK
    Brain Pathol 9:293-311. 1999
    ..Schwann cells signal to mesenchymal cells and influence the development of the connective tissue sheaths of peripheral nerves. The importance of Desert Hedgehog in this process is described...
  66. ncbi Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats
    H Stracke
    Center of Internal Medicine, Department of Endocrinology and Metabolism, University of Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Exp Clin Endocrinol Diabetes 109:330-6. 2001
    ..Unlike treatment with water-soluble thiamine nitrate timely administration of liposoluble prodrug benfotiamine was effective in the prevention of functional damage and of AGE and cmL formation in nerves of diabetic rats...
  67. ncbi Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
    Jeffrey A M Coull
    Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 424:938-42. 2003
    ....
  68. ncbi Pulsed radiofrequency
    Nikolai Bogduk
    University of Newcastle, Department of Clinical Research, Royal Newcastle Center, Newcastle, New South Wales, Australia
    Pain Med 7:396-407. 2006
  69. ncbi Endogenous galanin is required for the full expression of central sensitization following peripheral nerve injury
    B J Kerr
    Centre for Neuroscience Research, Guy s, King s and St Thomas School of Biomedical Sciences, Kings College, Guys Hospital Campus, London SE1 1UL, UK
    Neuroreport 12:3331-4. 2001
    ....
  70. ncbi Neuromuscular manifestations of critical illness
    Charles F Bolton
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 32:140-63. 2005
    ..The information is valuable in deciding treatment and prognosis...
  71. ncbi Bioactive poly(L-lactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration
    Gregory R D Evans
    The Division of Plastic Surgey, The University of California, Irvine, Orange 92868, USA
    Biomaterials 23:841-8. 2002
    ..Although equivalent nerve regeneration to autografts was not achieved, this study provides promising results for further investigation...
  72. ncbi Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci 26:3319-29. 2006
    ..Targeted expression of tau-green fluorescent protein in the glial cells and ultrastructural analysis of the peripheral nerves allowed us to visualize the glial ensheathment of axons...
  73. pmc Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons
    Christine Radtke
    Department of Neurology, LCI 7, P O Box 208018, Yale University School of Medicine, New Haven, CT 06516, USA
    Neurosci Lett 387:85-9. 2005
    ..6 sodium channel, which is the dominant sodium channel at normal nodes, is reconstituted on the regenerated axons...
  74. pmc Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction
    Sarah J L Flatters
    Anaesthesia Research Unit, McGill University, Montreal, Que, Canada
    Pain 122:245-57. 2006
    ..Instead, our data suggest that a paclitaxel-induced abnormality in axonal mitochondria of sensory nerves contributes to paclitaxel-induced pain...
  75. ncbi Form and function: the laminin family of heterotrimers
    H Colognato
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Dev Dyn 218:213-34. 2000
    ....
  76. ncbi Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury
    Audrey Boivin
    Laboratory of Molecular Endocrinology, CHUL Research Center, and Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada G1V 4G2
    J Neurosci 27:12565-76. 2007
    ..Our results provide strong evidence that TLR signaling plays a critical role in orchestrating the innate immune response leading to efficient and rapid clearance of inhibitory myelin debris and nerve regeneration...
  77. ncbi Peripheral nerve injury induces Schwann cells to express two macrophage phenotypes: phagocytosis and the galactose-specific lectin MAC-2
    F Reichert
    Department of Anatomy and Embryology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    J Neurosci 14:3231-45. 1994
    ..Furthermore, a strong positive correlation between levels of MAC-2 expression and the extent of myelin destruction by phagocytosis was observed over a wide range of values...
  78. pmc Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study
    Nicola Latronico
    Department of Anesthesiology Intensive Care, University of Brescia, Spedali Civili, Brescia, Italy
    Crit Care 11:R11. 2007
    ..Although complete electrophysiological tests of peripheral nerves and muscles are essential to diagnose it, they are time-consuming, precluding extensive use in daily ICU ..
  79. ncbi Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization
    L P Vera-Portocarrero
    Department of Pharmacology, University of Arizona, Health Sciences Center, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
    Neuroscience 140:1311-20. 2006
    ....
  80. doi Outcome measures of peripheral nerve regeneration
    Matthew D Wood
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Ann Anat 193:321-33. 2011
    Animal models of nerve compression, crush, and transection injuries of peripheral nerves have been subject to extensive study in order to understand the mechanisms of injury and axon regeneration and to investigate methods to promote ..
  81. ncbi Early somatosensory processing during tonic muscle pain in humans: relation to loss of proprioception and motor 'defensive' strategies
    Simone Rossi
    Dipartimento di Neuroscienze, Sezione Neurologia, U O Neurofisiopatologia, Universita di Siena, Policlinico Le Scotte, Viale Bracci, I 53100 Siena, Italy
    Clin Neurophysiol 114:1351-8. 2003
    ..Movement and imagery of movements are in fact known to reduce mainly pre-central SEP amplitude (i.e. gating effect)...
  82. ncbi Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord
    Kimberly A Moore
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 22:6724-31. 2002
    ..Both of these mechanisms could reduce presynaptic GABA levels and promote a functional loss of GABAergic transmission in the superficial dorsal horn...
  83. doi Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves
    Takashi Yamazaki
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
    J Peripher Nerv Syst 14:165-76. 2009
    ..Furthermore, the immunohistological studies suggested a role of ERK and PDGFR-alpha in axon regeneration as well...
  84. doi Tractography of peripheral nerves and skeletal muscles
    C Khalil
    Service de radiologie et imagerie musculosquelettique, Centre de Consultation et Imagerie de l Appareil Locomoteur, CHRU de Lille, 59037 Lille, France
    Eur J Radiol 76:391-7. 2010
    The assessment of human peripheral nerves and skeletal muscles by means of diffusion tensor imaging and tractograpy has been a recent area of research...
  85. ncbi Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury
    V I Shubayev
    Department of Anesthesiology, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093 0629, USA
    Brain Res 855:83-9. 2000
    ....
  86. ncbi Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain
    A Leung
    Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive #0924, La Jolla, CA 92093-0924, USA
    Pain 91:177-87. 2001
    ..The relationship between central sensitization and regulation of peripheral NMDA-receptor expression requires further investigation...
  87. pmc Mechanisms of neuropathic pain
    James N Campbell
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 52:77-92. 2006
    ..The rapid gain in knowledge about abnormal signaling promises breakthroughs in the treatment of these often debilitating disorders...
  88. ncbi Peripheral nerves: a target for the action of neuroactive steroids
    Roberto C Melcangi
    Department of Endocrinology, University of Milan, Italy
    Brain Res Brain Res Rev 48:328-38. 2005
    ..dihydrotestosterone and 3alpha-diol, stimulate the expression of two important proteins of the myelin of peripheral nerves, the glycoprotein P0 (P0) and the peripheral myelin protein 22 (PMP22)...
  89. pmc Neuron-glia crosstalk gets serious: role in pain hypersensitivity
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    Curr Opin Anaesthesiol 21:570-9. 2008
    ..The subsequent neuron-glia interactions contribute to pain hypersensitivity. This review will briefly discuss novel findings that have shed light on the cellular mechanisms of neuron-glia interactions in persistent pain...
  90. ncbi Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths
    E Parmantier
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Neuron 23:713-24. 1999
    ..that Schwann cell-derived Desert hedgehog (Dhh) signals the formation of the connective tissue sheath around peripheral nerves. mRNAs for dhh and its receptor patched (ptc) are expressed in Schwann cells and perineural mesenchyme, ..
  91. doi Characterization of a novel neuropathic pain model in mice
    Richard Hulse
    Department of Physiology and Pharmacology, University of Bristol, Bristol, UK
    Neuroreport 19:825-9. 2008
    ..In galanin knockout mice, PSNI failed to induce allodynia as previously reported in other neuropathic pain models. PSNI can be used to simultaneously study behavioural and neurophysiological changes in wild-type and transgenic mice...
  92. ncbi Multifocal motor neuropathy: current concepts and controversies
    Eduardo Nobile-Orazio
    Dino Ferrari Centre and Centre of Excellence for Neurodegenerative Diseases, Department of Neurological Sciences, Milan University, IRCCS Ospedale Maggiore Policlinico, and Humanitas Clinical Institute, Milan, Italy
    Muscle Nerve 31:663-80. 2005
    ..These issues are addressed in this review of the main clinical, electrophysiological, immunological, and therapeutic features of this neuropathy...
  93. ncbi Evidence for axonal membrane hyperpolarization in multifocal motor neuropathy with conduction block
    Matthew C Kiernan
    Sobell Department of Neurophysiology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Brain 125:664-75. 2002
    ..It is suggested that the distal hyperpolarization is probably linked to focal depolarization and that the clinical features of MMN are consistent with a depolarizing/hyperpolarizing lesion...
  94. ncbi Neurophysiologic parameters and symptoms in chronic renal failure
    Satu Laaksonen
    Department of Clinical Neurophysiology, Turku University Hospital, PB 52, FIN 20521 Turku, Finland
    Muscle Nerve 25:884-90. 2002
    ..We found no significant change in any of the neurophysiologic parameters following a single hemodialysis session...
  95. doi Short-latency sensory afferent inhibition: conditioning stimulus intensity, recording site, and effects of 1 Hz repetitive TMS
    M Fischer
    Department of Neurology, Universitatsklinikum Ulm, Ulm, Germany
    Brain Stimul 4:202-9. 2011
    ..Conventionally, one stimulation intensity is used for the conditioning pulse to the peripheral nerve...
  96. ncbi A biohybrid system to interface peripheral nerves after traumatic lesions: design of a high channel sieve electrode
    T Stieglitz
    Department of Sensor Systems Microsystems, Fraunhofer Institute for Biomedical Engineering, Ensheimer Strasse 48, D 66386 St Ingbert, Germany
    Biosens Bioelectron 17:685-96. 2002
    ..In this paper, a microdevice for a biohybrid system to interface peripheral nerves after traumatic lesions is presented...
  97. ncbi Neuroprotective effects of neuroactive steroids in the spinal cord and peripheral nerves
    Roberto C Melcangi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 28:1-2. 2006
  98. ncbi The distribution of ganglioside-like moieties in peripheral nerves
    K A Sheikh
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Brain 122:449-60. 1999
    ..1, 1.5) channels at the nodes of Ranvier in peripheral nerves from human, rat and dystrophic mice...
  99. doi Repair of partial nerve injury by bypass nerve grafting with end-to-side neurorrhaphy
    Chunhui Song
    Department of Hand Surgery, Dalian Municipal Central Hospital, Dalian, China
    J Reconstr Microsurg 25:507-15. 2009
    ..End-to-side bypass nerve grafting can significantly improve functional recovery in the nerve with partial injury and may be a useful repair strategy in neuromas-in-continuity...
  100. ncbi Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves
    Andrew J Sweatt
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Physiol Endocrinol Metab 286:E64-76. 2004
    ..The unique expression of BCATc in neurons of the peripheral nervous system, without coexpression of BCKD, raises new questions about the physiological function of this BCAT isozyme...
  101. ncbi Cellular and molecular correlates of the regeneration of adult mammalian CNS axons into peripheral nerve grafts
    P N Anderson
    Department of Anatomy and Developmental Biology, University College London, UK
    Prog Brain Res 117:211-32. 1998
    ....

Research Grants86

  1. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2010
    ..objectives of this project are to determine how prions enter the body, infect lymphoid tissue and travel via peripheral nerves to gain access to the central nervous system where they cause disease...
  2. A Systems Neuroscience Approach for the Study of General Anesthesia
    Emery Brown; Fiscal Year: 2009
    ..This research will also have broad impact on the training of anesthesiologists by placing greater emphasis on systems neuroscience. ..
  3. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ..Enhanced infiltration of inflammatory cells into peripheral nerves of GBS patients is strongly suggestive of an immune-mediated pathogenic process...
  4. A TRIAL OF MESTINON IN POST POLIOMYELITIS SYNDROME
    Rup Tandan; Fiscal Year: 1999
    ..which stimulate synthesis of protein and nucleic acids in muscle cells and regeneration/sprouting in peripheral nerves), are possible contributing factors. There is no specific treatment for PPS...
  5. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony Kincaid; Fiscal Year: 2009
    ..objectives of this project are to determine how prions enter the body, infect lymphoid tissue and travel via peripheral nerves to gain access to the central nervous system where they cause disease...
  6. Intra vs. extracortical command signals to restore six dimensional hand movements
    Dawn Taylor; Fiscal Year: 2009
    ..devices can now restore arm and hand movements to paralyzed individuals by electrically activating the peripheral nerves. Wheelchair-mounted robotic arms can also provide reach and grasp capabilities to the severely paralyzed...
  7. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2010
    ..devices can now restore arm and hand movements to paralyzed individuals by electrically activating the peripheral nerves. Wheelchair-mounted robotic arms can also provide reach and grasp capabilities to the severely paralyzed...
  8. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..OPs inhibit the acetylcholinesterase (AChE) in brain and peripheral nerves, causing a cholinergic crisis that is fatal if untreated...
  9. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey Bove; Fiscal Year: 2009
    ..teased fiber recordings will be made from the dorsal roots in some experiments and from the distal end of peripheral nerves in other experiments...
  10. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2010
    ..teased fiber recordings will be made from the dorsal roots in some experiments and from the distal end of peripheral nerves in other experiments...
  11. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2009
    ..teased fiber recordings will be made from the dorsal roots in some experiments and from the distal end of peripheral nerves in other experiments...
  12. Generation of monoclonal and polyclonal antibodies to neolacto-series ganglioside
    AMJAD ILYAS; Fiscal Year: 2009
    ..such as specific antibodies is that it is difficult to isolate large quantities of these gangliosides from peripheral nerves. Interestingly, LM1 ganglioside is also present in human red blood cells...
  13. Generation of monoclonal and polyclonal antibodies to neolacto-series ganglioside
    Amjad A Ilyas; Fiscal Year: 2010
    ..such as specific antibodies is that it is difficult to isolate large quantities of these gangliosides from peripheral nerves. Interestingly, LM1 ganglioside is also present in human red blood cells...
  14. Exercise-Facilitated NeuroRehabilitation in Diabetic Neuropathy
    EVAN STUBBS; Fiscal Year: 2009
    ..13) Therapeutic interventions that improve blood flow to peripheral nerves, such as exercise, are expected to slow or perhaps reverse the progression of neuropathy in the diabetic ..
  15. Fibronectin peptide antagonism for chronic inflammatory neuropathies
    EROBOGHENE EKAMERENO UBOGU; Fiscal Year: 2011
    ..Our objective is to evaluate whether inhibition of fibronectin-dependent leukocyte infiltration into peripheral nerves is a specific therapy for chronic peripheral nerve inflammation seen in immune-mediated disorders and ..
  16. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    PEDRO FERCHMIN; Fiscal Year: 2009
    ..OPs inhibit the acetylcholinesterase (AChE) in brain and peripheral nerves, causing a cholinergic crisis that is fatal if untreated...
  17. Alpha2-macroglobulin in peripheral nerve injury
    Steven L Gonias; Fiscal Year: 2010
    ..In new unpublished studies, we show that MAC expresses anti-inflammatory activity in injured peripheral nerves and, as a result, may be axonal protective...
  18. CORE--NEUROBIOLOGY
    SERDIA MACK; Fiscal Year: 2005
    ..includes capabilities for extracellular and intracellular recording, patch clamping, recording from peripheral nerves, and hardware and software needed for acquisition and analysis of cardio-respiratory data...
  19. Alpha2-macroglobulin in peripheral nerve injury
    STEVEN GONIAS; Fiscal Year: 2007
    ..In new unpublished studies, we show that MAC expresses anti-inflammatory activity in injured peripheral nerves and, as a result, may be axonal protective...
  20. Alpha2-macroglobulin in peripheral nerve injury
    STEVEN GONIAS; Fiscal Year: 2009
    ..In new unpublished studies, we show that MAC expresses anti-inflammatory activity in injured peripheral nerves and, as a result, may be axonal protective...
  21. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2010
    ..While the close anatomic association between mast cells and peripheral nerves may explain why allergic inflammation is particularly adept at perturbing airway neurophysiology, relatively ..
  22. A TRIAL OF MESTINON IN POST POLIOMYELITIS SYNDROME
    Rup Tandan; Fiscal Year: 2000
    ..which stimulate synthesis of protein and nucleic acids in muscle cells and regeneration/sprouting in peripheral nerves), are possible contributing factors. There is no specific treatment for PPS...
  23. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2011
    ..objectives of this project are to determine how prions enter the body, infect lymphoid tissue and travel via peripheral nerves to gain access to the central nervous system where they cause disease...
  24. Evaluation of sensory neuron plasticity following neonatal maternal separation
    JULIE A CARLSTEN CHRISTIANSON; Fiscal Year: 2010
    ..that NMS in mice produces long-lasting colon hypersensitivity and increased excitability/receptor changes in peripheral nerves innervating the distal colon...
  25. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John Capitanio; Fiscal Year: 2009
    ..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...
  26. Investigating a novel form of Charcot-Marie-Tooth disease
    Sabrina W Yum; Fiscal Year: 2010
    ..at least one- year-old) Nefl-null mice with EM, which showed degenerating myelinated axons not only in peripheral nerves, but also in optic nerve and spinal cord, suggesting that NFL is required for the maintenance of myelinated ..
  27. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..misfolded amyloid proteins derived from immunoglobulin light chains and affects the heart, gut, kidneys and peripheral nerves. Biopsy studies and animal studies suggest that amyloid light chains cause oxidative stress leading to ..
  28. Vascular dysfunction and oxidative stress in primary amyloidosis
    Raymond Migrino; Fiscal Year: 2009
    ..misfolded amyloid proteins derived from immunoglobulin light chains and affects the heart, gut, kidneys and peripheral nerves. Biopsy studies and animal studies suggest that amyloid light chains cause oxidative stress leading to ..
  29. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2010
    ..The goal of this proposal is to better understand the peripheral nerves that drive fracture pain, determine whether nerves regulate fracture healing and test whether novel ..
  30. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    Patrick Mantyh; Fiscal Year: 2009
    ..The goal of this proposal is to better understand the peripheral nerves that drive fracture pain, determine whether nerves regulate fracture healing and test whether novel ..
  31. POLYSOMNOGRAPHIC STUDY OF L759274 AND ZOLPIDEM IN INSOMN
    David Dinges; Fiscal Year: 2000
    ..a family of small peptides that share a common C-terminal sequence, are widely distributed in smooth muscle, peripheral nerves, the spinal cord and the brain...
  32. Peripheral nerve stimulation for amputee pain
    JOSEPH BOGGS; Fiscal Year: 2009
    ..We propose to relieve pain through electrical stimulation of the peripheral nerves (PN) innervating the painful stump and phantom regions...
  33. The role of Pak1 in regulating plexiform neurofibroma formation
    Andrew McDaniel; Fiscal Year: 2007
    ..These tumors affect the peripheral nerves and commonly can be found in the face, limbs, or along the spinal nerve roots...
  34. The role of Pak1 in regulating plexiform neurofibroma formation
    Andrew McDaniel; Fiscal Year: 2009
    ..These tumors affect the peripheral nerves and commonly can be found in the face, limbs, or along the spinal nerve roots...
  35. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD LIEM; Fiscal Year: 2009
    ..CMT is slowly progressive and CMT patients suffer from degeneration of the peripheral nerves that control sensory information of the foot/leg and hand/arm...
  36. TRANSPLANT STUDIES IN GLOBOID CELL LEUKODYSTROPHY
    Andrew Yeager; Fiscal Year: 1992
    ..congenic mice into 10-day-old twitcher mice is associated with prolonged survival and some remyelination in peripheral nerves. The proposed comprehensive studies will further examine the clinical, histopathological, neurochemical, and ..
  37. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..CMT is slowly progressive and CMT patients suffer from degeneration of the peripheral nerves that control sensory information of the foot/leg and hand/arm...
  38. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 1999
    ..The components of M. leprae which bind peripheral nerves and induce nerve damage are not known. The PI proposes that M...
  39. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2000
    ..The components of M. leprae which bind peripheral nerves and induce nerve damage are not known. The PI proposes that M...
  40. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2002
    ..The components of M. leprae which bind peripheral nerves and induce nerve damage are not known. The PI proposes that M...
  41. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2001
    ..The components of M. leprae which bind peripheral nerves and induce nerve damage are not known. The PI proposes that M...
  42. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2003
    ..The components of M. leprae which bind peripheral nerves and induce nerve damage are not known. The PI proposes that M...
  43. fMRI Technology and Analysis
    James Hyde; Fiscal Year: 2009
    ..resting-state functional connectivity maps to study brain plasticity that occurs following surgery to repair peripheral nerves injured by trauma. A rat-brain model of nerve injury of the forearm will be developed at 9.4T...
  44. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2002
    ..to regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  45. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2003
    ..to regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  46. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2005
    ..to regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  47. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2006
    ..to regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  48. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2004
    ..to regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  49. FAILURE OF THE CONTRACTILE PROCESS IN FATIGUE
    Thomas Nosek; Fiscal Year: 1993
    ..the cause of this type of fatigue resides within the muscle rather than in the central nervous system, peripheral nerves, or neuromuscular junction. Therefore, it has been appropriately studied in isolated muscle fibers...
  50. Fetal Ethanol Effects on the Peripheral Nervous System
    Mary Johnson; Fiscal Year: 2003
    ..This system includes motor and sensory neurons, their glia (Schwann cells), peripheral nerves, neuromuscular junctions, and muscle cells...
  51. Fetal Ethanol Effects on the Peripheral Nervous System
    Mary Johnson; Fiscal Year: 2004
    ..This system includes motor and sensory neurons, their glia (Schwann cells), peripheral nerves, neuromuscular junctions, and muscle cells...
  52. Neural-Enabled Prosthesis with Sensorimotor Integration
    Ranu Jung; Fiscal Year: 2009
    ..proposes to develop an advanced prosthetic system that uses electrodes implanted within the fascicles of peripheral nerves to provide upper extremity amputees with sensory feedback and active volitional control of the prosthesis...
  53. Neural-Enabled Prosthesis with Sensorimotor Integration
    Ranu Jung; Fiscal Year: 2007
    ..proposes to develop an advanced prosthetic system that uses electrodes implanted within the fascicles of peripheral nerves to provide upper extremity amputees with sensory feedback and active volitional control of the prosthesis...
  54. Neural-Enabled Prosthesis with Sensorimotor Integration
    Ranu Jung; Fiscal Year: 2010
    ..proposes to develop an advanced prosthetic system that uses electrodes implanted within the fascicles of peripheral nerves to provide upper extremity amputees with sensory feedback and active volitional control of the prosthesis...
  55. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2007
    ..Blocking of the contraction process in healing peripheral nerves in rats will be studied primarily using scaffolds that disorganize contractile cells, preventing their ..
  56. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2006
    ..Blocking of the contraction process in healing peripheral nerves in rats will be studied primarily using scaffolds that disorganize contractile cells, preventing their ..
  57. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2009
    ..Blocking of the contraction process in healing peripheral nerves in rats will be studied primarily using scaffolds that disorganize contractile cells, preventing their ..
  58. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2002
    ..restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
  59. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
  60. EXPERIMENTAL INTRAOPERATIVE RADIOTHERAPY
    EDWARD GILLETTE; Fiscal Year: 1990
    ..following treatment will provide tissues for morphometric analysis of the aorta, arteries, microvasculature, peripheral nerves, muscles, ureters, and lumbar vertebrae...
  61. GENETIC ANALYSIS OF CHARCOT-MARIE-TOOTH DISEASE
    PHILLIP CHANCE; Fiscal Year: 1990
    ..Disease (Hereditary Motor and Sensory Neuropathy, HMSN) is a heterogeneous group of genetic disorders of peripheral nerves. The biochemical basis of these conditions is unknown...
  62. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..function of most tissues and organs, including muscle, skin, blood vessels, brain, heart, lung, kidney, and peripheral nerves. Mutations in genes encoding basement membrane components result in severe inherited disorders in humans, e...
  63. GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANES
    James Kramer; Fiscal Year: 2004
    ..g., muscle, skin, blood vessels, heart, lung, kidney, and peripheral nerves. For example, basement membranes regulate the migration and organization of ceils in the musculoskeletal ..
  64. Genetic mechanisms of myelination in zebrafish
    William S Talbot; Fiscal Year: 2012
    ..the operative signals and determine how they direct Schwann cells as they migrate along axons of growing peripheral nerves. We propose to determine which Nrg isoforms guide Schwann cell migration, to determine where these signals ..
  65. Genetic mechanisms of myelination in zebrafish
    William S Talbot; Fiscal Year: 2010
    ..the operative signals and determine how they direct Schwann cells as they migrate along axons of growing peripheral nerves. We propose to determine which Nrg isoforms guide Schwann cell migration, to determine where these signals ..
  66. Genetic mechanisms of myelination in zebrafish
    WILLIAM TALBOT; Fiscal Year: 2009
    ..the operative signals and determine how they direct Schwann cells as they migrate along axons of growing peripheral nerves. We propose to determine which Nrg isoforms guide Schwann cell migration, to determine where these signals ..
  67. SENSORY AXON PATHFINDING
    MARCIA HONIG; Fiscal Year: 1999
    ..that will project along one peripheral nerve become segregated from axons that will project along other peripheral nerves. The proposed studies will examine how various cell adhesion molecules (CAMs), expressed on the surfaces of ..
  68. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2007
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  69. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  70. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  71. Peripheral Sensitization Following Spinal Cord Injury
    Susan M Carlton; Fiscal Year: 2010
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  72. MICROELECTRODE AND BLOOD FLOW STUDIES IN OPTIC NERVE
    DONALD BUERK; Fiscal Year: 1992
    ..to blood flow measurements in the capillaries of skin, bone, nasal and intestinal mucosa, kidney, brain, peripheral nerves and other tissues...
  73. PRP-SCRAPIE TRANSPORT--INTESTINAL & BLOOD BRAIN BARRIER
    Neena Singh; Fiscal Year: 2002
    ..Possible avenues include indirect spread via peripheral nerves, or directly from peripheral circulation to the brain parenchyma through the blood brain barrier (BBB)...
  74. A zebrafish model for neural regeneration
    ALLISON F ROSENBERG; Fiscal Year: 2010
    ..Despite their regenerative potential, injuries to peripheral nerves frequently lack a favorable functional outcome and remain an important clinical problem...
  75. Genetic Control of Microglia and Neural Macrophages
    William S Talbot; Fiscal Year: 2010
    ..Macrophages perform similar functions in peripheral nerves. In disease or after injury, inappropriate activation of microglia and macrophages can cause damage to the ..
  76. Genetic Control of Microglia and Neural Macrophages
    WILLIAM TALBOT; Fiscal Year: 2009
    ..Macrophages perform similar functions in peripheral nerves. In disease or after injury, inappropriate activation of microglia and macrophages can cause damage to the ..
  77. Matrix Control of Glial/Axonal Interactions in Developing Nerves
    Bruce Patton; Fiscal Year: 2009
    ..Schwann cells in myelinated peripheral nerves establish 1:1 relationships with axons...
  78. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John Capitanio; Fiscal Year: 2007
    ..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...
  79. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John Capitanio; Fiscal Year: 2009
    ..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...