peripheral nerves

Summary

Summary: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.

Top Publications

  1. ncbi The transcription factor ATF-3 promotes neurite outgrowth
    Rhona Seijffers
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 32:143-54. 2006
  2. ncbi Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves
    Yasuyuki Amoh
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 102:17734-8. 2005
  3. ncbi Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    Heung Yong Jin
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Med Res 40:536-44. 2009
  4. ncbi Regulation of intrinsic neuronal properties for axon growth and regeneration
    Ferdinando Rossi
    Rita Levi Montalcini Centre for Brain Repair, Department of Neuroscience, University of Turin, Corso Raffaello 30, I 10125 Turin, Italy
    Prog Neurobiol 81:1-28. 2007
  5. ncbi Immune and inflammatory mechanisms in neuropathic pain
    Gila Moalem
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Brain Res Rev 51:240-64. 2006
  6. ncbi The nature of neural invasion by pancreatic cancer
    Masato Kayahara
    Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Pancreas 35:218-23. 2007
  7. ncbi Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves
    Takashi Yamazaki
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
    J Peripher Nerv Syst 14:165-76. 2009
  8. ncbi Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input
    Thorsten Bartsch
    Headache Group, Institute of Neurology, London, UK
    Brain 125:1496-509. 2002
  9. ncbi Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Japan
    J Neurochem 82:1129-36. 2002
  10. ncbi Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties
    Y Inagaki
    Pharmaceutical Research Laboratory, Kirin Brewery Co Ltd, Takasaki, Japan
    Eur J Biochem 267:2955-64. 2000

Research Grants

  1. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2010
  2. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2010
  3. Alpha2-macroglobulin in peripheral nerve injury
    Steven L Gonias; Fiscal Year: 2010
  4. Alpha2-macroglobulin in peripheral nerve injury
    STEVEN GONIAS; Fiscal Year: 2007
  5. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John Capitanio; Fiscal Year: 2009
  6. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2010
  7. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    Patrick Mantyh; Fiscal Year: 2009
  8. The role of Pak1 in regulating plexiform neurofibroma formation
    Andrew McDaniel; Fiscal Year: 2007
  9. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2003
  10. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2006

Detail Information

Publications241 found, 100 shown here

  1. ncbi The transcription factor ATF-3 promotes neurite outgrowth
    Rhona Seijffers
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 32:143-54. 2006
    ..Furthermore, ATF-3 promotes long sparsely branched neurites. ATF-3 overexpression did not increase c-Jun expression. ATF-3 may contribute, therefore, to neurite outgrowth by orchestrating the gene expression responses in injured neurons...
  2. ncbi Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves
    Yasuyuki Amoh
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 102:17734-8. 2005
    ..These results suggest that hair follicle stem cells provide an important, accessible, autologous source of adult stem cells for regenerative medicine...
  3. ncbi Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    Heung Yong Jin
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Med Res 40:536-44. 2009
    The aim of this study was to investigate the GLP-1 pathway effect on peripheral nerves using a DPP-IV inhibitor in streptozotocin (STZ)-induced diabetic rats.
  4. ncbi Regulation of intrinsic neuronal properties for axon growth and regeneration
    Ferdinando Rossi
    Rita Levi Montalcini Centre for Brain Repair, Department of Neuroscience, University of Turin, Corso Raffaello 30, I 10125 Turin, Italy
    Prog Neurobiol 81:1-28. 2007
    ..In the light of this notion, efficient therapeutic interventions in the injured CNS should combine targeted manipulations of growth control mechanisms with task-specific training and rehabilitation paradigms...
  5. ncbi Immune and inflammatory mechanisms in neuropathic pain
    Gila Moalem
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Brain Res Rev 51:240-64. 2006
    ....
  6. ncbi The nature of neural invasion by pancreatic cancer
    Masato Kayahara
    Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Pancreas 35:218-23. 2007
    ..Neural invasion is one of the most important modes of tumor extension in pancreatobiliary tract cancer. However, the precise pattern of neural invasion and the relationship between neural invasion and nodal involvement are unknown...
  7. ncbi Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves
    Takashi Yamazaki
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
    J Peripher Nerv Syst 14:165-76. 2009
    ..Furthermore, the immunohistological studies suggested a role of ERK and PDGFR-alpha in axon regeneration as well...
  8. ncbi Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input
    Thorsten Bartsch
    Headache Group, Institute of Neurology, London, UK
    Brain 125:1496-509. 2002
    ..This mechanism may be important in pain referral from cervical structures to the head and therefore have implications for most forms of primary headache...
  9. ncbi Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Japan
    J Neurochem 82:1129-36. 2002
    ..In addition to unknown genes, there seemed to be a lot of annotated genes whose role in nerve regeneration remains unknown...
  10. ncbi Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties
    Y Inagaki
    Pharmaceutical Research Laboratory, Kirin Brewery Co Ltd, Takasaki, Japan
    Eur J Biochem 267:2955-64. 2000
    Galectin-1 has recently been identified as a factor that regulates initial axonal growth in peripheral nerves after axotomy...
  11. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
    ....
  12. ncbi Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
    Rudolf Martini
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strabetae 11, Wuerzburg, Germany
    Glia 56:1566-77. 2008
    ..Knowledge of the molecular mechanisms underlying Schwann cell-macrophage interaction under pathological conditions is an important prerequisite to develop effective treatment strategies for various peripheral nerve disorders...
  13. ncbi Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells
    Christopher M Peters
    Departments of Diagnostic and Biological Sciences, Neuroscience, Psychiatry, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 203:42-54. 2007
    ..An understanding of the factors involved in the development and maintenance of PN may lead to mechanism based therapies that prevent/treat PN and thus improve the survival and quality of life of patients receiving chemotherapy...
  14. ncbi Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..The results indicate that early spontaneous activity in injured sensory neurons may play important roles in glia activation and pathological pain...
  15. ncbi The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
    ..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization...
  16. ncbi Chemotherapy-induced peripheral neuropathy
    Stefan Quasthoff
    Department of Neurology, Karl Franzens Universitat Graz, Austria
    J Neurol 249:9-17. 2002
    ..The recovery from symptoms is often incomplete and a long period of regeneration is required to restore function. Up to now, no drug is available to reliably prevent or cure chemotherapy-induced neuropathy...
  17. ncbi Upregulation of activating transcription factor 3 (ATF3) by intrinsic CNS neurons regenerating axons into peripheral nerve grafts
    G Campbell
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Neurol 192:340-7. 2005
    ..The co-expression of ATF3 with c-jun suggests that interactions between these transcription factors may be important for controlling the program of gene expression necessary for regeneration...
  18. ncbi TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve
    Veronica I Shubayev
    San Diego VA Healthcare System, CA 92161, USA
    Mol Cell Neurosci 31:407-15. 2006
    ..Finally, local application of MMP-9 on TNFalpha-/- nerves increased macrophage recruitment to the lesion. These data suggest that TNFalpha lies upstream of MMP-9 in the pathway of macrophage recruitment to injured peripheral nerve...
  19. ncbi Neuroactive steroids and peripheral neuropathy
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Rev 57:460-9. 2008
    ..b>Peripheral nerves are able to synthesize and metabolize neuroactive steroids and are a target for these molecules, since they ..
  20. ncbi Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones
    R C Melcangi
    Department of Endocrinology, University of Milan, Italy
    Prog Neurobiol 60:291-308. 2000
    The process of aging deeply influences morphological and functional parameters of the peripheral nerves. Interestingly, recent observations performed in our laboratory on the rat sciatic nerves have indicated that the deterioration of ..
  21. ncbi Repairing injured peripheral nerves: Bridging the gap
    Ronald Deumens
    Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Prog Neurobiol 92:245-76. 2010
    ..A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries...
  22. ncbi Permeability of injured and intact peripheral nerves and dorsal root ganglia
    Stephen E Abram
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Anesthesiology 105:146-53. 2006
    ..sought to determine whether drugs that do not ordinarily cross the blood-nerve barrier will enter the DRG after intravenous or regional injection and to determine whether nerve injury alters drug access to DRGs or peripheral nerves.
  23. ncbi Spider silk fibres in artificial nerve constructs promote peripheral nerve regeneration
    C Allmeling
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    Cell Prolif 41:408-20. 2008
    ..In our study, we describe the use of spider silk fibres as a new material in nerve tissue engineering, in a 20-mm sciatic nerve defect in rats...
  24. ncbi Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons
    T Hashimoto
    Department of Anatomy and Neurobiology and Cell Biology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Japan
    Exp Brain Res 146:356-68. 2002
    ..Alginate gel is a promising material for use as an implant for peripheral nerve regeneration...
  25. ncbi TNF-alpha and neuropathic pain--a review
    Lawrence Leung
    Centre for Neurosciences Studies, 18, Stuart Street, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neuroinflammation 7:27. 2010
    ..g., chemokines and p38 MAPK) has indeed inspired a systems approach perspective for future drug development in treating neuropathic pain...
  26. ncbi Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves
    Zhongqi Phyllis Wu
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA
    Immunol Lett 135:118-23. 2011
    ..These results suggest that MHCI and MHCI receptors play roles during early stages of PNS development and may provide new targets of therapeutic strategies to promote neuronal outgrowth after PNS injury...
  27. ncbi Comparing peripheral glial cell differentiation in Drosophila and vertebrates
    Floriano Rodrigues
    Institut fur Neurobiologie, Badestr 9, 48149, Munster, Germany
    Cell Mol Life Sci 68:55-69. 2011
    In all complex organisms, the peripheral nerves ensure the portage of information from the periphery to central computing and back again. Axons are in part amazingly long and are accompanied by several different glial cell types...
  28. ncbi CNS-derived glia ensheath peripheral nerves and mediate motor root development
    Sarah Kucenas
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Nat Neurosci 11:143-51. 2008
    ..These insights reveal a new class of CNS-born glia that critically contributes to motor nerve development...
  29. ncbi The role of evaluation methods in the assessment of peripheral nerve regeneration through synthetic conduits: a systematic review. Laboratory investigation
    Carmen L A M Vleggeert-Lankamp
    Department of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurosurg 107:1168-89. 2007
    ..As a consequence, the new paradigm would incorrectly be judged as successful...
  30. ncbi Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy
    Hidenori Horie
    Advanced Research Center for Biological Scienc, Waseda University, Nishitokyo City, Tokyo 202 0021, Japan
    J Neurosci 24:1873-80. 2004
    ..regeneration have been investigated in vivo, but the signals that prompt neurons to send out processes in peripheral nerves after axotomy are not well understood...
  31. ncbi Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells
    A Saada
    Department of Anatomy and Embryology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Cell Biol 133:159-67. 1996
    ..The GM-CSF molecule was detected by ELISA in medium conditioned by in vitro and in vivo degenerating peripheral nerves as of the 4th h after injury...
  32. ncbi Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord
    Kimberly A Moore
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 22:6724-31. 2002
    ..Both of these mechanisms could reduce presynaptic GABA levels and promote a functional loss of GABAergic transmission in the superficial dorsal horn...
  33. ncbi Bioactive poly(L-lactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration
    Gregory R D Evans
    The Division of Plastic Surgey, The University of California, Irvine, Orange 92868, USA
    Biomaterials 23:841-8. 2002
    ..Although equivalent nerve regeneration to autografts was not achieved, this study provides promising results for further investigation...
  34. ncbi Neuromuscular manifestations of critical illness
    Charles F Bolton
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 32:140-63. 2005
    ..The information is valuable in deciding treatment and prognosis...
  35. ncbi Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons
    Christine Radtke
    Department of Neurology, LCI 7, P.O. Box 208018, Yale University School of Medicine, New Haven, CT 06516, USA
    Neurosci Lett 387:85-9. 2005
    ..6 sodium channel, which is the dominant sodium channel at normal nodes, is reconstituted on the regenerated axons...
  36. ncbi Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction
    Sarah J L Flatters
    Anaesthesia Research Unit, McGill University, Montreal, Que, Canada
    Pain 122:245-57. 2006
    ..Instead, our data suggest that a paclitaxel-induced abnormality in axonal mitochondria of sensory nerves contributes to paclitaxel-induced pain...
  37. ncbi Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci 26:3319-29. 2006
    ..Targeted expression of tau-green fluorescent protein in the glial cells and ultrastructural analysis of the peripheral nerves allowed us to visualize the glial ensheathment of axons...
  38. ncbi Form and function: the laminin family of heterotrimers
    H Colognato
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Dev Dyn 218:213-34. 2000
    ....
  39. ncbi Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury
    Audrey Boivin
    Laboratory of Molecular Endocrinology, CHUL Research Center, and Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada G1V 4G2
    J Neurosci 27:12565-76. 2007
    ..Our results provide strong evidence that TLR signaling plays a critical role in orchestrating the innate immune response leading to efficient and rapid clearance of inhibitory myelin debris and nerve regeneration...
  40. ncbi Peripheral nerve injury induces Schwann cells to express two macrophage phenotypes: phagocytosis and the galactose-specific lectin MAC-2
    F Reichert
    Department of Anatomy and Embryology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    J Neurosci 14:3231-45. 1994
    ..Furthermore, a strong positive correlation between levels of MAC-2 expression and the extent of myelin destruction by phagocytosis was observed over a wide range of values...
  41. ncbi Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study
    Nicola Latronico
    Department of Anesthesiology Intensive Care, University of Brescia, Spedali Civili, Brescia, Italy
    Crit Care 11:R11. 2007
    ..Although complete electrophysiological tests of peripheral nerves and muscles are essential to diagnose it, they are time-consuming, precluding extensive use in daily ICU ..
  42. ncbi Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths
    E Parmantier
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Neuron 23:713-24. 1999
    ..that Schwann cell-derived Desert hedgehog (Dhh) signals the formation of the connective tissue sheath around peripheral nerves. mRNAs for dhh and its receptor patched (ptc) are expressed in Schwann cells and perineural mesenchyme, ..
  43. ncbi Neuron-glia crosstalk gets serious: role in pain hypersensitivity
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    Curr Opin Anaesthesiol 21:570-9. 2008
    ..The subsequent neuron-glia interactions contribute to pain hypersensitivity. This review will briefly discuss novel findings that have shed light on the cellular mechanisms of neuron-glia interactions in persistent pain...
  44. ncbi Pulsed radiofrequency
    Nikolai Bogduk
    University of Newcastle, Department of Clinical Research, Royal Newcastle Center, Newcastle, New South Wales, Australia
    Pain Med 7:396-407. 2006
  45. ncbi Mechanisms of neuropathic pain
    James N Campbell
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 52:77-92. 2006
    ..The rapid gain in knowledge about abnormal signaling promises breakthroughs in the treatment of these often debilitating disorders...
  46. ncbi Peripheral nerve injury: a review and approach to tissue engineered constructs
    G R Evans
    Division of Plastic Surgery, The University of California, Irvine, Orange, CA 92868, USA
    Anat Rec 263:396-404. 2001
    ..Compared to spinal cord injury, damage to peripheral nerves is considerably more common...
  47. ncbi Peripheral nerves: a target for the action of neuroactive steroids
    Roberto C Melcangi
    Department of Endocrinology, University of Milan, Italy
    Brain Res Brain Res Rev 48:328-38. 2005
    ..dihydrotestosterone and 3alpha-diol, stimulate the expression of two important proteins of the myelin of peripheral nerves, the glycoprotein P0 (P0) and the peripheral myelin protein 22 (PMP22)...
  48. ncbi Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain
    A Leung
    Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive #0924, La Jolla, CA 92093-0924, USA
    Pain 91:177-87. 2001
    ..The relationship between central sensitization and regulation of peripheral NMDA-receptor expression requires further investigation...
  49. ncbi Characterization of a novel neuropathic pain model in mice
    Richard Hulse
    Department of Physiology and Pharmacology, University of Bristol, Bristol, UK
    Neuroreport 19:825-9. 2008
    ..In galanin knockout mice, PSNI failed to induce allodynia as previously reported in other neuropathic pain models. PSNI can be used to simultaneously study behavioural and neurophysiological changes in wild-type and transgenic mice...
  50. ncbi Evidence for axonal membrane hyperpolarization in multifocal motor neuropathy with conduction block
    Matthew C Kiernan
    Sobell Department of Neurophysiology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Brain 125:664-75. 2002
    ..It is suggested that the distal hyperpolarization is probably linked to focal depolarization and that the clinical features of MMN are consistent with a depolarizing/hyperpolarizing lesion...
  51. ncbi Multifocal motor neuropathy: current concepts and controversies
    Eduardo Nobile-Orazio
    Dino Ferrari Centre and Centre of Excellence for Neurodegenerative Diseases, Department of Neurological Sciences, Milan University, IRCCS Ospedale Maggiore Policlinico, and Humanitas Clinical Institute, Milan, Italy
    Muscle Nerve 31:663-80. 2005
    ..These issues are addressed in this review of the main clinical, electrophysiological, immunological, and therapeutic features of this neuropathy...
  52. ncbi Cellular and molecular correlates of the regeneration of adult mammalian CNS axons into peripheral nerve grafts
    P N Anderson
    Department of Anatomy and Developmental Biology, University College London, UK
    Prog Brain Res 117:211-32. 1998
    ....
  53. ncbi Repair of partial nerve injury by bypass nerve grafting with end-to-side neurorrhaphy
    Chunhui Song
    Department of Hand Surgery, Dalian Municipal Central Hospital, Dalian, China
    J Reconstr Microsurg 25:507-15. 2009
    ..End-to-side bypass nerve grafting can significantly improve functional recovery in the nerve with partial injury and may be a useful repair strategy in neuromas-in-continuity...
  54. ncbi Neuroprotective effects of neuroactive steroids in the spinal cord and peripheral nerves
    Roberto C Melcangi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 28:1-2. 2006
  55. ncbi Regeneration and repair of peripheral nerves with different biomaterials: review
    Maria Siemionow
    Department of Plastic Surgery, The Cleveland Clinic, Cleveland, OH 44195, USA
    Microsurgery 30:574-88. 2010
    ..All of the discoveries in the nerve armamentarium are making their way into the clinic, where they are, showing great potential for improving both the extent and rate of functional recovery compared with alternative nerve guides...
  56. ncbi The distribution of ganglioside-like moieties in peripheral nerves
    K A Sheikh
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Brain 122:449-60. 1999
    ..1, 1.5) channels at the nodes of Ranvier in peripheral nerves from human, rat and dystrophic mice...
  57. ncbi Endogenous galanin is required for the full expression of central sensitization following peripheral nerve injury
    B J Kerr
    Centre for Neuroscience Research, Guy s, King s and St Thomas School of Biomedical Sciences, Kings College, Guys Hospital Campus, London SE1 1UL, UK
    Neuroreport 12:3331-4. 2001
    ....
  58. ncbi Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves
    Andrew J Sweatt
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Physiol Endocrinol Metab 286:E64-76. 2004
    ..The unique expression of BCATc in neurons of the peripheral nervous system, without coexpression of BCKD, raises new questions about the physiological function of this BCAT isozyme...
  59. ncbi Outcome measures of peripheral nerve regeneration
    Matthew D Wood
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Ann Anat 193:321-33. 2011
    Animal models of nerve compression, crush, and transection injuries of peripheral nerves have been subject to extensive study in order to understand the mechanisms of injury and axon regeneration and to investigate methods to promote ..
  60. ncbi Molecular inflammatory mediators in peripheral nerve degeneration and regeneration
    Carlos Rodrigo Cámara-Lemarroy
    Department of Physiology, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico
    Neuroimmunomodulation 17:314-24. 2010
    ..In this review we attempt to integrate the current evidence generated around this issue, and to explore the therapeutic possibilities that arise...
  61. ncbi Successful storage of peripheral nerves using University of Wisconsin solution with polyphenol
    Ryosuke Ikeguchi
    Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Kyoto 606 8507, Japan
    J Neurosci Methods 159:57-65. 2007
    ..Moreover, the electrophysiological results were equal to those of fresh isografts. Polyphenol has the potential to be used for peripheral nerve storage and could be useful for routine peripheral nerve banking...
  62. ncbi Structure and biomechanics of peripheral nerves: nerve responses to physical stresses and implications for physical therapist practice
    Kimberly S Topp
    Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, 1318 7th Ave, Box 0736, San Francisco, CA 94143 0736, USA
    Phys Ther 86:92-109. 2006
    The structural organization of peripheral nerves enables them to function while tolerating and adapting to stresses placed upon them by postures and movements of the trunk, head, and limbs...
  63. ncbi Tractography of peripheral nerves and skeletal muscles
    C Khalil
    Service de radiologie et imagerie musculosquelettique, Centre de Consultation et Imagerie de l Appareil Locomoteur, CHRU de Lille, 59037 Lille, France
    Eur J Radiol 76:391-7. 2010
    The assessment of human peripheral nerves and skeletal muscles by means of diffusion tensor imaging and tractograpy has been a recent area of research...
  64. ncbi Diffusion-direction-dependent imaging: a novel MRI approach for peripheral nerve imaging
    Mikael Skorpil
    Department of Radiology, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Magn Reson Imaging 25:406-11. 2007
    ..Due to inherent anisotropic diffusion properties, peripheral nerves can be visualized on diffusion tensor imaging (DTI)...
  65. ncbi Ultrasound examination of peripheral nerves in the forearm
    Colin J L McCartney
    Department of Anesthesia, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada
    Reg Anesth Pain Med 32:434-9. 2007
    ....
  66. ncbi Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves
    Roberto Pola
    Department of Medicine Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Neurobiol Aging 25:1361-8. 2004
    The physiologic ability of peripheral nerves to regenerate after injury is impaired with aging. However, the mechanisms responsible for this phenomenon are still incompletely characterized...
  67. ncbi The role of nerve allografts and conduits for nerve injuries
    Michael Rivlin
    Department of Orthopaedics, Thomas Jefferson University Hospital, 1015 Walnut Street, Curtis Building, Room 801, Philadelphia, PA 19107, USA
    Hand Clin 26:435-46, viii. 2010
    ..The indications and properties of nerve conduits and allografts are detailed in this article...
  68. ncbi Pulsed radiofrequency neurotomy: advances in pain medicine
    Farshad M Ahadian
    Department of Anesthesiology, Center for Pain and Palliative Medicine, University of California, San Diego, 9500 Gilman Drive 0924, La Jolla, CA 92093 0924, USA
    Curr Pain Headache Rep 8:34-40. 2004
    ..The initial clinical data on PRFN demonstrate response rates similar to conventional high temperature RFN lesions for facet and sacroiliac arthropathy and a host of other chronic pain disorders...
  69. ncbi The reliability and validity of the locognosia test after injuries to peripheral nerves in the hand
    C Jerosch-Herold
    University of East Anglia, Norwich, UK
    J Bone Joint Surg Br 88:1048-52. 2006
    ..0001). The locognosia test has excellent test-retest reliability, is a valid test of tactile spatial discrimination and should be included in the evaluation of outcome after injury to peripheral nerves.
  70. ncbi Development and characterization of a novel human in vitro blood-nerve barrier model using primary endoneurial endothelial cells
    Nejla Yosef
    Neuromuscular Immunopathology Research Laboratory, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    J Neuropathol Exp Neurol 69:82-97. 2010
    ....
  71. ncbi Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves
    Guy A Perkins
    National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0608, USA
    J Struct Biol 161:469-80. 2008
    ..membrane-cytoskeletal, and heterologous cell connections in the paranodal region of the node of Ranvier in peripheral nerves. Focal attachment of cytoskeletal filaments to each other and to the axolemma and paranodal membranes of the ..
  72. ncbi Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis
    David P Yang
    Department of Biological Sciences, Rutgers University, 195 University Ave, Newark, NJ 07102, USA
    Mol Cell Neurosci 38:80-8. 2008
    ..As a result, distal Schwann cell numbers in wild type and cyclin D1 null mice converge to equivalence in regenerated nerves. Therefore, distal Schwann cell proliferation is not required for functional recovery of injured nerves...
  73. ncbi Tumor suppressor schwannomin/merlin is critical for the organization of Schwann cell contacts in peripheral nerves
    Natalia Denisenko
    INSERM, Unité Mixte de Recherche en Santé 839, Paris, 75005, France
    J Neurosci 28:10472-81. 2008
    ..To unravel this role, we studied peripheral nerves in mice overexpressing in Schwann cells schwannomin with a deletion occurring in NF2 patients (P0-SCH-..
  74. ncbi Chapter 9: Artificial scaffolds for peripheral nerve reconstruction
    Valeria Chiono
    Department of Mechanics, Politecnico di Torino, Torino, Italy
    Int Rev Neurobiol 87:173-98. 2009
    ..By an accurate evaluation of the status of research, the review delineates the most promising directions to which research should address for consistent progress in the field of peripheral nerve repair...
  75. ncbi Pulsed radiofrequency treatment: what is the evidence of its effectiveness and should it be used in clinical practice?
    Rollin M Gallagher
    University of Pennsylvania, Philadelphia VA Medical Center, Pennsylvania, USA
    Pain Med 7:408-10. 2006
  76. ncbi Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves
    Jenny F L Chau
    Institute of Molecular Biology, The University of Hong Kong, Hong Kong, SAR, China
    FASEB J 19:1887-9. 2005
    ..The development of the peripheral nerves, including the brachial plexus, facial, vagus, and intercostal nerves, and the phrenic nerve that innervates ..
  77. ncbi Microneurography in rats: a minimally invasive method to record single C-fiber action potentials from peripheral nerves in vivo
    Jordi Serra
    Department of Neurology, MC Mutual, and Neuroscience Technologies, Barcelona, Spain
    Neurosci Lett 470:168-74. 2010
    ..We have tested the feasibility of microneurographic recordings from the peripheral nerves of rats. Tungsten microelectrodes were inserted into the sciatic nerve at mid-thigh level...
  78. ncbi Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration
    S Madduri
    Institute of Pharmaceutical Sciences, ETH Zurich, 8093 Zurich, Switzerland
    Biomaterials 31:2323-34. 2010
    ..Bioactive GDNF and NGF were released in vitro from SF NC over 4 weeks. Thus, the developed functionalized SF NC hold promise to enhance functional recovery of injured peripheral nerves.
  79. ncbi Difference in recovery potential of peripheral nerves after graft repairs
    Zoran Roganovic
    Neurosurgical Department, Military Medical Academy, Belgrade, Serbia and Montenegro
    Neurosurgery 59:621-33; discussion 621-33. 2006
    ..To our knowledge, few studies have been published regarding differences in nerve recovery potentials. In this study, sensory and motor recovery potentials were compared between different nerves...
  80. ncbi Chapter 11: Tissue engineering of peripheral nerves
    Bruno Battiston
    Reconstructive Microsurgery Unit, Department of Orthopedics, C T O Hospital, Turin 10126, Italy
    Int Rev Neurobiol 87:227-49. 2009
    Tissue engineering of peripheral nerves has seen an increasing interest over the last years and, similarly to many other fields of regenerative medicine, great expectations have risen within the general public to its potential clinical ..
  81. ncbi Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain
    Linda R Watkins
    Department of Psychology, Center for Neurosciences, University of Colorado at Boulder, USA
    Adv Exp Med Biol 521:1-21. 2003
    ..The take-home message is that drugs that target glia and the chemical substances that these glia release are predicted to be powerful remedies for pain problems in people...
  82. ncbi Homozygous disruption of the mdrla P-glycoprotein gene affects blood-nerve barrier function in mice administered with neurotoxic drugs
    T Saito
    Department of Otolaryngology, Fukui Medical University, Japan
    Acta Otolaryngol 121:735-42. 2001
    We investigated the expression and function of mdr1a p-glycoprotein in peripheral nerves, including the VIIth and VIIIth nerves, using mdr1a p-glycoprotein gene knockout mice [mdr1a(-/-) mice] and wild-type mdr1a(+/+) mice...
  83. ncbi The microenvironment of injured and regenerating peripheral nerves
    D W Zochodne
    Department of Clinical Neurosciences, University of Calgary, Room 182A, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Muscle Nerve Suppl 9:S33-8. 2000
    ..A better understanding of the injured peripheral nerve microenvironment may allow therapeutic approaches that can enhance regeneration and diminish pain...
  84. ncbi Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves
    K Matsumoto
    Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kawahara cho 53, Shogoin Sakyo ku, 606 8507, Kyoto, Japan
    Brain Res 868:315-28. 2000
    ..Our nerve conduit can guide peripheral nerve elongation and lead to favorable functional recovery across a wider nerve gap than previously reported artificial nerve conduits...
  85. ncbi Negative regulation of myelination: relevance for development, injury, and demyelinating disease
    Kristjan R Jessen
    Department of Cell and Developmental Biology, University College London, London, United Kingdom
    Glia 56:1552-65. 2008
    ..In neuropathies, however, activation of these pathways is likely to be harmful because they may be key contributors to demyelination, a situation which would open new routes for clinical intervention...
  86. ncbi Influence of pulse sequence, polarity and amplitude on magnetic stimulation of human and porcine peripheral nerve
    P J Maccabee
    Departments of Neurology and Physiology, State University of New York, Health Science Centre at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203 2098
    J Physiol 513:571-85. 1998
    ....
  87. ncbi Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    BMC Neurosci 3:16. 2002
    ..Two comparisons were made using two sets of triplicate microarrays, naïve versus naïve and naïve versus axotomy...
  88. ncbi Radiofrequency procedures
    G B Racz
    Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Pain Pract 6:46-50. 2006
    ..Pulsed radiofrequency in particular is a minimally destructive procedure that may offer new opportunities and a broader perspective for therapy with radiofrequency...
  89. ncbi Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats
    Jill A Lindia
    Merck Research Laboratories, Department of Pharmacology, P.O. Box 2000, Rahway, NJ 07065, USA
    Pain 117:145-53. 2005
    ..3 is up-regulated in a subpopulation of DRG neurons after injury, reduction in the expression of NaV1.3 subtype alone is not sufficient to influence the NaV1-dependent behavioral hypersensitivity associated with nerve injury...
  90. ncbi Fatty acid binding protein is induced in neurons of the dorsal root ganglia after peripheral nerve injury
    M De Leon
    Center for Molecular Biology and Gene Therapy, Loma Linda University, CA 92350, USA
    J Neurosci Res 44:283-92. 1996
    ..The induction of DA11 mRNA and protein in DRG neurons suggests, for the first time, the involvement of a neuronal FABP in the process of degeneration and repair in the nervous system...
  91. ncbi Glucose transporters at the blood-nerve barrier are associated with perineurial cells and endoneurial microvessels
    D Z Gerhart
    Department of Biochemistry, School of Medicine, University of Minnesota, Duluth 55812
    Brain Res 508:46-50. 1990
    ..These results support the concept that the blood-nerve barrier serves as an important nutrient delivery system...
  92. ncbi The origin and development of glial cells in peripheral nerves
    Kristjan R Jessen
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:671-82. 2005
    During the development of peripheral nerves, neural crest cells generate myelinating and non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of the CNS...
  93. ncbi Distal axonopathy in peripheral nerves of PMP22-mutant mice
    S Sancho
    Department of Cell Biology, Swiss Federal Institute of Technology and Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    Brain 122:1563-77. 1999
    ..The L3 roots and the peripheral nerves were chosen as representatives of the proximal and distal segments of the peripheral nervous system...
  94. ncbi Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss
    Elizabeth J Ryu
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:11552-9. 2007
    ..Our findings establish the importance of identifying factor(s) responsible for Pou3f1 downregulation during myelination, because they may play important roles in the development of peripheral neuropathies...
  95. ncbi Methodological issues in size estimation of myelinated nerve fibers in peripheral nerves
    S Geuna
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Ospedale San Luigi, Orbassano TO, Italy
    Anat Embryol (Berl) 204:1-10. 2001
    Size estimation of myelinated nerve fibers in peripheral nerves is a very common task in neuromorphology and different dedicated morpho-quantitative procedures have been devised and used to date...
  96. ncbi Insulin therapy protects the central and peripheral nervous system of intensive care patients
    G Van den Berghe
    Department of Intensive Care Medicine, Catholic University of Leuven, B 3000 Leuven, Belgium
    Neurology 64:1348-53. 2005
    ..To investigate the effectiveness of maintaining blood glucose levels below 6.1 mmol/L with insulin as prevention of secondary injury to the central and peripheral nervous systems of intensive care patients...
  97. ncbi An implantable microactuated intrafascicular electrode for peripheral nerves
    Silvia Bossi
    Advanced Robotics Technology and Systems Laboratory, Scuola Superiore Sant Anna, Pontedera I 56025, Italy
    IEEE Trans Biomed Eng 56:2701-6. 2009
    ..The actuation cycle was thermally compatible for biomedical applications. Promising results were obtained from the current ACTIN prototype with an average controlled movement of 7 microm of the peaks...
  98. ncbi Combined nerve and muscle biopsy in the diagnosis of vasculitic neuropathy. A 16-year retrospective study of 202 cases
    Claude Vital
    Neuropathology Laboratory, Victor Segalen University, Bordeaux, France
    J Peripher Nerv Syst 11:20-9. 2006
    ..There were 24 'probable vasculitis' and 68 negative cases. Muscle biopsy improved the yield of definite vasculitis by 27%...
  99. ncbi Sensory neuropathy in vasculitis: a clinical, pathologic, and electrophysiologic study
    J-H Seo
    Department of Rehabilitation Medicine, School of Medicine, Chonbuk National University, Chonju, Republic of Korea
    Neurology 63:874-8. 2004
    ..Non-systemic SNV is usually benign. Of 11 patients followed for longer than 2 years, none developed motor weakness due to neuropathy. CONCLUSION: Sensory neuropathy, regardless of symmetry, can be due to vasculitis...
  100. ncbi Diabetic neuropathy--a review
    Gerard Said
    Service de Neurologie, Centre Hospitalier Universitaire de Bicetre, Universite Paris Sud, 94275 Le Kremlin Bicetre, France
    Nat Clin Pract Neurol 3:331-40. 2007
    ..Conversely, the focal diabetic neuropathies, which are often associated with inflammatory vasculopathy on nerve biopsies, remain self-limited, sometimes after a relapsing course...
  101. ncbi A new type of "bioartificial" nerve graft for bridging extended defects in nerves
    G Lundborg
    Department of Hand Surgery, University Hospital, Lund University, , Sweden
    J Hand Surg Br 22:299-303. 1997
    ..No positive pinch reflex response was elicited in the nerve segment distal to such a tube. We conclude that the new artificial nerve graft can be used to support regeneration across extended gaps in nerves...

Research Grants85

  1. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2010
    ..objectives of this project are to determine how prions enter the body, infect lymphoid tissue and travel via peripheral nerves to gain access to the central nervous system where they cause disease...
  2. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2010
    ..devices can now restore arm and hand movements to paralyzed individuals by electrically activating the peripheral nerves. Wheelchair-mounted robotic arms can also provide reach and grasp capabilities to the severely paralyzed...
  3. Alpha2-macroglobulin in peripheral nerve injury
    Steven L Gonias; Fiscal Year: 2010
    ..In new unpublished studies, we show that MAC expresses anti-inflammatory activity in injured peripheral nerves and, as a result, may be axonal protective...
  4. Alpha2-macroglobulin in peripheral nerve injury
    STEVEN GONIAS; Fiscal Year: 2007
    ..In new unpublished studies, we show that MAC expresses anti-inflammatory activity in injured peripheral nerves and, as a result, may be axonal protective...
  5. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John Capitanio; Fiscal Year: 2009
    ..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...
  6. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2010
    ..The goal of this proposal is to better understand the peripheral nerves that drive fracture pain, determine whether nerves regulate fracture healing and test whether novel ..
  7. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    Patrick Mantyh; Fiscal Year: 2009
    ..The goal of this proposal is to better understand the peripheral nerves that drive fracture pain, determine whether nerves regulate fracture healing and test whether novel ..
  8. The role of Pak1 in regulating plexiform neurofibroma formation
    Andrew McDaniel; Fiscal Year: 2007
    ..These tumors affect the peripheral nerves and commonly can be found in the face, limbs, or along the spinal nerve roots...
  9. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2003
    ..The components of M. leprae which bind peripheral nerves and induce nerve damage are not known. The PI proposes that M...
  10. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2006
    ..to regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  11. Fetal Ethanol Effects on the Peripheral Nervous System
    Mary Johnson; Fiscal Year: 2004
    ..This system includes motor and sensory neurons, their glia (Schwann cells), peripheral nerves, neuromuscular junctions, and muscle cells...
  12. Neural-Enabled Prosthesis with Sensorimotor Integration
    Ranu Jung; Fiscal Year: 2007
    ..proposes to develop an advanced prosthetic system that uses electrodes implanted within the fascicles of peripheral nerves to provide upper extremity amputees with sensory feedback and active volitional control of the prosthesis...
  13. Neural-Enabled Prosthesis with Sensorimotor Integration
    Ranu Jung; Fiscal Year: 2010
    ..proposes to develop an advanced prosthetic system that uses electrodes implanted within the fascicles of peripheral nerves to provide upper extremity amputees with sensory feedback and active volitional control of the prosthesis...
  14. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2007
    ..Blocking of the contraction process in healing peripheral nerves in rats will be studied primarily using scaffolds that disorganize contractile cells, preventing their ..
  15. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2009
    ..Blocking of the contraction process in healing peripheral nerves in rats will be studied primarily using scaffolds that disorganize contractile cells, preventing their ..
  16. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
  17. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..function of most tissues and organs, including muscle, skin, blood vessels, brain, heart, lung, kidney, and peripheral nerves. Mutations in genes encoding basement membrane components result in severe inherited disorders in humans, e...
  18. GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANES
    James Kramer; Fiscal Year: 2004
    ..g., muscle, skin, blood vessels, heart, lung, kidney, and peripheral nerves. For example, basement membranes regulate the migration and organization of ceils in the musculoskeletal ..
  19. Genetic mechanisms of myelination in zebrafish
    William S Talbot; Fiscal Year: 2010
    ..the operative signals and determine how they direct Schwann cells as they migrate along axons of growing peripheral nerves. We propose to determine which Nrg isoforms guide Schwann cell migration, to determine where these signals ..
  20. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  21. Peripheral Sensitization Following Spinal Cord Injury
    Susan M Carlton; Fiscal Year: 2010
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  22. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  23. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2007
    ..forelimbs (above level), the latter being a location where there is no damage to either the spinal cord or peripheral nerves. Our hypothesis is that a reverberating loop is set up beginning with injury-induced release of glutamate in ..
  24. Genetic Control of Microglia and Neural Macrophages
    William S Talbot; Fiscal Year: 2010
    ..Macrophages perform similar functions in peripheral nerves. In disease or after injury, inappropriate activation of microglia and macrophages can cause damage to the ..
  25. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John Capitanio; Fiscal Year: 2007
    ..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...
  26. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John Capitanio; Fiscal Year: 2009
    ..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...