pressoreceptors

Summary

Summary: Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.

Top Publications

  1. pmc Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, University of Sydney, NSW, Australia
    J Physiol 582:711-22. 2007
  2. ncbi Inhibitory neurotransmission in the nucleus tractus solitarii: implications for baroreflex resetting during exercise
    Jeffrey T Potts
    Department of Biomedical Science, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, MO 65211, USA
    Exp Physiol 91:59-72. 2006
  3. ncbi Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers
    Thanh N Doan
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Neurosci 24:3335-43. 2004
  4. ncbi Theoretical analysis of rest and exercise hemodynamics in patients with total cavopulmonary connection
    Elisa Magosso
    Department of Electronics, Computer Science and Systems, University of Bologna, 40136 Bologna, Italy
    Am J Physiol Heart Circ Physiol 282:H1018-34. 2002
  5. ncbi Normalization of arterial pressure after barodenervation: role of pressure natriuresis
    J W Osborn
    Department of Veterinary Biology, University of Minnesota, St Paul 55108
    Am J Physiol 259:R1172-80. 1990
  6. ncbi What sets the long-term level of sympathetic nerve activity: is there a role for arterial baroreceptors?
    Simon C Malpas
    Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 286:R1-R12. 2004
  7. ncbi Arterial baroreflex resetting during exercise: a current perspective
    Peter B Raven
    The Department of Integrative Physiology, University of North Texas, Health Science Center, TX 76107, USA
    Exp Physiol 91:37-49. 2006
  8. ncbi Baroreceptor function during exercise: resetting the record
    Michael J Joyner
    Department of Anaesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Exp Physiol 91:27-36. 2006
  9. ncbi Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone
    R A L Dampney
    Department of Physiology and Institute for Biomedical Research, University of Sydney, New South Wales, Australia
    Acta Physiol Scand 177:209-18. 2003
  10. ncbi A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes
    Yan hua Du
    J Appl Physiol 102:9-10. 2007

Research Grants

Detail Information

Publications213 found, 100 shown here

  1. pmc Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, University of Sydney, NSW, Australia
    J Physiol 582:711-22. 2007
    ..We suggest that this results from activation by Ang II of a central pathway originating at the circumventricular organs...
  2. ncbi Inhibitory neurotransmission in the nucleus tractus solitarii: implications for baroreflex resetting during exercise
    Jeffrey T Potts
    Department of Biomedical Science, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, MO 65211, USA
    Exp Physiol 91:59-72. 2006
    ..An understanding of these mechanisms may prove to be essential for future detailed analysis of the cellular and molecular mechanisms underlying sensory integration in the NTS...
  3. ncbi Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers
    Thanh N Doan
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Neurosci 24:3335-43. 2004
    ..At the sensory receptor terminal, CsCl decreased the threshold pressure for initiation of mechanoreceptor discharge. Therefore, elimination of the I(H) increases excitability of both the soma and the peripheral sensory terminals...
  4. ncbi Theoretical analysis of rest and exercise hemodynamics in patients with total cavopulmonary connection
    Elisa Magosso
    Department of Electronics, Computer Science and Systems, University of Bologna, 40136 Bologna, Italy
    Am J Physiol Heart Circ Physiol 282:H1018-34. 2002
    ..2-1.3 l/min. The model ascribes the poor response to exercise in these patients to the incapacity to sustain venous return caused by the high resistance to venous return and/or to exhaustion of volume compensation reserve...
  5. ncbi Normalization of arterial pressure after barodenervation: role of pressure natriuresis
    J W Osborn
    Department of Veterinary Biology, University of Minnesota, St Paul 55108
    Am J Physiol 259:R1172-80. 1990
    ..These results suggest that the normalization of MAP after ABD or SAD is not the result of pressure natriuresis but rather failure to maintain a chronic elevation of sympathetic activity after barodenervation...
  6. ncbi What sets the long-term level of sympathetic nerve activity: is there a role for arterial baroreceptors?
    Simon C Malpas
    Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 286:R1-R12. 2004
    ....
  7. ncbi Arterial baroreflex resetting during exercise: a current perspective
    Peter B Raven
    The Department of Integrative Physiology, University of North Texas, Health Science Center, TX 76107, USA
    Exp Physiol 91:37-49. 2006
    ....
  8. ncbi Baroreceptor function during exercise: resetting the record
    Michael J Joyner
    Department of Anaesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Exp Physiol 91:27-36. 2006
    ..Additionally, the key contributions of John Shepherd and the late David Donald (along with their colleagues) on related issues are noted...
  9. ncbi Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone
    R A L Dampney
    Department of Physiology and Institute for Biomedical Research, University of Sydney, New South Wales, Australia
    Acta Physiol Scand 177:209-18. 2003
    ..This paper will briefly review some recent findings on the role of glutamate, GABA and angiotensin II (Ang II) receptors in maintaining the tonic activity of RVLM presympathetic neurons...
  10. ncbi A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes
    Yan hua Du
    J Appl Physiol 102:9-10. 2007
  11. ncbi Responses of neurons in paraventricular nucleus to activation of cardiac afferents and acute myocardial ischaemia in rats
    Bo Xu
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Exp Physiol 96:295-304. 2011
    ..Acute myocardial ischaemia activates capsaicin-sensitive neurons in PVN and enhances sympathetic outflow...
  12. ncbi Rheos: an implantable carotid sinus stimulation device for the nonpharmacologic treatment of resistant hypertension
    Maria M Ng
    Department of Medicine, Ronald Reagan UCLA Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
    Cardiol Rev 19:52-7. 2011
    ..Clinical trials designed to evaluate the efficacy and safety of this therapy in patients with treatment resistant hypertension, are now ongoing in both Europe and the United States...
  13. pmc The polyvagal perspective
    Stephen W Porges
    University of Illinois at Chicago, Brain Body Center, Department of Psychiatry, Chicago, IL 60612, USA
    Biol Psychol 74:116-43. 2007
    ....
  14. ncbi The influence of low blood pressure and baroreceptor activity on pain responses
    A Angrilli
    Department of General Psychology, University of Padua, Padova, Italy
    Physiol Behav 62:391-7. 1997
    ..Contrary to expectations, the rate of choice of baroreceptor conditions during painful stimulation did not show, in either group, any preference for baroreceptor activation...
  15. ncbi Increased baroreceptor response in mice deficient in monoamine oxidase A and B
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, LAC USC Hosp, University of Southern California Los Angeles 90024, USA
    Am J Physiol Heart Circ Physiol 282:H964-72. 2002
    ..These data suggest that prevention of hypertension may occur in chronic states of catecholaminergic/indoleaminergic excess by increased gain of the baroreflex...
  16. ncbi Baroreceptors and the long-term control of blood pressure
    Terry N Thrasher
    Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA
    Exp Physiol 89:331-5. 2004
    ..These results strongly suggest that the role of baroreceptors in the long term control of MAP needs to be revisited...
  17. ncbi Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius
    Mark W Doyle
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    J Neurosci 22:8222-9. 2002
    ..Because the CAP sensitivity of cranial afferents is exclusively associated with unmyelinated axons, VR1 identifies C-fiber afferent pathways within the brainstem...
  18. pmc Effects of baroreceptor activation on respiratory variability in rat
    Simon McMullan
    Australian School of Advanced Medicine, Macquarie University, 3 Innovation Road, Sydney, NSW 2109, Australia
    Respir Physiol Neurobiol 166:80-6. 2009
    ..In contrast to the effects of baroreceptor stimulation on sympathetic nerve activity, the baro-respiratory response is subtle and highly dependent on respiratory drive...
  19. ncbi Sensory detection thresholds are modulated across the cardiac cycle: evidence that cutaneous sensibility is greatest for systolic stimulation
    L Edwards
    Department of Human Sciences, Loughborough University, Leicestershire, UK
    Psychophysiology 46:252-6. 2009
    ..The finding that cutaneous sensibility was greater when stimulated during systole than diastole may be accounted for by a modified afferent feedback hypothesis...
  20. ncbi Modulation of the human nociceptive flexion reflex across the cardiac cycle
    L Edwards
    School of Sport and Exercise Sciences, University of Birmingham, United Kingdom
    Psychophysiology 38:712-8. 2001
    ..Stimulation of baroreceptors by natural changes in blood pressure during the cardiac cycle dampened nociception, and accordingly, the data support the arterial baroreflex mechanism of hypertensive hypoalgesia...
  21. ncbi Acute device-based blood pressure reduction: electrical activation of the carotid baroreflex in patients undergoing elective carotid surgery
    Jurg Schmidli
    Department of Cardiovascular Surgery, University Hospital, Berne, Switzerland
    Vascular 15:63-9. 2007
    ....
  22. ncbi Protamine after heparin produces hypotension resulting from decreased sympathetic outflow secondary to increased nitric oxide in the central nervous system
    Yoshikazu Hamada
    Department of Anesthesiology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku, Tokyo, 160 0023 Japan
    Anesth Analg 100:33-7. 2005
    ....
  23. ncbi Impairment of parasympathetic baroreflex responses in migraine patients
    E O Sanya
    Autonomic Laboratory, Department of Neurology, University of Erlangen Nuremberg, Germany
    Acta Neurol Scand 111:102-7. 2005
    ..The aim of this study was to assess baroreflex regulation of the heart rate and blood vessels in migraine patients in comparison with healthy controls...
  24. ncbi Dynamic interactions between arterial pressure and sympathetic nerve activity: role of arterial baroreceptors
    Claude Julien
    Départmwnt de Physiologie et Pharmacie Clinique, Faculte de Pharmacie, Université Claude Bernad Lyon, Lyon, France
    Am J Physiol Regul Integr Comp Physiol 285:R834-41. 2003
    ..The weak coupling between slow fluctuations of RSNA and MAP in sham-operated and SAD rats points to the interference of noise sources unrelated to RSNA affecting MAP and of noise sources unrelated to MAP affecting RSNA...
  25. ncbi Central hypercapnic chemoreflex modulation of renal sympathetic nerve activity in experimental heart failure
    A V Kristen
    Abteilung Innere Medizin III, Kardiologie, Angiologie, Pulmologie, Universitat Heidelberg, Germany
    Basic Res Cardiol 97:177-86. 2002
    ....
  26. ncbi High-cut characteristics of the baroreflex neural arc preserve baroreflex gain against pulsatile pressure
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 282:H1149-56. 2002
    ..8 Hz. A numerical simulation indicated that the high-cut characteristics above 0.8 Hz were effective to attenuate the pulsatile signal and preserve the open-loop gain when the baroreflex dynamic range was finite...
  27. ncbi Brain stem control of arterial pressure in chronic arterial baroreceptor-denervated rats
    Ann M Schreihofer
    Dept of Physiology, Medical College of Georgia, 1120 15th St, Augusta, GA 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1746-55. 2005
    ..Baroreceptor-independent regulation of the ventrolateral medulla may underlie central mechanisms contributing to the long-term control of AP...
  28. ncbi Direct injection of substance P-antisense oligonucleotide into the feline NTS modifies the cardiovascular responses to ergoreceptor but not baroreceptor afferent input
    Carole A Williams
    Department of Physiology, College of Medicine, East Tennessee State University, P O Box 70576, Johnson City, TN 37614, USA
    Brain Res 963:26-42. 2003
    ..We suggest that the SP released during isometric contractions excites an inhibitory pathway modulating baroreceptor input, thus contributing to the increase in mean blood pressure...
  29. ncbi Frequency-dependent baroreflex control of blood pressure and heart rate during physical exercise
    Giammario Spadacini
    Dipartimento di Medicina Interna IRCCS S Matteo and University of Pavia, Italy
    Int J Cardiol 107:171-9. 2006
    ..We hypothesised that this uncertainty arose from the differing responses of the vagus (fast) and sympathetic (slow) arms of the autonomic effectors, and to differing sympatho-vagal balance at different exercise intensities...
  30. ncbi Dysfunctional baroreflex regulation of sympathetic nerve activity in patients with vasovagal syncope
    Markus Bechir
    Cardiovascular Center, Cardiology, University Hospital, Ramistrasse 100, 8091 Zurich, Switzerland
    Circulation 107:1620-5. 2003
    ..Hence, the aim of the present study was to investigate MSA, baroreceptor sensitivity, heart rate, and blood pressure under resting conditions and during orthostatic stress in patients with a history of vasovagal syncope...
  31. ncbi AT(1)-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation
    Q H Chen
    Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1844-53. 2001
    ..Results suggest that elevated RSNA after central sodium/osmotic activation is mediated, at least in part, by a synaptic mechanism involving AT(1)-receptor activation within the PVN...
  32. ncbi Arterial baroreceptors mediate the inhibitory effect of acute increases in arterial blood pressure on thirst
    Sean D Stocker
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1718-29. 2002
    ..Thus it appears that arterial baroreceptor afferents mediate the inhibitory effect of an acute increase in AP on thirst stimulated by ANG II or hyperosmolality...
  33. ncbi Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome
    Istvan Bonyhay
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 110:3193-8. 2004
    ..Little is known about sympathetic nerve outflow and its role in hemodynamic control in this disorder...
  34. ncbi Vestibulosympathetic reflex mediates the pressor response to hypergravity in conscious rats: contribution of the diencephalon
    Tomoko Matsuda
    Department of Physiology, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Brain Res 1028:140-7. 2004
    ..These results indicate that output from the vestibular system project to the diencephalon, and activation of diencephalic nuclei is indispensable to the pressor response via the sympathetic nerve system...
  35. ncbi [Representation of the pulse wave of blood pressure by the series of impulses of the pulse-rhythmic neurons in the nucleus tractus solitarii]
    Vytautas Miliukas
    Kauno medicinos universiteto Biomedicininiu tyrimu institutas, Kaunas
    Medicina (Kaunas) 38:553-8. 2002
    ..The similarity of the histograms to the pulse wave shows that the pulse-rhythmic neurons integrate mostly the afferent input received from the arterial baroreceptors...
  36. ncbi Effects of lower body negative pressure on cardiac and vascular responses to carotid baroreflex stimulation
    C M Brown
    Autonomic Laboratory, Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Physiol Res 52:637-45. 2003
    ..Enhanced blood pressure responses to neck suction during higher levels of LBNP are not necessarily the result of a reflex interaction but may serve to protect the circulation from fluctuations in blood pressure while standing...
  37. ncbi Steady-state and dynamic responses of renal sympathetic nerve activity to air-jet stress in sinoaortic denervated rats
    Christian Barrès
    Faculte de Pharmacie, 8, avenue Rockefeller, 69373 Lyon Cedex 08, France
    Hypertension 43:629-35. 2004
    ....
  38. ncbi Alpha-2 adrenergic transmission and human baroreflex regulation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1035-41. 2004
    ..alpha-2 Adrenoceptor stimulation greatly augments baroreflex-mediated bradycardia, most likely by parasympathetic activation...
  39. ncbi Influence of vestibulo-sympathetic reflex on muscle sympathetic outflow during head-down tilt
    J Kawanokuchi
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    Environ Med 45:66-8. 2001
    ..1 G. It is estimated that the vestibulo-sympathetic reflex may suppress sympathetic outflow to muscles in humans...
  40. ncbi Effects of head-up tilting on baroreceptor control in subjects with different tolerances to orthostatic stress
    V L Cooper
    Institute for Cardiovascular Research, University of Leeds, Leeds LS2 9JT, U K
    Clin Sci (Lond) 103:221-6. 2002
    ....
  41. ncbi Haemorrhage-evoked compensation and decompensation are mediated by distinct caudal midline medullary regions in the urethane-anaesthetised rat
    D J Heslop
    Department of Anatomy and Histology, The University of Sydney, Sydney, NSW 2006, Australia
    Neuroscience 113:555-67. 2002
    ....
  42. ncbi Baroreflex control of muscle sympathetic nerve activity after carotid body tumor resection
    Henri J L M Timmers
    Department of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Hypertension 42:143-9. 2003
    ..During the Valsalva maneuver, loss of carotid baroreflex control of heart rate is less well compensated for by the extra carotid baroreceptors than the control of muscle sympathetic nerve activity...
  43. ncbi Reduced baroreceptor reflex sensitivity and increased blood pressure variability at 2400 m simulated cabin altitude
    Knut Sevre
    Department of Cardiology, Ulleval University Hospital, Oslo, Norway
    Aviat Space Environ Med 73:632-4. 2002
    ..5 +/- 3.1 vs. 13.2 +/- 2.0 ms x mm Hg(-1) and 5.4 +/- 1.3 vs. 8.2 +/- 1.1 mm Hg, respectively; p < 0.05). We conclude that autonomic cardiovascular control was disturbed during acute exposure to an air pressure corresponding to 2400 m...
  44. ncbi Reflex control of arterial pressure and heart rate in short-term streptozotocin diabetic rats
    P Dall'Ago
    Departamento de Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 35:843-9. 2002
    ....
  45. ncbi Acute sympathoexcitatory action of angiotensin II in conscious baroreceptor-denervated rats
    Ling Xu
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Physiol Regul Integr Comp Physiol 283:R451-9. 2002
    ..Furthermore, these studies highlight the importance of fully characterizing sinoaortic-denervated rats used in experiments examining the role of baroreceptor reflexes...
  46. ncbi Baroreceptor reflex function
    Harald M Stauss
    Johannes Müller Institut für Physiologie, Humboldt Universität zu Berlin Charité, 10117 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 283:R284-6. 2002
  47. ncbi Verapamil protective effect on natural and artificial magnetic field cardiovascular impact
    Juraj Gmitrov
    Department of Physiological Hygiene, The National Institute of Public Health, Tokyo, Japan
    Bioelectromagnetics 23:531-41. 2002
    ..SMF and GMF probably affect baroreceptor sensory transduction, modulating baroreceptor membranes' Ca(2+) channel permeability...
  48. ncbi Nitric oxide modulation of glutamatergic, baroreflex, and cardiopulmonary transmission in the nucleus of the solitary tract
    Ana Carolina Rodrigues Dias
    Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Brazil
    Am J Physiol Heart Circ Physiol 288:H256-62. 2005
    ..Our results indicate that inhibition of NOS within the NTS attenuates baro- and cardiopulmonary reflexes, suggesting that NO plays a physiologically significant neuromodulatory role in cardiovascular regulation...
  49. ncbi Estimation of the total peripheral resistance baroreflex impulse response from spontaneous hemodynamic variability
    Xiaoxiao Chen
    Department of Electrical and Computer Engineering, Michigan State University, 2120 Engineering Bldg, East Lansing, MI 48824, USA
    Am J Physiol Heart Circ Physiol 294:H293-301. 2008
    ..7 +/- 0.44 to -1.8 +/- 0.2 (P < 0.05)] following the chronic intervention. Moreover, the technique yielded estimates whose values were consistent with those reported with more invasive and/or experimentally difficult methods...
  50. ncbi Systemic cholecystokinin differentially affects baro-activated GABAergic neurons in rat caudal ventrolateral medulla
    Susan C Mobley
    Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
    J Neurophysiol 96:2760-8. 2006
    ..The differential responses of baro-activated GABAergic CVLM neurons to CCK may contribute to the diverse responses of presympathetic RVLM neurons and sympathetic outflows observed with systemic CCK...
  51. pmc Differential effects of cardiac sympathetic afferent stimulation on neurons in the nucleus tractus solitarius
    Wei Zhong Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Neurosci Lett 409:146-50. 2006
    ....
  52. pmc Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate reflex
    J T Potts
    Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, University of Missouri, 134 Research Park Drive, Columbia, MO 65211, USA
    Neuroscience 145:1168-81. 2007
    ..These findings indicate that immunolesioning of NK1-R expressing NTS neurons selectively abolishes the depressive effect of somatosensory input on arterial baroreceptor-heart rate reflex function...
  53. ncbi Effects of high NaCl diet on arterial pressure in Sprague-Dawley rats with hepatic and sinoaortic denervation
    Shuang Gao
    Department of Physiology, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Jpn J Physiol 55:229-34. 2005
    ..e., in SAD+HD rats, mean arterial pressure increased by 13 +/- 1 mmHg. In conclusion, sinoaortic baroreceptor, but not hepatic Na(+) receptor, has a significant role in the long-term regulation of arterial pressure on a high NaCl diet...
  54. pmc Intrathecal cGMP elicits pressor responses and maintains mean blood pressure during haemorrhage in anaesthetized rats
    V Malik
    Cardiology Research, Royal Perth Hospital Unit, School of Medicine and Pharmacology, The University of Western Australia, GPO Box X2213, Perth 6487 Australia
    J Physiol 581:543-52. 2007
    ..The results indicate that cGMP increases blood pressure, and thus suggest that cGMP increases SNA. This supports the hypothesis that the sympathoexcitatory effects of spinal delivery of NO are mediated by a cGMP-dependent mechanism...
  55. ncbi [Baroreflexes and congestive heart failure]
    M C Aumont
    Service de cardiologie A, , Paris
    Arch Mal Coeur Vaiss 88:555-8. 1995
    ..Aldosterone is one of the factors which could activate the Na-K ATPase, as this hormone directly increases pump activity and favorizes the synthesis of new pumps in the vascular smooth muscle cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  56. ncbi Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity
    Shun Guang Wei
    Research Service, Veterans Affairs Medical Center and Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Heart Circ Physiol 282:H890-5. 2002
    ..g., heart failure) in which baroreflex mechanisms are impaired and RAS activity is augmented...
  57. ncbi Muscle mechanoreflex augments arterial baroreflex-mediated dynamic sympathetic response to carotid sinus pressure
    Kenta Yamamoto
    Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho, Tokyo 162 0041, Japan
    Am J Physiol Heart Circ Physiol 295:H1081-H1089. 2008
    ..3.1 +/- 1.5 au; P < 0.05, control vs. stretch) in the SNA step response. A simulation experiment using the results indicated that the muscle mechanoreflex would accelerate the closed-loop AP regulation via the arterial baroreflex...
  58. ncbi Quantification of cardiac baroreflex function at rest and during autonomic stimulation
    Stefan Duschek
    Department Psychologie, Ludwig Maximilians Universitat Munchen, Leopoldstr 13, 80802 Munich, Germany
    J Physiol Sci 57:259-68. 2007
    ..The sensitivity index must be considered the most relevant to quantify baroreflex function among the three parameters...
  59. ncbi Reflex control of sympathetic outflow and depressed baroreflex sensitivity following myocardial infarction
    Christine M Jones
    Department of Internal Medicine Cardiology, Medical College of Virginia Campus of Virginia Commonwealth University, United States
    Auton Neurosci 141:46-53. 2008
    ..These results provide additional support for the hypothesis that depressed reflex control of heart rate following myocardial infarction is related to augmented afferent input from the left ventricle...
  60. ncbi Analysis of heart period and arterial pressure variability in childhood hypertension: key role of baroreflex impairment
    Simonetta Genovesi
    Clinica Nefrologica, S Gerardo Hospital, University of Milano Bicocca, Milan, Italy
    Hypertension 51:1289-94. 2008
    ..A similar baroreflex impairment is also observed in the prehypertensive state. Baroreflex assessment could furnish additional information in the clinical assessment of pediatric hypertension...
  61. ncbi Baroreflex mechanisms regulating mean level of SNA differ from those regulating the timing and entrainment of the sympathetic discharges in rabbits
    Simon C Malpas
    Circulatory Control Laboratory, Department of Physiology, University of Auckland Medical School, Private Bag 92019, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 291:R400-9. 2006
    ..This observation has important implications for understanding the origin and regulation of SNA...
  62. ncbi Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats
    Jin Wang
    Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
    Acta Pharmacol Sin 27:1013-7. 2006
    ..The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure (BP) and blood pressure variability (BPV) in conscious sinoaortic-denervated (SAD) rats...
  63. ncbi Exercise training improves aortic depressor nerve sensitivity in rats with ischemia-induced heart failure
    Eduardo Rondon
    Heart Institute Instituto do Coração, University of Sao Paulo, Brazil
    Am J Physiol Heart Circ Physiol 291:H2801-6. 2006
    ..05). In conclusion, exercise training improves AODN sensitivity in HF rats...
  64. ncbi The hypo-osmolality of pregnancy does not alter baroreceptor responses to acute changes in osmolality
    Tina Hines
    University of Missouri, Kansas City School of Nursing, Kansas City, MO 64108, USA
    Biol Res Nurs 7:214-21. 2006
    ..Their findings suggest that in vitro data from male rats indicating a correlation between pOsm and baroreceptor discharge are not applicable in anesthetized intact female animals...
  65. ncbi Differential baroreceptor modulation mediated by the ventrolateral medulla
    Cássia de Toledo Bergamaschi
    Departamento de Fisiologia, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862, CEP 04023 060, Sao Paulo, SP, Brazil
    Auton Neurosci 126:156-62. 2006
    ..Glutamatergic activation of CPA neurons can cause large increases in the rSNA and BP with a weaker baroreceptor modulation when compared to responses mediated by the RVLM neurons...
  66. ncbi Dissociation of blood pressure and sympathetic activation of renin release in sinoaortic-denervated rats
    Marta H Krieger
    Department of Physiology and Biophysics, Institute of Biology, State University of Campinas, Campinas, SP, Brazil
    Clin Exp Pharmacol Physiol 33:471-6. 2006
    ..86 +/- 0.77 ng AngI/mL per h; n = 5; P < 0.05). Renin mRNA levels in the kidneys were unchanged in all groups. 6. These results show that an elevation in BP appears to offset increased renal sympathetic discharge with no change in PRA...
  67. ncbi Dynamic analysis of renal nerve activity responses to baroreceptor denervation in hypertensive rats
    G F DiBona
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Hypertension 37:1153-63. 2001
    ....
  68. pmc Two sites for modulation of human sympathetic activity by arterial baroreceptors?
    P Kienbaum
    Institute of Clinical Neuroscience, Unit of Clinical Neurophysiology, Sahlgren Hospital, University of Goteborg, Sweden
    J Physiol 531:861-9. 2001
    ..We suggest that the modulation occurs at two sites, one which determines whether or not a burst will occur, and another at which the strength of the discharge is determined...
  69. ncbi Both central command and exercise pressor reflex reset carotid sinus baroreflex
    S A McIlveen
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, California 95616, USA
    Am J Physiol Heart Circ Physiol 280:H1454-63. 2001
    ..Our findings show that central command arising from the MLR as well as the exercise pressor reflex are capable of resetting the carotid baroreflex...
  70. ncbi Evidence for cardiovascular autonomic dysfunction in neonates with coarctation of the aorta
    Jaimie W Polson
    Department of Clinical Sciences at South Bristol, School of Medical Sciences, Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Circulation 113:2844-50. 2006
    ..We hypothesized that early pathological adjustment of autonomic cardiovascular function may already be established in the neonate with coarctation...
  71. ncbi Baroreceptor reflex sensitivity estimated by the sequence technique is reliable in rats
    Harald M Stauss
    Am J Physiol Heart Circ Physiol 291:H482-3. 2006
  72. pmc Characteristics of ongoing and reflex discharge of single splenic and renal sympathetic postganglionic fibres in cats
    R L Meckler
    Department of Physiology, Michigan State University, East Lansing 48824 1101
    J Physiol 396:139-53. 1988
    ..4. Firing of splenic fibres was less inhibited than that of renal fibres by stimulation of pressoreceptors with phenylephrine-induced increases in blood pressure...
  73. ncbi Modeling arterial hypotension during hemodialysis
    M Ursino
    Department of Electronics, Computer Science and Systems, University of Bologna, Italy
    Artif Organs 21:873-90. 1997
    ..The control mechanisms are triggered by information coming from both arterial and cardiopulmonary pressoreceptors, and they work on systemic arterial resistance, heart rate, and systemic venous unstressed volume...
  74. pmc Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava
    Chung S Lim
    Imperial Vascular Unit and Cytokine Biology of Vessels Group, Department of Surgery and Cancer, and the Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Vasc Surg 53:764-73. 2011
    ....
  75. ncbi Functionality of the baroreceptor nerves in heart rate regulation
    J T Ottesen
    Dept of Sciences, System and Models, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark
    Comput Methods Programs Biomed 101:208-19. 2011
    ..In this paper, we analyze the nonlinear afferent model and show that the coupled model is able to predict heart rate regulation using blood pressure data as an input...
  76. ncbi Selective impairment of excitatory pressor responses after prolonged simulated microgravity in humans
    M Pagani
    Dipartimento Medicina Interna, Centro Ricerche Cardiovascolari, CNR, Universita di Milano, Ospedale L Sacco, Italy
    Auton Neurosci 91:85-95. 2001
    ..Simulated microgravity-induced reduction of pressor responses, in spite of largely maintained autonomic activation, favours the hypothesis of a peripheral impairment of cardiovascular homeostasis. rights reserved...
  77. ncbi Neuronal expression of nuclear transcription factor MafG in the rat medulla oblongata after baroreceptor stimulation
    Iku Kumaki
    Department of Laboratory Sciences, Gunma University School of Health Sciences, 3 39 15 Showa Machi, Maebashi shi 371 8514, Japan
    Life Sci 78:1760-6. 2006
    ..Our results suggest that MafG cooperates with FosB to play critical roles as an immediate early gene in the signal transduction of cardiovascular regulation mediated by baroreceptive signals in the medulla oblongata...
  78. ncbi Relationships between baroreceptor cardiac reflex sensitivity and cognitive performance: modulations by gender and blood pressure
    Gustavo A Reyes Del Paso
    Departamento de Psicologia, Universidad de Jaen, 23071 Jaen, Spain
    Psychophysiology 49:138-44. 2012
    ....
  79. ncbi Baroreceptor sensitivity and diabetes mellitus
    Olumide Olatubosun Rowaiye
    Department of Physiology, Wroclaw Medical University, Wroclaw, Poland
    Cardiol J 20:453-63. 2013
    ..Finally, we demonstrate evidence on interventions (e.g. pioglitazone, alpha-lipoic acid, leptin, fluvastatin, physicaltraining etc.) which could improve BRS and ameliorate cardiovascular autonomic dysfunction in diabetic patients. ..
  80. pmc Vasopressin inhibits glutamate release via two distinct modes in the brainstem
    Timothy W Bailey
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 26:6131-42. 2006
    ..Thus, AVP regulates NTS neurons by two distinct novel and state-dependent mechanisms: one, an analog, graded presynaptic inhibition of terminal glutamate release and the other, a binary, extraterminal block of conducted excitation...
  81. ncbi Cardiovascular regulation after destruction of the C1 cell group of the rostral ventrolateral medulla in rats
    Christopher J Madden
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Am J Physiol Heart Circ Physiol 285:H2734-48. 2003
    ..These data suggest that RVLM-C1 cells contribute to the maintenance of baseline arterial pressure and play an integral role in sympathoexcitatory responses...
  82. pmc A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, 95616 0635, USA
    J Neurosci 29:11807-16. 2009
    ..The data suggest a novel mechanism for postsynaptic group II mGluRs to fine-tune baroreceptor signal transmission in the NTS...
  83. pmc Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, Davis, California 95616, USA
    J Neurosci 29:2754-61. 2009
    ..The data suggest that exercise-induced NK1-R internalization results in a reduced intrinsic inhibitory input to the neurons in the baroreflex pathway...
  84. ncbi Plasma hyperosmolality augments peripheral vascular response to baroreceptor unloading during heat stress
    Tomoyuki Ito
    Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Am J Physiol Regul Integr Comp Physiol 289:R432-R440. 2005
    ..These data indicate that there apparently exists an interactive effect of P(osmol) and central hypovolemia on the peripheral vascular response during heat stress, or peripheral vasodilated conditions, but not in normothermia...
  85. ncbi Gender affects calf venous compliance at rest and during baroreceptor unloading in humans
    Kevin D Monahan
    Penn State College of Medicine, Div of Cardiology H047, The Milton S Hershey Medical Center, 500 University Dr, Hershey, PA 17033 2390, USA
    Am J Physiol Heart Circ Physiol 286:H895-901. 2004
    ..e., rest) and high sympathetic outflow (i.e., LBNP). However, they cannot explain gender-associated differences in orthostatic tolerance...
  86. ncbi Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice
    Jens Tank
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Auton Neurosci 136:52-7. 2007
    ..This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice...
  87. ncbi [Neurogenic hypertension]
    Susumu Sasaki
    Akashi Municipal Hospital
    Nippon Rinsho . 2007
  88. ncbi Central pressor actions of aminopeptidase-resistant angiotensin II analogs: challenging the angiotensin III hypothesis
    Ranjita J Kokje
    Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Hypertension 49:1328-35. 2007
    ..These data do not support The Angiotensin III Hypothesis and suggest that conversion of exogenously applied angiotensin II to angiotensin III is not necessary to cause brain-mediated pressor or dipsogenic responses...
  89. ncbi Effects of low-protein diet on the baroreflex and Bezold-Jarisch reflex in conscious rats
    F C Tropia
    Department of Biological Sciences, DECBI, Federal University of Ouro Preto, MG, Brazil
    Nutr Neurosci 4:99-107. 2001
    ....
  90. ncbi Neurogenic and humoral factors maintaining arterial pressure in conscious dogs
    E M Hasser
    Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284 7764
    Am J Physiol 255:R693-8. 1988
    ..The ability of the SNS alone to maintain arterial pressure after acute removal of the other systems is also significantly greater than that of AVP or the RAS...
  91. ncbi [Inhibitory effect of aminoglycoside antibiotics on rabbit carotid baroreceptor activity in vitro]
    D X Liu
    Department of Cardiovascular Physiology, Capital University of Medical Sciences, Beijing 100054
    Sheng Li Xue Bao 53:158-62. 2001
    ....
  92. ncbi Attenuation of the afferent limb of the baroreceptor reflex in streptozotocin-induced diabetic rats
    S Gouty
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Auton Neurosci 89:86-95. 2001
    ..These data suggest that STZ-induced diabetes, for a period of 8 and 16 weeks, results in reduced activity in the afferent baroreceptor input to the NTS, and are consistent with diabetes-induced damage to baroreceptor afferent nerves...
  93. ncbi Mechanism of attenuated thirst in aging: role of central volume receptors
    N S Stachenfeld
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Physiol 272:R148-57. 1997
    ....
  94. ncbi Artificial static and geomagnetic field interrelated impact on cardiovascular regulation
    Juraj Gmitrov
    Department of Physiological Hygiene, National Institute of Public Health, Tokyo, Japan
    Bioelectromagnetics 23:329-38. 2002
    ....
  95. ncbi Mental stress response, arterial stiffness, and baroreflex sensitivity in healthy aging
    Ruth D Lipman
    Laboratory for Cardiovascular Research, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 57:B279-84. 2002
    ..These observations may provide a mechanistic link between the physiology of cardiovascular reactivity to stress and risk of cardiovascular events in middle-aged and older individuals...
  96. ncbi Acupuncture and somatic nerve stimulation: mechanism underlying effects on cardiovascular and renal activities
    T Yao
    Department of Physiology, Shanghai Medical University, China
    Scand J Rehabil Med Suppl 29:7-18. 1993
    ..Preliminary studies show that different neurotransmitters and neuropeptides are involved in the effects of acupuncture...
  97. ncbi Gender difference in baroreflex-mediated bradycardia in young rats: role of cardiac sympathetic and parasympathetic components
    A A Abdel-Rahman
    Department of Pharmacology, East Carolina University, School of Medicine, Greenville, NC 27858, USA
    Can J Physiol Pharmacol 77:358-66. 1999
    ....
  98. ncbi Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients
    Thierry Boulain
    Service de Reanimation Medicale, Hopital de Bicetre, Faculte de Medecine Paris Sud, Paris, France
    Chest 121:1245-52. 2002
    ....
  99. ncbi Similarities in reflex control of laryngeal and cardiac vagal motor neurones
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
    Respir Physiol 119:101-11. 2000
    ..Our observations lend further support to models of cardiorespiratory control which propose close coupling and shared central mechanisms for the regulation of the cardiovascular and respiratory systems...
  100. ncbi Cardiovascular reflexes during rest and exercise modified by gravitational stresses
    F Bonde-Petersen
    Laboratory for Human Physiology, August Krogh Institute, Copenhagen, Denmark
    Acta Astronaut 8:951-8. 1981
    ..Application of exercise and local hydrostatic stresses in combination with gravitational stresses represent an interesting model for further study of the mechanisms behind the distribution of cardiac output to the peripheral organs...
  101. ncbi Right prefrontal activation produced by arterial baroreceptor stimulation: a PET study
    J Weisz
    Eotvos Lorand University, Hungarian Academy of Sciences, Szondi u 83 85, Budapest H 1068, Hungary
    Neuroreport 12:3233-8. 2001
    ..We conclude that in at least some stages of baroreceptor information processing the right hemisphere plays a greater role than the left hemisphere...

Research Grants58

  1. Neuromechanical basis of baroreceptor function
    John H Schild; Fiscal Year: 2010
    ..The data quantifying the properties of these pressoreceptors and the reflexogenic consequences of BR function and dysfunction are extensive...
  2. Arterial baroreceptor unloading causes hypertension
    TERRY THRASHER; Fiscal Year: 2005
    ..These studies will provide a new framework for understanding the development and maintenance of hypertension. ..
  3. BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONS
    SUSAN BARMAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  4. CENTRAL NEURAL CONTROL OF CARDIOVASCULAR FUNCTION
    GERARD GEBBER; Fiscal Year: 2002
    ..The above listed hypotheses will be tested by examining the interrelations of these signals using computational methods including spike-triggered averaging, phase plane, ordinary and partial coherence and bicoherence analyses. ..
  5. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ....
  6. Confer. Neural Mechanisms in Cardiovascular Regulation
    MARK CHAPLEAU; Fiscal Year: 2002
    ..Time will be allotted for informal discussions and social interaction. Scientists from the United States and other countries, young investigations and women are well-represented in the program. ..
  7. Detecting Endothelial Dysfunction in Renal Failure
    Julian Stewart; Fiscal Year: 2007
    ..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
  8. Fetal Programming of Coronary Artery Disease
    JEFFREY SEGAR; Fiscal Year: 2005
    ..Only when the causes and mechanisms of hypertension and cardiovascular disease are understood in the context of a developmental process will it be possible to develop strategies for primary prevention. ..
  9. SYMPATHETIC EXCITATORY RESPONSE AT BIRTH
    JEFFREY SEGAR; Fiscal Year: 2001
    ....
  10. Fetal Cardiac Hypertrophy: Vascular/Metabolic Adaptation
    JEFFREY SEGAR; Fiscal Year: 2004
    ..The end result is hoped to be that the infant with a more 'normal' heart and circulatory physiology will have improved survival with less morbidity. ..
  11. Role of Parabrachial 5-HT in Thirst and Salt Appetite
    Alan Johnson; Fiscal Year: 2005
    ..g., hypertension; congestive heart failure; renal disease). ..
  12. Behavioral state development in infants
    Mark Blumberg; Fiscal Year: 2009
    ..abstract_text> ..
  13. Convergent central pathways for sympatho-inhibition
    CARON DEAN BERNHOFT; Fiscal Year: 2005
    ..These novel data will be of potential significance to an array of pathologies and behaviors including emotional behaviors, analgesia, shock, sexual function and fainting. ..
  14. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  15. Humoral Interactions in long-term blood pressure control
    VIRGINIA BROOKS; Fiscal Year: 2005
    ..abstract_text> ..
  16. Continuous Cardiac Output & Filling Pressure Monitoring
    Ramakrishna Mukkamala; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. NEUROPATHOLOGY AND PATHOGENESIS OF HUNTINGTON' DISEASE
    Anton Reiner; Fiscal Year: 2004
    ....
  18. Presynaptic Mechanisms of Neurotransmission in NTS
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..The different sub classes of afferent nerve terminal will be also be compared in terms of their control of glutamate release and modulation by peptides. ..
  19. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2001
    ....
  20. Acupuncture in Cardiovascular Disease
    Holly Middlekauff; Fiscal Year: 2002
    ....
  21. CARDIOVASCULAR CONCOMITANTS OF ULTRASONIC VOCALIZATIONS
    Mark Blumberg; Fiscal Year: 2002
    ..Through these approaches, an integrated view of the varied mechanisms by which infant and adult mammals regulate cardiovascular function during physiological and behavioral challenges will emerge. ..
  22. NEUROPEPTIDES AND CARDIOVASCULAR REGULATION
    VIRGINIA BROOKS; Fiscal Year: 2002
    ....
  23. BASAL GANGLIA--ANATOMICAL AND FUNCTIONAL ORGANIZATION
    Anton Reiner; Fiscal Year: 2003
    ..g. Huntington's and Parkinson's disease), which may in turn make it possible to devise more effective preventive and therapeutic measures for such disorders. ..
  24. AUTONOMIC REGULATION IN HEART FAILURE
    Lawrence Sinoway; Fiscal Year: 2003
    ..This K24 award will reduce the PI's administrative and clinical commitment and thereby allow him to continue his human investigative work and to spend more time training talented patient-oriented investigators. ..
  25. Sympathetic Nerve Activity and the Skeletal Myopathy of Heart Failure
    Holly R Middlekauff; Fiscal Year: 2010
    ..2.1 Is the sympatholysis with clonidine associated with a reversal of the skeletal myopathy in HF? 2.2 What is the effect of the improved skeletal myopathy on muscle mechanoreceptor sensitivity in HF? ..
  26. Autonomic Nervous System in Chronic Fatigue Syndrome
    Italo Biaggioni; Fiscal Year: 2009
    ....
  27. Differential sympathetic reflex control in excerise
    Marc Kaufman; Fiscal Year: 2009
    ..The proposed experiments will provide new information about the role played by thin fiber muscle mechanoreceptors and metaboreceptors in controlling the sympathetic outflow during exercise. ..
  28. Noninvasive Quantification of the Resistance Baroeflex
    Ramakrishna Mukkamala; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..
  30. Statistical Methods for the Genomic Analysis of Gene Expression Data
    Christina Kendziorski; Fiscal Year: 2010
    ..Successful completion of the proposed research will result in substantially improved statistical methods for these 2 important categories of genomic studies. ..
  31. Concept: Stress, Cytokines and Heart Disease in Police
    WARREN FRANKE; Fiscal Year: 2007
    ..The proposed work is significant because it is expected to increase our understanding of the mechanisms underlying the pathogenesis of cardiovascular disease in this high stress occupation. [unreadable] [unreadable] [unreadable]..
  32. Particulate Matter Exposure: Cardiovascular Mechanisms
    Chao Yin Chen; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. Autonomic Neurovascular Regulation
    Lawrence Sinoway; Fiscal Year: 2008
    ..Core Laboratory B will be a physiology core. All projects will use this core. ..
  34. Sympathetic overactivity & hypertension in ERSD: A role for ADMA
    PAUL FADEL; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Estrogen Influences on Fetal Adrenocorticotropin
    Charles Wood; Fiscal Year: 2006
    ..abstract_text> ..
  36. Arterial Baroreflex Control of Blood Pressure (Exercise)
    Peter Raven; Fiscal Year: 2006
    ..These findings will have implications for the care of patients suffering from non-insulin dependent diabetes mellitus (NIDDM), hypertension and cardiac failure. ..
  37. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ....
  38. Pooling Designs for Microarray Studies
    Christina Kendziorski; Fiscal Year: 2004
    ..abstract_text> ..
  39. ESTROGEN EFFECTS ON CARDIOVASCULAR RESPONSE TO EXERCISE
    Marc Kaufman; Fiscal Year: 2005
    ....
  40. Sympathetic-Immune Interface: Central Sites & Function
    MICHAEL KENNEY; Fiscal Year: 2005
    ..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
  41. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2005
    ..The design of these studies will increase our understanding of how the vestibular system contributes to orthostatic blood pressure regulation in humans. ..
  42. ADRENERGIC CONTROL OF CENTRAL SYMPATHETIC ACTIVITY
    Antonio Granata; Fiscal Year: 2001
    ....
  43. REM SLEEP DEPRIVATION, HYPOXIA, AND HIPPOCAMPAL FUNCTION
    David Gozal; Fiscal Year: 2003
    ..abstract_text> ..
  44. Postnatal Brain Susceptibility to Intermittent Hypoxia
    David Gozal; Fiscal Year: 2006
    ....
  45. PAIN REGULATORY SYSTEM DYSFUNCTION IN CHRONIC PAIN
    Stephen Bruehl; Fiscal Year: 2002
    ..Greater pain duration is expected to be associated with smaller changes in the BP/pain relationship in response to opioid blockade. ..
  46. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  47. Transmission Across the First Synapse of the Baroreflex
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..These Aims will provide new and direct information about NTS that leads to a better understanding of the normal basis of the neural control of the circulation as pathophysiology. ..
  48. Muscle Mechanosensitivity in Heart Failure
    Holly Middlekauff; Fiscal Year: 2004
    ..After a 4 week conditioning program, which reverses the myopathy of HF, the above testing repeated to determine if the muscle mechanoreceptor sensitization is reversible. ..
  49. Estrogen and Sympathetically Mediated Vasoconstriction
    PAUL FADEL; Fiscal Year: 2004
    ..abstract_text> ..
  50. Neuronal Mechanisms of Opioid Action
    Hong Zhu; Fiscal Year: 2004
    ..These experiments will improve our understanding of neuronal mechanisms of opioid action, which is crucial for understanding and perhaps treating of opioid addiction. ..
  51. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
  52. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..Data from these patient- oriented studies have implications related to understanding the contribution of endothelial function in a variety of common diseases. ..
  53. Pain Regulatory Dysfunction in Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  54. Patient-Oriented Models for Urinary Function in Women
    Linda Brubaker; Fiscal Year: 2008
    ..unreadable] b. To model urinary storage in health and disease [unreadable] c. To model urinary emptying in health and diseas [unreadable] [unreadable]..
  55. Neurobehavioral Control of Body Fluid Balance in Mouse
    Alan Johnson; Fiscal Year: 2009
    ..heat) challenges. These studies will be especially important for understanding mechanisms underlying pathological conditions such as hypertension and congestive heart failure where excess thirst and sodium intake have been documented. ..
  56. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2006
    ..By examining different anesthetics, we may also better understand whether potentially new anesthetics might be designed to spare these cardioregulatory sites. [unreadable] [unreadable]..
  57. BIOBEHAVIORAL FACTORS IN ATHEROSCLEROTIC PROGRESSION
    Thomas Kamarck; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  58. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2009
    ....